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Home > Health Conditions > Hearing Loss

Hearing Loss & Ear Infections

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  • Nanocurcumin substantially alleviates noise stress-induced anxiety-like behavior: the roles of tight junctions and NMDA receptors in the hippocampus - Behav Brain Res 2022 Jun 21 - "Environmental noise stress affects non-auditory brain regions such as the hippocampus; an area of the brain implicated in cognition and emotion. Recent experimental data indicate that dysfunction of the blood-brain barrier (BBB) and overexpression of NMDA receptors may cause anxiety. In this experiment, we evaluated the effect of nanocurcumin on anxiety-like behavior and the expression of tight junctions and NMDA receptor subunits in the hippocampus of rats exposed to traffic noise. Forty rats were assigned to control (CON), stress (ST), nanocurcumin (NC), and nanocurcumin+stress (NC+ST) groups ... Our findings showed that noise exposure promotes stress and anxiety and impairs the NMDA receptor structure and BBB integrity. The nanocurcumin treatment displayed partly restored the destructive effects of noise exposure" - See curcumin at Amazon.com.
  • Resveratrol Ameliorates Lipopolysaccharide-Induced Sudden Sensorineural Hearing Loss in In Vitro Model through Multitarget Antiapoptotic Mechanism Based on Network Pharmacology and Molecular Docking - Evid Based Complement Alternat Med 2022 May 19 - "To explore the effects of resveratrol (RSV) on hair cell apoptosis caused by sudden sensorineural hearing loss (SSNHL) and its effect on lipopolysaccharide-induced apoptosis of HEI-OC1 cells ... RSV mainly affects the prognosis of SSNHL through anti-inflammatory effects and may improve hair cell apoptosis caused by inflammatory factors through multitargeted interventions involving TNF, CASP3, AKT1, and TP53" - See resveratrol products at Amazon.com.
  • Low vitamin D status is associated with hearing loss in the elderly: a cross-sectional study - Am J Clin Nutr 2020 Nov 27 - "In the elderly, low vitamin D status was associated with low-frequency and speech-frequency HL. Low vitamin D status may be a potential risk factor for age-related HL" - See vitamin D at Amazon.com and vitamin D at iHerb.
  • Low Vitamin B12 level and Vitamin D level Adversely Affect on Cochlear Health in Women - Int J Vitam Nutr Res. 2019 Oct 18:1-6 - "There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function" - See vitamin B12 at Amazon.com and vitamin D at Amazon.com.
  • An Oral Combination of Vitamins A, C, E, and Mg++ Improves Auditory Thresholds in Age-Related Hearing Loss - Front Neurosci. 2018 Jul 31;12:527 - "chow enriched in ACEMg ("enhanced diet," ED) ... In the oldest animals, differences in the threshold shift persisted, as well as in the amplitude of the wave II, suggesting a protective effect of ACEMg on auditory function during aging. These findings indicate that oral ACEMg may provide an effective adjuvant therapeutic intervention for the treatment of ARHL, delaying the progression of hearing impairment associated with age" - [Nutra USA]
  • Low Iodine Intake Linked to Hearing Loss in US Teens - Medscape, 6/19/18 - "US teens with the lowest levels of urinary iodine were five-times more likely to have hearing loss associated with speech comprehension than their peers with higher iodine levels" - See iodine at Amazon.com.
  • Iron deficiency anemia associated with hearing loss - Science Daily, 12/29/16 - "iron deficiency anemia (IDA) is a common and easily correctable condition ... An association exists between IDA in adults and hearing loss" - See iron supplements at Amazon.com.
  • Low Iron Diet Increases Susceptibility to Noise-Induced Hearing Loss in Young Rats - Nutrients. 2016 Jul 28;8(8) - "iron deficiency (ID) ... spiral ganglion cells (SGCs) ... ID without anemia delayed the recovery from noise-induced hearing loss and ribbon synapses damage, increased SGCs loss, and upregulated prestin after noise exposure. Thus, the cochleae in rat pups with ID without anemia were potentially susceptible to loud noise exposure, and this deficit may be attributed to the reduction of ribbon synapses and SGCs" - See iron supplements at Amazon.com.
