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Anti-aging Research > Lactobacillus Acidophilus
Lactobacillus Acidophilus & Other Probiotics
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News & Research:
-
'Good'
bacteria to tackle depression - Science Daily, 6/9/22 -
"All participants were inpatients at the University
Psychiatric Clinics Basel (UPK) and were given a probiotic (21 subjects) or a
placebo (26 subjects) for 31 days, in addition to antidepressants ... although
depressive symptoms decreased in all participants thanks to the general
antidepressant treatment, there was a greater improvement in the subjects in the
probiotic group than in the placebo group ... Another interesting effect of
taking probiotics was seen in relation to brain activity when viewing neutral or
fearful faces. The researchers investigated this effect using functional
magnetic resonance imaging (fMRI). In patients with depression, certain brain
regions for emotional processing behave differently than in individuals with
good mental health. After four weeks of probiotics, this brain activity
normalized in the probiotic group but not in the placebo group ... Although the
microbiome-gut-brain axis has been the subject of research for a number of
years, the exact mechanisms are yet to be fully clarified ... This was another
reason why the researchers believed it was important to use a wide range of
bacteria in the form of probiotics, such as formulations already available on
the market" - See probiotic supplements at Amazon.com.
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Antibiotics wreak havoc on athletic performance - Science Daily, 6/1/22 -
"by killing essential gut bacteria, antibiotics ravage athletes' motivation and
endurance ... when wheel running in the athletic mice was reduced by 21 percent,
researchers were certain the microbiome damage was responsible. In addition, the
high runner mice did not recover their running behavior even 12 days after the
antibiotic treatment stopped"
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Can Fecal Transplants Help
Reverse Aging? - Medscape, 5/12/22 - "Transplanting
fecal microbiota from young mice into older mice can reverse signs of aging in
the gut, brain, and eyes, a team of scientists from the United Kingdom has
found. Conversely, transplanting microbiota from old mice to young mice has the
opposite effect ... Age-related changes in diversity, composition, and function
of the gut microbiota are associated with low-grade systemic inflammation,
declining tissue function, and increased susceptibility to age-related chronic
diseases ... Targeting the gut-brain axis in aging, by modification of microbial
composition to modulate immune and metabolic pathways, may therefore be a
potential avenue for therapeutic approaches to age-associated inflammatory and
functional decline" - See probiotic supplements at Amazon.com.
-
Gut Bacteria Linked to
Stroke Severity, Risk - Medscape, 5/6/22 - "Gut
microbiota have been implicated in dementia risk, cardiovascular disease, and
multiple sclerosis relapse. Prior research has also pointed to a possible link
between gut bacteria and stroke ... A potential future development of our study
would be to investigate the effects of altering the gut microbiota of patients
at high risk of stroke by giving them probiotics, prebiotics, or performing
fecal matter transplants and measuring whether their risk of stroke is reduced
... The exact mechanisms by which gut bacteria might influence neurologic
conditions such as stroke are uncertain, but one possibility is that they could
cause changes to the immune system" - See
probiotic supplements at Amazon.com and
prebiotic supplements at
Amazon.com.
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Probiotic Improves
Symptoms of Irritable Bowel Syndrome - Medscape, 5/9/22 -
"After the 30-day treatment period with B longum 35624,
a significant decrease in IBS severity was observed, compared with baseline. The
IBS-SSS score went from 303 to 208 (P < .001). More than half of the patients
(57%) experienced an overall decrease in their symptoms. The rate of severe
symptoms decreased from 46.6% to 20%; moderate symptoms decreased from 48.1% to
36.1%; mild symptoms increased from 4.7% to 35.2%; and 8.7% of patients were in
remission after the treatment vs 0.9% before. A significant improvement in
disease severity (more than a 50-point decrease in the IBS-SSS score) was
observed in 65.7% of patients, regardless of the IBS subtype ... After 30 days
of treatment, a significant improvement in quality of life was noted in the
patients (IBS-QOL score 68.8 vs 60.2, P < .001), and more than 6 out of 10 (63%)
were satisfied with the treatment" - See
probiotic supplements at Amazon.com.
-
Targeting the Microbiota
May Help Manage Type 2 Diabetes - Medscape, 4/20/22 -
"Daily oral supplementation with live or pasteurized A
muciniphila at the dose of 1010 bacteria/day or more for 3 months was safe and
well tolerated among patients who were overweight or with obesity, as well as
people with insulin resistance who presented with metabolic syndrome. Compared
with placebo, pasteurized A muciniphila improved insulin sensitivity and lowered
serum insulin and plasma total cholesterol levels, and it was associated with a
reduction in body fat, hip circumference, and weight (−2.27 kg). Blood markers
of inflammation and liver dysfunction were improved" - Note: The
only place that
I could find that sells it is sold out. They want $105 for a 30 day supply.
-
Oral Probiotic Could
Improve HPV Clearance - Medscape, 4/20/22 - "At a
median follow-up of 12 months, HPV-related cytological anomalies cleared in
60.5% of the probiotic group vs 41.3% of the control group (P = .05) ... HPV
cleared in 15.3% of the probiotic arm vs 9.3% of the control group (P = .34)"
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Scientists develop coated probiotics that could be effectively delivered into
the human gut - Science Daily, 3/25/22 - "In the
NTU-study, the probiotics, gut-friendly Lacticaseibacillus bacteria, are
spray-coated with alginate, a carbohydrate derived from brown algae, protecting
them from the harsh acidic conditions in the stomach" - Note: But they've
been claiming that for decades.
-
Healthy
gut microbiome improves success of cancer treatment - Science Daily, 2/28/22
- "The largest study to date has confirmed the link
between the gut microbiome and the response to cancer immunotherapy therapy for
melanoma ... The presence of three types of bacteria (Bifidobacterium
pseudocatenulatum, Roseburia spp. and Akkermansia muciniphila) seem to be
associated with a better immune response. An additional finding was that the
microbiome itself is strongly influenced by factors including patient
constitution, use of proton pump inhibitors and diet that should be considered
in future longitudinal studies" - See probiotic supplements at Amazon.com.
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Scientists characterize the imbalanced gut bacteria of patients with myocardial
infarction, angina and heart failure - Science Daily, 2/18/22 -
"However, the early microbiome changes persisted in
patients with heart disease who in addition showed specific heart disease
related alterations in the composition and function of the gut microbiome. Both
at the early dysmetabolic stage and at the later stages of diagnosed heart
disease, the diseased microbiome was characterized by a loss of bacterial cells
and bacterial competences. In addition, the patients showed a shift towards
fewer types of bacteria known to produce health promoting compounds like short
chain fatty acids and more bacteria types producing unhealthy compounds from the
metabolism of certain dietary amino acids, choline and L-carnitine. Analyses of
the blood compounds mirrored the imbalance of the gut microbiome ...
Intervention in both humans and rodents have shown that an imbalanced gut
microbiome at various stages of heart disease development can be modified and
partly restored by eating a more plant-based and energy-controlled diet,
avoidance of smoking and compliance with daily exercise" - See
probiotic supplements at Amazon.com.
-
Gut Bacteria Linked With
Long COVID - Medscape, 1/25/22 - "the researchers
enrolled 106 patients with COVID-19 from February to August 2020, and compared
them with people who did not have COVID, recruited in 2019. The severity of
COVID in the enrolled patients was mostly mild to moderate ... At 3 months, 86
of the COVID patients had post–acute COVID-19 syndrome (PACS) — defined as at
least one persistent, otherwise unexplained symptom 4 weeks after clearance of
the virus. And 81 patients had PACS at 6 months, most commonly fatigue, poor
memory, hair loss, anxiety, and trouble sleeping ... broadly, the diversity of
the types of bacteria, and the abundance of these bacteria, were significantly
lower at 6 months for those with PACS, compared with those without PACS and with
controls (P < .05 and P < .0001, respectively). Among those with PACS, 28
bacteria species were diminished and 14 were enriched, both at baseline and
follow-up. Those patients who had COVID but not PACS showed just 25 alterations
of bacteria species at the time of hospital admission, and they all normalized
by 6 months ... Having respiratory symptoms at 6 months was linked with higher
levels of opportunistic pathogens such as Streptococcus anginosus and S.
vestibularis. Neuropsychiatric symptoms and fatigue were associated with
nosocomial pathogens that are linked to opportunistic infections, such as
Clostridium innocuum and Actinomyces naeslundii ... Bacteria known for producing
butyrate, a beneficial fatty acid, were significantly depleted in those patients
with hair loss. And certain of these bacteria, including Bifidobacterium
pseudocatenulatum and Faecalibacterium prausnitzii, had the largest inverse
correlations with PACS at 6 months (P < .05), the researchers found ... Her
group is conducting trials to look at how modulating the microbiome might
prevent long COVID and boost antibodies after vaccination in high-risk people
... Gut microbiota influences the health of the host ... It provides crucial
benefits in the form of immune system development, prevention of infections,
nutrient acquisition, and brain and nervous system functionality. Considering
the millions of people infected during the ongoing pandemic, our findings are a
strong impetus for consideration of microbiota modulation to facilitate timely
recovery and reduce the burden of post–acute COVID-19 syndrome" - See
probiotic supplements at Amazon.com.
-
Could Probiotics Reduce
'Chemo Brain' in Breast Cancer Patients? - Medscape, 1/18/22 - "The
finding that probiotic treatment given alongside chemotherapy is sufficient to,
in part, protect against memory disturbances in these patients suggests that
there may be some neuroprotection conferred by the probiotic treatment" -
See probiotic supplements at Amazon.com.
-
Common
drugs affect our gut microbiome differently, with good and bad impacts on health
- Science Daily, 12/9/21 - "In the colon of people who
take gastric acid medication, we found relatively high levels of bacteria that
are normally only present in the oral cavity. Stomach acid usually kills
bacteria from the oral cavity that try to escape to the gut where they do not
belong. But this is not the case when you use these gastric acid inhibitors. The
observation we have made is important because the presence of oral bacteria in
the colon is associated with an increased risk of developing some types of colon
cancer"
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The
impact of drugs on gut microbes is greater than we thought - Science Daily,
12/8/21 - "We know that the microbiome can reflect the
status of a patient's health and provide a range of biomarkers to assess the
severity of diseases. What is often overlooked, however, is that the medication
used to treat a disease also affects the state of the microbiome ... The
researchers are hopeful that these results can provide knowledge that could
potentially help in drug repurposing as well as in planning individualised
treatment and prevention strategies"
-
Probiotics improve nausea and vomiting in pregnancy - Science Daily, 12/4/21
- "Nausea, vomiting and constipation during
pregnancy can significantly diminish the quality of patients' lives. Once nausea
and vomiting during pregnancy progress, they can become difficult to control,
and sometimes the patient even needs to be hospitalized ... During pregnancy,
hormones like estrogen and progesterone increase, bringing about many physical
changes. These increases can also change the gut microbiome, which likely
affects the digestive system functions and causes unwanted symptoms like nausea,
vomiting and constipation ... A total of 32 participants took a probiotic
capsule twice a day for six days and then took two days off. They then repeated
the cycle ... The probiotics were available over-the-counter and mainly
contained Lactobacillus., a type of good bacteria. Each capsule contained
approximately 10 billion live cultures at the time of manufacture ... taking the
probiotic significantly reduced nausea and vomiting. Nausea hours (the number of
hours participants felt nauseous) were reduced by 16%, and the number of times
they vomited was reduced by 33%. Probiotic intake also significantly improved
symptoms related to quality of life, such as fatigue, poor appetite and
difficulty maintaining normal social activities, as scored by questionnaires ...
Probiotics were also found to reduce constipation significantly ... Another
finding was that vitamin E levels increased after taking probiotics. Higher
levels of vitamin E were associated with low vomiting scores"
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Gut Health 'Vitally Important' for Mental Health - Medscape, 9/21/21 -
"A meta-analysis of 59 studies, encompassing roughly
2600 patients with psychiatric conditions, showed a decrease in microbial
richness in patients with psychiatric conditions vs controls."
-
Microbes turn back the clock as research discovers their potential to reverse
aging in the brain - Science Daily, 8/9/21 - "There
is a growing appreciation of the importance of the microbes in the gut on all
aspects of physiology and medicine. In this latest mouse study the authors show
that by transplanting microbes from young into old animals they could rejuvenate
aspects of brain and immune function. Prof John F. Cryan, says "Previous
research published by the APC and other groups internationally has shown that
the gut microbiome plays a key role in aging and the aging process. This new
research is a potential game changer , as we have established that the
microbiome can be harnessed to reverse age-related brain deterioration. We also
see evidence of improved learning ability and cognitive function." Although very
exciting Cryan cautions that "it is still early days and much more work is
needed to see how these findings could be translated in humans."" - See
probiotic supplements at Amazon.com
and
iHerb.
-
Characterization of the
Gut-Liver-Muscle Axis in Cirrhotic Patients With Sarcopenia - Medscape,
7/6/21 - "Alterations in the gut-liver-muscle axis are
associated with sarcopenia in patients with cirrhosis. Detrimental but also
compensatory functions are involved in this complex network" - See
probiotic supplements at Amazon.com
and
iHerb.
-
Probiotic Supplementation
Regulates Newborn Immune System - Medscape, 6/28/21 -
"Supplementing breastfed infants with bifidobacteria
promotes development of a well-regulated immune system, theoretically reducing
risk of immune-mediated conditions like allergies and asthma ... These findings
support the importance of early gut colonization with beneficial microbes, an
event that may affect the immune system throughout life"
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The Probiotic Strain H. alvei
HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric
Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind
Placebo-Controlled Study - Nutrients 2021 -
"Subjects of the HA group received two capsules per day providing 100 billion
bacteria per day and subjects in the Placebo (P) group received two placebo
capsules ... A 12-week treatment with the probiotic strain H. alvei HA4597®
significantly improves weight loss, feeling of fullness and reduction of hip
circumference in overweight subjects following moderate hypocaloric diet. These
data support the use of H. alvei HA4597® in the global management of excess
weight" - [Nutra
USA] - Note: Here's the
targedys.com website. I don't see where it's for sale anywhere.
-
Fecal Transplantation Safe
but Ineffective in PsA Trial - Medscape, 5/7/21 -
"The first clinical trial of fecal microbiota transplantation in patients with
psoriatic arthritis has found the procedure to be as safe as a sham procedure,
but it didn't show any effectiveness in decreasing PsA symptoms over 6 months"
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The Gut Microbiota in
Osteoarthritis - Medscape, 3/11/21 - "Osteoarthritis
(OA) is one of the most frequent musculoskeletal diseases characterized by
degeneration of articular cartilage, subchondral bone remodeling, and synovial
membrane inflammation, which is a leading cause of global disability, morbidity,
and decreased quality of life ... Gut microbiota is responsible for a series of
metabolic, immunological, and structural and neurological functions, potentially
elucidating the heterogeneity of OA phenotypes and individual features. In this
narrative review, we summarized research evidence supporting the hypothesis of a
"gut-joint axis" and the interaction between gut microbiota and the OA-relevant
factors, including age, gender, genetics, metabolism, central nervous system,
and joint injury, elucidating the underlying mechanisms of this intricate
interaction. In the context, we also speculated the promising manipulation of
gut microbiota in OA management, such as exercise and fecal microbiota
transplantation (FMT), highlighting the clinical values of gut microbiota.
Additionally, future research directions, such as more convincing studies by the
interventions of gut microbiota, the gene regulation of host contributing to or
attributed to the specific phenotypes of gut microbiota related to OA, and the
relevance of distinct cell subgroups to gut microbiota, are expected. Moreover,
gut microbiota is also the potential biomarker related to inflammation and gut
dysbiosis that is able to predict OA progression and monitor the efficacy of
therapeutic intervention"
-
How Do Gut Bacteria Affect
COVID-19 Severity? - Medscape, 2/4/21 - "The gut,
which regulates immune response, is one of the largest and most essential organs
in the body. COVID-19 patients have been found to have poorer gut microbiome
compositions compared with those without the disease ... Dysbiosis — abnormal
gut microbiome — may account for long-term COVID-19 symptoms. In studies,
elderly patients and those with chronic conditions were more likely to have
dysbiosis, which might explain their increased risk for severe disease ...
COVID-19 is not just a lung disease. Anywhere from 30% to 40% have gut
manifestations too. Stool samples are now being used to test for COVID-19 ...
The best way to promote good gut bacteria and reduce inflammation is to eat a
healthy diet, with less processed food and food additives, and more fiber.
Exercise is also important ... Select probiotics carefully; they are not all
created equal"
-
Poor
gut health connected to severe COVID-19, new review shows - Science Daily,
1/12/21 - "The "western diet" that's common in these
countries is low in fiber, and "a fiber-deficient diet is one of the main causes
of altered gut microbiomes," he said, "and such gut microbiome dysbiosis leads
to chronic diseases." ... The pathogenesis of COVID-19 is still not fully
understood. If future studies do show that gut health affects COVID-19
prognosis, Kim argued, then clinicians and researchers should exploit that
connection for better strategies aimed at preventing and managing the disease.
Eating more fiber, he said, may lower a person's risk of serious disease. And
fecal microbiota transplantation might be a treatment worth considering for
patients with the worst cases of COVID-19"
-
Link
between gut microbes, diet and illnesses revealed - Science Daily, 1/11/21 -
"The researchers defined a "healthy" diet as one that
contained a mix of foods associated with a lower risk of chronic disease. They
found that trial subjects who ate such a diet, or one rich in plants, were more
likely to have high levels of specific 'good' gut microbes which are associated
with a low risk of common illnesses. The researchers also found microbiome-based
biomarkers of obesity as well as markers for cardiovascular disease and impaired
glucose tolerance, which are key risk factors for COVID. These findings can be
used to help create personalized eating plans designed specifically to improve
one's health" - See probiotic supplements at Amazon.com.
-
Scientists reveal how gut microbes can influence bone strength in mice -
Science Daily, 1/12/21 - "The findings suggest that
treatments which alter the gut microbiome could help improve bone structure or
treat conditions that weaken bones, such as osteoporosis"
-
Gut
microbe may promote breast cancers - Science Daily, 1/6/21 -
"Our study suggests another risk factor, which is
the microbiome. If your microbiome is perturbed, or if you harbor toxigenic
microbes with oncogenic function, that could be considered an additional risk
factor for breast cancer ... First, they performed a meta-analysis of clinical
data looking at published studies comparing microbial composition among benign
and malignant breast tumors and nipple aspirate fluids of breast cancer
survivors and healthy volunteers. B. fragilis was consistently detected in all
breast tissue samples as well as the nipple fluids of cancer survivors ... In
the lab, the team gave the ETBF bacteria by mouth to a group of mice. First, it
colonized the gut. Then, within three weeks, the mouse mammary tissue had
observable changes usually present in ductal hyperplasia, a precancerous
condition. In additional tests, investigators found that hyperplasia-like
symptoms also appeared within two to three weeks of injecting ETBF bacteria
directly to the teats of mice, and that cells exposed to the toxin always
exhibited more rapid tumor progression and developed more aggressive tumors than
cells not exposed to the toxin"
-
Link
between dietary fiber and depression partially explained by gut-brain
interactions - Science Daily, 1/6/21 - "The
study confirmed an inverse association between dietary-fiber intake and
depression in premenopausal women after adjusting for other variables, but no
significant difference was documented in postmenopausal women. Research has
suggested that estrogen depletion may play a role in explaining why
postmenopausal women don't benefit as much from increased dietary fiber, because
estrogen affects the balance of gut microorganisms found in premenopausal and
postmenopausal women. The link between dietary fiber and depression may be
partially explained by gut-brain interactions, because it is theorized that
changes in gut-microbiota composition may affect neurotransmission. Fiber
improves the richness and diversity of gut microbiota." - See
probiotic supplements at Amazon.com.
-
Gut
microbiota plays a role in brain function and mood regulation - Science
Daily, 12/11/20 - "Using animal models, scientists
recently discovered that a change to the gut microbiota brought about by chronic
stress can lead to depressive-like behaviors, in particular by causing a
reduction in lipid metabolites (small molecules resulting from metabolism) in
the blood and the brain." - See probiotic supplements at Amazon.com
and
iHerb.
-
Connection between gut bacteria and vitamin D levels - Science Daily,
11/30/20 - "In addition to discovering a link
between active vitamin D and overall microbiome diversity, the researchers also
noted that 12 particular types of bacteria appeared more often in the gut
microbiomes of men with lots of active vitamin D. Most of those 12 bacteria
produce butyrate, a beneficial fatty acid that helps maintain gut lining health"
- See vitamin D at Amazon.com and
vitamin D
at iHerb.
-
Link
between Alzheimer's disease and gut microbiota is confirmed - Science Daily,
11/16/20 - "A team from the University of Geneva (UNIGE)
and the University Hospitals of Geneva (HUG) in Switzerland, together with
Italian colleagues from the National Research and Care Center for Alzheimer's
and Psychiatric Diseases Fatebenefratelli in Brescia, University of Naples and
the IRCCS SDN Research Center in Naples, confirm the correlation, in humans,
between an imbalance in the gut microbiota and the development of amyloid
plaques in the brain, which are at the origin of the neurodegenerative disorders
characteristic of Alzheimer's disease ... This discovery paves the way for
potentially highly innovative protective strategies -- through the
administration of a bacterial cocktail, for example, or of pre-biotics to feed
the "good" bacteria in our intestine" - See
prebiotic supplements at
Amazon.com and
iHerb and probiotic supplements at Amazon.com
and
iHerb.
-
Probiotic Blend May Help
Patients With GI Symptoms - Medscape, 10/28/20 -
"evaluated the safety and efficacy of a five-strain probiotic blend - comprised
of Bl-04, Bi-07, HN019, NCFM, and Lpc-37 - in people with functional GI
disturbances ... In the open-label, multicenter study, all 188 adult
participants - mean age, 44.1 years; 72.3% female - demonstrated symptoms of
functional GI disturbances. Each received an oral capsule of the probiotic blend
once daily for 30 days ... By day 30, 85.1% of patients had achieved the primary
end point and indicated a positive response when asked about their overall GI
well-being. All of the improvements reported at day 30 were generally observed
at day 14 as well"
-
Probiotics
Promising for Parkinson's Constipation - Medscape, 10/22/20
- "randomized 72 patients (mean
age, about 70; about 65% men) to a multi-strain probiotics
capsule or placebo for four weeks. Each probiotic capsule
contained 10 billion colony forming units of eight different
commercially-available bacterial strains: Lactobacillus
acidophilus, L. reuteri, L. gasseri, L. rhamnosus,
Bifidobacterium bifidum, B. longum, Enterococcus faecalis, and
E. faecium. The placebo group received capsules containing
maltodextrin ... spontaneous bowel movements (SBMs) per week ...
SBMs increased by a mean of one per week after probiotics
treatment, and decreased by 0.3 per week in the placebo group.
After correction for multiple comparisons, significant
improvements with probiotics were also seen for secondary
outcomes, including stool consistency and quality of life
related to constipation. A trend for reduced laxative usage was
also seen ... Satisfaction was reported by 65.6% of intervention
group participants versus 21.6% in the placebo group"
-
Gut
microbiome plays important role in sleep regulation - Science Daily, 9/23/20
- "the gut microbiome plays a major role in sleep
regulation. This ultimately could translate into treatments that target the gut
microbiome in humans with OSA ... The study exposed male mice to either room air
or intermittent hypoxia -- a condition in which the body doesn't get enough
oxygen -- designed to mimic OSA. After six weeks, researchers collected fecal
material from all of the rodents. A third group of mice was divided up and given
either a fecal transplant from the mice breathing room air or those exposed to
intermittent hypoxia. The transplanted mice underwent sleep recordings for three
consecutive days. Researchers found the mice who received transplants from the
intermittent hypoxia group slept longer and slept more often during their normal
period of wakefulness, suggesting increased sleepiness"
-
Gut
microbes could unlock the secret to healthy aging - Science Daily, 8/27/20 -
"Bacteria and other microorganisms in the digestive
tract are linked with dozens of health conditions including high blood pressure,
high blood lipids, and body mass index (BMI) according to research presented
today at ESC Congress 2020 ... The researchers found that higher levels of
eleven bacteria (estimated from genetic data) were associated with a total of 28
health and disease outcomes. These included chronic obstructive pulmonary
disease (COPD), atopy (a genetic tendency to develop allergic diseases like
asthma and eczema), frequency of alcohol intake, high blood pressure, high blood
lipids, and BMI ... To take one example, higher levels of the genus Ruminococcus
were linked with increased risk of high blood pressure ... Regarding alcohol
consumption, Dr. Groot said: "What we eat and drink is connected to microbiome
content, so we studied the links with meat, caffeine, and alcohol. We observed a
relationship between raised levels of Methanobacterium and drinking alcohol more
often. It is important to stress that this is an association, not a causal
relation, and more research is needed.""
-
Supplement Plus Probiotic
May Improve Depressive Symptoms - Medscape, 8/12/20 -
"randomly assigned 90 patients with subthreshold or
mild-to-moderate depression to receive either SAMe plus L. plantarum HEAL9 or
placebo for 6 weeks and found significant reductions in depression, anxiety, and
cognitive symptoms as early as 2 weeks following treatment initiation ... The
effect of this novel product is independent from the severity of the symptoms,
unlike traditional antidepressants available on the market that have minimal
benefits for subthreshold or mild-to-moderate symptoms ... Extensive research
has also shed light on the role of microbiota in patients with depressive
disorder, suggesting a role for probiotic supplementation. A probiotic called L.
plantarum 299v has been found to have a significant effect on stress markers,
such as cortisol levels ... At 2 weeks, participants showed significant
reductions in the cognitive and anxiety subdomains of the Z-SDS" - See
probiotic supplements at Amazon.com
and
iHerb and SAM-e at Amazon.com and
iHerb.
-
Probiotics Reduce Allergic
Rhinitis in Children and Adults - Medscape, 6/18/20 -
"The 115 infants in the probiotic group received five
drops of L reuteri daily from the age of 4 weeks to 12 weeks. "The drops were
put on the mother's nipple, directly to the child's mouth," she explained ...
The 201 children in the control group were breast-fed without any supplements.
All children were followed by the same pediatrician until they were 9 years of
age ... Children in the probiotic group were three times less likely to develop
allergic rhinitis than those in the control group"
-
Improved gut microbiota with cholesterol-lowering medication - Science
Daily, 6/15/20 - "The positive and hitherto unknown
effect of statins identified by the researchers was that the proportion of
individuals with Bact2 decreased in the group given statin therapy, resulting in
a more normal gut microbiota"
-
Gut
microbiome influences ALS outcomes - Science Daily, 5/13/20 -
"mice with a common ALS genetic mutation, changing the
gut microbiome using antibiotics or fecal transplants could prevent or improve
disease symptoms ... he findings provide a potential explanation for why only
some individuals carrying the mutation develop ALS. They also point to a
possible therapeutic approach based on the microbiome ... The gut-brain axis has
been implicated in a range of neurological conditions, including Parkinson's
disease and Alzheimer's disease. Our results add weight to the importance of
this connection"
-
Probiotic Reduces Crying
Time in Colicky Infants - Medscape, 12/4/19 - "80%
of BB-12 recipients showed a ≥50% reduction in crying duration after 28 days,
compared with 31.5% of those in the placebo group (P < .0001"
-
Increased use of antibiotics may predispose to Parkinson's
disease - Science Daily, 11/22/19 -
"The strongest associations were found for broad spectrum
antibiotics and those that act against against anaerobic
bacteria and fungi. The timing of antibiotic exposure also
seemed to matter ... The study suggests that excessive use of
certain antibiotics can predispose to Parkinson's disease with a
delay of up to 10 to 15 years. This connection may be explained
by their disruptive effects on the gut microbial ecosystem"
-
Gut microbiota imbalance promotes the onset of colorectal cancer
- Science Daily, 11/18/19 - "an
imbalance in the gut microbiota, also known as "dysbiosis,"
promotes the onset of colorectal cancer ... transplanting fecal
flora from patients with colon cancer into mice caused lesions
and epigenetic changes characteristic of the development of a
malignant tumor"
-
Where does Parkinson's disease start? In the brain or gut? Or
both? - Science Daily, 11/7/19 - "It
may be possible to prevent the 'gut-first' type of PD through
interventions targeting the gut, such as probiotics, fecal
transplants, and anti-inflammatory treatments. However, these
strategies might not work with respect to treating and
preventing the brain-first type. Thus, a personalized treatment
strategy will be required, and we need to be able to identify
these subtypes of PD in the individual patient" - See
probiotic supplements at Amazon.com.
-
Gut
bacteria is key factor in childhood obesity - Science Daily, 10/30/19 -
"The medical community used to think that obesity was a
result of consuming too many calories. However, a series of studies over the
past decade has confirmed that the microbes living in our gut are not only
associated with obesity but also are one of the causes" - See
probiotic supplements at Amazon.com.
-
Could More Coffee Bring a Healthier Microbiome? - WebMD, 10/28/19 -
"Overall, the 34 participants who drank two or more cups
of coffee daily throughout the previous year exhibited better gut microbiome
profiles than those who consumed less or no coffee ... Heavy coffee drinkers'
bacterial species were more abundant and more evenly distributed throughout the
large intestine, richer in anti-inflammatory properties, and considerably less
likely to include Erysipelatoclostridium, a type of bacteria linked to metabolic
abnormalities and obesity ... coffee's polyphenols and other antioxidants,
compounds naturally found in plant foods, are likely what's providing a
healthier microbiome"
-
Gut
instincts: Researchers discover first clues on how gut health influences brain
health - Science Daily, 101/23/19 - "Over the
last two decades, scientists have observed a clear link between autoimmune
disorders and a variety of psychiatric conditions. For example, people with
autoimmune disorders such as inflammatory bowel disease (IBD), psoriasis and
multiple sclerosis may also have depleted gut microbiota and experience anxiety,
depression and mood disorders. Genetic risks for autoimmune disorders and
psychiatric disorders also appear to be closely related. But precisely how gut
health affects brain health has been unknown ... The gut-brain axis impacts
every single human being, every day of their lives ... We are beginning to
understand more about how the gut influences diseases as diverse as autism,
Parkinson's disease, post-traumatic stress disorder and depression. Our study
provides a new piece of understanding of how the mechanisms operate"
-
Probiotic pills could bring an end to malnutrition, says billionaire
philanthropist Bill Gates - Telegraph, 10/7/19 - "He
argues that better scientific understanding of the human microbiome –
specifically the microorganisms which inhabit the gut – will enable the
development of “smartly engineered” probiotic pills which will help us to retain
more of the nutrients in the foods we eat"
-
Why probiotics could hold the key to solving malnutrition – the world’s
worst health problem - Bill Gates, 10/7/19 -
"Saving these children isn’t as simple as making sure they have enough food
to eat. Stunting can happen even if you’re getting enough calories ... there
are a few less intuitive causes of stunting. A deeper understanding of one
of those reasons – the microbiome of the human body – is why I believe we’re
going to solve malnutrition within 20 years ... Another intervention could
be what’s called “microbiota directed complementary foods.” Think of them as
being like fertiliser for the microbiome. Eating them encourages healthy
bacteria – the ones that help digest food and protect us from infection – to
flourish." - See probiotic supplements at Amazon.com
and
prebiotic supplements at Amazon.com
 .
-
Molecule links weight gain to gut bacteria - Science Daily, 9/27/19 -
"Their findings could have far-ranging implications for
obesity in affluent countries and malnutrition in impoverished countries ... In
the study, published this week by Science, Dr. Lora Hooper and her research team
found that the commensal, or good, bacteria that live in the guts of mammals
program the metabolic rhythms that govern the body's absorption of dietary fat
... Most mice on that diet become obese. To our surprise, those that had no
HDAC3 in their intestinal lining were able to eat a high fat, high sugar diet
and stay lean ... disrupting the interactions between the microbiota and the
body's clock could make us more likely to become obese. These disruptions happen
frequently in modern life when we take antibiotics, work overnight shifts, or
travel internationally. But we think that our findings might eventually lead to
new treatments for obesity -- and possibly malnutrition -- by altering the
bacteria in our guts"
-
Abnormal gut bugs tied to worse cognitive performance in vets with PTSD and
cirrhosis - Science Daily, 9/12/19 - "A study
involving military veterans with PTSD and cirrhosis of the liver points to an
abnormal mix of bacteria in the intestines as a possible driver of poor
cognitive performance -- and as a potential target for therapy ... the findings
add to the substantial evidence linking gut health and brain function ... Those
with PTSD had microbiota that were less diverse, meaning they had fewer types of
bacteria overall ... These veterans, along with the relative lack of diversity
in their gut, tended to have more potentially harmful types of bacteria, such as
Enterococcus and Escherichia/Shigella, and fewer beneficial ones, such as
Lachnospiraceae and Ruminococcaceae ... He cited probiotic supplements or fecal
transplants as two possible therapy approaches"
-
The
diet-microbiome connection in inflammatory bowel disease - Science Daily,
9/9/19 - "The bacteria in the gut are known to be a
really important factor in tipping the scales toward disease ... And the
environmental factor that seems to contribute the most to rapid changes in the
microbiome is what you eat. Given that dogs' microbiomes are extremely similar
to those of humans, we thought this was an intriguing model to ask, 'Could diet
be impacting this disease through an impact on the microbiome?'" ... One of
these "good" microbes that can give rise to secondary bile acids was the
bacterium Clostridium hiranonis, which the researchers found in greater numbers
in dogs that went into remission ... Youngsters who responded to the therapy had
an increase in numbers of the bacteria species Clostridium scindens, which, like
C. hiranonis, is a potent producer of secondary bile acids"
-
Seeking an Obesity Cure, Researchers Turn to the Gut Microbiome - NYT,
9/10/19 - "A clinical trial published in the
journal Nature Medicine in July, for example, found that giving obese people
supplements containing a gut microbe linked to leanness in mice and humans
lowered their cholesterol, inflammation and insulin and even led to a few pounds
of weight loss compared to a control group ... Still, Dr. Yu said a capsule
containing a cocktail of beneficial microbes is never going to be a silver
bullet."
-
Gut
bacteria may be linked to high blood pressure and depression - Science
Daily, 9/5/19 - "the investigators discovered unique
patterns of bacteria from people with 1) high blood pressure plus depression; 2)
high blood pressure without depression; 3) depression with healthy blood
pressure; or 4) healthy subjects without depression or high blood pressure ...
Stevens said the results suggest different medical mechanisms of high blood
pressure that correlate with signature molecules produced by gut bacteria. These
molecules are thought to impact the cardiovascular system, metabolism, hormones
and the nervous system."
-
Diet's
effect on gut bacteria could play role in reducing Alzheimer's risk -
Science Daily, 9/3/19 - "a modified Mediterranean-ketogenic
diet produced changes in the gut microbiome and its metabolites that correlated
with reduced levels of Alzheimer's markers in the members of both study groups"
-
In Vivo Effectiveness and
Safety of Probiotics on Prophylaxis and Treatment of Oral Candidiasis -
Medscape, 8/29/19 - "Probiotics were superior to the
placebo and blank control in preventing and treating oral candidiasis in the
elderly and denture wearers" - See
probiotic products at Amazon.com.
-
Emerging Role of the Gut
Microbiome in the Progression of Nonalcoholic Fatty Liver Disease and Potential
Therapeutic Implications - Medscape, 8/26/19 -
"Multiple pathophysiologic pathways connect the gut microbiome with the
pathophysiology of NAFLD. Therefore, therapeutics that effectively target the
gut microbiome may be beneficial for the treatment of patients with NAFLD"
-
These
gut bacteria prevent mice from becoming obese -- what could that mean for us?
- Science Daily, 7/25/19 - "healthy mice have plenty of Clostridia -- a class of
20 to 30 bacteria -- but those with an impaired immune system lose these
microbes from their gut as they age. Even when fed a healthy diet, the mice
inevitably become obese. Giving this class of microbes back to these animals
allowed them to stay slim ... Mice experimentally treated so that Clostridia
were the only bacteria living in their gut were leaner with less fat than mice
that had no microbiome at all. They also had lower levels of a gene, CD36, that
regulates the body's uptake of fatty acids ... These insights could lead to a
therapeutic approach, Round says, with advantages over the fecal transplants and
probiotics that are now being widely investigated as ways to restore a healthy microbiota ... Round points out that research by others have shown that people
who are obese similarly lack Clostridia, mirroring the situation in these mice"
- See
probiotic products at Amazon.com.
-
These
gut bacteria prevent mice from becoming obese -- what could that mean for us?
- Science Daily, 7/25/19 - "healthy mice have plenty of Clostridia -- a class of
20 to 30 bacteria -- but those with an impaired immune system lose these
microbes from their gut as they age. Even when fed a healthy diet, the mice
inevitably become obese. Giving this class of microbes back to these animals
allowed them to stay slim ... Mice experimentally treated so that Clostridia
were the only bacteria living in their gut were leaner with less fat than mice
that had no microbiome at all. They also had lower levels of a gene, CD36, that
regulates the body's uptake of fatty acids ... These insights could lead to a
therapeutic approach, Round says, with advantages over the fecal transplants and
probiotics that are now being widely investigated as ways to restore a healthy microbiota ... Round points out that research by others have shown that people
who are obese similarly lack Clostridia, mirroring the situation in these mice"
-
Gut
microbes may affect the course of ALS - Science Daily, 7/22/19 -
"To reveal the mechanism by which Akkermansia may be
producing its effect, the scientists examined thousands of small molecules
secreted by the gut microbes. They zeroed in on one molecule called nicotinamide
(NAM): Its levels in the blood and in the cerebrospinal fluid of ALS-prone mice
were reduced following antibiotic treatment and increased after these mice were
supplemented with Akkermansia, which was able to secrete this molecule. To
confirm that NAM was indeed a microbiome-secreted molecule that could hinder the
course of ALS, the scientists continuously infused the ALS-prone mice with NAM.
The clinical condition of these mice improved significantly. A detailed study of
gene expression in their brains suggested that NAM improved the functioning of
their motor neurons" - Note: See previous newsletters.
Akkermansia is the one that may help with weight control.
-
Gut
microbes protect against neurologic damage from viral infections - Science
Daily, 7/16/19 - "Gut microbes produce compounds that prime immune cells to
destroy harmful viruses in the brain and nervous system ... Mice treated with
antibiotics before the onset of disease were unable to defend themselves. They
also had fewer immune cells called microglia, which help flag viruses for
destruction by other immune cells" - See
probiotic products at Amazon.com.
-
'First Evidence' Links Gut
Bacteria, Fibromyalgia - Medscape, 7/9/19 - "women
with fibromyalgia had significant differences in 19 species of gut bacteria
compared with healthy controls. They also had higher serum levels of butyrate
and lower levels of propionate ... Evidence is mounting on the critical role of
the gut microbiota in a variety of pathologies, including, but not limited to,
metabolic, cardiovascular, oncologic, neurologic, and psychiatric disorders"
-
A Probiotic for Obesity - NYT, 7/1/19 - "Compared
with the placebo group, those who took pasteurized A. muciniphila had
significantly improved insulin sensitivity and total cholesterol, and decreases
in several blood markers of inflammation and liver dysfunction. They also had
decreased body weight, fat mass and waist circumference, though those
differences were not statistically significant"
-
Gut Bacteria Help May Boost Obese People's Health - WebMD. 7/1/19 -
""But
that was just a simple correlation," Cani said. So several years ago, his team
started to look deeper. First, they found that in lab mice, Akkermansia -- given
as live bacteria -- helped prevent weight gain from a high-fat diet ... The
important conclusion is, this type of supplement is safe and feasible ... After
three months, people on the pasteurized supplement had lost 5 pounds, on
average. Their insulin sensitivity improved by 30% in relation to the placebo
group, whose sensitivity worsened. And their total cholesterol dipped by about
9% versus the placebo group, the findings showed" - Note: I Goggled it.
I don't think it's available yet. Here's what Amazon comes up with for
probiotics for weight loss.
-
Could a Gut Bacteria Supplement Make Us Run Faster? - NYT, 6/26/19 -
"Given these findings, the researchers “are optimistic”
that athletes and inactive people might likewise benefit from popping a little
supplemental Veillonella, says Aleksandar Kostic, an assistant professor of
microbiology at Harvard Medical School and the Joslin Diabetes Center and the
study’s senior author. He, like several of his co-authors, has equity in a new
company that plans to offer such supplements. (The current study was funded by
the Wyss Institute for Biologically Inspired Engineering at Harvard and the
National Institutes of Health, with no contributions from the new company.) ...
“What excites me is the idea that this might help people who find exercise
difficult to increase their exercise capacity,” Dr. Kostic says, while also
potentially improving the performance of already-fit athletes"
-
Bacteria from your gut may be the key to running farther - engadget, 6/25/19
- "The researchers found the bacteria after examining
the poop of 10 Boston Marathon runners. To generate energy for itself,
Veillonella breaks down lactic acid, which is produced at a higher level when
athletes perform particularly strenuous activities. To determine if the bacteria
was making a difference, the researchers isolated a strain of it and inserted it
into 16 mice, then placed them on a treadmill. The mice with the bacteria in
their stomachs were able to run for 13 percent longer than mice who didn't get
the benefit of Veillonella -- a small difference, but one that could make a huge
difference in an athletic competition in which every little advantage counts"
- See
probiotic products at Amazon.com.
-
Gut
bacteria associated with chronic pain for first time - Science Daily,
6/20/19 - "We also saw that the severity of a patient's
symptoms was directly correlated with an increased presence or a more pronounced
absence of certain bacteria -- something which has never been reported before
... At this point, it's not clear whether the changes in gut bacteria seen in
patients with fibromyalgia are simply markers of the disease or whether they
play a role in causing it"
-
Unhealthy gut promotes spread of breast cancer - Science Daily, 6/10/19 -
"disrupting the microbiome of mice caused hormone
receptor-positive breast cancer to become more aggressive. Altering the
microbiome, the collection of microorganisms that live in the gut and elsewhere,
had dramatic effects in the body, priming the cancer to spread ... When we
disrupted the microbiome's equilibrium in mice by chronically treating them
antibiotics, it resulted in inflammation systemically and within the mammary
tissue ... In this inflamed environment, tumor cells were much more able to
disseminate from the tissue into the blood and to the lungs, which is a major
site for hormone receptor-positive breast cancer to metastasize ... Most breast
cancers -- 65 percent or more -- are hormone receptor positive. That means their
growth is fueled by a hormone, either estrogen or progesterone ... A healthy
diet, high in fiber, along with exercise, sleep -- all of those things that
contribute to positive overall health" - See
probiotic products at Amazon.com
and
prebiotic supplements at Amazon.com.
-
Could
boosting the gut microbiome be the secret to healthier older age? - Science
Daily, 6/4/19 - "Co-housing young and aged mice (mice
naturally like to sample the faecal pellets of other mice!) or more directly
performing faecal transfer from young to aged mice boosted the gut immune system
in the aged mice, partly correcting the age-related decline ... To our surprise,
co-housing rescued the reduced gut immune response in aged mice. Looking at the
numbers of the immune cells involved, the aged mice possessed gut immune
responses that were almost indistinguishable from those of the younger mice ...
The results show that the poor gut immune response is not irreversible and that
the response can be strengthened by challenging with appropriate stimuli,
essentially turning back the clock on the gut immune system to more closely
resemble the situation in a young mouse ... By demonstrating the effectiveness
of interventions that have a positive impact on the composition of the gut
microbiome, this research suggests that faecal transplants, probiotics,
co-habitation and diet might all prove to be ways to facilitate healthy ageing"
- Note the word "probiotics".
-
A gut
check for heart failure patients - Science Daily, 5/26/19 -
"Heart failure patients had lower biodiversity of
intestinal microbes than healthy controls, with differences in the two main
phyla of bacteria present in the human gut. Patients with heart failure had a
lower ratio of Firmicutes/Bacteroidetes (F/B) compared to controls, and this
difference was even more pronounced when the cause of heart failure was non-ischaemic
... Dietary and outcome analyses were performed in heart failure patients.
Patients who had a heart transplant or died had lower biodiversity and a lower
F/B ratio than controls. Regarding diet, bacterial diversity and Firmicutes
levels were positively associated with fibre intake ... Our findings suggest
that the altered microbiota composition found in patients with chronic heart
failure might be connected to low fibre intake"
-
Anxiety
might be alleviated by regulating gut bacteria - Science Daily,
5/20/19 - "People who experience anxiety symptoms might
be helped by taking steps to regulate the microorganisms in their gut using
probiotic and non-probiotic food and supplements ... Of the 14 studies that had
used probiotics as the intervention, more than a third (36%) found them to be
effective in reducing anxiety symptoms, while six of the remaining seven studies
that had used non-probiotics as interventions found those to be effective -- a
86% rate of effectiveness ... Some studies had used both the IRIF (interventions
to regulate intestinal microbiota) approach and treatment as usual ... The
authors say one reason that non-probiotic interventions were significantly more
effective than probiotic interventions was possible due to the fact that
changing diet (a diverse energy source) could have more of an impact on gut
bacteria growth than introducing specific types of bacteria in a probiotic
supplement ... There are two kinds of interventions (probiotic and non-probiotic
interventions) to regulate intestinal microbiota, and it should be highlighted
that the non-probiotic interventions were more effective than the probiotic
interventions" - See
probiotic products at Amazon.com
and
prebiotic supplements at Amazon.com.
-
Probiotics May Reduce
Rehospitalization in Bipolar Disorder - Medscape, 4/15/19 -
"Patients receiving the probiotic had a significantly
decreased risk of being hospitalized. About 24% of patients were rehospitalized
in the treatment group, compared with approximately 73% in the placebo group.
Also, individuals receiving the probiotic were rehospitalized for much shorter
periods of time (2.8 vs 8.3 days) ... Another part of this study that was quite
interesting, which I haven't really seen in a lot of trials to date, was that
the researchers looked at a number of biomarkers to establish what's called a
neuroinflammatory index. They looked at a group of antigens to things like
gliadin, toxoplasmosis, or the Mason‐Pfizer monkey virus. They stratified their
sample and found that individuals with high neuroinflammatory markers who
received the probiotic had a 90% reduced risk of being rehospitalized for
mania."
-
Here's Everything You Need to
Know About Gut Health - Time, 3/25/19 - "Everyone’s
microbiome is unique, but there are a few generalities about what’s healthy and
what’s not. “In healthy people, there is a diverse array of organisms,” says Dr.
