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Anti-aging Research > Vitamin E
Vitamin E
Specific Recommendations:
News & Research:
-
Vitamin
E can boost immunotherapy responses by reinvigorating dendritic cells -
Science Daily, 4/14/22 - "Patients with melanoma who
took vitamin E while on anti-PD-1/PD-L1 checkpoint inhibitors had significantly
improved survival compared to patients who didn't take vitamin E or
multivitamins. This finding was replicated in an independent mixed cohort of
patients with breast, colon and kidney cancers. However, patients taking vitamin
E while being treated with chemotherapy did not experience the same benefits,
suggesting the effects were unique to chemotherapy" - See
vitamin E at Amazon.com.
-
Vitamins C and E Linked to
Reduced Risk for Parkinson's Disease - Medscape, 1/12/21 -
"total antioxidant capacity (also known as NEAC) ...
After adjusting the data for potential confounders, the researchers found that
the risk for PD was 32% lower among people in the highest tertile of vitamin E
intake, compared with those in the lowest tertile. Participants in the highest
tertile of vitamin C intake, compared with those in the lowest tertile, also had
a 32% lower risk for PD ... Furthermore, participants in the highest tertile of
vitamin E and C intake had a 38% lower risk for PD compared with those in the
lowest tertile. The researchers found no association, however, between dietary
beta-carotene or NEAC and risk for PD" - See American Health Ester-c With Citrus
Bioflavonoids 500 Mg, 240 Count and
Jarrow FamilE (contains all eight members
of the vitamin E family, includes Tocomin) at Amazon.com.
-
Vitamin
E needed for proper nervous system development - Science Daily, 9/21/20 -
"Zebrafish share a remarkable similarity to humans at
the molecular, genetic and cellular levels, meaning many findings are
immediately relevant to humans. Embryonic zebrafish are of special interest
because they develop quickly, are transparent and are easy to care for ... In an
embryo, a brain primordium and the neural tube appear early and will form the
nervous system and "innervate" -- supply with nerves -- all organs and body
structures. Without vitamin E, the zebrafish embryos showed neural tube defects
and brain defects ... They were kind of like folic acid-deficient neural tube
defects, and now we have pictures to show the neural tube defects and brain
defects and that vitamin E is right on the closing edges of the cells that are
forming the brain ... Vitamin E is a group of eight compounds -- four
tocopherols and four tocotrienols -- distinguished by their chemical structure.
Alpha-tocopherol is what vitamin E commonly refers to and is found in
supplements and in foods associated with a European diet; gamma-tocopherol is
the type of vitamin E most commonly found in a typical American diet" -
See
Jarrow FamilE (contains all eight members
of the vitamin E family, includes Tocomin) at Amazon.com and
iHerb.
-
Vitamin
E found to prevent muscle damage after heart attack - Science Daily, 9/16/19
- "Unfortunately lasting damage to the heart muscle is
not uncommon following such an event ... As there is currently no drug available
that can reduce the cardiac damage caused by an overshooting inflammation after
reopening of a blocked coronary artery, the potential impact of our finding on
cardiovascular health would be significant" - Here's the abstract:
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Metabolic syndrome patients need more vitamin C to break cycle of antioxidant
depletion - Science Daily, 1/2/19 - "A higher intake of vitamin C is crucial
for metabolic syndrome patients trying to halt a potentially deadly cycle of
antioxidant disruption and health-related problems ... That's important news for
the estimated 35 percent of the U.S. adult population that suffers from the
syndrome ... A patient is considered to have metabolic syndrome if he or she has
at least three of the following conditions: abdominal obesity, high blood
pressure, high blood sugar, low levels of "good" cholesterol, and high levels of
triglycerides ... Findings published in Redox Biology suggest the type of eating
that leads to metabolic syndrome can prompt imbalances in the gut microbiome,
with impaired gut function contributing to toxins in the bloodstream, resulting
in vitamin C depletion, which subsequently impairs the trafficking of vitamin E
... Vitamin C actually protects vitamin E, so when you have lipid peroxidation,
vitamin E is used up and vitamin C can regenerate it ... If you don't have the
vitamin C, the vitamin E gets lost and then you lose both of those antioxidants
and end up in this vicious cycle of depleting your antioxidant protection ...
The white blood cells are scrubbing with bleach and that destroys vitamin C ...
The body is destroying its own protection because it got tricked by the gut
dysbiosis into thinking there was a bacterial invasion" - See
vitamin C products at Amazon.com
and
vitamin E products at Amazon.com.
-
Preclinical testing suggests some antioxidants may be effective in treating
mitochondrial disease - Science Daily, 3/27/18 -
"Mitochondrial disease results from malfunctions in mitochondria, the
energy-generating "batteries" powering our cells. The disease is highly variable
and may affect potentially any organ and body system ... In the current study,
two compounds, the drug N-acetylcysteine (NAC) and vitamin E, showed compelling
results in mitochondrial disease model animals. The compounds prolonged lifespan
in mitochondrial complex I disease worms and protected complex I disease
zebrafish from brain damage. NAC also improved survival in the cells obtained
from a patient with mitochondrial complex I disease" - See
n-acetyl cysteine at Amazon.com
and
vitamin E products at Amazon.com.
-
The top ingredients for cognition, focus and mood - Nutra USA, 7/14/17 -
"omega-3 ... Phosphatidylserine (PS) ... B-vitamins ...
Vitamin E ... Lutein ... Citicoline ... Magnesium ... L-theanine ... Curcumin
... Resveratrol ... Blueberry anthocyanins ... Inositol-stabilized arginine
silicate ... Spearmint extract ... Ashwaganda ... Bacopa ... Teacrine"
-
Mechanism outlined by which inadequate vitamin E can cause brain damage -
Science Daily, 4/13/15 - "that zebrafish fed a diet deficient in vitamin E
throughout their life had about 30 percent lower levels of DHA-PC, which is a
part of the cellular membrane in every brain cell, or neuron. Other recent
studies have also concluded that low levels of DHA-PC in the blood plasma of
humans is a biomarker than can predict a higher risk of Alzheimer's disease ...
the deficient levels of vitamin E they were given, are equivalent to humans
eating a low vitamin E diet for a lifetime. In the United States, 96 percent of
adult women and 90 percent of men do not receive adequate levels of vitamin E in
their diet"
-
Pharmacological Potential
of Tocotrienols: A Review - Medscape, 1/29/15 - "In
contrast to αT, despite no evidence that deficiency of other vitamin E forms
would result in obvious clinical symptoms, accumulating evidence suggests that
γT, δT, and tocotrienols seem to have unique properties that are superior to αT
and relevant to prevention and therapy against chronic diseases even under
conditions with adequate αT status. It is noteworthy that these bioactivities of
tocopherols and tocotrienols including anti-inflammatory properties have been
identified by mechanistic studies and subsequently substantiated in some
preclinical models as well as clinical studies ... Hence, tocotrienols possess
neuroprotective, antioxidant, anti-cancer and cholesterol lowering properties.
Tocotrienols are thought to have more potent antioxidant and free radical
scavenging properties due to their better distribution in the lipid layers of
the cell membrane. In spite of the promising potential, the experimental
analysis of tocotrienols accounts for only a small portion of vitamin E
research" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Extra
vitamin E protected older mice from getting common type of pneumonia -
Science Daily, 12/16/14 - "The older mice fed a diet
containing extra amounts of vitamin E, the equivalent to about 200 IU/day
consumed by humans -- about 10 times the Recommended Daily Allowance but well
below the upper limit -- were far more resistant to the bacteria than the older
mice that had a normal amount of vitamin E in their diet ... Compared to the
mice that had normal amounts of vitamin E in their diet, the mice fed extra
vitamin E had ... 1,000 times fewer bacteria in their lungs ... Two times fewer
the number of white blood cells (neutrophils) ... The reduced numbers of
bacteria and white blood cells resulted in less lung damage in the older mice
who received extra vitamin"
-
Vitamin
E intake critical during 'the first 1,000 days' - Science Daily, 9/15/14 -
"A lifelong proper intake of vitamin E is also
important, researchers said, but often complicated by the fact that this
nutrient is one of the most difficult to obtain through diet alone. It has been
estimated that only a tiny fraction of Americans consume enough dietary vitamin
E to meet the estimated average requirement ... people who are highly motivated
to eat a proper diet consume almost enough vitamin E, but broader surveys show
that 90 percent of men and 96 percent of women don't consume the amount
currently recommended, 15 milligrams per day for adults"
-
Brain
saver: Vitamin E supplement helps 'redirect' blood during stroke - Science
Daily, 4/29/14 - "brain damage during a stroke can be
prevented by triggering the surrounding blood vessels to dilate and redirect the
blood flow around a blockage ... The blood vessel "redirect" is the result of 10
weeks' worth of supplementation with a little-known type of vitamin E called
tocotrienol. Tocotrienol appears to stimulate arteriogenesis -- or the
remodeling of existing blood vessels that can instantaneously expand in response
to a demand for oxygen-rich blood. This collateral blood supply can make a major
difference in stroke outcomes ... Tocotrienol, found naturally in palm oil, is a
vitamin E variant and currently available in stores as an oral nutritional
supplement. Because it doesn't appear to interfere with other stroke therapies
like blood thinners, or have any other side effects, Rink thinks that the
vitamin could someday become a common stroke prevention strategy"
-
Several
forms of vitamin E protect against memory disorders, study says - Science
Daily, 1/7/14 - "Studies investigating the link between
vitamin E and memory disorders have usually focused on a single form of vitamin
E, namely α-tocopherol, which is also used in vitamin E supplements. However,
vitamin E exists in eight different natural forms, tocopherols and tocotrienols,
all of which have antioxidant properties ... This recently published study
comprises a sample of 140 over 65-year-old Finnish persons with no memory
impairment at the onset of the study. During the eight-year follow-up, it was
discovered that higher total serum levels of vitamin E, and higher levels of
γ-tocopherol, β-tocotrienol and total tocotrienols in particular, seemed to
protect against memory disorders. According to the researchers, the results show
that the entire vitamin E family plays a role in memory processes" - See
mixed tocopherols at Amazon.com.
-
Vitamin E Improves Function
in Mild Alzheimer's Disease - Medscape, 12/31//13 -
"The study, conducted at 14 Veterans Affairs medical centers, assessed the
effect of vitamin E alone or with memantine on functional decline in 613
patients (97% men) with mild to moderate AD ... By random assignment, 152
patients received 2000 IU of α-tocopherol per day, 155 received 20 mg of
memantine per day, 154 received the combination of vitamin E and memantine, and
152 received placebo. They were followed for a mean of 2.3 years ... The annual
rate of decline in ADLs was reduced by 19% (P = .03) with vitamin E compared
with placebo" - [Science
Daily] [Abstract]
- Note: I'm still sticking with the mixed form of
vitamin E. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Oxidative Stress in
Prostate Cancer - Medscape, 9/17/13 - "Several
potential suggestions have been put forth to explain the results of the study,
which were contrary to the original prevention hypothesis. (i) The high dose of
vitamin E (400 IU), which was eight times higher than the 50 IU used in the ABTC
study, may abolish the preventive effect or even contribute to the increased
risk of PC demonstrated in the study.[82] (ii) Animal studies demonstrate cancer
preventive activity of γ- and δ-tocopherols, as well as for the naturally
occurring mixture of tocopherols, but not by α-tocopherol,[83] the source of
vitamin E used in the SELECT trail. (iii) Different individuals may respond
inconsistently to antioxidant treatment depending on specific, intrinsic genetic
risk factors"
-
Vitamin
E identified as potential weapon against obesity - Science Daily, 4/23/13 -
"The collaborators, from Case Western Reserve
University, the Cleveland Clinic Foundation and Cornell University, discovered
the essential nutrient vitamin E can alleviate symptoms of liver disease brought
on by obesity ... These findings may have a significant impact on public health
... as the vast majority of adults in the United States do not consume the
amount of vitamin E recommended by the National Institute of Medicine ... There
is currently no treatment for NASH, making it one of the most common reasons for
liver transplantation. Manor also points out that "NASH piggybacks on the two
great epidemics of our time: obesity and Type 2 diabetes.""
-
Excess
vitamin E intake not a health concern, study suggests - Science Daily,
4/15/13 - "a new review
concludes that biological mechanisms exist to routinely eliminate excess levels
of the vitamin, and they make it almost impossible to take a harmful amount ...
A much more important issue is that more than 90 percent of people in the U.S.
have inadequate levels of vitamin E in their diet ... On the other hand, vitamin
E performs many critical roles in optimum health. It protects polyunsaturated
fatty acids from oxidizing, may help protect other essential lipids, and has
been studied for possible value in many degenerative diseases"
- Note: That may be true but everything I've read claims that taking high
amounts of only the alpha-tocopherol lowers the other forms which may be as
important if not more important.
-
How
vitamin E can help prevent cancer - Science Daily, 3/16/13 -
"In this new work, researchers showed in prostate cancer
cells that one form of vitamin E inhibits the activation of an enzyme that is
essential for cancer cell survival. The loss of the enzyme, called Akt, led to
tumor cell death. The vitamin had no negative effect on normal cells ... Vitamin
E occurs in numerous forms based on their chemical structure, and the most
commonly known form belongs to a variety called tocopherols. In this study,
researchers showed that, of the tocopherols tested, the gamma form of tocopherol
was the most potent anti-cancer form of the vitamin ... The researchers began
the work with both alpha and gamma forms of the vitamin E molecule. Both
inhibited the enzyme called Akt in very targeted ways, but the gamma structure
emerged as the more powerful form of the vitamin"
-
Vitamin
E may lower liver cancer risk - Science Daily, 7/17/12 -
"China who were enrolled in the Shanghai Women's Health
Study (SWHS) from 1997-2000 or the Shanghai Men's Health Study (SMHS) from
2002-2006, two population-based cohort studies jointly conducted by the Shanghai
Cancer Institute and Vanderbilt University. Using validated food-frequency
questionnaires, the researchers conducted in-person interviews to gather data on
study participants' dietary habits. They compared liver cancer risk among
participants who had high intake of vitamin E with those with low intake ...
Vitamin E intake from diet and vitamin E supplement use were both associated
with a lower risk of liver cancer. This association was consistent among
participants with and without self-reported liver disease or a family history of
liver cancer"
-
Vitamin
E in diet protects against many cancers, study suggests - Science Daily,
4/23/12 - "Our message is that the vitamin E form of
gamma-tocopherols, the most abundant form of vitamin E in the American diet, and
delta-tocopherols, also found in vegetable oils, are beneficial in preventing
cancers while the form of vitamin E, alpha- tocopherol, the most commonly used
in vitamin E supplements, has no such benefit ... the most commonly used form of
vitamin E supplements, alpha-tocopherol, not only did not prevent prostate
cancer, but its use significantly increased the risk of this disease among
healthy men" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
More vitamin E linked to better mental function: Study - Nutra USA, 1/11/12
- "Alzheimer patients were 85% less likely to have the
highest levels of vitamin E, compared with people with normal cognitive function
... There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma,
delta) and four tocotrienols (alpha, beta, gamma, delta) ... the new study is
said to be the first to evaluate all the forms of vitamin E in relation to
Alzheimer’s disease ... Consumers should be taking a full spectrum vitamin E
especially for improving/ preserving cognitive health and performance" -
[Abstract]
-
Scientists identify an innate function of vitamin E - Science Daily,
12/20/11 - "Everyday activities such as eating and
exercise can tear the plasma membrane and the new research shows that vitamin E
is essential to repair. Without repair of muscle cells, for example, muscles
eventually waste away and die in a process similar to what occurs in muscular
dystrophy ... Vitamin E appears to aid repair in several ways. As an
antioxidant, it helps eliminate destructive byproducts from the body's use of
oxygen that impede repair. Because it's lipid-soluble, vitamin E can actually
insert itself into the membrane to prevent free radicals from attacking. It also
can help keep phospholipids, a major membrane component, compliant so they can
better repair after a tear"
-
Elevated Risk for
Prostate Cancer Found With Vitamin E - Medscape, 11/22/11 -
"vitamin E (400 IU) ... The overall risk for prostate
cancer was significantly elevated (by 17%) in the vitamin E group"
- Note: It's the alpha-tocopherol that's measured in IU like that and it's the
form in most supplement. Here's what I take:
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com
-
Combination Antioxidant
Therapy May Help Fatty Liver - Medscape, 11/7/11 -
"A combination of vitamin E and alpha lipoic acid (ALA) can improve the
inflammatory and steatosis scores in patients with nonalcoholic fatty liver
disease or nonalcoholic steatohepatitis ... combination therapy resulted in a
70% difference in change in tumor necrosis factors-alpha levels from baseline.
... ALA alone or vitamin E alone were not as effective ... Nonalcoholic fatty
liver disease is the most common liver disease in the world ... In the United
States, 20% of the general population and 75% to 92% of the morbidly obese
population suffer from the disease" - See
alpha lipoic acid products at Amazon.com
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Listen up! Antioxidants may slash risk of hearing loss, says study - Nutra
USA, 7/19/11 - "People with the highest average intakes
of vitamin A had a 47 percent reduced risk of moderate or greater hearing loss,
compared to people with the lowest average intakes ... In addition, increasing
dietary vitamin E intakes were linked with a 14 percent reduction in hearing
loss"
-
'Gifted'
natural vitamin E tocotrienol protects brain against stroke in 3 ways -
Science Daily, 7/5/11 - "This is one of the first
studies to provide evidence that a safe nutrient - a vitamin - can alter
microRNA biology to produce a favorable disease outcome ... Here, a natural
nutritional product is simultaneously acting on multiple targets to help prevent
stroke-induced brain damage. That is a gifted molecule" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Preventive use of one form of natural vitamin E may reduce stroke damage -
Science Daily, 7/5/11 - "Vitamin E occurs naturally in
eight different forms, and this work led by Ohio State University scientists is
focused on the tocotrienol form, also known as TCT. The commonly known form of
vitamin E belongs to a variety called tocopherols. TCT is not abundant in the
American diet but is available as a nutritional supplement. It is a common
component of a typical Southeast Asian diet ... In the study, 24 hours after a
stroke, lesions indicating brain tissue damage were about 80 percent smaller in
dogs that received supplementation than were the lesions in dogs that received
no intervention. Imaging tests showed that the treated animals' brains had
better blood flow at the stroke site as compared to untreated dogs' brains, a
difference attributed to tiny collateral blood vessels' ability to improve
circulation in the brain when blood flow stopped in more substantial vessels ...
In the study, 20 dogs were randomly assigned to one of two groups: those
receiving a placebo pill, and those receiving 200 milligrams of mixed
tocotrienols ... Additional examination of the affected brain tissue showed that
the TCT supplementation appeared to support arteriogenesis, a process by which
collateral arteries remodel themselves into larger vessels so they can bypass
the site of blockage" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin E tocotrienols show cholesterol benefits for healthy adults: Study -
Nutra USA, 6/29/11 - "Daily supplements of a palm
oil-based tocotrienol-rich product increased the ratio of HDL cholesterol to
total cholesterol – reported to be the most specific lipid risk factor for
cardiovascular disease (CVD) – by 14 percent in people over 50, compared to a
decrease of about 5 percent in the placebo group ... HDL cholesterol increases
of the magnitude observed in this study have been associated with a 22.5 percent
reduced risk of cardiovascular events" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin E tocotrienols may reduce cholesterol: RCT data - Nutra USA, 5/9/11
- "Supplements containing a mixture of tocotrienols –
forms of vitamin E – may reduce cholesterol levels by about 15 percent in people
with raised cholesterol ... Overall, there are eight forms of vitamin E: four
tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta,
gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in
supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the
most common form in the American diet ... After four months of supplementation,
the researchers noted a decrease in total cholesterol of 9 percent, with the
decrease recorded as 11 percent after six months ... In addition, LDL
cholesterol levels were decreased by 13 and 17.5 percent after four and six
months of supplementation, respectively" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin
E helps diminish a type of fatty liver disease in children, study suggests -
Science Daily, 4/27/11 - "Nonalcoholic fatty liver
disease (NAFLD) is the most common chronic liver disease among U.S. children.
NAFLD ranges in severity from steatosis (fat in the liver without injury) to
nonalcoholic steatohepatitis or NASH (fat, inflammation, and liver damage).
