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The Effect of Curcumin
Supplementation on Weight Loss and Anthropometric Indices: An Umbrella Review
and Updated Meta-analyses of Randomized Controlled Trials - Am J Clin Nutr
2023 Mar 8 - "Curcumin supplementation may promote
weight loss and ameliorate obesity-related complications through its
anti-oxidative and anti-inflammatory properties ... Curcumin supplementation
significantly reduces anthropometric indices and bioavailability-enhanced
formulas are preferred. Augmenting curcumin supplement with lifestyle
modification should be an option for weight reduction" - See curcumin at Amazon.com.
-
Effects of curcumin/turmeric
supplementation on obesity indices and adipokines in adults: A grade-assessed
systematic review and dose-response meta-analysis of randomized controlled
trials - Phytother Res 2023 Mar 7 - "We found that
supplementation with curcumin/turmeric significantly reduced body weight (WMD:
-0.82 kg, 95% CI: -1.30, -0.35; p = 0.001), body mass index (WMD: -0.30 kg/m2 ,
95% CI: -0.53, -0.06, p = 0.013), waist circumference (WMD: -1.31 cm, 95% CI:
-1.94, -0.69, p < 0.001), body fat percentage (WMD: -0.88%, 95% CI: -1.51,
-0.25, p = 0.007), leptin (WMD = -4.46 ng/mL; 95% CI: -6.70, -2.21, p < 0.001),
and increased adiponectin (WMD = 2.48 μg/mL; 95% CI: 1.34, 3.62, p < 0.001).
Overall, our study shows that supplementation with curcumin/turmeric
significantly improves anthropometric indices of obesity and adiposity-related
adipokines (leptin and adiponectin). However, due to high between-studies
heterogeneity, we should interpret the results with caution" See
curcumin at Amazon.com.
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What's It Like to Take
Ozempic? A Doctor's Own Story - Medscape, 3/8/23 -
"With these new medications, I noticed that both my patients and I didn't
complain as much about nausea and vomiting, but I did experience stomach upset,
constipation, and acid reflux ... The appetite suppression is effective. It
slows down the emptying of the gut so I feel full longer. I've lost 30 lb with
these weekly injections and would like to lose another 20 lb. I follow a routine
of reasonable, portion-controlled eating and moderate exercise (30 minutes of
cardiovascular activity at least two to three times a week) ... Discontinuing
the medications may cause rebound weight gain, especially if I'm no longer
following a routine of healthy eating and/or moderate exercise. I deal with
minimal constipation by taking stool softeners, and I take antacids for acid
reflux."
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What the Ozempic Obsession Misses About Food and Health - Time, 2/21/23 -
"What we have learned (or rather, confirmed) through
this latest wave of weight loss drugs is that our society continues to
prioritize thinness over actual health. While we focus on our scales and our
waistlines as the North Star of wellness, we forget that we’re growing more
deficient in a number of critical nutrients that protect us from disease.
Ninety-five percent of the U.S. population is not meeting the recommended daily
intake of fiber. Another 75 percent is not getting enough magnesium. Globally,
1.1 billion people are zinc-deficient (symptoms of which can mirror those of
Alzheimer’s disease) due to inadequate dietary intake ... There’s also the fact
that Ozempic, like all drugs, can come with side effects. The most common,
according to the drug’s website, are: “nausea, vomiting, diarrhea, stomach
(abdominal) pain, and constipation.” Also mentioned is “Possible thyroid tumors,
including cancer.” One unmentioned but frequently reported side effect is
referred to as “Ozempic Face.” Also, to maintain the weight loss, you must stay
on Ozempic indefinitely—unless you used Ozempic to jumpstart healthier habits
around food, exercise, sleep, etc." - There was a segment on the news
where several endocrinologists were claiming that obesity is a disease. Maybe,
but I stand in line at the grocery store and see what they're buying and if I
ate the same thing, I'd have their weight and then some. I go to a restaurant
with them and it's 700 calorie lattes, 1000 calorie burgers and dessert. Portion
size!!!!
-
A
New Drug Switched Off My Appetite. What’s Left? - Wired, 2/3/23 -
"Mounjaro did what decades of struggle with managing
weight couldn’t. Welcome to the post-hunger age."
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Eating Potatoes Is Healthy
- Medscape, 2/1/23 - "Contrary to common belief,
potatoes do not have a negative effect on blood glucose levels and can actually
help people lose weight"
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Ozempic: Dieters Who Use Scarce Diabetes Drug Could Face Side Effects -
WebMD, 2/1/23 - "was pleasantly surprised to find
herself soon shedding pounds ... Then the side effects started — most
worryingly, a racing and palpitating heartbeat ... I could be laying down in bed
and my heart rate, like resting heart rate, would be 120 beats per minute ... It
was really having an effect on my heart rate, and that was really terrifying"
- Note: This is the drug that been on the news as a godsend to lose weight. The
weight loss version is under a different name and has a slightly higher dose. Be
careful. Go with the old fashioned way to lose weight.
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Size of Meals, Not Timing,
Linked to Weight Loss - Medscape, 1/20/23 - "the
total daily number of large and medium-sized meals was associated with weight
gain over time, while those who reported more smaller meals showed weight loss.
A daily increase of one large, medium, or small meal was associated with an
average annual weight change of 0.69 kg, 0.97 kg, and –0.30 kg, respectively"
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Effects of green tea
catechins and exercise training on body composition parameters - Int J Food
Sci Nutr 2022 Nov 29 - "The impact of phytochemicals, as
green tea catechins, on body composition measures has become a relevant topic as
ongoing epidemiological evidence suggests their potential role in weight loss.
Although catechins have been shown to modulate fat and energy metabolism,
clinical effects of green tea consumption still remain controversial. Given the
role played by physical exercise in weight management, it is important to
determine whether the association of catechins and exercise is able to improve
outcomes over and above the beneficial effects of exercise alone. Considering
that scientific findings on this topic are not entirely consistent, aim of the
present review was to assess the current scientific literature regarding the
interplay between green tea catechins and exercise in overweight and obese
populations. In particular, it was evaluated whether the addition of green tea
supplementation to exercise training was able to further improve the
exercise-induced changes in body composition parameters." - See
green tea extract at Amazon.com.
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Lutein ameliorates high-fat
diet-induced obesity, fatty liver, and glucose intolerance in C57BL/6J mice
- Phytother Res 2022 Sep 9 - "Obesity is a
multi-factorial metabolic syndrome that increases the risk of cardiovascular
diseases, diabetes, and cancer. We recently demonstrated the antiadipogenic
efficacy of lutein using a 3 T3-L1 cell culture model. This study aimed to
examine the antiobesity efficacy of lutein on high-fat (60% kcal fat)
diet-induced C57BL/6J obese mice model. Lutein (300 and 500 μM), Orlistat (30
mg/kg body weight - positive control), and its combination (orlistat, 15 mg/kg
body weight+lutein, 300 μM) were administered in high-fat diet (HFD)-fed mice
every other day for 24 weeks ... lutein administration and drug significantly
reduced epididymal and abdominal adipose tissue weights. Further, lutein reduced
the serum cholesterol and LDL-C concentration compared to the HFD group. The
HFD-induced elevation in the hepatic triglycerides and cholesterol levels were
significantly blocked by lutein and its combination with the drug. Similarly,
lutein and its drug combination efficiently lowered the HFD-mediated elevated
blood glucose levels. Lutein downregulated the expression of CEBP-α, PPAR-γ, and
FAS in the epididymal adipose tissue. Thus, supplementation of lutein may
control diet-induced obesity and associated complications in the human
population" - See lutein at Amazon.com.
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Lactobacillus reuteri J1
prevents obesity by altering the gut microbiota and regulating bile acid
metabolism in obese mice - Food Funct 2022 Jun 20 -
"Obesity is closely related to metabolic syndromes such as hyperlipidemia and
diabetes and has become a global public health problem. Probiotics are now used
as a treatment for obesity, but the mechanism by which probiotics treat obesity
remains unclear ... The results revealed that L. reuteri J1 prevented weight
gain, lowered fat mass and relieved dyslipidemia, and improved glucose
homeostasis and insulin sensitivity ... These results demonstrated that L.
reuteri J1 could treat obesity by inhibiting the FXR signaling pathways and
remodeling white adipose tissue, linked with UDCA and LCA which are affected by
intestinal microbiota" - See probiotic supplements at Amazon.com.