  • Vitamin supplement successfully prevents noise-induced hearing loss - Science Daily, 12/2/14 - "the researchers used the chemical nicotinamide riboside (NR) to protect the nerves that innervate the cochlea ... NR was successful at preventing damage to the synaptic connections, avoiding both short-term and long-term hearing loss. What's more, NR was equally effective regardless of whether it was given before or after the noise exposure ... The researchers chose NR because it is a precursor to the chemical compound nicotinamide adenine dinucleotide (NAD+), which had previously been shown by Dr. Brown and co-senior author Samie Jaffrey, MD, PhD, to protect cochlea nerve cells from injury. However, NAD+ is an unstable compound, calling into question whether it could be used out of the petri dish and in a live animal ... Beyond just preventing hearing loss, the researchers think the results may have broader applications because of the underlying way NR protects nerve cells ... The success of this study suggests that targeting SIRT3 using NR could be a viable target for treating all sorts of aging-related disorders--not only hearing loss but also metabolic syndromes like obesity, pulmonary hypertension, and even diabetes" - See nicotinamide adenine dinucleotide at Amazon.com and nicotinamide riboside at Amazon.com.
  • Fish and fatty acid consumption and the risk of hearing loss in women - Am J Clin Nutr. 2014 Nov;100(5):1371-7 - "Data were from the Nurses' Health Study II, a prospective cohort study ... In comparison with women who rarely consumed fish (<1 serving/mo), the multivariable-adjusted RR for hearing loss among women who consumed 2-4 servings of fish per week was 0.80 (95% CI: 0.74, 0.88) (P-trend < 0.001) ... In comparison with women in the lowest quintile of intake of long-chain omega-3 PUFAs, the multivariable-adjusted RR for hearing loss among women in the highest quintile was 0.85 (95% CI: 0.80, 0.91) and among women in the highest decile was 0.78 (95% CI: 0.72, 0.85) (P-trend < 0.001)" - See fish oil supplements at Amazon.com.
  • Fish, fatty acid consumption associated with lower risk of hearing loss in women - Science Daily, 9/10/14 - "Data were from the Nurses' Health Study II, a prospective cohort study. In the study, 65,215 women were followed from 1991 to 2009. After 1,038,093 person-years of follow-up, 11,606 cases of incident hearing loss were reported. In comparison with women who rarely consumed fish, women who consumed two or more servings of fish per week had a 20 percent lower risk of hearing loss. When examined individually, higher consumption of each specific fish type was inversely associated with risk. Higher intake of long-chain omega-3PUFA was also inversely associated with risk of hearing loss" - See fish oil supplements at Amazon.com.
  • Lutein and zeaxanthin status and auditory thresholds in a sample of young healthy adults - Nutr Neurosci. 2014 Jul 10 - "Dietary carotenoids lutein (L) and zeaxanthin (Z) have been linked to improved visual and cognitive function ... The overall pattern of results is consistent with a role for L and Z in maintaining optimal auditory function" - See carotenoids at Amazon.com.
  • Dietary vitamin intake correlates with hearing thresholds in the older population: the Korean National Health and Nutrition Examination Survey - Am J Clin Nutr. 2014 Mar 19 - "Previous animal studies have shown that vitamins may prevent age-related hearing loss. However, no concrete conclusions have been reached about the association between vitamin intake and presbycusis in humans ... data from the 2011 Korea National Health and Nutrition Examination Survey ... intake of vitamin C correlated with better hearing at midfrequency (2000 and 3000 Hz) (coefficient: -0.012; 95% CI: -0.022, -0.002). Dietary supplement use was positively associated with better hearing at all frequencies. The univariate analysis indicated that dietary intakes of retinol, riboflavin, niacin, and vitamin C were positively correlated with better hearing at most frequencies. In contrast, serum concentrations of vitamin D were associated with worse hearing at mid and high (4000 and 6000 Hz) frequencies"
  • Antioxidant vitamins and magnesium and the risk of hearing loss in the US general population - Am J Clin Nutr. 2013 Nov 6 - "The protective effects of antioxidant vitamins on hearing loss are well established in animal studies but in few human studies. Recent animal studies suggest that magnesium intake along with antioxidants may act in synergy to prevent hearing loss ... analyzed cross-sectional data from 2592 participants aged 20-69 y from NHANES 2001-2004 ... Dietary intakes of antioxidants and magnesium are associated with lower risks of hearing loss" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com and Jarrow Formulas, MagMind at Amazon.com.
