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Anti-aging Research > Chromium.
Chromium
Specific Recommendations:
News & Research:
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Chromium
picolinate may lessen inflammation in diabetic nephropathy; Supplement
linked to decreased protein in the urine of diabetic mice - Science
Daily, 9/22/10 -
"mice who received the supplement had lower levels
of albuminuria (protein in the urine), an indication of kidney disease ...
the treated diabetic mice, who were fed the diet with chromium picolinate,
excreted about half as much albumin compared to their untreated diabetic
counterparts"
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Chromium ingredient may have diabetes benefits: study - Nutra USA, 6/11/08 -
"This suggests that [niacin-bound chromium] is more
effective form of [chromium (III) ion] in preventing vascular inflammation in
diabetic rats, and thereby, can potentially reduce risk of CVD in diabetes ...
ChromeMate is also highly effective in helping maintain healthy blood sugar
levels and body weight, which is important for people with diabetes. Given the
close link between diabetes and cardiovascular disease, ChromeMate represents a
triple benefit in promoting good health" - See
chromium supplements at Amazon.com.
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Chromium ingredient may lower blood pressure: study - Nutra USA, 5/15/08 -
"niacin-bound
chromium III (NBC)
may act as an ACE inhibitor, which work by inhibiting the conversion of
angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving
blood flow and blood pressure" - I've been told that niacin-bound
chromium is sold as
ChromeMate®.
See
chromium supplements at Amazon.com.
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Dangers
of Chromium? - Dr. Weil, 4/21/08 - "The possibility
of DNA damage was suggested by studies of chromium picolinate in cell cultures.
There is no evidence of such an effect in any living organism. To follow-up on
the cell culture results, researchers at New York University studied the effects
of 400 micrograms of chromium picolinate over an eight week period in 10
overweight women and found no sign of DNA damage"
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Get the diet scoop: 6 promising supplements, 6 to avoid - CNN, 2/16/07 -
"promising ...
Caffeine ... EGCG
...
Chromium ... Conjugated
Linoleic Acid (CLA) ...
5-HTP ... L-dopa or
L-tyrosine"
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Research Affirms the Benefits of Combination of Chromium Picolinate and
Biotin for Improving Blood Sugar in People with Type 2 Diabetes -
Doctor's Guide, 1/8/07 - "A significant decrease in
fasting glucose levels of 4.67 mmol/L and postprandial glucose levels of
5.77 mmol/L was seen in patients taking chromium picolinate. The study
showed that blood glucose levels continued to improve each year throughout
the six years of the study"
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Research Affirms the Benefits of Combination of Chromium Picolinate and
Biotin for Improving Blood Sugar in People with Type 2 Diabetes -
Doctor's Guide, 12/20/06 - "The 30-day study
examined 36 overweight or obese poorly controlled patients with type 2
diabetes taking Diachrome who were already receiving oral anti-diabetic
drug(s). The results also showed a significantly greater reduction in the
total area under the curve for glucose (AUCg) during the oral glucose
tolerance test (OGTT) for the treatment group (mean change -9.7%) compared
with the placebo group (mean change +5.1%)"
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Chromium Picolinate Supplements Improve Glycemic Control - Physician's
Weekly, 11/13/06 - "Patients who received 1,000 µg
CrPic demonstrated significant improvements in insulin sensitivity and
glucose control when compared with placebo. Patients in the CrPic arm also
gained less weight (0.9 kg vs 2.2 kg) than those in the placebo arm and had
a smaller increase in body fat (0.12% vs 1.17%)"
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Chromium for Diabetes: Evidence of Benefits Grows - New Hope Natural
Media Online, 10/23/06 - "Compared with those who
took glipizide and placebo, people taking glipizide plus chromium (500 mcg
twice a day as chromium picolinate) experienced multiple benefits, including
significantly improved insulin sensitivity, less weight gain, less abdominal
fat, lower percent body fat, and lower glycohemoglobin (an indicator of
sugar-induced damage to tissues caused by diabetes)"
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Supplementation With Chromium Picolinate Improves Glycemic Control,
Attenuates Weight Gain - Doctor's Guide, 8/9/06 -
"Blood sugar levels of study participants taking
chromium picolinate in combination with the antidiabetic medication dropped
significantly compared to the group taking the medication plus placebo ...