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Tirzepatide Powers
'Unprecedented' Weight Loss in SURMOUNT-1 - Medscape, 6/4/22 -
"And in an exploratory analysis, 40% of people who
received the highest-tested tirzepatide dose of 15 mg/week had at least a 25%
loss in baseline weight in the on-treatment analysis ... Looking at the data
another way, the average baseline weight of those in the trial was 104 kg (230
lb) at the start, and the average weight loss was between 35-52 lbs by 72 weeks
on treatment ... With tirzepatide, every prespecified cardiometabolic parameter
assessed in the trial showed clinically meaningful improvements, reported
Jastreboff, including an average 17% reduction in waist circumference in
patients on either of the highest two dosages, a 34% average drop in total fat
mass, an average 0.5 percentage point cut in baseline A1c at the highest two
dosages, substantial cuts in fasting plasma glucose and fasting insulin levels,
an average 28% drop in triglyceride levels, and an average systolic blood
pressure reduction of about 8 mm Hg that occurred within 24 weeks on treatment"
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Lactobacillus reuteri J1
prevents obesity by altering the gut microbiota and regulating bile acid
metabolism in obese mice - Food Funct 2022 Jun 1 -
"Probiotics are now used as a treatment for obesity, but the mechanism by which
probiotics treat obesity remains unclear. Herein, we investigated the effects of
Lactobacillus reuteri J1 ( L. reuteri J1) on obese mice with the strain being
administered at 1010, 109 and 108 CFU mL-1 and explored the possible underlying
molecular mechanism. The results revealed that L. reuteri J1 prevented weight
gain, lowered fat mass and relieved dyslipidemia, and improved glucose
homeostasis and insulin sensitivity. Moreover, the effect of obesity reversal
exhibited dose-dependence to some extent. More importantly, mice treated with L.
reuteri J1 altered the gut microbiota and bile acid (BA) composition. Analysis
of the gut microbiome showed that L. reuteri J1 increased the relative
abundances of Lactobacillus, Akkermansia and Clostridium, which strongly
correlated with ursodeoxycholic acid (UDCA) and lithocholic acid (LCA)" -
See probiotic supplements at Amazon.com.
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Early Metformin Minimizes
Antipsychotic-Induced Weight Gain - Medscape, 6/1/22 -
"The authors made a "strong" recommendation, for which
there was moderate-quality evidence, that for patients for whom a lifestyle
intervention is unacceptable or inappropriate, the use of metformin is an
"alternative first-line intervention" for antipsychotic drug-induced weight gain
... Likewise, as a strong recommendation with moderate-quality evidence, the
guidance encourages the use of metformin when nonpharmacologic intervention does
not seem to be effective ... The guideline also says it is preferable to start
metformin early for patients who gain more than 7% of their baseline weight
within the first month of antipsychotic treatment. It also endorses metformin
when weight gain is established ... The proposed starting dosage is 500 mg twice
per day with meals, with increments of 500 mg every 1 to 2 weeks until reaching
a target dose of 2000 mg/day ... The authors also recommend monitoring kidney
function annually, as well as vitamin B12 levels and individual tolerability and
compliance" - See
metformin at ReliableRX.
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Intestinal Flora Mediates
Antiobesity Effect of Rutin in High-Fat-Diet Mice - Mol Nutr Food Res 2022
May 26 - "Intestinal flora plays a critical role in the
development of diet-induced obesity and related metabolic complications. Rutin
is a natural flavonoid with potential prebiotic effects on regulating the
intestinal flora composition that is beneficial for host health ... Rutin can be
considered as a prebiotic agent for improving intestinal flora disorders and
obesity-associated metabolic perturbations in obese individuals" - See
rutin at Amazon.com.
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Ubiquitous nutrients suppress appetite and promote movement - Science Daily,
4/20/22 - "Of the 21 amino acids our bodies require,
there are 9 they are unable to produce on their own. They are called essential
amino acids. Because we must obtain these through our diet, they have far been
the focus of nutrition research. The other 12 amino acids are considered
non-essential. The body can produce them itself by altering other molecules ...
The researchers first fed mice either a mixture of various non-essential amino
acids or a sugar solution with the same amount of calories (control group). Both
groups of mice were then allowed to drink a milkshake, which they normally love.
While the control group drank copious amounts of it, the mice that had been fed
non-essential amino acids avoided theirs. Instead, they went around their
enclosure in search of alternative sustenance"
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The effects of
empagliflozin, dietary energy restriction, or both on appetite-regulatory gut
peptides in individuals with type 2 diabetes and overweight or obesity: the
SEESAW randomised, double-blind, placebo-controlled trial - Diabetes Obes
Metab 2022 Apr 19 - "68 adults (age 30-75 years) with
T2D (drug naïve or on metformin monotherapy; HbA1c 6.0-10.0% [42-86mmol/mol])
and BMI ≥25kg/m2 were randomised to: (1) placebo-only, (2) placebo-plus-diet,
(3) empagliflozin-only, or (4) empagliflozin-plus-diet for 24 weeks ... The mean
weight loss in each group at 24 weeks was 0.44, 1.91, 2.22, and 5.74 kg,
respectively" - See
empagliflozin inhousepharmacy.vu.
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Lipid metabolism disorders
and lipid mediator changes of mice in response to long-term exposure to high-fat
and high sucrose diets and ameliorative effects of mulberry leaves - Food
Funct 2022 Mar 31 - "Mulberry leaves exhibit anti-lipogenic
and lipid-lowering effects. However, the lipid biomarkers and underlying
mechanisms for the improvement of the action of mulberry leaves on obesity and
lipid metabolism disorders have not been sufficiently investigated yet ...
mulberry leaf water extract (MLWE) ... Our results showed that MLWE
supplementation not only decreased body weight gain, serum total triglycerides,
low-density lipoprotein cholesterol, alanine transaminase and aspartate
transaminase levels, but also increased the serum level of high-density
lipoprotein cholesterol. In addition, MLWE supplementation also ameliorated
hepatic steatosis and lipid accumulation" - See
mulberry leaf extract at Amazon.com.
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Low Vitamin D Link With
Obesity, Overweight Among Men - Medscape, 3/28/22 -
"Compared to men with normal weight, men with overweight were more likely to
have vitamin D inadequacy (adjusted odds ratio [OR], 1.2; P = .03), as were men
with obesity (adjusted OR, 1.4; P = .001), after adjusting for age, sex, place
of residence, education, physical activity, alcohol consumption, and smoking"
- See vitamin D at Amazon.com.
-
Oolong tea extract
alleviates weight gain in high-fat diet-induced obese rats by regulating lipid
metabolism and modulating gut microbiota - Food Funct 2022 Feb 18 -
"Oolong tea is semifermented, with its chemical
composition comprising features of green (unfermented) and black (fermented)
tea. Although green tea has anti-obesity properties, studies on the anti-obesity
ability of oolong tea are still scarce. In this study, we analyzed the chemical
composition of oolong tea extract (OTE) and investigated the effects of OTE on
high-fat diet-induced obese rats. OTE contained more
(-)-epigallocatechin-3-gallate, (-)-epigallocatechin, and
(-)-gallocatechin-3-gallate than theaflavins and theasinensins. Rats fed with a
high-fat diet (HFD) and treated with 0.5% OTE exhibited significantly reduced
body weight and visceral fat weight compared with the HFD-only group. OTE also
decreased adipocyte size, lipogenesis-related protein sterol regulatory
element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) protein
expression and increased thermogenesis-related protein peroxisome proliferator-activated
receptor gamma coactivator 1-alpha (PGC1α) and uncoupling protein 1 (UCP1)
protein expression in epididymal adipose tissue compared with the HFD group.
Moreover, the OTE groups had a significantly higher abundance of Candidatus
arthromitus and Hydrogenoanaerobacterium and a lower abundance of Ruminococcus1,
Oscillibacter, and Odoribacter compared with the HFD group. All these results
show that OTE can alleviate weight gain by regulating lipid metabolism and
modulating the distribution of the gut microbiota to decrease lipid accumulation
in adipose tissue" - See oolong
tea at Amazon.com.
