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Anti-aging research > Phenylalanine
DL-Phenylalanine
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Specific Recommendations:
News & Research:
- Drug May
Obviate Dietary Restriction for Hyperphenylalaninemia - Medscape,
12/26/02
-
I have had lower back pain since 1973. Do you have any suggestions? -
Life Extension Magazine, 3/02
-
Exercise Levels Of Phenylethylamine May Damp Depression - Doctor's
Guide, 9/27/01 -
"Administration of phenylethylamine or its precursor
L-phenylalanine, in conjunction with selegiline, a selective monoamine
oxidase B inhibitor, has been reported to alleviate depression and to
produce improvements in mood. The effects are sustained and also apparent in
some patients who are insensitive to conventional treatment"
- Amino
Acids anyone? - DrBob.org -
"L-phenylalanine can also be converted (through a
separate pathway) to phenylethylamine, a substance that occurs naturally in
the brain and appears to elevate mood." See my
phenylethylamine page.
- When It Comes to
Love, the Nose Knows - WebMD, 2/14/01-
"I believe that PEA (phenylethylamine) may be the
hormone of libido"
-
Catecholamines Kick Out the Demons of Depression - Life Enhancement
Magazine, 7/99
-
Natural Remedies for Depression - Nutrition Science News, 2/99 -
"D-phenylalanine, which does not normally occur in
the body or in food, is metabolized to phenylethylamine (PEA), an
amphetaminelike compound that occurs normally in the human brain and has
been shown to have mood-elevating effects. Decreased urinary levels of PEA
(suggesting a deficiency) have been found in some depressed patients.
Although PEA can be synthesized from L-phenylalanine, a large proportion of
this amino acid is preferentially converted to L-tyrosine. D-phenylalanine
is therefore the preferred substrate for increasing the synthesis of
PEA--although L-phenylalanine would also have a mild antidepressant effect
because of its conversion to L-tyrosine and its partial conversion to PEA.
Because D-phenylalanine is not widely available, the mixture
D,L-phenylalanine is often used when an antidepressant effect is desired"
Abstracts:
- The
effects of phenylalanine on exercise-induced fat oxidation: a preliminary,
double-blind, placebo-controlled, crossover trial - J Int Soc Sports
Nutr. 2017 Sep 12;14:34 - "Oral intake of
phenylalanine caused a significant increase in the concentrations of plasma
glycerol and glucagon during exercise. The respiratory exchange ratio was
also decreased significantly following ingestion of phenylalanine ... These
results suggested that pre-exercise supplementation of phenylalanine may
stimulate whole body fat oxidation. No serious or study-related adverse
events were observed" - [Nutra
USA] - See phenylalanine at Amazon.com.
-
Reduction of Brain Dopamine Concentration With Dietary Tyrosine Plus
Phenylalanine Depletion - Am J Psychiatry. 2003 Oct;160(10):1887-9 -
"Healthy male subjects were scanned on two occasions:
once after receiving a balanced amino acid drink and once after receiving a
drink mixture from which
tyrosine
and phenylalanine were omitted ... Dietary tyrosine and phenylalanine
depletion increased [11C]raclopride binding in the striatum by a mean of 6%.
The change in [11C]raclopride binding correlated significantly with the fall
in the ratio of tyrosine and phenylalanine to large neutral amino acids"
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