Gail Hecht, chair of the American Gastroenterological Association Center for Gut
Microbiome Research & Education. (Most of those organisms are bacteria, but
there are viruses, fungi and other microbes as well.) “In an unhealthy
individual, there’s much less diversity, and there seems to be an increase of
bacteria we associate with disease.”"
-
Fountain of youth for heart health may lie in the gut - Science Daily,
3/19/19 - "When you suppressed the microbiome of the old
mice, their vascular health was restored to that of young mice," said senior
author and professor Doug Seals, director of the Integrative Physiology of Aging
Laboratory. "This suggests there is something about those microorganisms that is
causing vascular dysfunction ... In general, in the old mice, we saw an
increased prevalence of microbes that are pro-inflammatory and have been
previously associated with diseases ... For instance, the old mice hosted
significantly more Proteobacteria, a phyla that includes Salmonella and other
pathogens, and pro-inflammatory Desulfovibrio ... Old mice had three times as
much TMAO (trimethylamine N-oxide), a metabolite shown in previous studies to be
linked to increased risk of atherosclerosis ... We now suspect that, with age,
the gut microbiota begins producing toxic molecules, including TMAO, which get
into the blood stream, cause inflammation and oxidative stress and damage tissue
... they are absolutely not suggesting people use antibiotics as a
cardiovascular fountain of youth ... But they do believe that diets high in
probiotic-rich cultured food (yogurt, kefir, kimchi) and prebiotic fiber could
play a role in preventing heart disease by promoting a healthy gut microbiome
... They're also studying a compound called dimethyl butanol, found in some
olive oils, vinegars and red wines, which blocks the bacterial enzyme required
to produce TMAO ... The fountain of youth may actually lie in the gut" -
See
Probiotic products at Amazon.com.
-
High-Fiber Diet May Help Your Gut Battle Melanoma - WebMD. 2/27/19 -
"New research suggests that a diet that's full of fiber
appears to lead to more diverse intestinal bacteria (microbiome). In turn, a
thriving gut microbiome is linked to a stronger response to an immune therapy
for the aggressive skin cancer ... We found that patients eating a high-fiber
diet at the start of therapy were about five times more likely to respond to the
anti-PD-1 immunotherapy"
-
Efficacy and Safety of
Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild
Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind,
Placebo-Controlled Clinical Trial - Nutrients 2019, 11(2), 305 -
"Compared to the placebo group, the DW2009 group showed
greater improvements in the combined cognitive functions (z = 2.36, p for
interaction = 0.02), especially in the attention domain (z = 2.34, p for
interaction = 0.02). Cognitive improvement was associated with increased serum
BDNF levels after consumption of DW2009 (t = 2.83, p = 0.007). The results of
this clinical trial suggest that DW2009 can be safely administered to enhance
cognitive function in individuals with MCI. Increased serum BDNF levels after
administering DW2009 may provide preliminary insight into the underlying effects
of cognitive improvement, which suggests the importance of the gut-brain axis in
ameliorating cognitive deficits in MCI" - [Nutra
USA]
-
Gut Bacteria Tied to
Depression - Medscape, 2/11/19 - "In analyzing data
from 1054 individuals enrolled in the Flemish Gut Flora Project (FGFP),
investigators found two groups of bacteria — Coprococcus and Dialister — were
consistently depleted in people diagnosed with depression, regardless of
antidepressant treatment ... They validated the results in an independent cohort
of 1063 individuals from the Dutch LifeLines DEEP cohort and in a group of
patients with treatment-resistant major depressive disorder ... They also found
that Faecalibacterium and Coprococcus bacteria were consistently associated with
higher quality of life indicators. Both bacteria produce butyrate, a short-chain
fatty acid that strengthens the epithelial defense barrier and reduces
intestinal inflammation, and both have been reported to be depleted in
association with inflammatory bowel disease and depression"
-
The
involvement of the gut in Parkinson's disease: hype or hope? - Science
Daily, 2/7/19 - "The gut has emerged as one of the new
frontiers in PD research," commented Patrik Brundin, MD, PhD, Van Andel Research
Institute, Grand Rapids, MI, USA, and J. William Langston, MD, Stanford Udall
Center, Department of Pathology, Stanford University, Palo Alto, CA, USA,
Editors-in-Chief of the Journal of Parkinson's Disease. "We predict there will
be several advances regarding the gut in the coming 20 years. Changes in the gut
might be utilized to diagnose PD earlier; new therapies targeting these changes
might slow disease progression, reduce constipation, and improve gut function in
patients who have already been diagnosed."
-
Could Germs in Your Gut Send You Into Depression? - WebMD, 2/4/19 -
"Researchers found that among over 2,100 adults, those
with depression showed differences in specific groups of gut bacteria. And
people with higher concentrations of certain other gut bugs generally reported
better mental well-being ... Those microbes are believed to do much more than
aid in digestion. Research suggests they are involved in everything from immune
system defenses to producing vitamins, anti-inflammatory compounds and even
chemicals that influence the brain ... levels of two specific groups of gut
bacteria -- Coprococcus and Dialister -- were "consistently depleted" in people
with depression ... Meanwhile, people with higher levels of Coprococcus, and
another group of bacteria called Faecalibacterium, typically gave better ratings
to their quality of life ... Both types of bacteria break down dietary fiber to
produce an anti-inflammatory compound called butyrate"
-
'Bugs'
in the gut might predict dementia in the brain - Science Daily, 1/10/19 -
"Researchers studying the population of bacteria
and microbes in the intestines, known as gut microbiota, have found these "bugs"
impact risks for diseases of the heart and more. Japanese researchers studied
128 (dementia and non-dementia) patients' fecal samples and found differences in
the components of gut microbiota in patients with the memory disorder suggesting
that what's in the gut influences dementia risk much like other risk factors."
-
Probiotics could help millions of patients suffering from bipolar disorder -
Science Daily, 12/13/18 - "a probiotic supplement may
reduce inflammation of the gut, which is known to exacerbate bipolar disorder
... In recent years, research has demonstrated a strong link between the
gastrointestinal tract and the central nervous system. This connection, named
the "gut-brain axis" (GBA), allows for crosstalk between the endocrine, immune,
and autonomic nervous systems ... There is also mounting evidence linking
imbalances in the microbial species that make up the gut microbiome to a number
of health problems including allergies, autoimmune disorders, and psychiatric
mood disorders ... Overall, these results indicate that changes in intestinal
inflammation can alter the trajectory of psychiatric mood disorders and that
modulating the intestinal microbiota may be a new avenue of treatment for
patients suffering from these diseases"
-
The Efficacy of
Prebiotics, Probiotics, Synbiotics and Antibiotics in Irritable Bowel Syndrome
- Medscape, 11/22/18 - "The search identified 4017
citations. Data for prebiotics and synbiotics were sparse. Fifty-three RCTs of
probiotics, involving 5545 patients, were eligible. Particular combinations of
probiotics, or specific species and strains, appeared to have beneficial effects
on global IBS symptoms and abdominal pain, but it was not possible to draw
definitive conclusions about their efficacy. There were five trials of similar
design that used rifaximin in non-constipated IBS patients, which was more
effective than placebo (RR of symptoms persisting = 0.84; 95% CI 0.79–0.90).
Adverse events were no more common with probiotics or antibiotics"
-
Probiotics, Fecal
Transplant Promising in Ulcerative Colitis - Medscape, 10/15/18 -
"the researchers reviewed 16 relevant randomized
controlled trials that used markedly different protocols ... Overall, probiotics
were effective for clinical remission and clinical response in ulcerative
colitis. And when we divided it to see which probiotic actually was effective,
FMT was number one and VSL#3 was number two"
-
Artificial sweeteners have toxic effects on gut microbes - Science Daily,
10/1/18 - "The collaborative study indicated relative toxicity of six artificial
sweeteners (aspartame, sucralose, saccharine, neotame, advantame, and acesulfame
potassium-k) and 10 sport supplements containing these artificial sweeteners.
The bacteria found in the digestive system became toxic when exposed to
concentrations of only one mg./ml. of the artificial sweeteners"
-
Colon
cancer is caused by bacteria and cell stress - Science Daily, 9/18/18 -
"it is not cell stress alone that leads to tumour
growth, but the combination of stress and microbiota that favours cancer growth
... In certain patients, the protein ATF6 could serve as a diagnostic marker for
an increased risk of colon cancer and could indicate the start of therapy at an
early stage ... a microbial therapy is conceivable, when we know more about the
composition of the bacterial flora. What now became clear, however: Chronic
inflammation has no effect on cancer development in the colon"
-
Probiotic use may reduce antibiotic prescriptions - Science Daily, 9/14/18 -
"when the results from twelve studies were pooled
together, infants and children were 29% percent less likely to have been
prescribed antibiotics if they received probiotics as a daily health supplement.
When the analysis was repeated with only the highest quality studies, this
percentage increased to 53%"
-
Gut
bacteria markers could be a 'smoking gun' for liver disease - Science Daily,
6/25/18 - "NAFLD starts with the build-up of fat in
liver and can lead to scarring and cirrhosis, where the scarred organ eventually
shrinks and the risks of liver failure and cancer increase. Fatty liver also
increases the risk of developing type 2 diabetes and cardiovascular diseases ...
Their analysis also uncovered a link between the presence of fatty liver disease
and subtle changes in the makeup of the microbiome itself. The more advanced the
disease, the more the total number of genes encoded by gut bacteria began to
decrease, an indirect measure that the microbiome was less diverse -- made up of
fewer different types of bacteria ... Researchers have already discovered more
than 10 million active genes linked to the microbes in our gut -- 500 times the
number of genes in the human genome -- but their function remains largely
unknown. However, previous studies have shown the number of active microbial
genes drops dramatically with metabolic disorders, such as obesity ... According
to the team, the drop in microbial diversity reveals that key gut bugs may be
lost in patients with fatty liver disease"
-
Probiotics can protect the skeletons of older women - Science Daily, 6/21/18
- "A random method determined which women received the
active treatment with the Lactobacillus reuteri 6475 bacteria and which received
powder without bacteria. Neither the researchers nor the women knew who received
the active powder during the study ... The women who received the powder with
active bacteria had lost only half as much bone in the skeleton compared with
those who received inactive powders"
-
How the
gut influences neurologic disease - Science Daily, 5/16/18 -
"They found that compounds resulting from the breakdown
of tryptophan can cross the blood-brain barrier, activating an anti-inflammatory
pathway that limits neurodegeneration. The researchers also studied human
multiple sclerosis brain samples, finding evidence of the same pathway and
players ... Activation of this same pathway has recently been linked to
Alzheimer's disease and glioblastoma. The Ann Romney Center for Neurologic
Diseases, of which Quintana is a part, brings experts together to accelerate
treatment for these diseases, as well as multiple sclerosis Parkinson's disease
and ALS (Lou Gehrig's disease) ... Quintana and his colleagues plan to further
study the connections to neurologic diseases, and are also optimizing small
molecules as well as probiotics to identify additional elements that participate
in the pathway and new therapies."
-
Probiotics Effective for
Primary Prevention of C. Diff - Medscape, 5/7/18 -
"Probiotic prophylaxis reduced the odds of CDI by 63% in unadjusted analyses"
-
Gut
microbiome plays an important role in atherosclerosis - Science Daily,
5/2/18 - "patients with unexplained atherosclerosis had
significantly higher blood levels of these toxic metabolites that are produced
by the intestinal bacteria ... "The finding, and studies we have performed
since, present us with an opportunity to use probiotics to counter these
compounds in the gut and reduce the risk of cardiovascular disease," said Gregor
Reid, PhD, professor at Schulich Medicine & Dentistry, scientist at Lawson"
- See
probiotic products at Amazon.com.
-
Growing
evidence that probiotics are good for your liver - Science Daily, 4/23/18 -
"Saeedi and his colleagues focused their study on the
probiotic Lactobacillus rhamnosus GG (known as LGG), a species common in many
over-the-counter probiotic formulations. They gave mice food laced with LGG for
two weeks and then examined how they responded to a high dose of acetaminophen
(the active ingredient in Tylenol®) ... mice receiving the probiotic treatment
suffered less liver damage when presented with an overdose of acetaminophen
compared with mice that did not receive probiotics ... Administration of the
probiotic LGG to mice improves the antioxidant response of the liver, protecting
it from oxidative damage produced by drugs such as acetaminophen ... Other
studies in mice have previously shown that LGG can protect against alcoholic
liver disease and non-alcoholic fatty liver disease" - See
probiotic products at Amazon.com.
-
Older Age, Long-term
Antibiotic Use Linked to Mortality Risk - Medscape, 4/2/18 -
"women who used antibiotics for 2 months or longer were
27% more likely to die of all causes and were as much as 57% more likely to die
of cardiovascular causes compared with those with no antibiotic use ...
Antibiotic use has been linked with changes to the gut microbiome that can in
fact last for years, while infections from antibiotic resistances remain an
ever-increasing concern" - See
probiotic products at Amazon.com.
-
Fish
oil and probiotic supplements in pregnancy may reduce risk of childhood
allergies - Science Daily, 2/28/18 - "when pregnant
women took a daily fish oil capsule from 20 weeks pregnant, and during the first
three to four months of breastfeeding, risk of egg allergy in the child was
reduced by 30 per cent ... taking a daily probiotic supplement from 36-38 weeks
pregnant, and during the first three to six months of breastfeeding, reduced the
risk of a child developing eczema by 22 per cent" - See
fish oil supplements at Amazon.com
and
probiotic products at Amazon.com.
-
Gut Bacteria Less Diverse
in PCOS; Could Probiotics Be a Therapy? - Medscape, 1/24/18 -
"In terms of the gut microbiome, it is possible that
decreased bacterial diversity results in changes in gut function that could
exacerbate diseases including PCOS, though much work remains to be done to
understand how changes in the gut microbiome influence host physiology"
-
Prebiotics in infant formula could improve learning and memory and alter brain
chemistry - Science Daily, 1/17/18 - "Starting on
the second day of life, piglets were given a cow's milk-based infant formula
supplemented with polydextrose (PDX), a synthetic carbohydrate with prebiotic
activity, and galactooligosaccharide (GOS), a naturally occurring prebiotic.
When the piglets were 25 days old, Fleming took them through several learning,
memory, and stress tests. After 33 days, blood, brain, and intestinal tissues
were collected for analysis ... Pigs fed PDX and GOS spent more time playing
with new objects than pigs who didn't receive the prebiotic supplements. The
preference for novel objects, an indication of natural curiosity, is a sign of
healthy brain development and points towards positive development of learning
and memory" - See
probiotic products at Amazon.com.
-
Can
Muesli help against arthritis? - Science Daily, 1/12/18 -
'We were able to
show that a bacteria-friendly diet has an anti-inflammatory effect, as well as a
positive effect on bone density' explains Dr. Mario Zaiss, who is leading the
team behind the study. 'Our findings offer a promising approach for developing
innovative therapies for inflammatory joint diseases as well as for treating
osteoporosis, which is often suffered by women after the menopause. We are not
able to give any specific recommendations for a bacteria-friendly diet at the
moment, but eating muesli every morning as well as enough fruit and vegetables
throughout the day helps to maintain a rich variety of bacterial species.' - See
muesli at Amazon.com and
probiotic products at Amazon.com.
-
Gut
microbes can protect against high blood pressure - Science Daily, 11/15/17 -
"a high-salt diet shrinks the population of a certain
type of beneficial bacteria. As a result, pro-inflammatory immune cells called
Th-17 cells grow in number ... treatment with a probiotic could reverse these
effects ... When subjects were given a commercially available probiotic for a
week before going on a high-salt diet, their gut lactobacillus levels and blood
pressure remained normal" - See
probiotic products at Amazon.com.
-
Gut
bacteria are sensitive to salt: Link to autoimmune disease and hypertension
- Science Daily, 11/15/17 - "When the animals were
given probiotic lactobacilli in addition to the high-salt diet, however, the
frequency of TH17 helper cells decreased once again and blood pressure dropped.
The probiotics also alleviated the clinical symptoms of experimental autoimmune
encephalomyelitis, a disease model for MS"
-
Gut Bacteria Profile
Remains Stable With Healthy Aging - Medscape, 10/25/17 -
"The main conclusion is that if you are ridiculously
healthy and 90 years old, your gut microbiota is not that different from a
healthy 30-year-old in the same population ... This demonstrates that
maintaining diversity of your gut as you age is a biomarker of healthy aging,
just like low-cholesterol is a biomarker of a healthy circulatory system ...
Whether this is cause or effect is unknown, but it suggests that resetting an
elderly microbiota to that of a 30-year-old might help promote health, if the
microbiota is outside the norm"
-
'Ridiculously healthy' elderly have the same gut microbiome as healthy 30
year-olds - Science Daily, 10/11/17 - "The main
conclusion is that if you are ridiculously healthy and 90 years old, your gut
microbiota is Whether this is cause or effect is unknown, but the study authors
point out that it is the diversity of the gut microbiota that remained the same
through their study groupnot that different from a healthy 30 year old in the
same population ... maintaining diversity of your gut as you age is a biomarker
of healthy aging, just like low-cholesterol is a biomarker of a healthy
circulatory system ... The researchers suggest that resetting an elderly
microbiota to that of a 30-year-old might help promote health" - See
probiotic products at Amazon.com.
-
Good-guy bacteria may help cancer immunotherapies do their job - Science
Daily, 10/5/17 - "there were certain good-guy bacteria
that are needed to optimize the effectiveness of checkpoint inhibitors. These
bacteria somehow prime your immune system so that it's better able to attack
cancer cells and kill them ... As a group, patients who responded well to the
immunotherapy had three specific bacteria: Bacteroides thetaiotaomicron ...
Faecalibacterium prausnitzii ... Holdemania filiformis ... All three are common
normal flora in the human intestinal tract ... Is it something the bacteria are
making? We examined metabolites in these subjects and found the strongest
correlation between anacardic acid, present in cashews and mangoes, and the
beneficial bacteria ... they may lead eventually to a probiotic cocktail that
could be given along with immunotherapy to enhance the chance of response"
-
New
research on probiotics in the prevention and treatment of colon cancer -
Science Daily, 9/13/17 - "These results suggest that
alteration of the gut microbiome with probiotics may become a new preventative
or therapeutic strategy for patients at risk for inflammatory bowel disease
(IBD)-associated CRC ... The active probiotic also reduced inflammation induced
by the carcinogen plus DSS, as indicated by suppressed pro-inflammatory cytokine
gene expression (i.e., those encoding KC, interleukin (IL)-22, IL-6, tumor
necrosis factor (TNF), and IL-1?) and reduced cytokine concentrations in plasma
(i.e., KC, IL-22, and IL-6). The active probiotic also counteracted an increase
in immature myeloid cells induced by the carcinogen"
-
Intestinal Microbiota Is
Altered in Patients With Colon Cancer and Modified by Probiotic Intervention
- Medscape, 8/30/17 - "Our results show promise for
potential therapeutic benefits in CRC by manipulation of the microbiota"
-
Peanut Allergy: Is Oral
Immunotherapy With Probiotic a Cure? - Medscape, 8/24/17 -
"Four years after treatment stopped, 70% of patients who
were desensitized via 18 months of treatment with combined probiotic and peanut
oral immunotherapy (PPOIT) in a randomized controlled trial remain unresponsive
to peanut protein despite no intervening therapy" - See
probiotic products at Amazon.com.
-
Gut
bacteria might one day help slow down aging process - Science Daily, 6/15/17
- "Scientists at Baylor College of Medicine and the
University of Texas Health Science Center at Houston have identified bacterial
genes and compounds that extend the life of and also slow down the progression
of tumors and the accumulation of amyloid-beta, a compound associated with
Alzheimer's disease, in the laboratory worm C. elegans ... Our finding suggests
that products from bacteria today can still chime in the communication between
mitochondria in our cells. We think that this type of communication is very
important and here we have provided the first evidence of this"
-
Pre-clinical study suggests Parkinson's could start in gut endocrine cells -
Science Daily, 6/15/17 - "Recent research on Parkinson's
disease has focused on the gut-brain connection, examining patients' gut
bacteria, and even how severing the vagus nerve connecting the stomach and brain
might protect some people from the debilitating disease ... Rather than using
hormones to communicate indirectly with the nervous system, these gut endocrine
cells physically connect to nerves, providing a pathway to communicate with the
brain ... This suggests they are able to communicate directly with the nervous
system and brain" - Note: It's another reason not to kill your gut
bacteria with antibiotics and possible advantages of probiotics if you've taken
antibiotics.
-
Probiotic use linked to improved symptoms of depression - Science Daily,
5/23/17 - "twice as many adults with irritable bowel
syndrome (IBS) reported improvements from co-existing depression when they took
a specific probiotic than adults with IBS who took a placebo ... The study
provides further evidence of the microbiota environment in the intestines being
in direct communication with the brain" - [Abstract]
[Nutra
USA]
-
Link
between common brain disease and gut microbiome - Science Daily, 5/10/17 -
"Bacteria in the gut microbiome drive the formation of
cerebral cavernous malformations (CCMs), clusters of dilated, thin-walled blood
vessels in the brain that can cause stroke and seizures ... altering the
microbiome in CCM patients may be an effective therapy for this cerebrovascular
disease"
-
Probiotic, Red Yeast Rice
Extract Combo May Cut Cholesterol - Medscape, 5/5/17 -
"Supplementation with the probiotic Bifidobacterium
longum BB536 added to red yeast rice extract improves lipid profiles in patients
with moderate hypercholesterolemia ... A 26% reduction in LDL was what was we
had in WOSCOPS on pravastatin 40 mg. So it's a very reasonable reduction ...
Overall, compliance was excellent at 97% and no adverse effects were reported"
- See
red yeast rice at Amazon.com
and
probiotic products at Amazon.com.
-
A
probiotic stress fix - Science Daily, 3/27/17 -
"U.S. sailors and Marines face continuous periods of excessive stress in
"fight-or-flight" situations, triggering surges of chemical messengers called
neurotransmitters, often known as an adrenaline rush. While these surges are
important for relaying messages in the brain, prolonged high levels can cause
long-term health problems, including anxiety and susceptibility to infection ...
Tae Seok Moon, an engineer in the School of Engineering & Applied Science at
Washington University in St. Louis, is working to create a probiotic from a
commercially-available, beneficial bacterial strain of Escherichia coli after
receiving a three-year, $508,635 grant from the Office of Naval Research's 2017
Young Investigator Program ... We tend to think the gut and the brain are
separate, but recently, more researchers think they are connected through the
microbiota-gut-brain axis"
-
Vitamin
D improves gut flora and metabolic syndrome - Science Daily, 12/21/16 -
"a high fat diet affects the balance between good and
bad bacteria in the gut. This induces modest fatty liver and slightly raises
blood sugar levels in mice. Remarkably, an insufficient supply of vitamin D
aggravates the imbalance in gut flora, contributing to full-scale fatty liver
and metabolic syndrome ... Vitamin D deficiency decreases the production of
defensins, which are anti-microbial molecules essential to maintain healthy gut
flora" - See
vitamin D at Amazon.com.
-
Common
probiotics can reduce stress levels, lessen anxiety - Science Daily,
11/21/16 - "a common probiotic sold in supplements and
yogurt can decrease stress-related behavior and anxiety ... bacteria in the gut
altered the gene expression associated with stress- and anxiety-related pathways
in the fish allowing for increased signaling of particular neurotransmitters"
- See
probiotic products at Amazon.com.
-
Gut
bacteria affect our metabolism - Science Daily, 11/21/16 -
"Mice that receive gut bacteria transplants from
overweight humans are known to gain more weight than mice transplanted with gut
bacteria from normal weight subjects, even when the mice are fed the same diet"
-
Probiotics improve cognition in Alzheimer's patients - Science Daily,
11/14/16 - "a daily dose of probiotic Lactobacillus and
Bifidobacterium bacteria taken over a period of just 12 weeks is enough to yield
a moderate but significant improvement in the score of elderly Alzheimer's
patients on the Mini-Mental State Examination (MMSE) scale, a standard measure
of cognitive impairment ... scientists have long hypothesized that probiotics
might also boost cognition, as there is continuous two-way communication between
the intestinal microflora, the gastrointestinal tract, and the brain through the
nervous system, the immune system, and hormones (along the so-called
"microbiota-gut-brain axis"). In mice, probiotics have indeed been shown to
improve learning and memory, and reduce anxiety and depression- and OCD-like
symptoms ... Over the course of the study, the average score on the MMSE
questionnaire significantly increased (from 8.7 to 10.6, out of a maximum of 30)
in the group receiving probiotics, but not in the control group (from 8.5 to
8.0)"
-
Hard to do systems biology when you ignore 99% of us (the microbiome): Expert
- Nutra USA, 11/8/16 - "I can tell you with 90% certainty if you're lean or
obese based on your microbiome" - See
probiotic products at Amazon.com.
-
Sleep
loss tied to changes of the gut microbiota in humans - Science Daily,
10/25/16 - "Changes in the composition and diversity of
the gut microbiota have been associated with diseases such as obesity and type-2
diabetes in humans. These diseases have also been linked with chronic sleep loss
... we did however observe microbiota changes that parallel some of the
microbiota changes observed when for instance obese subjects have been compared
with normal-weight subjects in other studies, such as an increased ratio of
Firmicutes to Bacteroidetes. Longer and larger clinical sleep interventions will
be needed to investigate to what extent alterations of the gut microbiota may
mediate negative health consequences attributed to sleep loss, such as weight
gain and insulin resistance" - See
probiotic products at Amazon.com.
-
Body fat link to bacteria in
faeces - BBC, 9/26/16 - "The researchers found the
strongest links with visceral fat, where participants with a high diversity of
bacteria in their faeces had lower levels of visceral fat ... This type of body
fat is bad news because it is stored in the stomach area around important organs
such as the liver, pancreas and intestines and is linked with higher risks of
cardiovascular disease and diabetes ... One theory is that a lack of variety in
faecal bacteria could lead to the domination of high levels of gut microbes
which are good at turning carbohydrates into fat" - [Science
Daily]
-
ICU
patients lose helpful gut bacteria within days of hospital admission -
Science Daily, 8/31/16 - "treatments used in the ICU --
including courses of powerful antibiotics, medicines to sustain blood pressure,
and lack of nutrition -- can reduce the population of known healthy bacteria ...
the next step is to use the data to identify therapies -- perhaps including
probiotics -- to restore a healthy bacterial balance to patients" -
Note: No kidding. Seems like they would have figured that out by now. Every
time I've gone to the hospital such as surgery for neck cancer twelve years ago,
I was admitted thinking I could run a marathon that day and I left looking like
the walking dead. One reason is that even for minor surgery they give you
enough antibiotics via IV to kill and elephant. Another reason is lack of
sleep. I posted a study on the sleep issue about a year ago.
-
Antibiotics weaken Alzheimer's disease progression through changes in the gut
microbiome - Science Daily, 7/24/16 - "Two of the
key features of Alzheimer's disease are the development of amyloidosis,
accumulation of amyloid-ß (Aß) peptides in the brain, and inflammation of the
microglia, brain cells that perform immune system functions in the central
nervous system. Buildup of Aß into plaques plays a central role in the onset of
Alzheimer's, while the severity of neuro-inflammation is believed to influence
the rate of cognitive decline from the disease ... For this study, Sisodia and
his team administered high doses of broad-spectrum antibiotics to mice over five
to six months. At the end of this period, genetic analysis of gut bacteria from
the antibiotic-treated mice showed that while the total mass of microbes present
was roughly the same as in controls, the diversity of the community changed
dramatically. The antibiotic-treated mice also showed more than a two-fold
decrease in Aß plaques compared to controls, and a significant elevation in the
inflammatory state of microglia in the brain. Levels of important signaling
chemicals circulating in the blood were also elevated in the treated mice"
- Note: It would seem like changing the gut balance via probiotics would
be the way to go, not taking antibiotics. See
probiotic products at Amazon.com.
-
Gut
bacteria can cause, predict and prevent rheumatoid arthritis - Science
Daily, 7/11/16 - "Dr. Taneja treated one group of
arthritis-susceptible mice with a bacterium, Prevotella histicola, and compared
that to a group that had no treatment. The study found that mice treated with
the bacterium had decreased symptom frequency and severity, and fewer
inflammatory conditions associated with rheumatoid arthritis. The treatment
produced fewer side effects, such as weight gain and villous atrophy -- a
condition that prevents the gut from absorbing nutrients -- that may be linked
with other, more traditional treatments"
-
Consuming probiotics promotes weight loss, reduces BMI - Science Daily,
7/11/16 - "Researchers from the Department of
Cardiology, Taizhou People's Hospital, Taizhou, China combined the findings of
25 randomized human trials investigating the impact of probiotic consumption on
body weight and BMI in over 1,900 healthy adults. They found taking probiotics
reduced BMI and body weight with the greatest reduction in BMI occurring in
overweight adults. Interestingly, ingesting more than one type of probiotic and
taking probiotics for 8 weeks or more resulted in increased weight loss"
-
New study shows chronic fatigue isn’t just in your head. It may have to do with
your gut - Washington Post, 6/30/16 - "Cornell
University researchers looked at stool and blood samples of 48 people diagnosed
with chronic fatigue syndrome (or more formally, myalgic encephalomyelitis) and
at 39 healthy volunteers ... They found two main differences: Through DNA
sequencing, they found the stool samples in the patients with the condition had
less diversity in bacteria present in the gut and that there were fewer that
were anti-inflammatory. The blood samples were also distinct: There were markers
of inflammation which the researchers theorized may be due to a "leaky gut from
intestinal problems that allow bacteria to enter the blood." ... it suggests
that diet and things like probiotics may be a way to help treat the disease by
getting the gut microbiome back in balance"
-
How
altered gut microbes cause obesity - Science Daily, 6/8/16 -
"Taken together these experiments demonstrate a causal
link between alterations in the gut microbiota in response to changes in the
diet and increased acetate production ... The increased acetate in turn leads to
increased food intake, setting off a positive feedback loop that drives obesity
and insulin resistance ... Alterations in the gut microbiota are associated with
obesity and the metabolic syndrome in both humans and rodents"
-
A Comparison of the Gut
Microbiome Between Long-term Users and Non-users of Proton Pump Inhibitors -
Medscape, 6/7/16 - "Proton pump inhibitor (PPI) use is
associated with an increased risk of Clostridium difficile infection (CDI) ...
Long-term PPIs use has an effect on the gut microbiome. The alteration in the
ratio of Firmicutes to Bacteroidetes may pre-dispose to the development of CDI"
-
Connections between gut microbiota and the brain - Science Daily, 5/29/16 -
"the gut and the brain communicate with each other via several routes including
the vagus nerve, the immune system, the enteric nervous system or by way of
microbial metabolic processes. For instance, intestinal bacteria convert
carbohydrates into short chain fatty acids, e.g. in butyric acid. This
strengthens the connections between the cells and reinforces the blood-brain
barrier, which serves as a cellular wall to protect the brain from infections
and inflammations ... Elderly individuals who are in poor health often have a
lower diversity of microorganisms in their microbiome or inflammation-promoting
manifestations" - See
probiotic products at Amazon.com.
-
How to feed a happy, healthy gut - Washington Post, 5/27/16 -
"A healthy, balanced gut microbiota promotes a strong
immune system and lower levels of chronic inflammation. An unhealthy microbiota
has been linked to obesity, asthma, allergies and autoimmune disorders such as
celiac disease, Type 1 diabetes, inflammatory bowel disease and rheumatoid
arthritis. Increasingly, chronic inflammation is also thought to be a root cause
of cardiovascular disease, Type 2 diabetes and some forms of cancer ... a diet
high in refined, heavily processed foods will send our microbiota out of balance
... a plant-based diet with lots of fiber and regular consumption of fermented
foods nourishes and stimulates beneficial bacteria, which over time can shift
the balance of your microbiota in a healthier direction ... Your microbiota
adapts to its environment, and if that environment doesn’t provide the fiber it
needs, your microbes will instead dine on the thin layer of mucus that protects
your intestinal lining, potentially leading to a “leaky gut” and all number of
health problems ... Diets high in saturated fat are harmful to microbiota
diversity, so opt for plant-based sources of monounsaturated fats such as olive
oil, avocados, nuts and seeds"
-
Gut
bacteria may contribute to poor health in patients with kidney disease -
Science Daily, 5/26/16 - "There has been increasing awareness that the gut
microbiota is not only pivotal for human health but is also involved in various
disease processes, including obesity and diabetes mellitus ... This study adds
evidence that the gut microbiota may likewise be a contributor to the disease
burden in patients with a diminished kidney function. Furthermore, this
knowledge may pave the way for novel therapeutic interventions by both dietary
measures and drugs, thereby hopefully improving the prognosis and quality of
life of kidney disease patients"
-
Probiotics stop menopause-like bone loss in mice - Science Daily, 4/27/16 -
"treated female mice twice a week with Lactobacillus
rhamnosus GG (LGG) ... A month after ovary removal, mice that were not treated
with probiotic bacteria had lost half of their bone density. But the bone
density in probiotic-treated mice stayed the same ... In mice that did not have
their ovaries removed, probiotic treatment actually led to an increase in bone
density" - Note: Lactobacillus rhamnosus is one of the bacterial in the
Garden of Life Primal Defense ULTRA I take.
-
Gut
bacteria could help prevent cancer - Science Daily, 4/13/16 -
"In the UCLA study the bacterium reduced gene damage and
significantly reduced inflammation -- a critical goal because inflammation plays
a key role in many diseases, including cancer, neurodegenerative diseases, heart
disease, arthritis and lupus, and in the aging process ... the mice that were
receiving only the beneficial microbiota produced metabolites that are known to
prevent cancer. Those mice also had more efficient fat and oxidative metabolism,
which the researchers believe might also lower the risk for cancer ... Among the
other results, in the mice receiving only the good bacteria, lymphoma formed
only half as quickly as it did in the other mice. In addition, mice with the
good bacteria lived four times longer and had less DNA damage and inflammation"
-
Gut Bugs May Affect Body Fat, 'Good' Cholesterol - WebMD, 9/10/15 -
"The size of your waistline may depend to some degree on
the specific bacteria dwelling within your gut ... As recent research has
revealed, those bugs do much more than support good digestion: They aid in
everything from immune function, to metabolizing drugs to producing vitamins,
anti-inflammatory compounds and even chemicals that relay messages among brain
cells ... C-sections deprive newborns of beneficial bacteria from the birth
canal, while breast milk feeds gut bacteria ... Diets filled with processed
foods are also thought to be at fault ... the gut microbiome can be changed
through diet"
-
Probiotics improve behavioral symptoms of chronic inflammatory diseases in mice
- Science Daily, 7/28/15 - "Mice that received the
probiotics spent more time engaging in social behaviors compared to mice that
received a placebo ... Mice that received the probiotics had lower blood levels
of TNF-α and fewer activated immune cells in the brain compared to mice that
received a placebo ... The findings suggest that probiotics improved behavioral
symptoms by altering communication between the immune system and the brain"
-
Link
between intestinal bacteria, depression found - Science Daily, 7/28/15 -
"We are starting to explain the complex mechanisms of
interaction and dynamics between the gut microbiota and its host. Our data show
that relatively minor changes in microbiota profiles or its metabolic activity
induced by neonatal stress can have profound effects on host behaviour in
adulthood"
-
Dairy
products boost effectiveness of probiotics - Science Daily, 7/17/15 -
"The mice that ingested the probiotic in milk had
reduced symptoms compared to those that were fed milk without the probiotic, and
the ones that received the probiotic within a nonfood supplement"
-
Gut
check: Does a hospital stay set patients up for sepsis by disrupting the body’s
microbiome? - Science Daily, 6/1/15 - "We know that
a major cause of microbiome disruption is antibiotic use. This study hints -- it
does not prove, but it hints -- that profligate use of antibiotics might not
just be bad because of antibiotic resistance. Profligate use of antibiotics
might also, via the microbiome, put patients at increased risk of both all kinds
of other infections, and to having a particularly bad response ('sepsis') to
those infections" - Note: It just seems like even if you go in for
minor surgery they give you enough antibiotics via IV to kill an elephant.
-
Probiotics in Preventing
Recurrent UTIs in Women - Medscape, 5/4/15 -
"Lactobacillus probiotics, taken either orally or vaginally, are likely
effective in reducing recurrent urinary tract infections in women. Although more
research is needed, probiotics should be considered a useful and safe
alternative to antibiotics. By minimizing exposure to antibiotics, nursing
professionals have the potential to decrease antibiotic resistance in
communities, de crease side effects in women, and in turn, improve their quality
of life"
-
People
less focused on recurrent bad feelings when taking probiotics - Science
Daily, 4/14/15 - "Rumination is one of the most
predictive vulnerability markers of depression ... Compared to subjects who
received the placebo intervention, participants who received the multispecies
probiotics intervention showed significantly reduced ruminative thoughts ...
Even if preliminary, these results provide the first evidence that the intake of
probiotics may help reduce negative thoughts associated with sad mood. As such,
our findings shed an interesting new light on the potential of probiotics
to serve as adjuvant or preventive therapy for depression"
-
Gut
microbial mix relates to stages of blood sugar control - Science Daily,
3/5/15 - "men whose blood sugar control stayed normal
over the year had more gut bacteria that are considered beneficial for metabolic
health, whereas those who stayed prediabetic had fewer beneficial bacteria and
more harmful bacteria ... she said it is possible that changing one's gut
bacteria could prevent diabetes" - See
probiotic products at Amazon.com
and
prebiotic supplements at Amazon.com.
-
Friendly
bacteria are protective against malaria - Science Daily, 12/4/14 -
"specific bacterial components in the human gut
microbiota can trigger a natural defense mechanism that is highly protective
against malaria transmission"
-
Proton
pump inhibitors decrease diversity in gut microbiome, increase risk for
complications - Science Daily, 11/25/14 - "people
who regularly take proton pump inhibitors (PPIs) have less diversity among their
gut bacteria ... their prolonged use has been associated with iron and vitamin
B12 deficiencies, hypomagnesemia, osteoporosis-related fractures, small
intestinal bacterial overgrowth, and community-acquired pneumonia"
-
Healthy
gut microbiota can prevent metabolic syndrome, researchers say - Science
Daily, 11/24/14 - "These results suggest that developing
a means to promote a more healthy microbiota can treat or prevent metabolic
disease ... They confirm the concept that altered microbiota can promote
low-grade inflammation and metabolic syndrome and advance the underlying
mechanism ... A person with metabolic syndrome is twice as likely to develop
heart disease and five times as likely to develop diabetes"
-
Critically ill ICU patients lose almost all of their gut microbes and the ones
left aren't good - Science Daily, 9/23/14 -
"patients with stays longer than a month had only one to four types of microbes
in their gut, as measured from fecal samples -- compared to about 40 different
types found in healthy volunteers ... the team found that adding an opioid drug
to the mix -- which mimics stress signals released by sick patients -- could
also switch behavior from a peaceful coexistence called commensalism to
virulence for some microbe pairs ... doctors should try to find ways to minimize
the excessive use of antibiotics and stabilize the microbes that do remain in
ICU patients' guts"
-
Probiotics Cut Autoimmunity
33% in Infants at Risk for Diabetes - Medscape, 9/19/14 -
"the results show a definite trend that strongly
suggests a positive effect of probiotics in infants under the age of 3 months
... One theory is that the probiotics enhance the maturity of the gut barrier to
help defend the body against environmental exposure…[to] viruses and foreign
proteins ... [With probiotics], the infant is better prepared to process these,
and in this way they may not trigger an adverse autoimmune response"
-
Artificial Sweeteners May Disrupt Body's Blood Sugar Controls - NYTimes.com,
9/17/14 - "In the initial set of experiments, the
scientists added saccharin (the sweetener in the pink packets of Sweet’N Low),
sucralose (the yellow packets of Splenda) or aspartame (the blue packets of
Equal) to the drinking water of 10-week-old mice. Other mice drank plain water
or water supplemented with glucose or with ordinary table sugar. After a week,
there was little change in the mice who drank water or sugar water, but the
group getting artificial sweeteners developed marked intolerance to glucose ...
Glucose intolerance, in which the body is less able to cope with large amounts
of sugar, can lead to more serious illnesses like metabolic syndrome and Type 2
diabetes ... When the researchers treated the mice with antibiotics, killing
much of the bacteria in the digestive system, the glucose intolerance went away
... It also suggests probiotics — medicines consisting of live bacteria — could
be used to shift gut bacteria to a population that reversed the glucose
intolerance" - [How
Can Diet Sodas Make You Fat? Study May Explain It - NBC News] - See
probiotic products at Amazon.com.
-
Microbiome and Probiotics:
Link to Arthritis - Medscape, 8/18/14 - "The gut
microbiome plays an integral role in the development and maintenance of the host
immune system ... There is intriguing yet still inconclusive evidence to support
the use of probiotics as a treatment for these diseases"
-
Probiotics Benefit Blood
Pressure in Meta-Analysis - Medscape, 7/21/14 - "the
Heart Outcomes Prevention Evaluation (HOPE) study showed a 3.3 mmHg reduction in
systolic blood pressure, along with a 1.4 mmHg reduction in diastolic blood
pressure, which were associated with a 22% relative reduction in risk of
cardiovascular mortality, MI, or stroke ... Probiotic species varied among the
trials; four studies used yogurt as the source of probiotic bacteria, two used
fermented and sour milk, one used probiotic supplements in capsule form, one
used probiotic rosehip drinks, and one used probiotic cheese ... For those who
ate more than one probiotic species, the reduction in systolic blood pressure
was 5.8 mmHg. Those who consumed probiotics for more than eight weeks had a 4.9
mmHg reduction in systolic blood pressure" - [Abstract]
-
Probiotics prevent deadly complications of liver disease, study finds -
Science Daily, 6/6/14 - "Hepatic encephalopathy is a
deterioration of brain function that is a serious complication of liver disease
... probiotics modify the gut microbiota to prevent hepatic encephalopathy in
patients with cirrhosis of the liver ... These results offer a safe,
well-tolerated and perhaps cheaper alternative to current treatments" -
See
probiotic products at Amazon.com.
-
How gut
bacteria regulate weight gain: Study provides further understanding -
Science Daily, 5/14/14 - "Recent work by other groups
has shown that bile acids act as signalling molecules in the host, almost like a
hormonal network, with an ability to influence host metabolism. What we have
done is to show that a specific mechanism exists by which bacteria in the gut
can influence this process with significant consequences for the host ... the
findings may be used as a basis for the future selection of probiotics or
dietary interventions which target this mechanism to regulate weight gain or
high cholesterol"
-
Top 4 Ways to Beat Bad Breath - ABC News, 4/30/14 -
"the bacteria species that dominate the tongues of those with healthy mouths are
different than the species that inhabit the tongues of those with bad breath.
One of the prime bacteria offenders is strain of streptococcus, but recent
research has shown that consumption of probiotics reduces streptococci counts
significantly ... While eating yogurt is a good way to get probiotics in your
diet, you might consider a simple supplement to boost your probiotic counts.
Both Flora Udo’s Choice and Garden of Life offer a good basic probiotic
supplement ... chewing xylitol gum actually decreases the amount of those same
stinky streptococci bacteria" - See
probiotic products at Amazon.com
and xylitol gum at Amazon.com.
-
Feeding
gut microbiota: Nutrition, probiotics key factors for digestive health -
Science Daily, 3/10/14 - "Diet is a central issue when
it comes to preserving our gastrointestinal health, because by eating and
digesting we literally feed our gut microbiota, and thus influence its diversity
and composition ... If this balance is disturbed, it might result in a number of
disorders, including functional bowel disorders, inflammatory bowel diseases and
other immune mediated diseases, such as celiac disease and certain allergies.
Also, metabolic conditions, such as type 2 diabetes, and perhaps even behavioral
disorders, such as autism and depression, can be linked to gut microbial
imbalances ... an increased intake of foods with high amounts of animal fat, as
well as of greasy and fried foods is not recommended, while a diet rich in
vegetables, salads and fruits has proven to be beneficial to digestive health
under normal circumstances. The same applies to fermented dairy products
containing probiotics. These are defined by the World Health Organization (WHO)
and the Food and Agriculture Organization of the United Nations (FAO) as live
organisms which, when ingested in adequate amounts, confer a health effect on
the host"
-
NICU: Probiotics Reduce
NEC, Should Be Routine, Experts Say - Medscape, 2/19/14 -
"Probiotic supplementation in preterm infants is perhaps
the best studied yet least used therapy in neonatal medicine"
-
Certain
probiotics could help women lose weight, study finds - Science Daily,
1/28/14 - "researchers recruited 125 overweight men and
women ... half the participants swallowed 2 pills daily containing probiotics
from the Lactobacillus rhamnosus family, while the other half received a placebo
... After the 12-week diet period, researchers observed an average weight loss
of 4.4 kg in women in the probiotic group and 2.6 kg in the placebo group.
However, no differences in weight loss were observed among males in the two
groups ... We don't know why the probiotics didn't have any effect on men. It
may be a question of dosage, or the study period may have been too short"
- Note: 4.4 kg is 9.7 pounds.