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My Journey With
Intermittent Fasting: What Worked, What Proved Challenging - Medscape,
1/21/22 - "I chose the 16:8 regimen, believing it to be
best for a nurse working from home. I fast from 8 PM at night until noon the
following day. All food intake is restricted to the hours between noon and 8 PM.
Although this method has been less effective in studies of weight loss than the
other two, this may have more to do with a lack of guidance regarding caloric
intake than with the method of fasting. I have a colleague who faithfully
followed the time-restricted method, but he also ate healthfully during the
hours of food intake. He exercised during the morning and allowed himself light
meals, carefully counting calories during the hours he was allowed to eat. He
kept to a regimen of 1200 calories per day ... At the conclusion of 6 weeks, he
had lost 22 pounds and gained an immense amount of energy. He reported improved
sleep and reduced body aches and pains. This follows what researchers have
observed regarding the benefits of intermittent fasting ... The human body was
designed to go for prolonged periods without food intake. Our ancestors spent
hours hunting for food, often going for extended intervals without nutrition.
During periods of fasting, the body can jump-start mechanisms related to glucose
consumption, healing, and restoration. Human trials have demonstrated the
positive effects of intermittent fasting, which include improvement in chronic
health conditions such as diabetes, heart disease, obesity, neurologic disease,
and even cancer."
-
Groundbreaking study links grandparents' smoking to your body fat - Hill,
1/21/22 - "It’s potentially one of the first pieces
of evidence that human exposure to substances can be passed on to descendants,
though researchers have said much more work is needed to understand how that may
happen"
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Effect of Standardized
Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat
Reduction in Overweight or Obese Humans: A Randomized Double-Blind
Placebo-Controlled Study - Nutrients 2022, 14(1), 208 -
"A total of 93 healthy overweight or obese males and
females, aged 19–65 years, with body mass indexes (BMIs) ≥ 25 and <32 kg/m2,
were recruited and received either an oral administration of 600 mg of WHS, or
placebo tablets for 12 weeks. Daily supplementation with WHS decreased body
weights, body fat masses, and BMIs compared with the placebo-treated group. The
hip circumferences, visceral fat areas, abdominal fat areas, and
visceral-to-subcutaneous ratios decreased after WHS supplementation. No
significant side effects were observed during or after the 12 weeks of WHS
intake. In conclusion, WHS, which has beneficial effects on body weight and body
fat reduction, could be a promising antiobesity supplement that does not produce
any side effects" - [Nutra USA] - See
hydrangea supplements at Amazon.com.
-
Mulberry leaf
polysaccharides ameliorate obesity through activation of brown adipose tissue
and modulation of the gut microbiota in high-fat diet fed mice -
Food Funct 2021 Dec 24 - "Improving energy homeostasis
and the gut microbiota is a promising strategy to improve obesity and related
metabolic disorders. Mulberry leaf is one of the traditional Chinese medicines
and functional diets. In this work, a mouse model induced by high-fat diet (HFD)
was used to reveal the role of mulberry leaf polysaccharides (MLP). It was found
that MLP had a significant effect in limiting body weight gain (reduced by
19.95%, 35.47% and 52.46%, respectively), ameliorating hepatic steatosis and
regulating lipid metabolism in HFD induced obese mice (P <
0.05). RT-PCR and western blot analysis suggested that these metabolic
improvements were mediated by inducing the development of brown-like adipocytes
in inguinal white adipose tissue and enhancing brown adipose tissue activity.
Besides, 16S rRNA sequencing results led to the inference that MLP could
mitigate the composition and function of the gut microbiota. Together, these
findings indicated that MLP possess great potential as a diet supplement or
medication for obesity" - See mulberry leaf extract
at Amazon.com.
-
Total dairy consumption in
relation to overweight and obesity in children and adolescents: A systematic
review and meta-analysis - Obes Rev 2021 Dec 8 -
"results showed an inverse association between total dairy consumption and
obesity prevalence (OR (95% CI): 0.66 (0.48-0.91). No significant associations
were found between milk or yogurt and obesity prevalence risk. Regarding
prospective studies, total milk consumption was positively associated with
overweight prevalence (OR (95% CI): 1.13 (1.01-1.26)) and incidence (RR (95%CI):
1.17 (1.01-1.35)) risk. Evidence from pooled analysis of cross-sectional studies
suggested an inverse association between total dairy consumption and obesity"
-
Dietary flavonoid kaempferol
reduces obesity-associated hypothalamic microglia activation and promotes body
weight loss in mice with obesity - Nutr Neurosci 2021 Dec 14 -
"Energy balance (EB) is critically regulated by the
hypothalamic arcuate nucleus (ARC) by promoting appetite or anorectic actions.
Hypothalamic inflammation, driven by high activation of the microglia, has been
reported as a key mechanism involved in the development of diet-induced obesity.
Kaempferol (KF), a flavonoid-type polyphenol present in a large number of fruits
and vegetables, was shown to regulate both energy metabolism and inflammation
... These findings suggest that KF might fight obesity by regulating central
processes related to EB regulation and hypothalamic inflammation" - See
kaempferol at Amazom.com.
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Effectiveness of
testosterone replacement in men with obesity: a systematic review and
meta-analysis - Eur J Endocrinol 2021 Nov 1 - "A
total of 16 randomized controlled trials were included. With moderate certainty
of the evidence, no difference was found between TRT and placebo regarding total
adverse events, TRT led to a 2-kg lean body mass gain and slightly improved
low-density lipoprotein (LDL), without effects on the blood pressure. Due to
imprecision/heterogeneity, effects in cardiovascular events (relative risk 0.52,
95% CI 0.26 to 1.05, 7 trials, 583 participants), high-density lipoprotein,
hematocrit, prostate-specific antigen, HbA1c, and quality of life were unclear.
TRT was effective for waist circumference and body mass index; however, large
between-study heterogeneity was found, with 95% prediction intervals crossing
the null effect line. Meta-regression revealed that the average age of
participants was a significant modifier for both outcomes"
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Quantifying the relationship
between dapagliflozin and loss of weight in type 1 diabetes mellitus patients
- J Clin Pharm Ther 2021 Nov 9 - "Dapagliflozin was the
first oral treatment approved in type 1 diabetes mellitus (T1DM) patients,
simultaneously improving body weight ... Five dapagliflozin dosage groups, two
of them were 5 mg/day and three of them were 10 mg/day, 1612 T1DM patients were
analysed with maximal effect (Emax ) model, and evaluation index was change rate
of body weight from baseline value ... In these T1DM patients, dosages were not
incorporated into model, indicating no significant dose-response relationship
between 5 and 10 mg/day affecting loss of weight. Emax and the treatment
duration to reach half of the maximal effects (ET50 ) of dapagliflozin
influencing loss of weight in T1DM patients were -4.9% and 10.4 weeks, and the
duration to achieve 25%, 50%, 75%, and 80% (plateau) of Emax were 3.5, 10.4,
31.2, and 41.6 week ... To achieve the plateau period in loss of weight, 5
mg/day dapagliflozin was required for at least 41.6 weeks" - See
dapagliflozin at reliablerxpharmacy.com.
-
Curcuma longa extract
improves serum inflammatory markers and mental health in healthy participants
who are overweight: a randomized, double-blind, placebo-controlled trial -
Nutr J 2021 Nov 13 - "We performed a randomized,
double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years
with overweight. Participants took two capsules containing
CLE (CLE group, n =
45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and
serum inflammatory markers were measured ... After the intervention, the CLE
group had a significantly lower body weight (p < 0.05) and body mass index (p <
0.05) than the placebo group and significantly lower serum levels of C-reactive
protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE
group showed significant improvement of the MOS SF-36 mental health score (p <
0.05) and POMS anger-hostility score" - See
curcumin at Amazon.com.