Fatty liver increases a child's risk of developing heart disease and liver
cirrhosis ... after 96 weeks of treatment, 58 percent of the children on vitamin
E no longer had NASH, compared to 41 percent of the children on metformin (a
diabetes drug), and 28 percent on placebo. Vitamin E was better than placebo
because it significantly reduced enlargement and death of liver cells ... These
results suggest that vitamin E improves or resolves NASH in at least half of
children, which we previously showed to be true in adults"
-
Long-Term Vitamin E Intake Linked to Reduced ALS Risk - Medscape, 3/29/11 -
"For dietary vitamin E intake, the adjusted RR comparing
the highest quartile with the lowest was 0.79"
-
Vitamin E May Affect
the Life Expectancy of Men - Medscape, 2/23/11
-
Essential oil pill prevents PMS, study suggests - Science Daily, 1/16/11 -
"Women who were given capsules containing 2 grams of a
combination of gamma linolenic acid, oleic acid, linoleic acid, other
polyunsaturated acids and vitamin E reported significantly eased PMS symptoms at
both 3 and 6 months after they began the treatment" - See
borage oil at Amazon.com
(GLA) and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
Oleic acid is omega-9 in which olive oil is a good source. Linoleic acid is
omega-6. Most Americans get about 10 to 20 times too much omega-6 to begin
with. I don't know why they included it. It makes me wonder about some of the
researchers. If they are showing a benefit, I would guess it's from the other
ingredients and not the omega-6. Gamma linolenic acid is an omega-6 also but
it's a form that most don't get enough of.
-
The science of the ‘next generation’ vitamin E - Nutra USA, 11/3/10 -
"there are eight forms of vitamin E: four tocopherols
(alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta).
Alpha-tocopherol (alpha-Toc) is the main source found in supplements and in the
European diet, while gamma-tocopherol (gamma-Toc) is the most common form in the
American diet ... In terms of benefits to the body, [tocotrienols] would protect
a larger area of membrane in a cell, than a tocopherol that stays stationary in
one place ... Heart disease ... Cancer ... Immune health ... Brain health ...
Male pattern baldness" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin E tocotrienols show immune boosting potential - Nutra USA, 10/27/10
- "TocominSupraBio ... there are eight forms of vitamin
E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha,
beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in
supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the
most common form in the American diet ... Results showed significant increases
in levels of the anti-TT antibody, interferon (IFN)-gamma and interleukin (IL)-4
in the tocotrienol group, compared with placebo" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin E in front line of prostate cancer fight - Science Daily, 10/23/10 -
"the research team have discovered a particular form of
T3, called gamma-tocotrienol (γ-T3), can successfully kill off the prostate
cancer CSCs ... Other research has found γ-T3 is also effective in suppressing
other types of cancer, including breast, colon, liver and gastric ... not all
vitamin E preparations had the active constituent" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Burn
injuries rapidly deplete vitamin E, study finds - Science Daily, 10/20/10 -
"An analysis of eight children with third-degree burns
over much of their body found they lost almost half of their stored vitamin E in
three weeks, even though they were being given about 150 percent of the
recommended daily allowance of vitamin E and other nutrients in a high-calorie
diet ... "the depletion of vitamin E may be a very significant problem in
patients with burn injury" and other forms of severe trauma"
-
Omega-3, vitamins C and E may boost pancreatic health - Nutra USA, 9/9/10 -
"consuming at least 850 milligrams of omega-3 fatty
acids per day was associated with a 53 percent reduction in the risk of
pancreatic cancer, compared to intakes of between 330 and 580 milligrams per day
... According to findings published in the International Journal of Cancer,
benefits were also observed for intakes of vitamin C and E, the highest average
intakes associated with 31 and 33 percent reductions, respectively, compared
with the lowest average intakes" - [Abstract]
-
Eating foods rich in vitamin E associated with lower dementia risk - Science
Daily, 7/12/10 - "the one-third of individuals who
consumed the most vitamin E (a median or midpoint of 18.5 milligrams per day)
were 25 percent less likely to develop dementia than the one-third of
participants who consumed the least (a median of 9 milligrams per day)"
-
High
blood levels of vitamin E reduces risk of Alzheimer's, Swedish study finds -
Science Daily, 7/7/10 - "High levels of several vitamin
E components in the blood are associated with a decreased risk for Alzheimer's
disease (AD) in advanced age, suggesting that vitamin E may help prevent
cognitive deterioration in elderly people. This is the conclusion reached in a
Swedish study ... Vitamin E is a family of eight natural components, but most
studies related to Alzheimer's disease investigate only one of these components,
+/--tocopherol ... We hypothesized that all the vitamin E family members could
be important in protecting against AD ... subjects with higher blood levels of
all the vitamin E family forms had a reduced risk of developing AD, compared to
subjects with lower levels. After adjusting for various confounders, the risk
was reduced by 45-54%, depending on the vitamin E component" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com
-
Finally, Vitamin E May Work -- And It's in the Liver - Medscape, 7/6/10 -
"We used to call this "fatty liver"; now it's got a
fancier name -- it's "nonalcoholic steatohepatitis." ... It turned out that only
the Vitamin E group managed to reach that level of significance"
-
Vitamin E may boost immune function: Mouse study - Science Daily, 5/20/10 -
"The animals were fed 0.1 per cent Tocomin 50 per cent
(Carotech), which is a mixture of tocotrienols and alpha-tocopherols, or a
control diet containing only tocopherol, for six weeks ... Older mice fed the
tocotrienol supplement displayed a greater level of lymphocyte proliferation, a
marker of how quickly white blood cells can reproduce in response to infection,
than old mice fed the control ... mice of both ages fed the tocotrienol
supplement had higher levels of the interleukin-1beta, a cytokine released by
immune cells (macrophages). ... There are eight forms of vitamin E: four
tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta,
gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in
supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the
most common form in the American diet" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Long-term use of vitamin E may decrease COPD risk, study finds - Science
Daily, 5/16/10 - "Long-term, regular use of vitamin E in
women 45 years of age and older may help decrease the risk of chronic
obstructive pulmonary disease (COPD) by about 10 percent in both smokers and
non-smokers"
-
Vitamin E may be new boon for liver disease - MSNBC, 4/28/10 -
"In the study published online in the New England
Journal of Medicine, 247 adults with advanced fatty liver disease were randomly
assigned to take a high dose of vitamin E (800 international units), the
diabetes drug Actos or dummy pills for nearly two years ... Biopsies before and
after treatment showed that liver function improved in 43 percent of those in
the vitamin E group compared with 19 percent in the placebo group ...
participants on the diabetes drug Actos also improved, but to a lesser degree
and with a drawback: gaining 10 pounds on average, which remained even after
they stopped taking the drug"
-
How one
form of natural vitamin E protects brain after stroke - Science Daily,
1/11/10 - "Our research suggests that the different
forms of natural vitamin E have distinct functions. The relatively poorly
studied tocotrienol form of natural vitamin E targets specific pathways to
protect against neural cell death and rescues the brain after stroke injury ...
Vitamin E occurs naturally in eight different forms. The best-known form of
vitamin E belongs to a variety called tocopherols. The form of vitamin E in this
study, tocotrienol or TCT, is not abundant in the American diet but is available
as a nutritional supplement. It is a common component of a typical Southeast
Asian diet" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Putting
limits on vitamin E - Science Daily, 12/31/09
-
Antioxidant compound reduced incidence of colorectal metachronous adenomas -
Science Daily, 12/7/09 - "The researchers randomized 411
participants to the placebo group or to receive an antioxidant compound --
specifically selenomethionnine 200 μg, zinc 30 mg, vitamin A 6,000 IU, vitamin C
180 mg and vitamin E 30 mg ... individuals who consumed antioxidants had a 40
percent reduction in the incidence of metachronous adenomas of the large bowel
... It is noteworthy that the benefit observed after the conclusion of the trial
persisted through 13 years of follow up"
-
Antioxidant vitamins may protect against female cancer - Nutra USA, 6/3/09 -
"for every 1,000 microgram increase per 1,000 kcal of
diet of beta-carotene was associated with a 12 per cent reduction in the risk of
endometrial cancer ... Similarly, for every 50 milligram increase per 1,000 kcal
of vitamin C the risk of endometrial cancer was reduced by 15 per cent, and for
every 5 milligram increase per 1,000 kcal of vitamin E the risk of endometrial
cancer was reduced by 9 per cent" - [Abstract]
-
High-Dose Vitamin E Slows Functional Decline in Alzheimer's Disease -
Medscape, 5/4/09 - "The clinical-effectiveness study
enrolled 540 patients with probable Alzheimer's disease (324 women) who had a
mean age of nearly 74 years. All were receiving 1 of the following
cholinesterase inhibitors: donepezil, rivastigmine, or galantamine (800 to 1000
U twice daily). In addition, 208 patients received vitamin E (800 to 2000
IU/day) ... Vitamin E treatment showed small to medium effect sizes in slowing
functional decline, the abstract reports. For vitamin E, the ADL Cohen's d
significantly increased, from 0.20 in year 1 (P = .02) to 0.42 by year 5 (P <
.001)"
-
Vitamin E may reverse male pattern baldness: Study - Nutra USA, 4/28/09 -
"Volunteers were randomly assigned to the palm
tocotrienol complex (total tocotrienol intake of 100 mg) or the placebo (soft
gelatin capsule containing 600 mg soy bean oil) ... Hair counts, measured by the
counting the number of hairs in a pre-selected 2x2 cm area, were found to
significantly increase by an average of 41.8 per cent in the tocotrienol group,
with eight volunteers experiencing greater than 50 per cent hair growth ...
There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta)
and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol is the main
source found in supplements ... While the majority of research on vitamin E has
focused on alpha-Toc, studies into tocotrienols account for less than one per
cent of all research into vitamin E" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Tocotrienol build-up in tumours ‘critical’ for anti-cancer benefits: Study -
Nutra USA, 3/31/09 - "the effects of gamma- and
delta-tocotrienol on mouse cancer cells ... the diet supplemented with 0.1 per
cent gamma-tocotrienol or 0.1 per cent delta-tocotrienol for four weeks ... In
conclusion, our results suggested that accumulation is critical for the
anti-tumour activity of tocotrienols" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin
E May Decrease Mortality Of Elderly Male Smokers, Yet Increase Mortality Of
Middle-aged Smokers - Science Daily, 2/14/09
-
Vitamin
E Shows Possible Promise In Easing Chronic Inflammation - Science Daily,
12/4/08 - "the larger take-home message of the study,
published in the December issue of the journal Experimental Physiology, is that
Vitamin E “may be beneficial in individuals with chronic inflammation, such as
the elderly or patients with type II diabetes or chronic heart failure"
-
Vitamin E may slash lung cancer risk: Study - Nutra USA, 10/31/08 -
"The researchers calculated that the highest average
intakes of alpha-tocopherol (more than 7.73 mg per day) were associated with a
53 per cent reduction in lung cancer risk, compared to the lowest average
intakes (less than 4.13 mg per day) ... When the researchers accounted for the
other tocopherols they observed no significant associations on lung cancer risk
for beta-, gamma, and delta-tocopherol" - [Abstract]
(see the abstract, I don't believe that last part is true on the gamma. - Ben
-
Optimal
Dose Of Vitamin E Maximizes Benefits, Minimizes Risk - Science Daily,
10/30/08 - "One of the most compelling studies of the
benefits of vitamin E is the Women’s Health Study, in which 40,000 healthy
women, 45 and older, took 600 IU vitamin E supplements or a placebo every other
day for 10 years. Women taking the supplements had 24 percent fewer deaths from
heart disease. Vitamin E’s protective effect appeared even stronger in women 65
and older. Those taking the vitamin experienced a 26 percent reduction in
cardiovascular events and a 49 percent reduction in cardiovascular deaths ...
Vitamin K in the liver appears to diminish as vitamin E increases" -
Note: Alpha-tocopherol is the only form of vitamin E that is measured in IU's.
See my vitamin E page for problems with just
taking the one form of vitamin E. For one thing, in addition to reducing
vitamin K it reduces the gamma-tocopherol form of vitamin E which may be as
important if not more important. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Prostate Cancer: Vitamin E, Selenium No Help - WebMD, 10/28/08 -
"That evidence included a 1998 Finnish study of whether
vitamin E could prevent lung cancer in some 30,000 smokers. It didn't, but men
taking vitamin E had 32% fewer prostate cancers ... I am afraid it will be the
end of the story for large trials of vitamin E and selenium to prevent prostate
cancer" - Note: Most of the vitamin E studies I've read on prostate
cancer indicated that only the gamma-tocopherol worked yet they spent $114
million on this study and used the cheapest synthetic dl-alpha-tocopherol
acetate form. How dumb was that? I don't know what the story on the selenium
was. Some say it's because people in the U.S. aren't deficient in selenium.
See my comments in my
10/29/08 newsletter.
-
Vitamin E May Help Alzheimer's Patients Live Longer, Study Suggests -
Science Daily, 4/15/08 - "people who took vitamin E,
with or without a cholinesterase inhibitor, were 26 percent less likely to
die than people who didn't take vitamin E"
-
Vitamin C can keep you healthy, looking younger - CNN.com, 2/27/08 -
"Pairing vitamins C and E is smart for another
reason: It may lessen your Alzheimer's risks by as much as 64 percent ..."
-
Vision:
Antioxidants May Cut Cataracts - New York Times, 2/12/08 -
"Compared with the one-fifth of women who consumed
the least antioxidants, the one-fifth who consumed the most reduced their
risk for cataracts by 14 percent with vitamin E and 18 percent with lutein"
-
Vitamin E for Vitality? - WebMD, 1/22/08 -
"people with high blood levels of vitamin E showed a milder decline in their
physical function test scores" - [Science
Daily] - Note: I feel that the reason the studies stress food as the
source is because you are getting the mixed form of vitamin E instead of the
alpha-tocopherol found in most supplements, which may lower the other forms.
-
Vitamin E Could Help 40% Of Diabetics Ward Off Heart Attacks - Science
Daily, 11/23/07 - "After 18 months of treatment,
people with the haptoglobin (Hp) 2-2 gene who took 400 International Units
(IU) of vitamin E daily had more than 50 percent fewer heart attacks,
strokes, and related deaths than Hp 2-2 patients who took a placebo pill.
40% of individuals with diabetes carry the Hp 2-2 gene"
- Note: Only the alpha-tocopherol form of vitamin E is measured in IUs and
I'm leery of only taking that form. See:
-
Vitamin E pills may cut heart disease risk in diabetics - Nutra USA,
10/19/07
-
Vitamin supplement use and risk for breast cancer: the Shanghai Breast
Cancer Study - Breast Cancer Res Treat. 2007 Oct 5 -
"a 20% reduction in breast cancer risk was observed
with vitamin E supplement use among women with low-dietary vitamin E intake
... A non-significant 20% risk reduction was observed among vitamin B
supplement users with low B dietary intake (OR = 0.8; 95% CI, 0.6-1.1).
Frequent use of a vitamin B supplement was adversely associated with breast
cancer risk among those with high dietary vitamin B intake (OR = 1.4"
-
Tocotrienol may protect against DNA damage, says study - Nutra USA,
9/24/07 - "There are eight forms of vitamin E: four
tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta,
gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in
supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is
the most common form in the American diet ... While the majority of research
on vitamin E has focused on alpha-Toc, studies into tocotrienols account for
less than one per cent of all research into vitamin E ... blood cells from
patients receiving the tocotrienol-rich supplement had significantly less
DNA damage after three and six months of supplementation than those in the
placebo group" - See my favorite
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin E Trials 'Fatally Flawed' - Science Daily, 9/23/07
-
Vitamin E May Protect Against Venous Thromboembolism in Women -
Medscape, 9/12/07 - "Of 482 women who had VTE during
follow-up, 213 were in the vitamin E group and 269 were in the placebo
group, yielding a significant 21% hazard reduction (relative hazard, 0.79;
95% confidence interval [CI], 0.66 - 0.94; P = .010). The hazard reduction
was 27% for unprovoked VTE (relative hazard, 0.73; 95% CI, 0.57 - 0.94; P =
.016)"
-
Vitamin E May Lower Blood Clot Risk - WebMD, 9/11/07 -
"Overall, women who took vitamin E were 21% less
likely to develop venous thromboembolism than women who did not, but the
reduction was more than double this (44%) among the women who had a history
of clots ... taking vitamin E appeared to cut the clot risk in half among
women with genetic mutations that increased their risk"
-
Industry must wake up to tocotrienol opportunities - Nutra USA, 8/1/07 -
"While the majority of research on vitamin E has
focused on alpha-Toc, studies into tocotrienols account for less than one
per cent of all research into vitamin E"
-
Vitamin E: Friend or Foe During Radiation Therapy? - Physician's Weekly,
7/16/07 - "Not only did it show that vitamin E
supplementation was of no benefit to patients, but it was also associated
with a nearly 40% increased risk of death when compared to study
counterparts who received a placebo. Vitamin E, despite what patients may
think, appears to be much more harmful for patients who have head and neck
cancer who are receiving radiation therapy"
-
Pro-vitamin E Shown To Be Active Against Breast Cancer Cells - Science
Daily, 12/9/06 - "pro-vitamin E or alpha-tocopheryl
succinate can reduce tumour volume in experimental animals with high levels
of HER2"
-
Vitamin E may protect against
cancer, heart ills - MSNBC, 11/22/06 -
"Men with the highest levels of vitamin E in their
blood were 18 percent less likely to die than those with the lowest levels,
the researchers found. They also had a 21-percent lower risk of death from
cancer, a 19-percent lower risk of dying from heart disease, and a
30-percent lower risk of death from other causes"
-
Antioxidant-rich Pecans Can Protect Against Unhealthy Oxidation -
Science Daily, 10/3/06 - "adding just a handful of
pecans to your diet each day may inhibit unwanted oxidation of blood lipids,
thus helping reduce the risk of heart disease. Researchers suggest that this
positive effect was in part due to the pecan's significant content of
vitamin E ... Pecans are especially rich in one form of vitamin E -- gamma
tocopherol"
-
What Makes Gamma Tocopherol Superior to Alpha
Tocopherol
- Life Extension Magazine, 4/06 - "vitamin E supplements should contain a
ratio of alpha tocopherol to gamma tocopherol that is closer to what is
found in nature ... For optimal supplementation, it would appear logical to
consume at least 200 mg of gamma tocopherol each day, in addition to around
400 IU of alpha tocopherol"
-
Nutritional Friend Or Foe? Vitamin E Sends Mixed Messages - Science
Daily, 3/3/06 - "We think that gamma-tocopherol may
have this kind of damaging effect on nearly every type of cell in the body"
-
Healthy Diet May Help Seniors' Vision - WebMD, 12/27/05 -
"People with above-average intakes of all four
antioxidants were 35% less likely to develop AMD during the study ...