-
Effect of Probiotics on
Irritable Bowel Syndrome - Medscape, 1/27/14 - "Patients were randomly assigned to two groups: either to receive multispecies
probiotics (a mixture of Bifidobacterium longum, B. bifidum, B. lactis,
Lactobacillus acidophilus, L. rhamnosus, and Streptococcus thermophilus ) twice
a day for 4 weeks or to receive a placebo twice a day for 4 weeks ... The
proportion of patients whose IBS symptoms were substantially relieved at week 4
was significantly higher in the probiotics group than in the placebo group:
68.0% (17/25) versus 37.5% (9/24) (P < 0.05). Secondary end-points such as
improvement in abdominal pain/discomfort and bloating occurred in the probiotics
group but not in the placebo group"
-
The microbes in your gut may be making you fat or keeping you thin - The
Washington Post, 12/6/13 - "naturally occurring bacteria
and other microbes in the body, and possibly even viruses, can influence weight
in ways that scientists are only just beginning to understand ... Studies in
mice have shown that intestinal microbes may contribute to weight gain. A novel
experiment published this fall, for example, took gut bacteria from human twins
— in which one was lean and the other obese — and transferred them into lean
mice. The animals with bacteria from fat twins grew fat; those that received
bacteria from lean twins stayed lean"
-
Some Gut Bacteria May
Affect Colorectal Cancer Risk - Medscape, 12/6/13 -
"Because of the potentially modifiable nature of the gut bacteria, our findings
may have implications for CRC prevention ... The researchers found decreased
microbiome community diversity in patients with CRC , compared with that of
healthy participants(P = .02). In an analysis by taxa, patients with CRC had
lower relative abundances of Clostridia, at 68.6% compared with 77.8% in people
without CRC. In contrast, patients with CRC carried a higher relative abundance
of Fusobacterium (31.9% vs 11.7% for control patients) ... A higher relative
abundance of Fusobacterium was associated with increased CRC risk (multivariable
odds ratio [OR], 4.11 ... Actinobacteria Atopobium (OR, 14.36; 95% CI, 2.78 -
74.30; P < .001) and the Bacteriodetes Porphyromonas (OR, 5.17; 95% CI, 1.75 -
15.25; P = .001) were also associated with CRC risk"
-
Probiotic therapy alleviates autism-like behaviors in mice - Science Daily,
12/5/13 - "the researchers treated the mice with
Bacteroides fragilis, a bacterium that has been used as an experimental
probiotic therapy in animal models of GI disorders ... The result? The leaky gut
was corrected ... In addition, observations of the treated mice showed that
their behavior had changed. In particular, they were more likely to communicate
with other mice, had reduced anxiety, and were less likely to engage in a
repetitive digging behavior ... The B. fragilis treatment alleviates GI problems
in the mouse model and also improves some of the main behavioral symptoms ...
This suggests that GI problems could contribute to particular symptoms in
neurodevelopmental disorders"
-
Probiotics a Potential
Treatment for Mental Illness - Medscape, 11/19/13 -
"although human studies are still largely lacking, they did find some with
promising results on behavior, including 1 showing that healthy volunteers who
received Lactobacillus helveticus R0052 plus B longum for 30 days reported
significantly lower stress levels than those who received placebo, as well as
significantly reduced urinary free cortisol levels ... Another study of 124
volunteers (mean age, 61.8 years) showed that those who consumed
probiotic-containing yogurt for 3 weeks had significantly improved mood compared
with those who received placebo ... the term "psychobiotic" was created as
recent studies have begun to explore a possible link between probiotics and
behavior ... As a class of probiotic, these bacteria are capable of producing
and delivering neuroactive substances such as gamma-aminobutyric acid [GABA] and
serotonin, which act on the brain-gut axis ... a study of human patients with
chronic fatigue syndrome showed that those who consumed an active strain of L
casei 3 times a day had significantly higher improvement scores on anxiety
measures than did those who received matching placebo"
-
Are
probiotics a promising treatment strategy for depression? - Science Daily,
11/14/13 - "Human studies are still largely lacking, but
a few have shown promising results. In one, healthy volunteers received either a
probiotic combination (L.. helveticus R0052 and B. longum) or placebo for 30
days. Those who received the probiotics reported lower stress levels. In a
separate study, volunteers who consumed a yogurt containing probiotics reported
improved mood"
-
Microbes
in the Gut Help Determine Risk of Tumors - Science Daily, 11/5/13 -
"Known risk factors for developing colorectal cancer
include consuming a diet rich in red meat, alcohol consumption, and chronic
inflammation in the gastrointestinal tract ... mice given the microbiota of the
tumor-bearing mice had more than two times as many colon tumors as the mice
given a healthy microbiota ... In all these [mouse] models the inflammation is
critical, but so is the change in the communities ... We liken it to a
feed-forward type mechanism where the inflammation is changing the community and
the community is inducing inflammation. They make each other worse to the point
that you have higher rates of tumor formation"
-
Intestinal Bacteria Linked to Rheumatoid Arthritis - Science Daily, 11/5/13
- "add to the growing evidence that the trillions of
microbes in our body play an important role in regulating our health ... the
researchers found that P. copri was more abundant in patients newly diagnosed
with rheumatoid arthritis than in healthy individuals or patients with chronic,
treated rheumatoid arthritis. Moreover, the overgrowth of P. copri was
associated with fewer beneficial gut bacteria belonging to the genera
Bacteroides" - Note: It's one more thing to think about when you ask
your doctor for antibiotics for that sore throat or cold.
-
The Role of the Gut
Microbiome in Health and Disease - Medscape, 11/5/13 -
"Disturbances to the microbial equilibrium of the gut
may mean that some microbes become overrepresented while others are diminished.
"It's like a garden—you're less likely to have weeds growing if you have lush
vegetation, but without this vegetation the weeds can potentially take over,"
Mazmanian says. When the gut moves toward a state of microbial imbalance,
normally benign gut microbes may begin to induce inflammation and trigger
disease throughout the body, even in the nervous system ... although 70% of the
immune cells in the body at any one time can be found in the intestine, they
circulate throughout the body, and the microbiota of the gut environment help
determine how immune cells will behave elsewhere. He gives an example: "If
T-cells, while in the gut, are programmed by the microbiota to have
anti-inflammatory properties, then they may suppress inflammation even after
they leave the gut."" - See
probiotic products at Amazon.com.
-
Mesalazine and/or
Probiotics for Diverticular Disease - Medscape, 10/16/13 -
"Group M (active mesalazine 1.6 g/day plus Lactobacillus
casei subsp. DG placebo), Group L (active Lactobacillus casei subsp. DG 24
billion/day plus mesalazine placebo), Group LM (active Lactobacillus casei
subsp. DG 24 billion/day plus active mesalazine), Group P (Lactobacillus casei
subsp. DG placebo plus mesalazine placebo). Patients received treatment for 10
days/month for 12 months ... Recurrence of SUDD occurred in no (0%) patient in
group LM, in 7 (13.7%) patients in group M, in 8 (14.5%) patients in group L and
in 23 (46.0%) patients in group P (LM group vs. M group, P = 0.015; LM group vs.
L group, P = 0.011; LM group vs. P group, P = 0.000; M group vs. P group, P =
0.000; L group vs. P group, P = 0.000). Acute diverticulitis occurred in six
group P cases and in one group L case"
-
Probiotics’ benefits go beyond digestion - Washington Post, 10/15/13 -
"We hear about them everywhere — how they clear up
everything from a bloated gut to a depressed mind. How they boost the immune
system and improve skin health. How they delay allergies in children and prevent
urinary tract infections in women ... Probiotics come in many forms, and they
don’t need to be delivered through yogurt — particularly important for the
dairy-intolerant. Probiotics can be found as fresh, refrigerated supplements at
some health food stores, as well as dried and preserved ... the probiotics
thrive best when prebiotics are present. Prebiotics, which are found in such
foods as whole grains, bananas and onions, are nondigestible carbohydrates that
create a probiotic-friendly gut environment ... The appropriate probiotic
dosage, according to McCusker, is about 5 billion units for daily health
maintenance and 15 billion-20 billion when you are treating a specific
condition" - See
probiotic products at Amazon.com.
-
Lactobacillus Probiotics
May Prevent Recurrent UTIs - Medscape, 9/20/13 -
"randomised double-blind non-inferiority trial comparing lactobacilli to
trimethoprim–sulfamethoxazole (TMP-SMX) in 252 postmenopausal women with a
history of at least three self-reported symptomatic UTIs within the preceding
year ... After 12 months of prophylaxis, the mean number of clinical UTI
recurrence (CR) was 2.9 in the TMP-SMX group and 3.3 in the lactobacilli group
(p=0.42). The mean number of microbiological recurrence (MR) was significantly
less in TMP-SMX group at 1.2 compared with 1.8 in the lactobacilli group
(p=0.02). For both CR and MR, a higher proportion of women in the lactobacilli
group experienced at least one UTI recurrence and the median time to first
recurrence was significantly shorter in the lactobacilli group. In women with
complicated UTIs, the mean number of CRs was 4.4 in the TMP-SMX group compared
with 3.4 in the lactobacilli group (p<0.001), suggesting a favourable effect of
lactobacilli in this subgroup. With regard to adverse events, there were no
significant differences between groups, although the lactobacilli group had a
non-significantly higher number of treatment-related withdrawals with
gastrointestinal side effects being the most common"
-
The best foods for clear skin - washingtonpost.com, 9/18/13 -
"Stay away from anything that comes in a box ... both
because of the added sugars and because of other additives ... gobble up produce
of all colors, plus nuts and seeds, to get minerals, fiber and vitamins A, C and
E ... Foods that keep your blood sugar low are also good for the skin ... avoid
sugar ... omega-3 fatty acids, which are found in wild salmon, help support
healthy cell membranes ... Another smart move is the addition into the diet of
probiotics, which can be found in yogurt and kefir as well as nutritional
supplements. (She prefers supplements over yogurt because they contain much
higher amounts of probiotics.)"
-
Gut
Microbes Closely Linked to Proper Immune Function, Other Health Issues -
Science Daily, 9/16/13 - "Problems ranging from
autoimmune disease to clinical depression and simple obesity may in fact be
linked to immune dysfunction that begins with a "failure to communicate" in the
human gut ... Health care of the future may include personalized diagnosis of an
individual's "microbiome" to determine what prebiotics or probiotics are needed
to provide balance ... Appropriate sanitation such as clean water and sewers are
good. But some erroneous lessons in health care may need to be unlearned --
leaving behind the fear of dirt, the love of antimicrobial cleansers, and the
outdated notion that an antibiotic is always a good idea. We live in a world of
"germs" and many of them are good for us"
-
Gut Bacteria From Thin Humans Can Slim Mice Down - NYTimes.com, 9/5/13 -
"Researchers found pairs of human twins in which one was
obese and the other lean. They transferred gut bacteria from these twins into
mice and watched what happened. The mice with bacteria from fat twins grew fat;
those that got bacteria from lean twins stayed lean ... The investigators
discovered that given a chance, and in the presence of a low-fat diet, bacteria
from a lean twin will take over the gut of a mouse that already had bacteria
from a fat twin. The fat mouse then loses weight. But the opposite does not
happen. No matter what the diet, bacteria from a fat mouse do not take over in a
mouse that is thin ... The fat mice that got food high in fat and low in fruits
and vegetables kept the gut bacteria from the fat twins and remained fat. The
thin twins’ gut bacteria only took over when the mice got pellets that were rich
in fruits and vegetables and low in fat" - [WebMD
/
ABC News]
-
Why
Smokers Gain Weight When They Quit Smoking: Changes in Intestinal Flora -
Science Daily, 8/29/13 - "the Swiss IBD cohort study
examined the genetic material of intestinal bacteria found in the faeces and
studied stool samples which they had received from twenty different persons over
a period of nine weeks -- four samples per person. The test persons included
five non-smokers, five smokers and ten persons who had quit smoking one week
after the start of the study ... While the bacterial diversity in the faeces of
smokers and non-smokers changed only little over time, giving up smoking
resulted in the biggest shift in the composition of the microbial inhabitants of
the intestines. The Proteobacteria and Bacteroidetes fractions increased at the
expense of representatives of the Firmicutes and Actinobacteria phyla. At the
same time, the test subjects who had quit smoking gained an average of 2.2 kilos
in weight although their eating and drinking habits remained the same ... Their
results reflected those seen in previous studies conducted with mice"
-
Obesity
and diabetes risk: One in four has alarmingly few intestinal bacteria, Danish
study finds - Science Daily, 8/28/13 - "Oluf
Pedersen compares the human gut and its bacteria with a tropical rainforest. He
explains that we need as much diversity as possible, and -- as is the case with
the natural tropical rainforests -- decreasing diversity is a cause for concern.
It appears that the richer and more diverse the composition of our intestinal
bacteria, the stronger our health. The bacteria produce vital vitamins, mature
and strengthen our immune system and communicate with the many nerve cells and
hormone-producing cells in the intestinal system. And, not least, the bacteria
produce a wealth of bioactive substances which penetrate into the bloodstream
and affect our biology in countless ways ... people having few and less diverse
intestinal bacteria are more obese than the rest. They have a preponderance of
bacteria which exhibit the potential to cause mild inflammation in the digestive
tract and in the entire body, which is reflected in blood samples that reveal a
state of chronic inflammation, which we know from other studies to affect
metabolism and increase the risk of type 2 diabetes and cardiovascular diseases"
-
Probiotics Prevent Diarrhea Related to Antibiotic Use, Review Shows -
Science Daily, 5/30/13 - "Antibiotics disturb the
beneficial bacteria that live in the gut and allow other harmful bacteria like
C. difficile to take hold. Although some people infected with C. difficile show
no symptoms, others suffer diarrhea or colitis. The so-called "good bacteria" or
yeast in probiotic foods and supplements may offer a safe, low-cost way to help
prevent C. difficile-associated diarrhea (CDAD). This finding is important
because CDAD is expensive to treat ... Probiotics taken in conjunction with
antibiotics reduced the number of people who suffered diarrhea by 64%"
-
Changing
Gut Bacteria Through Diet Affects Brain Function - Science Daily, 5/28/13 -
"Time and time again, we hear from patients that they
never felt depressed or anxious until they started experiencing problems with
their gut ... Researchers divided the women into three groups: one group ate a
specific yogurt containing a mix of several probiotics -- bacteria thought to
have a positive effect on the intestines -- twice a day for four weeks; another
group consumed a dairy product that looked and tasted like the yogurt but
contained no probiotics; and a third group ate no product at all ... compared
with the women who didn't consume the probiotic yogurt, those who did showed a
decrease in activity in both the insula -- which processes and integrates
internal body sensations, like those form the gut -- and the somatosensory
cortex during the emotional reactivity task ... Further, in response to the
task, these women had a decrease in the engagement of a widespread network in
the brain that includes emotion-, cognition- and sensory-related areas. The
women in the other two groups showed a stable or increased activity in this
network"
-
Probiotics found to reduce hepatic encephalopathy - Science Daily, 4/25/13 -
"Ammonia, produced by gut bacteria, is thought to be one
of the main mediators of cerebral dysfunction in HE. Probiotics work by
enriching the gut flora with a non-urease producing microorganisms, which
decrease ammonia production ... Twice as many patients taking a placebo
developed overt HE (the study's primary endpoint) compared to patients taking
probiotics in the form of a capsule ... Hepatic encephalopathy is an insidious
disease that's caused by an accumulation of toxins in the blood that are
normally removed by the liver ... Hepatic encephalopathy is a spectrum of
neuropsychiatric abnormalities including personality changes, intellectual
impairment and reduced levels of consciousness in patients with liver failure,
after exclusion of other known brain disease" - See
Garden of Life, Primal Defense at Amazon.com. Note: Maybe
it will work for ammonia accumulation due to endurance exercise:
-
Ammonia accumulation during highly intensive long-lasting cycling:
individual observations - Int J Sports Med. 1990 May;11 Suppl 2:S78-84 -
"Acute quantitative ammonia production during
intensive endurance exercise may be enhanced by a reduced glycogen
availability in muscle. However, adequate amounts of glycogen itself do not
prevent ammonia production when exercise is at high intensity and
long-lasting. The continuous ammonia accumulation in blood during endurance
exercise in trained individuals may be the result of a relatively low blood
flow to the liver and thereby low clearance in contrast to lactate which may
not accumulate due to a high clearance rate in both active and nonactive
oxidative muscle fibers. In a number of subjects it was observed that
exhaustion, when performing endurance exercise at high exercise intensities,
occurred when plasma ammonia levels were high. Muscle cramps occurred in
subjects who reached their highest individual ammonia values and seemed not
to be related to serum potassium, plasma lactate, or muscle glycogen. These
individual observations give rise to the hypothesis that high intramuscular
ammonia levels may be related to the etiology of muscle exhaustion and
muscle cramping during highly intensive endurance exercise"
-
Probiotics reduce stress-induced intestinal flare-ups, study finds - Science
Daily, 3/14/13 - "while stress does not cause IBS, it
does alter brain-gut interactions and induces the intestinal inflammation that
often leads to severe or chronic belly pain, loss of appetite and diarrhea ...
Stress has a way of suppressing an important component called an inflammasome
which is needed to maintain normal gut microbiota, but probiotics reversed the
effect in animal models ... The effect of stress could be protected with
probiotics which reversed the inhibition of the inflammasome"
-
Natural
Probiotic for Osteoporosis? Building Healthy Bones Takes Guts - Science
Daily, 2/14/13 - "inflammation in the gut can cause bone
loss, though it's unclear exactly why ... the researchers fed the mice
Lactobacillus reuteri, a probiotic known to reduce inflammation, a sometimes
harmful effect of the body's immune response to infection ... the male mice
showed a significant increase in bone density after four weeks of treatment.
There was no such effect when the researchers repeated the experiment with
female mice, an anomaly they're now investigating ... People tend to think of
osteoporosis as just affecting postmenopausal women, but what they don't realize
is that it can occur with other conditions such as inflammatory bowel disease
and Type 1 diabetes ... You don't want to put your child on medications that
reduce bone remodeling for the rest of their life, so something natural could be
useful for long-term treatment of bone loss that begins at childhood"
-
Gut
Bacteria Linked to Cholesterol Metabolism - Science Daily, 2/18/13 -
"gut bacteria reduce bile acid synthesis in the liver by
signaling through a specific protein, known as the FXR receptor, in the small
intestine ... The FXR receptor not only affects cholesterol metabolism but is
also involved in the body's sugar and fat metabolism ... If future research can
identify the specific bacteria that affect FXR signaling in the gut, this could
lead to new ways to treat diabetes and cardiovascular disease"
-
Effects
of antibiotics on gut flora analyzed - Science Daily, 1/9/13 -
"In the gut live one trillion bacteria, which are known
as microbiota or gut flora, and that have co-evolved in symbiosis with humans.
According to this study, treatment with antibiotics can alter this symbiosis
from early stages of the treatment. "Although some of the changes are
oscillatory and can be reversed at the end of the treatment, others seem
irreversible,""
-
Metabolic Diseases
and Pro- and Prebiotics - Medscape, 11/7/12 -
"Recent findings that support the idea of the involvement of intestinal bacteria
in the development of obesity and diabetes include: 1) the resistance to
high-fat diet-induced obesity in germ-free mice,[64] 2) antibiotic-induced
reduction of plasma LPS levels in obese mice fed a high-fat diet,[65] and 3)
delayed onset and development of type 1 diabetes by use of antibiotics in a
diabetes-prone rat model ... The control of intestinal microbial composition by
use of probiotics and prebiotics is likely to impact the development of
metabolic diseases through modulation of immune responses/inflammation and
metabolism. Supplementation of probiotics and prebiotics may delay and/or
reverse the progression of metabolic diseases"
-
Daily
doses of a new probiotic reduces 'bad' and total cholesterol - Science
Daily, 11/5/12 - "The study involved 127 adult patients
with high cholesterol. About half the participants took L. reuteri NCIMB 30242
twice a day, while the rest were given placebo capsules ... Those taking the
probiotic had LDL levels 11.6 percent lower than those on placebo after nine
weeks. Furthermore, cholesterol esters were reduced by 6.3 percent and
cholesterol ester saturated fatty acids by 8.8 percent, compared with the
placebo group ... Furthermore, people taking the probiotic had total cholesterol
reduced by 9.1 percent. HDL "good" cholesterol and blood triglycerides, a
dangerous form of fat in the blood, were unchanged ... Scientists have proposed
that Lactobacillus bacteria alone may impact cholesterol levels in several ways,
including breaking apart molecules known as bile salts. L. reuteri NCIMB 30242
was fermented and formulated to optimize its effect on cholesterol and bile
salts ... the study results suggest the probiotic broke up bile salts, leading
to reduced cholesterol absorption in the gut and less LDL ... The probiotic
worked at doses of just 200 milligrams a day, far lower than those for soluble
fiber or other natural products used to reduce cholesterol"
-
Probiotics are secret weapon for fighting symptoms of the common cold in college
students, study suggests - Science Daily, 10/22/12 -
"randomized 198 college students aged 18 to 25 and living on-campus in residence
halls at Framingham State University in Massachusetts. Groups received either a
placebo (97 students) or a powder blend containing Chr. Hansen's probiotic
strains BB-12® and LGG® (101 students) for 12 weeks. Each day, students
completed a survey to assess the effect of the probiotic supplementation ... The
study found that while all students caught colds at roughly the same rate, the
students who took the probiotic supplementation experienced: ... A duration of
colds that was two days shorter (four days vs. six days) ... Symptoms that were
34% less severe and ... A higher quality of life that resulted in fewer missed
school days (15 vs. 34 missed by students taking the placebo) ... consumers need
to read the label to be sure that the product contains Lactobacillus rhamnosus
GG [LGG] and Bifidobacterium animalis lactis BB12 [BB12]. There also are some
yogurts that contain LGG and/or BB12 but check the labels, since companies
change the probiotics strains often"
-
Chronic
kidney disease alters intestinal microbial flora - Science Daily, 10/9/12 -
"consumption of high-fiber foods and better control of
uremia -- a disease common in kidney failure -- by diet and dialysis may improve
the composition of gut microbes and the well-being of patients ... They found
marked differences in the abundance of some 190 types of bacteria in the gut
microbiome of those with kidney disease -- and confirmed the results in a
concurrent study of rats with and without chronic kidney disease ... One
solution, Vaziri said, is to provide longer, more frequent dialysis treatments.
This would let more potassium be removed by dialysis and allow for more
potassium in the diet. Alternatively, packaged fiber foods that do not contain
potassium could be used as a dietary supplement" - See
Garden of Life, RAW Fiber at Amazon.com.
-
Gut
bacteria could could play key role in development of type 2 diabetes -
Science Daily, 9/26/12 - "The 1.5 kilograms of bacteria
that we each carry in our intestines have an enormous impact on our health and
well being. The bacteria normally live in a sensitive equilibrium but if this
equilibrium is disrupted our health could suffer. In the new study, scientists
examined the intestinal bacteria of 345 people from China, of which 171 had type
2 diabetes ... The research, which was recently published in the scientific
journal Nature, also demonstrated that people with type 2 diabetes have a more
hostile bacterial environment in their intestines, which can increase resistance
to different medicines ... The big question now is whether the changes in gut
bacteria can affect the development of type 2 diabetes or whether the changes
simply reflect that the person is suffering from type 2 diabetes" -
Follow-up story:
-
Natural
intestinal flora strengthen immune system - Science Daily, 7/2/12 -
"The research team infected two groups of mice with
various viral germs. One group had a normal intestinal flora and the other
consisted of so-called axenic mice, which do not have any intestinal flora due
to having been treated with antibiotics or bred under particularly clean
conditions. The immune response in the axenic mice was greatly reduced and led
the disease to take a more severe course than in the healthy mice. When the
scientists artificially provided the axenic mice with a healthy intestinal
flora, their immune response improved ... The team succeeded in demonstrating
that signals from the intestinal bacteria lead to a conditioning of the
dendritic cells. This conditioning takes place on the level of the DNA in the
nucleus and enables genes that encode these soluble mediators to be read better.
The scientists speak of epigenetic changes. "This is the first time anyone has
shown that changes in the natural intestinal flora resulting from antibiotics,
hygiene, or lifestyle can have substantial consequences for the entire immune
system," says Diefenbach"
-
Early
gut bacteria regulate happiness - Science Daily, 6/12/12 -
"UCC scientists have shown that brain levels of
serotonin, the 'happy hormone' are regulated by the amount of bacteria in the
gut during early life ... normal adult brain function depends on the presence of
gut microbes during development. Serotonin, the major chemical involved in the
regulation of mood and emotion, is altered in times of stress, anxiety and
depression and most clinically effective antidepressant drugs work by targeting
this neurochemical ... Scientists at the Alimentary Pharmabiotic Centre in UCC
used a germ-free mouse model to show that the absence of bacteria during early
life significantly affected serotonin concentrations in the brain in adulthood
... Finally, when the scientists colonized the animals with bacteria prior to
adulthood, they found that many of the central nervous system changes,
especially those related to serotonin, could not be reversed indicating a
permanent imprinting of the effects of absence of gut flora on brain function"
-
New
approach to regulating probiotics recommended - Science Daily, 5/24/12 -
"the regulatory system in the US maintains that any
product that claims to impact disease must be categorized as a drug. Therefore,
scientists can't test if a probiotic yogurt relieves patients with inflammatory
bowel disease without first registering the yogurt as a drug ... this regulation
has halted a lot of great research on probiotics in North America and has
ramifications for probiotic research and development in Europe"
-
Probiotics Reduce Antibiotic Diarrhea - Science Daily, 5/8/12 -
"Diarrhea is a common side effect of antibiotic use,
occurring in almost 1 in 3 people who take the drugs ... By affecting good
bacteria, as well as bad, antibiotics can disrupt the delicate microbial balance
in the intestines, but the live microorganisms marketed as probiotics can help
restore this balance to reduce diarrhea risk ... in people taking antibiotics,
those who used probiotics were 42% less likely to develop diarrhea"
-
Invisible helpers: How probiotic bacteria protect against inflammatory bowel
diseases - Science Daily, 4/26/12 - "In experiments
with mice, the scientists observed that lactocepin -- an enzyme produced from
the lactic acid bacterium Lactobacillus paracasei -- can selectively interrupt
inflammatory processes. As the scientists observed, lactocepin degrades
messengers from the immune system, known as chemokines, in the diseased tissue.
As a part of the "normal" immune response, chemokines are needed to guide
defense cells to the source of the infection. In chronic intestinal disorders
like Crohn's disease and ulcerative colitis, the otherwise highly effective
defense mechanism against infectious agents is malfunctioning. Chemokines such
as "IP-10" then contribute to the tissue damage due to chronic inflammatory
processes, preventing the tissue from healing"
-
Probiotic Effects in
Infants Last Until 4 Years of Age - Medscape, 2/10/12 -
"Infants exposed to Lactobacillus rhamnosus through diet
supplements from 35 weeks' gestation through 2 years of age had a significantly
lower risk for eczema and rhinoconjunctivitis. The protective effect lasted
until the children were at least 4 years of age"
-
New
evidence that bacteria in large intestine have a role in obesity - Science
Daily 12/21/11 [but it showed up in the news on 12/28] -
"trillions of bacteria live in the large intestine of healthy people, where they
help digest food and make certain vitamins. In recent years, however, scientists
have realized that these bacteria do more -- they interact with the rest of the
body in ways that affect the use of energy and its storage as fat and finely
tune the immune system. Claus and Nicholson decided to see how intestinal
bacteria might affect the activity of brown fat. The "good" fat that burns
calories quickly before they can be stored as fat, brown fat exists in small
deposits in the neck area and elsewhere -- not like "white fat" in flab around
the waist and buttocks ... the scientists uncovered evidence suggesting that the
bacteria do influence the activity of brown fat"
-
Probiotics reduce infections for patients in intensive care, study finds -
Science Daily, 12/1/11 - "including probiotics with
nutrients, supplied via the patient's feeding tube, increased interferon levels,
reduced the number of infections, and even reduced the amount of time patients
spent in intensive care ... by day 15 the patients who received the probiotics
had significantly higher levels of both IL-12 and IFNy than the control
patients. They also showed a decrease in the Th2-associated factors IL-4 and
IL-10 ... probiotic therapy reduced the number of infections occurring after
seven days, reduced the number of different antibiotics needed to treat
infections, and shortened the length of time the patients were required to stay
in ICU"
-
Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism
warrants further investigation - Science Daily, 11/16/11 -
"The major finding: in the small intestine, higher than
normal numbers of the newly discovered bacterium, "commensal rat ileum
bacterium" (CRIB) were correlated with reduced severity of acute pancreatitis in
animals that had been fed probiotic. These animals had less infection of remote
organs, less infection of dying and dead pancreatic tissues, and less severe
immune response during acute pancreatitis, as demonstrated by lower plasma
levels of proinflammatory cytokines"
-
Probiotic protects intestine from radiation injury - Science Daily, 11/16/11
- "the therapy can kill both cancer cells and healthy
ones, leading to severe bouts of diarrhea if the lining of the intestine gets
damaged ... For many patients, this means radiation therapy must be
discontinued, or the radiation dose reduced, while the intestine heals ...
Probiotics may provide a way to protect the lining of the small intestine from
some of that damage ... the probiotic bacteria Lactobacillus rhamnosus GG (LGG),
among other Lactobacillus probiotic strains, protected the lining of the small
intestine in mice receiving radiation ... the probiotic was effective only if
given to mice before radiation exposure ... The bacteria we use is similar to
what's found in yogurt or in commercially available probiotics ... So
theoretically, there shouldn't be risk associated with this preventative
treatment strategy any more than there would be in a patient with abdominal
cancer eating yogurt"
-
Some Probiotics Effectively
Reduce Common GI Symptoms - Medscape, 11/8/11 -
"Mounting evidence is building a strong case for the use of probiotics, or
"good" bacteria, to alleviate common gastrointestinal (GI) symptoms, such as
diarrhea, bloating, and inflammation, according to several studies highlighted
during a press briefing here at the American College of Gastroenterology 2011
Annual Scientific Meeting and Postgraduate Course ... By giving a specific
probiotic orally, we could actually reduce the levels of these proinflammatory
cytokines and actually enhance the production of an anti-inflammatory cytokine,
which is the exact replication of what we identified in animal models and more
basic models ... Plasma levels of the anti-inflammatory cytokine interleukin
(IL)-10 rose significantly in healthy volunteers and patients with psoriasis,
but not in those who took the placebo for 8 weeks ... Plasma levels of 2
proinflammatory cytokines — tumor necrosis factor-alpha and IL-6 — dropped in
all patients who received B infantis. C-reactive protein levels were also
significantly lower in patients with psoriasis, ulcerative colitis, and chronic
fatigue after treatment with the bacterium than after treatment with placebo"
-
Some Doctors Warming Up to Probiotics - WebMD, 11/4/11 -
"A review of 22 studies involving 3,096 patients
presented at the meeting showed that taking probiotics while on antibiotics may
cut the risk of developing antibiotic-associated diarrhea by about 60%
...antibiotics kill "good" bacteria along with the bacteria that cause illness.
A decrease in beneficial bacteria may lead to digestive problems. Taking
probiotics may help replace the lost beneficial bacteria and help prevent
diarrhea ... Probiotics also appeared to provide protection against potentially
deadly bouts of diarrhea caused by the bug Clostridium difficile, or C. diff.
... Look for a brand you trust and whose label offers that information"
-
Gut
bacteria may affect whether a statin drug lowers cholesterol - Science
Daily, 10/13/11 - "Among the group who had a strong
response to the drug, three bile acids appeared to play a role. The bile acids
are produced by certain gut bacteria, which are increasingly understood as
factories for chemicals that can contribute to a state of health. Among the
people who responded poorly to the statin, five different bile acids were
commonly evident ... new strategies could be developed to manipulate the gut
microbiome using probiotics to spur different gut bacteria, which could then
give the drugs a boost"
-
Probiotic intake linked to fewer birth complications - Nutra USA, 9/13/11 -
"The Norwegian researchers analyzed data from 33,399
women participating in the Norwegian Mother and Child Cohort Study ... The
intake of lactobacilli-containing milk-based products was determined using a
food frequency questionnaire, while pre-eclampsia was determined using the
Norwegian Medical Birth Registry ... the daily intake of at least 140 mL of
probiotic milk products was associated with a 20% reduced risk of pre-eclampsia
... The effects were more pronounced for severe pre-eclampsia, with daily and
weekly intakes of probiotic products associated with a 39% and 25%,
respectively" - [Abstract]
-
New
polymer research could boost probiotics industry - Science Daily, 9/5/11 -
"One of the challenges for manufacturers of probiotic
foods is getting high enough numbers of these bacteria into the intestines; most
perish under the heavy acidic conditions of the stomach ... The novel biopolymer
is completely biodegradable and is able to remain intact in the stomach and
continue to the intestine, where it disintegrates, releasing the bacteria ...
The researchers believe their findings could have a major impact on the
probiotics industry"
-
Mind-altering microbes: Probiotic bacteria may lessen anxiety and depression
- Science Daily, 8/29/11 - "Probiotic bacteria have the
potential to alter brain neurochemistry and treat anxiety and depression-related
disorders ... mice fed with Lactobacillus rhamnosus JB-1 showed significantly
fewer stress, anxiety and depression-related behaviours than those fed with just
broth. Moreover, ingestion of the bacteria resulted in significantly lower
levels of the stress-induced hormone, corticosterone ... regular feeding with
the Lactobacillus strain caused changes in the expression of receptors for the
neurotransmitter GABA in the mouse brain, which is the first time that it has
been demonstrated that potential probiotics have a direct effect on brain
chemistry in normal situations"
-
Antibiotic Overuse May Be Bad for Body's Good Bacteria - WebMD, 8/24/11 -
"Antibiotic overuse doesn’t just lead to drug-resistant
superbugs, it may also permanently wipe out the body’s good bacteria ... in a
developed country like the U.S., the average child gets 10 to 20 courses of
antibiotics by age 18 ... doctors often prescribe antibiotics before they know
whether an infection is viral or bacterial. If the problem is a virus,
antibiotics don't help ... a 2003 study published in the Journal of the American
Medical Association showed that doctors prescribed antibiotics for more than 60%
of adults with upper respiratory tract infections, which are usually caused by
viruses ... Antibiotics, he thinks, may also be contributing to obesity in
humans, though Blaser says no one yet understands how ... a child’s risk for
inflammatory bowel disease increases with the number of courses of antibiotics
taken ... antibiotics may be a factor behind the unexplained rises in allergies,
asthma, and type 1 diabetes in children ... There’s really only a limited number
of studies that have been done on this so far, but I think we’re going to see
more because I think it’s going to be a big deal for us to understand this ...
effective probiotics are needed to replace lost good bacteria"
-
A
gut-full of probiotics for your neurological well-being - Science Daily,
7/5/11 - "A recent study in mice, for example, showed
that the presence of neurochemicals such a serotonin in the bloodstream was due
to direct uptake from the gut ... Until recently the idea that probiotic
bacteria administered to the intestine could influence the brain seemed almost
surreal ... Yet in Lyte's paper the concept is supported by studies showing that
microbes can produce and respond to neurochemicals, which can induce
neurological and immunological effects on the host ... The research presents an
idea for selecting probiotic strains with neurological applications and linking
this with immune-modulatory effects, while highlighting the fact that microbial
strains already being widely ingested in fermented food can produce
neurochemicals" - See
Garden of Life, Primal Defense at Amazon.com.
-
‘Level 1’ evidence that probiotics boost ‘transit time’: Danisco & Fonterra
- Nutra USA 6/22/11 - "the benefits were “at least
equivalent to that of dietary fiber” ... The researchers recruited 100 healthy
people with an average age of 44 and randomly assigned them to receive high or
low daily doses of B. lactis HN019, or placebo for 14 days. High dose was
defined as 17.2 billion colony forming units (CFU), while the low dose was 1.8
billion CFU ... At the end of the study results showed an improvement in transit
time in the high dose group of 33 percent, and 25 percent in the low dose group.
There was no change in the placebo group, added the researchers" - [Abstract]
-
Prebiotics may keep students healthy during stressful periods - Nutra USA,
5/26/11 - "A daily dose of 5.0 grams of the commercially
available Purimmune prebiotic product from GTC Nutrition was associated with a
40 percent reduction in the number of days with cold or flu, according to
findings published in the American Journal of Clinical Nutrition ... In
addition, the prebiotic supplement – based on galactooligosaccharides – was also
associated with a reduction in the occurrence of gut upsets in students around
the time of fall final exams" - [Abstract]
- See
galactooligosaccharide products at iHerb
(see the abstract). I could have used that in college. I remember that it
worked out that I had two or three finals on the same day and I was up late
studying for all three and got a stomach ache so bad I had to go to the campus
nurse. I never got much studying done but made it through the exams OK.
-
Healthy
gut flora could prevent obesity, rat study suggests - Science Daily, 5/25/11
- "Poor gut flora is believed to trigger obesity. In the
same way, healthy gut flora could reduce the risk. This has shown to be the case
in tests on rats. Daily intake of a lactic acid bacteria, which has been given
the name Lactobacillus plantarum HEAL19, appears to be able to prevent obesity
and reduce the body's low-level inflammation ... Rats who were given this
specific lactic acid bacterium from their time in the uterus up to adult age put
on significantly less weight than other rats. Both groups ate the same amount of
high-energy food ... A third group of rats were given the inflammation-causing
Escherichia coli bacteria in their drinking water, in addition to the same
high-energy food as the other rats. The E. coli supplement led to changes in gut
flora and increased body fat ... A healthy gut flora at an early stage appears
to play a part in children's wellbeing later in life"
-
Comfort
food: Protein from probiotic bacteria may alleviate inflammatory bowel disorders
- Science Daily, 5/23/11 - "A protein isolated from
beneficial bacteria found in yogurt and dairy products could offer a new, oral
therapeutic option for inflammatory bowel disorders (IBD) ... the protein
supports intestinal epithelial cell growth and function, and reduces
inflammatory responses that can cause intestinal cells to die. Importantly, the
investigators showed that oral consumption of p40 by mice in a protective
delivery system prevents and treats colitis in multiple models of the disease
... Many of the hundreds of bacterial species that live in our gut (known as the
"human microbiome") are helpful to us: they help us digest certain substances,
produce vitamins and fight off more dangerous bacteria. But miscommunication
between these bacteria and our gut lining can lead to conditions like ulcerative
colitis and Crohn's disease"
-
Gut
bacteria linked to behavior: That anxiety may be in your gut, not in your
head - Science Daily, 5/17/11 - "For each
person, the gut is home to about 1,000 trillium bacteria with which we live
in harmony. These bacteria perform a number of functions vital to health:
They harvest energy from the diet, protect against infections and provide
nutrition to cells in the gut. Any disruption can result in life-threatening
conditions, such as antibiotic-induced colitis from infection with the
"superbug" Clostridium difficile ... Working with healthy adult mice, the
researchers showed that disrupting the normal bacterial content of the gut
with antibiotics produced changes in behaviour; the mice became less
cautious or anxious. This change was accompanied by an increase in brain
derived neurotrophic factor (BDNF), which has been linked, to depression and
anxiety ... When oral antibiotics were discontinued, bacteria in the gut
returned to normal. "This was accompanied by restoration of normal behaviour
and brain chemistry,""
-
Probiotics may ease bowel movements for elderly: Study - Nutra USA,
5/13/11 - "The probiotic product (VSL
Pharmaceuticals) reportedly contained 450 billion viable lyophilized
bacteria from eight different strains, including Lactobacillus plantarum, L.
paracasei, L. bulgaricus, L. acidophilus, Bifidobacterium breve, B. longum,
B. infantis, and Streptococcus thermophilus ... people consuming the
probiotic experienced a lower incidence of diarrhea (60 percent lower),
compared to placebo ... In addition, laxative use decreased by 26 percent
amongst people in the probiotic group, compared to placebo, added the
Israeli scientists ... A significant reduction of Clostridium difficile
prevalence was found in the probiotic group" - [Abstract]
-
Probiotics may ease bloating for people with bowel disorders: Study -
Nutra USA, 5/12/11 - "Compared to results at the
start and end of the study, bloating symptoms were reduced by 15 percent in
the probiotic group"
-
C.
difficile colonization accompanied by changes in gut microbiota: Study hints
at probiotics as treatment - Science Daily, 4/19/11 -
"Asymptomatic colonization by Clostridium difficile,
absent the use of antibiotics, is common in infants and when it happens
changes occur in the composition of the gut microbiota ... The adult human
gut is an ecosystem containing several pounds of bacteria, including
hundreds of species and more than 100 trillion (100,000,000,000,000)
individuals. A healthy microbial ecosystem protects the host against
Clostridium difficile, which frequently colonizes the gut after its
ecological balance has been disrupted by broad spectrum antibiotics ... Our
results suggest that Bifidobacterium species, which are used as probiotics,
can participate in that barrier effect against C. difficile"
-
Antibiotics disrupt gut ecology, metabolism - Science Daily, 4/19/11 -
"carry several pounds of microbes in our
gastro-intestinal tracts. Recent research suggests that this microbial
ecosystem plays a variety of critical roles in our health ... antibiotics
profoundly disrupt intestinal homeostasis ... Intestinal microbes help us
digest our food, provide us with vitamins that we cannot make on our own,
and protect us from microbes that make us sick, amongst other things ...
administered antibiotics to the mice, to kill off most of their gut
microbiota, and analyzed the feces anew ... The levels of 87 percent of the
molecules detected had been shifted up or down by factors ranging from
2-fold to 10,000-fold ... the unnecessary use of antibiotics has deleterious
effects on human health that were previously unappreciated ... our gut
microbes control these important molecules raises the possibility that
manipulating these microbes could be used to modulate diseases that have
hormonal or metabolic origins (such as inmmunodeficiency, depression,
diabetes and others)"
-
Probiotic may reduce rate of recurrent urinary tract infections in women,
study suggests - Science Daily, 4/15/11 - "Of
the 100 women who participated in the study, 50 received LACTIN-V, and 50
received the placebo. Seven of the women who received LACTIN-V had at least
one urinary tract infection, compared to 13 in the placebo group"
-
Bacteria supplements may affect weight gain: Rat study extends
microflora-obesity link - Nutra USA, 4/12/11 -
"Early exposure to bacterial strains during pregnancy, breast feeding, and
early life has a profound impact on weight gain in the offspring, says a new
study with rats ... supplementation of a high-energy-dense diet with the
bacterial strain Lactobacillus plantarum resulted in less weight gain,
compared to rats fed only the high energy diet ... animals fed the high
energy diet and supplemented with less friendly Escherichia coli bacteria
experienced significantly higher levels of body fat, compared to the control
animals ... the L. plantarum supplemented animals had significantly lower
weight gain than both the control and E. coli-supplemented groups. This
difference was observed at birth (indicating a potential influence of the
mother’s diet) with the L. plantarum pups having an average birth weight of
7.5 grams, compared with 8.2 and 9.6 grams for the control and E.coli
animals, respectively ... After six months, a similar trend was observed,
with L. plantarum animals having an average weight of 304 grams, compared
with 340 and 352 grams for the control and E.coli animals, respectively"
- [Abstract]
-
'Knowing it in your gut' is real - Science Daily, 3/23/11 -
"the "cross-talk" between bacteria in our gut and our brain plays an
important role in the development of psychiatric illness, intestinal
diseases and probably other health problems as well including obesity ...
Using germ-free mice, Foster's research shows gut bacteria influences how
the brain is wired for learning and memory ... genes linked to learning and
memory are altered in germ-free mice and, in particular, they are altered in
one of the key brain regions for learning and memory -- the hippocampus ...
The take-home message is that gut bacteria influences anxiety-like behavior
through alterations in the way the brain is wired"
-
Gut
bacteria can control organ functions - Science Daily, 2/28/11 -
"The gut microbiota enhances the host's metabolic
capacity for processing nutrients and drugs and modulates the activities of
multiple pathways in a variety of organ systems ... Here we describe the
first evidence of an in vivo association between a family of bacteria and
hepatic lipid metabolism. These results provide new insights into the
fundamental mechanisms that regulate host-gut microbiota interactions and
are of wide interest to microbiological, nutrition, metabolic, systems
biology and pharmaceutical research communities ... Another important
finding in the paper, according to Claus, is that gut colonization strongly
stimulated the expression and activity of the cytochrome P450 3A11, an
essential enzyme in drug-detoxification pathways"
-
Probiotic identified to treat ulcers - Science Daily, 2/24/11 -
"H. pylori is considered one of the major risk
factors underlying the development of gastritis and gastric and duodenal
ulcers ... Currently, antibiotic-based treatment for H. pylori infection is
neither sufficient nor satisfactory, with the most successful treatments
reaching 75 to 90% eradication rates ... Among probiotics Bifidobacterium is
one of the favorite genera in studies focused on the prevention of
gastrointestinal infection and is often used in fermented dairy products or
food supplements ... They identified one strain (Bifidobacterium bifidum
CECT 7366) that under certain conditions had an inhibition level of nearly
95% in vitro and tested its activitity against infection in mi ... After 21
days, mice treated with the potentially probiotic strain developed
significantly less ulcers than the control group" - See
probiotics at Amazon.com.
-
Bacteria in the gut may influence brain development - Science Daily,
2/1/11 - "The research team compared behavior and
gene expression in two groups of mice -- those raised with normal
microorganisms, and those raised in the absence of microorganisms (or
germ-free mice). The scientists observed that adult germ-free mice displayed
different behavior from mice with normal microbiota, suggesting that gut
bacteria may have a significant effect on the development of the brain in
mammals"
-
New
probiotic combats inflammatory bowel disease - Science Daily, 1/31/11 -
"Northwestern Medicine researchers deleted a gene in
the probiotic Lactobacillus acidophilus and fed the new form to mice with
two different models of colitis. After 13 days of treatment, the novel
probiotic strain nearly eliminated colon inflammation in the mice and halted
progression of their disease by 95 percent ... In the study, the modified
Lactobacillus acidophilus entered the gut, which is akin to a battlefield of
friendly fire with immune cells attacking the intestine. The Lactobacillus
acidophilus acted as the gut's peacekeeping force, calming the
overstimulated immune cells ... The probiotic restored intestinal peace by
mobilizing messenger immune cells, called dendritic cells. The dendritic
cells, in turn, enhanced the production of other functional immune cells,
regulatory T-cells that rebalanced intestinal and systemic inflammation"
-
Specific populations of gut bacteria linked to fatty liver - Science
Daily, 1/31/11 - "A new research finding showing a
strong relationship between complex microbial ecologies in human intestines
and the common but serious medical condition known as fatty liver
illustrates this paradox ... Choline deficiency also implicates genetics,
since many people lack the genes to efficiently make choline internally ...
The implication of the finding is that these groups of bacteria may be
influencing the body's ability to properly use the choline available in food
... bioinformatics researchers at the University of North Carolina at
Charlotte found a strong correlation between the relative abundances of two
specific classes of bacteria and the development of fatty liver ... Those
patients with the highest abundance of Gammaproteobacteria at the beginning
of the study seemed to have the lowest fatty liver development. The ones
with the least developed the most fatty liver ... Erysipeoltrichi showed
exactly the opposite association, though this relationship was not quite as
strong. So there seemed to be change going on in opposite directions"
-
Synbiotics may protect kids from asthma: Danone study - Nutra USA,
1/12/11 -
"probiotics are defined as "live microorganisms which
when administered in adequate amounts confer a health benefit on the host".