Study participants taking chromium picolinate also experienced significantly
lower abdominal body fat accumulation than the group taking medication and
placebo, and experienced less overall weight gain" - See
chromium supplements at Amazon.com.
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Chromium Improves Glycemic Control When Sulfonylurea Is Insufficient -
Medscape, 8/3/06 - "By the end of the randomized
treatment period, mean fasting glucose had decreased by 31.0 mg/dL in the
CrPic group, which was significantly superior to the mean 11.3 mg/dL
decrease in the placebo group ... Participants receiving placebo gained
weight and percent body fat during the randomized treatment period, whereas
subjects receiving CrPic experienced an increase in fat-free mass vs
baseline. Only subjects receiving placebo had increases in total abdominal,
visceral, and abdominal subcutaneous fat"
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Chromium supplement offers diabetes hope – animal study - Nutra USA,
2/7/06 - "Obese rats treated with chromium
picolinate had significantly improved glucose disposal rates"
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Chromium Picolinate Linked With Reduced Carbohydrate Cravings in People With
Atypical Depression - Doctor's Guide, 9/29/05 -
"65% of the chromium picolinate patients with high
carbohydrate craving versus 33% of those receiving placebo had significantly
greater improvements on total HAM-D-29 scores (p < 0.05). HAM-D-29 is a
standard tool commonly used in assessing severity of symptoms in depressed
patients"
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Study Results Show Diachrome(R) Improves Poorly-Controlled Blood Sugar
Levels for People on Antidiabetic Prescription Medications - Doctor's
Guide, 9/13/05 - "Study participants taking
Diachrome with one or more antidiabetic medications saw an average range of
0.7 - 1.9% point reduction in HbA1c levels. The study also showed that
insulin resistance was significantly reduced (P<0.05) in those taking
thiazolidinediones and Diachrome ... Diachrome is a nutritional supplement
specifically formulated for people with diabetes. It contains 600 mcg of
chromium as Chromax(R) chromium picolinate and 2 mg of biotin" - See
chromium supplements at Amazon.com
and
biotin at Amazon.com.
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Supplemental Chromium Picolinate and Biotin Appear to Decrease Blood Glucose
and Lipid Levels in Type 2 Diabetics: Presented at ADA - Doctor's Guide,
6/17/05 - "Our most important finding is that
chromium picolinate and biotin help to decrease hemoglobin A1c [HbA1c]
values in poorly controlled diabetics ... 600 mcg chromium picolinate and
biotin 2 mg/per day" - See
chromium supplements at Amazon.com
and
biotin at Amazon.com.