Vitamin E and zinc stood out"
-
Meta-analysis Results Suggest High-Dose Vitamin E Increases All-Cause
Mortality - Medscape, 11/6/05 -
"there are several theories about why vitamin E
increases risk. One theory is that it increases bleeding risk, which would
increase the risk of hemorrhagic stroke, while another theory suggests that
at high doses vitamin E stops working like an antioxidant that mops up free
radicals that attack cells that line blood vessels and instead becomes a
prooxidant and actually promotes the production of free radicals ... Still
another scenario suggests that high-doses of vitamin E tend to destroy other
fat-soluble antioxidants"
-
Vitamin E: Alpha or Gamma? - Natural Food Merchandiser, 10/05 -
"Given these synergistic relationships and the
results of research to date, a mixed-tocopherol product seems to be the best
choice"
-
Low Vitamin E Serum Levels Correlate With Dementia Risk - Clinical
Psychiatry News, 10/05 - "those individuals in the
bottom tertile of vitamin E plasma levels were at significantly higher risk
not only of being demented (OR 2.6, 95% CI) but also of having impaired
cognitive function (OR 2.2, 95% CI), compared with the highest vitamin E
tertile"
-
High
Doses Of Vitamin E Boost Rat Survival Rate 40%; Brain Function,
Neuromuscular Gains - Science Daily, 9/5/05 -
"male mice showed a 40% increase in median lifespan
... 17% increase in maximal lifespan (to 136 weeks from 116 weeks) ...
increases in the ability to perform tests measuring neuromuscular
performance (high-wire tightrope) and cognitive exploratory activity
(T-maze)"
-
Vitamin E Boosts Lifespan, Brain Functioning - mercola.com, 9/2/05 -
"be sure to find a brand that contains
gamma-tocopherol, the most naturally occuring form of vitamin E, not
dl-alpha-tocopherol, the synthetic variety that's most commonly available in
most stores"
-
Are you getting enough vitamin
E? - MSNBC, 8/12/05 -
"Most supplements contain – and thus most research
looks at – the form of vitamin E known as alpha-tocopherol. However,
gamma-tocopherol is actually the major form in the American diet ... Some
studies show that blood levels of gamma-tocopherol are a good or better
indicator of heart and cancer risk. Gamma-tocopherol may even have unique
cancer-suppressing functions within cells. Some studies suggest that
alpha-tocopherol supplements may have the undesirable effect of reducing
blood and tissue levels of gamma-tocopherol"
-
Can
Rice Bran Oil Melt Away Cholesterol? - Science Daily, 5/12/05 -
"Vitamin E ... consists of both tocopherols and
tocotrienols ... the tocotrienols (TRF) seem to have greater antioxidant
properties ... taking any form of Vitamin E for a long time can be harmful
... The most effective dose in rats was 8 IU kg/day. Extrapolated to humans,
a person with an average body weight of 154 pounds would get around 560 IU"
-
Tocotrienol-Rich Rice Bran Oil A New Natural Cholesterol-Fighter -
mercola.com, 5/12/05 - "This good news certainly
supports other studies that have shown the antioxidant effects of
tocotrienols to be 40 to 60 times more effective than alpha tocopherol"
-
Boost In Immune Response Fights Common Cold - Science Daily, 4/24/05 -
"Nursing facility residents who consumed 200
International Units (IUs) of vitamin E daily for one year were less likely
to get the sniffles than those who took a placebo ... those who took the
moderate supplements were 20 percent less likely to contract upper
respiratory infections, such as colds"
-
Vitamin E Harms More Than It Helps - WebMD, 3/15/05 [Abstract]
- "All were over age 55. Half got high-dose vitamin
E -- 400 IU every day (about 400 milligrams) -- and half got fake pills that
looked the just the same ... Vitamin E was linked to a 13% higher risk of
heart failure and a 21% increased risk of hospitalization for heart failure"
- Note: The way I understand it, only the alpha tocopherol form (used in
most supplements) is measured in IU. So I assume they used that form for
this study. I've been saying for some time that taking just the alpha
tocopherol form causes more harm than good because it
lowers gamma tocopherol. See item 6 on my
home page. With all the evidence
against alpha tocopherol, I'm surprised they are still using it in studies
and I'm surprised how slow vitamin companies are to offer multi-vitamins
with mixed tocopherols/tocotrienols.
-
Vitamin E:
Which Type Best for Prostate Cancer? - WebMD, 3/1/05 -
"the men with the highest blood levels of alpha and
gamma tocopherol had lower prostate cancer risk. Men with the highest levels
of both forms of the vitamin were 30%-40% less likely to develop prostate
cancer as those with the lowest levels"
-
Vitamin E From Food
Sources May Reduce Risk of AD
- Medscape, 2/11/05 -
"High intake of vitamin E from food (tocopherol),
but not from supplements (which usually contain α-tocopherol), is inversely
associated with Alzheimer disease ... various tocopherol forms rather than
α-tocopherol alone may be important in the vitamin E protective association
with Alzheimer disease"
-
Vitamin E In Plant Seeds Could Halt Prostate, Lung Cancer, Says Purdue
Scientist - Science Daily, 12/30/04 -
"gamma-tocopherol, which occurs naturally in
walnuts, pecans, sesame seeds, and in corn and sesame oils, inhibits the
proliferation of lab-cultured human prostate and lung cancer cells"
-
Vitamin E in Food
May Fight Cancer - WebMD, 12/15/04 - "Most
supplements provide a different form of the vitamin, alpha-tocopherol ...
Gamma-tocopherol aced its lab tests. It inhibited the spread of prostate and
lung cancer cells without hurting the healthy cells ... Mixing several forms
of vitamin E -- including gamma-tocopherol -- was even better at blocking
cancer's spread"
-
Gamma-tocopherol halts cancer cells in lab study - Nutra USA, 12/15/04 -
"Gamma-tocopherol, found naturally in walnuts,
sesame seeds and corn, was found to hold back the proliferation of
lab-cultured human prostate and lung cancer cells, reports the team from
Purdue University in the 13 December online edition of the Proceedings of
the National Academy of Sciences ... This could indicate that the vitamin Could be used to target lung and prostate cancer cells without the damaging
side effects of chemotherapy"
-
Vitamin E,
Heart Disease, and Mortality - Dr. Murray's Natural Facts, 11/12/04
-
Carotech Communication Regarding Johns Hopkins vitamin E Meta-analysis
- NPI Center, 11/12/04 - "a high dosage of
alpha-tocopherol alone has been shown to deplete the body's
gamma-tocopherol. Despite alpha tocopherol's action as an antioxidant, gamma
tocopherol is required to effectively remove the harmful
peroxynitrite-derived nitrating species"
-
High-Dose
Vitamin E May Shorten Life Span - WebMD, 11/10/04 -
"too much vitamin E -- daily doses of 400 IU or more -- actually increases
the risk of dying"
- Note: Most vitamin E supplements are the d-alpha tocopherol or dl-alpha
tocopheryl (synthetic) form, which have been shown to deplete serum gamma
tocopherol and alpha tocotrienol. I've been saying for some time that
taking just the d-alpha tocopherol causes more harm than good (item 6 on my
home page).
-
CRN Questions Conclusions Reached by Researchers in Recent Vitamin E
Meta-Analysis - NPI Center, 11/10/04 -
"Most of the trials involved middle-aged to elderly
persons who had heart disease or other serious conditions or were at risk of
disease. The placebo groups had an ACM rate of 1022/10,000 and the high-dose
(defined by the researchers as 400 IU and up) vitamin E subjects had an ACM
increase of 39/10,000"
-
Vitamin E: Reducing Diabetes Risk? - Physician's Weekly, 11/8/04 -
"Although the improvement in insulin resistance was temporary, elevations in
alanine transferase liver enzyme were sustained throughout the study period"
-
Vitamin E +
Lycopene Fights Prostate Cancer - WebMD, 9/30/04 -
"a combination treatment with low-dose lycopene and
vitamin E had the strongest effect at slowing tumor growth -- a 73% slowing
of growth on the 42nd day of the test ... The next best results came from
the low dose of lycopene alone, which slowed tumor growth by 53% in the same
time frame"
-
Nourishing
Your Noggin - WebMD, 9/22/04 -
"For a long time, people believed that a common
component of vitamin E called alpha tocopherol was most important, but
another form called gamma tocopherol is definitely a protective antioxidant
in brain disorders"
-
Vitamin E review
- ConsumerLab.com, 8/25/04 -
"There are studies underway to determine whether
gamma-tocopherol (which is more abundant in the diet than alpha-tocopherol)
may be important for some of the beneficial effects associated with natural
vitamin E in the diet ... 32 products were purchased ... Five vitamin E
products failed"
-
Vitamin E May
Prevent Common Cold - WebMD, 8/17/04 -
"Participants in the vitamin E group who completed
the study had significantly fewer common colds and a 20% lower risk of
acquiring a cold than those in the placebo group"
-
Technical Communication from CAROTECH INC, Edison, NJ (In Response to the
latest Scientific Review on Vitamin E, published in the Archives of Internal
Medicine) - NPI Center, 8/1/04 -
"There are 8 forms of vitamin E in nature - 4 forms
of tocopherols and 4 forms of tocotrienols (alpha-, beta-, gamma- and
delta-tocopherol and corresponding tocotrienols). The idea that one single
form of vitamin E – alpha-tocopherol out of eight fractions is the “magic”
vitamin E and assuming that the other forms are worthless denies the very
fact that nature put these seven other tocopherols and tocotrienols out
there for a reason"
-
Vitamin E
Useless in Fighting Heart Disease - WebMD, 7/28/04 -
"vitamin E had no significant effect in reducing the risk of heart attack,
stroke, or heart-related death"
-
Study Shows Vitamins C And E Can Prevent Metabolic Damaage In Extreme
Exercise - Science Daily, 7/15/04 -
"ultramarathon runners who used supplements of
vitamins C and E for six weeks prior to their races totally prevented the
increase in lipid oxidation that is otherwise associated with extreme
exercise"
-
Higher Serum Vitamin E Levels Linked to Lower Prostate Cancer Risk
- Doctor's Guide, 3/30/04 -
"Compared with men in the lowest tertile of
alpha-tocopherol levels, men in the highest tertile were 53% less likely to
develop prostate cancer (P = .05). Men in the highest tertile of
gamma-tocopherol were 39% less likely to develop the cancer than those in
the lowest tertile"
-
Vitamins C and
E May Lower Alzheimer's Risk - WebMD, 1/20/04
-
Vitamins E and C May Fend Off Alzheimer's - HealthDay, 1/19/04 -
"those who took extra vitamin E and
C were about 60 percent less likely to develop
dementia
and other memory and thinking problems linked with
Alzheimer's as those who didn't use the two supplements ... The effect
appeared only in people who combined the two vitamins"
-
Vitamin E Helps People
with Sudden Hearing Loss - Healthwell Exchange Daily News, 10/2/03 -
"one group received vitamin E, 600 IU two times per
day, while the other did not. Treatment was considered successful when
hearing improved by 75% or more ... At follow-up examinations,
successful treatment was noted in 76% of those receiving vitamin E and 56%
of those not receiving vitamin E"
-
Vitamin E Supplements Effective Treatment for Mild Hypertension
- Doctor's Guide, 10/1/03 - "Vitamin E supplements
of 200 IU/day improved the
blood pressure status of 70 mild hypertensive
... Subjects who received vitamin E supplements had a 24% decrease in
systolic blood pressure compared to a 1.6% decrease among placebo controls"
-
Vitamin Supplements Improve Blood Vessel Function
- Physician's Weekly, 9/8/03 - "In a study where
children with
hyperlipidemia
were given doses of the antioxidants vitamins C
and E, researchers have found that the supplements can significantly improve
blood vessel function ... the test group received 500 mg of vitamin C and
400 IU of vitamin E daily. Both groups saw an 8% decline in LDL cholesterol
and the test group had significant improvement in endothelial function
comparable to the levels of normal healthy children"
-
Age-Related Disease: Reduce Risk with Vitamin E, Exercise
- Physician's Weekly, 8/25/03 -
"Free radical cells, which are unstable molecules
that damage cells and are believed to contribute to the development of
various diseases, were significantly reduced when exercise was combined with
taking vitamin E. Moreover, the combined strategies reduced the risk of
obesity, hypertension, and diabetes, all of which worsen free radical cell
damage. The researchers note that after age 40, the body produces more free
radicals and fewer natural antioxidants to fight them, and taking vitamin E
supplements can be beneficial to the well-being of patients"
-
Exercise, Vitamin E Combo Can Slow Aging - HealthDay, 8/11/03 -
"those who exercised regularly and took vitamin E
supplements became healthier and greatly decreased their levels of a blood
marker that signals destruction of certain cells ... people who didn't
exercise, but took vitamin E, had large decreases in oxidative stress and
blood pressure ... Cells, tissues and organs are damaged by the oxidation
caused by free radicals. Previous research has shown that free radicals play
a role in the development of cancer, obstructed arteries, Alzheimer's
disease and some 200 other diseases, as well as the aging process itself"
-
Can Vitamins Help Kids With High Cholesterol? - HealthDay, 8/11/03 -
"All of the participants followed the National
Cholesterol Education Program Step II diet for the entire six months of the
study ... After an initial six-week period, the participants were randomly
assigned to receive either 500 milligrams of
vitamin C and 400 international units of vitamin E per day or placebos
for the next six weeks ... The diet had no effect on endothelial dysfunction
... The vitamin supplements, however, improved endothelial function to
almost normal levels"
- [Abstract]
-
E and C May Give Older Women a Mental Edge - Natural Foods Merchandiser,
8/03 - "The women who had taken
vitamin C
and E supplements for more than 10 years scored an average of 1.5 years
younger in cognitive function than those not
taking vitamins. The results were even more marked for those with low
dietary vitamin E intake: Women with the lowest 30 percent of dietary
vitamin E intake who did not take supplements tested two years older in
mental function than women who compensated for low dietary intake with
antioxidant supplements"
-
Protecting Muscle Mass As You Age - Life Extension Magazine, 8/03 -
"researchers gave both young (age 23 to 35) and
elderly (age 66 to 78) men who were in an intensive exercise program either
1000 IU of vitamin E or a placebo daily for three months. The results showed
that both the young and older men who were taking the daily vitamin E
supplements had significantly less biochemical markers of free radical
damage when compared to the men who were taking placebo"
-
Vitamin E,
Exercise Prevent Aging Damage - WebMD, 7/31/03 -
"Whether they exercised or not, those taking vitamin E pills had the same
reduction in harmful substances known as free radicals -- unstable molecules
that damage cells and are believed to contribute to the development of some
200 different diseases, many of them age-related. The levels of a blood
marker that signals free-radical damage were cut in half ... Basically,
vitamin E prevents free radicals from bumping into cell walls and destroying
them"
-
What do you think of the
new study showing that antioxidants don’t cut the risk of heart disease
- Dr. Weil, 7/14/03 -
"If you want to supplement your diet, take a product
that provides as many members of this family of protective pigments as
possible: alpha-carotene, lutein, zeaxanthin, lycopene, etc. As for vitamin
E, most studies use synthetic alpha-tocopherol. I recommend using natural
vitamin E supplements that provide all four tocopherols and all four
tocotrienols"
-
Alpha-Tocopheryl Succinate Seen as Auxiliary Cancer Treatment -
AltMedicine.com, 5/22/03 -
"alpha-tocopheryl succinate has inhibited and killed
both human and rodent
cancer
cells in test tubes (in vitro) and later in the living body of rodents (in
vivo)—without causing normal cells to proliferate. So far, tests in living
human bodies have not been conducted"
-
NOW Foods Introduces Advanced Gamma E Complex - NPI Center, 5/22/03 -
"Gamma and alpha tocopherols must both be present in
the correct ratios to provide Vitamin E’s broad range of benefits"
-
Vitamin E Protects
Against Neurotoxicity From Cisplatin
- Medscape, 3/10/03 - "Among 27 patients who
completed six cycles of
cisplatin chemotherapy, the incidence of neurotoxicity was 30.7% in the
group receiving vitamin E compared with 85.7% in the unsupplemented group (P
< .01), and the neurotoxicity that did occur in the supplemented group was
less severe (P < .01)."
-
Is there anything that
I can do to aid recovery and reduce soreness [from exercise]?
- Dr. Murray - "Take 3,000-8,000 mg of
vitamin C and 400-800 IU of vitamin E in divided doses daily"
-
Vitamins C
and E may enhance effectiveness of insulin for diabetes
- University of California at Irvine, 1/29/03 -
"Boosting
insulin with
vitamins C and E may improve the drug's effectiveness for treating
diabetes ... the popular antioxidant supplements not only enhance
insulin's ability to reduce blood sugar, but also lower the risks of organ
damage that can occur despite insulin treatments"
-
Bad Boy in the
Blood: CRP - WebMD, 1/15/03 -
"You can lower your CRP levels by doing the same
things you would do to lower your cholesterol levels: lose weight, eat fewer
calories and a very low fat diet, take the cholesterol-lowering drugs known
as
statins, and the natural form of vitamin E"
-
Vitamins C and E
Improve Outcome in Critically Ill Surgical Patients
- New Hope Natural Media, 1/9/03 -
"Five-hundred and ninety-five people admitted to a
surgical intensive care unit (ICU), 91% of whom were victims of trauma, were
randomly assigned to receive standard care (control group) or standard care
plus
vitamins C and E. Vitamin E was given
orally in the amount of 1,000 IU three times per day, and vitamin C was
given intravenously in the amount of 1,000 mg three times per day ... The
incidence of multiple organ failure was significantly lower (by 57%) in the
group receiving antioxidants than in the control group (2.7% vs. 6.1%). In
addition, the average length of stay in the ICU was significantly lower (by
17%) in the antioxidant group. After 28 days, the mortality rate was 44%
lower in the antioxidant group than in the control group (1.3% vs. 2.4%),
but this difference was not statistically significant"
-
Antioxidant Vitamins
Improve Surgical Outcomes - Medscape, 12/20/02 -
"Compared with patients receiving standard care, those who received
antioxidant supplementation with alpha-tocopherol and
ascorbate
had a shorter duration of mechanical ventilation and length of ICU stay, and
lower relative risk (RR) of pulmonary morbidity (RR, 0.81; 95% confidence
interval [CI], 0.60 - 1.1) and of multiple organ failure (RR, 0.43; 95% CI,
0.19 - 0.96)"
-
HRT, Vitamins C &
E Don't Help Heart - WebMD, 11/19/02 - "New
research offers still more evidence that hormone replacement therapy does
more harm that good in older women with heart disease, and it also raises
doubts about the safety of the antioxidant vitamins E and C"
-
How many international units of vitamin E are in the Gamma E
Tocopherol/Tocotrienol product? - Life Extension Magazine, 11/02 -
"The only form of vitamin E that has a standard
conversion formula from milligrams to international units is alpha
tocopherol. The other forms of vitamin E, beta, gamma and delta, do not have
a conversion formula and are therefore listed in milligrams on the bottle
... The point to remember is to make sure that your daily total intake of
vitamin E contains at least 20% gamma tocopherol. A study in Proceedings of
the National Academy of Sciences (April 1997) suggests that it could be
dangerous to take high doses of alpha tocopherol without also consuming
gamma tocopherol"
-
Dietary Intake Of Vitamin E May Reduce Risk Of Parkinson's Disease
- Intelihealth, 10/22/02 - maybe the reason supplements didn't work is
because most supplements only have the alpha form, which has been shown to
lower the gamma.
-
Antioxidants May Reduce Alzheimer's Disease Risk - Clinical Psychiatry
News, 10/02 - "Use of vitamins E and
C together—which is what most subjects did—was
associated with an eightfold reduction in prevalence and a fivefold lower
incidence of Alzheimer's disease"
-
More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical
Psychiatry News, 10/02 - "Data are now strong enough
to recommend a dietary strategy for reducing
Alzheimer's disease (AD) risk that includes low fat intake and high
consumption of
fish and antioxidants, along with
vitamin E,
folic acid, and
vitamins B6 and B12 supplements"
-
Newly Discovered Benefits of Gamma Tocopherol - Life Extension Magazine,
10/02 - "Since taking large doses of alpha
tocopherol depletes plasma levels of gamma tocopherol, the
health-conscious consumer who takes only alpha tocopherol supplements needs
to seriously reconsider this practice ... Likewise, most vitamin E
supplements provide only alpha tocopherol. New evidence strongly suggests
that this is inadequate supplementation ... men with the highest plasma
levels of gamma tocopherol (the top quintile) had only one-fifth the risk of
prostate cancer compared with the men with the lowest plasma levels"
- I still feel that taking only the alpha can do more harm than good.
Here's the referenced Am J Clin Nutr abstract:
-
gamma-tocopherol, the major form of vitamin E in the US diet, deserves
more attention - Am J Clin Nutr 2001 Dec;74(6):714-22 -
"Both gamma-tocopherol and gamma-CEHC, but not
alpha-tocopherol, inhibit cyclooxygenase activity and, thus, possess
antiinflammatory properties. Some human and animal studies indicate that
plasma concentrations of gamma-tocopherol are inversely associated with
the incidence of cardiovascular disease and prostate cancer. These
distinguishing features of gamma-tocopherol and its metabolite suggest
that gamma-tocopherol may contribute significantly to human health in
ways not recognized previously. This possibility should be further
evaluated, especially considering that high doses of alpha-tocopherol
deplete plasma and tissue gamma-tocopherol, in contrast with
supplementation with gamma-tocopherol, which increases both"
-
Vitamins C And E Support Breathing Following An Operation
- Intelihealth, 9/12/02 -
"Patients who have recently undergone an operation
experience less breathing problems after being given a cocktail of
vitamins C and E"
-
Vitamin E Is Important For Early Prevention Of Cardiovascular Disease In
Middle-Aged Women - Intelihealth, 8/23/02 -
"Low intakes of vitamin E were significantly
associated with plaques in the carotid bifurcations, which are the sites
where most early atherosclerosis begins. Women with the lowest intakes and
plasma concentrations of vitamin E were more than twice as likely to have
this type of plaque"
-
Natural Remedies for
Osteoarthritis: Now, More than Ever - New Hope Natural Media, 8/15/02 -
"Other natural substances that have been reported to
relieve the symptoms of OA include vitamin E (600 to 1,200 IU per day),
Devil's claw,
cat's claw and ginger root"
-
A Better Anti-Oxidant
Formula? - Dr. Weil, 8/13/02
-
High Dose Vitamin E Appears to Reduce Alzheimer's Risk
- Doctor's Guide, 7/24/02 -
"An analysis of data from the Baltimore Longitudinal
Study of Aging suggests that vitamin E intake is associated with a
statistically significant reduction in the risk of
Alzheimer's disease
(AD) ... People with the highest quartile of vitamin E intake, 46.5 mg, had
a 26 percent reduction in risk for developing AD."