Prebiotics are "nondigestible substances that provide a beneficial
physiological effect on the host by selectively stimulating the favourable
growth or activity of a limited number of indigenous bacteria". Synbiotics
are a combination of the two ... One year after the study, data was
available for 75 children, and this showed that the absolute risk of asthma
symptoms 'frequent wheezing' and 'wheezing and/or noisy breathing apart from
colds' were 20 and 28 percent lower, respectively, in the synbiotic group"
- [Abstract] - See
synbiotic products at Amazon.com.
-
Designer probiotics could reduce obesity - Science Daily, 12/22/10 -
"engineered a strain of Lactobacillus to produce a
version of a molecule called conjugated linoleic acid (CLA). When this
engineered bacterial strain was fed to mice, the researchers found that the
composition of the mice's fat tissue was significantly altered ... One type,
called t10, c12 CLA, has been shown to be associated with decreased body fat
in humans and other animals. t10, c12 CLA also has the ability to inhibit
the growth of colon cancer cells and induce their death. However, this type
of CLA is only produced by certain types of bacteria including
Propionibacterium acnes -- a skin bacterium that can cause acne ... In this
study, an enzyme-encoding gene from P. acnes was transferred to the
Lactobacillus strain allowing it to produce t10, c12 CLA ... CLA has already
been shown to alleviate non-alcoholic fatty liver disease that often
accompanies obesity. Therefore, increasing levels of CLA in the liver by
ingestion of a probiotic strain is of therapeutic relevance ... The same
group of researchers previously found that microbially produced CLA was able
to reduce the viability of colon cancer cells by 92%"
-
Dannon's Activia, DanActive health claims draw $21M fine - USATODAY.com,
12/15/10 - "Dannon will stop claiming that one daily
serving of Activia yogurt relieves irregularity and that DanActive helps
people avoid catching colds" - Here's the reason I used Activia to
make my own yoghurt (first bullet). This article doesn't address it. I
never did buy off on the irregularity claim but there might be some support
for colds:
-
Dannon Activia | How Activia Helps - Activia.com -
"This is where Activia, with Bifidus Regularis®,
can help! Activia is shown in several clinical studies to survive
passage through the digestive system and arrive in the gut in enough
quantities to help have a positive impact on slow intestinal transit"
-
Probiotics show potential against common cold: Study - Nutra USA 9/21/10
-
"daily consumption of Lactobacillus plantarum HEAL 9
(DSM 15312) and Lactobacillus paracasei 8700:2 (DSM 13434) reduced the
incidence of one or more episodes of the common cold from 67 percent in the
placebo group to 55 percent, according to findings published in the European
Journal of Nutrition ... Furthermore, the number of days of symptoms for the
cold was significantly reduced in people taking the probiotic supplements,
from an average of 8.6 to 6.2, compared with placebo ... the total symptom
score was reduced during the study period from a mean of 44.4 for the
control group to 33.6 for the probiotic group"
-
Probiotics shorten diarrhea episodes, review suggests - Science Daily,
11/9/10 - "Giving probiotics in conjunction with
rehydration fluids reduced the duration of diarrhea by around a day and
reduced the risk of diarrhea lasting four or more days by 59%"
-
Lactobacillus reuteri good for health, Swedish study finds - Science
Daily, 11/2/10 - "several different strains of
Lactobacillus reuteri have a positive effect on health, including various
types of gastrointestinal disorders and oral health. It is also believed
that lactobacilli play a role in the development of allergies ... Gabriela
Sinkiewicz has also studied how L. reuteri affects oral health and has
established that the occurrence of both plaque and bleeding from the gums
declined after only two weeks of using chewing gum containing certain
strains of L. reuteri"
-
Probiotics show potential against stress-related conditions - Nutra USA
10/29/10 - "Results showed that levels of
psychological distress, including measures of depression, anger-hostility,
anxiety, and problem solving, were significantly improved in the probiotic
group, compared with placebo" - [Abstract]
-
Probiotics show potential against common cold: Study - Nutra USA 9/21/10
-
"daily consumption of Lactobacillus plantarum HEAL 9
(DSM 15312) and Lactobacillus paracasei 8700:2 (DSM 13434) reduced the
incidence of one or more episodes of the common cold from 67 percent in the
placebo group to 55 percent, according to findings published in the European
Journal of Nutrition ... Furthermore, the number of days of symptoms for the
cold was significantly reduced in people taking the probiotic supplements,
from an average of 8.6 to 6.2, compared with placebo ... the total symptom
score was reduced during the study period from a mean of 44.4 for the
control group to 33.6 for the probiotic group" - [Abstract]
-
Cutting fat and calories can lower cancer risk in dogs and people -
Science Daily, 7/22/10 - "adding quality prebiotics
to pet foods can enhance their gut health"
-
Probiotics use in mothers limits eczema in their babies - Science Daily,
7/20/10 - "compared mothers who drank one glass of
probiotic milk a day to women who were given a placebo. Use of the probiotic
milk -- which the mothers drank beginning at week 36 in their pregnancy up
through to three months after birth -- reduced the incidence of eczema by 40
percent in children up to age two, the researchers found"
-
Of
bugs and brains: Gut bacteria affect multiple sclerosis - Science Daily,
7/20/10 - "This study shows for the first time that
specific intestinal bacteria have a significant role in affecting the
nervous system during MS -- and they do so from the gut, an anatomical
location very, very far from the brain ... Perhaps treatments for diseases
such as multiple sclerosis may someday include probiotic bacteria that can
restore normal immune function in the gut… and the brain"
-
Probiotics in pregnancy could have diabetes benefits: Study - Nutra USA,
7/16/10 - "those women who had taken probiotics had
a reduced frequency of gestational diabetes mellitus (GDM): 13 percent for
the diet/probiotics group, compared to 36 percent for the diet/placebo group
and 34 percent for the control group ... In addition, the dietary counseling
during pregnancy reduced the risk of fetal overgrowth, which is thought to
predispose to later obesity" - [Abstract]
-
Gut
bacteria could be key indicator of colon cancer risk -
"a shift in the balance between the "good" bacteria
and the "bad" bacteria that populate our gut could be a harbinger of colon
cancer ... We think something happens to tip the balance away from the
beneficial bacteria and in favor of microbes that make toxic metabolites and
are detrimental to our health ... By pinpointing these bacterial culprits,
we can not only identify people at risk, but also suggest that they include
the good bacteria in their diet .. And what a great way to address colon
cancer -- you could know your risk and lower it by eating your yogurt every
day" - Note: Dannon claims that only their Activia brand reaches the
gut. see:
-
Activia by Dannon
- "Specialists at Dannon® selected Bifidus
Regularis™ for Activia® because it survives passage through the
digestive tract, arriving in the colon as a living culture. Once there,
it plays a beneficial role in your intestinal ecosystem"
-
Oral
bacteria may offer probiotic potential against upper respiratory infections
- Science Daily, 6/18/10 - "So far, the benefits of
probiotics have been predominantly explored in the intestinal tract,
however, other initial studies suggest probiotics may contribute to wellness
in the stomach, vaginal tract, skin and mouth ... A probiotic strategy
effective in the prophylaxis of pharyngitis, therefore, could provide a
significant social benefit"
-
Probiotic therapy cuts risk of ventilator-associated pneumonia in half for
some in ICU, study finds - Science Daily, 6/17/10 -
"daily use of probiotics not only decreased VAP
infections by about 50 percent compared to placebo, but also reduced the
amount of antibiotics needed in comparison to placebo-treated patients. This
reduction in antibiotic consumption led to significantly fewer Clostridium
difficile infections in patients given probiotics. No side effects
attributable to the probiotics were observed"
-
Probiotic Reduces Crying Time in Infants With Colic - Medscape, 6/17/10
-
"One week of supplementation with the probiotic
Lactobacillus reuteri Protectis reduced crying time in colicky babies by
74%, compared with 38% with placebo" - See lactobacillus at Amazon.com.
-
Gut-residing bacteria trigger arthritis in genetically susceptible
individuals - Science Daily, 6/17/10 - "A single
species of bacteria that lives in the gut is able to trigger a cascade of
immune responses that can ultimately result in the development of arthritis
... In the absence of all bacteria, these mice didn't develop arthritis, but
the introduction of a single bacterium was enough to jump-start the immune
process that leads to development of the disease ... bacteria in the gut
could influence the development of an autoimmune disease affecting tissues
distant from the gut. Diseases such as irritable bowel syndrome have been
linked to gut-residing bacteria" - See
Garden of Life Primal Defense HSO Probiotic Formula at Amazon.com.
Also see my section in last week's
newsletter on making you own Activa.
-
15 best age-erasing superfoods - MSNBC, 5/25/10 -
"Yogurt ... Various cultures claim yogurt as their
own creation, but the 2,000-year-old food’s health benefits are not
disputed: Fermentation spawns hundreds of millions of probiotic organisms
that serve as reinforcements to the battalions of beneficial bacteria in
your body, which keep your digestive tract healthy and your immune system in
top form, and provide protection against cancer. Not all yogurts are
probiotic, though, so make sure the label says “live and active cultures.”"
-
Probiotics may help fat and weight loss: Study - Nutra USA, 6/11/10 -
"Twelve weeks of consuming a fermented milk product
containing the Lactobacillus strain was associated with a 4.6 per cent
reduction in abdominal fat, and a 3.3 per cent reduction in subcutaneous
fat" - [Abstract]
- See
Yogourmet Electric Yogurt Maker - I've had a lot of yogurt makers
over the years but this is the best one I've found. I mix two cups of
Nestle Nido Instant Dry Whole Milk (available at Amazon) with two
cups of dry skim milk in a blender. Lately I've been making it with
Activa. I believe it's only sold flavored but I've been using the
strawberry flavored Activa. I put the milk powders in a blender then
fill it with water and blend. Then add one container of the Activa and
blend fast one more time (not to kill the culture). Then pour it into
the jar and fill the jar to the top with additional water and leave it
in the yoghurt maker for 13 hours. I mix the finished product with
Smucker's Strawberry Orchard's Finest. If your worried about the
BPA's from the plastic container, see
Widemouth Clear Half Gallon Glass Jar (64oz) w/ White Metal Lid at
specialtybottles.com.
- Activia by Dannon
- "Specialists at Dannon® selected Bifidus
Regularis™ for Activia® because it survives passage through the
digestive tract, arriving in the colon as a living culture. Once there,
it plays a beneficial role in your intestinal ecosystem"
-
Yogurt-like drink DanActive reduced rate of common infections in daycare
children - Science Daily, 5/19/10 - "Researchers
found a 19 percent decrease of common infections among the children who
drank the yogurt-like drink with L. casei DN-114 001 compared to those whose
drink did not have the probiotic. More specifically, those who drank
DanActive had 24 percent fewer gastrointestinal infections (such as
diarrhea, nausea, and vomiting), and 18 percent fewer upper respiratory
tract infections (such as ear infections, sinusitis and strep). However, the
reduction in infections did not result in fewer missed school days or
activities -- also a primary outcome of the study" - [Abstract]
- Note: For what it's worth, I tried Activa in my
yogurt maker and it worked fine
however Activa has fruit mixed with it but most of it flouted to the top and
I was able to skim it off.
-
Probiotics for mum during pregnancy may cut obesity in child: Study -
Nutra USA, 2/16/10
-
Prebiotic-soy combination may boost heart health: Study - Nutra USA,
2/11/10
-
'Good' bacteria keep immune system primed to fight future infections -
Science Daily, 1/27/10 - "The investigators show
that "good" bacteria in the gut keep the immune system primed to more
effectively fight infection from invading pathogenic bacteria. Altering the
intricate dynamic between resident and foreign bacteria -- via antibiotics,
for example -- compromises an animal's immune response, specifically, the
function of white blood cells called neutrophils"
-
Promising probiotic treatment for inflammatory bowel disease - Science
Daily, 1/21/10 - "Several recent studies have
identified butyric acid as a potential therapeutic agent for IBD. Some gut
bacteria produce butyric acid naturally in the intestines, but in IBD
patients some of these strains are heavily depleted. Trials in mice have
shown that injecting one such strain Faecalibacterium prausnitzii into the
digestive tract is effective at restoring normal levels of gut bacteria and
treating the symptoms of IBD. In addition, novel identified
butyrate-producing strains, such as Butyricicoccus pullicaecorum, have been
shown to exert similar effects"
-
Another Cause of Obesity: The Bacteria in Your Gut? - Time Magazine,
11/12/09 - "When one group of mice was fed a typical
Western diet, high in fat and sugars, they tended to gain weight and grow
more Firmicutes gut bacteria and fewer Bacteroidetes. In mice given a
low-fat, plant-based chow, the distribution of the two groups of bugs
flipped and the animals remained lean. It's not clear whether the balance of
gut bugs causes weight gain or is a result of it, but the findings suggest
that a "gut profile" could potentially serve as a diagnostic tool for
identifying who might have a propensity for obesity. If, for instance, your
gut environment contains a preponderance of Firmicutes, then your body may
be predisposed to digest calories in a way that leads to greater fat
storage. In fact, in Gordon's earlier work with identical twins of different
weights, he found that the obese twin tended to have more Firmicutes
colonies than the leaner sibling ...factors like gut microbes, which
scientists traditionally would not think of exerting influence on genes, may
have a surprisingly powerful effect, changing how a body's genes would
normally control the way it digest food and breaks it down into energy"
-
Gut microflora and obesity: Study highlights potential for pre-,
probiotics - Nutra USA, 11/12/09 - "One
approach could involve searching for nutritional interventions to modify
specific gut microbial species. Dietary components (prebiotics) might be
found that alter growth of specific microbial species capable of
affecting host physiology, and the Turnbaugh model can be used to
pinpoint these elements and decipher the mechanisms of the host-microbe
collaboration"
-
Probiotics May Help Treat IBD Symptoms - WebMD, 10/29/09 -
"A new study shows treatment with the probiotic
Bacillus polyfermenticus reduced rectal bleeding, lessened tissue
inflammation, and promoted weight gain in mice with colitis. The mice also
had increased blood vessel growth in their intestinal lining, which is
important for healing damaged tissue. The probiotic also encouraged the
growth process of new blood vessels in laboratory tests with human
intestinal cells"
-
Diet
And Intestinal Bacteria Linked To Healthier Immune Systems - Science
Daily, 10/28/09 - "Insoluble dietary fibre, or
roughage, not only keeps you regular, say Australian scientists, it also
plays a vital role in the immune system, keeping certain diseases at bay ...
Similarly, probiotics and prebiotics, food supplements that affect the
balance of gut bacteria, reduce the symptoms of asthma and rheumatoid
arthritis, also inflammatory diseases"
-
Probiotics may protect against gum disease: Yakult study - Nutra USA,
9/30/09 - "One group was required to drink 65 ml of
Yakult daily, giving a daily probiotic dose of 100 billion bacteria per 100
ml. The other group was given no product to consume at all ... analysis of
the fluid between the gum and the tooth (gingival crevicular fluid) showed
that the probiotic was associated with reductions were in elastase activity,
and enzyme linked to inflammation, and matrix metalloproteinase-3 (MMP-3),
an enzyme that is responsible for the degradation of extracellular matrix
components and known to have increased activity during inflammation"
- [Abstract]
-
Prebiotics may stop early stage colon cancer: Study - Nutra USA, 9/4/09
-
Could probiotics protect us from gut parasites? - Nutra USA, 8/20/09
-
Probiotics may reduce cold and 'flu symptoms for children - Nutra USA,
7/30/09 - "A daily supplement of Lactobacillus and
Bifidobacterium strains may reduce the incidence of cold and 'flu-like
symptoms in children by 50 per cent ... A combination of the two strains was
linked to reductions in fever incidence by 73 per cent, a reduction in the
occurrence of runny noses by 59 per cent, and drop in the incidence of
coughing by 62 per cent" - [Abstract]
-
Antibiotics Take Toll On Beneficial Microbes In Gut - Science Daily,
6/18/09 - "Normally, a set of thousands of different
kinds of microbes lives in the gut – a distinctive mix for each person, and
thought to be passed on from mother to baby. The microbes, including many
different bacteria, aid digestion and nutrition, appear to help maintain a
healthy immune system, and keep order when harmful microbes invade ... Mice,
which normally develop a diverse set of microbes after being born without
one, then were given either cefoperazone, a broad-spectrum cephalosporin
antibiotic, or a combination of three antibiotics (amoxicillin, bismuth and
metronidazole) ... Both antibiotic treatments caused significant changes in
the gut microbial community. However, in the mice given cefoperazone, there
was no recovery of normal diversity. In other mice given the
amoxicillin-containing combination, the microbiota largely recovered, but
not completely ... Probiotics may be part of the solution, but we don’t know
that yet"
-
Probiotics may reduce eczema risk by 60 per cent - Nutra USA, 5/15/09 -
"The Dutch researchers report that parental-reported
eczema was 58 per cent lower in the intervention group compared with placebo
during the first three months of life, after which the incidence of eczema
was similar between the groups" - [Abstract]
-
Study In Pregnant Women Suggests Probiotics May Help Ward Off Obesity -
Science Daily, 5/7/09 - "One year after giving
birth, women were less likely to have the most dangerous kind of obesity if
they had been given probiotics from the first trimester of pregnancy, found
new research that suggests manipulating the balance of bacteria in the gut
may help fight obesity ... Central obesity, where overall obesity is
combined with a particularly fat belly, is considered especially unhealthy
... We found it in 25% of the women who had received the probiotics along
with dietary counselling, compared with 43% in the women who received diet
advice alone"
-
How
Probiotics Can Prevent Disease - Science Daily, 4/1/09 -
"In each instance the protection was linked to a
particular bacterial species, and the mechanism of action varied from direct
antagonism (where the probiotic directly kills the pathogenic bacteria) to
effects mediated by the host immune system. For example Lactobacillus
salivarius UCC118 protected mice against listeriosis (a disease which can
affect pregnant women) by producing an antimicrobial peptide that eliminates
Listeria monocytogenes in the gut of the animal. In another mechanism,
Lactococcus lactis could be used to treat mastitis by eliciting an immune
response that overwhelmed the infectious bacterium"
-
Probiotics May Relieve Symptoms of Irritable Bowel Syndrome - Medscape,
3/20/09 - "In patients with IBS, probiotics showed a
modest improvement in overall symptoms, using both dichotomous and
continuous data"
-
New Yogurt Fights Stomach Ulcers - WebMD, 3/22/09 -
"H. pylori uses an enzyme called urease to attach to
and infect the inside of the stomach. This latest yogurt, designed to fight
stomach ulcers, contains an antibody called
IgY-urease. The yogurt is marketed as Dr. Piro in Japan and as Gut in Korea.
Researchers are hopeful that their clinical trial will pave the way for
approval in the United States ... For the trial, scientists recruited 42
people who tested positive for H. pylori. Some participants ate the yogurt
with the antibody three times a day for four weeks. Some participants ate
the same amount of regular yogurt that didn't contain the antibody. H.
pylori activity was significantly reduced in the antibody yogurt group"
-
Supplement Of Probiotics Provides A New Therapy For Ulcerative Colitis -
Science Daily, 2/27/09
-
Probiotics May Help People Taking Antibiotics - Science Daily, 12/17/08
-
"Up to one in five people on antibiotics stop taking
their full course of antibiotic therapy due to diarrhea. Physicians could
help patients avoid this problem by prescribing probiotics"
-
Yoghurt can benefit bladder cancer, say researchers - Nutra USA,
10/21/08 - "yoghurt consumption reduced the risk of
cancer in men by 36 per cent and in women by 45 per cent. Other dairy
products did not reveal such benefits and the researchers suggested this was
down to the inherent functionality present in many yoghurts and not just
those with boosted probiotic levels ... Cultured milk products, such as
yoghurt, contain lactic acid bacteria, which have been shown to suppress
bladder cancer in rats" - [Abstract]
- See
Yogourmet Electric Yogurt Maker and
Nestle Nido Instant Milk Powder Mexico 1600g (3.5 Pounds) - Case of 6.
I mix the Nido full fat and Carnation non-fat (50/50).
-
Probiotic May Help Treat Crohn's Disease - WebMD, 10/20/08 -
"A gut bacterium called F. prausnitzii may make a
good probiotic treatment for Crohn's disease"
-
Cultured
milk, yogurt, and dairy intake in relation to bladder cancer risk in a
prospective study of Swedish women and men - Am J Clin Nutr. 2008
Oct;88(4):1083-7 - "Total dairy intake was not
significantly associated with risk of bladder cancer [> or =7.0 servings/d
compared with < 3.5 servings/d: multivariate rate ratio (RR) = 0.87; 95% CI:
0.66, 1.15; P for trend = 0.33]. However, a statistically significant
inverse association was observed for the intake of cultured milk (sour milk
and yogurt). The multivariate RRs for the highest category of cultured milk
intake (> or =2 servings/d) compared with the lowest category (0 serving/d)
were 0.62 (95% CI: 0.46, 0.85; P for trend = 0.006) in women and men
combined, 0.55 (95% CI: 0.25, 1.22; P for trend = 0.06) in women, and 0.64
(95% CI: 0.46, 0.89; P for trend = 0.03) in men. The intake of milk or
cheese was not associated with bladder cancer risk ... These findings
suggest that a high intake of cultured milk may lower the risk of developing
bladder cancer"
-
'Friendly' Bacteria Protect Against Type 1 Diabetes, Researchers Find -
Science Daily, 9/21/08 - "mice exposed to common
stomach bacteria were protected against the development of Type I diabetes
... if they were raised in a germ-free environment, lacking "friendly'' gut
bacteria, the mice developed severe diabetes. NOD mice exposed to harmless
bacteria normally found in the human intestine were significantly less
likely to develop diabetes"
-
Does
Probiotic Intervention Induce The Serum Global Lipid Profile Change? -
Science Daily, 9/18/08 - "investigated the effect of
a three weeks intervention of a probiotic LGG intervention on serum global
lipidomics profiles in healthy adults. The result showed that there were
decreases in the levels of lysophosphatidylcholines (LysoGPCho),
sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), and
increases in triacylglycerols (TAG) in the probiotic LGG group. These
changes may contribute, for example, to the metabolic events behind the
beneficial effects of LGG on gut barrier function seen in previous studies"
-
Is
Probiotic Yakult Helpful In The Treatment Of Irritable Bowel Syndrome? -
Science Daily, 9/10/08 - "A pilot study was
undertaken to determine the effect of L. strain Shirota (Yakult®) on
intestinal fermentation patterns of IBS patients. After 6 week of treatment
with 1 x 65 mL dose of Yakult(R) daily, 9 of 14 patients (64%) completing
the study had reversal of ERBHAL, with the median time of first rise
increasing from 45 to 75 min (P = 0.03). Furthermore, symptoms improved in
those in whom ERBHAL was corrected"
-
How
Friendly Bacteria Avoids Immune Attack To Live Happily In The Gut -
Science Daily, 9/2/08
-
'Good' Bacteria May Ease Hay Fever - WebMD, 6/4/08
-
Hayfever Hope: Probiotic Drink Can Modify Immune System's Response To Grass
Pollen - Science Daily, 6/4/08 - "contained
Lactobacillus casei ... The probiotic strain we tested changed the way the
body's immune cells respond to grass pollen, restoring a more balanced
immune response"
-
Probiotics may offer hay fever hope - Nutra USA, 6/3/08 -
"Hayfever is an allergic reaction to pollen or
fungal spores, most commonly grass pollen. The immune system mistakes the
spores for harmful invaders and white blood cells - T-helper type 2 (Th2)
lymphocytes - produce protein-like cytokines, such as interleukin-4 (IL-4),
IL-5 and IL-6, which in turn promote the synthesis of the immune chemicals
immunoglobulins (Ig) to bind to the pollen and fight them off ... However,
supplementation with the probiotic led to reduced production of IL-5 and
IL-6, as well as decreased in the production of IgE ... The
probiotic-supplemented volunteers had significantly reduced levels of IL-5
and IL-6" - [Abstract]
-
What
Else May Probiotics Do In Adults? - Science Daily, 5/20/08 -
"It was found that probiotics have an
anti-inflammatory potential seen as a decrease in serum CRP levels and as a
reduction in bacteria-induced production of proinflammatory cytokines in
peripheral blood mononuclear cells"
-
Probiotic hope for
kidney stones - BBC News, 3/9/08 - "People
naturally carrying the bacterium Oxalobacter formigenes were found to be 70%
less likely to have problems"
-
Probiotic Cuts Respiratory Illness Rates In Endurance Athletes, Study
Suggests - Science Daily, 2/18/08 - "The
probiotic Lactobacillus substantially cuts the rate and length of
respiratory illness in professional long distance runners ... athletes
taking the probiotic had less than half the number of days of symptoms of
their colleagues taking the placebo ... Respiratory symptoms while taking
Lactobacillus lasted 30 days compared with 72 days while taking the placebo"
- [Nutra
USA] - See my favorite
Garden of Life Primal Defense HSO Probiotic Formula at Amazon.com.
-
Probiotics 'protect
top athletes' - BBC News, 2/14/08 - "Over the
four months, all 20 received two month-long courses of pills - one
containing the bacterium Lactobacillus fermentum, and the other containing
no active ingredients ... a total of 72 days in which people taking the
"dummy" pills complained of symptoms ... When the same number of "probiotic"
days was examined, only 30 were hit by illness"
-
Infants With Poor Intestinal Flora Often Develop Eczema - Science Daily,
1/23/08 - "children with only a limited variety of
bacteria in their feces one week after birth more often developed atopical
eczema by the age of 18 months"
-
Probiotics 'have
effects on gut' - BBC News, 1/16/08 - "Our study
shows that probiotics can have an effect and they interact with the local
ecology and talk to other bacteria"
-
Clinical trial: multispecies probiotic supplementation alleviates the
symptoms of IBS and stabilises intestinal microbiota - Aliment Pharmacol
Ther. 2007 Oct 6 - "The composite IBS score had at
five months decreased 14 points (95% CI: -19 to -9) from baseline with the
multispecies probiotic versus 3 points (95% CI: -8 to 1) with placebo
(p=0.0083). Especially distension and abdominal pain were affected"
-
Appendix Isn't Useless At All: It's A Safe House For Good Bacteria -
Science Daily, 10/8/07
-
Probiotics work out against constipation, says study - Nutra USA,
8/10/07 - "the frequency of bowel movements doubled
over the weeks following the start of probiotic supplementation, increasing
from two per week to 4.2 after two weeks, to 3.8 after four weeks" [Abstract]
-
Probiotic
Supplements (Including Lactobacillus acidophilus, Bifidobacterium, and
Others) review - ConsumerLab.com, 12/13/06
-
Elderly 'should take probiotics' - BBC News, 8/7/06 -
"the drinks, yoghurts or capsules could help protect
older people against bowel conditions, such as Irritable Bowel Syndrome
(IBS) ... as people get older they have reduced levels of friendly bacteria
and increased levels of disease-causing bacteria ... at about the age of 60
there was a big drop in bacteria levels, and older people had 1,000-fold
less friendly bacteria than other younger adults"
-
Probiotics May Help Stressed Gut - WebMD, 4/25/06 -
"Harmful bacteria latched onto cells in the
intestinal wall and nearby lymph nodes of stressed rats with sterile
drinking water ... Stressed rats that had gotten probiotics in their
drinking water showed no signs of harmful bacteria leaking to their lymph
nodes"
-
Probiotic Yogurt May Help Eradicate H. pylori Infection - Medscape,
4/17/06 - "Four weeks of pretreatment with AB-yogurt
before quadruple therapy improves eradication rate of residual H. pylori
after failed triple therapy"
-
'Good' Bacteria: Good for Colds? - WebMD, 11/7/05
-
Workers On Daily Probiotics Less Likely To Take Time Off Sick - Science
Daily, 11/7/05 - "workers who took a daily dose of
the probiotic bacteria Lactobacillus reuteri were 2.5 times less likely to
take sick leave than workers who took a placebo"
-
SA, 3/31/05
- A Healthy Gut May
Resist Allergies, Asthma - WebMD, 12/23/04 -
"People need a mix of healthy bacteria and fungi in their guts. Microflora
in humans can be thrown off by antibiotics and a sugary, high-fat, low-fiber
diet"
-
Good Bacteria Trigger Proteins To Protect The Gut
- Science Daily, 7/23/04 - "the practice of giving
antibiotics to cancer patients to prevent infections might render the gut
more vulnerable to damage – a danger that might be overcome by administering
substances that mimic the protective presence of gut bacteria"
-
Probiotics, dead or alive, can relieve gut disease
- Nutra USA, 2/2/04
-
Probiotic Therapy May Be Effective for Treating Ulcerative Colitis
- Doctor's Guide, 5/21/03 - "adding a probiotic with
multiple strains and a high concentration of bacteria to the treatment
regimen may have the potential to stop
this disease in its tracks and avoid any treatment-related side effects"
- Quality of Probiotic
Supplements Questioned: Are You Getting What You Pay For?
- New Hope Natural Media, 1/16/02 - "laboratory
testing of 12 refrigerated and 8 non-refrigerated, randomly selected
probiotic supplements obtained from different health food stores revealed
that only one product contained the same bacteria as those listed on the
label. Many of the refrigerated products had some beneficial bacteria, but
contained fewer species of organisms than the label claimed. More than 30%
of all supplements were contaminated with other microorganisms and 50% of
the non-refrigerated products were completely dead. Dead probiotics have no
impact on improving intestinal function or restoring the balance of normal
intestinal flora"
- Lactobacillus
Preparation Prevents Complications in Acute Pancreatitis
- New Hope Natural Media, 1/2/03
- Eating Yogurt Daily
Increases “Good” Cholesterol in Women
- New Hope Natural Media, 12/5/02 - "In this study,
29 women ate 300 grams (about 10.6 ounces) of a full-fat (3.5% fat by
weight) yogurt product daily for 21 weeks ... A larger, and statistically
significant, 38% increase was observed in
HDL, or “good” cholesterol levels after eating the yogurt. No change was
observed in LDL, or “bad,” cholesterol levels ... each woman also ate the
probiotic- and prebiotic-containing product for a 7-week stretch during the
21-week trial. During the period when the women consumed the supplemented
yogurt, there was a further increase in HDL cholesterol beyond that seen
from simply eating plain yogurt"
-
Probiotics—Good Bacteria Meet Functional Foods - Functional Foods &
Nutraceuticals, 11/02
-
“Friendly Bacteria” Help Eradicate the Peptic-Ulcer Organism - New Hope
Natural Media, 10/17/02 - "Taking a supplement of
“friendly bacteria” (probiotics) increases the
effectiveness of conventional antibiotic therapy in eradicating Helicobacter
pylori (H. pylori), the organism that causes peptic ulcers"
-
New Research Validates Use Of Once-Daily High Dose "Good" Bacteria In
Patients With Recurrent Or Refractory Pouchitis - Doctor's Guide,
5/24/02 -
"We are excited about the results of this study
because a specific amount and type of probiotic has demonstrated that it can
dramatically improve patient outcome for pouchitis," said lead investigator,
Dr. Mimura. "Furthermore, because pouchitis may be considered a model for
other inflammatory bowel diseases (IBD), these
findings indicate we may have found an effective, inexpensive, and widely
available therapeutic treatment for various forms of IBD, such as ulcerative
colitis."
-
Headaches-Germ Link Suggested - Intelihealth, 4/29/02 -
"about 18 percent of chronic migraine
sufferers were infected with the stomach bug
helicobacter pylori and antibiotics
appeared to clear the headaches ... Adding the friendly bacteria
Lactobacillus seemed to work even better ... Helicobacter pylori, the bug
that causes gut ulcers, has recently been linked to a growing list of
diseases, including heart disease, autoimmune diseases and skin conditions"
-
Lactobacillus Safe, Effective For Infectious Diarrhoea In Children
- Doctor's Guide, 4/8/02
-
Probiotics During Pregnancy, Lactation May Promote Immunoprotection Against
Atopic Eczema - Doctor's Guide, 2/8/02 -
"Probiotics administered during pregnancy and lactation appears to promote
the immunoprotective potential of breast-feeding ... The probiotics also
protect infants against atopic eczema during the first two years"
-
Feeling Fit: Good bacteria - CNN, 2/5/02
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the
rich and famous, Oz Garcia is singing the praises of the Life Extension
Foundation and its products in his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene,
gamma tocopherol, vinpocetine, SAMe,
folic acid, carnosine,
glutathione, DMAE, Huperzine A, probiotics,
MSM,
secretagogues,
arginine pyroglutamate, IP-6,
bioflavonoid formulas and
grape skin/seed extracts"
-
Probiotic LP299V Could Help Patients With Irritable Bowel
- Doctor's Guide, 10/31/01 - "The probiotic
Lactobacillus plantarum 299V (LP299V) appears to have a beneficial effect on
patients with
irritable bowel syndrome (IBS) ... All patients treated with LP299V
reported resolution of their abdominal pain as compared to 11 patients from
the placebo group"
-
Can lactobacillus prevent viral infections? - Nutrition Science News,
9/01 - "Probiotic supplement use was associated with
a significantly reduced risk of diarrhea; only three children (6.7 percent)
in the group given probiotics had diarrhea, yet 12 children (33.3 percent)
in the placebo group experienced diarrhea"
-
Going With the Gut May Prevent Allergy, Asthma, Good Bacteria May Help a
Child's Immune System - WebMD, 4/5/01 - "kids
who were given the probiotics were only half as likely to have common
allergic diseases as those who received the placebo"
-
Study Suggests Probiotics Could Reduce Childhood Eczema - Intelihealth,
4/5/01 - "Supplements of friendly bacteria could
halve the chances of infants developing eczema, an incurable skin disease
some babies never outgrow, scientists have found"
- Missing Intestinal
Bacterium Linked To Kidney Stones In CF Patients - Doctor's Guide,
9/25/98 - "The study is one of the first to directly
link an absence of the organism, known as Oxalobacter formigenes, to the
formation of the painful crystals ... O. formigenes appears to break down
calcium oxalate before it can form crystals that evolve into kidney stones
... Peck and colleagues suspect prolonged antibiotic use and other high-dose
drug regimens may preclude natural colonisation with the organism, or may
irreversibly destroy the colonies"
Abstracts:
-
Probiotics, prebiotics, and
synbiotics in type 1 diabetes mellitus: A systematic review and meta-analysis of
clinical trials - Diabetes Metab Res Rev 2023 May 14 -
"Dysbiosis or imbalance of microbes in the gut has been
associated with susceptibility and progression of type 1 diabetes mellitus
(T1DM). The present systematic review and meta-analysis examined the effects of
probiotics, prebiotics, and synbiotics on fasting blood glucose (FBG),
haemoglobin A1c (HbA1c), C-peptide, and insulin requirements in T1DM patients
... The pooled effect size showed that FBG decreased following probiotic
supplementation (weighted mean difference = -31.24 mg/dL; 95% confidence
interval = -45.65, -16.83; p < 0.001), however, there was no significant
improvement in serum HbA1c, C-peptide, and insulin requirements. Probiotic
supplementation could be a complementary therapeutic strategy in T1DM. The
evidence is limited; therefore, it is crucial to conduct more trials" -
See probiotic supplements at Amazon.com.
-
The potential beneficial
effects of Lactobacillus plantarum GM11 on rats with chronic unpredictable mild
stress- induced depression - Nutr Neurosci 2023 Apr 28 -
"This work has revealed that LacP GM11 has potential
beneficial effects on depression. This effect might be related to alleviating
monoamine neurotransmitter deficiency, HPA axis hyperfunction and CREB-BDNF
signaling pathway downregulation. This study demonstrates that LacP GM11 could
be a potential therapeutic approach to treat depression and other mental health
problems" - See Lactobacillus plantarum
at Amazon.com.
-
The effects of live and
pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut
microbiota, and metabolomics in mice - Food Funct 2023 Apr 26 -
"Notably, prophylactic supplementation of pasteurized A.
muciniphila increased the relative abundance of the anti-inflammatory microbe
Dubosiella, thereby activating intestinal sphingolipid metabolism to alleviate
intestinal damage. In conclusion, pasteurized A. muciniphila showed a more
effective amelioration of DSS-induced colitis by repairing the dysbiosis of gut
microbiota and intestinal metabolism compared to live A. muciniphila, providing
a potential strategy to explore the protective effect of A. muciniphila on host
intestinal health" - See Akkermansia
muciniphila at Amazon.com.
-
Oral Administration of Mixed
Probiotics Improves Photoaging by Modulating the Cecal Microbiome and MAPK
Pathway in UVB-Irradiated Hairless Mice - Mol Nutr Food Res 2023 Apr 20 -
"Continuous ultraviolet (UV) exposure causes skin
photoaging, wrinkle formation, and skin barrier damage. In this study, the
protective effect of mixed probiotics (MP) against photoaging in UVB-irradiated
Hs68 fibroblasts and SKH-1 hairless mice was investigated ... Collectively,
these findings suggest that MP modulates the gut microbiome and ameliorates
UVB-induced photoaging by downregulating the MAPK pathway"
-
The Polyunsaturated Fatty
Acids Eicosapentaenoic Acid and Docosahexaenoic Acid, and Vitamin K1 Modulate
the Gut Microbiome: A Study Using an In Vitro Shime Model - J Diet Suppl
2023 Apr 20;1-19 - "Omega-3 polyunsaturated fatty acids
(PUFAs) and vitamins exert multiple beneficial effects on host health, some of
which may be mediated through the gut microbiome. We investigated the prebiotic
potential of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and
lipid-soluble phylloquinone (vitamin K1), each at 0.2x, 1x and 5x using the
simulator of the human intestinal microbial ecosystem (SHIME®) to exclude in
vivo systemic effects and host-microbe interaction ... In conclusion, our in
vitro data further establish a role of PUFAs and vitamin K to modulate the gut
microbiome with effects on the production of SCFAs and barrier integrity"
- See omega-3 supplements at Amazon.com
and vitamin K at Amazon.com.
-
Prebiotics alleviate
cartilage degradation and inflammation in post-traumatic osteoarthritic mice by
modulating the gut barrier and fecal metabolomics - Food Funct 2023 Apr 20 -
"Osteoarthritis (OA) is a degenerative joint disease
characterized by articular cartilage degeneration, subchondral bone sclerosis,
synovial hyperplasia and inflammation as the main pathological manifestations.
This study aims to investigate the protective effect of prebiotics in
post-traumatic osteoarthritic (PTOA) mice by modulating the gut barrier and
fecal metabolomics. The results suggested that cartilage degeneration,
osteophyte formation and inflammation were significantly reduced by prebiotics
in PTOA mice. In addition, the gut barrier was protected by the increased
expression of tight junction proteins ZO-1 and occludin in the colon.
High-throughput sequencing found that 220 fecal metabolites were affected by
joint trauma, 81 of which were significantly recovered after probiotic
intervention, and some metabolites (valerylcarnitine, adrenic acid, oxoglutaric
acid, etc.) were closely associated with PTOA. Our study demonstrates that
prebiotics can delay the progression of PTOA by regulating the metabolites of
the gut microbiota and protecting the gut barrier, which is expected to be an
intervention method for PTOA"
-
Synbiotics as Supplemental
Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with
Solid Tumours - Nutrients 2023 Apr 4 - "One of the
approaches to reduce or avoid chemotherapy-associated complications is to
restore the gut microbiota. Gut microbiota is essential for the healthy
functioning of the immune system, metabolism, and the regulation of other
molecular responses in the body. Chemotherapy erodes the mucosal layer of the
gastrointestinal tract and results in the loss of gut microbiota. One of the
ways to restore the gut microbiota is through the use of probiotics. Probiotics
are the 'good' bacteria that may provide health benefits if consumed in
appropriate amounts. Some studies have highlighted that the consumption of
probiotics in combination with prebiotics, known as synbiotics, may provide
better health benefits when compared to probiotics alone" - See
synbiotic supplements at Amazon.com.
-
Meta-analysis of randomized controlled trials of the effects of
probiotics in Parkinson's disease - Food Funct 2023 Mar 28 -
"Oral probiotic consumption
significantly improved motor symptoms, gastrointestinal
dysfunction, anxiety, and depression in patients with PD.
Notably, oral probiotics also reduced the use of laxatives and
increased GSH levels in the serum of patients with PD" -
See probiotic supplements at Amazon.com.
-
Bifidobacterium longum supplementation improves age-related
delays in fracture repair - Aging Cell 2023 Jan 27 -
"Age-related delays in bone repair
remains an important clinical issue that can prolong pain and
suffering. It is now well established that inflammation
increases with aging and that this exacerbated inflammatory
response can influence skeletal regeneration. Recently, simple
dietary supplementation with beneficial probiotic bacteria has
been shown to influence fracture repair in young mice ... We
found that B. longum supplementation accelerated bony callus
formation which improved mechanical properties of the fractured
limb. We attribute these pro-regenerative effects of B. longum
to preservation of intestinal barrier, dampened systemic
inflammation, and maintenance of the microbiota community
structure. Moreover, B. longum attenuated many of the
fracture-induced systemic pathologies. Our study provides
evidence that targeting the gut microbiota using simple dietary
approaches can improve fracture healing outcomes and minimize
systemic pathologies in the context of aging." - See
probiotic supplements at Amazon.com.
-
Probiotic
supplements are effective in people with cognitive impairment: a
meta-analysis of randomized controlled trials - Nutr Rev
2023 Jan 11 - "Cognitive function is a
significant concern among the elderly and has a major negative
effect on their quality of life. Probiotics have a positive
effect on improving cognition, but the exact nature of the
association between probiotic supplements and cognitive function
is poorly understood ... According to this meta-analysis,
probiotic supplementation had a highly significant effect on
cognitive function in people with cognitive impairment or
Alzheimer's disease. For people without cognitive impairment,
probiotic supplementation may be ineffective"
-
Effects of
probiotics supplementation on blood pressure: An umbrella
meta-analysis of randomized controlled trials - Nutr Metab
Cardiovasc Dis 2022 Oct 12 - "The
present umbrella meta-analysis suggests probiotics
supplementation to improve BP and claims that probiotics could
be used as a complementary therapy for controlling high BP"
-
Lacticaseibacillus casei ATCC334 Ameliorates Radiation-Induced
Intestinal Injury in Rats by Targeting Microbes and Metabolites
- Mol Nutr Food Res 2022 Nov 21 - "These
results highlight that medium and high doses of L. casei ATCC334 alleviate
radiation-induced intestinal damage by enhancing the mucosal barrier and
remodeling the gut microbiota structure and metabolic activity"
-
Impact of probiotics on
muscle mass, muscle strength and lean mass: a systematic review and
meta-analysis of randomized controlled trials - J Cachexia Sarcopenia Muscle
2022 Nov 22 - "Probiotics have shown potential to
counteract sarcopenia, although the extent to which they can influence domains
of sarcopenia such as muscle mass and strength in humans is unclear ...
Probiotic supplementation enhances both muscle mass and global muscle strength;
however, no beneficial effects were observed in total lean mass. Investigating
the physiological mechanisms underpinning different ageing groups and
elucidating appropriate probiotic strains for optimal gains in muscle mass and
strength are warranted"
-
Akkermansia muciniphila
ameliorates depressive disorders in a murine alcohol-LPS (mALPS) model -
Food Funct 2022 Nov 23 - "We found that acute alcohol
treatment damaged the intestinal barrier and caused dysbiosis, which further
increased the translocation of LPS and neuroinflammatory responses (TNF-α and
IL-1β) and led to abnormal expression of the depression-related genes, i.e. BDND
and IDO, reduced the levels of 5-HT and caused depressive behaviors in mice.
Probiotic intervention could improve depressive symptoms without notable adverse
effects. Akkermansia muciniphila (AKK), one of the next-generation probiotics,
has been widely used for the restoration of the intestinal barrier and reduction
of inflammation. Here, we found that AKK significantly ameliorated
alcohol-related depressive behaviors in a mALPS model, through enhancing the
intestinal barrier and maintaining the homeostasis of the gut microbiota.
Furthermore, AKK reduced serum LPS, ameliorated neuroinflammation (TNF-α and
IL-1β), normalized the expression of depression-related genes and increased the
5-HT levels in the hippocampus. Our study suggests that AKK supplements will be
a promising therapeutic regime for alcohol-associated depression in the future"
- See
Akkermansia muciniphila at Amazon.com.
-
Live and pasteurized
Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric
acid metabolism, inflammation, and gut microbiota - Food Funct 2022 Nov 14 -
"Akkermansia muciniphila (A. muciniphila) has been
demonstrated to exhibit beneficial effects against various metabolic diseases,
but whether A. muciniphila has an anti-hyperuricemia effect remains unexplored
... These findings suggest that both live or pasteurized A. muciniphila could
effectively attenuate hyperuricemia by moderating uric acid metabolism and
inflammation, and live bacteria exhibit additional beneficial effects on the gut
microbiota. These findings highlight that A. muciniphila could be potentially
developed as a probiotic or postbiotic to combat hyperuricemia" - See
Akkermansia muciniphila at Amazon.com.
-
Emerging Evidence on the Use
of Probiotics and Prebiotics to Improve the Gut Microbiota of Older Adults with
Frailty Syndrome: A Narrative Review - J Nutr Health Aging 2022 -
"The gut microbiota can impact older adults' health,
especially in patients with frailty syndrome. Understanding the association
between the gut microbiota and frailty syndrome will help to explain the
etiology of age-related diseases. Low-grade systemic inflammation is a factor
leading to geriatric disorders, which is known as "inflammaging". Intestinal
dysbiosis has a direct relationship with low-grade systemic inflammation because
when the natural gut barrier is altered by age or other factors, some
microorganisms or their metabolites can cross this barrier and reach the
systemic circulation ... The gut microbiota participates in many metabolic
processes that have an impact on the brain, muscles, and other organs. These
processes integrate feedback mechanisms, comprising their respective axis with
the intestine and the gut microbiota. Alterations in these associations can lead
to frailty. We report a few interventions that demonstrate that prebiotics and
probiotics could modulate the gut microbiota in humans" - See
prebiotic supplements at
Amazon.com and probiotic supplements at Amazon.com.
-
The effect of probiotics on
postsurgical complications in patients with colorectal cancer: a systematic
review and meta-analysis - Nutr Rev 2022 Sep 15 -
"Clinical trials have investigated the effect of probiotics on postsurgical
complications in colorectal cancer (CRC). However, so far, there are no
systematic reviews evaluating the effect of probiotics and synbiotics on the
clinical or infectious postsurgical complications of colorectal cancer ...