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New Trial Shows Chromium Picolinate Reduces Weight Gain Associated with
Diabetes Medication - Doctor's Guide, 6/16/05 -
"The study participants who took 1,000 mcg of
Chromax(R) chromium picolinate in combination with the antidiabetic
medication experienced significantly lower body fat accumulation (0.12%)
than the group taking medication and placebo (1.1%), particularly in the
abdomen area. The study also found those taking chromium gained less weight"
- Chromium
Supplementation May Not Improve Impaired Glucose Tolerance
- Medscape, 3/1/05 - "We found no beneficial effect
of chromium supplementation in the treatment of people with IGT despite
increases in serum chromium levels, which suggested an adequate dosage
regimen"
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Novel Fiber Limits Sugar Absorption - Life Extension Magazine, 9/04 -
"Life Extension recommends that people seeking to
lose weight consume the following supplements: ... Chromium polynicotinate
600-1000 mcg daily ... Conjugated linoleic acid (CLA)
3000-4000 mg daily ... PGX™ highly viscous fiber
blend 1000-3000 mg 5-10 minutes before each meal with 8-16 ounces of water
... Consider asking your doctor to prescribe 500 mg two to three times daily
of the insulin-normalizing drug metformin"
- Low Chromium Linked
to Heart Disease Risk in Patients With Diabetes
- Medscape, 9/3/04 -
"Our results suggest that diabetic men with CVD have
lower toenail chromium than healthy control subjects"
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Chromium: An Element Essential to Health - Life Extension Magazine, 8/04
- "By interacting with proteins and nucleic acids,
excess glucose molecules wreak havoc with tissue elasticity and normal
function.33 Thus, controlling blood sugar may actually put the brakes on the
aging process, and should be an essential component of any life-extension
strategy"
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Chromium Picolinate Supplementation Linked With Reduced Chromium Picolinate
Supplementation Linked With Reduced Carbohydrate Cravings Associated With
Atypical Depression - Doctor's Guide, 6/2/04 - [WebMD]
"daily supplementation with 600 mcg of chromium as
chromium picolinate, significantly reduced carbohydrate cravings compared to
placebo, and improved other symptoms such as mood swings, fatigue and weight
gain perception"
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What You Don’t Know About Blood Sugar - Life Extension Magazine, 1/04 -
"it now appears that optimal fasting blood glucose
levels should probably be under 86 mg/dL ... Chromium supplements have been
shown to reduce blood glucose significantly.70-74 The dose used in human
studies ranges from 200 to 1000 mcg of elemental chromium a day, with best
results occurring when 400 mcg or more of chromium is taken daily"
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The Chromium Connection - Natural Foods Merchandiser, 9/03 -
"The body requires certain nutrients to control
glucose metabolism, especially chromium, zinc
and vitamins B and C
... Diabetes is devastating because of its
consequences. The condition often leads to hypertension, lipid disorders,
cardiovascular disease, blindness, skin problems, nerve damage, kidney
disorders and loss of limbs. Although it appears chromium picolinate may
benefit your customers with type 2 diabetes, supplementation represents just
one facet of treatment"
- Chromium Supplements
Appear to Improve Glucose Sensitivity in Diabetics
- Medscape, 8/29/03 - "We think that chromium
picolinate can influence a person's
diabetic treatment so that levels of insulin required may be reduced ...
HbA1c levels decreased from 9.5% to 9% during a six-month period in patients
receiving a higher dose of the supplement, a difference that was
statistically significant ... The study also showed a significant reduction
in cholesterol levels and trends for improvement in triglycerides in both
chromium picolinate groups as well as a reduction in blood pressure in all
groups"
- Chromium Effective for
Common Type of Depression - New Hope Natural Media, 4/10/03 -
"15 people suffering from atypical
depression, who had been off of antidepressant medication for at least
seven days, were randomly assigned to receive chromium picolinate or a
placebo for eight weeks. The dose was 400 mcg per day for the first two
weeks, then 600 mcg per day for the remainder of the study ... Seventy
percent (7 of 10) of those receiving chromium responded to the treatment,
whereas none of the five individuals in the placebo group had a positive
response. Although the number of participants in the study was small, the
difference in outcome between the chromium and placebo groups was highly
statistically significant. Moreover, in 60% of those receiving chromium, the
depression went into remission"
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Octacosanol Beats Statins - Dr. Janson, 4/02 -
"Chromium supplements in the range of 200 to 400 mcg
daily reduce total cholesterol and raise HDL levels, and up to 1000 mcg also
help control blood sugar levels"
- Could Chromium
Picolinate Cause Cancer? - WebMD, 12/11/01
- Can a Mix of
Chromium and Biotin Help Diabetics Control Blood Sugar?
- WebMD, 10/15/01 - "when chromium and biotin are
present together, they have more of a response than what would be expected
by adding their effects separately. "As soon as you put those two together,
you get a much greater increase in glucose metabolism,""
Abstracts:
-
Effects of chromium
supplementation on oxidative Stress biomarkers - Int J Vitam Nutr Res 2021
May 20 - "Overall, this meta-analysis demonstrated that
chromium supplementation increased GSH without any significant changes in the
mean of GPX, MDA, TAS, TBARS, CAT and SOD" - See
chromium supplements at Amazon.com.