-
Vitamin E an Effective
Treatment for Eczema - New Hope Natural Media, 7/11/02
-
Negative Results in
Antioxidant-Heart Study Challenged: A Healthnotes Newswire Opinion - New
Hope Natural Media, 7/11/02 - "Nutrients work in the
body as a team, and all of them must be present in adequate amounts in order
to promote good health. If magnesium, for example, were the weakest link in
the nutritional chain, one would not expect antioxidants to do much good
until the magnesium deficiency was corrected ... Rather than testing only
one or a few nutrients at a time, researchers should use a supplement that
contains all of the nutrients known to promote heart health" - Some
of my concerns: All the vitamin E studies I've read have only used the
alpha tocopherol and taking only the alpha has been shown to
significantly lower the gamma tocopherol. I also feel that the studies
using only beta carotene are pointless. Beta carotene is just one of over
600 carotenoids and many researchers believe that taking mega doses of just
one carotenoid can cause of deficiency of the others.
-
Link Found Between Vitamin E Intake and Immunoglobulin E In Treatment Of
Atopic Dermatitis - Doctor's Guide, 5/31/02 -
"Dietary vitamin E (VE) could be an excellent tool
in treating
atopic dermatitis"
-
Lipoprotein Alterations Impair Vitamin E In Patients With Parenchymal Liver
Cirrhosis - Doctor's Guide, 5/21/02 -
"Significant increases were seen in the plasma
maximal oxidation rate in
cirrhotic patients, which was inversely related to the serum
concentration of vitamin E"
-
What's Wrong With Vitamin E? - Life Extension Magazine, 5/02 -
"Most vitamin E supplements consist primarily of
alpha tocopherol. Recent studies indicate that a lot more than alpha
tocopherol is needed to protect against degenerative disease ... To obtain
optimal health benefits from vitamin E, a mixture of tocopherols (alpha,
beta, delta, and gamma) and tocotrienols (alpha, beta, delta, and gamma) are
required ...In an animal model of aging, tocotrienols extended lifespan by
19% ... studies indicate that high dose alpha-tocopherol supplementation
considerably decreases the absorption of gamma-tocopherol and reduces the
effects of tocotrienols"
-
Does Vitamin E Prevent Breast Cancer? - Life Extension Magazine, 5/02 -
"premenopausal women with a family history who
consumed the highest quantity of vitamin E enjoyed a 43% reduction in
breast cancer incidence compared to only a 16%
risk reduction for women without a family history of breast cancer.[11]
Based on this study, vitamin E appears to protect against genetic-
predisposed breast cancer better than environmental-induced breast cancer.
(Note that nutrients like
indole-3-carbinol may specifically protect against
environmental breast carcinogens.)"
-
Vitamins Help After Heart Transplant - WebMD, 3/28/02 -
"The plaque-fighting benefits of the
antioxidant supplements were even greater than those found using statin
medications, which have already been shown to slow hardening of the arteries
after transplants. Previous research has shown that antioxidants, such as
vitamin C and E, can promote heart health
by reducing blood clots and keeping the blood vessels flexible"
-
Few
Vitamins Effectively Prevent or Reverse Skin Damage
- Medscape, 3/02 - "New laboratory studies suggest
vitamin E helps inactivate free radicals, making them less likely to cause
damage"
-
Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's
Guide, 11/14/01 -
"increasing levels of serum
beta- carotene
were associated with significant reductions in systolic
blood pressure, while increasing levels of serum
vitamin C were associated with significant reductions in diastolic
pressure ... In contrast, serum levels of vitamin E were associated with
significant increases in diastolic blood pressure"
-
Everbody's Getting Alzheimer's, Decline Can Happen Fast in Those Over 65
- WebMD, 11/12/01 - "We know that dementia is
extremely common, especially as we age ... He recommends 800IU twice a day
for people who are already have dementia; for older people at risk, 400IU
twice a day. Younger people and people at low risk are advised to take 400
IU once a day"
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the
rich and famous, Oz Garcia is singing the praises of the Life Extension
Foundation and its products in his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene, gamma
tocopherol, vinpocetine, SAMe,
folic acid, carnosine,
glutathione, DMAE, Huperzine A,
probiotics, MSM,
secretagogues,
arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
-
Vitamin E Prevents - Nutrition Science News, 11/01
-
Zinc,
Antioxidants Prevent Some Forms of Vision Loss
- WebMD, 10/12/01 - "people at risk of losing more
sight due to a condition called "age-related macular degeneration" (AMD)
could prevent further vision loss by taking a combination of zinc and
antioxidants, including vitamins C and E and beta-carotene ... The
antioxidants were taken once a day at a dose of 500 mg of vitamin C, 400 IU
of vitamin E, and 15 mg of beta-carotene. Zinc was given as 80 mg of zinc
oxide along with 2 mg of copper in the form of cupric oxide to prevent
anemia, which can occur from too much zinc ... the high levels of dietary
supplements that were taken in this study are very difficult to achieve from
diet alone"
-
A Prescription for Alarm - Nutrition Science News, 9/01 -
"Taking natural vitamin E supplements to reduce
levels of C-reactive protein, an inflammatory compound that increases the
risk of heart disease by 4.5 times. Heart disease is increasingly viewed as
a disease of blood-vessel inflammation"
-
Antioxidants Resolve Radiation Side Effects - Nutrition Science News,
9/01
-
Could Nicotinamide And
Vitamin E Have Synergistic Effect And Reduce Insulin Usage?
- Doctor's Guide, 7/11/01 - "The combination of
nicotinamide and vitamin E might have a synergistic effect in lowering daily
insulin usage among newly diagnosed Type 1 diabetics"
-
Vitamin E May Help Prevent Menopause Bone Loss - WebMD, 6/28/01 -
"Treating these rats with vitamin E at a dose
comparable to 400 IU in humans was just as good as estrogen treatment in
restoring bone density and weight"
-
Newer Agents Offer Better Hot Flash Control In Breast Cancer Patients -
Doctor's Guide, 4/4/01 - "If hot flashes are mild
and/or the patient is risk averse, vitamin E (800 IU/day) is reasonable to
try, because it is safe, inexpensive, and has some demonstrated efficacy"
-
The Prediabetic Epidemic - Nutrition Science News, 3/01 -
"Supplements to Regulate Glucose and Insulin ...
Alpha-Lipoic Acid ... Vitamin E ... A British study of 2,000 subjects
with carefully diagnosed heart disease found that people taking 400800 IU
natural vitamin E daily for an average of 18 months had a 77 percent lower
prevalence of heart attacks, compared with people taking placebos ...
Vitamin C ...
Chromium ...
Silymarin" - (I assume that the natural form includes gamma
tocopheryls whereas most US studies I have read use only the alpha, which
has been shown to lower gamma. That's why I feel there is conflicting
studies with vitamin E. - Ben)
-
Vitamin E 2000 - Nutrition Science News, 3/01
-
High-Dose Vitamin E May Help Hearts - WebMD, 3/1/01 -
"Rimm led a study of vitamin E supplements (100
IU/day) in 38,884 men aged 40-75 without heart disease. Those who received
vitamin E had a 25% reduction in risk of heart disease."
-
Vitamin E May Prevent
Prostate Cancer
- Doctor's Guide, 3/18/98 -
"long-term use of a moderate-dose vitamin E
supplement substantially reduced prostate cancer incidence and deaths in
male smokers"
-
Military Program Proposes
Saving Money Through Vitamin Supplementation
- Doctor's Guide, 5/22/97 - "A new report by the
National Defense Council Foundation finds that the federal government could
save up to $6.3 billion annually by increasing the health of active and
retired military personnel through a anti-aging program that includes the
use of vitamin supplementation"
Abstracts:
-
Effect of vitamin E intake
on glycemic control and insulin resistance in diabetic patients: an updated
systematic review and meta-analysis of randomized controlled trials - Nutr J
2023 Feb 17 - "This indicates a significant lowering
effect of vitamin E on HbA1c, fasting insulin and HOMA-IR, while no significant
effect on fasting blood glucose in diabetic patients. However, in subgroup
analyses, we found that vitamin E intake significantly reduced fasting blood
glucose in studies with an intervention duration of < 10 weeks. In conclusion,
vitamin E intake has a beneficial role in improving HbA1c and insulin resistance
in a population with diabetes. Moreover, short-term interventions with vitamin E
have resulted in lower fasting blood glucose in these patients" - See
vitamin E at Amazon.com.
-
Tocovid Attenuated Oxidative
Stress and Cognitive Decline by Inhibiting Amyloid-β-Induced NOX2 Activation in
Alzheimer's Disease Mice - J Alzheimers Dis 2022 Dec 22 -
"NADPH oxidase 2 (NOX2) is an important source of
reactive oxygen species (ROS). Activated NOX2 may contribute to Alzheimer's
disease (AD). Our previous studies showed that a novel vitamin E mixture,
Tocovid, had potential neuroprotective effects in a stroke mice model and an AD
cell model ... These findings suggest that NOX2 is a potential target in AD
pathology. Long-term administration of Tocovid may be a promising candidate for
AD treatment" - See Tocovid at
Amazon.com.
-
On the Potential Role of the
Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair
Health - Antioxidants (Basel) 2022 Nov 17 - "The
relationship between oxidative stress and skin aging/disorders is well
established. Many topical and oral antioxidants (vitamins C and E, carotenoids,
polyphenols) have been proposed to protect the skin against the deleterious
effect induced by increased reactive oxygen species production, particularly in
the context of sun exposure. In this review, we focused on the combination of
vitamin E and selenium taken in supplements since both molecules act in synergy
either by non-enzymatic and enzymatic pathways to eliminate skin lipids
peroxides, which are strongly implicated in skin and hair disorders." -
See vitamin E at Amazon.com and
se-methyl l-selenocysteine at Amazon.com.
-
Supplementation With
Carotenoids, Omega-3 Fatty Acids, and Vitamin E Has a Positive Effect on the
Symptoms and Progression of Alzheimer's Disease - J Alzheimers Dis 2022 Sep
9 - "Following 12 months of supplementation, the active
group (n = 50) compared to the placebo group (n = 27), demonstrated
statistically significant improvements in skin carotenoid measurements, blood
carotenoids, ω-3FAs, and vitamin E concentrations (p < 0.05, for all). The
active group also performed better in objective measures of AD severity (i.e.,
memory and mood), with a statistically significant difference reported in the
clinical collateral for memory" - See mixed carotenoids at Amazon.com,
omega-3 supplements at Amazon.com and
vitamin E at Amazon.com.
-
Effect of vitamin E
supplementation in rheumatoid arthritis: a systematic review and meta-analysis
- Eur J Clin Nutr 2022 Apr 25 - "Vitamin E's ability to
restore the intestinal barrier and improve the gastrointestinal tract may be
linked to the prevention and treatment of rheumatoid arthritis. Vitamin E
supplements used on a regular basis can help individuals with RA reduce joint
discomfort, edema, and stiffness, as well as enhance their overall quality of
life"
-
δ-Tocotrienol is the most
potent vitamin E form in inhibiting prostate cancer cell growth and inhibits
prostate carcinogenesis in Ptenp-/- mice - Cancer Prev Res (Phila) 2022 Feb
10 - "Vitamin E compounds, consisting of α, β, γ, and δ
forms of tocopherols and tocotrienols, display different cancer preventive
activities in experimental models. Tocotrienols may have higher potential for
clinical use due to their lower effective doses in laboratory studies ... We
found that δ-tocotrienol (δT3) was the most effective form in inhibiting cell
growth at equivalent doses. Because of this in vitro potency, δT3 was further
studied using prostate specific Pten-/- (Ptenp-/-) mice. We found that 0.05% δT3
in diet reduced prostate adenocarcinoma multiplicity by 32.7%, featuring
increased apoptosis and reduced cell proliferation. The inhibitory effect of
0.05% δT3 in diet was similar to that of 0.2% δ-tocopherol (δT) in diet reported
previously. Our further study on the δT3-induced transcriptome changes indicated
that δT3 inhibited genes in blood vessel development in the prostate of Ptenp-/-
mice, which was confirmed by immunohistochemistry. Together, our results
demonstrate that δT3 effectively inhibits the development of prostate
adenocarcinoma in Ptenp-/- mice, which involves inhibition of proliferation and
angiogenesis and promotion of apoptosis" - See
delta vitamin E at Amazon.com.
-
Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working
memory in older adults: A randomised clinical trial - Clin Nutri, 12/6/21 -
"Cognitively healthy individuals aged ≥65 years consumed
daily 1 g fish oil (of which 430 mg docosahexaenoic acid, 90 mg eicosapentaenoic
acid), 22 mg carotenoids (10 mg lutein, 10 mg meso-zeaxanthin, 2 mg zeaxanthin)
and 15 mg vitamin E or placebo for 24 months in a double-blind,
placebo-controlled, randomised clinical trial ... Following 24-month
supplementation, individuals in the active group (n = 30; aged 69.03 ±
4.41years; 56.7% female) recorded significantly fewer errors in working memory
tasks than individuals receiving placebo (n = 30; aged 69.77 ± 3.74 years; 70%
female) ... These results support a biologically plausible rationale whereby
these nutrients work synergistically, and in a dose-dependent manner, to improve
working memory in cognitively healthy older adults. Increasing nutritional
intake of carotenoids and ω-3FAs may prove beneficial in reducing cognitive
decline and dementia risk in later life" - [Nutra
USA] - See docosahexaenoic acid at Amazon.com,
mixed carotenoids at Amazon.com, and
vitamin E at Amazon.com.
-
γ-Tocotrienol induced the
proliferation and differentiation of MC3T3-E1 cells through the stimulation of
the Wnt/β-catenin signaling pathway - Food Funct 2021 Dec 15 -
"γ-Tocotrienol (γ-T3), an isoprenoid phytochemical, has
shown the promotion of osteoblast proliferation and differentiation in our
previous study ... Therefore, γ-T3 may be a potential agent to prevent and
reverse osteoporosis due to its safety and powerful abilities of osteogenesis"
- See gamma-tocotrienol at Amazon.com.
-
Association Between Serum
Vitamins and the Risk of Alzheimer's Disease in Chinese Population - J
Alzheimers Dis 2021 Dec 2 - "We conclude that lower
vitamin B2, B9, B12, D, and E might be associated with the risk of AD,
especially vitamin B2, B9, and B12. And lower vitamin E might be related to
severe ability impairment of daily activities" - See
B complex supplements at Amazon.com,
vitamin D at Amazon.com and
vitamin E at Amazon.com.
-
The effects of
co-administration of artichoke leaf extract supplementation with metformin and
vitamin E in patients with nonalcoholic fatty liver disease: A randomized
clinical trial - Phytother Res 2021 Sep 17 -
"Medicinal plants are widely used as a complementary therapy to treat complex
diseases, such as nonalcoholic fatty liver disease (NAFLD). Therefore, this
study was done to investigate the effect of co-administration of artichoke leaf
extract supplement (ALES) with conventional medicines on patients with NAFLD ...
In summary, the results of the present study showed that the concomitant use of
ALES with metformin and vitamin E can have beneficial effects on amelioration of
complications in patients with NAFLD" - See
artichoke extract at Amazon.com,
vitamin E at Amazon.com
and
iHerb and
metformin at ReliableRX.
-
Quercetin and vitamin E
attenuate diabetes-induced testicular anomaly in Wistar rats via the
mitochondrial-mediated apoptotic pathway - Andrologia 2021 Jul 18 -
"The role of quercetin and vitamin E treatment against
streptozotocin (STZ)-induced testicular abnormalities in diabetic rats and the
possible mechanism of action they use for protection were investigated ... The
study showed a positive correlation in the levels of LH, FSH and testosterone;
it was further established that all treatments normalised diabetes-induced
alterations. Treatment with quercetin and vitamin E resulted in 34% decrease of
apoptogenic cytochrome c release. This protected the testes against excessive
apoptosis by decreasing caspase 3 and caspase 9 activation by up to 30 and 28%
respectively (p < .05). Histology also showed that treatment prevented
testicular cell death. The findings show that quercetin/vitamin E possess free
radical scavenging properties that protected against testicular damage in
diabetes. This suggests the possibility of pharmaco-therapeutic intervention"
- See quercetin at Amazon.com and
iHerb and
Vitamin E at Amazon.com
and
iHerb.
-
Alpha-Tocopherol Protects
Human Dermal Fibroblasts by Modulating Nitric Oxide Release, Mitochondrial
Function, Redox Status, and Inflammation - Skin Pharmacol Physiol 2021 Jul 8
- "human dermal fibroblasts (HDF) ... α-Tocopherol
exerts protective effects in HDF which underwent oxidative stress by modulating
the redox status, inflammation, iNOS-dependent NO release, and mitochondrial
function. These observations have a potential role in the prevention and
treatment of photoaging-related skin cancers" - See
vitamin E at Amazon.com
and
iHerb.
-
Protective role of vitamin E
in testicular development of mice exposed to valproic acid - Andrologia 2021
Jun 21 - "Valproic acid (VPA) is a teratogenic
antiepileptic, causing alterations in oxidative stress in prenatal development,
being altered the development of the male reproductive system. The purpose of
this study was to determine the protective effect of vitamin E (VE) on the
testicular development in embryos, foetuses and pubertal mice exposed to VPA,
VPA+VE and only VE ... VE reduces the effects caused by VPA throughout
testicular development, from embryonic stages, continuing until pubertal stages"
- See vitamin E at Amazon.com
and
iHerb.
-
Protective Effects of
Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of
Randomized Controlled Trials - Ann Nutr Metab 2021 Jun 18 -
"Chemotherapy-induced peripheral neuropathy (CIPN) is a
common symptom, but prophylactic measures cannot still be carried out
effectively ... Available data in this meta-analysis showed that vitamin E
supplementation can confer modest improvement in the prevention of CIPN"
-
Association of measures of
body fat with serum alpha-tocopherol and its metabolites in middle-aged
individuals - Nutr Metab Cardiovasc Dis 2021 May 18 -
"The accumulation of fat increases the formation of
lipid peroxides, which are partly scavenged by alpha-tocopherol (α-TOH) ...