  • Resveratrol shows promise to protect hearing, cognition - Science Daily, 2/20/13 - "Resveratrol is a very powerful chemical that seems to protect against the body's inflammatory process as it relates to aging, cognition and hearing loss ... Noise-induced hearing loss, too, is a growing medical issue among American troops, with more than 12 percent returning home from Iraq and Afghanistan with significant hearing loss ... acoustic over-stimulation causes a time-depended, up-regulation of COX-2 protein expression. And, resveratrol significantly reduces reactive oxygen species formation, inhibits COX-2 expression and reduces noise-induced hearing loss following noise exposure in rats" - See resveratrol products at Amazon.com.
  • Intake of specific nutrients and foods and hearing level measured 13 years later - Br J Nutr. 2012 Nov 19:1-10 - "hearing level (HL) ... We examined the 13-year association between intake of specific nutrients and food groups and HL in a sample of French adults ... Intakes of retinol (P-trend = 0.058) and vitamin B12 (P-trend = 0.068) tended to be associated with better HL in women. Intakes of meat as a whole (P-trend = 0.030), red meat (P-trend = 0.014) and organ meat (P-trend = 0.017) were associated with better HL in women. Higher intake of seafood as a whole (P-trend = 0.07) and of shellfish (P-trend = 0.097) tended to be associated with better HL in men. Consumption of meat is therefore associated with a better HL in women"
  • Preventing noise-induced hearing loss, tinnitus in soldiers - Science Daily, 9/6/12 - "Antioxidants, dietary supplements and high-tech brain imaging are among some of the novel strategies that may help detect, treat and even prevent noise-induced hearing loss and tinnitus among American troops ... Noise-induced hearing loss doesn't just impact a person's ability to hear; it can cause balance issues, make it difficult to sleep and communicate, and even raise the risk for heart disease by increasing a person's blood pressure, lipids and blood sugar ... Dr. Seidman will discuss the use of nutraceuticals, such as acetyl-l-carnitine, alpha lipoic acid and resveratrol ... a nutraceutical with a resveratrol-based component may possibly hold the potential to not only prevent, but reverse hearing loss in certain circumstances for soldiers. This research is based on animal models, but will soon be tested with humans" - See resveratrol products at Amazon.com.
  • Dietary Antioxidant Intake is Associated with the Prevalence but not Incidence of Age-Related Hearing Loss - J Nutr Health Aging. 2011;15(10):896-900 - "We aimed to examine the link between dietary and supplement intakes of antioxidants, and both the prevalence and 5-year incidence of measured hearing loss ... participants aged 50+ at baseline, examined during 1997-9 to 2002-4 ... Dietary data were collected in a semi-quantitative food frequency questionnaire ... each standard deviation (SD) increase in dietary vitamin E intake was associated with a 14% reduced likelihood of prevalent hearing loss, odds ratio, OR, 0.86 (95% confidence interval, CI, 0.78-0.98). Those in the highest quintile of dietary vitamin A intake had a 47% reduced risk of having moderate or greater hearing loss (>40 dB HL) compared to those in the lowest quintile of intake, multivariable-adjusted OR 0.53 (CI 0.30-0.92), P for trend = 0.04. However, dietary antioxidant intake was not associated with the 5-year incidence of hearing loss"
  • Listen up! Antioxidants may slash risk of hearing loss, says study - Nutra USA, 7/19/11 - "People with the highest average intakes of vitamin A had a 47 percent reduced risk of moderate or greater hearing loss, compared to people with the lowest average intakes ... In addition, increasing dietary vitamin E intakes were linked with a 14 percent reduction in hearing loss"
  • Dietary Intake of Cholesterol Is Positively and Use of Cholesterol-Lowering Medication Is Negatively Associated with Prevalent Age-Related Hearing Loss - J Nutr. 2011 May 25 - "After multivariable adjustment, the likelihood of prevalent hearing loss increased from the lowest (reference) to the highest quartile of dietary cholesterol intake (P-trend = 0.04). Among persons self-reporting statin use (n = 274), a 48% reduced odds of prevalent hearing loss was observed after multivariable adjustment [OR = 0.52 (95% CI = 0.29-0.93)]. Participants in the second and 3rd quartiles of dietary monounsaturated fat intake compared with those in the first quartile (reference) had a significantly reduced risk of hearing loss progression 5 y later [multivariable-adjusted OR = 0.39 (95% CI = 0.21-0.71)] and [OR = 0.51 (95% CI = 0.29-0.91)], respectively. Our results suggest that a diet high in cholesterol could have adverse influences on hearing, whereas treatment with statins and consumption of monounsaturated fats may have a beneficial influence"