-
Rutin promotes white adipose
tissue "browning" and brown adipose tissue activation partially through the
calmodulin-dependent protein kinase kinase β/AMP-activated protein kinase
pathway - Endocr J 2021 Oct 29 - "Promoting white
adipose tissue (WAT) "browning" and brown adipose tissue (BAT) activation could
contribute to increasing energy expenditure ... Male C57BL/6 mice (n = 6) were
fed a high-fat diet (HFD) for 12 weeks with/out rutin. In HFD-fed mice, rutin
treatment significantly inhibited weight gain, improved the metabolic profile of
plasma samples, decreased the weights of epididymal WAT (eWAT), inguina WAT (iWAT),
and liver, and adipocyte size. Furthermore, rutin also increased the expression
of uncoupling protein 1 (Ucp-1) and other thermogenic markers in the WAT and
BAT. In 3T3-L1 cells, rutin effectively reduced the formation of lipid droplets,
stimulated the expression of thermogenic markers, and reduced the expression of
adipogenic genes. Additionally, rutin markedly upregulated the AMP-activated
protein kinase (AMPK) pathway, and these effects were diminished by treatment
with the AMPK inhibitor compound C (CC). Pretreatment with the calmodulin-dependent
protein kinase kinase β (CaMKKβ) inhibitor STO-609 blocked the induction of
thermogenic markers in 3T3-L1 cells by rutin. Our results indicated that rutin
increased energy consumption, induced WAT "browning" and BAT activation, and
thus was a promising target for the development of new therapeutic approaches to
improve adipose tissue energy metabolism" - See
rutin at Amazon.com and
rutin at iHerb.com.
-
Lutein supplementation combined with a low-calorie diet in middle-aged obese
individuals: effects on anthropometric indices, body composition and metabolic
parameters - Br J Nutr 2021 Oct 14 - "After 10
weeks, body weight and waist circumference significantly decreased in both
groups, although between-group differences were not significant. There was more
of a decrease in the percentage of body fat in the lutein group v. the placebo
group. Moreover, the placebo group experienced a significant reduction in
fat-free mass (FFM), whereas the lutein group preserved FFM during calorie
restriction, although the between-group difference did not reach statistical
significance. Visceral fat and serum levels of total cholesterol (TC) and
LDL-cholesterol were significantly decreased only in the lutein group, with a
statistically significant difference between the two arms only for TC" -
[Nutra
USA] - See lutein at Amazon.com.
-
Gut
microbiota influences the ability to lose weight - Science Daily, 9/13/21 -
"The researchers focused on 48 individuals who lost more
than 1% of their body weight per month over a 6 to 12 month period and 57
individuals who did not lose any weight and had a stable body mass index (BMI)
over the same period. The researchers relied on metagenomics, the study of
genetic material recovered from blood and stool samples. The individuals
analyzed blood metabolites, blood proteins, clinical labs, dietary
questionnaires and gut bacteria in the two groups ... After controlling for age,
sex and baseline BMI, the researchers identified 31 baseline stool metagenomic
functional features that were associated with weight loss responses. These
included complex polysaccharide and protein degradation genes, stress-response
genes, respiration-related genes, cell wall synthesis genes and gut bacterial
replication rates. A major finding was that the ability of the gut microbiome to
break down starches was increased in people who did not lose weight. Another key
finding was that genes that help bacteria grow faster, multiply, replicate and
assemble cell walls were increased in people who lost more weight ... Research
has already shown that if you change your diet, you can alter the composition of
bacteria in your gut. According to Dr. Diener, if someone has a composition of
gut bacterial genes that confers resistance to weight loss, then perhaps you can
alter their diet to shift to a composition that would help them lose weight"
- See probiotic supplements at Amazon.com
and
iHerb.
-
Beneficial effects of a combination of Clostridium cochlearium and Lactobacillus
acidophilus on body weight gain, insulin sensitivity and gut microbiota in
high-fat diet induced obese mice Nutrition, 4 Aug 21 -
"Species L. acidophilus and butyrate producer C.
cochlearium have been shown potential anti-obesity effects. We hypothesized that
the combination of C. cochlearium and L. acidophilus (CC-LA) has beneficial
effects on body weight control and glucose homeostasis in high-fat diet induced
obese (DIO) mice ... thirty-six 6-week-old male C57BL/6 mice were randomly
assigned to three groups (n = 12). The experimental group (CC-LA) was
administered with CC-LA mixture and fed ad libitum with high-fat diet. High-fat
diet (HF) control and low-fat diet (LF) control groups were treated with the
same dose of sterile water as CC-LA group. After 17 weeks of dietary
intervention, the CC-LA group showed 17% less body weight gain than the HF group
did ... This study provided evidence that the CC-LA combination reduced obesity
and improved glucose metabolism in high fat diet treated DIO mice, potentially
mediated by the modulation of gut microbiota" - [Nutra
USA] - See
probiotic supplements at Amazon.com
and
iHerb.
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Capsaicin and Its Effects on
Body Weight - J Am Coll Nutr 2021 Aug 12 -
"Capsaicin is a bioactive compound found in the fruits (i.e., peppers) of the
plant genus Capsicum, which is widely used in many cultures. Besides many health
effects of this compound, it can also be effective in body weight control
through various mechanisms such as regulating lipolysis in adipocytes,
increasing the feeling of satiety, stimulating energy expenditure, and reducing
energy intake ... Capsaicin can decrease hunger through hormones in the
gastrointestinal tract ... Capsaicin can increase energy expenditure through
brown adipose tissue ... Capsaicin can increase lipolysis in white adipose
tissue" - See capsicum at Amazon.com and
iHerb.
-
Ginsenoside F2 Suppresses
Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway - J
Agric Food Chem 2021 Aug 3 - "Ginsenoside F2 (GF2) is a
protopanaxdiol saponin from Panax ginseng leaves and possesses many potential
pharmacological properties. GF2 may prevent obesity by directly binding to the
peroxisome proliferator-activated receptor-γ (PPARγ) and inhibiting adipocyte
differentiation ... GF2 suppressed adipogenesis and obesity by regulating the
expression of adipokines and activating the AMPK pathway. Hence, the findings
suggest that GF2 may have potential therapeutic implications to treat obesity"
- See
Panax ginseng
at Amazon.com and
iHerb.
-
Effects of 1-year Treatment
with Canagliflozin on Body Composition and Total Body Water in Patients with
Type 2 Diabetes - Diabetes Obes Metab 2021 Aug 2 -
"107 patients with type 2 diabetes were treated with canagliflozin 100 mg, as
add-on therapy, for 12 months ... plasma volume (PV) ... Body weight showed a
significant decrease from 1 month to 12 months of treatment with canagliflozin,
with a higher rate of decrease in body fat in body composition. A significant
decrease in mineral mass was also observed, but its rate was low. Following
treatment with canagliflozin, changes in total body water did not affect
intracellular water, and a significant decrease in extracellular water,
including plasma components, was observed early and was sustained up to 12
months. Protein mass, a component of muscle mass, was not affected, with only a
slight decrease in water volume observed ... Canagliflozin decreased
extracellular fluid and PV in addition to decreasing fat in the body via calorie
loss resulting from urinary glucose excretion. This study suggested that SGLT2
inhibitors might reduce body weight by regulating fat mass or water distribution
in the body and might have cardiac and renal protective effects by resetting the
homeostasis of fluid balance" - See
canagliflozin at ReliableRXPharmacy.
-
The
Effects of Limosilactobacillus reuteri LR-99 Supplementation on Body Mass Index,
Social Communication, Fine Motor Function, and Gut Microbiome Composition in
Individuals with Prader–Willi Syndrome: a Randomized Double-Blinded
Placebo-Controlled Trial - Probiotics Antimicrob Proteins 2021 Jun 11 -
"Prader-Willi
syndrome (PWS) is a rare genetic disorder associated with developmental delay,
obesity, and neuropsychiatric comorbidities. Limosilactobacillus reuteri
(Lactobacillus reuteri, Lact. reuteri) has demonstrated anti-obesity and
anti-inflammatory effects in previous studies. In the present study, we aim to
evaluate the effects of Lact. reuteri supplementation on body mass index (BMI),
social behaviors, and gut microbiota in individuals with PWS ... Participants
were randomly assigned to either receive daily Lact. reuteri LR-99 probiotic (6
× 1010 colony forming units) or a placebo sachet ... We found a significant
reduction in BMI for the probiotic group at both 6 weeks and 12 weeks relative
to the baseline (P < 0.05). Furthermore, we observed a significant improvement
in social communication and interaction, fine motor function, and total ASQ-3
score in the probiotics group compared to the placebo group (P < 0.05). Altered
gut microbiota was observed in the probiotic group to favor weight loss and
improve gut health. The findings suggest a novel therapeutic potential for Lact.
reuteri LR-99 probiotic to modulate BMI, social behaviors, and gut microbiota in
Prader-Willi syndrome patients, although further investigation is warranted" -
[Nutra USA] - See
Limosilactobacillus reuteri at Amazon.com.
