To address the growing use of ad blockers we now use affiliate links to sites like Amazon.com, streaming services, and others. Affiliate links help sites like QualityCounts.com stay open. Affiliate links cost you nothing but help me support my family. We do not allow paid reviews on this site. As an Amazon Associate I earn from qualifying purchases.  Also, you can donate  to ben@qualitycounts.com via Zelle or PayPal.  Click here for the PayPal QR.  Click here for Bitcoin QR code or Bitcoin address: 39muDw6WpQV8j6EdA8eUBvT5iFDiVpVpiE
Home ReliableRXPharmacy Past Newsletters Amazon.com Contact
 Sign-up for newsletter 
 Newsletter Archive
 Newsletter via RSS Feed
 Research on Supplements
 Health Conditions
 Anti-aging Recommendations
 Insulin and Aging
 QualityCounts.com in Time
 Longevity Affiliates:

Home > Anti-aging Research > Antidepressants > SAM-e

SAM-e (S-adenosylmethionine)


Related Topics:

Specific Recommendations:

News & Research:

  • Supplement Plus Probiotic May Improve Depressive Symptoms - Medscape, 8/12/20 - "randomly assigned 90 patients with subthreshold or mild-to-moderate depression to receive either SAMe plus L. plantarum HEAL9 or placebo for 6 weeks and found significant reductions in depression, anxiety, and cognitive symptoms as early as 2 weeks following treatment initiation ... The effect of this novel product is independent from the severity of the symptoms, unlike traditional antidepressants available on the market that have minimal benefits for subthreshold or mild-to-moderate symptoms ... Extensive research has also shed light on the role of microbiota in patients with depressive disorder, suggesting a role for probiotic supplementation. A probiotic called L. plantarum 299v has been found to have a significant effect on stress markers, such as cortisol levels ... At 2 weeks, participants showed significant reductions in the cognitive and anxiety subdomains of the Z-SDS" - See probiotic supplements at Amazon.com and iHerb and SAM-e at Amazon.com and iHerb.
  • Nutrient supplements can give antidepressants a boost - Science Daily, 4/26/16 - "Omega 3 fish oils, S-adenosylmethionine (SAMe), methylfolate (bioactive form of folate) and Vitamin D, were all found to boost the effects of medication ... They reported mixed results for zinc, vitamin C and tryptophan (an amino acid). Folic acid didn't work particularly well, nor did inositol" - Note: For people who want an increase in energy and mood with anti-aging effects to boot, I’d skip the antidepressants and go with a combination of deprenyl, lithium (the over-the-counter supplement form), GH-3 and beta-arginine. On the beta-arginine, it will weird you out if you don’t start slow and take it with food if possible. Build yourself up to 3200 mg per day.  Don’t take more than 800 mg per three or four hour period.  Check with a doctor first on all of that.  Also, see methylfolate at Amazon.com.
  • Adding Nutritional Supplement to Antidepressant Therapy May Boost Response in Refractory Depression - Medscape, 8/18/10 - "significantly more SAMe-treated than placebo-treated patients (36.1% vs 17.6%) experienced a clinical response on the 17-item Hamilton Depression Rating Scale (HAM-D), which was the primary study outcome. Remission rates (ie, HAM-D score of ≤7) were also higher with SAMe than with placebo (25.8% vs 11.7%)"
  • Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary Liver Cancer In Rats - Science Daily, 7/30/09 - "A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats" - [Abstract]
  • Can SAM-e Hurt My Heart? - Dr. Weil, 10/10/08 - "Since SAM-e is ultimately converted in the body to homocysteine, it is theoretically possible that taking it could elevate homocysteine levels. But that doesn't happen. In fact, SAM-e actually appears to lower homocysteine by helping the body metabolize it"
  • SAMe review - ConsumerLab.com, 4/26/07
  • Report: Same - Life Extension Magazine, 4/07