-
Body Composition Changes
in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a
Brief Review (.pdf) - Nutrients. 2018 Dec 3;10(12) - "There are a few
dietary supplements that appear to help preserve LBM during weight loss or to
reduce the loss of LBM as compared to diet alone. One such dietary supplement
that appears to have this “LBM sparing” effect is chromium picolinate. For the
reasons shared in this paper, it seems logical to include CrP as part of any
reduced calorie (diet) plan as a means of keeping metabolically active LBM.
Weight loss without CrP may be at the cost of LBM, thus, this adjunctive
strategy appears worthy of further research and applied practice. A
comprehensive approach, integrating evidence-guided macronutrient and calorie
intake, resistance exercise, and chromium picolinate may be the most effective
approach to preserving or increasing lean body mass while maximizing body fat
mass reductions." - [Nutra USA] - See chromium
picolinate at Amazon.com.
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Effects of an amylopectin
and chromium complex on the anabolic response to a suboptimal dose of whey
protein - J Int Soc Sports Nutr. 2017 Feb 8 -
"muscle protein synthesis (FSR) ... amylopectin/chromium (ACr) complex ...
consumed 6 g whey protein + 2 g of the amylopectin-chromium complex (WPACr) or 6
g whey protein (WP) after an overnight fast ... These data indicate that the
addition of ACr to a 6 g dose of whey protein (WPACr) increases the FSR response
beyond what is seen with a suboptimal dose of whey protein alone" - [Nutra
USA] - See NOW Sports Waxy Maize Powder,
5.5-Pound at Amazon.com and
chromium supplements at Amazon.com.
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Supplementation of
Diabetic Rats with Leucine, Zinc, and Chromium: Effects on Function and
Histological Structure of Testes - Int J Vitam Nutr Res. 2016 Jul 5:1-11 -
"Administration of nutritional supplements to the
diabetic rats improved testes morphology and reversed, although not completely,
impairment of spermatogenesis. Treatment with nutritional supplements increased
testicular length, height, width, and volume. All treatments increased the
number of live sperm and the total number of epididymal sperm. Furthermore,
nutritional supplements increased diameter of tubules, height of epithelium, and
the number of cells in seminiferous tubules. These alleviating effects were more
pronounced in animals treated with the leucine-zinc-chromium combination. The
present results demonstrate beneficial effects of zinc, leucine, and chromium
supplements to improve testes morphology and to restore spermatogenesis in type
2 diabetic rats" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram).
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Risk of Type
2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements - J
Nutr. 2015 Oct 7 - "Compared with nonusers, the odds of
having T2D (HbA1c ≥6.5%) were lower in persons who consumed chromium-containing
supplements within the previous 30 d than in those who did not (OR: 0.73"
- See
chromium supplements at Amazon.com.
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Beneficial effects of oral
chromium picolinate supplementation on glycemic control in patients with type 2
diabetes: A randomized clinical study - J Trace Elem Med Biol. 2015 Oct -
"A four month controlled, single blind, randomized trial
was performed with 71 patients with poorly controlled (hemoglobin A1c
[HbA1c]>7%) T2DM divided into 2 groups: Control (n=39, using placebo), and
supplemented (n=32, using 600μg/day CrPic) ... CrPic supplementation
significantly reduced the fasting glucose concentration (-31.0mg/dL supplemented
group; -14.0mg/dL control group; p<0.05, post- vs. pre-treatment, in each group)
and postprandial glucose concentration (-37.0mg/dL in the supplemented group;
-11.5 mg/dL in the control group; p<0.05). HbA1c values were also significantly
reduced in both groups (p<0.001, comparing post- vs. pre-treatment groups).