-
Common
weight-loss drug successfully targets fat that can endanger heart health -
Science Daily, 8/4/21 - "The 185 study participants were
given a once-daily injection of liraglutide over 40 weeks of treatment. The
relative effects of liraglutide on fat reduction were two-fold greater in the
abdominal tissues and six-fold greater in the liver than seen on overall body
weight. The treatment effect was consistent across race/ethnicity and BMI
categories, and among those with or without baseline prediabetes. Liraglutide
also reduced fasting blood glucose and inflammation in this trial population
without diabetes, the majority of whom had normal blood sugar levels at
baseline."
-
FDA approves new obesity drug for long-term weight management - CBS, 6/21/21
- "In clinical trials, patients receiving the weekly
injection had an average weight loss of 15% and steadily lost weight over the
16-month study period. Importantly, these results are close to those for
patients who have bariatric surgery, and they are far better than those seen
from other weight loss drugs currently on the market ... Novo Nordisk’s obesity
drug Wegovy (semaglutide) is the first approved drug for chronic weight
management in adults with general obesity or overweight with at least one
weight-related condition, such as high blood pressure, type 2 diabetes, or high
cholesterol, since 2014 ... Wegovy is a synthesized version of a gut hormone
that curbs appetite. It is to be injected under the skin once-weekly"
-
The Probiotic Strain H. alvei
HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric
Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind
Placebo-Controlled Study - Nutrients 2021 -
"Subjects of the HA group received two capsules per day providing 100 billion
bacteria per day and subjects in the Placebo (P) group received two placebo
capsules ... A 12-week treatment with the probiotic strain H. alvei HA4597®
significantly improves weight loss, feeling of fullness and reduction of hip
circumference in overweight subjects following moderate hypocaloric diet. These
data support the use of H. alvei HA4597® in the global management of excess
weight" - [Nutra
USA] - Note: Here's the
targedys.com website. I don't see where it's for sale anywhere.
See probiotic supplements at Amazon.com.
-
Mulberry leaf activates
brown adipose tissue and induces browning of inguinal white adipose tissue in
type 2 diabetic rats through regulating AMPK signaling pathway - Br J Nutr
2021 May 11 - "Activation of brown adipocytes and
browning of white adipocytes are considered as a promising molecular target for
T2DM treatment. Mulberry leaf, a traditional Chinese medicine, has been
demonstrated to have multi-biological activities, including anti-diabetic and
anti-inflammatory effects. Our experiment results showed that mulberry leaf
significantly alleviated the disorder of glucose and lipid metabolism in T2DM
rats including reducing body weight (BW) gain, Lee's index, food intake,
inguinal white adipose tissue (IWAT) accumulation, blood lipid fasting insulin
level and fasting blood glucose level, increasing the ratios of brown adipose
tissue (BAT) mass to BW, and improving insulin sensitivity and liver function.
In addition, mulberry leaf induced browning of IWAT by enhancing the expressions
of brown-mark genes as well as beige-specific genes, including uncoupling
protein-1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1
alpha (PGC-1α), peroxisome proliferator-activated receptor alpha (PPARα),
PRD1-BF-1-RIZ1 homologous domain containing protein 16 (PRDM16), cell death
inducing DFFA like effector A (Cidea), CD137 and transmembrane protein 26
(TMEM26). Mulberry leaf also activated BAT by increasing the expressions of
brown-mark genes including UCP1, PGC-1α, PPARα, PRDM16 and Cidea. Moreover,
mulberry leaf enhanced the expression of nuclear respiratory factor 1 (NRF-1)
and mitochondrial transcription factor A (TFAM) genes that are responsible for
mitochondrial biogenesis in IWAT and BAT. Importantly, mulberry leaf also
increased the expression of UCP1 and carnitine palmitoyl transferase 1 (CPT1)
protein in both IWAT and BAT via a mechanism involving Adenosine 5'-monophosphate
(AMP)-activated protein kinase (AMPK) and PGC-1α pathway. In conclusion, our
findings identify the role of mulberry leaf in inducing adipose browning,
indicating that mulberry leaf may be used as a candidate browning agent for the
treatment of T2DM" - See
Mulberry leaf extract.
-
Mendelian Randomization
Analysis Reveals Causal Effects of the Human Gut Microbiota on Abdominal Obesity
- J Nutr 2021 Mar 24 - "trunk fat mass (TFM) ... Our
findings provided evidence of a causal association between gut microbiota and
TFM in UK adults and identified specific bacteria taxa that may regulate the fat
metabolism, thus offering new direction for the treatment of obesity" -
See probiotic supplements at Amazon.com.
-
Probiotics as a
Complementary Therapy for Management of Obesity: A Systematic Review - Evid
Based Complement Alternat Med 2021 Jan 22 - "It seems
that the probiotic products could have beneficial effects as an adjunct therapy
for care and management of obesity when used in high dose. However, due to
heterogeneity of included studies, it is required to confirm our results by more
meta-analyses of clinical trials" - See
probiotic supplements at Amazon.com.
-
FDA Approves Liraglutide
for Adolescents With Obesity - Medscape, 12/11/20 -
"liraglutide for 56 weeks cut BMI by 5% in 43% of patients, and by 10% in 26%,
compared with respective rates of 19% and 8% among those in the placebo-control
arm"
-
The Beneficial Effects of
Red Sun-Dried Capsicum annuum L. cv Senise Extract with Antioxidant Properties
in Experimental Obesity are Associated with Modulation of the Intestinal
Microbiota - Mol Nutr Food Res 2020 Dec 10 - "Mice
fed a high fat diet (HFD) were orally treated with an extract from these peppers
(CAE) (1, 10 and 25 mg/kg/day). It promoted weight loss and improved plasma
markers related to glucose and lipid metabolisms. CAE also ameliorated
obesity-associated systemic inflammation reducing the expression of
pro-inflammatory cytokines in adipose and hepatic tissues and improving the
expression of different markers involved in the gut epithelial barrier function.
These effects were associated with a modulation of the intestinal microbiome,
which appears altered" - See
capsicum at Amazon.com and
iHerb.
-
Non-Viable Lactobacillus
johnsonii JNU3402 Protects against Diet-Induced Obesity - Foods, 19 Oct 20 -
"In this study, the role of non-viable Lactobacillus
johnsonii JNU3402 (NV-LJ3402) in diet-induced obesity was investigated in mice
fed a high-fat diet (HFD). To determine whether NV-LJ3402 exhibits a protective
effect against diet-induced obesity, 7-week-old male C57BL/6J mice were fed a
normal diet, an HFD, or an HFD with NV-LJ3402 for 14 weeks. NV-LJ3402
administration was associated with a significant reduction in body weight gain
and in liver, epididymal, and inguinal white adipose tissue (WAT) and brown
adipose tissue weight in HFD-fed mice. Concomitantly, NV-LJ3402 administration
to HFD-fed mice also decreased the triglyceride levels in the plasma and
metabolic tissues and slightly improved insulin resistance. Furthermore,
NV-LJ3402 enhanced gene programming for energy dissipation in the WATs of
HFD-fed mice as well as in 3T3-L1 adipocytes with increased peroxisome
proliferator-activated receptor-γ (PPARγ) transcriptional activity, suggesting
that the PPARγ pathway plays a key role in mediating the anti-obesity effect of
NV-LJ3402 in HFD-fed mice. Furthermore, NV-LJ3402 administration in HFD-fed mice
enhanced mitochondrial levels and function in WATs and also increased the body
temperature upon cold exposure. Together, these results suggest that NV-LJ3402
could be safely used to develop dairy products that ameliorate diet-induced
obesity and hyperlipidemia" - [Nutra
USA] - See Lactobacillus johnsonii at
Amazon.com.
