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Home > Anti-aging Research > Chromium.


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  • Effects of chromium supplementation on oxidative Stress biomarkers - Int J Vitam Nutr Res 2021 May 20 - "Overall, this meta-analysis demonstrated that chromium supplementation increased GSH without any significant changes in the mean of GPX, MDA, TAS, TBARS, CAT and SOD" - See chromium supplements at Amazon.com.
  • Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review (.pdf) - Nutrients. 2018 Dec 3;10(12) - "There are a few dietary supplements that appear to help preserve LBM during weight loss or to reduce the loss of LBM as compared to diet alone. One such dietary supplement that appears to have this “LBM sparing” effect is chromium picolinate. For the reasons shared in this paper, it seems logical to include CrP as part of any reduced calorie (diet) plan as a means of keeping metabolically active LBM. Weight loss without CrP may be at the cost of LBM, thus, this adjunctive strategy appears worthy of further research and applied practice. A comprehensive approach, integrating evidence-guided macronutrient and calorie intake, resistance exercise, and chromium picolinate may be the most effective approach to preserving or increasing lean body mass while maximizing body fat mass reductions." - [Nutra USA] - See chromium picolinate at Amazon.com.
  • Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein - J Int Soc Sports Nutr. 2017 Feb 8 - "muscle protein synthesis (FSR) ... amylopectin/chromium (ACr) complex ... consumed 6 g whey protein + 2 g of the amylopectin-chromium complex (WPACr) or 6 g whey protein (WP) after an overnight fast ... These data indicate that the addition of ACr to a 6 g dose of whey protein (WPACr) increases the FSR response beyond what is seen with a suboptimal dose of whey protein alone" - [Nutra USA] - See NOW Sports Waxy Maize Powder, 5.5-Pound at Amazon.com and chromium supplements at Amazon.com.
  • Supplementation of Diabetic Rats with Leucine, Zinc, and Chromium: Effects on Function and Histological Structure of Testes - Int J Vitam Nutr Res. 2016 Jul 5:1-11 - "Administration of nutritional supplements to the diabetic rats improved testes morphology and reversed, although not completely, impairment of spermatogenesis. Treatment with nutritional supplements increased testicular length, height, width, and volume. All treatments increased the number of live sperm and the total number of epididymal sperm. Furthermore, nutritional supplements increased diameter of tubules, height of epithelium, and the number of cells in seminiferous tubules. These alleviating effects were more pronounced in animals treated with the leucine-zinc-chromium combination. The present results demonstrate beneficial effects of zinc, leucine, and chromium supplements to improve testes morphology and to restore spermatogenesis in type 2 diabetic rats" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram).
  • Risk of Type 2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements - J Nutr. 2015 Oct 7 - "Compared with nonusers, the odds of having T2D (HbA1c ≥6.5%) were lower in persons who consumed chromium-containing supplements within the previous 30 d than in those who did not (OR: 0.73" - See chromium supplements at Amazon.com.
  • Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study - J Trace Elem Med Biol. 2015 Oct - "A four month controlled, single blind, randomized trial was performed with 71 patients with poorly controlled (hemoglobin A1c [HbA1c]>7%) T2DM divided into 2 groups: Control (n=39, using placebo), and supplemented (n=32, using 600μg/day CrPic) ... CrPic supplementation significantly reduced the fasting glucose concentration (-31.0mg/dL supplemented group; -14.0mg/dL control group; p<0.05, post- vs. pre-treatment, in each group) and postprandial glucose concentration (-37.0mg/dL in the supplemented group; -11.5 mg/dL in the control group; p<0.05). HbA1c values were also significantly reduced in both groups (p<0.001, comparing post- vs. pre-treatment groups). Post-treatment HbA1c values in supplemented patients were significantly lower than those of control patients. HbA1c lowering in the supplemented group (-1.90), and in the control group (-1.00), was also significant, comparing pre- and post-treatment values, for each group (p<0.001 and p<0.05, respectively) ... HDL-c and LDL-c were significantly lowered, comparing pre- and post-treatment period, in the control group" - [Nutra USA]
  • Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial - Ann Nutr Metab. 2015 Jul 31 - "randomized to receive 200 µg chromium picolinate supplements (n = 32) or placebo (n = 32) for 8 weeks ... Chromium supplementation in women with PCOS resulted in significant decreases in serum insulin levels (-3.6 ± 7.4 vs. +3.6 ± 6.2 µIU/ml, p < 0.001), homeostasis model of assessment-insulin resistance (HOMA-IR; -0.8 ± 1.6 vs. +0.9 ± 1.5, p < 0.001), homeostatic model assessment-beta cell function (HOMA-B; -15.5 ± 32.3 vs. +13.6 ± 23.1, p < 0.001), and a significant increase in quantitative insulin sensitivity check index (QUICKI) score (+0.02 ± 0.03 vs. -0.008 ± 0.02, p = 0.001) compared with the placebo. In addition, a trend toward a significant effect of chromium supplementation on decreasing serum triglycerides (-12.4 ± 74.4 vs. +15.2 ± 32.4 mg/dl, p = 0.05), very low-density lipoprotein-cholesterol (-2.5 ± 14.9 vs. +3.0 ± 6.5 mg/dl, p = 0.05), and cholesterol concentrations (-8.6 ± 21.9 vs. +0.7 ± 22.4 mg/dl, p = 0.09) was seen"
  • Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes - J Clin Pharm Ther. 2014 Mar 17 - "Overall, chromium mono- and combined supplementation significantly improved glycaemic control (mean difference for HbA1c -0.55% ... chromium monotherapy significantly reduced triglycerides and increased HDL-C levels. The effects on glucose and triglycerides levels were shown especially with chromium picolinate. Glycaemic control may improve with chromium monosupplementation of more than 200 μg daily. HbA1c and FPG also improved in patients with inadequate glycaemic control at baseline. The risk of adverse events did not differ between chromium and placebo"
  • Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials - Obes Rev. 2013 Mar 18 - "Electronic searches were conducted in Medline, Embase, Amed and The Cochrane Library ... A meta-analysis of 11 studies showed a statistically significant difference in weight loss favouring chromium over placebo (mean difference (MD): -0.50 kg; 95% confidence interval (CI): -0.97, -0.03). There was a high statistical heterogeneity. Adverse events included watery stools, vertigo, headaches and urticaria. The evidence from available RCTs shows that chromium supplementation generates statistically significant reductions in body weight"
  • Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice - Biochem Biophys Res Commun. 2010 May 27 - "Chromium supplementation prevented progression of NAFLD and the beneficial effects were accompanied by reduction of hepatic triglyceride accumulation, elevation of hepatic lipid catabolic enzyme, improvement of glucose and lipid metabolism, suppression of inflammation as well as resolution of oxidative stress, probably through enhancement of insulin signaling. Our findings suggest that chromium could serve as a hepatoprotective agent against NAFLD"
  • Improved cognitive-cerebral function in older adults with chromium supplementation - Nutr Neurosci. 2010 Jun;13(3):116-22 - "In a placebo-controlled, double-blind trial, we randomly assigned 26 older adults to receive either chromium picolinate (CrPic) or placebo for 12 weeks ... Although learning rate and retention were not enhanced by CrPic supplementation, we observed reduced semantic interference on learning, recall, and recognition memory tasks. In addition, fMRI indicated comparatively increased activation for the CrPic subjects in right thalamic, right temporal, right posterior parietal, and bifrontal regions. These findings suggest that supplementation with CrPic can enhance cognitive inhibitory control and cerebral function in older adults at risk for neurodegeneration"
  • Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation - Metabolism. 2007 Dec;56(12):1652-5 - "Sixty-three percent of the subjects with type 2 diabetes mellitus responded to the Cr treatment as compared with 30% with placebo ... Subject phenotype appears to be very important when assessing the clinical response to Cr because baseline insulin sensitivity was found to account for nearly 40% of the variance in the clinical response to Cr"
  • Effect of Chromium Supplementation on Glucose Metabolism and Lipids: A Systematic Review of Randomized Controlled Trials - Diabetes Care. 2007 May 22 - "There was no benefit in individuals without diabetes ... Chromium supplementation significantly improved glycemia among patients with diabetes"
  • The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Trial - Diabetes Technol Ther. 2006 Dec;8(6):636-643 - "randomized to receive 600 microg of chromium as chromium picolinate and biotin (2 mg/day) ... supplementation with a combination of chromium picolinate and biotin in poorly controlled patients with diabetes receiving antidiabetic therapy improved glucose management and several lipid measurements. Chromium picolinate/ biotin supplementation may represent an effective adjunctive nutritional therapy to people with poorly controlled diabetes with the potential for improving lipid metabolism"
  • Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes - Diabetes Care. 2006 Aug;29(8):1826-32 - "1,000 mug Cr as CrPic ... CrPic supplementation in subjects with type 2 diabetes who are taking sulfonylurea agents significantly improves insulin sensitivity and glucose control. Further, CrPic supplementation significantly attenuated body weight gain and visceral fat accumulation compared with the placebo group" - See chromium supplements at Amazon.com.
  • The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial - Metabolism. 2006 Jul;55(7):923-7 - "one group to receive chromium-containing milk powder (chromium 200 mug/20 g milk powder) and the other to receive placebo twice a day for 16 weeks ... The chromium group demonstrated a lower FPG and fasting insulin (-38.1 +/- 9.2 vs 63 +/- 8. 5 mg/dL and -1.7 +/- 0.2 vs 1.9 +/- 0.3 muU/mL, respectively"
  • Effect of chromium on the insulin resistance in patients with type II diabetes mellitus - Folia Med (Plovdiv). 2005;47(3-4):59-62 - "We found a significant decrease of the immune-reactive insulin and the insulin resistance index after a two-month application of chromium 30 microg daily (1 tablet of chrome picolinate) ... Chromium included early in the complex therapy of diabetes is beneficial in the reduction of the degree of insulin resistance"
  • Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients - Int J Vitam Nutr Res. 2004 May;74(3):178-82 - "study group received 200 microg of chromium twice a day for a three-week period ... Significant differences in the fasting blood level of glucose compared to the baseline (190 mg/dL vs 150 mg/dL, p < 0.001) were found at the end of the study. HbA1c also improved from 8.2% to 7.6% (p < 0.01). Total cholesterol was also reduced from 235 mg/dL to 213 mg/dL (p < 0.02). A trend towards lowered triglyceride levels was also observed (152 mg/dL vs 136 mg/dL)"