  • Improvement of aggressive behavior and quality of life impairment following S-Adenosyl-Methionine (SAM-e) augmentation in schizophrenia - Eur Neuropsychopharmacol. 2008 Sep 26 - "Eighteen patients with chronic schizophrenia were randomly assigned to receive either SAM-e (800 mg) or placebo for 8 weeks in double-blind fashion. Results indicated some reduction in aggressive behavior and improved quality of life following SAM-e administration. Female patients showed improvement of depressive symptoms"
  • 8 natural pain relievers - MSNBC, 9/14/08 - "Capsaicin: For arthritis, shingles, or neuropathy ... InflaThera or Zyflamend: For arthritis ... Aquamin: For osteoarthritis ... SAM-e (S adenosylmethionine): For osteoarthritis ... Fish oil: For joint pain from arthritis or autoimmune disorders ... Methylsulfonyl-methane (MSM): For osteoarthritis"
  • Patients Seek Natural Alternatives to NSAIDs - Clinical Psychiatry News, 7/05 - "SAMe appeared to be as effective as NSAIDs in reducing pain and improving functionality with fewer adverse effects than NSAIDS"
  • SAMe - A Natural Compound that Offers Safe, Effective Relief from Depression, Osteoarthritis, and Liver Disease - Life Extension Magazine, 1/05 - "SAMe offers arthritis relief without the side effects associated with NSAIDs. Given its safety and tolerability record, SAMe supplementation is recommended for anyone interested in maintaining optimal liver function. Finally, SAMe is a valuable and effective tool for managing depression, offering a safe, effective alternative to prescription medications"
  • SAMe Bioavailability and Lack of Toxicity in Humans - Medscape, 12/16/04
  • Small Study Shows SAMe May Improve Treatment Of Depression - Science Daily, 12/9/04
  • Dietary Supplement Ups Antidepressant Effect - WebMD, 12/2/04 - "Half the patients in the study reported significant improvement in symptoms when they took SAMe along with their prescription antidepressant for six weeks. Forty-three percent reported having no depression symptoms at all six weeks after adding the dietary supplement to their treatment"
  • S-Adenosylmethionine (SAMe) - A Very Important Natural Product - Dr. Murray's Natural Facts, 6/2/04 - "SAMe is perhaps the most effective natural antidepressant (although a strong argument could be made for the extract of St. John's wort standardized to contain 0.3% hypericin)" - See iHerb SAMe products.
  • Supplement SAM-e Helps Beat Depression - WebMD, 5/5/04 - "When SAM-e was added to their usual medication, half of the patients improved and 43% went into remission, Alpert reports. "These are quite strong responses and remission rates for a population that failed traditional therapy.""
  • S-Adenosyl Methionine May Be As Efficacious As Celecoxib in Management of Knee Osteoarthritis, But Onset of Action Is Slower - Doctor's Guide, 5/4/04 - "During the first month of phase 1, celecoxib was significantly more effective in reducing pain than was SAMe (P= .024); however, by the second month of phase 1, patients in both groups had significant pain improvement from baseline (PS</i>] < .01), and no significant difference in pain was observed between groups"
  • A New Era for SAMe - Life Extension Magazine, 6/03
  • Cirque choreographer promotes new twist on joint health - USA Today, 9/9/03
  • S-Adenosyl-L-Methionine Results Similar to Imipramine in Major Depression - Doctor's Guide, 12/30/02 - "A total of 146 patients received 400 milligrams per day of intramuscular SAMe and 147 received 150 mg/d of oral imipramine ... SAMe and imipramine did not differ significantly on any efficacy measure, either main or secondary ... Adverse events were significantly less in patients treated with SAMe compared to those treated with imipramine" - Note:  There seems to be conflicting studies on whether oral SAMe is poorly absorbed.  I've added absorption studies near the bottom of my SAMe page.  Maybe the difference is "Enteric coating" tablets.
  • SAMe Beneficial in Treating Osteoarthritis, Depression, and Liver Disease - New Hope Natural Media, 12/12/02 - "More than 100 human studies have been published in medical journals showing that SAMe is a safe, effective treatment and, in the cases of depression and osteoarthritis, works as well as conventional medications"