Probiotics and synbiotics seem to be a promising strategy for the prevention of
postoperative complications after CRC surgery"
-
Lactobacillus plantarum
HNU082 alleviates dextran sulfate sodium-induced ulcerative colitis in mice
through regulating gut microbiome - Food Funct 2022 Sep 16 -
"Probiotics have shown good efficacy in the prevention
of ulcerative colitis (UC), but the specific mechanism remains unclear ... In
conclusion, improving gut microbiota dysbiosis, protecting the intestinal
mucosal barrier, regulating inflammatory and disease pathways, and affecting
neutrophil infiltration are the potential mechanisms of probiotic Lp082 in
alleviating UC. Our study enriches the mechanism and provides a new prospect for
Lactobacillus plantarum HNU082 in the prevention of colitis, provides support
for the development of probiotic-based microbial products as an alternative
prevention strategy for UC, and provides guidance for the future probiotic
prevention of human colitis"
-
Probiotics Treatment Can
Improve Cognition in Patients with Mild Cognitive Impairment: A Systematic
Review - J Alzheimers Dis 2022 Sep 8 - "These
results support the intervention with probiotics, especially as a preventive
approach"
-
Probiotics supplementation
and brain-derived neurotrophic factor (BDNF): a systematic review and
meta-analysis of randomized controlled trials - Nutr Neurosci 2022 Aug 22 -
"Overall, meta-analysis of 11 trials (n = 648
participants) showed no significant changes in serum level of BDNF following
probiotics. However, subgroup analysis revealed that probiotics increased BDNF
levels in individuals suffering from neurological disorders (n = 214
participants; WMD = 3.08 ng/mL, 95% CI: 1.83, 4.34; P = 0.001; I2 = 7.5%;
P-heterogeneity 0.34), or depression (n = 268 participants; WMD = 0.77 ng/mL,
95% CI: 0.07, 1.47; P = 0.032; I2 = 88.4%; P-heterogeneity < 0.001).
Furthermore, a significant increase in BDNF levels was found in studies that
administered the mixture of Lactobacillus and Bifidobacterium genera, and were
conducted in Asia"
-
The safety and efficacy of
probiotic supplementation for critically ill adult patients: a systematic review
and meta-analysis - Nutr Rev 2022 Aug 19 -
"Probiotics, however, provided a significant reduction in ICU-acquired
infections (risk ratio .73"
-
Akkermansia muciniphila
Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal
Mucosal Barrier Disruption - Nutrients 2022 Jul 30 -
"Our work indicates that A. muciniphila ameliorates the disruption of the
intestinal mucosal barrier under high fructose and restraint stress. These
results provided a rationale for the development of probiotic colonization for
the prevention or treatment of intestinal diseases"
-
Effects of probiotic
supplementation on glucose metabolism in pregnant women without diabetes: a
systematic review and meta-analysis - Food Funct 2022 Jul 19 -
"Overall, probiotic supplementation significantly
reduced GDM incidence (Risk Ratio (RR) = 0.62 ... This meta-analysis suggested
that probiotic supplementation may lead to an improvement in glycemic control
and reduction of GDM incidence in pregnant women" - See
probiotic supplements at Amazon.com.
-
Bifidobacterium longum BL-10
with Antioxidant Capacity Ameliorates Lipopolysaccharide-Induced Acute Liver
Injury in Mice by the Nuclear Factor-κB Pathway - J Agric Food Chem 2022 Jul
7 - "Bifidobacterium longum is frequently utilized and
has broad prospects for preventing liver injury ... lipopolysaccharide
(LPS)-induced acute liver injury ... Overall, all the results demonstrated that
B. longum BL-10 had excellent efficiency in preventing LPS-induced ALI"
- See
probiotic supplements at Amazon.com.
-
Akkermansia muciniphila
prevents cold-related atrial fibrillation in rats by modulation of TMAO induced
cardiac pyroptosis - EBioMedicine 2022 Jul 4 - "Cold
exposure is one of the most important risk factors for atrial fibrillation (AF),
and closely related to the poor prognosis of AF patients ... Our findings
revealed a novel causal role of aberrant gut microbiota and metabolites in
pathogenesis of cold-related AF, which raises the possibility of selectively
targeting microbiota and microbial metabolites as a potential therapeutic
strategy for cold-related AF" - See
Akkermansia muciniphila at Amazon.com.
-
Lactobacillus acidophilus
LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch
and TLR4/NF-κB signal pathways and remodeling the gut microbiota - Food
Funct 2022 Jul 6 - "LA85 can be used as a dietary
supplement to potentially enhance the immune capacity of patients"
-
Manipulation of Gut
Microbiota as a Key Target for Crohn's Disease - Front Med (Lausanne) 2022
Jun 16 - "Other medications often used concomitantly in
IBD, such as antibiotics, antidepressants, oral contraceptives, opioids, and
proton pump inhibitors, have shown to alter the gut microbiota and account for
increased susceptibility to disease onset or worsening of disease progression.
In contrast, some environmental modifications through alternative therapies
including fecal microbiota transplant (FMT), diet and dietary supplements with
prebiotics, probiotics, and synbiotics have shown potential protective effects
by reversing microbiota dysbiosis or by directly promoting beneficial microbes,
together with minimal long-term adverse effects" - See
probiotic supplements at Amazon.com,
prebiotic supplements at
Amazon.com and synbiotic supplements at Amazon.com.
-
New Horizons in the
Treatment of Age-Associated Obesity, Sarcopenia and Osteoporosis - Drugs
Aging 2022 Jul 4 - "The rapid increase in both the
lifespan and proportion of older adults in developed countries is accompanied by
the dramatic growth of age-associated chronic diseases, including obesity,
sarcopenia, and osteoporosis. Hence, prevention and treatment of age-associated
chronic diseases has become increasingly urgent. The key to achieving this goal
is a better understanding of the mechanisms underlying their pathophysiology,
some aspects of which, despite extensive investigation, are still not fully
understood. Aging, obesity, sarcopenia, and osteoporosis are characterized by
the creation of a systemic, chronic, low-grade inflammation (SCLGI). The common
mechanisms that govern the development of these chronic conditions include a
failed resolution of inflammation. Physiologically, the process of inflammation
resolution is provided mainly by specialized pro-resolving mediators (SPMs)
acting via cognate G protein-coupled receptors (GPCRs). Noteworthy, SPM levels
and the expression of their receptors are significantly reduced in aging and the
associated chronic disorders. In preclinical studies, supplementation of SPMs or
their stable, small-molecule SPM mimetics and receptor agonists reveals clear
beneficial effects in inflammation-related obesity and sarcopenic and
osteoporotic conditions, suggesting a translational potential. Age-associated
chronic disorders are also characterized by gut dysbiosis and the accumulation
of senescent cells in the adipose tissue, skeletal muscle, and bones. Based on
these findings, we propose SCLGI resolution as a novel strategy for the
prevention/treatment of age-associated obesity, sarcopenia, and osteoporosis.
Our approach entails the enhancement of inflammation resolution by SPM mimetics
and receptor agonists in concert with probiotics/prebiotics and compounds that
eliminate senescent cells and their pro-inflammatory activity" - See
probiotic supplements at Amazon.com and
prebiotic supplements at
Amazon.com.
-
Lactobacillus reuteri J1
prevents obesity by altering the gut microbiota and regulating bile acid
metabolism in obese mice - Food Funct 2022 Jun 20 -
"Obesity is closely related to metabolic syndromes such as hyperlipidemia and
diabetes and has become a global public health problem. Probiotics are now used
as a treatment for obesity, but the mechanism by which probiotics treat obesity
remains unclear ... The results revealed that L. reuteri J1 prevented weight
gain, lowered fat mass and relieved dyslipidemia, and improved glucose
homeostasis and insulin sensitivity ... These results demonstrated that L.
reuteri J1 could treat obesity by inhibiting the FXR signaling pathways and
remodeling white adipose tissue, linked with UDCA and LCA which are affected by
intestinal microbiota"
-
Alteration of Gut Microbiota
in Alzheimer's Disease and Their Relation to the Cognitive Impairment -
J Alzheimers Dis 2022 Jun 20 - "The current work
highlighted a significant relationship between AD and gut microbiota dysbiosis.
A higher abundance of Prevotella species and lactic acid bacteria was correlated
with cognition"
-
Probiotic Bifidobacterium
breve MCC1274 Mitigates Alzheimer's Disease-Related Pathologies in Wild-Type
Mice - Nutrients 2022 Jun 19 - "Probiotics improve
brain function, including memory and cognition, via the microbiome-gut-brain
axis. Oral administration of Bifidobacterium breve MCC1274 (B. breve MCC1274)
improves cognitive function in AppNL-G-F mice and mild cognitive impairment
(MCI) subjects, and mitigates Alzheimer's disease (AD)-like pathologies ...
These findings suggest that B. breve MCC1274 may mitigate AD-like pathologies in
WT mice by decreasing Aβ42 levels, inhibiting tau phosphorylation, attenuating
neuroinflammation, and improving synaptic protein levels"
-
Lactobacillus reuteri J1
prevents obesity by altering the gut microbiota and regulating bile acid
metabolism in obese mice - Food Funct 2022 Jun 1 -
"Probiotics are now used as a treatment for obesity, but the mechanism by which
probiotics treat obesity remains unclear. Herein, we investigated the effects of
Lactobacillus reuteri J1 ( L. reuteri J1) on obese mice with the strain being
administered at 1010, 109 and 108 CFU mL-1 and explored the possible underlying
molecular mechanism. The results revealed that L. reuteri J1 prevented weight
gain, lowered fat mass and relieved dyslipidemia, and improved glucose
homeostasis and insulin sensitivity. Moreover, the effect of obesity reversal
exhibited dose-dependence to some extent. More importantly, mice treated with L.
reuteri J1 altered the gut microbiota and bile acid (BA) composition. Analysis
of the gut microbiome showed that L. reuteri J1 increased the relative
abundances of Lactobacillus, Akkermansia and Clostridium, which strongly
correlated with ursodeoxycholic acid (UDCA) and lithocholic acid (LCA)" -
See probiotic supplements at Amazon.com.
-
Intestinal Flora Mediates
Antiobesity Effect of Rutin in High-Fat-Diet Mice - Mol Nutr Food Res 2022
May 26 - "Intestinal flora plays a critical role in the
development of diet-induced obesity and related metabolic complications. Rutin
is a natural flavonoid with potential prebiotic effects on regulating the
intestinal flora composition that is beneficial for host health ... Rutin can be
considered as a prebiotic agent for improving intestinal flora disorders and
obesity-associated metabolic perturbations in obese individuals" - See
rutin at Amazon.com.
-
Lactiplantibacillus
plantarum J-15 reduced calcium oxalate kidney stones by regulating intestinal
microbiota, metabolism, and inflammation in rats - FASEB J 2022 Jun -
"The
prevention role of Lactiplantibacillus plantarum against the formation of kidney
stones has been increasingly recognized; its mechanism, however, has mainly been
focused on inhibiting the inflammation in the colon in the gastrointestinal (GI)
system, and the intestinal metabolites from microflora have not been revealed
fully with regarding to the stone formation ... L. plantarum J-15 effectively
reduced renal crystallization and urinary oxalic acid. Ten microbial genera,
including anti-inflammatory and SCFAs-related Faecalibaculum, were enriched in
the J-15 treatment group. There are 136 metabolites from 11 categories
significantly different in the J-15 supplementation group compared with CaOx
model rats, most of which were enriched in the amino acid metabolic and
secondary bile acid pathways. The expression of intestinal tight junction
protein Occludin and the concentration of pro-inflammatory cytokines and
prostaglandin were decreased in the intestine, which further reduced the
translocated lipopolysaccharide and inflammation levels in the blood upon J-15
treatment. Thus, the inflammation and injury in the kidney might be alleviated
by downregulating TLR4/NF-κB/COX-2 signaling pathway. It suggested that L.
plantarum J-15 might reduce kidney stone formation by restoring intestinal
microflora and metabolic disorder, protecting intestinal barrier function, and
alleviating inflammation. This finding provides new insights into the therapies
for renal stones" - See
Lactiplantibacillus plantarum at Amazon.com.
-
Docosahexaenoic acid-acylated
curcumin diester alleviates cisplatin-induced acute kidney injury by regulating
the effect of gut microbiota on the lipopolysaccharide- and trimethylamine-
N-oxide-mediated PI3K/Akt/NF-κB signaling pathway in mice - Food Funct 2022
May 16 - "An increasing number of studies have reported
the effects of curcumin (Cur) and docosahexaenoic acid (DHA) on alleviating
acute kidney injury (AKI) ... An increasing number of studies have reported the
effects of curcumin (Cur) and docosahexaenoic acid (DHA) on alleviating acute
kidney injury (AKI). In this work, we have performed a comparative investigation
to determine the effect of dietary DHA-acylated Cur esters, ester derivatives of
Cur, and recombination of curcumin and DHA on alleviating acute kidney injury in
a mouse model induced by a single intraperitoneal injection with cisplatin (20
mg kg-1). The results showed that the DHA-acylated Cur diesters significantly
decreased the abnormally increased blood urea nitrogen, creatinine,
lipopolysaccharide (LPS) and trimethylamine-N-oxide (TMAO) in serum caused by
AKI ... the DHA-acylated Cur diester treatment remarkably changed the relative
abundance of microbiota related to LPS and TMAO/trimethylamine (TMA) metabolism.
Moreover, dietary DHA-acylated Cur diesters clearly reduced the MDA content and
elevated GSH levels in the kidney of AKI mice, as well as changed the fatty acid
composition in the kidney. Further mechanism studies showed that DHA-acylated
Cur diesters significantly inhibited inflammation, apoptosis and oxidative
stress by preventing the LPS and TMAO-mediated PI3K/Akt/NF-κB signaling pathway.
The above results indicate that DHA-acylated Cur diesters are a potentially
novel candidate or targeted dietary pattern to prevent and treat drug-induced
acute kidney injury" - See docosahexaenoic acid at Amazon.com
and curcumin at Amazon.com.
-
Effect of Probiotic
Bifidobacterium breve in Improving Cognitive Function and Preventing Brain
Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a
24-Week Randomized, Double-Blind, Placebo-Controlled Trial - J Alzheimers
Dis 2022 May 7 - "Probiotics consumption for 24 weeks
suppressed brain atrophy progression, suggesting that B. breve MCC1274 helps
prevent cognitive impairment of MCI subjects"
-
Gut Microbiota and
Subjective Memory Complaints in Older Women - J Alzheimers Dis 2022 May 9 -
"Our findings support an association between alterations
in the gut bacterial composition and cognitive dysfunction"
-
Berberine as a Potential
Agent for the Treatment of Colorectal Cancer - Front Med (Lausanne) 2022 Apr
28 - "Numerous studies have shown that berberine (BBR)
is a safe and effective agent presenting significant antitumor effects ... The
review emphasizes several therapeutic effects of BBR and confirms that BBR could
suppress CRC by modulating gene expression, the cell cycle, the inflammatory
response, oxidative stress, and several signaling pathways. In addition, BBR
also displays antitumor effects in CRC by regulating the gut microbiota and
mucosal barrier function" - See berberine at Amazon.com.
-
Lactobacillus paracasei PS23
improves cognitive deficits via modulating the hippocampal gene expression and
the gut microbiota in D-galactose-induced aging mice - Food Funct 2022 Apr
19 - "Probiotic supplements are potential therapeutic
agents for age-related cognitive deficits. A prior study showed that probiotic
Lactobacillus paracasei PS23 (PS23) supplementation delayed age-related
cognitive decline in mice ... We revealed that PS23 and HK-PS23 supplementation
ameliorated D-gal-induced memory deficits and improved motor and
anxiety-behaviors in aging mice. In the hippocampus, serotonin levels (5-HT)
were increased and the genes involved in neuroplasticity, anti-inflammatory, and
antioxidant functions were upregulated in PS23 and HK-PS23 supplemented groups.
The gut microbiota showed specific changes. Our results suggest that PS23 and
HK-PS23 supplements could ameliorate age-related cognitive decline, possibly by
upregulating the genes involved in synaptic plasticity and preventing oxidation
and inflammation"
-
The relationship between the
gut microbiota, benign prostatic hyperplasia, and erectile dysfunction - Int
J Impot Res 2022 Apr 13 - "Microbiota is defined as the
group of commensal microorganisms that inhabit a specific human body site. The
composition of each individual's gastrointestinal microbiota is influenced by
several factors such as age, diet, lifestyle, and drug intake, but an increasing
number of studies have shown that the differences between a healthy microbiota
and a dysbiotic one can be related to different diseases such as benign
prostatic hyperplasia (BPH) and erectile dysfunction (ED) ... Gut microbiota
modifications can influence prostate health indirectly by the activation of the
immune system and the production of proinflammatory cytokines such as IL-17,
IL-23, TNF-alpha, and IFN-gamma, which are able to promote an inflammatory
state. Gut dysbiosis may lead to the onset of ED by the alteration of hormone
levels and metabolic profiles, the modulation of stress/anxiety-mediated sexual
dysfunction, the development of altered metabolic conditions such as obesity and
diabetes mellitus, and the development of hypertension. In conclusion, much
evidence suggests that the intestinal microbiota has an influence on various
pathologies including BPH and ED"
-
The relationship between the
gut microbiota, benign prostatic hyperplasia, and erectile dysfunction - Int
J Impot Res 2022 Apr 13 - "Microbiota is defined as the
group of commensal microorganisms that inhabit a specific human body site. The
composition of each individual's gastrointestinal microbiota is influenced by
several factors such as age, diet, lifestyle, and drug intake, but an increasing
number of studies have shown that the differences between a healthy microbiota
and a dysbiotic one can be related to different diseases such as benign
prostatic hyperplasia (BPH) and erectile dysfunction (ED) ... Gut microbiota
modifications can influence prostate health indirectly by the activation of the
immune system and the production of proinflammatory cytokines such as IL-17,
IL-23, TNF-alpha, and IFN-gamma, which are able to promote an inflammatory
state. Gut dysbiosis may lead to the onset of ED by the alteration of hormone
levels and metabolic profiles, the modulation of stress/anxiety-mediated sexual
dysfunction, the development of altered metabolic conditions such as obesity and
diabetes mellitus, and the development of hypertension. In conclusion, much
evidence suggests that the intestinal microbiota has an influence on various
pathologies including BPH and ED" - See
probiotic supplements at Amazon.com.
-
Probiotics' effect on
visceral and subcutaneous adipose tissue: a systematic review of randomized
controlled trials - Eur J Clin Nutr 2022 Apr 13 -
"Probiotics are shown to alter the microbiota, leading to a favorable
environment, in which weight loss and metabolic parameters are improve. However,
the results on probiotics' effect on specific types of central adipose tissues,
mainly visceral (VAT) and subcutaneous adipose tissue (SAT), are conflicting ...
For VAT, overall, there was a significant decrease (DM = -3.63 cm2, 95% CI:
-5.08 to -2.17, p < 0.001). When stratified by type of probiotic, single
Bifidobacterium (DM = -4.49 cm2, 95% CI:-7.37 to -1.61, p = 0.002) and single
Lactobacillus probiotics (DM = -3.84 cm2, 95% CI:-5.74 to -1.93, p < 0.001)
resulted in significant reductions. Mixed probiotics had no effect. For SAT,
overall, there was a significant decrease (DM = -2.91 cm2, 95% CI:-4.82 to
-1.01, p = 0.003), and when stratified by type of probiotic, single
Lactobacillus (DM = -3.39 cm2, 95% CI:-5.90 to -0.88, p = 0.008) and mixed
probiotics (DM = -5.97 cm2, 95% CI:-10.32 to -1.62, p = 0.007) resulted in a
significant decrease. Single Bifidobacterium probiotics had no effect. Using
meta-regression, no association was observed between the total daily probiotic
dose and VAT or SAT reduction" - See
Lactobacillus at Amazon.com.
-
Lactobacillus paracasei 24
Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating
the Gut Microbiota - J Agric Food Chem 2022 Apr 4 -
"Obesity has become a worldwide public health problem. Lactic acid bacteria have
attracted extensive attention for alleviating obesity and fat accumulation. This
study aimed to evaluate the alleviating effects of Lactobacillus paracasei 24
(LP24) on lipid accumulation in an obese mouse model induced by a high-fat diet
(HFD). The results showed that LP24 treatment significantly reduced body weight
and fat deposition in HFD mice, improved blood lipid levels and liver steatosis,
reduced liver oxidative stress injury and the inflammatory response, and
regulated fat metabolism-related factors. Moreover, LP24 regulated the abundance
and diversity of the gut microbiota, reduced the abundance of Firmicutes and the
ratio of Firmicutes/Bacteroidetes (F/B), and increased the abundance of
Akkermansia" - See probiotic supplements at Amazon.com.
-
Relationship Between the Gut
Microbiota and Alzheimer's Disease: A Systematic Review - J Alzheimers Dis
2022 Mar 2 - "The results of these studies support the
hypothesis that there is a relationship between the gut microbiota and cognitive
disorders through the gut-brain axis. However, today, there is a substantial
lack of human studies, especially clinical trials, which makes it difficult to
formulate clinical recommendations on this topic"
-
Tryptophan Supplementation
Increases the Production of Microbial-Derived AhR Agonists in an In Vitro
Simulator of Intestinal Microbial Ecosystem - J Agric Food Chem 2022 Mar 28
- "The aryl hydrocarbon receptor (AhR) plays an
important role in intestinal homeostasis, and some microbial metabolites of
tryptophan are known AhR agonists. In this study, we assessed the impact of
tryptophan supplementation on the formation of tryptophan metabolites, AhR
activation, and microbiota composition in the simulator of the human intestinal
microbial ecosystem (SHIME) ... Tryptophan supplementation induced most
microbial changes in the transverse colon including increased relative abundance
of lactobacillus. We conclude that tryptophan supplementation leads to increased
formation of AhR agonists in the colon" - See
tryptophan at Amazon.com.
-
The role of microbiota in
nonalcoholic fatty liver disease (NAFLD) - Eur J Clin Invest 2022 Mar 16 -
"NAFLD is the most frequent liver disease worldwide. Gut
microbiota can play a role in the pathogenesis of NAFLD since dysbiosis is
associated with reduced bacterial diversity, altered Firmicutes/Bacteroidetes
ratio, a relative abundance of alcohol-producing bacteria, or other specific
genera. Changes can promote disrupted intestinal barrier and hyperpermeability,
filtration of bacterial products, activation of the immune system, and
pro-inflammatory changes in the intestine, in the liver, and at a systemic
level. Microbiota-derived molecules can contribute to the steatogenic effects.
The link between gut dysbiosis and NAFLD, however, is confused by several
factors which include age, BMI, comorbidities, dietary components, and
lifestyle. The role of toxic chemicals in food and water requires further
studies in both gut dysbiosis and NAFLD. We can anticipate that gut microbiota
manipulation will represent a potential therapeutic tool to delay or reverse the
progression of NAFLD, paving the way to primary prevention measures" -
See probiotic supplements at Amazon.com.
-
Influence of
the Microbiota-Gut-Brain Axis on Cognition in Alzheimer's
Disease - J Alzheimers Dis 2022 Mar 2 -
"few of these interventions, such as
probiotics, are promising candidates for the improvement of
cognition in Alzheimer 's disease and are the focus of this
review"
-
Restorative
effects of probiotics on memory impairment in sleep-deprived
mice - Nutr Neurosci 2022 Mar 3 -
"These findings demonstrate that Lpc-37 and the multi-strain may
play a role in alleviating memory impairments and improve
cognitive function in partially sleep-deprived mice"
-
Probiotics counteract
hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a
model of infantile epilepsy - EBioMedicine 2022 Feb 8 -
"Our results suggest that early intervention with
probiotics could be considered as an approach to reduce the risk of hepatic side
effects of the KD in children who are on the diet for medically indicated
reasons"
-
Gut
microbiota in patients with Alzheimer's disease spectrum: a
systematic review and meta-analysis - Aging (Albany NY) 2022
Jan 14 - "gut microbiota (GM) ... 11
studies consisting of 378 HC and 427 patients with AD spectrum
were included in the meta-analysis. Patients with AD, but not
MCI, showed significantly reduced GM diversity as compared to
HC. We also found more abundance of Proteobacteria,
Bifidobacterium and Phascolarctobacterium, but less abundance of
Firmicutes, Clostridiaceae, Lachnospiraceae and Rikenellaceae in
patients with AD spectrum as compared with HC. The profiles of
abundance of Alistipes and Bacteroides in HC and AD spectrum
were differentially affected by countries. Finally, when
considering clinical stage as a moderator, the comparisons of
abundance in Clostridiaceae and Phascolarctobacterium showed
large effect sizes, with gradient changes from MCI to AD stage"
-
Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in
MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative
Damage, Inflammation, and Gut Microbiota Disorder - J Agric
Food Chem 2022 Jan 24 - "Our results
suggested that L. plantarum DP189 could delay the
neurodegeneration caused by the accumulation of α-SYN in the SN
of PD mice via suppressing oxidative stress, repressing
proinflammatory response, and modulating gut microbiota"
-
A Specifically Tailored
Multistrain Probiotic and Micronutrient Mixture Affects Nonalcoholic Fatty Liver
Disease-Related Markers in Patients with Obesity after Mini Gastric Bypass
Surgery - J Nutr 2021 Nov 22 - "Nonalcoholic fatty
liver disease (NAFLD) is frequent among patients undergoing bariatric surgery.
Beyond weight reduction, dietary supplements like micronutrients or probiotics
that modify insulin resistance and lipotoxicity can be used to prevent or delay
the progression of liver disease ... Patients received a combination of
specifically tailored multistrain probiotic powder and a specific micronutrient
mixture (Pro+SM) or a control treatment consisting of a placebo and a basic care
micronutrient mixture (Con+BM), with some micronutrients in lower doses than SM,
for 12 wk after hospital discharge ... Compared with Con+BM, Pro+SM improved
serum ASAT (difference: -8.0 U/L, 95% CI: -17.0, -4.0; P = 0.043), NAFLD
fibrosis score (difference: -0.39; 95% CI: -0.78, 0; P = 0.048), serum
triglycerides (difference: -22.8 mg/dL; 95% CI: -45.6, -0.1; P = 0.049) and the
visceral adiposity index (difference: -0.70"
-
Probiotic Releasing
Angiotensin (1-7) in a Drosophila Model of Alzheimer's Disease Produces
Sex-Specific Effects on Cognitive Function - J Alzheimers Dis 2021 Dec 15 -
"While extensive research on the brain has failed to
identify effective therapies, using probiotics to target the gut microbiome has
shown therapeutic potential in Alzheimer's disease (AD)"
-
Role of the microbiota in
hypertension and antihypertensive drug metabolism - Hypertens Res 2021 Dec 9
- "In this review, we provide insights into
host-microbiota interactions and summarize the evidence supporting the
importance of the microbiota in blood pressure (BP) regulation. Metabolites
produced by the gut microbiota, especially short-chain fatty acids (SCFAs),
modulate BP and vascular responses. Harmful gut-derived metabolites, such as
trimethylamine N-oxide and several uremic toxins, exert proatherosclerotic,
prothrombotic, and proinflammatory effects. High-salt intake alters the
composition of the microbiota, and this microbial alteration contributes to the
pathogenesis of salt-sensitive hypertension. In addition, the microbiota may
impact the metabolism of drugs and steroid hormones in the host. The
drug-metabolizing activities of the microbiota affect the pharmacokinetic
parameters of antihypertensive drugs and contribute to the pathogenesis of
licorice-induced pseudohyperaldosteronism. Furthermore, the oral microbiota
plays a role in BP regulation by producing nitric oxide, which lowers BP via its
vasodilatory effects. Thus, antihypertensive intervention strategies targeting
the microbiota, such as the use of prebiotics, probiotics, and postbiotics
(e.g., SCFAs), are considered new therapeutic options for the treatment of
hypertension" - See
Probiotic supplements at Amazon.com,
Prebiotic supplements at
Amazon.com and postbiotics at
Amazon.com.
-
Prevention of Atopic
Dermatitis in Mice by Lactobacillus Reuteri Fn041 Through Induction of
Regulatory T Cells and Modulation of the Gut Microbiota - Mol Nutr Food Res
2021 Nov 26 - "The development of atopic dermatitis (AD)
in infants is closely related to the lagging development of intestinal
microbiota, including that inoculated by breast milk bacteria, and immune
development. Lactobacillus reuteri Fn041 is a secretory immunoglobulin A (sIgA)
-coated bacterium derived from human milk ... Our study strengthens the
understanding that breast milk-derived sIgA coated potential probiotics are
involved in the development of infant intestinal microbiota, thus promoting
immune development and preventing allergic diseases, and expanding the knowledge
of breast milk sIgA and bacterial interactions on infant immune development"
-
Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in
ovariectomized mice J Func Foods, 12/21 -
"Osteoporosis is a common skeletal disease in which bone resorption exceeds bone
formation. Intestinal health has been linked to reduced osteoporosis. The aim of
this study was to compare the anti-osteoporotic and intestinal health effects of
two strains of Lactobacillus plantarum (AR237 and AR495) in ovariectomized (ovx)
C57BL/6 mice. The results showed that AR495 significantly inhibited ovx-induced
bone loss, reduced intestinal permeability, increased the expression of tight
junction proteins, claudin-family proteins, zonula occludens-1 (ZO-1), and
junctional adhesion molecule 3 (JAM-3) in ovx mice. Furthermore, AR495 inhibited
bone resorption by modulating the receptor activator for nuclear factor kappa B
(RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system, and ameliorated ovx-induced
intestinal inflammatory responses. AR495 improved intestinal microbial
stability, and increased the abundance of short-chain fatty acids
(SCFA)-producing bacteria and fecal SCFA content of ovx mice. Overall, the
findings of this study showed that AR495 was more effective than AR237 at
treating osteoporosis" - [Nutra
USA]
-
Lactobacillus plantarum
DP189 prevents cognitive dysfunction in D-galactose/AlCl 3 induced mouse model
of Alzheimer's disease via modulating gut microbiota and PI3K/Akt/GSK-3β
signaling pathway - Nutr Neurosci 2021 Nov 10 -
"Increased levels of serotonin, dopamine, and gamma-aminobutyric acid positively
affected the pathological processes by ameliorating neuronal damage,
beta-amyloid deposition, and tau pathology. L. plantarum DP189 intervention
simultaneously modulated the gut microbial communities to alleviate gut
dysbiosis. Moreover, L. plantarum DP189 inhibited tau hyperphosphorylation by
regulating the PI3 K/Akt/GSK-3β pathway. These findings indicated that L.
plantarum DP189 intervention is a promising therapeutic strategy to prevent the
onset and development of AD."
-
The Effect of Probiotics in
Stroke Treatment - Evid Based Complement Alternat Med 2021 Oct 28 -
"enteral nutrition (EN) ... The probiotics combined with
EN group's therapeutic effects were superior to those of the EN alone. Thus,
probiotics combined with EN is worthy of both clinical application and promotion
in stroke treatment"
-
Understanding the gut
microbiota and sarcopenia: a systematic review - J Cachexia Sarcopenia
Muscle 2021 Sep 14 - "Altering the gut microbiota
through bacteria depletion, faecal transplantation, and various supplements was
shown to directly affect muscle phenotypes. Probiotics, prebiotics, SCFAs, and
bacterial products are potential novel therapies to enhance muscle mass and
physical performance. Lactobacillus and Bifidobacterium strains restored
age-related muscle loss. Potential mechanisms of microbiome modulating muscle
mainly include protein, energy, lipid, and glucose metabolism, inflammation
level, neuromuscular junction, and mitochondrial function. The role of the gut
microbiota in the development of muscle loss during aging is a crucial area that
requires further studies for translation to patients"
-
The Effect of Probiotics
(MCP® BCMC® Strains) on Hepatic Steatosis, Small Intestinal Mucosal Immune
Function, and Intestinal Barrier in Patients with Non-Alcoholic Fatty Liver
Disease - Nutrients 2021, 13(9) - "Treatment for
non-alcoholic fatty liver disease (NAFLD) currently consists of lifestyle
modifications such as a low-fat diet, weight loss, and exercise. The gut
microbiota forms part of the gut–liver axis and serves as a potential target for
NAFLD treatment ... This was a randomized, double-blind, placebo-controlled
trial involving ultrasound-diagnosed NAFLD patients (n = 39) who were
supplemented with either a probiotics sachet (MCP® BCMC® strains) or a placebo
for a total of 6 months. Multi-strain probiotics (MCP® BCMC® strains) containing
six different Lactobacillus and Bifidobacterium species at a concentration of 30
billion CFU were used ... In this pilot study, the use of probiotics did not
result in any significant clinical improvement in NAFLD patients. However, at
the microenvironment level (i.e., the small intestinal mucosa), probiotics
seemed to be able to stabilize the mucosal immune function and to protect NAFLD
patients against increased intestinal permeability. Therefore, probiotics might
have a complementary role in treating NAFLD" - [Nutra
USA]
-
Gut
microbiota influences the ability to lose weight - Science Daily, 9/13/21 -
"The researchers focused on 48 individuals who lost more
than 1% of their body weight per month over a 6 to 12 month period and 57
individuals who did not lose any weight and had a stable body mass index (BMI)
over the same period. The researchers relied on metagenomics, the study of
genetic material recovered from blood and stool samples. The individuals
analyzed blood metabolites, blood proteins, clinical labs, dietary
questionnaires and gut bacteria in the two groups ... After controlling for age,
sex and baseline BMI, the researchers identified 31 baseline stool metagenomic
functional features that were associated with weight loss responses. These
included complex polysaccharide and protein degradation genes, stress-response
genes, respiration-related genes, cell wall synthesis genes and gut bacterial
replication rates. A major finding was that the ability of the gut microbiome to
break down starches was increased in people who did not lose weight. Another key
finding was that genes that help bacteria grow faster, multiply, replicate and
assemble cell walls were increased in people who lost more weight ... Research
has already shown that if you change your diet, you can alter the composition of
bacteria in your gut. According to Dr. Diener, if someone has a composition of
gut bacterial genes that confers resistance to weight loss, then perhaps you can
alter their diet to shift to a composition that would help them lose weight"
-
Gut
bacteria influence brain development - Science Daily, 9/3/21 -
"The early development of the gut, the brain and
the immune system are closely interrelated. Researchers refer to this as the
gut-immune-brain axis. Bacteria in the gut cooperate with the immune system,
which in turn monitors gut microbes and develops appropriate responses to them
... The microorganisms of the gut microbiome -- which is a vital collection of
hundreds of species of bacteria, fungi, viruses and other microbes -- are in
equilibrium in healthy people. However, especially in premature babies, whose
immune system and microbiome have not been able to develop fully, shifts are
quite likely to occur. These shifts may result in negative effects on the brain"
-
Beneficial effects of a combination of Clostridium cochlearium and Lactobacillus
acidophilus on body weight gain, insulin sensitivity and gut microbiota in
high-fat diet induced obese mice Nutrition, 4 Aug 21 -
"Species L. acidophilus and butyrate producer C.
cochlearium have been shown potential anti-obesity effects. We hypothesized that
the combination of C. cochlearium and L. acidophilus (CC-LA) has beneficial
effects on body weight control and glucose homeostasis in high-fat diet induced
obese (DIO) mice ... thirty-six 6-week-old male C57BL/6 mice were randomly
assigned to three groups (n = 12). The experimental group (CC-LA) was
administered with CC-LA mixture and fed ad libitum with high-fat diet. High-fat
diet (HF) control and low-fat diet (LF) control groups were treated with the
same dose of sterile water as CC-LA group. After 17 weeks of dietary
intervention, the CC-LA group showed 17% less body weight gain than the HF group
did ... This study provided evidence that the CC-LA combination reduced obesity
and improved glucose metabolism in high fat diet treated DIO mice, potentially
mediated by the modulation of gut microbiota" - [Nutra
USA]
-
Probiotics as a New
Regulator for Bone Health: A Systematic Review and Meta-Analysis - Evid
Based Complement Alternat Med 2021 Aug 2 - "Spinal and
total hip bone mineral density (BMD) was not affected significantly by probiotic
consumption. In 37 animal experiments, probiotic or symbiotic feeding mostly had
effects on bone health parameters. Some strains of Bifidobacterium and
Lactobacillus including L. reuteri, L. casei, L. paracasei, L. bulgaricus, and
L. acidophilus have indicated beneficial effects on bone health parameters. In
conclusion, this systematic review and meta-analysis indicate that probiotic
supplementation might improve bone health" - See
probiotic supplements at Amazon.com
and
iHerb.
-
Effect of probiotics
supplementation on disease progression, depression, general health, and
anthropometric measurements in relapsing-remitting multiple sclerosis patients:
A systematic review and meta-analysis of clinical trials - Int J Clin Pract
2021 Aug 11;e14724 - "Probiotics may have a promising
role in chronic autoinflammatory diseases. The current systematic review and
meta-analysis investigated the effects of probiotics on disease progression,
depression, general health, and anthropometric measurements in
Relapsing-Remitting Multiple Sclerosis (RRMS) patients ... Our findings revealed
that probiotics supplementation can improve disease progression, suppress
depression, and general health in MS patients"
-
Lactobacillus johnsonii
Attenuates Citrobacter rodentium-Induced Colitis by Regulating Inflammatory
Responses and Endoplasmic Reticulum Stress in Mice - J Nutr 2021 Aug 12 -
"Probiotics are beneficial in intestinal disorders.
However, the benefits of Lactobacillus johnsonii in experimental colitis remain
unknown ... L. johnsonii supplementation is a promising nutritional strategy for
preventing C. rodentium-induced colitis in mice" - See
Lactobacillus johnsonii at Amazon.com.
-
Effects of Lactobacillus
plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported
Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial -
Nutrients 2021, 13(8) - "Recent animal studies have
supported that Lactobacillus plantarum PS128 (PS128) can reduce the severity of
anxiety and depression. However, previous studies did not focus on the sleep
quality and mood of humans ... Forty participants between 20 and 40 years of age
with self-reported insomnia were randomly assigned to two groups, a PS128 group
and a placebo group, in a double-blind trial. Participants took two capsules of
either PS128 or a placebo after dinner for 30 day ... Compared to the control
group, the PS128 group showed significant decreases in Beck Depression
Inventory-II scores, fatigue levels, brainwave activity, and awakenings during
the deep sleep stage. Their improved depressive symptoms were related to changes
in brain waves and sleep maintenance. These findings suggest that daily
administration of PS128 may lead to a decrease in depressive symptoms, fatigue
level, cortical excitation, and an improvement in sleep quality during the deep
sleep stage. Daily consumption of PS128 as a dietary supplement may improve the
depressive symptoms and sleep quality of insomniacs, although further
investigation is warranted" - [Nutra
USA] - See lactobacillus plantarum ps128
at Amazon.com.
-
Combination
of Limosilactobacillus fermentum MG4231 and MG4244 attenuates lipid accumulation
in high-fat diet-fed obese mice - Benef Microbes 2021 Aug 4 -
"Administration of the Limosilactobacillus strains
decreased body weight gain, liver and adipose tissue weight, and glucose
tolerance. Serum levels of total cholesterol, low-density
lipoprotein-cholesterol, and leptin were reduced, while adiponectin increased.
The administration of Limosilactobacillus strains improved the histopathological
features of liver tissue, such as hepatic atrophy and inflammatory penetration,
and significantly reduced the content of triglyceride in the liver.
Limosilactobacillus administration discovered a significant reduction in the
size of the adipocytes in the epididymal tissue. Limosilactobacillus treatment
significantly reduced the expression of important regulators in lipid
metabolism, including peroxisome proliferator-activated receptor γ,
CCAAT/enhancer-binding protein α, fatty acid synthase (FAS), adipocyte-protein
2, and lipoprotein lipase in the epididymal tissue. Also, Limosilactobacillus
lowered sterol regulatory element-binding protein 1-c and FAS in the liver
tissue" - [Nutra
USA]
-
Effects of probiotics on
body adiposity and cardiovascular risk markers in individuals with overweight
and obesity: A systematic review and meta-analysis of randomized controlled
trials - Clin Nutr 2021 Jul 3 - "Evidence suggests
that gut microbiota is a potential factor in the pathophysiology of both obesity
and related metabolic disorders ... The present meta-analysis suggests that
probiotics consumption may be helpful for improving body weight, body adiposity
and some CVD risk markers in individuals with overweight and obesity" -
See probiotic supplements at Amazon.com
and
iHerb.
-
Effects of Lactococcus
lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute
psychological stress in healthy Japanese men - Eur J Clin Nutr 2021 Aug 4 -
"Lactococcus lactis subsp. cremoris (YRC3780), which is
isolated from kefir, has been associated with anti-allergic effects in humans
... Our study suggests that daily intake of YRC3780 improves the HPA axis
response to acute psychological stress, which might be associated with a
decrease in morning cortisol levels" - See
kefir at Amazon.com.
-
Gut Microbiota and
Pathophysiology of Depressive Disorder - Ann Nutr Metab 2021 Jul 28 -
"Accumulating evidence has suggested that the
bi-directional communication pathway, the microbiota-gut-brain axis, plays an
important role in the pathophysiology of many neuropsychiatric diseases
including major depressive disorder (MDD) ... There are at least 4 key
biological molecules/systems underlying the pathophysiology of MDD: central
dopamine, stress responses by the hypothalamic-pituitary-adrenal axis and
autonomic nervous system, inflammation, and brain-derived neurotrophic factor.
Animal experiments in several depression models have clearly indicated that gut
microbiota is closely related to these molecules/systems and administration of
probiotics and prebitotics may have beneficial effects on them ... Clinical
trials of probiotics have emerged, and the majority of the studies have reported
beneficial effects on depression symptoms and related biological markers. Key
Messages: The accumulating evidence suggests that research on the
microbiota-gut-brain axis in major depressive disorder (MDD) is promising to
elucidate the pathophysiology and to develop novel treatment of MDD, although
there is still a long distance yet to reach the goals"
-
The
Effects of Limosilactobacillus reuteri LR-99 Supplementation on Body Mass Index,
Social Communication, Fine Motor Function, and Gut Microbiome Composition in
Individuals with Prader–Willi Syndrome: a Randomized Double-Blinded
Placebo-Controlled Trial - Probiotics Antimicrob Proteins 2021 Jun 11 -
"Prader-Willi
syndrome (PWS) is a rare genetic disorder associated with developmental delay,
obesity, and neuropsychiatric comorbidities. Limosilactobacillus reuteri
(Lactobacillus reuteri, Lact. reuteri) has demonstrated anti-obesity and
anti-inflammatory effects in previous studies. In the present study, we aim to
evaluate the effects of Lact. reuteri supplementation on body mass index (BMI),
social behaviors, and gut microbiota in individuals with PWS ... Participants
were randomly assigned to either receive daily Lact. reuteri LR-99 probiotic (6
× 1010 colony forming units) or a placebo sachet ... We found a significant
reduction in BMI for the probiotic group at both 6 weeks and 12 weeks relative
to the baseline (P < 0.05). Furthermore, we observed a significant improvement
in social communication and interaction, fine motor function, and total ASQ-3
score in the probiotics group compared to the placebo group (P < 0.05). Altered
gut microbiota was observed in the probiotic group to favor weight loss and
improve gut health. The findings suggest a novel therapeutic potential for Lact.
reuteri LR-99 probiotic to modulate BMI, social behaviors, and gut microbiota in
Prader-Willi syndrome patients, although further investigation is warranted" -
[Nutra USA] - See
Limosilactobacillus reuteri at Amazon.com.
-
Effects of Probiotic NVP-1704
on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized,
Double-Blind, Placebo-Controlled Trial - Nutrients 2021, 13(8) -
"The human gut microbiome is closely linked to mental
health and sleep. We aimed to verify the efficacy and safety of probiotic
NVP-1704, a mixture of Lactobacillus reuteri NK33 and Bifidobacterium
adolescentis NK98, in improving stress, depression, anxiety, and sleep
disturbances, along with the measurement of some blood biomarkers. A total of
156 healthy adults with subclinical symptoms of depression, anxiety, and
insomnia were retrospectively registered and randomly assigned to receive either
NVP-1704 (n = 78) or a placebo (n = 78) for eight week ... After intervention,
gut microbiota composition was quantified by pyrosequencing the bacterial 16S
rRNA gene. The NVP-1704 group had a more significant reduction in depressive
symptoms at four and eight weeks of treatment, and anxiety symptoms at four
weeks compared to the placebo group. Those receiving NVP-1704 also experienced
an improvement in sleep quality. NVP-1704 treatment led to a decrease in serum
interleukin-6 levels. Furthermore, NVP-1704 increased Bifidobacteriaceae and
Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota
composition. Our findings suggest that probiotic NVP-1704 could be beneficial
for mental health and sleep" - [Nutra
USA]
-
Effect of probiotic
supplementation along with calorie restriction on metabolic endotoxemia, and
inflammation markers in coronary artery disease patients: a double blind placebo
controlled randomized clinical trial - Nutr J 2021 Jun 1 -
"Alterations in the gut microbiome (dysbiosis) has been
associated with increased microbial translocation, leading to chronic
inflammation in coronary artery disease (CAD). It has been proposed that
modulation of gut microbiota by probiotic might modify metabolic endotoxemia ...