Opposite to our research hypothesis, higher abdominal adiposity was moderately
associated with lower levels of oxidized α-TOH metabolites, which might reflect
lower vitamin E antioxidative activity in individuals with higher abdominal fat
instead"
-
Effects of delta-tocotrienol
supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers
and miRNA expression in type 2 diabetes mellitus: A randomized control trial
- Phytother Res 2021 Apr 25 - "Compared to the placebo,
δT3 supplementation resulted in a significant (p ≤ .05) reduction [mean
difference (95% confidence interval)] in plasma glucose [-0.48 (-0.65, -0.30)],
insulin [-1.19 (-1.51, -0.87)], homeostatic model assessment of insulin
resistance [-0.67 (-0.86, -0.49)], glycosylated hemoglobin [-0.53 (-0.79,
-0.28)], malondialdehyde [-0.34 (-0.45, -0.22)], high sensitive-C-reactive
protein[-0.35 (-0.54, -0.16)], tumor necrosis factor-alpha [-1.22 (-1.62,
-0.83)], and interleukin-6[-2.30 (-2.91, -1.68)]. More than twofold
downregulation in miRNA-375, miRNA-34a, miRNA-21, and upregulation in miRNA-126,
miRNA-132 expression was observed in the δT3 group compared to the placebo. The
study demonstrated that δT3 supplementation in addition to oral hypoglycemic
agents, improved glycemic control, inflammation, oxidative stress, and miRNA
expression in T2DM without any adverse effect. Thus, δT3 might be considered as
an effective dietary supplement to prevent long-term diabetic complications"
-
The Effects of Vitamin E,
Silymarin and Carnitine on the Metabolic Abnormalities Associated with
Nonalcoholic Liver Disease - J Diet Suppl 2021 Jan 25 -
"Studies indicate that antioxidant supplementation may
improve abnormal liver chemistries, glucose control, and hyperlipidemia, in
patients with nonalcoholic fatty liver disease (NAFLD). The primary objective of
the study was to determine the normalization of abnormalities in hepatic
function testing in patients with NAFLD when treated with vitamin E 200 IU,
Silymarin 750 mg, and l-carnitine 1 gram (VSC) for 18 weeks in comparison to a
placebo-controlled group ... VSC caused a significant reduction in serum
glucose, insulin, and HOMA levels. While there were downtrends in the other
measured values these were not statistically significant. In this 18-week study,
the ability of this supplement in reducing markers of liver inflammation,
glucose, insulin, and triglycerides indicate that this supplement could play an
important role in the treatment of nonalcoholic fatty liver disease, diabetes,
and the metabolic syndrome" - See
Jarrow FamilE (contains all eight members
of the vitamin E family, includes Tocomin) at Amazon.com,
silymarin at Amazon.com and L-carnitine at Amazon.com.
-
Vitamin E for the management
of major depressive disorder: possible role of the anti-inflammatory and
antioxidant systems - Nutr Neurosci 2020 Dec 14 -
"Vitamin E has various functions in humans, including antioxidant,
anti-inflammatory, anti-cancer, and anti-atherogenic actions, as well as direct
effects on enzymatic activities and modulation of gene transcription. In
addition to these functions, vitamin E is also important for the central nervous
system, and its role in the prevention and/or treatment of some neurological
diseases has been suggested. In particular, the role of vitamin E in the
modulation of major depressive disorder (MDD) is an issue that has emerged in
recent studies. Many factors have been implicated in the pathophysiology of this
disorder, including inflammation, oxidative, and nitrosative stress ... We
gathered evidence from clinical studies that demonstrated the relationship
between low vitamin E status and MDD symptoms. Vitamin E has been reported to
exert a beneficial influence on the oxidative and inflammatory status of
individuals, factors that may account for the attenuation of depressive
symptoms. Preclinical studies have reinforced the antidepressant-like response
of vitamin E, and the mechanisms underlying its effect seem to be related to the
modulation of oxidative stress and neuroinflammation"
-
Association of Antioxidant
Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort
Study of Middle-Aged Adults - Nutrients 2020, 12(11), 3558 -
"Carotenoids may strengthen the association of
antioxidant vitamins A, C, and E with favorable cognitive outcomes over time,
though a few prospective studies have examined this hypothesis ... Mixed-effects
linear regression models detected an interaction between vitamin E and total
(and individual) carotenoids for three of 11 cognitive tests at v1, with only
one meeting the statistical significance upon multiple testing correction
whereby vitamin E was linked with greater verbal memory performance in the
uppermost total carotenoid tertile (γ0a = +0.26 ± 0.08, p = 0.002), a synergism
largely driven by carotenoid lycopene. Vitamins A and C showed no consistent
interactions with carotenoids. In conclusion, we provide partial evidence for
synergism between vitamin E and carotenoids in relation to better baseline
cognitive performance, pending further studies with time-dependent exposures and
randomized trials directly examining this synergism" - [Nutra
USA] - See mixed carotenoids at Amazon.com
and
Jarrow FamilE (contains all eight members
of the vitamin E family, includes Tocomin) at Amazon.com and
iHerb.
-
Supplementation with
Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a
Cluster of Older Adults with Metabolic Syndrome - Nutrients 2020 Oct 15 -
"In order to assess the effect of a dietary supplement
on chronic inflammation in MetS, we conducted a clinical trial with volunteers
receiving a formula composed of resveratrol, piperine and alpha tocopherol
(FRAMINTROL®), together with their habitual treatment, for three months ... The
results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p <
0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous
chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know,
this is the first study showing a chronic inflammation decrease in MetS patients
due to the administration of a biopower Resveratrol-piperine and alpha
tocopherol dietary supplement together with conventional therapy" -
See resveratrol products at Amazon.com and
resveratrol at iHerb, piperine extract at
Amazon.com and
iHerb and vitamin E at Amazon.com
and
iHerb.
-
Dietary Vitamin E Intake Was
Inversely Associated with Hyperuricemia in US Adults: NHANES 2009-2014 - Ann
Nutr Metab 2020 Sep 21 - "After adjustment for age,
gender, BMI, race, educational level, smoking status, alcohol consumption,
physical activity, total daily energy intake, total cholesterol, protein intake,
glomerular filtration rate, serum Cr, use of uric acid drugs, and drug abuse,
the odds ratio (95% confidence interval) of hyperuricemia for the highest
tertile of dietary vitamin E intake was 0.77 (0.63-0.96) compared with that of
the lowest tertile. In men, dietary vitamin E intake and hyperuricemia were
negatively correlated. In stratified analyses by age (20-39, 40-59, and ≥60
years), dietary vitamin E intake was inversely associated with hyperuricemia
only among participants aged ≥60 years. Dose-response analyses showed that
dietary vitamin E intake was inversely associated with hyperuricemia in a
nonlinear manner"
-
Delta-tocotrienol supplementation improves biochemical markers of hepatocellular
injury and steatosis in patients with nonalcoholic fatty liver disease: A
randomized, placebo-controlled trial - Complementary Therapies in Medicine,
Aug 2020 - "patients with NAFLD were randomly assigned
to receive δ-tocotrienol 300 mg twice daily or placebo for 24 weeks ...
δ-tocotrienol effectively improved biochemical markers of hepatocellular injury
and steatosis in patients with NAFLD. δ-tocotrienol supplementation might be
considered as a therapeutic option in the management of patients with NAFLD"
- [Nutra
USA] - See delta-tocotrienol at Amazon.com
and
iHerb.
-
Supplementation with SEPIFIT TM Protect, a complex of a natural red wine
extract, vitamin E and zinc, improves exercise recovery in healthy men -
Nutrafoods (2020) 1:149-158 - "Muscle fatigue can be largely reversible in
minutes or hours. It is generally viewed to be the result of insufficient energy
and a lack of availability of key metabolites that enable contracting muscles to
meet increased energy demand. However, muscle recovery can fail to take effect
quickly, and this can be associated with structural changes and damage within
the muscle, inducing a cascade of events leading to immediate or delayed
soreness. In previous research, SEPIFIT TM Protect, a combination of natural red
wine polyphenols, zinc and vitamin E, showed in vitro efficacy with respect to
lactate, interleukin-6 and creatine kinase, which are markers of muscle damage
and fatigue. We have therefore conducted a pilot clinical study to evaluate the
effects of this active complex in healthy men undertaking regular and stable
physical activity and who were subjected to a pain induction protocol. The
results showed that the consumption of 135 mg of the complex per day for 12 days
was effective in reducing creatine kinase release and maintaining muscular power
capacity after the pain induction protocol. It also induced a better perception
of performance, physical condition and muscle soreness. SEPIFIT TM Protect can
thus be considered an interesting complex to contribute to muscle recovery
during physical exertion" - [Nutra
USA] - See resveratrol products at Amazon.com and
resveratrol at iHerb, vitamin E at
Amazon.com
and
iHerb and zinc supplements at
Amazon.com and
iHerb.
-
Tocotrienol-rich vitamin E
improves diabetic nephropathy and persists 6-9 months after washout: a phase IIa
randomized controlled trial - Ther Adv Endocrinol Metab. 2019 Dec 25 -
"receive Tocovid 200 mg or placebo for 12 weeks ...
Patients were reassessed 6-9 months post-washout. After 12 weeks of
supplementation, Tocovid significantly decreased serum creatinine levels (mean
difference: -3.3 ± 12.6 versus 5.4 ± 14.2, p = 0.027) and significantly increase
eGFR (mean difference: 1.5 ± 7.6 versus -2.9 ± 8.0, p = 0.045) compared with
placebo ... Subgroup analysis revealed that in patients with low serum vitamin E
concentrations at baseline, Tocovid reduced serum creatinine, eGFR, and VCAM-1
significantly. After 6-9 months of washout, persistent difference in serum
creatinine remained between groups (mean difference: 0.82 ± 8.33 versus
11.26 ± 15.47, p = 0.031), but not eGFR. Tocovid at 400 mg/day significantly
improved renal function in 12 weeks of supplementation, as assessed by serum
creatinine and eGFR, which remained significant 6-9 months post-washout"
- [Nutra
USA] - See Tocovid at Amazon.com.
-
The effect of omega-3 and
vitamin E on oxidative stress and inflammation: Systematic review and
meta-analysis of randomized controlled trials - Int J Vitam Nutr Res. 2019
Aug 23:1-1 - "The present meta-analysis found that
omega-3 fatty acids and vitamin E co-supplementation significantly decreased
hs-CRP and increased NO and TAC" - See
omega-3 supplements at Amazon.com and
vitamin E products at Amazon.com.
-
Effect of
annatto-extracted tocotrienols and green tea polyphenols on glucose homeostasis
and skeletal muscle metabolism in obese male mice - J Nutr Biochem. 2019 Feb
10;67:36-43 - "This study evaluated the effects of
tocotrienols (TT) and green tea polyphenols (GTP) individually or in combination
on glucose homeostasis and skeletal muscle metabolism in obese mice with insulin
resistance and elevation of blood glucose ... Both GTP and TT improved area
under curve of insulin intolerance; while GTP increased serum insulin levels in
obese mice, probably due to the addition of sweetener in drinking water. An
interaction (TT×GTP) was observed in glucose tolerance test, total pancreas
insulin concentration, and citrate synthase activity of soleus in mice ... Both
TT and GTP individually increased soleus muscle weight of mice; while only GTP
increased gastrocnemius muscle weight of mice. The TT+GTP group had the greatest
gastrocnemius muscle cross sectional area than other groups" - [Nutra
USA] - See
vitamin E products at Amazon.com
and
green tea extract at Amazon.com.
-
Effect of vitamin E
supplementation on blood pressure: a systematic review and meta-analysis - J
Hum Hypertens. 2019 Mar 7 - "Results of this study
showed that compared to placebo, SBP decreased significantly in vitamin E group
(WMD = -3.4 mmHg, 95% CI = -6.7 to -0.11, P < 0.001), with a high heterogeneity
across the studies (I2 = 94.0%, P < 0.001). Overall, there were no significant
effects on DBP and MAP" - Yeah, but isn't systolic and pulse
pressure the main problem as people age?
-
Tocotrienol-Rich Vitamin
E from Palm Oil (Tocovid) and Its Effects in Diabetes and Diabetic Nephropathy:
A Pilot Phase II Clinical Trial - Nutrients. 2018 Sep 17 -
"Tocotrienol-rich vitamin E from palm oil (Tocovid) has
been shown to ameliorate diabetes through its superior antioxidant,
antihyperglycemic, and anti-inflammatory properties in diabetic rats ... Nε-Carboxymethyllysine
(Nε-CML) ... The intervention group (n = 22) received Tocovid 200 mg twice a day
while the control group (n = 23) received placebo twice a day for 8 weeks.
Changes in Hemoglobin A1c (HbA1c), blood pressure, serum biomarkers and renal
parameters such as UACR, serum creatinine, and estimated Glomerular Filtration
Rate (eGFR) were compared between the two groups. It was found that serum Nε-CML
significantly correlated to the severity of microalbuminuria. For every 1 ng/mL
increase in serum Nε-CML, the odds of diabetic nephropathy increased by 1.476
times. Tocovid, compared to placebo, significantly reduced serum creatinine but
not eGFR, UACR, HbA1c, blood pressure, and serum biomarkers. In conclusion,
serum Nε-CML is a potential biomarker for diabetic nephropathy. Treatment with
Tocovid significantly reduced serum creatinine; therefore Tocovid may be a
useful addition to the current treatment for diabetic nephropathy" - [Nutra
USA] - See Tocovid at Amazon.com.
-
L-Ascorbic Acid and α-Tocopherol
Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by
Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells - Nutr
Cancer. 2018 Apr 26:1-13 - "Arsenic trioxide (As2O3) is a promising new regimen
for the treatment of acute promyelocytic leukemia (APL). The induction of
oxidative stress mediated by reactive oxygen species (ROS) and excessive
intracellular calcium influx are the main reasons behind As2O3 toxicity ...
Cotreatment of antioxidant vitamins with As2O3 resulted in a significant
reversal of oxidative stress markers. Our findings substantiate the effect of
antioxidant vitamins in protecting the hepatocytes from oxidative stress which
may be attributed through Nrf2 (Nuclear factor erythroid 2-related factor 2)
mediated upregulation of Bcl2 (B-cell lymphoma 2) expression" - See
vitamin C products at Amazon.com
and
vitamin E products at Amazon.com.
-
Association of
Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease -
Nutrients. 2018 Jan 27;10(2) - "Since vitamin E exerts
important anti-oxidative functions, we hypothesized that circulating vitamin E
levels might be inversely associated with prevalence of gallstone disease ...
Lower probabilities of having gallstone disease were observed in the top
(compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in
multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence
Interval): 0.13-0.76). A lower probability of having gallstone disease was also
observed for the γ-tocopherol/cholesterol ratio, though the association did not
reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st
tertile). In conclusion, our observations are consistent with the concept that
higher vitamin E levels might protect from gallstone disease, a premise that
needs to be further addressed in longitudinal studies" - [Nutra
USA] - See
vitamin E products at Amazon.com.
-
Vitamin E improves
testicular damage in streptozocin-induced diabetic rats, via increasing vascular
endothelial growth factor and poly(ADP-ribose) polymerase-1 - Andrologia.
2017 Nov 21 - "Reduced VEGF and PARP-1 immunostaining were associated with
decreased Johnsen score in diabetic rats. Vitamin E administration was
protective against oxidative stress-associated damage evidenced by lower MDA
levels, improved testicular weight, spermatogenesis and higher immunostaining
for VEGF and PARP-1. Testicular VEGF and PARP-1 might therefore be helpful
biomarkers for diabetic testicular damage. Administration of vitamin E may have
a protective role against diabetes-induced testicular damage"
-
Use of Vitamin E and C
Supplements for the Prevention of Cognitive Decline - Ann Pharmacother. 2016
Oct 4 - "Data from the Canadian Study of Health and
Aging (1991-2002), a cohort study of dementia including 3 evaluation waves at
5-yearly intervals, were used ... Compared with those not taking vitamin
supplements, the age-, sex-, and education-adjusted hazard ratios of CIND, AD,
and all-cause dementia were, respectively, 0.77 (95% CI = 0.60-0.98), 0.60 (95%
CI = 0.42-0.86), and 0.62 (95% CI = 0.46-0.83) for those taking vitamin E and/or
C supplements ... This analysis suggests that the use of vitamin E and C
supplements is associated with a reduced risk of cognitive decline"
- [Nutra
USA] - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com
and
American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com
 .
-
Tocotrienols and Whey
Protein Isolates Substantially Increase Exercise Endurance Capacity in Diet
-Induced Obese Male Sprague-Dawley Rats - PLoS One. 2016 Apr
8;11(4):e0152562 - "whey protein isolates (WPIs) and
vitamin E tocotrienols (TCTs) ... Ten weeks of both TCTs and WPIs increased
exercise endurance by 50% in sedentary, diet-induced obese rats" - [Nutra
USA] - See
whey protein at Amazon.com
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Micronutrients and the risk of hip fracture: Case-control study - Clin Nutr.
2015 Dec 23 - "Vitamin D, and possibly vitamin K, has an
established association to fracture risk. Other vitamins are, however, less
studied ... Low vitamin A, C, and E concentrations are associated with an
increased risk of hip fracture, possibly mediated through bone turnover
mechanisms"
-
Positive
Association of Vitamin E Supplementation with Hemoglobin Levels in Mildly Anemic
Healthy Pakistani Adults - Int J Vitam Nutr Res. 2015;85(1-2):39-49 -
"The study showed a positive association between vitamin
E supplementation and enhanced hemoglobin levels in mildly anemic adults"
-
Tocopherols
in cancer: An update - Mol Nutr Food Res. 2016 Jan 11 -
"Large scale clinical trials with α-tocopherol provided
inconsistent results regarding the cancer preventive activities of tocopherols
... The experimental data provide strong evidence in support of the anti-cancer
activities of δ-tocopherol, γ-tocopherol and the natural tocopherol mixture rich
in γ-tocopherol, γ-TmT, over α-tocopherol"
-
Association
of Vitamin E Intake with Reduced Risk of Kidney Cancer: A Meta-Analysis of
Observational Studies - Med Sci Monit. 2015 Nov 8 -
"The pooled RR (95%CI) of kidney cancer for the highest vs. the lowest level of
vitamin E intake was 0.81 ... Results of the present study suggest an inverse
relationship between vitamin E intake and kidney cancer risk"
-
Anticancer
Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- Biol Pharm Bull. 2015 - "γ-Tocotrienol is a natural
isoform within the vitamin E family of compounds that displays potent
antiproliferative and apoptotic activity against a wide range of cancer cell
types at treatment doses that have little or no effect on normal cell viability.
Studies were conducted to determine the effects of γ-tocotrienol on aerobic
glycolysis in mouse +SA and human MCF-7 breast cancer cells. Treatment with
γ-tocotrienol resulted in a dose-responsive inhibition of both +SA and MCF-7
mammary tumor cell growth, and induced a relatively large reduction in glucose
utilization, intracellular ATP production and extracellular lactate excretion.
These effects were also associated with a large decrease in enzyme expression
levels involved in regulating aerobic glycolysis, including hexokinase-II,
phosphofructokinase, pyruvate kinase M2, and lactate dehydrogenase A.
γ-Tocotrienol treatment was also associated with a corresponding reduction in
the levels of phosphorylated (active) Akt, phosphorylated (active) mTOR, and c-Myc,
but not HIF-1α or glucose transporter 1 (GLUT-1). In summary, these findings
demonstrate that the antiproliferative effects of γ-tocotrienol are mediated, at
least in the part, by the concurrent inhibition of Akt/mTOR signaling, c-Myc
expression and aerobic glycolysis"
-
Suboptimal Serum
α-Tocopherol Concentrations Observed among Younger Adults and Those Depending
Exclusively upon Food Sources, NHANES 2003-20061-3 - PLoS One. 2015 Aug 19 -
">90% of American adults are not consuming recommended
amounts of vitamin E ... FOOD consumers have lower average α-tocopherol levels
(24.9± 0.2 μmol/L) than FOOD+DS users (33.7 ± 0.3 μmol/L) ... Using a criterion
of adequacy of 30 μmol/L, 87% of persons 20-30y and 43% of those 51+y had
inadequate vitamin E status ... The prevalence of inadequate vitamin E levels is
significantly higher among non-users of dietary supplements" - [Nutra
USA]
-
Vitamin E has a beneficial
effect on nonalcoholic fatty liver disease: A meta-analysis of randomized
controlled trials - Nutrition. 2015 Jul-Aug;31(7-8):923-30 -
"According to a random effect model analysis of the five
studies, vitamin E significantly reduced aspartate transaminase (AST) by -19.43
U/L, alanine aminotransferase (ALT) by -28.91 U/L, alkaline phosphatase (ALP) by
-10.39 U/L, steatosis by -0.54 U/L, inflammation by -0.20 U/L, and
hepatocellular ballooning by -0.34 U/L compared with the control group. Vitamin
E treatment with NASH adult patients showed obvious reductions in not only AST
of -13.91 U/L, ALT by -22.44 U/L, steatosis of -0.67 U/L, inflammation of -0.20
U/L, but also fibrosis of -0.30 U/L compared to the control treatment" -
[Nutra
USA]
-
Intake of
antioxidants and subsequent decline in physical function in a
racially/ethnically diverse population - J Nutr Health Aging.