-
Alternate-day fasting,
obesity, and metabolic syndrome - Metabolism 2020 Aug 7 -
"Alternate-day fasting (ADF) is related to weight
reduction, lowered risks of weight regain, and relative lean body mass
preservation compared to continuous energy restriction ... We observed
significant effects of ADF for BMI (WMD -0.73 kg/m2, 95% CI -1.13 to -0.34), FM
(WMD -1.27 kg, 95% CI -2.09 to -0.46), and total cholesterol (WMD -8.14 mg/dL,
95% CI -14.59 to -1.69). Subgroup analyses indicated that significant
intervention effects were observed for BMI, BW, FM, and total cholesterol when
compared to the control, the participants were overweight, and the study
duration was <6 months. ADF is effective in reducing waist circumference in
adults aged ≥40 years with obesity. However, there was no difference between ADF
and continuous energy restriction, time-restricted feeding, or control with
regard to lean body mass"
-
Lipoic
acid supplements help some obese but otherwise healthy people lose weight -
Science Daily, 8/12/20 - "analyzed the effects of 24
weeks of daily, 600-milligram doses of lipoic acid supplements on 31 people,
with a similarly sized control group receiving a placebo ... The data clearly
showed a loss in body weight and body fat in people taking lipoic acid
supplements ... When taken as a dietary supplement, lipoic acid displays
additional properties that might be unrelated to the function in the
mitochondria. They include the stimulation of glucose metabolism, antioxidant
defenses and anti-inflammatory responses -- making it a possible complementary
treatment for people with diabetes, heart disease and age-related cognitive
decline ... people who lost weight on lipoic acid also reduced their blood
triglyceride levels -- that effect was clear" - See
alpha lipoic acid at Amazon.com and
iHerb.
-
Intermittent Fasting May Aid Weight Loss - NYT, 7/27/20 -
"In an eight-week trial, published in Cell Metabolism,
scientists randomly assigned 58 obese men and women to three groups. The first
ate whatever they wanted without counting calories, but only between 3 p.m. and
7 p.m. The second ate what they wanted between 1 p.m. and 7 p.m. The third, a
control group, ate without restrictions ... In both of the groups that practiced
time-restricted fasting, participants consumed an average of 550 fewer calories
a day and lost about 3 percent of their body weight. Compared with the controls,
both groups had significantly reduced fat mass, reductions in oxidative stress,
and reductions in both fasting insulin and insulin resistance, which suggest a
reduced risk for diabetes. Blood pressure, heart rate, cholesterol and
triglyceride levels were unaffected."
-
How
long should you fast for weight loss? - Science Daily, 7/15/20 -
"Participants in the 4-hour time-restricted feeding diet group were asked to eat
only between the hours of 1 p.m. and 5 p.m. Participants in the 6-hour
time-restricted feeding diet group were asked to eat only between the hours of 1
p.m. and 7 p.m. ... participants in both daily fasting groups reduced calorie
intake by about 550 calories each day simply by adhering to the schedule and
lost about 3% of their body weight. The researchers also found that insulin
resistance and oxidative stress levels were reduced among participants in the
study groups when compared with the control group. There was no effect on blood
pressure, LDL cholesterol, HDL cholesterol or triglycerides."
-
The effect of green tea
supplementation on obesity: A systematic review and dose-response meta-analysis
of randomized controlled trials - Phytother Res. 2020 May 5 -
"Combined results using the random-effects model
indicated that body weight (WMD: -1.78 kg, 95% CI: -2.80, -0.75, p = .001) and
body mass index (BMI) (WMD: -0.65 kg/m2 , 95% CI: -1.04, -0.25, p = .001) did
change significantly following GT administration. The reduction in waist
circumference (WC) after GT consumption was significant in subjects in trials
employing GT ≥800 mg/day (WMD: -2.06 cm) and with a treatment duration <12 weeks
(WMD: -2.39 cm). Following the dose-response evaluation, GT intake did alter
body weight, with a more important reduction when the GT dosage was <500 mg/day
and the treatment duration was of 12 weeks. The results of present meta-analysis
study support the use of GT for the improvement of obesity indices. Thus, we
suggest that the use of GT can be combined with a balanced and healthy diet and
regular physical exercise in the management of obese patients" - See
green tea extract at Amazon.com and
green tea extract at iHerb.
-
A randomised
controlled study shows supplementation of overweight and obese adults with
lactobacilli and bifidobacteria reduces bodyweight and improves well-being -
Sci Rep. 2020 Mar 6 - "220 Bulgarian participants (30 to
65 years old) with BMI 25–34.9 kg/m2 received Lab4P
probiotic (50 billion/day) or a matched placebo for 6 months. Participants
maintained their normal diet and lifestyle ... Significant between group
decreases in body weight (1.3 kg,
p < 0.0001), BMI (0.045 kg/m2, p < 0.0001), WC (0.94 cm, p < 0.0001) and WtHR
(0.006, p < 0.0001) were in favour of the probiotic. Stratification identified
greater body weight reductions in overweight subjects (1.88%, p < 0.0001) and in
females (1.62%, p = 0.0005). Greatest weight losses were among probiotic
hypercholesterolaemic participants (-2.5%, p < 0.0001) alongside a significant
between group reduction in small dense LDL-cholesterol (0.2 mmol/L, p = 0.0241).
Improvements in QoL and the incidence rate ratio of URTI (0.60, p < 0.0001) were
recorded for the probiotic group. No adverse events were recorded. Six months
supplementation with Lab4P probiotic resulted in significant weight reduction
and improved small dense low-density lipoprotein-cholesterol (sdLDL-C) profiles,
QoL and URTI incidence outcomes in overweight/obese individuals" - [Nutra
USA] - See probiotic supplements at
Amazon.com
and
probiotic supplements at iHerb.
-
Effects of alpha lipoic
acid as a supplement in obese children and adolescents - Cytokine. 2020 Apr
4 - "Obesity is significantly associated with
inflammatory process and oxidative stress. Alpha lipoic acid (ALA) is a potent
antioxidant that has been reported for reducing weight in animals and obese
adults in several studies but no data are available in pediatrics ... Eighty
obese children and adolescents were randomized into two groups; the treatment
group (n = 40) who received 300 mg of ALA twice daily for 3 months and the
control group (n = 40) who received placebo for 3 months ... ALA treatment group
had a significant reduction of the weight, BMI, MDA, TNF-α, and leptin levels
but a significant increase of adiponectin level (P < 0.05) compared to the
control group. However, it had no effect on FBG or lipid profile" - See
alpha lipoic acid at Amazon.com.
-
Does vitamin D status
predict weight gain or increase in waist circumference? Results from the
longitudinal Health 2000/2011 Survey - Public Health Nutr. 2020 Mar 24 -
"In men, low vitamin D status at baseline predicted ≥10
% increase in waist circumference during the follow-up when adjusted for age
only (OR for sufficient v. deficient S-25(OH)D 0·41; 95 % CI 0·25, 0·67; P for
trend <0·01), but the association with weight gain was only borderline
significant. After adjustment for potential confounders, low vitamin D status
remained a significant predictor of increase in waist circumference, but the
association with weight gain was further attenuated. In women, vitamin D status
at baseline did not predict weight gain or increase in waist circumference."
- See vitamin D at Amazon.com.
-
The Benefits of Intermittent Fasting - NYT, 2/17/20 -
"Most people trying to lose weight should strive for 16
calorie-free hours, he said, adding that “the easiest way to do this is to stop
eating by 8 p.m., skip breakfast the next morning and then eat again at noon the
next day.” (Caffeine-dependent people can have sugar- free black coffee or tea
before lunch.) But don’t expect to see results immediately; it can take up to
four weeks to notice an effect, he said ... Other animal studies have shown a
“robust disease-modifying” benefit of intermittent fasting on “a wide range of
chronic disorders, including obesity, diabetes, cardiovascular disease, cancers
and neurodegenerative brain diseases,” the researchers reported ... For example,
human studies of intermittent fasting found that it improved such disease
indicators as insulin resistance, blood fat abnormalities, high blood pressure
and inflammation, even independently of weight loss ... during a fast, the body
produces few new proteins, prompting cells to take protein from nonessential
sources, break them down and use the amino acids to make new proteins that are
essential for survival. Then, after eating, a lot of new proteins are produced
in the brain and elsewhere."
-
Could Your Morning Coffee Be a Weight-Loss Tool? - WebMD, 1/13/20 -
"Those who drank 4 cups of caffeinated coffee per day
over six months saw a nearly 4% drop in overall body fat"
-
Clinical study finds eating within 10-hour window may help stave off diabetes,
heart disease - Science Daily, 12/5/19 - "a 10-hour
time-restricted eating intervention, when combined with traditional medications,
resulted in weight loss, reduced abdominal fat, lower blood pressure and
cholesterol, and more stable blood sugar and insulin levels for participants ...