These data provide preliminary evidence that probiotic supplementation has
beneficial effects on metabolic endotoxemia, and mega inflammation in
participants with CAD"
-
Probiotics Can Further
Reduce Waist Circumference in Adults with Morbid Obesity after Bariatric
Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Evid Based Complement Alternat Med 2021 Apr 1 - "Probiotics
aid adults with morbid obesity in achieving further waist circumference
improvement after BS, with no significant effect on weight, BMI, %EWL, and CRP"
-
Mendelian Randomization
Analysis Reveals Causal Effects of the Human Gut Microbiota on Abdominal Obesity
- J Nutr 2021 Mar 24 - "trunk fat mass (TFM) ... Our
findings provided evidence of a causal association between gut microbiota and
TFM in UK adults and identified specific bacteria taxa that may regulate the fat
metabolism, thus offering new direction for the treatment of obesity"
-
Dissecting the contribution
of host genetics and the microbiome in complex behaviors - Cell 2021 Mar 4 -
"The core symptoms of many neurological disorders have
traditionally been thought to be caused by genetic variants affecting brain
development and function. However, the gut microbiome, another important source
of variation, can also influence specific behaviors. Thus, it is critical to
unravel the contributions of host genetic variation, the microbiome, and their
interactions to complex behaviors. Unexpectedly, we discovered that different
maladaptive behaviors are interdependently regulated by the microbiome and host
genes in the Cntnap2-/- model for neurodevelopmental disorders. The
hyperactivity phenotype of Cntnap2-/- mice is caused by host genetics, whereas
the social-behavior phenotype is mediated by the gut microbiome. Interestingly,
specific microbial intervention selectively rescued the social deficits in
Cntnap2-/- mice through upregulation of metabolites in the tetrahydrobiopterin
synthesis pathway. Our findings that behavioral abnormalities could have
distinct origins (host genetic versus microbial) may change the way we think
about neurological disorders and how to treat them"
-
Gut microbiota compositions
and metabolic functions in type 2 diabetes differ with glycemic durability to
metformin monotherapy - Diabetes Res Clin Pract 2021 Mar 4 -
"Metformin, the first-line treatment for type 2
diabetes, has been found to modulate the gut microbiota ... There were different
compositions of gut microbiota with unique microbial metabolic pathways between
type 2 diabetes with and without glycemic durability to metformin monotherapy.
Microbial salvage by increasing thiamine biosynthesis might be beneficial for
the metformin durable group to maintain optimal glycemic control"
-
The effects of
co-administration of probiotics and prebiotics on chronic inflammation, and
depression symptoms in patients with coronary artery diseases: a randomized
clinical trial - Nutr Neurosci 2021 Feb 28 - "we are
interested in exploring of anti-inflammatory and anti-depressant effects of
Lactobacillus Rhamnosus G (LGG), a probiotic strain, alone or in combination
with a prebiotic, Inulin, in patients with coronary artery disease (CAD) ...
This randomized, double-blind clinical trial was held on 96 patients with CAD.
Patients were randomly allocated into four different groups: LGG [a capsule/day,
contained 1.9 × 109 colony-forming unit of Lactobacillus Rhamnosus G], inulin
(15 g/day), co-supplemented (LGG and inulin), and placebo. Participants consumed
the supplements for two months. Beck Depression Inventory (BDI), MacNew
questionnaire and Spielberger state-trait anxiety inventory (STAI-Y) were used
to assess depression, quality of life and anxiety, respectively. Serum levels of
C-reactive protein (hs-CRP), lipopolysaccharide (LPS), tumor necrosis factor
(TNF)-α, and Interleukin (IL)-10 were also measured ... Co-supplementation of
probiotics and inulin in CAD subjects for eight weeks had beneficial effects on
depression, anxiety, and inflammatory biomarkers. Adding inulin to probiotic
supplements improved psychological outcomes and inflammatory biomarkers more
effectively than two supplements separately" - See
probiotic supplements at Amazon.com
and prebiotic supplements at
Amazon.com.
-
Gut microbiome
pattern reflects healthy ageing and predicts survival in humans - Nat Metab
2021 Feb;3(2):274-286 - "The identified microbiome pattern of healthy ageing is
characterized by a depletion of core genera found across most humans, primarily Bacteroides. Retaining a high Bacteroides dominance into older age, or having a
low gut microbiome uniqueness measure, predicts decreased survival in a 4-year
follow-up. Our analysis identifies increasing compositional uniqueness of the
gut microbiome as a component of healthy ageing, which is characterized by
distinct microbial metabolic outputs in the blood" - [Nutra
USA]
-
Probiotics as a
Complementary Therapy for Management of Obesity: A Systematic Review - Evid
Based Complement Alternat Med 2021 Jan 22 - "It seems
that the probiotic products could have beneficial effects as an adjunct therapy
for care and management of obesity when used in high dose. However, due to
heterogeneity of included studies, it is required to confirm our results by more
meta-analyses of clinical trials"
-
Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological
markers of stress and anxiety in healthy adults: a randomized, double-blind,
placebo-controlled and parallel clinical trial (the Sisu study) - Neurobiol
Stress. 2020 Nov 24 - "Chronic stress is a risk-factor
for the development of mood and stress-related disorders. Clinical evidence
indicates that probiotics can influence the stress response and mood. The Sisu
study investigated whether Lacticaseibacillus paracasei Lpc-37® (Lpc-37®) could
modulate stress, mood and well-being. Prior to a two-week run-in period, 120
healthy adults (18-45 y) were stratified for sex and chronic stress and
randomized to either 1.75 × 1010 colony forming units (CFU) of Lpc-37 or placebo
(1:1) per day for 5 weeks. The primary objective was the effect of Lpc-37 on
heart rate (HR) in response to the Trier Social Stress Test (TSST). Secondary
objectives were assessed by biomarkers and self-report scales over the study.
The primary hypothesis was not met in either the Intention-to-Treat (ITT) or Per
Protocol (PP) population, but Lpc-37 reduced the increase in HR in participants
with low chronic stress (LCS) and increased HR in participants with high chronic
stress (HCS) during the TSST. Supporting significant efficacy in the PP
population (n = 113), Lpc-37 reduced perceived stress following intervention.
More significant effects were identified within the subgroups where Lpc-37
reduced exhaustion during the TSST and normalized cortisol levels at 8pm in
participants with LCS, reduced perceived stress also in females, and increased
perceived health and sleep-related recovery in participants with HCS. Adverse
events (AEs) were similar between groups, there were no severe AEs, and vital
signs remained unchanged" - [Nutra
USA]
-
Effect of the Natural
Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A
Pilot Dose-Ranging Study - Nutrients 2021 Jan 8 -
"Sugar consumption is associated with a whole range of negative health effects
and should be reduced and the natural sweetener xylitol might be helpful in
achieving this goal ... Twelve healthy, lean volunteers received intragastric
solutions with 7, 17 or 35 g xylitol or tap water on four separate days ... low
doses of xylitol stimulate the secretion of gut hormones and induce a
deceleration in gastric emptying rates. There is no effect on blood lipids and
only little effect on plasma glucose and insulin. This combination of properties
(low-glycemic sweetener which stimulates satiation hormone release) makes
xylitol an attractive candidate for sugar replacement" - See
xylitol at Amazon.com.
-
Age-related cognitive
decline is associated with microbiota-gut-brain axis disorders and
neuroinflammation in mice - Behav Brain Res 2021 Jan 7 -
"We observed that aged mice exhibited significant
deficits in learning and memory, neuronal loss, and synaptic damage compared
with young mice. Aged mice also exhibited significant dysbiosis of the gut
microbiota. Disruptions of the intestinal barrier and blood-brain barrier were
also observed, including increases in intestinal, low-grade systemic and
cerebral inflammation. Furthermore, plasma and brain levels of
lipopolysaccharide (LPS) were significantly higher in aged mice compared with
young mice, with increases in the expression of Toll-like receptor 4 (TLR4) and
myeloid differential protein-88 (MyD88) and the nuclear translocation of nuclear
factor κB (NF-κB) in intestinal and brain tissues. These findings showed that
microbiota-gut-brain axis dysfunction that occurs through LPS-induced activation
of the TLR4/NF-κB signaling pathway is implicated in age-related
neuroinflammation and cognitive decline" - See
probiotic supplements at Amazon.com.
-
Probiotic
Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates
immune response with gut microbiota - Sci Rep 2020 Dec 10 -
"Increasing evidence indicates that alterations in gut
microbiota are associated with mammalian development and physiology. The gut
microbiota has been proposed as an essential player in metabolic diseases
including brain health ... Assessment of various behavioral and physiological
functions was performed using Y-maze tests, wheel running tests, accelerated
rotarod tests, balance beam tests, and forced swimming tests (FSTs), using adult
mice after 50 weeks of administering living probiotic bacterium Lactobacillus
fermentum strain JDFM216 or a vehicle. Immunomodulatory function was
investigated using immune organs, immune cells and immune molecules in the mice,
and gut microbiota was also evaluated in their feces. Notably, the L. fermentum
JDFM216-treated group showed significantly better performance in the behavior
tests (P < 0.05) as well as improved phagocytic activity of macrophages,
enhanced sIgA production, and stimulated immune cells (P < 0.05). In aged mice,
we observed decreases in species belonging to the Porphyromonadaceae family and
the Lactobacillus genus when compared to young mice. While administering the
supplementation of L. fermentum JDFM216 to aged mice did not shift the whole gut
microbiota, the abundance of Lactobacillus species was significantly increased
(P < 0.05). Our findings suggested that L. fermentum JDFM216 also provided
beneficial effects on the regulation of immune responses, which has promising
implications for functional foods. Taken together, L. fermentum JDFM216 could
confer the benefit of improving health with enhanced cognition, physiological
behavior, and immunity by modulating the gut microbiota" - [Nutra
USA]
-
Synergistic Therapeutic
Effects of Probiotic Lactobacillus casei TD-2 Consumption on GM-CSF-Induced
Immune Responses in a Murine Model of Cervical Cancer - Nutr Cancer 2020 Dec
26 - "Our findings showed that the combination of GM-CSF
and probiotic results in improved tumor suppression against HPV-associated
tumors and stimulates enhancement of specific antitumor immune responses."
-
The Microbiota-Gut-Brain
Axis and Alzheimer's Disease: Neuroinflammation Is to Blame? - Nutrients
2020 Dec 24 - "microbiota-gut-brain (MGB) axis ...
Modulation of the gut microbiota with antibiotics or probiotic supplementation
may create new preventive and therapeutic options in AD. Accumulating evidences
affirm that research on MGB involvement in AD is necessary for new treatment
targets and therapies for AD"
-
Gut
microbes: a key to normal sleep - Science Daily, 11/30/20 -
"The researchers gave a group of mice a powerful
cocktail of antibiotics for four weeks, which depleted them of intestinal
microorganisms. Then, they compared intestinal contents between these mice and
control mice who had the same diet. Digestion breaks food down into bits and
pieces called metabolites. The research team found significant differences
between metabolites in the microbiota-depleted mice and the control mice. As
Professor Yanagisawa explains, "we found more than 200 metabolite differences
between mouse groups. About 60 normal metabolites were missing in the microbiota-depleted
mice, and the others differed in the amount, some more and some less than in the
control mice." ... the biological pathways most affected by the antibiotic
treatment were those involved in making neurotransmitters, the molecules that
cells in the brain use to communicate with each other. For example, the
tryptophan-serotonin pathway was almost totally shut down; the microbiota-depleted
mice had more tryptophan than controls, but almost zero serotonin. This shows
that without important gut microbes, the mice could not make any serotonin from
the tryptophan they were eating. The team also found that the mice were
deficient in vitamin B6 metabolites, which accelerate production of the
neurotransmitters serotonin and dopamine."
-
A Probiotic Lactobacillus
gasseri Alleviates Escherichia coli-Induced Cognitive Impairment and Depression
in Mice by Regulating IL-1β Expression and Gut Microbiota - Nutrients 2020
Nov 10 - "Excessive expression of interleukin (IL)-1β in
the brain causes depression and cognitive dysfunction. Herein, we investigated
the effect of Lactobacillus gasseri NK109, which suppressed IL-1β expression in
activated macrophages, on Escherichia coli K1-induced cognitive impairment and
depression in mice. Germ-free and specific pathogen-free mice with
neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated
K1-induced cognition-impaired and depressive behaviors, decreased the expression
of IL-1β and populations of NF-κB+/Iba1+ and IL-1R+ cells, and increased the
K1-suppressed population of BDNF+/NeuN+ cells in the hippocampus. However, its
effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated
K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed,
alleviated cognitive impairment and depression. In conclusion, NK109 alleviated
neuropsychiatric disorders and colitis by modulating IL-1β expression, gut
microbiota, and vagus nerve-mediated gut-brain signaling" -
See
probiotic supplements at Amazon.com
and
iHerb.
-
The Role of the Gut
Microbiota in Coronary Heart Disease - Curr Atheroscler Rep 2020 Oct 16 -
"A consensus has been reached that differences exist in
the gut microbiotas of patients with coronary heart disease. Studies have shown
that the gut microbiota is associated with obesity, diabetes, dyslipidemia, and
hypertension, which are risk factors for coronary heart disease. The gut
microbiota is involved in mediating basic metabolic processes, such as
cholesterol metabolism, uric acid metabolism, oxidative stress, and inflammatory
reactions, through its metabolites, which can induce the development of
atherosclerosis and coronary heart disease. Interfering with the composition of
gut microbiota, supplementing probiotics, and fecal donation are active areas of
research to potentially prevent and treat coronary heart disease. Gut microbiota
are causally associated with coronary heart disease. We analyzed the gut
microbiota's effects on risk factors for coronary heart disease and studied the
effects of gut microbiota metabolites on coronary heart disease. Gut microbiota
is a potential target for preventing and treating coronary heart disease."
- See probiotic supplements at Amazon.com
and
iHerb.
-
Non-Viable Lactobacillus
johnsonii JNU3402 Protects against Diet-Induced Obesity - Foods, 19 Oct 20 -
"In this study, the role of non-viable Lactobacillus
johnsonii JNU3402 (NV-LJ3402) in diet-induced obesity was investigated in mice
fed a high-fat diet (HFD). To determine whether NV-LJ3402 exhibits a protective
effect against diet-induced obesity, 7-week-old male C57BL/6J mice were fed a
normal diet, an HFD, or an HFD with NV-LJ3402 for 14 weeks. NV-LJ3402
administration was associated with a significant reduction in body weight gain
and in liver, epididymal, and inguinal white adipose tissue (WAT) and brown
adipose tissue weight in HFD-fed mice. Concomitantly, NV-LJ3402 administration
to HFD-fed mice also decreased the triglyceride levels in the plasma and
metabolic tissues and slightly improved insulin resistance. Furthermore,
NV-LJ3402 enhanced gene programming for energy dissipation in the WATs of
HFD-fed mice as well as in 3T3-L1 adipocytes with increased peroxisome
proliferator-activated receptor-γ (PPARγ) transcriptional activity, suggesting
that the PPARγ pathway plays a key role in mediating the anti-obesity effect of
NV-LJ3402 in HFD-fed mice. Furthermore, NV-LJ3402 administration in HFD-fed mice
enhanced mitochondrial levels and function in WATs and also increased the body
temperature upon cold exposure. Together, these results suggest that NV-LJ3402
could be safely used to develop dairy products that ameliorate diet-induced
obesity and hyperlipidemia" - [Nutra
USA] - See Lactobacillus johnsonii at
Amazon.com.
-
Effects of a Psychobiotic Supplement on Serum Brain-derived Neurotrophic Factor
Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical
Trial - J Neurogastroenterol Motil 2020 Sep 30 - "Psychobiotics
are probiotics or prebiotics that, upon ingestion in adequate amounts, yield
positive influence on mental health via microbiota-gut-brain axis regulation to
modulate the circulating cytokines, chemokines, neurotransmitters, or
neurotrophins levels. We have recently shown that a psychobiotic combination
(Lactobacillus helveticus R0052 and Bifidobacterium longum R0175; CEREBIOME)
significantly improved depression symptoms in patients with depression. Recent
animal data suggest the influence of the gut microbiota on brain-derived
neurotrophic factor (BDNF), which was shown to correlate with antidepressant
response in depressive patients. Therefore, we conducted this exploratory post
hoc analysis of BDNF levels to clarify the mechanism of action of this
psychobiotic in our cohort ... We compared serum BDNF levels from participants
at baseline and endpoint, and assessed the Pearson correlation between
depression severity and BDNF levels for each intervention ... We found that
post-intervention BDNF levels were significantly different between groups (P <
0.001). Furthermore, BDNF levels increased significantly in the probiotic group
compared to both the prebiotic (P < 0.001) and placebo" - [Nutra
USA] - See probiotic supplements at Amazon.com
and
iHerb and prebiotic supplements at
Amazon.com and
prebiotic supplements at iHerb.
-
Effects of Probiotic Strains
on Disease Activity and Enteric Permeability in Psoriatic Arthritis-A Pilot
Open-Label Study - Nutrients 2020 Aug 5 - "enrolled 10 PsA patients with low
to medium disease activity who received probiotics for 12 weeks ... All patients
showed increased levels of the enteric permeability marker zonulin which
correlated with the frequency of peripheral Th17 cells. Calprotectin, a marker
for intestinal inflammation was elevated in 6 out of 10 patients. Probiotic
intake resulted in a reduction of disease activity and gut permeability. These
effects, however, were not sustained beyond termination of probiotic intake. (4)
Conclusions: PsA patients suffer from enhanced enteric permeability and
inflammation. Probiotics may ameliorate disease activity in PsA by targeting
these alterations"
-
Antidepressant-like effects
of Lactobacillus plantarum DP189 in a corticosterone-induced rat model of
chronic stress - Behav Brain Res 2020 Aug 6 -
"Probiotic antidepressant effects demonstrated previously in clinical studies
and animal models act via unknown mechanism ... Behaviorally, DP189 treatment
improved memory and spatial learning and reduced anhedonia, as measured using
Morris water maze and sucrose preference tests, respectively.
Histopathologically, DP189 treatment ameliorated hippocampal pathological
changes and dramatically reduced TUNEL-positive cell numbers. Biochemically,
DP189 decreased serum IL-1β and TNF-α levels, decreased hippocampal mitogen-activated
protein kinase kinase 7 and c-Jun N-terminal kinase 2 levels, down-regulated
pro-apoptosis protein Bax immunocontent and up-regulated anti-apoptosis protein
Bcl-2 immunocontent. Collectively, these results suggest that DP189 treatment
may prevent and/or alleviate depression-like behaviors and hippocampal neural
injury induced by CORT"
-
Probiotic Bifidobacterium
breve prevents DOCA-salt hypertension - FASEB J 2020 Aug 11 -
"Many probiotics that affect gut microbial ecology have
been shown to produce beneficial effects on renin-angiotensin-dependent rodent
models and human hypertension. We hypothesized that Bifidobacterium breve
CECT7263 (BFM) would attenuate hypertension in deoxycorticosterone acetate
(DOCA)-salt rats, a renin-independent model of hypertension. Rats were randomly
divided into five groups: control, DOCA-salt, treated DOCA-salt-BFM, treated
DOCA-salt-butyrate, and treated DOCA-salt-acetate, for 5 weeks. BFM prevented
the increase in systolic blood pressure, cardiac weight, and renal damage
induced by DOCA-salt. BFM increased acetate-producing bacterial population and
gut acetate levels, improved colonic integrity, normalized endotoxemia, plasma
trimethylamine (TMA) levels, and restored the Th17 and Treg content in
mesenteric lymph nodes and aorta. Furthermore, BFM improved nitric
oxide-dependent vasorelaxation induced by acetylcholine in aortic rings and
reduced NADPH oxidase activity in DOCA-salt animals. These protective effects
were mimicked by acetate, but not by butyrate supplementation. These data
demonstrate that BFM induces changes in gut microbiota linked with attenuation
of endothelial dysfunction and increase in blood pressure in this low-renin form
of hypertension. These beneficial effects seem to be mediated by increased
acetate and reduced TMA production by gut microbiota, thus, improving gut
integrity and restoring Th17/Tregs polarization and endotoxemia"
-
Lactobacillus plantarum PS128
Improves Physiological Adaptation and Performance in Triathletes through Gut
Microbiota Modulation - Nutrients 2020, 12(8), 2315 -
"Probiotics, prebiotics, and synbiotics have been
reported to have health-promoting activities (e.g., immunoregulation and cancer
prevention) ... In our previous study, we found that Lactobacillus plantarum
PS128 could ameliorate inflammation and oxidative stress, with improved exercise
performance ... The triathletes were assigned to two groups: an L. plantarum 128
supplement group (LG, 3 × 1010 colony-forming units (CFU)/day) and a placebo
group (PG). Both groups continued with their regular exercise training for the
next 4 weeks. The endurance performance, body composition, biochemistries, blood
cells, microbiota, and associated metabolites were further investigated. PS128
significantly increased the athletes’ endurance, by about 130% as compared to
the PG group, but there was no significant difference in maximal oxygen
consumption (VO2max) and composition between groups" - [Nutra
USA] - See probiotics at Amazon.com
and
iHerb, prebiotics at Amazon.com and
iHerb, and
synbiotics at Amazon.com and
iHerb.
-
How
good gut bacteria help reduce the risk for heart disease - Science Daily,
7/8/20 - "Eubacterium limosum ... The chemical
linked to the clogged arteries that characterize atherosclerosis is called
trimethylamine, or TMA. It is produced during metabolism when some intestinal
microbes -- generally the bacteria considered unhelpful to humans -- interact
with certain nutrients from food. Among those nutrients is L-carnitine, a
chemical compound found in meat and fish that is also used as a nutritional
supplement to improve recovery after exercise ... Up until now, the only known
gut microbial reactions with L-carnitine involved converting it into its bad
form. We've discovered that a bacterium known to be beneficial could remove a
methyl group and send the resulting product down another pathway without making
any other harmful compounds in the process ... In these interactions,
L-carnitine functions as a growth substrate -- a compound consumed so the
organism can live and grow, and also a target for enzyme activity. In the study,
the researchers fed E. limosum cultures an assortment of potential substrates,
including L-carnitine. Only when offered L-carnitine did the microbe synthesize
the MtcB protein specifically to lop off L-carnitine's methyl group -- in
essence, MtcB is part of the bacteria's natural way to consume the nutrient"
-
Probiotics alone or combined with prebiotics may help ease depression -
Science Daily, 7/6/20 - "The studies varied
considerably in their design, methods used, and clinical considerations, but all
of them concluded that probiotic supplements either alone or in combination with
prebiotics may be linked to measurable reductions in depression ... And every
study showed a significant fall or improvement in anxiety symptoms and/or
clinically relevant changes in biochemical measures of anxiety and/or depression
with probiotic or combined pre-probiotic use ... Probiotics may help reduce the
production of inflammatory chemicals, such as cytokines, as is the case in
inflammatory bowel disease, suggest the researchers. Or they may help direct the
action of tryptophan, a chemical thought to be important in the gut-brain axis
in psychiatric disorders" - [Nutra
USA]
-
Targeting the Intestinal
Microbiota to Prevent Type 2 Diabetes and Enhance the Effect of Metformin on
Glycaemia: A Randomised Controlled Pilot Study - Nutrients 2020 Jul 9 -
"Probiotics may act as an adjunctive to metformin by
increasing the production of butyrate, which may consequently enhance glucose
management"
-
Effects of Long-Term
Administration of Multi-Strain Probiotic on Circulating Levels of BDNF, NGF,
IL-6 and Mental Health in Patients With Multiple Sclerosis: A Randomized,
Double-Blind, Placebo-Controlled Trial - Nutr Neurosci 2020 Jun 5;1-12 -
"Patients were randomized into intervention and control
groups to receive 2 multi-strain probiotic capsules or placebo, daily for six
months ... From baseline to 6 months, probiotic supplementation resulted in a
significant increase in BDNF and a significant reduction in the IL-6 levels (P <
0.001). Our findings revealed that probiotic supplementation compared to placebo
caused a significant improvement in the general health questionnaire-28 (GHQ-28)
(-5.31 ± 4.62 vs. -1.81 ± 4.23; P = 0.002), Beck Depression Inventory-II
(BDI-II) (-4.81 ± 0.79 vs. -1.90 ± 0.96; P = 0.001), Fatigue Severity Scale
(FSS) (-3.81 ± 6.56 vs. 0.24 ± 5.44; P = 0.007) and Pain Rating Index (PRI) ...
Overall, six months of probiotic supplementation resulted in greater improvement
in mental health parameters"
-
Very Long-Term Treatment
With a Lactobacillus Probiotic Preparation, Lactobacillus casei Strain Shirota,
Suppresses Weight Loss in the Elderly - Nutrients 2020 May 29 -
"To reveal the potential benefit of long-term lactic
acid, the effects of bacteria-based probiotics for health maintenance were
examined. This observational study included the participants from a previous
clinical study designed to evaluate the effects of wheat bran biscuits or
Lactobacillus preparation, 3 g/day biolactis powder (BLP), in preventing
colorectal tumor. The participants were provided an option to continue treatment
with BLP on an outpatient basis after completion of the study. The 380 patients
who completed the study were contacted and asked to participate in the present
study and those who consented were surveyed for cancer incidence, treatment
compliance, lifestyle, weight, and other variables ... The mean follow-up period
was 7913 days (21.7 years). Cancer developed in 24 of 128 (18.8%) patients in
the BLP extension group and 24 of 109 (22.0%) patients in the non-BLP extension
group (risk ratio 0.88 [95% confidence interval 0.53-1.47]). Although no
significant difference was observed, the cumulative cancer incidence rose at a
slightly lower rate in the BLP extension group. Both groups showed a significant
weight decrease over the course of 20 years, although the decrease in the BLP
extension group was only 1.4 kg, compared with 2.8 kg in the non-BLP extension
group. Very long-term treatment with a Lactobacillus probiotic preparation
suppressed weight loss in the elderly."
-
In vitro
inhibitory effect of two commercial probiotics on chromogenic actinomycetes
- Eur Arch Paediatr Dent 2020 Feb 7 - "Streptococcus
salivarius M18 and Lactobacillus reuteri were tested against Aggregatibacter
actinomycetemcomitans and Actinomyces naeslundiiusing their cell-free
fermentative broth in a planktonic growth inhibition test." - [Nutra
USA]
-
Does Streptococcus
Salivarius Strain M18 Assumption Make Black Stains Disappear in Children? -
Oral Health Prev Dent 2020;18(2):161-164 - "This
randomised controlled study evaluated the effectiveness of an oral probiotic,
Streptococcus salivarius M18 (SsM18), in children with black stains (BSs) in
order to counteract their reformation ... BSs formation in children could be
prevented by administering S. salivarius M18" - [Nutra
USA]
-
A randomised
controlled study shows supplementation of overweight and obese adults with
lactobacilli and bifidobacteria reduces bodyweight and improves well-being -
Sci Rep. 2020 Mar 6 - "220 Bulgarian participants (30 to
65 years old) with BMI 25–34.9 kg/m2 received Lab4P
probiotic (50 billion/day) or a matched placebo for 6 months. Participants
maintained their normal diet and lifestyle ... Significant between group
decreases in body weight (1.3 kg,
p < 0.0001), BMI (0.045 kg/m2, p < 0.0001), WC (0.94 cm, p < 0.0001) and WtHR
(0.006, p < 0.0001) were in favour of the probiotic. Stratification identified
greater body weight reductions in overweight subjects (1.88%, p < 0.0001) and in
females (1.62%, p = 0.0005). Greatest weight losses were among probiotic
hypercholesterolaemic participants (-2.5%, p < 0.0001) alongside a significant
between group reduction in small dense LDL-cholesterol (0.2 mmol/L, p = 0.0241).
Improvements in QoL and the incidence rate ratio of URTI (0.60, p < 0.0001) were
recorded for the probiotic group. No adverse events were recorded. Six months
supplementation with Lab4P probiotic resulted in significant weight reduction
and improved small dense low-density lipoprotein-cholesterol (sdLDL-C) profiles,
QoL and URTI incidence outcomes in overweight/obese individuals" - [Nutra
USA]
-
Lactobacillus acidophilus
DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and
Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial -
Nutrients. 2020 Jan 30 - "The primary outcome was the
change in Abdominal Pain Severity - Numeric Rating Scale (APS-NRS). Over the
intervention period, APS-NRS was significantly improved in both probiotic groups
vs. placebo in absolute terms (DDS-1: -2.59 ± 2.07, p = 0.001; UABla-12: -1.56 ±
1.83, p = 0.001) and in percentage of significant responders (DDS-1: 52.3%, p <
0.001); UABla-12 (28.2%, p = 0.031). Significant amelioration vs. placebo was
observed in IBS Symptom Severity Scale (IBS-SSS) scores for L. acidophilus DDS-1
(-133.4 ± 95.19, p < 0.001) and B. lactis UABla-12 (-104.5 ± 96.08, p < 0.001)
groups, including sub-scores related to abdominal pain, abdominal distension,
bowel habits and quality of life. Additionally, a significant normalization was
observed in stool consistency in both probiotic groups over time and as compared
to placebo. In conclusion, L. acidophilus DDS-1 and B. lactis UABla-12 improved
abdominal pain and symptom severity scores with a corresponding normalization of
bowel habits in adults with IBS" - [Nutra
USA]
-
Lactobacillus salivarius
Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise
Performance and Decreasing Fatigue? - Microorganisms 2020, 8(4), 545 -
"Probiotics are increasingly being used as a nutritional
supplement by athletes to improve exercise performance and reduce post-exercise
fatigue. Lactobacillus salivarius is a natural flora in the gastrointestinal
tract of humans and animals. Lactobacillus salivarius subspecies salicinius
(SA-03) is an isolate from the 2008 Olympic women’s 48 kg weightlifting gold
medalist’s gut microbiota. In this study, we investigated its beneficial effects
on physical fitness. Male ICR mice were divided into four groups (n = 10 per
group) and orally administered with SA-03 for 4 weeks at 0, 2.05 × 109, 4.10 ×
109, or 1.03 × 1010 CFU/kg/day. Results showed that 4 weeks of SA-03
supplementation significantly improved muscle strength and endurance
performance, increased hepatic and muscular glycogen storage, and decreased
lactate, blood urea nitrogen (BUN), ammonia, and creatine kinase (CK) levels
after exercise. These observations suggest that SA-03 could be used as a
nutritional supplement to enhance exercise performance and reduce" - [Nutra
USA] - See
Lactobacillus salivarius at
Amazon.com.
-
The Role of Probiotics in
Colorectal Cancer Management - Evid Based Complement Alternat Med. 2020 Feb
14 - "The recent scientific evidence suggested that
probiotic supplementation protects the CRC patients from treatment-associated
adverse effects. The manuscript summarizes the influence of probiotic
supplementation on the health status of CRC patients and discusses the possible
mechanism behind the protective effect of probiotics against CRC. The literature
survey revealed that beneficial impact of probiotic supplementation depends on
several factors such as strain, dosage, duration of the intervention, host
physiology, and other food supplements. The probiotic intervention improves the
microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove
carcinogens, and improves the intestinal permeability, tight junction function,
and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit
anti-CRC activities; it is necessary to screen the potent strain for the
development of a probiotic-based therapeutic agent to control or prevent the
incidence of CRC."
-
International Society of Sports Nutrition Position Stand: Probiotics - J
Inter Society of Sports Nutri, 19 Dec 2019 - "Given all
the known benefits and favorable safety profile of probiotic supplementation
reported in the scientific and medical literature, probiotics are commonly used
to optimize the health of athletes. Regular consumption of specific probiotic
strains may assist with immune function and may reduce the number of sick days
an athlete experiences when training or during competition. Certain probiotic
strains may reduce the severity of respiratory infection and GI disturbance when
they occur. Probiotic benefits are strain specific and dose dependent, and
include improved gut-barrier function, nutrient absorption, recovery and
performance in athletes. When choosing a probiotic product, athletes are
encouraged to use clinically researched strains with validated benefits,
matching the athletes desired health benefit. Studies investigating the effects
of probiotics in athletic populations and on sports performance are limited and
warrant further investigation" - [Nutra
USA] - See probiotic supplements at Amazon.com.
-
Lactobacillus rhamnosus
Granules Dose-Dependently Balance Intestinal Microbiome Disorders and Ameliorate
Chronic Alcohol-Induced Liver Injury - J Med Food. 2019 Nov 20 -
"Previously, we have demonstrated that Lactobacillus
rhamnosus GG (LGG) can prevent alcoholic liver injury ... We found LGG granules
dose-dependently protected against chronic alcoholic liver disease. When alcohol
was consumed for 8 weeks with LGG treatment during the last 2 weeks, we
demonstrated that the dose dependence of LGG granules can improve
alcohol-induced liver injury through decreasing the levels of lipopolysaccharide
and tumor necrosis factor-α in serum and prevent liver steatosis by suppressing
triglyceride, free fatty acid, and malondialdehyde production in liver. Alcohol
feeding caused a decline in the number of both Lactobacillus and Bifidobacterium,
with a proportional increase in the number of Clostridium perfringens in ileum,
and expansion of the Gram-negative bacteria Proteobacteria, Campylobacterales,
and Helicobacter in cecum. However, LGG granule treatment restored the content
of these microorganisms. In conclusion, LGG granule supplementation can improve
the intestinal microbiota, reduce the number of gram-negative bacteria, and
ameliorate alcoholic liver injury" - [Nutra
USA]
-
Cell-free extracts of
Lactobacillus acidophilus and Lactobacillus delbrueckii display
antiproliferative and antioxidant activities against HT-29 cell line - Nutr
Cancer. 2019 Nov 11:1-10 - "cell viability was significantly reduced to
42.2 ± 0.01% and 19.40 ± 0.01% by 5 and 8 mg ml-1 of L. acidophilus and L. delbrueckii extracts, respectively. Apoptosis induction was shown with both
bacterial extracts. Caspase-9 and caspase-3 overexpression as well as Bax/Bcl-2
ratio increase revealed the ability of both probiotics to induce intrinsic
pathway-dependent apoptosis. The extrinsic pathway was also activated by L.
acidophilus. At the concentration of 198 µg ml-1, L. acidophilus and L.
delbrueckii had a DPPH scavenging activity of 59.37 ± 3.97% and 71.19 ± 3.64%,
respectively. Taken together, these findings provide evidence for
antiproliferative, proapoptotic, and antioxidant effects driven by these
probiotic lactic acid bacteria (LAB) strains"
-
Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine
bone loss in postmenopausal women: a randomised, double-blind,
placebo-controlled, multicentre trial - Lancet Nov 2019 -
"Lactobacillus treatment reduced the LS-BMD loss
compared with placebo (mean difference 0·71%, 95% CI 0·06 to 1·35). The LS-BMD
loss was significant in the placebo group (–0·72%, −1·22 to −0·22), whereas no
bone loss was observed in the Lactobacillus-treated group (–0·01%, −0·50 to
0·48). The adverse events were similar between the two groups" - [Nutra
USA]
-
The probiotic
Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat
diet-treated rats - Nutr Metab Cardiovasc Dis. 2019 Aug 14 -
"High-fat (HF)
diet consumption has been associated with gut dysbiosis and increased risk of
dyslipidemia, type 2 diabetes mellitus and hypertension. Probiotic
administration has been suggested as a safe therapeutic strategy for the
treatment of cardiometabolic disorders. This study was designed to assess the
effects of probiotic Lactobacillus (L.) fermentum 296, a fruit-derived bacteria
strain, against cardiometabolic disorders induced by HF diet ... The
administration of L. fermentum 296 for 4 weeks recovered fecal Lactobacillus sp.
counts and alleviated hyperlipidemia, sympathetic hyperactivity, and reduced
systolic blood pressure in HF rats without affecting baroreflex sensibility ...
Our results suggest the ability of L. fermentum 296 improve biochemical and
cardiovascular parameters altered in cardiometabolic disorders"
-
Can Bugs be Drugs? The
Potential of Probiotics and Prebiotics as Treatment for Non-alcoholic Fatty
Liver Disease - Medscape, 10/16/19 - "The most
promising strategies thus far developed to alter the microbiome in NAFLD-NASH
are probiotics and prebiotics. However, pre- and probiotic treatment of
NAFLD-NASH is relatively new and still under development. Actual understanding
of the involved mechanisms is lacking and changes in the intestinal microbiota
composition after treatment are rarely measured. Furthermore, large clinical
trials with comparative endpoints are unavailable. Personalised treatment based
on metagenomics gut microbiota analysis will probably be part of the future
diagnosis and treatment of NAFLD-NASH"
-
Hypnotic Effects of
Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice -
Nutrients. 2019 Oct 9;11(10) - "The bidirectional communication between the
gastrointestinal tract and the central nervous system appears to be functionally
linked to the intestinal microbiome, namely the microbiome-gut-brain axis
(MGBA). Probiotics with health benefits on psychiatric or neurological illnesses
are generally called psychobiotics, and some of them may also be able to improve
sleep by targeting the MGBA. This study aimed to investigate the effects of a
psychobiotic strain, Lactobacillus fermentum PS150TM (PS150TM), on sleep
improvement by using a pentobarbital-induced sleep mouse model. Compared with
the vehicle control group, the oral administration of PS150TM, but not the other
L. fermentum strains, significantly decreased the sleep latency and increased
the sleep duration of mice, suggesting strain-specific sleep-improving effects
of PS150TM. Moreover, the ingestion of diphenhydramine, an antihistamine used to
treat insomnia, as a drug control group, only increased the sleep duration of
mice. We also found that the sleep-improving effects of PS150TM are time- and
dose-dependent. Furthermore, the oral administration of PS150TM could attenuate
a caffeine-induced sleep disturbance in mice, and PS150TM appeared to increase
the expression of the gene encoding the adenosine 1 receptor in the hypothalamus
of mice, as assessed by quantitative real-time polymerase chain reaction. Taken
together, our results present a potential application of PS150TM as a dietary
supplement for sleep improvement"
-
The neuroactive potential
of the human gut microbiota in quality of life and depression - Nat
Microbiol. 2019 Apr;4(4):623-632 - "The relationship
between gut microbial metabolism and mental health is one of the most intriguing
and controversial topics in microbiome research ... Butyrate-producing
Faecalibacterium and Coprococcus bacteria were consistently associated with
higher quality of life indicators. Together with Dialister, Coprococcus spp.
were also depleted in depression, even after correcting for the confounding
effects of antidepressants. Using a module-based analytical framework, we
assembled a catalogue of neuroactive potential of sequenced gut prokaryotes.
Gut-brain module analysis of faecal metagenomes identified the microbial
synthesis potential of the dopamine metabolite 3,4-dihydroxyphenylacetic acid as
correlating positively with mental quality of life and indicated a potential
role of microbial γ-aminobutyric acid production in depression. Our results
provide population-scale evidence for microbiome links to mental health, while
emphasizing confounder importance" - [Full Text] - [Nutra USA] - See
probiotic supplements at Amazon.com.
-
The gut microbiota
influences skeletal muscle mass and function in mice - Sci Transl Med. 2019
Jul 24;11(502) - "We compared the skeletal muscle of
germ-free mice that lacked a gut microbiota to the skeletal muscle of
pathogen-free mice that had a gut microbiota. Compared to pathogen-free mouse
skeletal muscle, germ-free mouse skeletal muscle showed atrophy, decreased
expression of insulin-like growth factor 1, and reduced transcription of genes
associated with skeletal muscle growth and mitochondrial function. Nuclear
magnetic resonance spectrometry analysis of skeletal muscle, liver, and serum
from germ-free mice revealed multiple changes in the amounts of amino acids,
including glycine and alanine, compared to pathogen-free mice. Germ-free mice
also showed reduced serum choline, the precursor of acetylcholine, the key
neurotransmitter that signals between muscle and nerve at neuromuscular
junctions. Reduced expression of genes encoding Rapsyn and Lrp4, two proteins
important for neuromuscular junction assembly and function, was also observed in
skeletal muscle from germ-free mice compared to pathogen-free mice.
Transplanting the gut microbiota from pathogen-free mice into germ-free mice
resulted in an increase in skeletal muscle mass, a reduction in muscle atrophy
markers, improved oxidative metabolic capacity of the muscle, and elevated
expression of the neuromuscular junction assembly genes Rapsyn and Lrp4 Treating
germ-free mice with short-chain fatty acids (microbial metabolites) partly
reversed skeletal muscle impairments" - [Nutra
USA]
-
Probiotics Reduce Health Care Cost and Societal Impact of Flu-Like Respiratory
Tract Infections in the USA: An Economic Modeling Study - Front. Pharmacol.,
28 August 2019 - "The analysis showed that generalized
probiotic intake in the US population for 2017–2018 would have allowed cost
savings for the health care payer of 4.6 million USD based on the YHEC scenario
and 373 million USD for the Cochrane scenario, by averting 19 million and 54.5
million RTI sick days, respectively, compared to no probiotics" - [Nutra
USA]
-
Probiotic treatment
improves the impaired spatial cognitive performance and restores synaptic
plasticity in an animal model of Alzheimer's disease - Behav Brain Res.
2019 Aug 28 - "Studies demonstrate that damage to gut
microbiota is associated with some brain disorders including neurodegenerative
diseases such as Alzheimer's disease (AD). Accordingly, supporting gut
microbiota has been considered as a possible strategy for AD treatment ... Two
groups of Alzheimeric animals were treated by either vehicle (Alz) or probiotics
(Pro + Alz) ... long-term potentiation (LTP) ... We found that while the Alz
animals displayed a weak spatial performance, probiotic treatment improved the
maze navigation. Whereas basic synaptic transmission remained unchanged in the
Alz rats, LTP was suppressed in this group. Probiotic treatment significantly
restored LTP in the Pro + Alz group and further enhanced it in the Pro + Con
rats. The intervention also showed a favorable effect on balance of the
anti-oxidant/oxidant biomarkers in the Pro + Alz rats. This study provides the
first proof on positive effect of probiotics on synaptic plasticity in an animal
model of AD"
-
Probiotics for the
Treatment of Type 2 Diabetes: A Review of Randomized Controlled Trials -
Diabetes Metab Res Rev. 2019 Aug 29 - "Based on the
evidence reviewed, multi-strain probiotics that contain seven million to 100
billion colony forming units of Lactobacillus acidophilus, Streptococcus
thermophilus, Lactobacillus bulgaricus, and/or Bifidobacterium lactis
administered for six to twelve weeks may be efficacious for improving glycemic
control in adults with T2DM"
-
Lactobacillus reuteri
V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal
Microbiome in Adults with Metabolic Syndrome: The PROSIR Study - Nutrients.
2019 Jul 31;11(8) - "Previous studies have reported that
probiotics may improve clinical and inflammatory parameters in patients with
obesity and metabolic syndrome (MetS). Lactobacillus (L.) reuteri V3401 has
shown promising results on the components of MetS in animal studies ... 53 adult
patients newly diagnosed with MetS. Patients were block randomly allocated by
body mass index (BMI) and sex to receive a capsule containing either the
probiotic L. reuteri V3401 (5 × 109 colony-forming units) or a placebo once
daily for 12 weeks ... interleukin-6 (IL-6) and soluble vascular cell adhesion
molecule 1 (sVCAM-1) diminished by effect of the treatment with L. reuteri
V3401. Analysis of the gastrointestinal microbiome revealed a rise in the
proportion of Verrucomicrobia"
-
Altered microbiome
composition in individuals with fibromyalgia - Pain. 2019 Jun 18 -
"When comparing FM patients to unrelated controls using
differential abundance analysis, significant differences were revealed in
several bacterial taxa. Variance in the composition of the microbiomes was
explained by FM-related variables more than by any other innate or environmental
variable and correlated with clinical indices of FM. In line with observed
alteration in butyrate metabolising species, targeted serum metabolite analysis
verified differences in the serum levels of butyrate and propionate in FM
patients. Using machine learning algorithms, the microbiome composition alone
allowed for the classification of patients and controls (ROC AUC 87.8%)"
- [Nutra
USA]
-
The combination of sport
and sport-specific diet is associated with characteristics of gut microbiota: an
observational study - J Int Soc Sports Nutr. 2019 May 3 -
"Results suggest
that high-protein diets may have a negative impact on gut microbiota diversity
for athletes, while athletes in resistance sports that carry out the high
protein low carbohydrates diet demonstrate a decrease in short chain fatty
acid-producing commensal bacteria" - [Nutra
USA]
-
Lactobacillus acidophilus
Exerts Neuroprotective Effects in Mice with Traumatic Brain Injury - J Nutr.
2019 Jun 7 - "Our results demonstrate that LA exerts
neuroprotective effects that may be associated with gut microbiota remodeling in
TBI mice" - See
probiotic products at Amazon.com.
-
Lactobacillus plantarum
DR7 alleviates stress and anxiety in adults: a randomised, double-blind,
placebo-controlled study - Benef Microbes. 2019 Apr 19 -
"One hundred and eleven (n=111; DR7 n=56, placebo n=55)
stressed adults were recruited based on moderate stress levels using the PSS-10
questionnaire. The consumption of DR7 (1×109 cfu/day) for 12 weeks reduced
symptoms of stress (P=0.024), anxiety (P=0.001), and total psychological scores
(P=0.022) as early as 8 weeks among stressed adults compared to the placebo
group as assessed by the DASS-42 questionnaire. Plasma cortisol level was
reduced among DR7 subjects as compared to the placebo, accompanied by reduced
plasma pro-inflammatory cytokines, such as interferon-γ and transforming growth
factor-α and increased plasma anti-inflammatory cytokines, such as interleukin
10 (P<0.05). DR7 better improved cognitive and memory functions in normal adults
(>30 years old), such as basic attention, emotional cognition, and associate
learning (P<0.05), as compared to the placebo and young adults (<30 years old).
The administration of DR7 enhanced the serotonin pathway, as observed by lowered
expressions of plasma dopamine β-hydroxylase (DBH), tyrosine hydroxylase (TH),
indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by
increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine
receptor-6, while stabilising the dopamine pathway as observed via stabilised
expressions of TH and DBH over 12 weeks as compared to the placebo" - [Nutra
USA]
-
Effect of Cell
Concentration on the Persistence in the Human Intestine of Four Probiotic
Strains Administered through a Multispecies Formulation - Nutrients 2019,
11(2), 285 - "The overall persistence of the probiotic strains was significantly
higher for the 70 billion formulation than for the 7 billion formulation.