  • Musical experience offsets some aging effects: Older musicians excel in memory and hearing speech in noise compared to non-musicians - Science Daily, 5/11/11 - "when compared to their non-musician counterparts -- musicians 45- to 65-years-old excel in auditory memory and the ability to hear speech in noisy environments ... Difficulty hearing speech in noise is among the most common complaints of older adults, but age-related hearing loss only partially accounts for this impediment that can lead to social isolation and depression ... It's well known that adults with virtually the same hearing profile can differ dramatically in their ability to hear speech in noise ... The musicians -- who began playing an instrument at age 9 or earlier and consistently played an instrument throughout their lives -- bested the non-musician group in all but visual working memory, where both groups showed nearly identical ability ... Music training "fine-tunes" the nervous system"
  • Age-related hearing loss and folate in the elderly - Science Daily, 12/1/10 - "The main finding of the study was that low serum levels of folic acid were significantly associated with high-frequency hearing loss in the elderly" - See folic acid at Amazon.com.
  • Age-related hearing loss, vitamin B12, and folate in the elderly - Otolaryngol Head Neck Surg. 2010 Dec;143(6):826-30 - "Spearman's correlation revealed that low folate (correlation coefficient = -0.27, P = 0.01) and cyanocobalamin (correlation coefficient = -0.35, P = 0.02) were significantly associated with increasing hearing threshold in the high frequencies. After adjusting for age, serum folate (correlation coefficient = -0.01, P = 0.01) was significant, while vitamin B12 (correlation coefficient = -0.01, P = 0.74) was not" - See folic acid at Amazon.com.
  • Dietary Glycemic Load Is a Predictor of Age-Related Hearing Loss in Older Adults - J Nutr. 2010 Oct 6 - "Participants in the highest quartile of mean dietary GL intake compared with those in the lowest quartile had a 76% greater risk of developing incident hearing loss (P-trend = 0.04). Higher carbohydrate and sugar intakes were associated with incident hearing loss (P-trend = 0.03 and P-trend = 0.05, respectively). In summary, a high-GL diet was a predictor of incident hearing loss, as was higher intake of total carbohydrate. Hence, high postprandial glycemia might be a potential underlying biological mechanism in the development of age-related hearing loss"
  • Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss - Am J Clin Nutr. 2010 Jun 9 - "There was an inverse association between total n-3 PUFA intake and prevalent hearing loss [odds ratio (OR) per SD increase in energy-adjusted n-3 PUFAs: 0.89; 95% CI: 0.81, 0.99]. There was an inverse association between long-chain n-3 PUFAs and incident hearing loss (OR per SD increase in long-chain n-3 PUFAs: 0.76; 95% CI: 0.60, 0.97). Participants who had >/=2 servings of fish/wk compared with participants who had <1 serving of fish/wk had a significantly reduced risk (42%) of developing presbycusis at follow-up (multivariate-adjusted OR: 0.58; 95% CI: 0.35, 0.95). There was an association between consumption of >/=1 to <2 servings/wk of fish and a reduced risk of a progression of hearing loss (OR: 0.53; 95% CI: 0.32, 0.88). CONCLUSIONS: There was an inverse association between higher intakes of long-chain n-3 PUFAs and regular weekly consumption of fish and hearing loss. Dietary intervention with n-3 PUFAs could prevent or delay the development of age-related hearing loss" - [Nutra USA] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Folate may prevent hearing loss in men - Nutra USA, 10/7/09 - "men over the age of 60 with high folate intake from foods and supplements had a 20 per cent decrease in risk of developing hearing loss" - See folic acid products at Amazon.com.