2015;19(5):542-7 - "Oxidative stress is considered a
risk factor for physical function (PF) decline with aging ... A low intake
(first quartile) of vitamin E was associated with a greater decline in PF
compared with the highest quartile, with a mean difference in change in PF of
-1.73 (95%CI:-3.31,-0.15). Notably, this mean difference was clinically
meaningful as it was equivalent to the effect estimate we found for participants
who were approximately 15 years apart in age in our cohort, as 1 year increase
in age was associated with a mean difference in change in PF of -0.11
(95%CI:-0.16,-0.06). PF decline was not significantly different in the lowest
compared with the highest quartile of vitamin C (mean difference=-1.29,
95%CI:-2.61, 0.03) or carotenoids (mean difference=-0.62, 95%CI:-2.22,0.99)"
-
Vitamin E
Intake and Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies
- Med Sci Monit. 2015 May 1;21:1249-1255 - "In total, 10
observational studies (6 case-control studies and 4 cohort studies) were
included. The overall RR (95% CI) of pancreatic cancer for the highest vs. the
lowest level of vitamin E intake was 0.81"
-
Pooled
analysis confirms vitamin E as a treatment for non-alcoholic steatohepatitis
- Science Daily, 4/23/15 - "A pooled analysis of data
from two randomised trials comparing vitamin E versus placebo, and the placebo
group from another trial comparing vitamin E use versus non-use, demonstrates
that the efficacy of vitamin E is comparable to other treatments for NASH,
including pioglitazone, metformin and obeticholic acid. In addition, treatment
with vitamin E is associated with significant improvements in both NASH
histology (45% vs 22% in those not treated with vitamin E) and resolution of
disease (38% vs 20% in those not treated with vitamin E)"
-
Supplementation with vitamin E alone is associated with reduced myocardial
infarction: A meta-analysis - Nutr Metab Cardiovasc Dis. 2015 Feb 4 -
"Sixteen randomized controlled trials of vitamin E
treatment were analyzed in this meta-analysis ... Compared to controls, vitamin
E given alone significantly decreased myocardial infarction (3.0% vs 3.4%)
(random effects R.R.: 0.82; 95% C.I., 0.70-0.96; p = 0.01). This effect was
driven by reduction of fatal myocardial infarction (random effects R.R.: 0.84;
95% C.I., 0.73-0.96; p = 0.01)"
-
Vitamin E
and risk of age-related cataract: a meta-analysis - Public Health Nutr. 2015
Jan 16 - "age-related cataract (ARC) ... Dietary vitamin
E intake, dietary and supplemental vitamin E intake, and high serum tocopherol
levels were significantly associated with decreased risk of ARC, the pooled
relative risk was 0.73 (95 % CI 0.58, 0.92), 0.86 (95 % CI 0.75, 0.99) and 0.77
(95 % CI 0.66, 0.91), respectively. Supplemental vitamin E intake was
non-significantly associated with ARC risk (relative risk=0.92; 95 % CI 0.78,
1.07). The findings from dose-response analysis showed evidence of a non-linear
association between dietary vitamin E intake and ARC. The risk of ARC decreased
with dietary vitamin E intake from 7 mg/d (relative risk=0.94; 95 % CI 0.90,
0.97)"
-
Carnosine
and vitamin E - a promising pair in the combat against testicular oxidative
stress in aged rats - Andrologia. 2014 Dec 29 -
"Oxidative stress is considered to play a key role in ageing. Carnosine alone or
together with vitamin E may prove to be helpful in dealing with problems of
ageing through its antioxidant activity. Testis, by producing steroids and
possessing a poor antioxidant system may become a strong target for the chronic
oxidative stress generated during ageing ... Carnosine plus vitamin E treatment
appears to stage a powerful performance by attenuating testicular oxidative
stress and sparing the antioxidant system" - See
carnosine products at Amazon.com
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Potent
inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and
grown as xenograft tumors in vivo - J Agric Food Chem. 2014 Oct 16 -
"the effects of δ-tocopherol (δ-T) on growth and
apoptosis of human prostate cancer cells were determined and compared with that
of α-tocopherol (α-T), a commonly used form of vitamin E. Treatment of human
prostate cancer cells with δ-T resulted in strong growth inhibition and
apoptosis stimulation while the effects of α-T were modest ... In the in vivo
study, we found that δ-T had a more potent inhibitory effect on the formation
and growth of prostate xenograft tumors than α-T. Moreover, δ-T inhibited
proliferation and stimulated apoptosis in the tumors" - Note: α =
alpha, δ = delta.
-
Synergistic
inhibition of cancer cell proliferation with a combination of δ-tocotrienol and
ferulic acid - Biochem Biophys Res Commun. 2014 Oct 3 -
"Rice bran consists
of many functional compounds and thus much attention has been focused on the
health benefits of its components. Here, we investigated the synergistic
inhibitory effects of its components, particularly δ-tocotrienol (δ-T3) and ferulic acid (FA), against the proliferation of an array of cancer cells,
including DU-145 (prostate cancer), MCF-7 (breast cancer), and PANC-1
(pancreatic cancer) cells. The combination of δ-T3 and FA markedly reduced cell
proliferation relative to δ-T3 alone, and FA had no effect when used alone"
- Note: δ is the delta form. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com
and
ferulic acid at Amazon.com.
-
Tocotrienol
Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in
Aged Rats - Lipids. 2014 Jul 12 - "tocotrienol rich
fraction (TRF) ... Aged rats supplemented with TRF showed a markedly reduced
level of anxiety, improved spatial learning and memory, reduced amount and
severity of DNA damage, a reduced level of MDA, and increased levels of
antioxidant enzyme activity and plasma/brain vitamin E compared with age-matched
controls. In conclusion, TRF supplementation reverses spatial learning and
memory decline and decreases oxidative stress in aged rats"
-
Vitamin E
intake and the lung cancer risk among female nonsmokers: A report from the
Shanghai Women's Health Study - Int J Cancer. 2014 Jun 11 -
"In summary, dietary tocopherol intake may reduce the
risk of lung cancer among female non-smokers, however supplements may increase
lung adenocarcinoma risk"
-
The Effects
of α-Tocopherol on Bone: A Double-Edged Sword? - Nutrients. 2014 Apr
10;6(4):1424-1441 - "Recent studies have found
conflicting evidence on the role of α-tocopherol (αTF) on bone health ... Our
review found that αTF exerted beneficial, harmful or null effects on bone
formation cells. Animal studies generally showed positive effects of αTF
supplementation on bone in various models of osteoporosis. However, high-dose
αTF was possibly detrimental to bone in normal animals. Human studies mostly
demonstrated a positive relationship between αTF, as assessed using high
performance liquid chromatography and/or dietary questionnaire, and bone health,
as assessed using bone mineral density and/or fracture incidence. Three possible
reasons high dosage of αTF can be detrimental to bone include its interference
with Vitamin K function on bone, the blocking of the entry of other Vitamin E
isomers beneficial to bone, and the role of αTF as a prooxidant. However, these
adverse effects have not been shown in human studies"
-
Clinical
Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain
White Matter - Stroke. 2014 Apr 3 - "Previous
cell-based and animal studies showed mixed tocotrienols are neuroprotective, but
the effect is yet to be proven in humans. Thus, the present study aimed to
evaluate the protective activity of mixed tocotrienols in humans with white
matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small
vessel disease, reflecting varying degrees of neurodegeneration and tissue
damage with potential as a surrogate end point in clinical trials ... total of
121 volunteers aged ≥35 years with cardiovascular risk factors and MRI-confirmed
WMLs were randomized to receive 200 mg mixed tocotrienols or placebo twice a day
for 2 years ... the mean WML volume of the placebo group increased after 2
years, whereas that of the tocotrienol-supplemented group remained essentially
unchanged"
-
Genetic
Variants Reflecting Higher Vitamin E Status in Men Are Associated with Reduced
Risk of Prostate Cancer - J Nutr. 2014 Mar 12 -
"Findings suggest lower prostate cancer risk for men whose genotypes reflect
higher vitamin E (i.e., α-tocopherol) status. An SNP (rs964184) near
budding-site selection protein 13 [BUD13 (yeast)], zinc finger protein 259
(ZNF259), and apolipoprotein A5 (APOA5) on 11q23.3 was significantly associated
with prostate cancer risk (per-allele OR = 0.75; 95% CI: 0.58, 0.98; P-trend =
0.03). The association between rs964184 and prostate cancer risk was stronger
among homozygous carriers of the minor allele (OR = 0.27; 95% CI: 0.09, 0.83).
Another variant, rs11057830 in scavenger receptor class-B member 1 (SCARB1) on
12p24.31, approached statistical significance (OR = 0.32; 95% CI: 0.10, 1.01, P
= 0.05; 2 minor allele copies)" - Note: Some studies show that
taking only the alpha form of vitamin E can cause a deficiency of the other
forms.
-
Lower
vitamin E serum levels are associated with osteoporosis in early postmenopausal
women: a cross-sectional study - J Bone Miner Metab. 2013 Jul;31(4):455-60 -
"In a multivariate linear model with BMD of the lumbar
spine as a dependent variable, the vitamin E:lipid ratio was clearly related
with BMD of the lumbar spine (F ratio = 6.30, p = 0.002). BMD of the lumbar
spine was significantly higher in the highest tertile of the vitamin E:lipid
ratio than in the lowest tertile ... These findings highlight that vitamin E may
increase BMD in healthy postmenopausal women"
-
Tocotrienols
for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a
randomised placebo-controlled clinical trial - Nutr J. 2013 Dec 27;12(1):166
- "Nonalcoholic fatty liver disease (NAFLD) is one of
the commonest liver disorders. Obesity, insulin resistance, lipid peroxidation
and oxidative stress have been identified amongst the possible hits leading to
the onset and progression of this disease. Nutritional evaluation of NAFLD
patients showed a lower-than-recommended intake of vitamin E. Vitamin E is a
family of 8 isoforms, 4 tocopherols and 4 tocotrienols. Alpha-tocopherol has
been widely investigated in liver diseases, whereas no previous clinical trial
has investigated tocotrienols for NAFLD ... The treatment, either mixed
tocotrienols 200 mg twice daily or placebo, had a 1-year duration ... As primary
outcome, the normalisation of hepatic echogenic response was significantly
higher for the tocotrienols treated group compared to the placebo group in the
intention to treat analysis (P = 0.039; 95% CI = 0.896-6.488). As secondary
objective, the per protocol assessment also showed significant rate of remission
(P = 0.014; 95% CI = 1.117-9.456). Worsening of NAFLD grade was recorded in two
patients in the placebo group, but none in the group treated with tocotrienols"
- See
mixed tocopherols at Amazon.com.
My favorite is
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Effects of
α-tocopherol and β-carotene supplementation on cancer incidence and mortality:
18-Year postintervention follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer
Prevention Study - Int J Cancer. 2013 Dec 3 - "In
the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study among 29,133 Finnish
male smokers aged 50-69 years, daily α-tocopherol (50 mg) for a median of 6.1
years decreased the risk of prostate cancer, whereas β-carotene (20 mg)
increased risk of lung cancer and overall mortality. To determine the
postintervention effects of α-tocopherol and β-carotene, 25,563 men were
followed 18 years for cancer incidence and all causes of mortality through
national registers ... In conclusion, supplementation with α-tocopherol and
β-carotene appeared to have no late effects on cancer incidence. The preventive
effect of moderate-dose α-tocopherol on prostate cancer continued several years
post-trial and resulted in lower prostate cancer mortality"
-
Serum levels of vitamin E
forms and risk of cognitive impairment in a Finnish cohort of older adults
- Exp Gerontol. 2013 Dec;48(12):1428-35 - "A sample of
140 non-cognitively impaired elderly subjects derived from the Cardiovascular
Risk Factors, Aging, and Dementia (CAIDE) study was followed-up for 8years to
detect cognitive impairment, defined as development of mild cognitive impairment
(MCI) or Alzheimer's dementia. The association between baseline serum vitamin E
and cognitive impairment was analyzed with multiple logistic regression after
adjusting for several confounders ... Elevated levels of tocopherol and
tocotrienol forms are associated with reduced risk of cognitive impairment in
older adults. The association is modulated by concurrent cholesterol
concentration. Various vitamin E forms might play a role in cognitive
impairment, and their evaluation can provide a more accurate measure of vitamin
E status in humans" - [Nutra
USA]
-
Intake and
serum concentrations of α-tocopherol in relation to fractures in elderly women
and men: 2 cohort studies - Am J Clin Nutr. 2013 Nov 13 -
"Two cohort studies, the Swedish Mammography Cohort
(SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM;
n = 1138 men), were used ... A higher hip fracture rate was observed with lower
intakes of α-tocopherol. Compared with the highest quintile of intake, the
lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06).
The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing
supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95%
CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with
the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower
intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR:
3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The
HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58
(95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48)"
-
Lower
dietary vitamin E intake during the second trimester is associated with insulin
resistance and hyperglycemia later in pregnancy - Eur J Clin Nutr. 2013 Sep
25 - "Women with singleton pregnancies (n=205) underwent
a 3-h oral glucose tolerance test at 30 weeks gestation and were asked to recall
second trimester dietary intake ... Higher dietary vitamin E intake was
associated with lower fasting glucose, lower HOMA insulin resistance, and higher
Matsuda insulin sensitivity index after covariate adjustment including serum
adiponectin among women consuming daily multivitamin supplements"
-
Green Tea
and Vitamin E Enhance Exercise-Induced Benefits in Body Composition, Glucose
Homeostasis, and Antioxidant Status in Elderly Men and Women - J Am Coll
Nutr. 2013 Feb;32(1):31-40 - "For 12 weeks, 22 elderly
men and women (age: 71.1 +/- 1.2 years; body mass index: 28.3 +/- 0.5 kg/m(2)
[mean +/- SE]) undertook 30 minutes of moderately intense walking 6 d/wk. They
were randomly assigned to ingest either green tea plus vitamin E (GTVE; 3 cups
and 400 IU, respectively; n = 11) or placebo (n = 11) ... Though dietary intake
was unchanged, improved exercise capacity was followed by a significant
reduction in body weight and fasting insulin levels in all participants.
Additional consumption of GTVE resulted in a twofold increase in serum vitamin E
(from 20.4 to 40.6 μmol/L, p < 0.001) and a decrease of men's and women's waist
circumferences (from 100.8 and 95.7 to 96.9 and 85.0 cm, p < 0.05 and p < 0.01,
respectively) and fasting glucose levels (from 5.30 to 4.98 mmol/L, p < 0.01)"
- Note the decrease in waist circumference from 95.7 to 85.0 cm in men. That's
a 10.7 cm reduction or 4.2 inches. - See
green tea extract at Amazon.com and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Effects of tocotrienol and
lovastatin combination on osteoblast and osteoclast activity in
estrogen-deficient osteoporosis - Evid Based Complement Alternat Med.
2012;2012:960742 - "48 Sprague Dawley female rats were
randomly divided into 6 groups ... Delta-tocotrienol plus lovastatin treatment
significantly increased bone formation and reduced bone resorption compared to
the other groups. Therefore, the combined treatment may have synergistic or
additive effects and have the potential to be used as an antiosteoporotic agent
in patients who are at risk of both osteoporosis and hypercholesterolemia,
especially in postmenopausal women"
-
Vitamin E
δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre
(KPC) transgenic mouse model of pancreatic cancer - Cancer Prev Res (Phila).
2013 Aug 20 - "Previous work has shown that vitamin E
δ-tocotrienol (VEDT) prolongs survival and delays progression of pancreatic
cancer in the LSL-KrasG12D/+;Pdx-1-Cre mouse model of pancreatic cancer ... KPC
mice were randomized into 4 groups: 1) vehicle (olive oil, 1.0 mL/kg PO
twice/day and PBS 1.0 mL/kg IP twice/week), 2) gemcitabine (100 mg/kg IP
twice/week), 3) VEDT (200 mg/kg PO twice/day), and 4) gemcitabine + VEDT ... At
16 weeks, survival was 10% in the vehicle group, 30% in the gemcitabine group,
70% in the VEDT group (P<0.01), and 90% in the VEDT combined with gemcitabine
group (P<0.05). VEDT alone and combined with gemcitabine resulted in reversal of
epithelial-to-mesenchymal transition in tumors --- These results strongly
support further investigation of VEDT alone and in combination with gemcitabine
for pancreatic cancer prevention and treatment"
-
α-Tocopherol does not
Accelerate Depletion of γ-Tocopherol and Tocotrienol or Excretion of their
Metabolites in Rats - Lipids. 2013 Jul;48(7):687-95 -
"These data showed that dietary α-tocopherol did not
accelerate the depletion of γ-tocopherol and tocotrienol and their metabolite
excretions, suggesting that the positive effect of α-tocopherol on vitamin E
ω-hydroxylase is not sufficient to affect the other isoform concentrations in
tissues"
- [Nutra
USA] - Note: As with other studies, I wouldn't put my eggs in one basket.
Saturating the mice with that much gamma before testing the depletion with the
alpha doesn't sound like a real life scenario.
-
Association
of blood antioxidants and vitamins with risk of age-related cataract: a
meta-analysis of observational studies - Am J Clin Nutr. 2013 Jul 10 -
"searched PubMed, EMBASE, and the Web of Science for
relevant studies ... A pooled estimate showed vitamin E (OR: 0.75; 95% CI: 0.58,
0.96), α-carotene (OR: 0.72; 95% CI: 0.59, 0.88), lutein (OR: 0.75; 95% CI:
0.65, 0.87), and zeaxanthin (OR: 0.70; 95% CI: 0.60, 0.82) were inversely
associated with age-related cataract. Vitamins A (OR: 0.69; 95% CI: 0.58, 0.83)
and C (OR: 0.67; 95% CI: 0.57, 0.78) were inversely associated with age-related
cataract in Asian populations but not in Western populations. β-Carotene (OR:
0.90; 95% CI: 0.78, 1.05), lycopene (OR: 0.86; 95% CI: 0.65, 1.15), and
β-cryptoxanthin (OR: 0.83; 95% CI: 0.68, 1.02) had no significant association
with risk of cataract" - See
Jarrow Formulas, CarotenALL at Amazon.com
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Lower vitamin E serum
levels are associated with osteoporosis in early postmenopausal women: a
cross-sectional study - J Bone Miner Metab. 2013 Mar 28 -
"BMD of the lumbar spine was significantly higher in the
highest tertile of the vitamin E:lipid ratio than in the lowest tertile. The
mean vitamin E:lipid ratio was significantly lower in osteoporotic
postmenopausal women (T score ≤-2.5) (3.0 +/- 0.6 μmol/mmol) than normal
(neither osteoporotic nor osteopenic) postmenopausal women (T score >-1) (3.5
+/- 0.7 μmol/mmol) using multivariable-adjusted BMD. These findings highlight
that vitamin E may increase BMD in healthy postmenopausal women"
-
Low vitamin
and carotenoid levels are related to cerebral white matter lesions - J Nutr
Health Aging. 2013;17(5):456-60 - "To determine the
effects of vitamins and carotenoids on brain white matter lesions (WMLs), we
examined the associations between WMLs with vitamin and carotenoid levels in
Japanese middle-aged and elderly subjects ... Deep white matter lesions (DWLs)
... Lower gamma-tocopherol levels were significantly associated with DWLs in all
subjects. While lower gamma-tocopherol and vitamin C levels were significantly
associated with DWLs in males, lower delta-tocopherol levels were associated
with DWLs in females. The associations between DWLs and lower gamma- and
delta-tocopherol and vitamin C levels were independent of age, hypertension, or
smoking. However, the associations between DWLs and lower alfa-tocopherol were
not significant following adjustments for smoking" - Note: Most
supplements only contain alfa-tocopherol which had no affect.
-
Atorvastatin
improves erectile dysfunction in patients initially irresponsive to Sildenafil
by the activation of endothelial nitric oxide synthase - Int J Impot Res.
2013 Jan 17 - "This study aimed at comparing the effects
of atorvastatin and vitamin E on erectile dysfunction in patients initially
irresponsive to sildenafil, with investigation into the underlying possible
mechanisms. Sixty patients were randomly divided into three groups: the
atorvastatin group received 80 mg daily, the vitamin E group received 400 IU
daily and the control group received placebo capsules ... glutathione peroxidase
(GPO) ... nitric oxide (NO) ... Both atorvastatin and vitamin E showed a
statistically significant GPO increase (P<0.05) and a statistically significant
IL-6 decrease (P<0.05). Only atorvastatin showed a statistically significant
increase in NO (15.19%, P<0.05), eNOS (20.58%, P<0.01), IIEF-5 score (53.1%,
P<0.001) and Rigiscan rigidity parameters (P<0.01), in addition to a
statistically significant decrease in CRP (57.9%, P<0.01). However, SOD showed a
statistically significant increase only after vitamin E intake (23.1%, P<0.05).