  • SAM-e Same As Drugs - Functional Foods & Nutraceuticals, 12/02
  • Supplement [SAM-e] Found Effective As Antidepressant - Intelihealth, 11/6/02 - "The dietary supplement SAMe is about as effective as older, conventional antidepressants in treating depression, a preliminary, government-funded study says. It also finds SAMe to be comparable to non-steroidal anti-inflammatory medications in treating the pain of osteoarthritis. Such drugs include aspirin, ibuprofen and naproxen"
  • Expert Panel Finds SAMe Promising - WebMD, 10/10/02 - "As a treatment for depression, SAMe was shown to be as effective as antidepressants, and more effective than placebo. SAMe also had fewer side effects when compared with standard antidepressants ... As a treatment for osteoarthritis, SAMe had fewer digestive side effects than anti-inflammatory drugs like ibuprofen, yet was effective in relieving pain ... SAMe is a natural substance for the body, it's not a designer drug, and therefore can be carried in, absorbed into pathways," ... The L-dopa medication that patients take for Parkinson's makes them unusually SAMe-deficient "because L-dopa consumes vast quantities of SAMe, like a sponge, it mops up all the SAMe in the body." - See iHerb SAMe products.
  • SAMe aids arthritis without side effects - Life Extension Magazine, 10/02
  • The Wizard is Oz - Life Extension Magazine, 11/01 - "Best-selling author and nutritional guru to the rich and famous, Oz Garcia is singing the praises of the Life Extension Foundation and its products in his newest book, The Healthy High Tech Body, published in September 2001 ... Supplements at the top of Garcia's list of recommendations ... DHA ... NADH ... Alpah Lipoic Acid ... Acetyl-L-Carnitine ... An expanded list of his recommendations includes lycopene, gamma tocopherol, vinpocetine, SAMe, folic acid, carnosine, glutathione, DMAE, Huperzine A, probiotics, MSM, secretagogues, arginine pyroglutamate, IP-6, bioflavonoid formulas and grape skin/seed extracts"
  • Some SAMe Supplements Found Lacking, About Half Had Less of the Active Ingredient Than Labels Implied - WebMD. 5/29/01 - "ConsumerLab.com found that about half the 13 products it tested were accurately labeled as to their SAMe content. Some brands alleged to contain 200 mg actually had about half that, because manufacturers factored in not just the weight of "free" SAMe -- the "therapeutic" portion -- but also an inactive SAMe ingredient"
  • Caution in Treating PD Depression - Nutrition Science News, 5/01 - "SAMe depletes dopamine and can produce PD-like changes in animals, causing cell degeneration in the nigra and striatum areas of the brain"
  • Diet, Supplements, Exercise and Sauna - Life Extension Magazine, 9/99 - "TMG, on the other hand, is very effective at raising the levels of SAMe and lowering homocysteine."
  • SAMe Needs The B's - Nutrition Science News, 7/00 - "users of this wonder pill should be aware that through the natural metabolism of SAMe, the amino acid homocysteine is created--a situation that can lead to artery damage and even heart disease. . . . .others have demonstrated that by simply upping one's intake of the vitamins B6, B12 and folic acid, this potential hazard can be avoided." - Note:  TMG is a precursor to SAM-e and lowers homocysteine instead of raising it.
  • Depression Protocol - Life Extension Foundation
  • Newsweek magazine, 3/22/99
    "...SAM-e appears comparable to state-of-the-art treatments for both conditions [arthritis and depression]. And unlike the leading drug therapies, it lacks significant side effects. Dr. Richard Brown [co-author of "Stop Depression Now"] a Columbia University Psychiatrist describes it as the 'best anti-depressant I've ever prescribed." "...it's cheaper than many prescription remedies. And if it lives up to its promise, it may be more valuable."


Absorption Information:

Note:  There seems to be conflicting studies on whether oral SAMe is poorly absorbed.  Maybe the difference is "Enteric coating" tablets.