Furthermore, probiotic strains were detected earlier and for longer for the 70
billion formulation compared to those for the 7 billion formulation. All
probiotic strains were recovered alive from the 70 billion preparation, whereas
recovery was not possible in a few fecal samples upon administration of the 7
billion preparation. In addition, the overall number of viable probiotic cells
recovered on day 14 (i.e., the last day of consumption) was significantly higher
for the 70 billion formulation than that for the 7 billion formulation. Finally,
we found that the viability of the probiotic cells was stable over the course of
the trial independent of volunteers’ handling, demonstrating good manufacturing
of the product. In conclusion, this study demonstrated that strains belonging to
different taxa may coexist in the human gastrointestinal tract upon ingestion of
a multispecies probiotic formulation. Moreover, this study suggests that higher
doses of bacterial cells in probiotic formulations may permit a higher, earlier,
and longer recovery of the probiotics in the feces of healthy adults" - [Nutra
USA] - See
probiotic products at Amazon.com.The Effects of
Lactobacillus casei on Glycemic Response, Serum Sirtuin1 and Fetuin-A Levels in
Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial - ibj
2019, 23(1): 68-77 - "daily capsule containing 108 cfu of L. casei for eight
weeks ... Fasting blood sugar, insulin concentration, and insulin resistance
significantly decreased in probiotic group compared with placebo group (-28.32
[-50.23 to -6.41], 0.013; -3.12 [-5.90 to -0.35], 0.028; -32.31 [-55.09 to
-9.54], 0.007, respectively). Moreover, HbA1c reduced after intervention, but
the reduction was not significant (-0.45 [-0.96 to 0.05], 0.077). In comparison
with placebo, the L. casei supplementation significantly increased SIRT1 and
decreased fetuin-A levels at the end of the trial (0.52 [0.026 to 1.02], 0.040;
-17.56 [-32.54 to -2.58], 0.023, respectively)" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
Beneficial Effects of
Probiotic Consumption on the Immune System - Ann Nutr Metab. 2019 Jan
23;74(2):115-124 - "Once administered, oral probiotic
bacteria interact with the intestinal epithelial cells (IECs) or immune cells
associated with the lamina propria, through Toll-like receptors, and induce the
production of different cytokines or chemokines ... Specifically, probiotics
activate regulatory T cells that release IL-10. Interestingly, probiotics
reinforce the intestinal barrier by an increase of the mucins, the tight
junction proteins and the Goblet and Paneth cells. Another proposed mechanism of
probiotics is the modulation of intestinal microbiota by maintaining the balance
and suppressing the growth of potential pathogenic bacteria in the gut.
Furthermore, it has been demonstrated that long-term probiotics consumption does
not affect the intestinal homeostasis. The viability of probiotics is crucial in
the interaction with IECs and macrophages favoring, mainly, the innate immune
response ... In malnutrition models, such as undernourishment and obesity,
probiotic was able to increase the intestinal and systemic immune response.
Furthermore, probiotics contribute to recover the histology of both the
intestine and the thymus damaged in these conditions. Probiotic bacteria are
emerging as a safe and natural strategy for allergy prevention and treatment.
Different mechanisms such as the generation of cytokines from activated
pro-T-helper type 1, which favor the production of IgG instead of IgE, have been
proposed" - See
probiotic products at Amazon.com.
-
Probiotic Lactobacillus
reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and
Preventing Barrier Disruption - J Bone Miner Res. 2019 Jan 28 -
"Antibiotic treatment, commonly prescribed for bacterial
infections, depletes and subsequently causes long-term alterations in intestinal
microbiota composition. Knowing the importance of the microbiome in the
regulation of bone density, we investigated the effect of postantibiotic
treatment on gut and bone health ... A link between the microbiome composition
and bone density was demonstrated by supplementing the mice with probiotic
bacteria. Specifically, Lactobacillus reuteri, but not Lactobacillus rhamnosus
GG or nonpathogenic Escherichia coli, reduced the postantibiotic elevation of
the Firmicutes:Bacteroidetes ratio and prevented femoral and vertebral
trabecular bone loss. Consistent with causing bone loss, postantibiotic-induced
dysbiosis decreased osteoblast and increased osteoclast activities, changes that
were prevented by both L. reuteri and MDY. These data underscore the importance
of microbial dysbiosis in the regulation of intestinal permeability and bone
health, as well as identify L. reuteri and MDY as novel therapies for preventing
these adverse effects"
-
The effects of a
multispecies probiotic supplement on inflammatory markers and episodic and
chronic migraine characteristics: A randomized double-blind controlled trial
- Cephalalgia. 2019 Jan 8 - "Forty episodic and 39
chronic migraine patients who completed this randomized double-blind controlled
trial received two capsules of multispecies probiotic or placebo ... After a
10-week intervention, among episodic migraineurs the mean frequency of migraine
attacks significantly reduced in the probiotic group compare to the placebo
group (mean change: -2.64 vs. 0.06; respectively, p < 0.001). A significant
reduction was also evident in the migraine severity (mean decrease: -2.14 in the
probiotic group and 0.11 in the placebo group; p < 0.001). Episodic migraineurs
who received the probiotic also showed significant reduction in abortive drug
usage per week (mean change: -0.72; p < 0.001) compare to baseline, while there
was no significant changes within the placebo group. In chronic migraine
patients, after an 8-week intervention, the mean frequency of migraine attacks
significantly reduced in the probiotic compared to the placebo group (mean
change: -9.67 vs. -0.22; p ≤ 0.001). In contrast to the placebo, probiotic
supplementation significantly decreased the severity (mean changes: -2.69;
p ≤ 0.001), duration (mean changes: -0.59; p ≤ 0.034) of attacks and the number
of abortive drugs taken per day (mean changes: -1.02; p < 0.001), in chronic
migraine patients." - [Nutra
USA] - See
probiotic products at Amazon.com.
-
Effects of probiotic
supplements on the progression of chronic kidney disease: a meta-analysis -
Nephrology (Carlton). 2018 Dec 18 - "urea level was significantly reduced in
probiotics-administrated non-dialysis patients"
-
What Is a Blood Urea Nitrogen Test? - WebMD -
"The blood
urea nitrogen test, which is also called a BUN or serum BUN
test, measures how much of the waste product you have in
your blood. If your levels are off the normal range, this
could mean that either your kidneys or your liver may not be
working properly."
-
The intestinal microbiome
and its relevance for functionality in older persons - Curr Opin Clin Nutr
Metab Care. 2019 Jan;22 - "The intestinal microbiome composition represents a
possible determinant of functional performance in older people, and a promising
target for antiaging therapeutic interventions"
-
Gut microbiota in common
elderly diseases affecting activities of daily living - World J
Gastroenterol. 2018 Nov 14 - "Gut microbiota are
involved in the development or prevention of various diseases such as type 2
diabetes, fatty liver, and malignancy such as colorectal cancer, breast cancer
and hepatocellular carcinoma. Alzheimer's disease, osteoporosis, sarcopenia,
atherosclerotic stroke and cardiovascular disease are major diseases associated
with decreased activities of daily living (ADL), especially in elderly people.
Recent analyses have revealed the importance of gut microbiota in the control of
these diseases. The composition or diversity of these microbiota is different
between patients with these conditions and healthy controls, and administration
of probiotics or prebiotics has been shown effective in the treatment of these
diseases. Gut microbiota may affect distant organs through mechanisms that
include regulating the absorption of nutrients and/or the production of
microbial metabolites, regulating and interacting with the systemic immune
system, and translocating bacteria/bacterial products through disrupted mucosal
barriers. Thus, the gut microbiota may be important regulators in the
development of diseases that affect ADL" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
The Effects of Probiotic
Formulation Pretreatment (Lactobacillus helveticus R0052 and Bifidobacterium
longum R0175) on a Lipopolysaccharide Rat Model - J Am Coll Nutr. 2018 Oct
11:1-9 - "The role of gut microbiota in the pathogenesis of several
neurodegenerative disorders, including Alzheimer's disease (AD), via the
gut-brain axis has recently been demonstrated; hence, modification of the
intestinal microbiota composition by probiotic biotherapy could be a therapeutic
target for these conditions ... These results suggest that the management of gut
microbiota with this probiotic formulation could be a promising intervention to
improve neuroinflammation-associated disorders such as AD"
-
Effects of Turmeric and
Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind,
Randomized, Placebo-Controlled Pilot Study - J Evid Based Integr Med. 2018
Jan-Dec;23:2515690X18790725 - "Turmeric tablets with extract of piperine (Bioperine)
(n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3)
were provided to healthy human subjects and subsequent changes in the gut
microbiota were determined by 16S rDNA sequencing ... All participants'
microbiota displayed significant variation over time and individualized response
to treatment. Among the responsive participants, both turmeric and curcumin
altered the gut microbiota in a highly similar manner, suggesting that curcumin
may drive the majority of observed changes observed in turmeric-treated
subjects" - [Nitra
USA] - See
curcumin products at Amazon.com.
-
Effects of a 6-month
multi-strain probiotics supplementation in endotoxemic, inflammatory and
cardiometabolic status of T2DM patients: A randomized, double-blind,
placebo-controlled trial - Clin Nutr. 2018 Aug 17 - "Multi-strain
probiotics supplementation for 6 months caused a significant decrease in
circulating levels of endotoxin by almost 70% over 6 months, as well as glucose
(38%), insulin (38%), HOMA-IR (64%), triglycerides (48%), total cholesterol
(19%), total/HDL-cholesterol ratio (19%), TNF-α (67%), IL-6 (77%), CRP (53%),
resistin (53%), and a significant increase in adiponectin (72%) as compared with
baseline. Only HOMA-IR had a clinically significant reduction (-3.4, 64.2%) in
the probiotics group as compared to placebo group at all time points" -
[Nutra
USA]
-
Longevity extension
in Drosophila through gut-brain communication - Scientific Reportsvolume 8,
Article number: 8362 (2018), 30 May 2018 - "With age,
the body become less efficient at handling environmental stresses leading to a
myriad of physiological imbalances including elevated inflammation, oxidative
stress, metabolic dysregulation and mitochondrial damage. There will never be a
single therapeutic or dietary solution to manage the mounting chronic diseases
associated with aging; however, maintaining a healthy gut microbiota through the
use probiotic and prebiotic supplements can delay chronic disease onset and
promote longevity by simultaneously affecting each of the main triggers of
aging" - [Nutra
USA]
-
Effect of probiotic and
prebiotic vs placebo on psychological outcomes in patients with major depressive
disorder: A randomized clinical trial - Clin Nutr. 2018 Apr 24 -
"Beck
Depression Inventory (BDI) ... major depressive disorder (MDD) ... From baseline
to 8 weeks, probiotic supplementation resulted in a significant decrease in BDI
score (17.39-9.1) compared to the placebo (18.18-15.55) and prebiotic
(19.72-14.14) supplementation" - See See
probiotic products at Amazon.com.
-
Probiotics useful in the fight against Clostridium difficile infection -
Science Daily, 4/26/18 - "probiotics reduced the odds of
CDI by about two-thirds in both their non-adjusted and adjusted models
(adjusting for age, sex, hospitalization status, use of multiple antibiotics,
and exposure to high-risk antibiotics). Additionally, they found that compared
to no probiotics, multi-species probiotics were more beneficial than
single-species probiotics"
-
Effect of Lactobacillus
rhamnosus and Bifidobacterium lactis on gingival health, dental plaque, and
periodontopathogens in adolescents: a randomised placebo-controlled clinical
trial - Benef Microbes. 2018 Apr 10:1-10 -
"Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis BB-12 ... Both
groups received two probiotic-laced or placebo lozenges twice a day during a
four-week period ... Probiotic lozenges significantly reduced levels of A.
actinomycetemcomitans and F. nucleatum in saliva and plaque (P<0.05) and levels
of P. gingivalis in plaque (P<0.05), while no significant changes were found in
the control group. A significant reduction (P<0.001) was also noted in the total
salivary bacterial counts of the test group. The short-term daily consumption of
LGG and BB-12 probiotic lozenges improved the gingival health in adolescents and
decreased the microbial counts of A. actinomycetemcomitans, and P. gingivalis.
Hence probiotic supplements may serve as a simple adjunct to standard oral care
for promoting the oral health in adolescents" - [Nutra
USA]
-
Randomized, Double Blind and Placebo Controlled Study Using a Combination of Two
Probiotic Lactobacilli to Alleviate Symptoms and Frequency of Common Cold -
Food and Nutrition Sciences, 2013, 4, 13-20 - "Although
the number of episodes was similar in both groups, cold episodes in the active
group were significantly shorter than in the placebo group. The total sum scores
of cold symptoms were significantly lower in the active group as compared with
the placebo group, as well as in the intention-to-treat (ITT) as in the
per-protocol (PP) collectives (ITT: 75.2 ± 40.3 vs. 113.4 ± 66.3" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
Probiotic treatment
protects against the pro-depressant-like effect of high-fat diet in Flinders
Sensitive Line rats - Brain Behav Immun. 2017 Oct;65:33-42 -
"Major depressive disorder (MDD) is highly associated
with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and
the gut microbiota may interact with both disease entities ... Our findings
suggest that MDD may hold a dysmetabolic component that responds to probiotic
treatment. This finding has wide implications owing to the high metabolic
comorbidity in MDD. Furthermore, the close association between depressive-like
behaviour and cerebral T cell populations demonstrate lymphocyte-brain
interactions as a promising future research area in the field of
psychoneuroimmunology" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
A preliminary examination
of gut microbiota, sleep, and cognitive flexibility in healthy older adults
- Sleep Med. 2017 Oct;38:104-107 - "Better sleep quality
was associated with better Stroop performance and higher proportions of the gut
microbial phyla Verrucomicrobia and Lentisphaerae. Stroop Word and Color-Word
performance correlated with higher proportions of Verrucomicrobia and
Lentisphaerae. Partial correlations suggested that the relationship between
Lentisphaerae and Stroop Color-Word performance was better accounted for by
sleep quality; sleep quality remained a significant predictor of Color-Word
performance, independent of the Lentisphaerae proportion, while the relationship
between Lentisphaerae and Stroop performance was non-significant.
Verrucomicrobia and sleep quality were not associated with Stroop Word
performance independent of one another" - [Nutra
USA]
-
Effect of Probiotics and
Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic
Review and Meta-Analysis of Randomized Controlled Trials - Nutrients. 2017
Oct 27;9(11) - "Participants who took probiotics or prebiotics showed
significant improvements in the H1N1 strain seroprotection rate (with an odds
ratio (OR) of 1.83 and a 95% confidence interval (CI) of 1.19-2.82, p = 0.006,
I² = 0%), the H3N2 strain seroprotection rate (OR = 2.85, 95% CI = 1.59-5.10, p
< 0.001, I² = 0%), and the B strain seroconversion rate (OR = 2.11, 95% CI =
1.38-3.21, p < 0.001, I² = 0%). This meta-analysis suggested that probiotics and
prebiotics are effective in elevating immunogenicity by influencing
seroconversion and seroprotection rates in adults inoculated with influenza
vaccines" - See
probiotic products at Amazon.com.
-
Effects of
microencapsulated Lactobacillus plantarum LIP-1 on the gut microbiota of
hyperlipidaemic rats - Br J Nutr. 2017 Oct;118(7):481-492 -
"microcapsulation
enhanced the colon colonisation of LIP-1 cells, which subsequently exhibited
more pronounced effects in improving the gut microbiota composition of
hyperlipidaemic rats and lipid reduction" - See
microencapsulated probiotics at Amazon.com.
-
The effect of probiotics
as a treatment for constipation in elderly people: A systematic review -
Arch Gerontol Geriatr. 2017 Jul;71:142-149 - "Overall,
our analysis of the randomised and placebo-controlled trials suggests that
administration of probiotics significantly improved constipation in elderly
individuals by 10-40% compared to placebo controls in which no probiotic was
administered" - [Nutra
USA]
-
Synbiotic supplementation
and the effects on clinical and metabolic responses in patients with rheumatoid
arthritis: a randomised, double-blind, placebo-controlled trial - Br J Nutr.
2017 May 11:1-8 - "After the 8-week intervention,
compared with the placebo, synbiotic supplementation resulted in a significant
reduction in serum high-sensitivity C-reactive protein (hs-CRP) levels (-1427·8
(sd 3267·2) v. +2833·4 (sd 5639·7) ng/ml, P=0·001). In addition, compared with
the placebo, synbiotic supplementation improved disease activity score-28 joints
(DAS-28) (-1·6 (sd 0·8) v. -0·3 (sd 0·5), P<0·001) and visual analogue scales
(VAS) pain (-30·4 (sd 18·7) v. -11·5 (sd 15·9), P<0·001). In addition, a
significant elevation in plasma nitric oxide (NO) (+0·8 (sd 4·4) v. -2·6 (sd
4·5) µmol/l, P=0·008), and significant reductions in insulin values (-13·8 (sd
26·4) v. +4·2 (sd 28·2) pmol/l, P=0·01), homoeostasis model of
assessment-estimated insulin resistance (HOMA-IR) (-0·5 (sd 1·0) v.+0·1 (sd
1·1), P=0·03) and homoeostatic model assessment-β-cell function (HOMA-B) (-9·4 (sd
17·9) v. +3·3 (sd 18·9), P=0·01) following supplementation with the synbiotic
compared with the placebo. Compared with the placebo, synbiotic supplementation
also resulted in a significant increase in plasma GSH (+36·6 (sd 63·5) v. -58·5
(sd 154·4) µmol/l, P=0·005). Overall, our study demonstrated that synbiotic
supplementation for 8 weeks among patients with RA had beneficial effects on hs-CRP,
DAS-28, VAS, NO, insulin levels, HOMA-IR, HOMA-B and GSH levels" - See
synbiotic supplements at Amazon.com.
-
Gastrointestinal Microbiota and Cognitive Function in Adult Females - fasebj,
Apr 2017 - "These results indicate that women with greater relative abundances
of Bacteriodetes exhibited greater ability to maintain cognitive performance
when faced with greater task demands. These findings are among the first to
relate bacterial phylogenetic characteristics to executive function among adult
humans. Further study is required to elucidate a causal relationship between
dietary manipulation of microbiota composition and changes in selective aspects
of cognitive performance" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
Age-Associated Microbial
Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and
Macrophage Dysfunction - Cell Host Microbe. 2017 Apr 12 -
"Levels of
inflammatory mediators in circulation are known to increase with age, but the
underlying cause of this age-associated inflammation is debated ... These data
suggest that aging-associated microbiota promote inflammation and that reversing
these age-related microbiota changes represents a potential strategy for
reducing age-associated inflammation and the accompanying morbidity" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
Probiotics (Lactobacillus
gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2)
improve rhinoconjunctivitis-specific quality of life in individuals with
seasonal allergies: a double-blind, placebo-controlled, randomized trial -
Am J Clin Nutr. 2017 Feb 22 - "The probiotic group
reported an improvement in the MRQLQ global score from baseline to pollen peak
(-0.68 ± 0.13) when compared with the placebo group (-0.19"
-
Probiotics and
Subclinical Psychological Symptoms in Healthy Participants: A Systematic Review
and Meta-Analysis - J Altern Complement Med. 2016 Nov 14 -
"These results show that probiotic consumption may have
a positive effect on psychological symptoms of depression, anxiety, and
perceived stress in healthy human volunteers"
-
Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum
Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial -
j.ebiom.2016.10.036 - "We investigated the possible effects of Bifidobacterium
animalis ssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra
polydextrose (LU) on body fat mass and other obesity-related parameters ... For
relative change in body fat mass, LU + B420 showed a − 4.5% (−1.4 kg, P = 0.02,
N = 37) difference to the Placebo group, whereas LU (+0.3%, P = 1.00, N = 35)
and B420 (−3.0%, P = 0.28, N = 24) alone had no effect (overall ANOVA P = 0.095,
Placebo N = 35). A post-hoc factorial analysis was significant for B420 (−4.0%,
P = 0.002 vs. Placebo). Changes in fat mass were most pronounced in the
abdominal region, and were reflected by similar changes in waist circumference.
B420 and LU + B420 also significantly reduced energy intake compared to Placebo"
- [Nutra
USA] - See
probiotic products at Amazon.com
and polydextrose at Amazon.com.
-
Anti-obese effects of two
Lactobacilli and two Bifidobacteria on ICR mice fed on a high fat diet -
Biochem Biophys Res Commun. 2016 Nov 11;480(2):222-227 -
"high fat diet (HFD) ... The beneficial effects of the probiotic bacteria are
suggested to be strain dependent. In this study, two candidate lactobacteria
strains, Lactobacillus casei IBS041, Lactobacillus acidophilus AD031 and two
bifidobacteria strains, Bifidobacterium bifidum BGN4 and Bifidobacterium longum
BORI, were individually administered to HFD-fed mice for 8 weeks. B. longum BORI
significantly suppressed mouse weight gain without affecting food intake. L.
acidophilus and B. bifidum BGN4 significantly decreased triglyceride levels in
mouse liver while B. longum BORI significantly lowered total cholesterol levels
in liver. L. acidophilus and B. bifidum BGN4 significantly inhibited serum
activities of aspartate transaminase and alanine transaminase. Diet
supplementation with L. acidophilus, B. bifidum BGN4 and B. longum BORI
efficiently improved hepatocyte hydropic degeneration and hepatic steatosis. Of
the four probiotic candidates, the bifidobacteria B. longum BORI and B. bifidum
BGN4, developed in our laboratory, and L. acidophilus AD031showed excellent
anti-obesity effects and suppressed lipid deposition in liver"
-
The use of probiotic L.
fermentum ME-3 containing Reg'Activ Cholesterol supplement for 4 weeks has a
positive influence on blood lipoprotein profiles and inflammatory cytokines: an
open-label preliminary study - Nutr J. 2016 Oct 28;15(1):93 -
"Reg'Activ Cholesterol (RAC) ... Forty-five clinically
asymptomatic participants consumed an RAC containing an antioxidative and
antiatherogenic probiotic Lactobacillus fermentum ME-3 (LFME-3) for 4 weeks ...
The reduction of total cholesterol (from 6.5 ± 1.0 to 5.7 ± 0.9 mmol/l,
p = 9.90806E-11) was on the account of LDL cholesterol as the HDL cholesterol
level rose from 1.60 ± 0.31to 1.67 ± 0.34mml/l, p = 0.01. HbA1c% was reduced
from 5.85 ± 0.28 to 5.66 ± 0.25 p = 4.64E-05 and oxLDL decreased from 84 ± 20 to
71 ± 15 U/l" - See Reg'Activ Cholesterol
at Amazon.com.
-
Probiotic Streptococcus
thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates
Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise
- Nutrients. 2016 Oct 14;8(10) - "Probiotic
supplementation resulted in an overall decrease in circulating IL-6, which was
sustained to 48 h post-exercise. In addition, probiotic supplementation likely
enhanced isometric average peak torque production at 24 to 72 h into the
recovery period following exercise (probiotic-placebo point effect ±90% CI: 24
h, 11% ± 7%; 48 h, 12% ± 18%; 72 h, 8% ± 8%). Probiotics also likely moderately
increased resting arm angle at 24 h (2.4% ± 2.0%) and 48 h (1.9% ± 1.9%)
following exercise, but effects on soreness and flexed arm angle and CK were
unclear. These data suggest that dietary supplementation with probiotic strains
S. thermophilus FP4 and B. breve BR03 attenuates performance decrements and
muscle tension in the days following muscle-damaging exercise" - [Nutra
USA] - See Garden of Life Primal Defense
ULTRA 180 Capsules at Amazon.com.
-
Efficacy of Synbiotics in
Patients with Slow Transit Constipation: A Prospective Randomized Trial -
Nutrients. 2016 Sep 28;8(10) - "A total of 100 patients with slow transit
constipation were randomized to receive either a synbiotic or placebo twice
daily for 12 weeks ... Over 12 weeks, 64.6% of the patients who received the
synbiotic experienced clinical improvement, compared to 29.2% of the patients in
the placebo group (p < 0.01). During the intervention period, patients who were
treated with the synbiotic exhibited increased stool frequency, improved stool
consistency, decreased CTT, and improved constipation-related symptoms"
- [Nutra USA] -
See
synbiotic products at Amazon.com,
probiotic products at Amazon.com
and
inulin at Amazon.com.
-
The effects of synbiotic
supplementation on markers of insulin metabolism and lipid profiles in
gestational diabetes: a randomised, double-blind, placebo-controlled trial -
Br J Nutr. 2016 Sep 29:1-8 - "Patients in the synbiotic
group received a daily capsule that contained three viable and freeze-dried
strains: Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium
bifidum (2×109 colony-forming units/g each) plus 800 mg inulin for 6 weeks ...
After 6 weeks of intervention, compared with the placebo, synbiotic
supplementation led to a significant decrease in serum insulin levels (-1·5 (sd
5·9) v. +4·8 (sd 11·5) µIU/ml, P=0·005), homoeostatic model assessment for
insulin resistance (-0·4 (sd 1·3) v. +1·1 (sd 2·7), P=0·003) and homoeostatic
model assessment for β cell function (-5·1 (sd 24·2) v. +18·9 (sd 45·6),
P=0·008) and a significant increase in quantitative insulin sensitivity check
index (+0·01 (sd 0·01) v. -0·007 (sd 0·02), P=0·02). In addition, synbiotic
intake significantly decreased serum TAG (-14·8 (sd 56·5) v. +30·4 (sd 37·8)
mg/dl, P<0·001) and VLDL-cholesterol concentrations (-3·0 (sd 11·3) v. +6·1 (sd
7·6) mg/dl, P<0·001) compared with the placebo" - [Nutra
USA] - See
synbiotic products at Amazon.com,
probiotic products at Amazon.com
and
inulin at Amazon.com.
-
Impact of Chlorhexidine
Pretreatment Followed by Probiotic Streptococcus salivarius Strain K12 on
Halitosis in Children: A Randomised Controlled Clinical Trial - Oral Health
Prev Dent. 2016;14(4):305-13 - "Probiotic therapy
following oral disinfection with chlorhexidine may reduce the severity of
halitosis over longer periods" - [Nutra
USA]
-
Probiotic and synbiotic
therapy in critical illness: a systematic review and meta-analysis - Crit
Care. 2016 Aug 19;19:262 - "Thirty trials that enrolled
2972 patients were identified for analysis. Probiotics were associated with a
significant reduction in infections (risk ratio 0.80, 95 % confidence interval
(CI) 0.68, 0.95, P = 0.009; heterogeneity I (2) = 36 %, P = 0.09). Further, a
significant reduction in the incidence of ventilator-associated pneumonia (VAP)
was found (risk ratio 0.74"
-
Clinical Evidence of
Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double
Blind, Placebo-Controlled Study - J Microbiol Biotechnol. 2015 Dec
28;25(12):2160-8 - "Participants took 1 × 10(10) CFU/day
of HY7714 (probiotic group) or a placebo (placebo group) for 12 weeks. Skin
hydration, wrinkles, skin gloss, and skin elasticity were measured every 4 weeks
during the study period. There were significant increases in the skin water
content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the probiotic
group. Transepidermal water loss decreased significantly in both groups at weeks
4, 8, and 12 (p < 0.001 compared with baseline), and was suppressed to a greater
extent in the face and forearm in the probiotic group at week 12. Volunteers in
the probiotic group had a significant reduction in wrinkle depth at week 12, and
skin gloss was also significantly improved by week 12. Finally, skin elasticity
in the probiotic group improved by 13.17% (p < 0.05 vs. controls) after 4 weeks
and by 21.73% (p < 0.01 vs. controls) after 12 weeks. These findings are
preliminary confirmation of the anti-aging benefit to the skin of L. plantarum
HY7714 as a nutricosmetic agent" - [Nutra
USA] - See Garden of Life Primal Defense
ULTRA, 180 Capsules at Amazon.com.
-
Probiotic mixture VSL#3
reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE(-/-)
mice - AMB Express. 2016 Dec;6(1):61 - "ApoE(-/-)
mice were fed high fat diet alone or with VSL#3 or a positive control treatment,
telmisartan or both for 12 weeks. All treatments reduced atherosclerotic plaques
significantly compared to high fat diet alone. VSL#3 significantly reduced
proinflammatory adhesion molecules and risk factors of plaque rupture, reduced
vascular inflammation and atherosclerosis to a comparable extent to telmisartan;
and VSL#3 treated mice had the most distinctly different intestinal microbiota
composition from the control groups. Combining the VSL#3 and telmisartan brought
no further benefits. Our findings showed the therapeutic potential of VSL#3 in
reducing atherosclerosis and vascular inflammation" - [Nutra
USA]
-
Effect of Probiotics on
Depression: A Systematic Review and Meta-Analysis of Randomized Controlled
Trials - Nutrients. 2016 Aug 6;8(8) - "It has been
reported that gut probiotics play a major role in the bidirectional
communication between the gut and the brain. Probiotics may be essential to
people with depression, which remains a global health challenge, as depression
is a metabolic brain disorder ... Probiotics had an effect on both the healthy
population (MD = -0.25, 95% CI (-0.47--0.03), p = 0.03) and patients with major
depressive disorder (MDD) (MD = -0.73, 95% CI (-1.37--0.09), p = 0.03) ...
probiotics were associated with a significant reduction in depression"
-
Probiotic Bacillus coagulans GBI-30,
6086 reduces exercise-induced muscle damage and increases recovery - PeerJ
Jul 21, 2016 - "The strenuous exercise significantly
reduced athletic performance in PRO (Wingate Peak Power; PRO: (−39.8 watts,
−5.3%, p = 0.03)), whereas PROBC maintained performance (+10.1 watts, +1.7%) ...
The results provide evidence that probiotic supplementation in combination with
protein tended to reduce indices of muscle damage, improves recovery, and
maintains physical performance subsequent to damaging exercise" - [Nutra
USA]
-
Probiotics for the
management of type 2 diabetes mellitus: A systematic review and meta-analysis
- Diabetes Res Clin Pract. 2016 Jun 18 - "fasting blood
glucose (FBG) ... When compared to placebo, FBG was significantly lower with
probiotic consumption (MD=-0.98mmol/L; 95% CI: -1.17, 0.78, p<0.00001), with
moderate but insignificant heterogeneity noted"
-
Pterostilbene-induced
changes in gut microbiota composition in relation to obesity - Mol Nutr Food
Res. 2016 Jul 5 - "gut microbiota (GM) ... Pterostilbene
exerted protective anti-obesity effects, improved metabolic function (insulin
sensitivity) and induced structural changes in GM composition ... Pterostilbene
modifies intestinal bacteria composition towards a healthier microbial profile
and suggests that the anti-obesity effects induced in Zucker rats could be
associated with an enrichment of the mucin-degrading bacterial members, namely
Akkermansia and Odoribacter genus"
-
Probiotic Lactobacillus
gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats
by stimulating energy expenditure - Br J Nutr. 2016 Jun 8:1-8 -
"Probiotic Lactobacillus gasseri SBT2055 (LG2055)
reduces postprandial TAG absorption and exerts anti-obesity effects in rats and
humans; however, the underlying mechanisms are not fully understood ... Rats fed
the LG2055-containing diet demonstrated significantly higher carbohydrate
oxidation in the dark cycle (active phase for rats) compared with the control
group, which resulted in a significant increase in energy expenditure. LG2055
significantly reduced cumulative blood glucose levels (AUC) compared with the
control diet after 3 weeks and increased the molar ratio of butyrate:total SCFA
in the caecum after 4 weeks. Furthermore, the LG2055-supplemented diet
significantly reduced the levels of serum amyloid P component - an indicator of
the inflammatory process" - See
probiotic products at Amazon.com.
-
Effects of high doses of
vitamin D3 on mucosa-associated gut microbiome vary between regions of the human
gastrointestinal tract - Eur J Nutr. 2016 Jun;55(4):1479-89 -
"We sampled stomach, small bowel, colon, and stools
before and after 8 weeks of vitamin D3 supplementation ... Vitamin D3 modulates
the gut microbiome of the upper GI tract which might explain its positive
influence on gastrointestinal diseases, such as inflammatory bowel disease or
bacterial infections" - [Nutra
USA]
-
Beneficial effects of
Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic
syndrome: A randomized trial. Effects of probiotics on metabolic syndrome -
Nutrition. 2016 Jun;32(6):716-9 - "Daily ingestion of 80
mL fermented milk with 2.72 × 10(10) colony-forming units of B. lactis HN019
showed significant reduction in body mass index (P = 0.017), total cholesterol
(P = 0.009), and low-density lipoprotein (P = 0.008) compared with baseline and
control group values. Furthermore, a significant decrease in tumor necrosis
factor-α (P = 0.033) and interleukin-6 (P = 0.044) proinflammatory cytokines was
observed" - [Nutra
USA] - Note: Bifidobacterium lactis is one of the bacterial in the
Garden of Life Primal Defense ULTRA I take.
-
Effect of
probiotics on body weight and body-mass index: a systematic review and
meta-analysis of randomized, controlled trials - Int J Food Sci Nutr. 2016
May 5 - "Probiotic consumption significantly reduced
body weight by 0.59 kg (95% CI, 0.30-0.87) and BMI by 0.49 kg/m2 (95% CI,
0.24-0.74). A greater reduction in BMI was found with multiple species of
probiotics. Subgroup analysis of trials with intervention duration ≥8 weeks
found a more significant reduction in BMI. Limiting analysis to trials with a
baseline BMI ≥25 kg/m2 showed a greater reduction in BMI" - See
probiotic products at Amazon.com.
-
Lactobacillus
plantarum TWK10 Supplementation Improves Exercise Performance and
Increases Muscle Mass in Mice - Nutrients 2016, 8(4), 205 -
"Lactobacillus plantarum (L. plantarum) is a well-known
probiotic among the ingested-microorganism probiotic ... few studies have
examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise
performance, physical fatigue, and gut microbial profile ... LP10 significantly
decreased final body weight and increased relative muscle weight (%). LP10
supplementation dose-dependently increased grip strength (p < 0.0001) and
endurance swimming time (p < 0.001) and decreased levels of serum lactate (p <
0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p =
0.0151) after acute exercise challenge. The number of type I fibers (slow
muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In
addition, serum levels of albumin, blood urea nitrogen, creatinine, and
triacylglycerol significantly decreased with LP10 treatment. Long-term
supplementation with LP10 may increase muscle mass, enhance energy harvesting,
and have health-promotion, performance-improvement, and anti-fatigue effects"
- [Nutra
USA] -Note: Lactobacillus plantarum is the top probiotic in the
Garden of Life Primal Defense Ultra that I
take.
-
Protective
effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat
diet-induced obese mice - Biochem Biophys Res Commun. 2016 Mar 23 -
"Recent reports suggest that gut microbiota can be a
major determinant of dyslipidemia and non-alcoholic fatty liver disease (NAFLD)
and its modulation by treating probiotics is a valid strategy to exert a
protective effect. In this study, high-fat diet (HFD)-fed mice were orally
administrated with Lactobacillus rhamnosus GG (LGG) for 13 weeks. Significant
reductions in the weights of the liver, mesenteric and subcutaneous adipose
tissues were observed in LGG-treated HFD-fed mice compared to LGG-non-treated
controls. The serum levels of triglyceride and cholesterol were also
significantly reduced in LGG-treated mice. Gut microbial composition analysis
showed that shifts in the diversity of dominant gut bacteria were caused by HFD
and restored by LGG treatment. A remarkable decrease of hepatic fat content was
also observed in LGG-treated mice, accompanied by downregulated expressions of
lipogenic and pro-inflammatory genes in the liver. LGG-treated mice had lower
expression levels of genes involved in cholesterol synthesis, but conversely,
higher expression levels of cholesterol efflux-related genes compared to
LGG-non-treated controls"
-
Clinical efficacy of
probiotic as an adjunctive therapy to non-surgical periodontal treatment of
chronic periodontitis: A systematic review and meta-analysis - J Clin
Periodontol. 2016 Mar 1 - "root planing (SRP) ...
chronic periodontitis (CP) ... Meta-analysis showed a statistically significant
CAL gain (-0.42 mm, p=0.002) and bleeding on probing (BOP) reduction (-14.66,
p=0.003) for SRP + probiotic treatment versus SRP at short-term. Only a tendency
(p=0.06) has been observed in terms of overall PPD reduction, whereas results
were significant when stratified for moderate (-0.18, p=0.001) and deep pockets
(-0.67" - [Nutra
USA]
-
'Psychobiotic' May Help
Ease Stress, Improve Memory - Medscape, 10/20/15 -
"The emerging concept of the gut microbiome as a key regulator of brain and
behavior represents a paradigm shift in neuroscience. Precise targeting of the
microbiome-gut-brain axis with psychobiotics — live microorganisms with a
potential mental health benefit — is a novel approach for the management of
stress-related conditions ... 22 healthy male volunteers (mean age, 25.5 years)
ingested a capsule containing B longum NCIMB 41676 daily for 4 weeks and a
matching placebo capsule for another 4 weeks ... B longum NCIMB 41676 led to a
reduction in cumulative output of the stress hormone cortisol, as well as a
blunted increase in subjective anxiety. On the questionnaire, the men reported
being less stressed and anxious while taking the probiotic. They also showed
subtle improvement on a visual memory task after receiving the probiotic, as
well as altered EEG output" - See
probiotic products at Amazon.com.
-
Effects of
Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in
Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized
Clinical Trial - J Am Coll Nutr. 2015 Oct 2:1-6 -
"Nonalcoholic fatty liver disease (NAFLD) is a condition defined by exceeding
triglycerides accumulation in the liver. The condition can develop into
fibrosis, cirrhosis, and hepatocellular carcinoma ... Subjects in the
intervention and control groups consumed 2 capsules/day probiotic or placebo,
respectively, for 8 weeks. Fasting blood sugar (FBS) ... Means of FBS, insulin,
insulin resistance, and IL-6 were significantly different between groups after
intervention (p < 0.05), whereas TNF-α was not significantly modified (p >
0.05). In the probiotic group, insulin, insulin resistance, TNF-α, and IL-6
decreased significantly at the end of the study compared to the beginning of
study" - See
probiotic products at Amazon.com.
-
Effect of the probiotic
strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency
in healthy subjects with low defecation frequency and abdominal discomfort: a
randomised, double-blind, placebo-controlled, parallel-group trial - Br J
Nutr. 2015 Sep 18 - "The OR for having a defecation
frequency above baseline for ≥50 % of the time was 1.31 (95 % CI 0.98, 1.75),
P=0.071, for probiotic treatment overall. Tightening the criteria for being a
responder to an increase of ≥1 d/week for ≥50 % of the time resulted in an OR of
1.55 ... A treatment effect on average defecation frequency was found
(P=0.0065), with the frequency being significantly higher compared with placebo
at all weeks for probiotic treatment overall (all P<0.05). Effects on defecation
frequency were similar for the two doses tested, suggesting that a ceiling
effect was reached with the one billion dose. Overall, 4 weeks' supplementation
with the probiotic strain BB-12® resulted in a clinically relevant benefit on
defecation frequency" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
The impact
of gut microbiota on brain and behaviour: implications for psychiatry - Curr
Opin Clin Nutr Metab Care. 2015 Sep 12 - "Recently, the
gut microbiota has been profiled in a variety of conditions including autism,
major depression and Parkinson's disease ... The current narrative suggests that
certain neuropsychiatric disorders might be treated by targeting the microbiota
either by microbiota transplantation, antibiotics or psychobiotics"
-
Probiotics
Improve Inflammation-Associated Sickness Behavior by Altering Communication
between the Peripheral Immune System and the Brain - J Neurosci. 2015 Jul 29
- "Patients with systemic inflammatory diseases (e.g.,
rheumatoid arthritis, inflammatory bowel disease, chronic liver disease)
commonly develop debilitating symptoms (i.e., sickness behaviors) that arise
from changes in brain function. The microbiota-gut-brain axis alters brain
function and probiotic ingestion can influence behavior ... This research shows
that probiotics, when eaten, can improve the abnormal behaviors (including
social withdrawal and immobility) that are commonly associated with
inflammation. Probiotics are able to cause this effect within the body by
changing how the immune system signals the brain to alter brain function. These
findings broaden our understanding of how probiotics may beneficially affect
brain function in the context of inflammation occurring within the body and may
open potential new therapeutic alternatives for the treatment of these
alterations in behavior that can greatly affect patient quality of life"
-
Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and
Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances
apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia
- Atherosclerosis. 2015 Jun 18 - "After the treatment,
the probiotic group showed an 18.3% (P < 0.001) reduction in TGs and increases
of 21.1% (P = 0.001) and 15.6% (P < 0.001) in the apo A-V and LDL particle size,
respectively. The probiotic group had a significant reduction in TGs (P = 0.040)
and increases in the plasma apo A-V (P = 0.003) and LDL particle size (P <
0.001) compared with the placebo group"
-
Symbiotics
in irritable bowel syndrome - better than probiotics alone? - Curr Opin Clin
Nutr Metab Care. 2015 Jun 23 - "Probiotics appear to be
beneficial in IBS. Data supporting the use of symbiotics is sparse. Whether
symbiotics are superior to probiotics is unclear"
-
The
triglyceride-lowering effect of supplementation with dual probiotic strains,
Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of
fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic
subjects - Nutr Metab Cardiovasc Dis. 2015 May 14 -
"After 12 weeks of treatment, the probiotic group displayed a 20% reduction (p =
0.001) in serum TGs and 25% increases (p=0.001) in apolipoprotein A-V (apoA-V).
At the 12-week follow-up assessment, the following 11 plasma metabolites were
significantly reduced in the probiotic group than the placebo group"
-
Probiotics
as beneficial agents on the management of diabetes mellitus: a systematic review
- Diabetes Metab Res Rev. 2015 May 11 - "We found that probiotics have
beneficial effects on glycemic controls, as all human studies showed significant
reductions in at least one of the primary outcome endpoints which were the
levels of fasting plasma glucose, postprandial blood glucose, glycated
hemoglobin, insulin, insulin resistance and onset of diabetes; similarly, all
the animal reports, except for two, documented significant changes in these
parameters"
-
The effects
of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A
randomized, double-blind, placebo-controlled trial in petrochemical workers
- Nutr Neurosci. 2015 Apr 16 - "divided into three
groups to receive 100 g/day probiotic yogurt + one placebo capsule (n = 25) or
one probiotic capsule daily + 100 g/day conventional yogurt (n = 25) or 100
g/day conventional yogurt + one placebo capsule (n = 20) for 6 weeks. Mental
health parameters including general health questionnaire (GHQ) and depression
anxiety and stress scale (DASS) scores were measured ... After 6 weeks of
intervention, a significant improvement of GHQ was observed in the probiotic
yogurt (18.0 ± 1.5 vs. 13.5 ± 1.9, P = 0.007) and in the probiotic capsule group
(16.9 ± 1.8 vs. 9.8 ± 1.9, P = 0.001), as well as a significant improvement in
DASS scores in the probiotic yogurt (23.3 ± 3.7 vs. 13.0 ± 3.7, P = 0.02) and
the probiotic capsule group (18.9 ± 3.2 vs. 9.4 ± 4.0, P = 0.006). However,
there was no significant improvement in the conventional yogurt group (P = 0.05
for GHQ and P = 0.08 for DASS)"
-
Gut
Dysbiosis Is Linked to Hypertension - Hypertension. 2015 Apr 13 -
"These observations demonstrate that high blood pressure
is associated with gut microbiota dysbiosis, both in animal and human
hypertension. They suggest that dietary intervention to correct gut microbiota
could be an innovative nutritional therapeutic strategy for hypertension"
-
People
less focused on recurrent bad feelings when taking probiotics - Science
Daily, 4/14/15 - "Rumination is one of the most
predictive vulnerability markers of depression ... Compared to subjects who
received the placebo intervention, participants who received the multispecies
probiotics intervention showed significantly reduced ruminative thoughts ...
Even if preliminary, these results provide the first evidence that the intake of
probiotics may help reduce negative thoughts associated with sad mood. As such,
our findings shed an interesting new light on the potential of probiotics"
-
Probiotic
supplementation prevents high-fat, overfeeding-induced insulin resistance in
human subjects - Br J Nutr. 2015 Jan 29:1-7 - "The
purpose of the present study was to determine whether probiotic supplementation
(Lactobacillus casei Shirota (LcS)) prevents diet-induced insulin resistance in
human subjects. A total of seventeen healthy subjects were randomised to either
a probiotic (n 8) or a control (n 9) group ... Glucose AUC values increased by
10 % (from 817 (se 45) to 899 (se 39) mmol/l per 120 min, P< 0.05) and
whole-body insulin sensitivity decreased by 27 % (from 5.3 (se 1.4) to 3.9 (se
0.9), P< 0.05) in the control group, whereas normal insulin sensitivity was
maintained in the probiotic group (4.4 (se 0.8) and 4.5 (se 0.9) before and
after overeating, respectively (P>0.05). These results suggest that probiotic
supplementation may be useful in the prevention of diet-induced metabolic
diseases such as type 2 diabetes"
-
Bifidobacterium bifidum R0071 results in a greater proportion of healthy days
and a lower percentage of academically stressed students reporting a day of
cold/flu: a randomised, double-blind, placebo-controlled study - Br J Nutr.
2015 Jan 21:1-9 - "B. bifidum resulted in a greater
proportion of healthy days than placebo (P≤ 0·05). The percentage of
participants reporting ≥ 1 d of cold/flu during the 6-week intervention period
was significantly lower with B. bifidum than with placebo (P< 0·05) ... The
proportion of participants reporting a cold on any given day was lower at weeks
2 and 3 with B. bifidum and B. infantis than with placebo for the average level
of stress and the most commonly reported number of hours of sleep. Daily intake
of bifidobacteria provides benefit related to cold/flu outcomes during acute
stress"
-
The
Protective Effects Of Selenium-enriched Probiotics On Carbon
Tetrachloride-induced Liver Fibrosis In Rats - J Agric Food Chem. 2014 Dec
16 - "Se-enriched probiotics (SP) ... SP significantly
decreased serum alanine aminotransferase (48.2%), aspartate aminotransferase
(26.8%), hepatic hydroxyproline (29.3%) and malondialdehyde (30.1%) levels"
- See
se-methyl l-selenocysteine at Amazon.com
and
probiotic products at Amazon.com.