Both atorvatstain and vitamin E had antioxidant and anti-inflammatory
activities. Although activating eNOS by atorvastatin was the real difference,
and expected to be the main mechanism for NO increase and for improving erectile
dysfunction"
-
Associations
of intake of antioxidant vitamins and fatty acids with asthma in pre-school
children - Public Health Nutr. 2012 Oct 1:1-6 -
"Compared with children with the lowest intake tertile for vitamin C and vitamin
E, those in the highest were significantly inversely associated with asthma;
adjusted OR (95 % CI) were 0.35 (0.14, 0.88) and 0.32 (0.12, 0.85),
respectively. A statistically significant trend was also observed. Fruit intake
showed an inverse but insignificant association with asthma. There were no
associations of any type of fatty acids with asthma" - See
vitamin C products at Amazon.com
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Tocopherols and
tocotrienols plasma levels are associated with cognitive impairment -
Neurobiol Aging. 2012 Oct;33(10):2282-90 - "Vitamin E
includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential
neuroprotective activity. α-Tocopherol has mainly been investigated in relation
to cognitive impairment ... Low plasma tocopherols and tocotrienols levels are
associated with increased odds of MCI and AD" - [Nutra
USA]
-
Effects of
vitamin E on bone turnover markers among US postmenopausal women - J Bone
Miner Res. 2012 Feb 3 - "Increased oxidative stress and
inflammation resulting from aging and declining estrogen levels can lead to
increased bone loss in postmenopausal women. Alpha- and gamma-tocopherol, the
two predominant isomers of vitamin E, have antioxidant and anti-inflammatory
properties, but their effects on bone metabolism have not been well studied in
humans. We examined the associations between dietary and total (diet and
supplements) alpha-tocopherol intake, serum alpha- and gamma-tocopherol levels
and their ratio, and bone turnover markers (BTMs) among postmenopausal women
aged ≥45 years ... serum bone-specific alkaline phosphatase (BAP), a biomarker
of bone formation, and urinary N-telopeptides/creatinine (uNTx/Cr), a biomarker
of bone resorption ... Participants had a mean age of 65.5 +/- 0.6 years and
over 45% used vitamin E (alpha-tocopherol) supplements in the past month.
Vitamin E supplement users had significantly lower serum gamma-tocopherol,
higher serum alpha-tocopherol levels and higher ratio of serum alpha- to
gamma-tocopherol than nonusers. High serum gamma-tocopherol levels and low ratio
of serum alpha- to gamma-tocopherol were associated with increased BAP levels
(P < 0.01 for both). There were no associations between any of the vitamin E
variables and uNTx/Cr. In conclusion, we hypothesize that gamma-tocopherol may
uncouple bone turnover, resulting in more bone formation than resorption.
Vitamin E supplements in the form of alpha-tocopherol suppress serum
gamma-tocopherol levels and may have negative effects on bone formation. Further
research is needed to investigate the potential anabolic effect of
gamma-tocopherol from food sources on bone" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Oral
Tocotrienols Are Transported to Human Tissues and Delay the Progression of the
Model for End-Stage Liver Disease Score in Patients - J Nutr. 2012 Feb 1 -
"The natural vitamin E family is composed of 8 members
equally divided into 2 classes: tocopherols (TCP) and tocotrienols (TE). A
growing body of evidence suggests TE possess potent biological activity not
shared by TCP. The primary objective of this work was to determine the
concentrations of TE (200 mg mixed TE, b.i.d.) and TCP [200 mg α-TCP, b.i.d.)]
in vital tissues and organs of adult humans receiving oral supplementation ...
α-TE was delivered to human brain at a concentration reported to be
neuroprotective in experimental models of stroke. In prospective liver
transplantation patients, oral TE lowered the Model for end-stage liver disease
(MELD) score in 50% of patients supplemented, whereas only 20% of
TCP-supplemented patients demonstrated a reduction in MELD score. This work
provides, to our knowledge, the first evidence demonstrating that orally
supplemented TE are transported to vital organs of adult humans. The findings of
this study, in the context of the current literature, lay the foundation for
Phase II clinical trials testing the efficacy of TE against stroke and end-stage
liver disease in humans" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Vitamin E is
a MIF Inhibitor - Biochem Biophys Res Commun. 2012 Jan 18 -
"Macrophage migration inhibitory factor (MIF) is known
to contribute to the pathogenesis of inflammatory hyperalgesia and neuropathic
pain ... Vitamin E inhibits not only the enzymatic activity of MIF but more
importantly the biological function of MIF. Our findings suggest that Vitamin E
may be attenuating hyperalgesia and reducing neuropathic pain at least in part
by inhibiting MIF activity"
-
Vitamin E
and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention
Trial (SELECT) - JAMA. 2011 Oct 12;306(14):1549-56 -
"Oral selenium (200 μg/d from L-selenomethionine) with matched vitamin E
placebo, vitamin E (400 IU/d of all rac-α-tocopheryl acetate) with matched
selenium placebo, both agents, or both matched placebos for a planned follow-up
of a minimum of 7 and maximum of 12 years ... This report includes 54,464
additional person-years of follow-up and 521 additional cases of prostate cancer
since the primary report. Compared with the placebo (referent group) in which
529 men developed prostate cancer, 620 men in the vitamin E group developed
prostate cancer (hazard ratio [HR], 1.17; 99% CI, 1.004-1.36, P = .008); as did
575 in the selenium group (HR, 1.09; 99% CI, 0.93-1.27; P = .18), and 555 in the
selenium plus vitamin E group (HR, 1.05; 99% CI, 0.89-1.22, P = .46). Compared
with placebo, the absolute increase in risk of prostate cancer per 1000
person-years was 1.6 for vitamin E, 0.8 for selenium, and 0.4 for the
combination" - Note: The study used rac-α-tocopheryl acetate. See my
vitamin E page for several articles regarding taking only one of the eight
forms of vitamin E. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
-
Natural
Vitamin E {alpha}-Tocotrienol Protects Against Ischemic Stroke by Induction of
Multidrug Resistance-Associated Protein 1 - Stroke. 2011 Jun 30 -
"α-Tocotrienol (TCT) represents the most potent
neuroprotective form of natural vitamin E that is Generally Recognized As Safe
certified by the U.S. Food and Drug Administration ... This work recognizes MRP1
as a protective factor against stroke. Furthermore, findings of this study add a
new dimension to the current understanding of the molecular bases of α-TCT
neuroprotection in 2 ways: by identifying MRP1 as a α-TCT-sensitive target and
by unveiling the general prospect that oral α-TCT may regulate miR expression in
stroke-affected brain tissue" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Induction of
Apoptosis by γ-Tocotrienol in Human Cancer Cell Lines and Leukemic Blasts From
Patients: Dependency on Bid, Cytochrome c, and Caspase Pathway - Nutr
Cancer. 2011 Jun 9:1 - "Tocotrienols (Toc3) have been
suggested to possess anticancer effects besides antioxidant and antiinflammatory
effects. Previous studies have demonstrated that Toc3 induce apoptosis in
epithelial carcinoma. However, the effects of Toc3 on malignant hematopoietic
cells have not yet been thoroughly investigated. We investigated Toc3-induced
apoptosis in human hematological cancer cell lines. α-, δ-, and γ-Toc3 induced
concentration-dependent apoptosis, and γ-Toc3 demonstrated more effective
induction than the other Toc3 derivatives in HL-60 cells. γ-Toc3 may have
induced apoptosis by activation of the caspase cascade, cytochrome c (Cyt.c)
release, Bid cleavage, and mitochondorial membrane depolarization in HL-60,
NB-4, Raji, and SY-5Y cells. Furthermore, 10-30 μM γ-Toc3 showed cytotoxicity
for leukemic cells from various patients regardless of lymphoblastic,
myeloblastic, or relapsed leukemia, but the cytotoxic effect was weak in normal
mononuclear cells, interestingly. γ-Toc3 may have a role in cancer prevention
and potential for treating hematological malignancies" - Note: The γ is
the gamma symbol.
-
A Dietary
Mixture Containing Fish Oil, Resveratrol, Lycopene, Catechins, and Vitamins E
and C Reduces Atherosclerosis in Transgenic Mice - J Nutr. 2011 Mar 16 -
"Chronic inflammation and proatherogenic lipids are
important risk factors of cardiovascular disease (CVD). Specific dietary
constituents such as polyphenols and fish oils may improve cardiovascular risk
factors and may have a beneficial effect on disease outcomes ... AIDM was
evaluated in an inflammation model, male human C-reactive protein (CRP)
transgenic mice, and an atherosclerosis model, female ApoE*3Leiden transgenic
mice. Two groups of male human-CRP transgenic mice were fed AIDM [0.567% (wt:wt)
powder and 0.933% (wt:wt oil)] or placebo for 6 wk. The effects of AIDM on basal
and IL-1β-stimulated CRP expression were investigated. AIDM reduced
cytokine-induced human CRP and fibrinogen expression in human-CRP transgenic
mice. In the atherosclerosis study, 2 groups of female ApoE*3Leiden transgenic
mice were fed an atherogenic diet supplemented with AIDM [0.567% (wt:wt) powder
and 0.933% (wt:wt oil)] or placebo for 16 wk. AIDM strongly reduced plasma
cholesterol, TG, and serum amyloid A concentrations compared with placebo.
Importantly, long-term treatment of ApoE*3Leiden mice with AIDM markedly reduced
the development of atherosclerosis by 96% compared with placebo. The effect on
atherosclerosis was paralleled by a reduced expression of the vascular
inflammation markers and adhesion molecules inter-cellular adhesion molecule-1
and E-selectin. Dietary supplementation of AIDM improves lipid and inflammatory
risk factors of CVD and strongly reduces atherosclerotic lesion development in
female transgenic mice" - See
resveratrol products at Amazon.com,
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com,
Jarrow Formulas, CarotenALL at Amazon.com,
green tea extract at Amazon.com
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by
increasing intracellular dihydrosphingosine and dihydroceramide - Int J
Cancer. 2011 Mar 11 - "Although cell-based studies have
shown that γ-tocotrienol (γTE) exhibits stronger anticancer activities than
other forms of vitamin E including γ-tocopherol (γT), the molecular bases
underlying γTE-exerted effects remains to be elucidated ... In agreement with
these cell-based studies, γTE inhibited LNCaP xenograft growth by 53% (P<0.05),
compared with 33% (P = 0.07) by γT, in nude mice. These findings provide a
molecular basis of γTE-stimulated cancer-cell death and support the notion that
elevation of intracellular dihydroceramide and dihydrosphingosine is likely a
novel anticancer mechanism"
-
Effect of
vitamins C and E on antioxidant status of breast-cancer patients undergoing
chemotherapy - J Clin Pharm Ther. 2011 Jan 4 - "VCE
(vitamin C 500 mg tablet and vitamin E 400 mg gelatin capsule ... The untreated
group showed significantly lower levels of antioxidant enzymes (P<0.001) and
reduced glutathione (P<0.001), and more extensive lipid peroxidation (P<0.001)
and DNA damage than healthy controls. Similar but less pronounced patterns were
observed in the patients receiving chemotherapy alone. The group of patients
receiving VCE supplementation had all the marker levels moving towards normal
values. Activities of superoxide dismutase, catalase, glutathione-S-transferase
and glutathione reductase, and the levels of reduced glutathione were
significantly increased (P<0.01) while, the levels of malondialdehyde and DNA
damage were significantly (P<0.01) reduced in the VCE supplemented group
relative to those of patients receiving chemotherapy alone as well as relative
to the pretreatment levels"
-
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3
signalling pathway in human hepatocellular carcinoma: potential role as an
anti-proliferative, pro-apoptotic and chemosensitizing agent - Br J
Pharmacol. 2010 Dec 30 - "Overall, these results suggest
that γ-tocotrienol is a novel blocker of the STAT3 activation pathway, with a
potential role in future therapies for HCC and other cancers" - Note: The
γ symbol stands for gamma. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Tocotrienols
inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of
female mice - Lipids Health Dis. 2010 Dec 16;9(1):143 -
"The present results clearly demonstrate that alpha-,
gamma-, or delta-tocotrienol treatments inhibit the chymotrypsin-like activity
of 20S rabbit muscle proteasomes ... These results represent a novel approach by
using natural products, such as tocotrienols as proteasome modulators, which may
lead to the development of new dietary supplements of tocotrienols for
cardiovascular diseases as well as others that are based on inflammation"
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Effects
of supplementation with tocotrienol-rich fraction on immune response to tetanus
toxoid immunization in normal healthy volunteers - Eur J Clin Nutr. 2010 Sep
22 - "Volunteers supplemented with TRF showed a
significantly (P<0.05) enhanced production of interferon-γ and interleukin
(IL)-4 by the mitogen or TT-stimulated leukocytes compared with the control
group. Volunteers from the TRF group produced significantly (P<0.05) lower
amounts of IL-6 compared with the placebo group. Anti-TT IgG production was also
significantly (P<0.05) augmented in the TRF-supplemented group compared with the
placebo group" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
The value of
tocotrienols in the prevention and treatment of cancer - J Am Coll Nutr.
2010 Jun;29(3 Suppl):324S-333S - "Tocopherols and
tocotrienols represent the 2 subgroups that make up the vitamin E family of
compounds, but only tocotrienols display potent anticancer activity" -
See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
-
Palm
oil-derived natural vitamin E alpha-tocotrienol in brain health and disease
- J Am Coll Nutr. 2010 Jun;29(3 Suppl):314S-323S - "the
scientific literature on tocotrienols accounts for roughly 1% of the total
literature on vitamin E, thus warranting further investment and investigation"
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
-
Intake of fatty acids and
antioxidants and pancreatic cancer in a large population-based case-control
study in the San Francisco Bay Area - Int J Cancer. 2010 Oct
15;127(8):1893-904 - "Positive associations were
observed for high levels of the 8 individual saturated fatty acids (4th vs. 1st
quartile: ORs ranged from 1.6 to 2.6; all p(trend) < 0.01), monounsaturated
palmitoleic and oleic fatty acids [OR = 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI:
1.1-1.9); both p(trend) < 0.01], and polyunsaturated linolenic acid [OR = 1.5
(95% CI: 1.1-2.0); p(trend) = 0.02]. Inverse associations were observed for high
levels of gadolic acid [4th vs. 1st quartile: OR = 0.68 (95% CI: 0.50-0.92);
p(trend) = 0.007] and omega-3 fatty acids [>or=0.85 g/day vs. 1st quartile: OR =
0.47 (95% CI: 0.25-0.90)]. An inverse association was also observed for high
total intake of vitamin C [4th vs. 1st quartile: OR = 0.69 (95% CI: 0.51-0.94);
p(trend) = 0.004] and of vitamin E [OR = 0.67 (95% CI: 0.49-0.92); p(trend) =
0.01]"
-
{gamma}-Tocotrienol but not {gamma}-tocopherol blocks STAT3 cell signaling
pathway through induction of protein tyrosine phosphatase SHP-1 and sensitizes
tumor cells to chemotherapeutic agents - J Biol Chem. 2010 Aug 18 -
"We found that gamma-T3 but not gamma-tocopherol, the
most common saturated form of Vitamin E, inhibited constitutive activation of
STAT3 in a dose- and time-dependent manner and this inhibition was not cell type
specific. gamma-T3 also inhibited STAT3 DNA binding ... This vitamin also
sensitized the tumor cells to the apoptotic effects of thalidomide and
bortezomib. Overall, our results suggest that gamma-T3 is a novel blocker of
STAT3 activation pathway in both in vitro and in vivo and thus may have
potential in prevention and treatment of cancers" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
-
Mixed
Tocotrienols Inhibit Prostate Carcinogenesis in TRAMP Mice - Nutr Cancer.
2010 Aug;62(6):789-94 - "mixed-tocotrienol-fed groups
had a lower incidence of tumor formation along with a significant reduction in
the average wet weight of genitourinary apparatus. Furthermore, mixed
tocotrienols significantly reduced the levels of high-grade neoplastic lesions
as compared to the positive controls. This decrease in levels of high-grade
neoplastic lesions was found to be associated with increased expression of
proapoptotic proteins BAD (Bcl(2) antagonist of cell death) and cleaved
caspase-3 and cell cycle regulatory proteins cyclin dependent kinase inhibitors
p21 and p27. In contrast, the expression of cyclins A and E were found to be
decreased in mixed-tocotrienol groups. Taken together, our results show that by
modulating cell cycle regulatory proteins and increasing expression of
proapoptotic proteins, mixed tocotrienols suppress prostate tumorigenesis in the
TRAMP mice" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
-
Dietary
Antioxidants and Long-term Risk of Dementia - Arch Neurol. 2010
Jul;67(7):819-25 - "Compared with participants in the
lowest tertile of vitamin E intake, those in the highest tertile were 25% less
likely to develop dementia (hazard ratio, 0.75"
-
Gamma-tocotrienol as an effective agent in targeting prostate cancer stem
cell-like population - Int J Cancer. 2010 Jul 8 -
"Emerging evidence supports that prostate cancer originates from a rare
sub-population of cells, namely prostate cancer stem cells (CSCs). Conventional
therapies for prostate cancer are believed to mainly target the majority of
differentiated tumor cells but spare CSCs, which may account for the subsequent
disease relapse after treatment. Therefore, successful elimination of CSCs may
be an effective strategy to achieve complete remission from this disease.
Gamma-tocotrienols (gamma-T3) is one of the vitamin-E constituents which have
been shown to have anticancer effects against a wide-range of human cancers.
Recently, we have reported that gamma-T3 treatment not only inhibits prostate
cancer cell invasion but also sensitizes the cells to docetaxel-induced
apoptosis, suggesting that gamma-T3 may be an effective therapeutic agent
against advanced stage prostate cancer. Here, we demonstrate for the first time
that gamma-T3 can down-regulate the expression of prostate CSC markers
(CD133/CD44) in androgen independent (AI) prostate cancer cell lines (PC-3 &
DU145), as evident from western blotting analysis. Meanwhile, the spheroid
formation ability of the prostate cancer cells was significantly hampered by
gamma-T3 treatment. In addition, pre-treatment of PC-3 cells with gamma-T3 was
found to suppress tumor initiation ability of the cells. More importantly, while
CD133-enriched PC-3 cells were highly resistant to docetaxel treatment, these
cells were as sensitive to gamma-T3 treatment as the CD133-depleted population.
Our data suggest that gamma-T3 may be an effective agent in targeting prostate
CSCs, which may account for its anticancer and chemosensitizing effects reported
in previous studies" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
-
Gamma
Tocopherol Upregulates the Expression of 15-S-HETE and Induces Growth Arrest
Through a PPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells
- Nutr Cancer. 2009;61(5):649-62 - "These data
demonstrate that the growth arrest mediated by gamma-tocopherol follows a
PPAR-gamma-dependent mechanism" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
delta-Tocotrienol Suppresses VEGF Induced Angiogenesis whereas
alpha-Tocopherol Does Not - J Agric Food Chem. 2009 Aug 25 -
"Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained
considerable attention as a potent antiangiogenic agent. However, the
majority of vitamin E research has focused on tocopherol (Toc) ... We showed
delta-T3 (2.5-5 muM) completely abolished proliferation, migration and tube
formation of human umbilical vein endothelial cells (HUVECs), whereas a
similar dose of alpha-Toc had no such effects. delta-T3 suppressed VEGF
receptor 2 (VEGFR-2) signaling, and activated caspases in HUVECs. In
addition, via an in vivo mouse Matrigel plug angiogenesis assay, we found
that delta-T3 (30 mug), but not alpha-Toc, inhibited tumor cell-induced
vessel formation. In summary, our results demonstrate delta-T3 has superior
antiangiogenic activities to alpha-Toc, and provide insights into the
different mechanisms responsible for this effect of T3 and Toc" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Antioxidant vitamins and the risk of endometrial cancer: a dose-response
meta-analysis - Cancer Causes Control. 2009 Jul;20(5):699-711 -
"Based on case-control data, the random-effects
summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98)
per 1,000 mcg/1,000 kcal (I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI:
0.73-0.98) per 50 mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E:
0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
-
Multivitamin use and telomere length in women - Am J Clin Nutr. 2009
Jun;89(6):1857-63 - "After age and other potential
confounders were adjusted for, multivitamin use was associated with longer
telomeres. Compared with nonusers, the relative telomere length of leukocyte
DNA was on average 5.1% longer among daily multivitamin users (P for trend =
0.002). In the analysis of micronutrients, higher intakes of vitamins C and
E from foods were each associated with longer telomeres, even after
adjustment for multivitamin use. Furthermore, intakes of both nutrients were
associated with telomere length among women who did not take multivitamins"
-
Specific accumulation of gamma- and delta-tocotrienols in tumor and their
antitumor effect in vivo - J Nutr Biochem. 2008 Sep 26 -
"In C3H/HeN mice implanted with MH134, it was found
that gamma-T3 and delta-T3 feeding significantly delayed tumor growth ...