  • Can A Dietary Supplement Stave Off Hearing Loss? - Science Daily, 2/12/09 - "temporary noise-induced hearing loss – the hearing loss you might feel immediately after attending a loud concert but that goes away in a day or two – can be prevented in guinea pigs by a combination of the antioxidants beta-carotene, vitamin C, and vitamin E and the mineral magnesium, when administered before exposure to a loud sound ... In a second study conducted with colleagues at Washington University, the researchers demonstrated that permanent noise-induced hearing loss can also be prevented in mice through the combination of the same nutrients administered before exposure to a loud noise"
  • Can Vitamins And Minerals Prevent Hearing Loss? - Science Daily, 11/10/08 - "The combination of vitamins A, C and E, plus magnesium, is given in pill form to patients who are participating in the research. Developed at the U-M Kresge Hearing Research Institute, the medication, called AuraQuell, is designed to be taken before a person is exposed to loud noises. In earlier testing at U-M on guinea pigs, the combination of the four micronutrients blocked about 80 percent of the noise-induced hearing impairment"
  • Vitamin E and vitamin C in the treatment of idiopathic sudden sensorineural hearing loss - Acta Otolaryngol. 2007 Aug 22;:1-6 - "The hearing gain after therapy was 29.4 dB and the improvement rate was 63.3% in the study group, compared with 18.5 dB and 44.0% in the control group. Significant improvement was seen in the hearing gain and recovery rate in the study group"
  • Nutrients Against Noise? - Dr. Weil, 5/1/07
  • Nutrient Combo May Curb Hearing Loss - WebMD, 3/30/07 - "The guinea pigs that got the combination treatment of magnesium and vitamins A, C, and E had the least amount of noise-induced hearing loss and ear damage"
  • Folic Acid May Slow Hearing Loss - WebMD, 1/2/07 - "Half the study participants got strong folic acid supplements -- 800 micrograms per day, about twice what one would get in a multivitamin pill ... After three years, those who got folic acid pills had less low-frequency hearing loss than did placebo recipients"
  • Can You Stop Hearing Loss? - Dr. Weil, 11/26/04
  • Vitamin E Helps People with Sudden Hearing Loss - Healthwell Exchange Daily News, 10/2/03 - "one group received vitamin E, 600 IU two times per day, while the other did not. Treatment was considered successful when hearing improved by 75% or more ... At follow-up examinations, successful treatment was noted in 76% of those receiving vitamin E and 56% of those not receiving vitamin E"
  • Cod Liver Oil Fights Ear Infections - WebMD, 7/15/02
  • Low High-density Lipoprotein Cholesterol Levels Linked To Hearing Loss In Men - Doctor's Guide, 10/23/00 - "The two groups showed no difference in hearing when stratified based on total cholesterol and total triglyceride levels. However, when men were stratified based on their HDL cholesterol concentration, hearing levels at 2000 Hz and 4000 Hz in the high-level group were significantly better than those with low concentrations of this lipid ... The authors suggest that low serum concentration of HDL cholesterol is associated with hearing loss."
  • Local Steroids May Be Effective In Treating Sudden Hearing Loss - Doctor's Guide, 9/30/99
  • Antioxidant-Enhancing Drug Partly Reduces Noise-Induced Hearing Loss - Doctor's Guide, 9/12/97 - "the researchers showed the stress of loud noises causes an increase in free radicals in the inner ear, which can damage or kill sensory cells. To defend themselves, sensory cells express a rush of glutathione, an antioxidant that absorbs free radicals. R-PIA was found to increase the activity of glutathione, thus providing enhanced protection from free-radical damage."

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