Unlike counting calories, time-restricted eating is a simple dietary
intervention to incorporate, and we found that participants were able to keep
the eating schedule ... Time-restricted eating (eating all calories within a
consistent 10-hour window) supports an individual's circadian rhythms and can
maximize health benefits ... Eating and drinking everything (except water)
within a consistent 10-hour window allows your body to rest and restore for 14
hours at night ... To reduce food intake to the 10-hour window, most
participants delayed their first meal and advanced their last meal each day, so
meals were not skipped. Although calories were not recommended to be reduced for
the intervention, some participants did report eating less, likely due to the
shorter eating window ... Overall, participants experienced improved sleep as
well as a 3-4 percent reduction in body weight, body mass index, abdominal fat
and waist circumference. Major risk factors for heart disease were diminished as
participants showed reduced blood pressure and total cholesterol. Blood sugar
levels and insulin levels also showed a trend toward improvement"
-
Effects of Spirulina supplementation on obesity: A systematic review and
meta-analysis of randomized clinical trials - Complementary Therapies in
Medicine, Dec 2019 - "Results of 5 studies (7 treatment
arms) showed a significant reduction in weight (MD: -1.56 Kg, 95% CI: -1.98 to
-1.14) after Spirulina supplementation. Subgroup analysis based on health status
revealed that weight change in obese subjects (MD: -2.06 Kg, 95% CI: -2.45 to
-1.68) was greater than overweight participants (MD: -1.28 Kg, 95% CI: -1.62 to
-0.93) following Spirulina supplementation. Also, pooled analysis showed that
Spirulina supplementation led to a significant reduction in body fat percent
(MD: -1.02, 95% CI: -1.49 to -0.54) and waist circumference (MD: -1.40, 95% CI:
-1.40 to -1.39), but not in body mass index and waist to hip ratio" - [Nutra
USA] - See spirulina at Amazon.com.
-
Gut
bacteria is key factor in childhood obesity - Science Daily, 10/30/19 -
"The medical community used to think that obesity was a
result of consuming too many calories. However, a series of studies over the
past decade has confirmed that the microbes living in our gut are not only
associated with obesity but also are one of the causes" - See
probiotic supplements at Amazon.com.
-
Molecule links weight gain to gut bacteria - Science Daily, 9/27/19 -
"Their findings could have far-ranging implications for
obesity in affluent countries and malnutrition in impoverished countries ... In
the study, published this week by Science, Dr. Lora Hooper and her research team
found that the commensal, or good, bacteria that live in the guts of mammals
program the metabolic rhythms that govern the body's absorption of dietary fat
... Most mice on that diet become obese. To our surprise, those that had no
HDAC3 in their intestinal lining were able to eat a high fat, high sugar diet
and stay lean ... disrupting the interactions between the microbiota and the
body's clock could make us more likely to become obese. These disruptions happen
frequently in modern life when we take antibiotics, work overnight shifts, or
travel internationally. But we think that our findings might eventually lead to
new treatments for obesity -- and possibly malnutrition -- by altering the
bacteria in our guts" - See
probiotic products at Amazon.com.
-
Seeking an Obesity Cure, Researchers Turn to the Gut Microbiome -= NYT,
9/10/19 - "A clinical trial published in the
journal Nature Medicine in July, for example, found that giving obese people
supplements containing a gut microbe linked to leanness in mice and humans
lowered their cholesterol, inflammation and insulin and even led to a few pounds
of weight loss compared to a control group ... Still, Dr. Yu said a capsule
containing a cocktail of beneficial microbes is never going to be a silver
bullet." - See
probiotic products at Amazon.com.
-
These
gut bacteria prevent mice from becoming obese -- what could that mean for us?
- Science Daily, 7/25/19 - "healthy mice have plenty of Clostridia -- a class of
20 to 30 bacteria -- but those with an impaired immune system lose these
microbes from their gut as they age. Even when fed a healthy diet, the mice
inevitably become obese. Giving this class of microbes back to these animals
allowed them to stay slim ... Mice experimentally treated so that Clostridia
were the only bacteria living in their gut were leaner with less fat than mice
that had no microbiome at all. They also had lower levels of a gene, CD36, that
regulates the body's uptake of fatty acids ... These insights could lead to a
therapeutic approach, Round says, with advantages over the fecal transplants and
probiotics that are now being widely investigated as ways to restore a healthy microbiota ... Round points out that research by others have shown that people
who are obese similarly lack Clostridia, mirroring the situation in these mice"
- See
probiotic products at Amazon.com.
-
Gut Bacteria Help May Boost Obese People's Health - WebMD. 7/1/19 -
""But
that was just a simple correlation," Cani said. So several years ago, his team
started to look deeper. First, they found that in lab mice, Akkermansia -- given
as live bacteria -- helped prevent weight gain from a high-fat diet ... The
important conclusion is, this type of supplement is safe and feasible ... After
three months, people on the pasteurized supplement had lost 5 pounds, on
average. Their insulin sensitivity improved by 30% in relation to the placebo
group, whose sensitivity worsened. And their total cholesterol dipped by about
9% versus the placebo group, the findings showed" - Note: I Goggled it.
I don't think it's available yet. Here's what Amazon comes up with for
probiotics for weight loss.
-
Could
coffee be the secret to fighting obesity? - Science Daily, 6/24/19 -
"The results were positive and we now need to ascertain
that caffeine as one of the ingredients in the coffee is acting as the stimulus
or if there's another component helping with the activation of brown fat. We are
currently looking at caffeine supplements to test whether the effect is similar
... Once we have confirmed which component is responsible for this, it could
potentially be used as part of a weight management regime or as part of glucose
regulation programme to help prevent diabetes."
-
Fiber Intake Predicts
Weight Loss and Dietary Adherence in Adults Consuming Calorie-Restricted Diets:
The POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study
- J Nutr. 2019 Jun 7 - "Dietary fiber intake,
independently of macronutrient and caloric intake, promotes weight loss and
dietary adherence in adults with overweight or obesity consuming a
calorie-restricted diet"
-
Sleeping with artificial light at night associated with weight gain in women
- Science Daily, 6/10/19 - "The results varied with the
level of artificial light at night exposure. For example, using a small
nightlight was not associated with weight gain, whereas women who slept with a
light or television on were 17% more likely to have gained 5 kilograms,
approximately 11 pounds, or more over the follow-up period. The association with
having light coming from outside the room was more modest ... Also, the
scientists wondered if not getting enough rest factored into the findings"
-
Mediterranean diet deters overeating, study finds - Science Daily, 4/23/19 -
"nonhuman primates on a Mediterranean diet chose not to
eat all the food available to them and maintained a normal weight ... By
comparison, the animals on a Western diet ate far more than they needed and
gained weight ... The Wake Forest School of Medicine study was a 38-month
(equivalent to about 9 years for humans) prevention trial. The diets were
formulated to closely reflect human diets with protein and fat derived largely
from animal sources in the Western diet and primarily from plant sources in the
Mediterranean diet. However, the two diets contained comparable proportions of
fat, protein and carbohydrates ... the group on the Mediterranean diet actually
ate fewer calories, had lower body weight and had less body fat than those on
the Western diet ... The Mediterranean diet also protected against non-alcoholic
fatty liver disease, known as NAFLD"
-
The FDA Just
Approved a New Prescription Weight-Loss Drug. Here's How It Works - Time,
1/15/19 - "Previously approved weight-loss drugs
typically work by targeting the brain to suppress appetite or simulate feelings
of fullness. Plenity, by contrast, helps fill the stomach when taken before a
meal. Each pill contains a mix of cellulose and citric acid, which, when
hydrated in the stomach, expands to form a hydrogel with the consistency of
chewed food. The capsules can fill about a quarter of the stomach without
contributing any calories, helping people feel full from eating less, according
to the company. The gel then passes through the digestive system just like
regular food ... “It creates a sense of satiety, but it’s not a compound that
enters the bloodstream and goes to the brain,” Apovian says. “In that respect,
it’s so unique because it’s actually benign and safe, in terms of side effects
that can cause issues centrally. It’s a very safe, low-risk alternative.”