-
A systematic
review and meta-analysis of the prebiotics and synbiotics effects on glycaemia,
insulin concentrations and lipid parameters in adult patients with overweight or
obesity - Clin Nutr. 2014 Oct 20 - "Thirteen trials,
representing 513 adult participants with Body Mass Index ≥25 kg/m² were
included. Prebiotic supplementation reduced plasma total cholesterol (SMD -0.25;
95% CI -0.48, -0.02) and LDL-c (SMD -0.22; 95% CI -0.44, -0.00) concentrations
in overall analysis, and reduced triglycerides (SMD -0.72; 95% CI -1.20, -0.23)
and increased HDL-c (SMD 0.49; 95% CI 0.01, 0.97) concentrations in diabetic
trials. Synbiotic supplementation reduced plasma fasting insulin (SMD -0.39; 95%
CI -0.75, -0.02) and triglycerides (SMD -0.43; 95% CI -0.70, -0.15)
concentrations"
-
Impact of
personalized diet and probiotic supplementation on inflammation, nutritional
parameters and intestinal microbiota - The "RISTOMED project": Randomized
controlled trial in healthy older people - Clin Nutr. 2014 Oct 8 -
"Addition of VSL#3 increased bifidobacteria and
supported adequate folate and vitamin B12 concentrations in subjects with
low-grade inflammation. Decrease in homocysteine with VSL#3 was clinically
relevant. suggesting protective potentials for aging-associated conditions, e.g.
cardiovascular or neurological diseases"
-
Brain and
liver fatty acid composition changes upon consumption of Lactobacillus rhamnosus
LA68 - Int J Food Sci Nutr. 2014 Nov 28:1-5 - "This
study was designed to test the effects of a particular Lactobacillus strain,
Lactobacillus rhamnosus LA68 on fatty acid composition of the liver and the
brain of C57BL/6 mice in the absence of an underlying pathological condition.
Female mice were supplemented with live L. rhamnosus LA68 bacteria for the
duration of 1 month ... Significant changes in liver and brain fatty acid
composition were detected. In the liver tissue we detected an increase in
palmitoleic acid (p = 0.038), while in the brain compartment we found an
increase in palmitic (p = 0.042), stearic (p = 0.017), arachidonic acid
(p = 0.009) and docosahexaenoic acid (p = 0.004) for control versus experimental
group. These results show discrete changes caused by LA68 strain consumption.
Even short duration of administration of LA68 influences the fatty acid
composition of the host which adds to the existing knowledge about Lactobacillus
host interaction, and adds to the growing knowledge of metabolic intervention
possibilities"
-
Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight
gain and glucose intolerance in diet-induced obese mice - Benef Microbes.
2014 Dec 1;5(4):437-45 - "Treatment with B. lactis 420 significantly decreased
fat mass in obese (7.83 ± 0.67 g, P=0.007 compared to obese with vehicle) and
diabetic mice (1.89 ± 0.16 g, P=0.02 for highest dose). This was reflected as
reduced weight gain and improved glucose tolerance. Furthermore, B. lactis 420
decreased plasma lipopolysaccharide levels (P<0.001), liver inflammation
(P=0.04), and E. coli adhesion in the distal gut (P<0.05)" - [Nutra
USA] - See Bifidobacterium animalis products at Amazon.com.
-
A 10-Patient
Case Study on the Influence of Two Different Probiotics on Individual Intestinal
Microbiota - J Altern Complement Med. 2014 Sep 24 -
"Ten outpatients were enrolled. Study A: Five patients took Lactobacillus
buchneri (SU) for 4 weeks and mixed probiotics (NS) for the following 4 weeks.
Study B: One year after study A, the other five patients took NS for 4 weeks at
first and SU for the following 4 weeks ... Study A: Three of the five patients
had a decreased percentage of beneficial bacteria (Lactobacillales,
Bifidobacteria species) after taking SU ... All five patients had increased
beneficial bacteria after taking NS" - See
probiotic products at Amazon.com.
-
Probiotics
and vitamin C for the prevention of respiratory tract infections in children
attending preschool: a randomised controlled pilot study - Eur J Clin Nutr.
2014 Sep 10 - "children aged 3-6 years, 57 received 1.25
× 1010 colony-forming units of Lactobacillus acidophilus CUL21 (NCIMB 30156),
Lactobacillus acidophilus CUL60 (NCIMB 30157), Bifidobacterium bifidum CUL20
(NCIMB 30153) and Bifidobacterium animalis subsp. lactis CUL34 (NCIMB 30172)
plus 50 mg vitamin C or a placebo daily for 6 months.Results:Significant
reductions in the incidence rate of upper respiratory tract infection (URTI;
33%, P=0.002), the number of days with URTI symptoms (mean difference: -21.0,
95% confidence interval (CI):-35.9, -6.0, P=0.006) and the incidence rate of
absence from preschool (30%, P=0.007) were observed in the active group compared
with the placebo. The number of days of use of antibiotics, painkillers, cough
medicine or nasal sprays was lower in the active group and reached significance
for use of cough medicine (mean difference: -6.6, 95% CI: -12.9, -0.3, P=0.040)"
- [Nutra
USA]
-
Consuming probiotics for a month helps diminish fat accumulation in the liver,
according to a new study - Science Daily, 7/18/14 -
"In this current study, the strains were administered during thirty days in the
diet of Zucker rats ... the administration of probiotics led to an accumulation
of lipids (most of them triacylglycerides) in the liver which was significantly
lower than that occurring in rats fed with a placebo" - See
probiotic products at Amazon.com.
-
Effects of
synbiotic supplementation on insulin resistance in subjects with the metabolic
syndrome: a randomised, double-blind, placebo-controlled pilot study - Br J
Nutr. 2014 May 22:1-8 - "placebo-controlled pilot study on thirty-eight subjects
with the metabolic syndrome; they were supplemented with either synbiotic
capsules containing 200 million of seven strains of friendly bacteria plus
fructo-oligosaccharide or placebo capsules twice a day for 28 weeks ... After 28
weeks of treatment, the levels of fasting blood sugar and insulin resistance
improved significantly in the G1 group" - See synbiotic products at Amazon.com,
probiotic products at Amazon.com
and fructo-oligosaccharide at Amazon.com.
-
Effectiveness of probiotics on the duration of illness in healthy children and
adults who develop common acute respiratory infectious conditions: a systematic
review and meta-analysis - Br J Nutr. 2014 Apr 29:1-14 -
"Meta-analysis revealed significantly fewer numbers of
days of illness per person (standardised mean difference (SMD) - 0.31 (95 % CI -
0.41, - 0.11), I 2= 3 %), shorter illness episodes by almost a day (weighted
mean difference - 0.77 (95 % CI - 1.50, - 0.04), I 2= 80 %) (without an increase
in the number of illness episodes), and fewer numbers of days absent from day
care/school/work (SMD - 0.17 (95 % CI - 0.31, - 0.03), I 2= 67 %) in
participants who received a probiotic intervention than in those who had taken a
placebo"
-
Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified
fatty acid levels in Japanese hypertriacylglycerolemic subjects - Lipids
Health Dis. 2014 Feb 19;13(1):36 - "Lactobacillus
gasseri SBT2055 (LG2055) inhibits dietary fat absorption in rats and exerts
preventive effects on abdominal adiposity in rats and human ... non-esterified
fatty acid (NEFA) ... The consumption of probiotic LG2055 reduced postprandial
and fasting serum NEFA levels, suggesting its possible contribution to the
reduction of the risk for obesity and type 2 diabetes mellitus"
-
Synbiotic
supplementation in nonalcoholic fatty liver disease: a randomized, double-blind,
placebo-controlled pilot study - Am J Clin Nutr. 2014 Jan 8 -
"52 patients
with NAFLD were supplemented twice daily for 28 wk with either a synbiotic or a
placebo capsule ... Synbiotic supplementation in addition to lifestyle
modification is superior to lifestyle modification alone for the treatment of
NAFLD, at least partially through attenuation of inflammatory markers in the
body" - See prebiotic supplements at Amazon.com
and
probiotic products at Amazon.com.
-
Synbiotics - Wikipedia - "Synbiotics
refer to nutritional supplements combining probiotics and prebiotics
in a form of synergism, hence synbiotics"
-
Effect of
Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and
maintenance in obese men and women - Br J Nutr. 2013 Dec 3:1-13 -
"The present study investigated the impact of a
Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation on weight loss and
maintenance in obese men and women over 24 weeks ... The intention-to-treat
analysis showed that after the first 12 weeks and after 24 weeks, mean weight
loss was not significantly different between the LPR and placebo groups when all
the subjects were considered. However, a significant treatment × sex interaction
was observed. The mean weight loss in women in the LPR group was significantly
higher than that in women in the placebo group (P= 0.02) after the first 12
weeks, whereas it was similar in men in the two groups (P= 0.53). Women in the
LPR group continued to lose body weight and fat mass during the
weight-maintenance period, whereas opposite changes were observed in the placebo
group. Changes in body weight and fat mass during the weight-maintenance period
were similar in men in both the groups. LPR-induced weight loss in women was
associated not only with significant reductions in fat mass and circulating
leptin concentrations but also with the relative abundance of bacteria of the
Lachnospiraceae family in faeces. The present study shows that the Lactobacillus
rhamnosus CGMCC1.3724 formulation helps obese women to achieve sustainable
weight loss" - See
Garden of Life, Primal Defense at Amazon.com which includes Lactobacillus rhamnosus.
-
Probiotic
supplementation for respiratory and gastrointestinal illness symptoms in healthy
physically active individuals - Clin Nutr. 2013 Oct 10 -
"Four hundred and sixty five participants (241 males;
age 35 ± 12 y (mean ± SD) and 224 females; age 36 ± 12 y) were assigned to one
of three groups: Group 1 - Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04)
2.0 × 109colony forming units per day, CFU per day, Group 2 - Lactobacillus
acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 (NCFM & Bi-07)
5 × 109 CFU each per day) or Group 3 - placebo mixed in a drink ... The risk of
an upper respiratory illness episode was significantly lower in the Bl-04 group
(hazard ratio 0.73; 95% confidence interval 0.55-0.95; P = 0.022) compared to
placebo. There was no significant difference in illness risk between the NCFM &
Bi-07 group (hazard ratio 0.81; 0.62-1.08; P = 0.15) and the placebo group.
There was a 0.7 and 0.9 month delay in the median time to an illness episode in
the Bl-04 and NCFM & Bi-07 groups respectively compared to placebo (placebo 2.5
months; Bl-04 3.2 months; NCFM & Bi-07 3.4 months). There were insufficient GI
illness episodes for analysis" - See
Bifidobacterium animalis products at iHerb.
- Activia - Wikipedia,
the free encyclopedia - "Activia products thus
contain Bifidobacterium animalis DN 173,010, a proprietary strain of
Bifidobacterium, a probiotic which is marketed by Dannon under the trade
names Bifidus Regularis, Bifidus Actiregularis, Bifidus Digestivum and
Bifidobacterium Lactis" - See my yogurt recipe which is made with
Activia on my yogurt page.
-
Probiotics
determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters -
Mol Nutr Food Res. 2013 - "probiotic mix (Lactobacillus
acidophilus and Bifidobacterium animalis) ... Male Golden Syrian hamsters
developed hyperlipidemia after 21 weeks of fat diet. For the last 5 weeks of
experiment, ten HL were treated with the probiotic mix (HLP), ten received water
(HL). Ten animals received standard chow (N). Increase of plasma total
cholesterol (TC), triglycerides (TG), phospholipids (PL), oxidized LDL, glucose,
of 4-hydroxynonenal (4-HNE) in plasma, liver, and myocardium, and of intestinal
Niemann Pick C1 like 1 (NPC1L1) and microsomal TG transfer protein (MTTP)
expression was observed in HL versus N. The probiotic mix decreased plasma TC,
TG, PL, oxidized LDL, 4-HNE, and glucose levels and increased paraoxonase-1
activity, decreased NPC1L1 and MTTP protein expression compared to HL. In HLP
liver, a significant reduction of TC, TG, and fatty acids was observed. PL
increased and 4-HNE levels decreased in the liver and myocardium of HLP versus
HL"
-
Oral
Lactobacillus reuteri GMN-32 treatment reduces blood glucose concentrations and
promotes cardiac function in rats with streptozotocin-induced diabetes mellitus
- Br J Nutr. 2013 Sep 4:1-8 - "diabetic cardiomyopathy
(DC) ... In conclusion, the administration of L. reuteri GMN-32 probiotics can
regulate blood glucose levels, protect cardiomyocytes and prevent DC in DM rats"
- See
Garden of Life, Primal Defense at Amazon.com.
-
Effect of
probiotic fermented milk on blood pressure: a meta-analysis of randomised
controlled trials - Br J Nutr. 2013 Jul 3:1-7 -
"PubMed, Cochrane library and the ClinicalTrials.gov databases were searched up
to March 2012 to identify eligible studies ... probiotic fermented milk,
compared with placebo, produced a significant reduction of 3.10 mmHg (95 % CI -
4.64, - 1.56) in systolic BP and 1.09 mmHg (95 % CI - 2.11, - 0.06) in diastolic
BP. Subgroup analyses suggested a slightly greater effect on systolic BP in
hypertensive participants than in normotensive ones ( - 3.98 v. - 2.09 mmHg).
Analysis of trials conducted in Japan showed a greater reduction than those
conducted in European countries for both systolic BP ( - 6.12 v. - 2.08 mmHg)
and diastolic BP ( - 3.45 v. - 0.52 mmHg)"
-
Effects of
synbiotic food consumption on metabolic status of diabetic patients: A
double-blind randomized cross-over controlled clinical trial - Clin Nutr.
2013 Jun 7 - "This randomized double-blinded cross-over
controlled clinical trial was performed among 62 diabetic patients aged 35-70 y.
After a 2-wk run-in period, subjects were randomly assigned to consume either a
synbiotic (n = 62) or control food (n = 62) for 6 weeks ... The synbiotic food
consisted of a probiotic viable and heat-resistant Lactobacillus sporogenes (1 ×
107 CFU), 0.04 g inulin (HPX) as prebiotic with 0.38 g isomalt, 0.36 g sorbitol
and 0.05 g stevia as sweetener per 1 g. Control food (the same substance without
probiotic bacteria and prebiotic inulin) was packed in identical 9-gram
packages. Patients were asked to consume the synbiotic and control foods three
times a day ... In conclusion, consumption of a synbiotic food for 6 weeks among
diabetic patients had significant effects on serum insulin, hs-CRP, uric acid
and plasma total GSH levels" - Note: I not sure whether they are talking
about probiotic supplements added to the food or
something like yogurt. See
probiotic products at Amazon.com
and my yogurt recipe at the top of my Yogurt Page.
-
Effect of
Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults
in a randomised controlled trial - Br J Nutr. 2013 Apr 25:1-8 -
"Lactobacillus gasseri SBT2055 (LG2055) ... A
multi-centre, double-blind, parallel-group RCT was conducted using 210 healthy
Japanese adults with large visceral fat areas ... These findings demonstrate
that consumption of LG2055 at doses as low as the order of 108cfu/d exhibited a
significant lowering effect on abdominal adiposity, and suggest that constant
consumption might be needed to maintain the effect"
-
Lactobacilli versus
antibiotics to prevent urinary tract infections: a randomized, double-blind,
noninferiority trial in postmenopausal women - Ned Tijdschr Geneeskd.
2013;157(7):A5674 - "In postmenopausal women with
recurrent UTIs, L. rhamnosus GR-1 and L. reuteri RC-14 do not meet the
noninferiority criteria in the prevention of UTIs when compared with CTX.
However, unlike CTX, lactobacilli do not increase antibiotic resistance"
-
Attenuation
of post-myocardial infarction depression in rats by n-3 fatty acids or
probiotics starting after the onset of reperfusion - Br J Nutr. 2012 Oct
15:1-7 - "Proinflammatory cytokines play a central role
in depression-like behaviour and apoptosis in the limbic system after myocardial
infarction (MI). A PUFA n-3 diet or the combination of Lactobacillus helveticus
R0052 and Bifidobacterium longum R0175 probiotics, when given before the
ischaemic period, reduce circulating proinflammatory cytokines as well as
apoptosis in the limbic system ... These results indicate that a high-PUFA n-3
diet or the administration of probiotics, starting after the onset of
reperfusion, are beneficial to attenuate apoptosis in the limbic system and
post-MI depression in the rat" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com
and
probiotic products at Amazon.com.
-
Effect of
Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on
health-related quality of life in college students affected by upper respiratory
infections - Br J Nutr. 2012 Oct 1:1-9 - "College
students are susceptible to upper respiratory infections (URI) due to inadequate
sleep, stress and close living quarters. Certain probiotic strains modulate
immune function and may improve health-related quality of life (HRQL) during URI
... randomised to receive placebo (n 117) or probiotic-containing powder (daily
dose of minimum 1 billion colony-forming units of each Lactobacillus rhamnosus
LGG® (LGG®) and Bifidobacterium animalis ssp. lactis BB-12® (BB-12®); n 114) for
12 weeks ... The median duration of URI was significantly shorter by 2 d and
median severity score was significantly lower by 34 % with probiotics v. placebo
(P < 0.001), indicating a higher HRQL during URI. Number of missed work days was
not different between groups (P = 0.429); however, the probiotics group missed
significantly fewer school days (mean difference = 0.2 d) compared to the
placebo group (P = 0.002). LGG® and BB-12® may be beneficial among college
students with URI for mitigating decrements in HRQL"
-
Immunoprotective effects of oral intake of heat-killed Lactobacillus pentosus
strain b240 in elderly adults: a randomised, double-blind, placebo-controlled
trial - Br J Nutr. 2012 Sep 5:1-10 - "Oral intake of
Lactobacillus pentosus strain b240 (b240) has been shown to enhance the
secretion of salivary secretory IgA in elderly adults ... 300 eligible elderly
adults were randomly allocated to one of three groups, namely a placebo,
low-dose or high-dose b240 group. Participants in the low-dose and high-dose
b240 groups were given tablets containing 2 × 109 or 2 × 1010 cells,
respectively, of heat-killed b240, while those in the placebo group were given
tablets without b240. Each group consumed their respective tablets once daily
for 20 weeks ... The accumulated incidence rate of the common cold was 47.3,
34.8 and 29.0 % for the placebo, low-dose b240 and high-dose b240 groups,
respectively (P for trend = 0.012). Lower incidence rates were consistently
observed throughout the experimental period in the b240 groups (log-rank test, P
= 0.034). General health perception, as determined by the SF-36®,
dose-dependently increased in the b240 groups (P for trend = 0.016). In
conclusion, oral intake of b240 significantly reduced the incidence rate of the
common cold in elderly adults, indicating that b240 might be useful in improving
resistance against infection through mucosal immunity" - Note: I
calculate that as a 39% reduction in colds [(47.3 - 29)/47.3] = .39
-
Effect of
the consumption of a new symbiotic shake on glycemia and cholesterol levels in
elderly people with type 2 diabetes mellitus - Lipids Health Dis. 2012 Feb
22;11:29 - "A randomized, double-blind,
placebo-controlled study was conducted on twenty volunteers (ten for placebo
group and ten for symbiotic group), aged 50 to 60 years ... Over a total test
period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of
200 mL of a symbiotic shake containing 10(8) UFC/mL Lactobacillus acidophilus,
10(8) UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other
volunteers (the placebo group) drank daily the same amount of a shake that did
not contain any symbiotic bacteria ... The results of the symbiotic group showed
a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a
significant increase (P < 0.05) in HDL cholesterol and a significant reduction
(P < 0.05) in fasting glycemia. No significant changes were observed in the
placebo group"
-
Lactobacilli
vs Antibiotics to Prevent Urinary Tract Infections: A Randomized, Double-blind,
Noninferiority Trial in Postmenopausal Women - Arch Intern Med. 2012 May
14;172(9):704-12 - "Growing antibiotic resistance
warrants studying nonantibiotic prophylaxis for recurrent urinary tract
infections (UTIs). Use of lactobacilli appears to be promising ... Between
January 2005 and August 2007, we randomized 252 postmenopausal women with
recurrent UTIs taking part in a double-blind noninferiority trial to receive 12
months of prophylaxis with trimethoprim-sulfamethoxazole, 480 mg, once daily or
oral capsules containing 109 colony-forming units of Lactobacillus rhamnosus
GR-1 and Lactobacillus reuteri RC-14 twice daily ...The mean number of
symptomatic UTIs in the year preceding randomization was 7.0 in the
trimethoprim-sulfamethoxazole group and 6.8 in the lactobacilli group. In the
intention-to-treat analysis, after 12 months of prophylaxis, these numbers were
2.9 and 3.3, respectively. The between-treatment difference of 0.4 UTIs per year
(95% CI, -0.4 to 1.5) was outside our noninferiority margin. At least 1
symptomatic UTI occurred in 69.3% and 79.1% of the trimethoprim-sulfamethoxazole
and lactobacilli participants, respectively; median times to the first UTI were
6 and 3 months, respectively. After 1 month of trimethoprim-sulfamethoxazole
prophylaxis, resistance to trimethoprim-sulfamethoxazole, trimethoprim, and
amoxicillin had increased from approximately 20% to 40% to approximately 80% to
95% in E coli from the feces and urine of asymptomatic women and among E coli
causing a UTI. During the 3 months after trimethoprim-sulfamethoxazole
discontinuation, resistance levels gradually decreased. Resistance did not
increase during lactobacilli prophylaxis. CONCLUSIONS In postmenopausal women
with recurrent UTIs, L rhamnosus GR-1 and L reuteri RC-14 do not meet the
noninferiority criteria in the prevention of UTIs when compared with
trimethoprim-sulfamethoxazole. However, unlike trimethoprim-sulfamethoxazole,
lactobacilli do not increase antibiotic resistance" - See
lactobacillus products at iHerb.
-
Preoperative
Probiotics Decrease Postoperative Infectious Complications of Colorectal Cancer
- Am J Med Sci. 2011 Dec 23 - "The preoperative oral
bifid triple viable probiotics minimize the postoperative occurrence of
infectious complications, with possible mechanisms attributed to the maintenance
of the intestinal flora and restriction of bacterial translocation from the
intestine. It was representative of the enhancement of systemic/localized
immunity and concurrent attenuation of systemic stress response"
-
Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active
Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic
adults - Br J Nutr. 2011 Nov 9:1-9 - "Over the
intervention period, subjects consuming yoghurts containing microencapsulated L.
reuteri NCIMB 30242 attained significant reductions in LDL-cholesterol (LDL-C)
of 8.92 % (P = 0.016), total cholesterol (TC) of 4.81 % (P = 0.031) and
non-HDL-cholesterol (HDL-C) of 6.01 % (P = 0.029) over placebo, and a
significant absolute change in apoB-100 of - 0.19 mmol/l (P = 0.049). Serum
concentrations of TAG and HDL-C were unchanged over the course of the study.
Present results show that consumption of microencapsulated BSH-active L. reuteri
NCIMB 30242 yoghurt is efficacious and safe for lowering LDL-C, TC, apoB-100 and
non-HDL-C in hypercholesterolaemic subjects. The efficacy of microencapsulated
BSH-active L. reuteri NCIMB 30242 yoghurts appears to be superior to traditional
probiotic therapy and akin to that of other cholesterol-lowering ingredients"
-
Comparative
effects of six probiotic strains on immune function in vitro - Br J Nutr.
2011 Nov 7:1-12 - "The present study compared the
immunomodulatory properties of six probiotic strains of different species and
two genera in a human peripheral blood mononuclear cell (PBMC) model in vitro.
Live cells of lactobacilli (Lactobacillus casei Shirota, L. rhamnosus GG, L.
plantarum NCIMB 8826 and L. reuteri NCIMB 11951) and bifidobacteria
(Bifidobacterium longum SP 07/3 and B. bifidum MF 20/5) were individually
incubated with PBMC from seven healthy subjects for 24 h. Probiotic strains
increased the proportion of CD69+ on lymphocytes, T cells, T cell subsets and
natural killer (NK) cells, and increased the proportion of CD25+, mainly on
lymphocytes and NK cells. The effects on activation marker expression did not
appear to be strain specific. NK cell activity was significantly increased by
all six strains, without any significant difference between strains. Probiotic
strains increased production of IL-1β, IL-6, IL-10, TNF-α,
granulocyte-macrophage colony-stimulating factor and macrophage inflammatory
protein 1α to different extents, but had no effect on the production of IL-2,
IL-4, IL-5 or TNF-β. The cytokines that showed strain-specific modulation
included IL-10, interferon-γ, TNF-α, IL-12p70, IL-6 and monocyte chemotactic
protein-1. The Lactobacillus strains tended to promote T helper 1 cytokines,
whereas bifidobacterial strains tended to produce a more anti-inflammatory
profile. The results suggest that there was limited evidence of strain-specific
effects of probiotics with respect to T cell and NK cell activation or NK cell
activity, whereas production of some cytokines was differentially influenced by
probiotic strains"
-
Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates
allergen-induced airway inflammation in a mouse model of allergic asthma -
Br J Nutr. 2011 Oct 14:1-10 - "Our results showed that
oral administration of a high dose of L. gasseri (4 × 106 CFU) decreased airway
responsiveness to methacholine, attenuated the influx of inflammatory cells to
the airways and reduced the levels of TNF-α, thymus and activation-regulated
chemokine (TARC) and IL-17A in BAL fluids of Der p-sensitised and -challenged
mice. Moreover, L. gasseri decreased IL-17A production in transforming growth
factor-α and IL-6 stimulated splenocytes and cell numbers of IL-17 producing
alveolar macrophages in L. gasseri-treated mice as compared to non-treated, Der
p-sensitised and -challenged mice. In conclusion, oral administration with L.
gasseri can attenuate major characteristics of allergen-induced airway
inflammation and IL-17 pro-inflammatory immune response in a mouse model of
allergic asthma, which may have clinical implication in the preventive or
therapeutic potential in allergic asthma"
-
Oral
inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour
growth both in segmental orthotopic colon cancer and extra-intestinal tissue
- Br J Nutr. 2011 Sep 30:1-12 - "Modulation of the
cellular response by the administration of probiotic bacteria may be an
effective strategy for preventing or inhibiting tumour growth. We orally
pre-inoculated mice with probiotics Lactobacillus acidophilus NCFM (La) for 14
d. Subcutaneous dorsal-flank tumours and segmental orthotopic colon cancers were
implanted into mice using CT-26 murine colon adenocarcinoma cells. On day 28
after tumour initiation, the lamina propria of the colon, mesenteric lymph nodes
(MLN) and spleen were harvested and purified for flow cytometry and mRNA
analyses. We demonstrated that La pre-inoculation reduced tumour volume growth
by 50.3 %, compared with untreated mice at 28 d after tumour implants (2465.5
(sem 1290.4) v. 4950.9 (sem 1689.3) mm3, P < 0.001)"
-
Evaluation
of the immune benefits of two probiotic strains Bifidobacterium animalis ssp.
lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an
influenza vaccination model: a randomised, double-blind, placebo-controlled
study - Br J Nutr. 2011 Sep 7:1-9 - "The present
study investigated the ability of Bifidobacterium animalis ssp. lactis (BB-12®)
and Lactobacillus paracasei ssp. paracasei (L. casei 431®) to modulate the
immune system using a vaccination model in healthy subjects. A randomised,
double-blind, placebo-controlled, parallel-group study was conducted in 211
subjects (56 % females, mean age 33.2 (sd 13.1) years). Subjects consumed a
minimum of 109 colony-forming units of BB-12® (capsule) or L. casei 431® (dairy
drink) or a matching placebo once daily for 6 weeks. After 2 weeks, a seasonal
influenza vaccination was given. Plasma and saliva samples were collected at
baseline and after 6 weeks for the analysis of antibodies, cytokines and innate
immune parameters. Changes from baseline in vaccine-specific plasma IgG, IgG1
and IgG3 were significantly greater in both probiotic groups v. the
corresponding placebo group (L. casei 431®, P = 0.01 for IgG; P < 0.001 for
remaining comparisons). The number of subjects obtaining a substantial increase
in specific IgG (defined as ≥ 2-fold above baseline) was significantly greater
in both probiotic groups v. placebo (BB-12®, P < 0.001 for IgG, IgG1 and IgG3;
L. casei 431®, P < 0.001 for IgG1 and IgG3). Significantly greater mean fold
increases for vaccine-specific secretory IgA in saliva were observed in both
probiotic groups v. placebo (BB-12®, P = 0.017; L. casei 431®, P = 0.035).
Similar results were observed for total antibody concentrations. No differences
were found for plasma cytokines or innate immune parameters. Data herein show
that supplementation with BB-12® or L. casei 431® may be an effective means to
improve immune function by augmenting systemic and mucosal immune responses to
challenge"
-
Probiotics
and prebiotics in the management of irritable bowel syndrome: a review of recent
clinical trials and systematic reviews - Curr Opin Clin Nutr Metab Care.
2011 Sep 1 - "Most systematic reviews indicate that
probiotics have a beneficial impact on global IBS symptoms, abdominal pain and
flatulence. However, recent trials indicate that different probiotics can
improve, have no effect, or even worsen symptoms, confirming that benefits are
likely to be strain and symptom-specific. There are no recent clinical trials of
prebiotics in IBS, although previous studies indicate potential benefit at lower
doses ... Clearly, some probiotics have considerable potential in the management
of IBS; however, the benefits are likely to be strain-specific. Preliminary
studies suggest low doses of prebiotics may improve symptoms of IBS, although
further robust clinical trials are required"
-
Is
Bifidobacterium breve effective in the treatment of childhood constipation?
Results from a pilot study - Nutr J. 2011 Feb 23;10(1):19 -
"Probiotics are increasingly used in the treatment of
functional gastrointestinal disorders. Studies in constipated adults with a
Bifidus yoghurt (containing Bifidobacterium breve, Bifidobacterium bifidum and
Lactobacillus acidophilus) showed a significant increase in defecation frequency
... The defecation frequency per week significantly increased from 0.9 (0-2) at
baseline to 4.9 (0-21) in week 4 (p< 0.01). The mean stool consistency score
increased from 2.6 (2-4) at baseline to 3.5 (1-6) in week 4 (p = 0.03). The
number of faecal incontinence episodes per week significantly decreased from 9.0
(0-35) at baseline to 1.5 (0-7) in week 4 (p <0.01). Abdominal pain episodes per
week significantly decreased from 4.2 (0-7) at baseline to 1.9 (0-7) in week 4
(p = 0.01). No side effects occurred" - See
Bifidobacterium breve products at iHerb.
-
Fermented
milk containing Lactobacillus casei strain Shirota reduces incidence of hard or
lumpy stools in healthy population - Int J Food Sci Nutr. 2011 Feb 15 -
"Healthy subjects with Bristol Stool Form Scale (BS)
score < 3.0 were randomized to fermented milk treatment for 3 weeks or
non-intervention control. The primary endpoint was the proportion of subjects
that produced hard or lumpy stools (HLS) ≥ 25% of bowel movements (H-HLS).
Secondary endpoints included changes in BS score, constipation-related symptom
scores and stool parameters. Efficacy was analyzed in 39 subjects. After 3 weeks
of treatment the proportion of H-HLS subjects had significantly decreased from
73.7% to 36.8%, whereas in the control group the proportion had increased from
75.0% to 85.0% during the same period (P = 0.002). The BS score was
significantly improved after the treatment compared with the control (P <
0.001). In conclusion, daily consumption of fermented milk containing LcS
reduced the incidence of HLS" - See
Garden of Life, Primal Defense, HSO Probiotic Formula, 180 + 36 = 216 Caplets at
iHerb which includes the Lactobacillus casei strain.
-
Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis -
Allergy. 2011 Feb;66(2):170-177 - "The prevalence of
'frequent wheezing' and 'wheezing and/or noisy breathing apart from colds' was
significantly lower in the synbiotic than in the placebo group (13.9%vs 34.2%,
absolute risk reduction (ARR) -20.3%, 95% CI -39.2% to -1.5%, and 2.8%vs 30.8%,
ARR -28.0%, 95% CI -43.3% to -12.5%, respectively). Significantly less children
in the synbiotic than in the placebo group had started to use asthma medication
after baseline (5.6%vs 25.6%, ARR -20.1%, 95% CI -35.7% to -4.5%)" - See
synbiotic products at iHerb.
-
Assessment of psychotropic-like properties of a probiotic formulation (
Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and
human subjects - Br J Nutr. 2010 Oct 26:1-9 - "In
the preclinical study, rats were daily administered PF for 2 weeks and
subsequently tested in the conditioned defensive burying test, a screening model
for anti-anxiety agents. In the clinical trial, volunteers participated in a
double-blind, placebo-controlled, randomised parallel group study with PF
administered for 30 d and assessed with the Hopkins Symptom Checklist (HSCL-90),
the Hospital Anxiety and Depression Scale (HADS), the Perceived Stress Scale,
the Coping Checklist (CCL) and 24 h urinary free cortisol (UFC). Daily
subchronic administration of PF significantly reduced anxiety-like behaviour in
rats (P < 0.05) and alleviated psychological distress in volunteers, as measured
particularly by the HSCL-90 scale (global severity index, P < 0.05;
somatisation, P < 0.05; depression, P < 0.05;
and anger-hostility, P < 0.05), the HADS (HADS global score, P < 0.05; and
HADS-anxiety, P < 0.06), and by the CCL (problem solving, P < 0.05) and the UFC
level (P < 0.05). L. helveticus R0052 and B. longum R0175 taken in combination
display anxiolytic-like activity in rats and beneficial psychological effects in
healthy human volunteers" - Note, in case you missed it, it's saying that
it also reduced cortisol.
-
The colonic
microflora and probiotic therapy in health and disease - Curr Opin
Gastroenterol. 2010 Oct 1 - "Reciprocal signalling
between the immune system and the microbiota plays a pivotal role in linking
alterations in gut microbiota with risk of metabolic disease in the host,
notably insulin resistance, obesity, and chronic low-grade inflammation. Loss of
ancestral indigenous organisms consequent upon a modern lifestyle may contribute
to an increased frequency of various metabolic and immuno-allergic diseases. The
potential to address this underpins the science of pharmabiotics"
-
Prebiotic
effects: metabolic and health benefits - Br J Nutr. 2010 Aug;104(S2):S1-S63
- "Numerous experimental studies have reported reduction
in incidence of tumours and cancers after feeding specific food products with a
prebiotic effect. Some of these studies (including one human trial) have also
reported that, in such conditions, gut microbiota composition was modified
(especially due to increased concentration of bifidobacteria). Dietary intake of
particular food products with a prebiotic effect has been shown, especially in
adolescents, but also tentatively in postmenopausal women, to increase Ca
absorption as well as bone Ca accretion and bone mineral density. Recent data,
both from experimental models and from human studies, support the beneficial
effects of particular food products with prebiotic properties on energy
homaeostasis, satiety regulation and body weight gain. Together, with data in
obese animals and patients, these studies support the hypothesis that gut
microbiota composition (especially the number of bifidobacteria) may contribute
to modulate metabolic processes associated with syndrome X, especially obesity
and diabetes type 2. It is plausible, even though not exclusive, that these
effects are linked to the microbiota-induced changes and it is feasible to
conclude that their mechanisms fit into the prebiotic effect. However, the role
of such changes in these health benefits remains to be definitively proven. As a
result of the research activity that followed the publication of the prebiotic
concept 15 years ago, it has become clear that products that cause a selective
modification in the gut microbiota's composition and/or activity(ies) and thus
strengthens normobiosis could either induce beneficial physiological effects in
the colon and also in extra-intestinal compartments or contribute towards
reducing the risk of dysbiosis and associated intestinal and systemic
pathologies" - See
probiotics at Amazon.com.
-
Randomised, double-blind and placebo-controlled study using new probiotic
lactobacilli for strengthening the body immune defence against viral infections
- Eur J Nutr. 2010 Aug 28 - "The incidence of acquiring
one or more common cold episode was reduced from 67% in the control group to 55%
in the probiotic group (p < 0.05). Also, the number of days with common cold
symptoms were significantly (p < 0.05) reduced from 8.6 days in the control
group to 6.2 days, in the probiotic group, during the 12-week period. The total
symptom score was reduced during the study period from a mean of 44.4 for the
control group to 33.6 for the probiotic group. The reduction in pharyngeal
symptoms was significant (p < 0.05). In addition, the proliferation of B
lymphocytes was significantly counteracted in the probiotic group (p < 0.05) in
comparison with the control group"
-
Pilot study
of probiotic dietary supplementation for promoting healthy kidney function in
patients with chronic kidney disease - Adv Ther. 2010 Aug 16 -
"Oral ingestion of probiotics (90 billion colony forming
units [CFUs]/day) was well tolerated and safe during the entire trial period at
all sites. BUN levels decreased in 29 patients (63%, P<0.05), creatinine levels
decreased in 20 patients (43%, no statistical significance), and uric acid
levels decreased in 15 patients (33%, no statistical significance). Almost all
subjects expressed a perceived substantial overall improvement in QOL (86%,
P<0.05)"
-
The Use of
Probiotics in Healthy Volunteers With Evacuation Disorders and Hard Stools: A
Double-blind, Randomized, Placebo-controlled Study - J Clin Gastroenterol.
2010 Aug 6 - "Subjects treated with the mixed probiotic
strains L. plantarum LP01 and B. breve BR03 or B. animalis subsp. lactis BS01
reported a significant improvement in the number of weekly bowel movements and
in the main troubles associated with evacuations, particularly consistency of
feces and ease of expulsion. Discomfort items such as abdominal bloating and
anal itching, burning, or pain also registered a relevant improvement in the
active groups receiving probiotics"
-
Impact of maternal probiotic-supplemented dietary counselling on pregnancy
outcome and prenatal and postnatal growth: a double-blind, placebo-controlled
study - Br J Nutr. 2010 Jun;103(12):1792-9 -
"Firstly, probiotic intervention reduced the frequency of gestational diabetes
mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 %
(control); P = 0.003. Secondly, the safety of this approach was attested by
normal duration of pregnancies with no adverse events in mothers or children. No
significant differences in prenatal or postnatal growth rates among the study
groups were detected. Thirdly, distinctive effects of the two interventions were
detected; probiotic intervention reduced the risk of GDM and dietary
intervention diminished the risk of larger birth size in affected cases; P =
0.035 for birth weight and P = 0.028 for birth length. The results of the
present study show that probiotic-supplemented perinatal dietary counselling
could be a safe and cost-effective tool in addressing the metabolic epidemic. In
view of the fact that birth size is a risk marker for later obesity, the present
results are of significance for public health in demonstrating that this risk is
modifiable"
-
Clinical
evidence of skin benefits of a dietary supplement containing probiotic and
carotenoids on UV- induced damage - Br J Dermatol. 2010 Jun 9 -
"Lactobacillus johnsonii (La1) ... dietary supplement
(DS) combining La1 and nutritional doses of carotenoids ... A 10 week DS intake
prevented the UV-DL induced decrease in Langerhans cell density and the increase
in Factor XIIIa+ type I dermal dendrocytes while it reduced dermal inflammatory
cells. Clinical and instrumental MED rose by 20% and 19% respectively, and skin
colour was intensified, as shown by the increase in DeltaE parameter. The
efficacy of DS was confirmed by dermatologists and subjects in real conditions
of use. Conclusion: Nutritional supplementation combining a specific probiotic
(la1) and nutritional doses of carotenoids reduced early UV-induced skin damage
caused by simulated or natural sun exposure in a large panel of subjects
(n=139). Altogether, these results support the use of this nutritional
supplement for a global approach in photoprotection, in combination with a
sunscreen" - See
probiotics at Amazon.comand
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
-
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055)
in adults with obese tendencies in a randomized controlled trial - Eur J
Clin Nutr. 2010 Jun;64(6):636-43 - "fermented milk (FM)
... In the active FM group, abdominal visceral and subcutaneous fat areas
significantly (P<0.01) decreased from baseline by an average of 4.6% (mean
(confidence interval): -5.8 (-10.0, -1.7) cm(2)) and 3.3% (-7.4 (-11.6, -3.1)
cm(2)), respectively. Body weight and other measures also decreased
significantly (P<0.001) as follows: body weight, 1.4% (-1.1 (-1.5, -0.7) kg);
BMI, 1.5% (-0.4 (-0.5, -0.2) kg/m(2)); waist, 1.8% (-1.7 (-2.1, -1.4) cm); hip,
1.5% (-1.5 (-1.8, -1.1) cm). In the control group, by contrast, none of these
parameters decreased significantly. High-molecular weight adiponectin in serum
increased significantly (P<0.01) in the active and control groups by 12.7% (0.17
(0.07, 0.26) microg/ml) and 13.6% (0.23 (0.07, 0.38) microg/ml), respectively.
CONCLUSION: The probiotic LG2055 showed lowering effects on abdominal adiposity,
body weight and other measures, suggesting its beneficial influence on metabolic
disorders"
-
Reducing
the risk of infection in the elderly by dietary intake of yoghurt fermented
with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 - Br J Nutr.
2010 May 21:1-9 - "90 g yoghurt or drink 100 ml milk
once per d over an 8- or 12-week period. A meta-analysis of the results of
these two independent studies showed the risk of catching the common cold
was about 2.6 times lower (OR 0.39; P = 0.019) in the yoghurt group than in
the milk group and the increase of natural killer cell activity was
significantly higher in the yoghurt group than in the milk group" -
See
Yogourmet Electric Yogurt Maker at Amazon.com.
-
The influence of a probiotic milk drink on the development of gingivitis: a
pilot study - J Clin Periodontol. 2009 Oct;36(10):850-6 -
"Interproximal PI and papillary bleeding were not
different between the groups. In the test group, elastase activity and MMP-3
amount were significantly lower after the intake of the probiotic milk drink
(p<0.001 and 0.016). There was a significant increase of MPO activity in the
control group; both groups were different at the end of the study (p=0.014).
CONCLUSIONS: The data suggest a beneficial effect of the probiotic milk
drink on gingival inflammation"
-
Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration
in Children - PEDIATRICS Vol. 124 No. 2 August 2009, pp. e172-e179 -
"Relative to the placebo group, single and
combination probiotics reduced fever incidence by 53.0% (P = .0085) and
72.7% (P = .0009), coughing incidence by 41.4% (P = .027) and 62.1% (P =
.005), and rhinorrhea incidence by 28.2% (P = .68) and 58.8% (P = .03),
respectively. Fever, coughing, and rhinorrhea duration was decreased
significantly, relative to placebo, by 32%"
-
The effects of selected probiotic strains on the development of eczema (the
PandA study) - Allergy. 2009 Apr 9 - "This
particular combination of probiotic bacteria shows a preventive effect on
the incidence of eczema in high-risk children, which seems to be sustained
during the first 2 years of life. In addition to previous studies, the
preventive effect appears to be established within the first 3 months of
life"
-
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses
transsignaling by enhancing soluble gp130 production - Proc Natl Acad
Sci U S A. 2008 Sep 16 - "Results from in vivo
studies using a rat adjuvant-induced arthritis
model showed specific inhibition of IL-6 levels in the serum and joints of
EGCG-treated rats by 28% and 40%,
respectively, with concomitant amelioration of rat adjuvant-induced
arthritis. We also observed a marked decrease in membrane-bound gp130
protein expression in the joint homogenates of the EGCG-treated group. In
contrast, quantitative RT-PCR showed that the gp130/IL-6Ralpha mRNA ratio
increased by approximately 2-fold, suggesting a possible mechanism of sgp130
activation by EGCG. Gelatin zymography results showed EGCG inhibits
IL-6/soluble IL-6R-induced matrix metalloproteinase-2 activity in RA
synovial fibroblasts and in joint homogenates, possibly via up-regulation of
sgp130 synthesis. The results of these studies provide previously
undescribed evidence of IL-6 synthesis and transsignaling inhibition by EGCG
with a unique mechanism of sgp130 up-regulation, and thus hold promise as a
potential therapeutic agent for RA" - [Nutra
USA]
-
Oral delivery of Lactobacillus casei Shirota modifies allergen-induced
immune responses in allergic rhinitis - Clin Exp Allergy. 2008 May 28 -
"Lactobacillus casei Shirota (LcS) ... Volunteers
treated with LcS showed a significant reduction in levels of antigen-induced
IL-5, IL-6 and IFN-gamma production compared with volunteers supplemented
with placebo. Meanwhile, levels of specific IgG increased and IgE decreased
in the probiotic group"
-
Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of
Randomized, Controlled Trials - Dis Colon Rectum. 2008 May 9 -
"Pooling of eight trials for the outcome of clinical
improvement yielded a significant relative risk of 1.22 ... Probiotics may
improve symptoms of irritable bowel syndrome and can be used as supplement
to standard therapy"
-
Probiotic, as well as conventional yogurt, can enhance the stimulated
production of proinflammatory cytokines - J Hum Nutr Diet. 2007
Dec;20(6):590-598 - "Both conventional and probiotic
yogurt enhanced the stimulated production of pro-inflammatory cytokines"
-
Anti-ageing effect of a lactococcal strain: analysis using
senescence-accelerated mice - Br J Nutr. 2007 Jul 9;:1-9 -
"Oral administration of heat-killed Lactococcus
lactis subsp. cremoris H61 (strain H61) to aged SAMP6 mice was associated
with reduced bone density loss, a suppression of incidence of skin ulcers
and reduced hair loss, compared with controls"
-
Major depressive disorder: probiotics may be an adjuvant therapy
- Med Hypotheses. 2005;64(3):533-8 - "Stress, a
significant factor in MDD [major depressive disorder], is known to alter GI
microflora, lowering levels of lactobacilli and bifidobacterium. Research
suggests that bacteria in the GI tract can communicate with the central
nervous system, even in the absence of an immune response. Probiotics have
the potential to lower systemic inflammatory cytokines, decrease oxidative
stress, improve nutritional status, and correct SIBO. The effect of
probiotics on systemic inflammatory cytokines and oxidative stress may
ultimately lead to increased brain derived neurotrophic factor (BDNF). It is
our contention that probiotics may be an adjuvant to standard care in MDD"
-
Probiotics and prebiotics in the elderly - Postgrad Med J. 2004
Aug;80(946):447-51 - "Probiotics have been shown
clearly to boost immunity in the elderly"
-
Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in
subjects with colonized Helicobacter pylori - Am J Clin Nutr. 2004
Sep;80(3):737-41 - "Regular intake of yogurt
containing Bb12 and La5 effectively suppressed H. pylori infection in
humans"
-
Dietary factors protecting women from urinary tract infection - AJCN,
3/1/03 - "Frequent consumption of fresh juices,
especially berry juices, and fermented milk products containing probiotic
bacteria was associated with a decreased risk of recurrence of
UTI"
-
Ingested probiotics reduce nasal colonization with pathogenic bacteria
(Staphylococcus aureus, Streptococcus pneumoniae, and ß-hemolytic
streptococci) - AJCN, 3/1/03 - "The results
indicate that regular intake of probiotics can reduce PPB [potentially
pathogenic bacteria] in the upper respiratory tract. The results also
indicate a linkage of the lymphoid tissue between the gut and the upper
respiratory tract"
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