Post-treatment HbA1c values in supplemented patients were significantly lower
than those of control patients. HbA1c lowering in the supplemented group
(-1.90), and in the control group (-1.00), was also significant, comparing pre-
and post-treatment values, for each group (p<0.001 and p<0.05, respectively) ...
HDL-c and LDL-c were significantly lowered, comparing pre- and post-treatment
period, in the control group" - [Nutra
USA]
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Chromium
Supplementation and the Effects on Metabolic Status in Women with Polycystic
Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial - Ann
Nutr Metab. 2015 Jul 31 - "randomized to receive 200 µg
chromium picolinate supplements (n = 32) or placebo (n = 32) for 8 weeks ...
Chromium supplementation in women with PCOS resulted in significant decreases in
serum insulin levels (-3.6 ± 7.4 vs. +3.6 ± 6.2 µIU/ml, p < 0.001), homeostasis
model of assessment-insulin resistance (HOMA-IR; -0.8 ± 1.6 vs. +0.9 ± 1.5, p <
0.001), homeostatic model assessment-beta cell function (HOMA-B; -15.5 ± 32.3
vs. +13.6 ± 23.1, p < 0.001), and a significant increase in quantitative insulin
sensitivity check index (QUICKI) score (+0.02 ± 0.03 vs. -0.008 ± 0.02, p =
0.001) compared with the placebo. In addition, a trend toward a significant
effect of chromium supplementation on decreasing serum triglycerides (-12.4 ±
74.4 vs. +15.2 ± 32.4 mg/dl, p = 0.05), very low-density lipoprotein-cholesterol
(-2.5 ± 14.9 vs. +3.0 ± 6.5 mg/dl, p = 0.05), and cholesterol concentrations
(-8.6 ± 21.9 vs. +0.7 ± 22.4 mg/dl, p = 0.09) was seen"
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Systematic
review and meta-analysis of the efficacy and safety of chromium supplementation
in diabetes - J Clin Pharm Ther. 2014 Mar 17 -
"Overall, chromium mono- and combined supplementation significantly improved
glycaemic control (mean difference for HbA1c -0.55% ... chromium monotherapy
significantly reduced triglycerides and increased HDL-C levels. The effects on
glucose and triglycerides levels were shown especially with chromium picolinate.
Glycaemic control may improve with chromium monosupplementation of more than 200
μg daily. HbA1c and FPG also improved in patients with inadequate glycaemic
control at baseline. The risk of adverse events did not differ between chromium
and placebo"
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Chromium
supplementation in overweight and obesity: a systematic review and meta-analysis
of randomized clinical trials - Obes Rev. 2013 Mar 18 -
"Electronic searches were conducted in Medline, Embase,
Amed and The Cochrane Library ... A meta-analysis of 11 studies showed a
statistically significant difference in weight loss favouring chromium over
placebo (mean difference (MD): -0.50 kg; 95% confidence interval (CI): -0.97,
-0.03). There was a high statistical heterogeneity. Adverse events included
watery stools, vertigo, headaches and urticaria. The evidence from available
RCTs shows that chromium supplementation generates statistically significant
reductions in body weight"
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Chromium
attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice
- Biochem Biophys Res Commun. 2010 May 27 - "Chromium
supplementation prevented progression of NAFLD and the beneficial effects were
accompanied by reduction of hepatic triglyceride accumulation, elevation of
hepatic lipid catabolic enzyme, improvement of glucose and lipid metabolism,
suppression of inflammation as well as resolution of oxidative stress, probably
through enhancement of insulin signaling. Our findings suggest that chromium
could serve as a hepatoprotective agent against NAFLD"
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Improved cognitive-cerebral function in older adults with chromium
supplementation - Nutr Neurosci. 2010 Jun;13(3):116-22 -
"In a placebo-controlled, double-blind trial, we
randomly assigned 26 older adults to receive either chromium picolinate
(CrPic) or placebo for 12 weeks ... Although learning rate and retention
were not enhanced by CrPic supplementation, we observed reduced semantic
interference on learning, recall, and recognition memory tasks. In addition,