Intriguingly, we found that T3 was detected in tumor, but not in normal
tissues. These results, to our knowledge, are the first demonstration of
specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3
accumulation is critical for the antitumor activities of T3" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
The
response of gamma vitamin E to varying dosages of alpha vitamin E plus
vitamin C - Metabolism. 2009 Apr;58(4):469-78 -
"vitamin E has several isomers, with the alpha form being available via
dietary supplements and the gamma form being available via dietary
foodstuffs. The gamma form of vitamin E demonstrates several superior
properties (such as trapping reactive nitrogen species and detoxifying
nitrogen dioxide) compared with alpha vitamin E. All clinical trials have
used the alpha isomer, with little concern that this isomer of vitamin E may
actually suppress the gamma isomer of vitamin E ... The results demonstrate
that alpha vitamin E levels increased in proportion to the dose
administered. However, at every dose of alpha vitamin E, gamma vitamin E
concentration was significantly suppressed ... Our results suggest that all
prospective cardiovascular clinical trials that used vitamin E
supplementation actually suppressed the beneficial antioxidant gamma isomer
of vitamin E" - Dah!! I've been saying that for years. They're
finally catching on. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
gamma-Tocopherol-enriched mixed tocopherol diet inhibits prostate
carcinogenesis in TRAMP mice - Int J Cancer. 2008 Oct 27 -
"8 week old TRAMP males were fed 0.1%
gamma-T-enriched mixed tocopherol diet that contained 20-fold higher levels
of gamma-tocopherol, and roughly 3-fold higher levels of alpha-tocopherol
... Treatment with gamma-T-enriched mixed tocopherols significantly
suppressed the incidence of palpable tumor and Prostate Intraepithelial
Neoplasia (PIN) development without affecting the expression of the
transgene (SV-40) ... gamma-T-enriched mixed tocopherols significantly
up-regulated the expression of Nrf2 and its related detoxifying and
antioxidant enzymes thereby suppressing PIN and tumor development" -
Note: One previous study was done with alpha-tocopherol. I cannot
understand why they did that when the previous research also supported the
gamma unless they didn't do any homework at all before planning the study.
See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
The
effect of vitamin E on the treatment of menstrual migraine - Med Sci
Monit. 2009 Jan;15(1):CR16-19 - "Vitamin E is
effective in relieving symptoms due to menstrual migraine"
-
Effect
of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal
adenocarcinoma formation in a rat surgical model - Int J Cancer. 2008
Oct 20 - "oxidative stress subsequent to
gastroesophageal reflux is an important driving force of esophageal
adenocarcinoma (EAC) formation in the esophagogastroduodenal anastomosis
(EGDA) rat model. This study investigated the possible tumor inhibitory
effects of 2 antioxidants, alpha-tocopherol (389 and 778 ppm),
N-acetylcysteine (NAC, 500 and 1,000 ppm), and their combination (389 and
500 ppm, respectively), as well as an antacid therapeutic agent, omeprazole
(1,400 ppm) ... alpha-Tocopherol dose-dependently decreased the incidence of
EAC (p = 0.03), with 778 ppm alpha-tocopherol reducing the incidence of EAC
to 59% (16/27) in comparison with 84% (26/31) in the control group (p =
0.04). Supplementation of alpha-tocopherol also increased the serum
concentration of alpha-tocopherol. NAC at 500 and 1,000 ppm did not
significantly decrease EAC incidence; however, the combination of
alpha-tocopherol 389 ppm and NAC 500 ppm significantly reduced the incidence
of EAC to 55% (15/27) (p = 0.02). alpha-Tocopherol alone or in combination
with NAC significantly reduced the number of infiltrating cells positively
stained for 4-hydroxynonenal. Omeprazole showed only a slight nonsignificant
inhibitory effect at the dose given"
-
Efficacy
of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease:
A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension -
Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We
examined the efficacy of a vitamin/nutriceutical formulation (folate,
vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and
acetyl-L-carnitine) in a 12-month, open-label trial with 14
community-dwelling individuals with early-stage Alzheimer's disease.
Participants improved in the Dementia Rating Scale and Clock-drawing tests
(Clox 1 and 2). Family caregivers reported improvement in multiple domains
of the Neuropsychiatric Inventory (NPI) and maintenance of performance in
the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL).
Sustained performance was reported by caregivers for those participants who
continued in an 16-month extension. Performance on the NPI was equivalent to
published findings at 3 to 6 months for donepezil and exceeded that of
galantamine and their historical placebos. Participants demonstrated
superior performance for more than 12 months in NPI and ADL versus those
receiving naproxen and rofecoxib or their placebo group. This formulation
holds promise for treatment of early-stage Alzheimer's disease prior to
and/or as a supplement for pharmacological approaches"
-
Antioxidant treatment
with alpha-tocopherol improves erectile function in hypertensive rats -
Hypertens Res. 2008 May;31(5):1007-13 - "Treatment
with 24 mg alpha-tocopherol decreased TBARS levels and increased SOD
activity in the serum and corpus cavernosum. Relaxation in response to
acetylcholine chloride in the corpus cavernosum was improved with
alpha-tocopherol treatment at each dose. These results suggest that
alpha-tocopherol treatment increases the diminished relaxation in the corpus
cavernosum of SHRs by improving neuronal or endothelial function related to
nitric oxide and carbon monoxide. This, in turn, indicates that antioxidant
therapy may play a role in treatment for ED in hypertensive patients"
-
Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk
- Int J Cancer. 2008 Jun 10 - "When we entered the
other tocopherols in our model, only the association with dietary
alpha-tocopherol intake remained significant; i.e., increasing intake of
dietary alpha-tocopherol accounted for 34-53% reductions in lung cancer
risk"
-
alpha- and gamma-Tocopherol prevent age-related transcriptional alterations
in the heart and brain of mice - J Nutr. 2008 Jun;138(6):1010-8 -
"In the heart, both tocopherol-supplemented diets
were effective in inhibiting the expression of genes previously associated
with cardiomyocyte hypertrophy and increased innate immunity. In the brain,
induction of genes encoding ribosomal proteins and proteins involved in ATP
biosynthesis was observed with aging and was markedly prevented by the
mixture of alphaT and gammaT supplementation but not by alphaT alone. These
results demonstrate that middle age-onset dietary supplementation with
alphaT and gammaT can partially prevent age-associated transcriptional
changes and that these effects are tissue and tocopherol specific"
-
Dietary carotenoids, vitamins C and e, and risk of cataract in women: a
prospective study - Arch Ophthalmol. 2008 Jan;126(1):102-9 -
"In these prospective observational data from a
large cohort of female health professionals, higher dietary intakes of
lutein/zeaxanthin and vitamin E from food and supplements were associated
with significantly decreased risks of cataract"
-
Alpha-tocopherol supplementation prevents the exercise-induced reduction of
serum paraoxonase 1/arylesterase activities in healthy individuals - Eur
J Clin Nutr. 2007 Sep 19 - "Alpha-T supplementation
may result in protection of the enzyme PON 1/Aryl activities from free
radical production"
-
Reduction of DNA damage in older healthy adults by Tri E((R)) Tocotrienol
supplementation - Nutrition. 2007 Sep 19 - "Tri
E((R)) Tocotrienol supplementation may be beneficial by reducing DNA damage
as indicated by a reduction in DNA damage, SCE frequency, and urinary
8-OHdG" - See my favorite
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
-
Alpha-tocopherol supplementation prevents the exercise-induced reduction of
serum paraoxonase 1/arylesterase activities in healthy individuals - Eur
J Clin Nutr. 2007 Sep 19 - "Alpha-T supplementation
may result in protection of the enzyme PON 1/Aryl activities from free
radical production"
-
Vitamin E dietary supplementation significantly affects multiple risk
factors for cardiovascular disease in baboons - Am J Clin Nutr. 2007
Sep;86(3):597-603 - "vitamin E caused 2 paradoxical
effects on HDL metabolism: higher apolipoprotein A-I (apo A-I)
concentrations and lower HDL sizes ... They also show 2 apparently
paradoxical effects on HDL metabolism: lower HDL(2), which is mediated by
genes, and higher apo A-I, which is not. These effects have contrasting
associations with CVD risk and may help account for the mixed results from
clinical trials of dietary vitamin E"
-
Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis
patients - J Ren Nutr. 2007 Sep;17(5):296-304 -
"gamma tocopherol (308 mg) and DHA (800 mg) ... In the treatment group, but
not in the placebo group, there were significant decreases in IL-6 (21.4 +/-
3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9
+/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4
+/- 0.3 10(3)/microL), at P < .05 for all"
-
Supplemental and dietary vitamin e intakes and risk of prostate cancer in a
large prospective study - Cancer Epidemiol Biomarkers Prev. 2007
Jun;16(6):1128-35 - "dietary gamma-tocopherol, the
most commonly consumed form of vitamin E in the United States, was
significantly inversely related to the risk of advanced prostate cancer (for
highest versus lowest quintile: RR, 0.68"
-
Supplementation with vitamins C and e improves arterial stiffness and
endothelial function in essential hypertensive patients - Am J
Hypertens. 2007 Apr;20(4):392-7 -
"Combined treatment with vitamins C and E has
beneficial effects on endothelium-dependent vasodilation and arterial
stiffness in untreated, essential hypertensive patients"
-
Effect of the main dietary antioxidants (carotenoids, gamma-tocopherol,
polyphenols, and vitamin C) on alpha-tocopherol absorption - Eur J Clin
Nutr. 2007 Jan 31 - "Naringenin, carotenoids and
probably gamma-tocopherol can impair alpha-tocopherol absorption whereas
vitamin C and phenolic acids have no effect"
-
The effect of vitamin E on blood pressure in individuals with type 2
diabetes: a randomized, double-blind, placebo-controlled trial - J
Hypertens. 2007 Jan;25(1):227-34 -
"Treatment with alpha-tocopherol significantly
increased systolic BP [7.0 (5.2, 8.8) mmHg, P < 0.0001], diastolic BP [5.3
(4.0, 6.5) mmHg, P < 0.0001], pulse pressure [1.8 (0.6, 3.0) mmHg, P <
0.005] and heart rate [2.0 (0.6, 3.3) bpm, P < 0.005] versus placebo.
Treatment with mixed tocopherols significantly increased systolic BP [6.8
(4.9, 8.6) mmHg, P < 0.0001], diastolic BP [3.6 (2.3, 4.9) mmHg, P <
0.0001], pulse pressure [3.2 (2.0, 4.4) mmHg, P < 0.0001] and heart rate
[1.8 (0.5, 3.2) bpm, P < 0.01] versus placebo"
-
Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C
Human Prostate Cancer Cells in Nude Mice
- J Nutr. 2006 May;136(5):1287-93 -
"lycopene combined with vitamin E may inhibit the
growth of prostate cancer"
-
Supplementation with mixed tocopherols increases serum and blood cell
{gamma}-tocopherol but does not alter biomarkers of platelet activation in
subjects with type 2 diabetes - Am J Clin Nutr. 2006 Jan;83(1):95-102 -
"Supplementation with alpha-tocopherol decreased red blood cell
gamma-tocopherol, whereas mixed tocopherols increased both serum
alpha-tocopherol and serum and cellular gamma-tocopherol"
-
Vitamin E Supplementation in Alzheimer's Disease, Parkinson's Disease,
Tardive Dyskinesia, and Cataract: Part 2 (December)
- Ann Pharmacother. 2005 Nov 15 - "We encourage
patients to supplement with vitamin E-rich foods. The use of a daily
multivitamin, which usually contains 30 IU of alpha-tocopherol, may be
beneficial; however, we discourage individual vitamin E supplements that
usually contain 400 IU of alpha-tocopherol"
-
The therapeutic impacts of tocotrienols in type 2 diabetic patients with
hyperlipidemia - Atherosclerosis. 2005 Oct;182(2):367-74 -
"tocotrienol rich fraction (TRF) ... After 60 days
of TRF treatment, subjects showed an average decline of 23, 30, and 42% in
serum total lipids, TC, and LDL-C, respectively ... daily intake of dietary
TRF by type 2 diabetics will be useful in the prevention and treatment of
hyperlipidemia and atherogenesis"
-
Vitamin E at high doses improves survival, neurological performance and
brain mitochondrial function in aging male mice - Am J Physiol Regul
Integr Comp Physiol. 2005 Jul 14 -
"Male mice receiving vitamin E (5.0 g
alpha-tocopherol acetate/kg of food) from 28 wk of age showed a 40 %
increased median lifespan ... and 17 % increased maximal lifespan, whereas
female mice equally supplemented exhibited only 14 % increased median
lifespan ... Vitamin E-supplemented male mice showed a better performance in
the tightrope (neuromuscular function) and the T-maze (exploratory activity)
tests" - [eurekalert.org]
-
Vitamin E in the primary prevention of cardiovascular disease and cancer:
the Women's Health Study: a randomized controlled trial - JAMA. 2005 Jul
6;294(1):56-65
-
The effect of gamma-tocopherol administration on alpha-tocopherol levels and
metabolism in humans - Eur J Clin Nutr. 2005 Jun 1 -
"The plasma alpha-tocopherol concentration decreased
significantly during gamma-tocopherol administration"
-
Vitamins E and C are safe across a broad range of intakes - Am J Clin
Nutr. 2005 Apr;81(4):736-45 -
"vitamin E supplements appear safe for most adults
in amounts </=1600 IU (1073 mg RRR-alpha-tocopherol or the molar equivalent
of its esters) and that vitamin C supplements of </=2000 mg/d are safe for
most adults"
-
A randomized trial of antioxidant vitamins to prevent second primary cancers
in head and neck cancer patients - J Natl Cancer Inst. 2005 Apr
6;97(7):481-8 - "alpha-Tocopherol supplementation
produced unexpected adverse effects on the occurrence of second primary
cancers and on cancer-free survival"
-
Effects of long-term vitamin E supplementation on cardiovascular events and
cancer: a randomized controlled trial - JAMA. 2005 Mar
16;293(11):1338-47
-
Dietary intake of vitamin C and vitamin E and the development of
hypertensive disorders of pregnancy - Eur J Obstet Gynecol Reprod Biol.
2005 Mar 1;119(1):67-71 - "Low vitamin E intake was
associated with a significant increase in the risk of hypertensive disorders
of pregnancy"
-
Vitamin E and respiratory tract infections in elderly nursing home
residents: a randomized controlled trial - JAMA. 2004 Aug
18;292(7):828-36
-
Supplementation of Diets with alpha-Tocopherol Reduces Serum Concentrations
of gamma- and delta-Tocopherol in Humans - J Nutr. 2003
Oct;133(10):3137-40 -
"Despite promising evidence from in vitro experiments
and observational studies, supplementation of diets with alpha-tocopherol
has not reduced the risk of cardiovascular disease and cancer in most
large-scale clinical trials. One plausible explanation is that the potential
health benefits of alpha-tocopherol supplements are offset by deleterious
changes in the bioavailability and/or bioactivity of other nutrients ...
Compared with placebo, supplementation with alpha-tocopherol reduced serum
gamma-tocopherol concentrations by a median change of 58% ... and reduced
the number of individuals with detectable delta-tocopherol concentrations
... In view of the potential benefits of gamma- and delta-tocopherol, the
efficacy of alpha-tocopherol supplementation may be reduced due to decreases
in serum gamma- and delta-tocopherol levels. Additional research is clearly
warranted" - This is what I've been saying for years yet they still
do nearly all the studies with the alpha-tocopherol.
-
Vitamin E supplementation increases LDL resistance to ex vivo oxidation in
hemodialysis patients - "Int J Vitam Nutr Res. 2003 Jul;73(4):290-6 -
"Since oral vitamin E supplementation prevents
oxidative stress and significantly increases LDL resistance to ex vivo
oxidation, supplementation by natural antioxidants such as vitamin E may be
beneficial in hemodialysis patients"
-
Oral Antioxidant Therapy Improves Endothelial Function in Type 1 but not
Type 2 Diabetes Mellitus - Am J Physiol Heart Circ Physiol. 2003
Dec;285(6):H2392-8. Epub 2003 Jul 24 -
"subjects were randomized to oral vitamin C 1000 mg
and vitamin E 800 IU daily or matching placebo for six months ... Oral
antioxidant therapy improves EDV in T1 but not T2 diabetes" - The
measurement of Vitamin E in IUs shows that they are still using
d-alpha-tocopherol or worse, the dl-alpha-tocopherol instead of mixed
tocopherols including the tocotrienols in studies. Just for starters, the
d-alpha lowers gamma.
-
Gamma-Tocopherol, the new vitamin E? - AJCN, 3/1/03
-
Non-nutritive bioactive food constituents of plants: tocopherols (vitamin E)
- Int J Vitam Nutr Res 2003 Mar;73(2):89-94 -
"in food, gamma- and delta-tocopherol are a more
potent antioxidant than alpha-tocopherol. Tocopherols as a group are the key
antioxidants in human cell membranes and are also important in protecting
the LDL particles"
-
Vitamin E prevents changes in the cornea and conjunctiva due to vitamin A
deficiency - Graefes Arch Clin Exp Ophthalmol 2003 Apr;241(4):287-97 -
"The present study suggests that vitamin E has a
protective effect against the corneal and conjunctival damage caused by
vitamin A deficiency"
-
High-dose antioxidant supplements and cognitive function in
community-dwelling elderly women - Am. J. of Clin. Nutr., 4/03 -
"Long-term, current users of vitamin E with
vitamin C had significantly better mean performance, as judged by a
global score that combined individual test scores, than did women who had
never used vitamin E or C (P = 0.03); there was a trend for increasingly
higher mean scores with increasing durations of use (P = 0.04). These
associations were strongest among women with low dietary intakes of
alpha-tocopherol. Benefits were less consistent for women taking vitamin E
alone, with no evidence of higher scores with longer durations of use. Use
of specific vitamin C supplements alone had little relation to performance
on our cognitive tests"
-
Mixed tocopherols inhibit platelet aggregation in humans: potential
mechanisms - AJCN, 3/1/03 -
"ADP-induced platelet aggregation decreased
significantly in the mixed tocopherol group but not in the alpha-tocopherol
and control groups ... Effects of mixed tocopherols were associated with
increased NO release, ecNOS activation, and SOD protein content in
platelets, which may contribute to the effect on platelet aggregation"
-
Antioxidants and Risk of Alzheimer Disease - JAMA, 11/13/02 -
"Dr Morris and colleagues1 and Dr Engelhart and
colleagues2 found an inverse relationship between intake of vitamin E from
food, but not from supplements, with risk of Alzheimer disease (AD).3 I
would like to suggest a mechanism for this finding. The predominant dietary
form of vitamin E, gamma-tocopherol, but not the form found in supplements,
alpha-tocopherol, has been demonstrated to inhibit cyclooxygenase 2 (COX-2)
production of prostaglandin E2 in macrophages and epithelial cells"
-
Association between alpha-tocopherol, gamma-tocopherol, selenium, and
subsequent prostate cancer - J Natl Cancer Inst. 2000 Dec
20;92(24):2018-23 -
"For gamma-tocopherol, men in the highest fifth of
the distribution had a fivefold reduction in the risk of developing prostate
cancer than men in the lowest fifth" - [Full
Article]
-
Effect of oral supplementation with D-alpha-tocopherol on the vitamin E
content of human low density lipoproteins and resistance to oxidation -
J Lipid Res. 1991 Aug;32(8):1325-32 -
"gamma-Tocopherol significantly decreased in plasma
and LDL during vitamin E (alpha-tocopherol) supplementation"
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