fMRI indicated comparatively increased activation for the CrPic subjects in
right thalamic, right temporal, right posterior parietal, and bifrontal
regions. These findings suggest that supplementation with CrPic can enhance
cognitive inhibitory control and cerebral function in older adults at risk
for neurodegeneration"
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Phenotype of subjects with type 2 diabetes mellitus may determine clinical
response to chromium supplementation - Metabolism. 2007
Dec;56(12):1652-5 - "Sixty-three percent of the
subjects with type 2 diabetes mellitus responded to the Cr treatment as
compared with 30% with placebo ... Subject phenotype appears to be very
important when assessing the clinical response to Cr because baseline
insulin sensitivity was found to account for nearly 40% of the variance in
the clinical response to Cr"
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Effect of Chromium Supplementation on Glucose Metabolism and Lipids: A
Systematic Review of Randomized Controlled Trials - Diabetes Care. 2007
May 22 - "There was no benefit in individuals
without diabetes ... Chromium supplementation significantly improved
glycemia among patients with diabetes"
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The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic
Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A
Placebo-Controlled, Double-Blinded, Randomized Trial - Diabetes Technol
Ther. 2006 Dec;8(6):636-643 -
"randomized to receive 600 microg of chromium as
chromium picolinate and biotin (2 mg/day) ... supplementation with a
combination of chromium picolinate and biotin in poorly controlled patients
with diabetes receiving antidiabetic therapy improved glucose management and
several lipid measurements. Chromium picolinate/ biotin supplementation may
represent an effective adjunctive nutritional therapy to people with poorly
controlled diabetes with the potential for improving lipid metabolism"
-
Chromium picolinate supplementation attenuates body weight gain and
increases insulin sensitivity in subjects with type 2 diabetes -
Diabetes Care. 2006 Aug;29(8):1826-32 -
"1,000 mug Cr as CrPic ... CrPic supplementation in
subjects with type 2 diabetes who are taking sulfonylurea agents
significantly improves insulin sensitivity and glucose control. Further,
CrPic supplementation significantly attenuated body weight gain and visceral
fat accumulation compared with the placebo group" - See
chromium supplements at Amazon.com.
-
The influence of chromium chloride-containing milk to glycemic control of
patients with type 2 diabetes mellitus: a randomized, double-blind,
placebo-controlled trial - Metabolism. 2006 Jul;55(7):923-7 -
"one group to receive chromium-containing milk
powder (chromium 200 mug/20 g milk powder) and the other to receive placebo
twice a day for 16 weeks ... The chromium group demonstrated a lower FPG and
fasting insulin (-38.1 +/- 9.2 vs 63 +/- 8. 5 mg/dL and -1.7 +/- 0.2 vs 1.9
+/- 0.3 muU/mL, respectively"
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Effect of chromium on the insulin resistance in patients with type II
diabetes mellitus - Folia Med (Plovdiv). 2005;47(3-4):59-62 -
"We found a significant decrease of the
immune-reactive insulin and the insulin resistance index after a two-month
application of chromium 30 microg daily (1 tablet of chrome picolinate) ...
Chromium included early in the complex therapy of diabetes is beneficial in
the reduction of the degree of insulin resistance"
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Effect of chromium supplementation on blood glucose and lipid levels in type
2 diabetes mellitus elderly patients
- Int J Vitam Nutr Res. 2004 May;74(3):178-82 -
"study group received 200 microg of chromium twice a
day for a three-week period ... Significant differences in the fasting blood
level of glucose compared to the baseline (190 mg/dL vs 150 mg/dL, p <
0.001) were found at the end of the study. HbA1c also improved from 8.2% to
7.6% (p < 0.01). Total cholesterol was also reduced from 235 mg/dL to 213
mg/dL (p < 0.02). A trend towards lowered triglyceride levels was also
observed (152 mg/dL vs 136 mg/dL)"
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