-
Green
tea cuts obesity, health risks in mice - Science Daily, 3/14/19 -
"Green tea cut obesity and a number of inflammatory
biomarkers linked with poor health ... Mice fed a diet of 2 percent green tea
extract fared far better than those that ate a diet without it ... The benefits
seen in the new study, published in the Journal of Nutritional Biochemistry,
appear to stem from improved gut health, including more beneficial microbes in
the intestines of the mice and less permeability in the intestinal wall -- a
condition typically called "leaky gut" in people ... The mice fed a high-fat
diet supplemented with green tea gained about 20 percent less weight and had
lower insulin resistance than mice fed an otherwise identical diet without tea
... Those mice also had less inflammation within fat tissue and the intestine.
Furthermore, the green tea appeared to protect against the movement of endotoxin,
the toxic bacterial component, out of their guts and into the bloodstream ...
Green tea consumption in the experiment would be equivalent to about 10 cups of
green tea throughout the day for a person" - See
green tea extract at Amazon.com.
-
More
protein and fewer calories help older people lose weight safely - Science
Daily, 2/14/19 - "two groups: a six-month low-calorie meal plan that included
more than 1 gram of protein per kilogram of body weight, plus adequate calcium
and vitamin D; or a weight stability group targeting .8 grams of protein per
kilogram of body weight, which is the current, government-recommended dietary
allowance ... Participants lost about 18 pounds, most of it fat (87 percent),
and preserved muscle mass. The control group lost about half a pound ... Even
when participants lost weight, they maintained bone mass. In fact, trabecular
bone score, a measure of bone quality that predicts fracture risk, seemed to
improve ... Fat was lost in the stomach, hips, thighs and rear, which is
important for preventing or controlling cardiometabolic diseases such as
diabetes and stroke ... Participants' score on the Healthy Aging Index, which
measures biomarkers that predict mortality and longevity, improved by 0.75
points" - See protein powder
at Amazon.com.
-
Body Composition Changes
in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a
Brief Review (.pdf) - Nutrients. 2018 Dec 3;10(12) - "There are a few
dietary supplements that appear to help preserve LBM during weight loss or to
reduce the loss of LBM as compared to diet alone. One such dietary supplement
that appears to have this “LBM sparing” effect is chromium picolinate. For the
reasons shared in this paper, it seems logical to include CrP as part of any
reduced calorie (diet) plan as a means of keeping metabolically active LBM.
Weight loss without CrP may be at the cost of LBM, thus, this adjunctive
strategy appears worthy of further research and applied practice. A
comprehensive approach, integrating evidence-guided macronutrient and calorie
intake, resistance exercise, and chromium picolinate may be the most effective
approach to preserving or increasing lean body mass while maximizing body fat
mass reductions." - [Nutra USA] - See chromium
picolinate at Amazon.com.
-
Cordycepin reduces weight
through regulating gut microbiota in high-fat diet-induced obese rats -
Lipids Health Dis. 2018 Dec 6 - "Our study suggests that cordycepin can reduce
body weight and microbiome done by cordycepin seems be a result among its
mechanisms of obesity reduction" - See
cordyceps at Amazon.com.
-
Resveratrol
supplementation significantly influences obesity measures: a systematic review
and dose-response meta-analysis of randomized controlled trials - Obes Rev.
2018 Dec 5 - "This study aimed to summarize earlier
randomized controlled trials on the effects of resveratrol supplementation on
body weight (BW), body mass index (BMI), waist circumference (WC) and fat mass
(FM) ... Taken together, the data suggest that resveratrol supplementation has
beneficial effects to reduce BW, BMI and WC, but not FM" - See
resveratrol products at Amazon.com.
-
A New Study Says
Low-Carb Diets May Help You Lose Weight. But Are Carbs Really So Bad For You?
- Time, 11/16/18 - "people on low-carb diets burned more
than 200 extra calories per day compared to people on high-carb diets, avoiding
the reduction in calorie burning that can follow significant weight loss. Over
time, the researchers write, that enhanced calorie burn could not only maintain
existing weight loss but also help low-carb dieters slim down more than people
on other eating plans. They estimated that a person on a low-carb plan could
lose about 10% of his body weight over three years simply by reducing his carb
consumption — even if his total calorie intake didn’t change ... The body breaks
down carbohydrates into glucose, triggering the release of insulin and
potentially increasing a person’s risk of developing both Type-2 diabetes and
obesity — so some researchers believe that cutting back on carbs can result in
trimmer waistlines. Some studies have suggested that long-vilified fat,
meanwhile, may regulate blood sugar and keep you full throughout the day,
helping keep weight in check" - Note: The article is poorly
written. On the one hand they argue that the low-carbers burned an extra
200 calories. Then on the other hand they argue that it was water loss.
Calories and water loss are two different things. It doesn't make sense.
-
How a Low-Carb Diet Might Help You Maintain a Healthy Weight - NYT, 11/14/18
- "overweight adults who cut carbohydrates from their
diets and replaced them with fat sharply increased their metabolisms. After five
months on the diet, their bodies burned roughly 250 calories more per day than
people who ate a high-carb, low-fat diet, suggesting that restricting carb
intake could help people maintain their weight loss more easily ... The new
study is unique in part because of its size and rigor. It is among the largest
and most expensive feeding trials ever conducted on the subject ... experts like
Dr. Ludwig, argue that the obesity epidemic is driven by refined carbohydrates
such as sugar, juices, bagels, white bread, pasta and heavily processed cereals.
These foods tend to spike blood sugar and insulin, a hormone that promotes fat
storage, and they can increase appetite"
-
Daily
fasting works for weight loss, finds report on 16:8 diet - Science Daily,
6/18/18 - "Between the hours of 10 a.m. and 6 p.m. the
dieters could eat any type and quantity of food they desired, but for the
remaining 16 hours they could only drink water or calorie-free beverages. The
study followed the participants for 12 weeks ... those who followed the
time-restricted eating diet consumed fewer calories, lost weight and had
improvements in blood pressure. On average, participants consumed about 350
fewer calories, lost about 3 percent of their body weight and saw their systolic
blood pressure decreased by about 7 millimeters of mercury (mm Hg), the standard
measure of blood pressure. All other measures, including fat mass, insulin
resistance and cholesterol, were similar to the control group" - Note:
It sounds good on paper but some people can't sleep when their stomach is on
empty.
-
Effects of Panax ginseng
on Obesity in Animal Models: A Systematic Review and Meta-Analysis - Evid
Based Complement Alternat Med. 2018 May 15;2018:2719794 -
"Our meta-analysis indicated that oral administration of
P. ginseng significantly inhibits weight gain and improves serum lipid profiles
in animal obesity models" - See
ginseng at Amazon.com.
-
Eating frequency is
inversely associated with BMI, waist circumference and the proportion of body
fat in Korean adults when diet quality is high, but not when it is low: analysis
of the Fourth Korea National Health and Nutrition Examination Survey (KNHANES
IV) - Br J Nutr. 2018 Apr;119(8):918-927 - "EF was
inversely associated with each obesity indicator, including body fat percentage
(BF%), BMI and waist circumference (WC), showing a significant linear trend
(P<0·001 for BF%, WC and BMI)"
-
Pasta Promotes Weight Loss
as Part of a Low-Glycemic Index Diet - Medscape, 4/6/18 -
"Pasta is an
important example of a food that is considered a refined carbohydrate but has a
low GI ... Pooled analyses again support a beneficial effect of pasta within the
context of a low-GI diet on body mass index, where body mass index dropped by
0.26 kg/m2 (95% confidence interval, −0.36 to −0.16 kg/m2; P < .001) compared
with higher-GI control diets"
-
High-energy breakfast promotes weight loss - Science Daily, 3/18/18 -
"The patients were randomly assigned to consume one of
two different weight-loss diets, which contained an equal number of daily
calories, for three months. One group (Bdiet) ate three meals: a large
breakfast, a medium-sized lunch and a small dinner. The second group (6Mdiet)
ate the traditional diet for diabetes and weight loss: six small meals evenly
spaced throughout the day, including three snacks ... At three months, while the
Bdiet group lost 5 kilograms (11 pounds) the 6Mdiet group gained 1.4 kg (3 lb)
... Fasting glucose levels decreased 54 mg/dl (from 161 to 107) in the Bdiet
group but only 23 mg/dl (from 164 to 141) in the 6Mdiet group. Overall mean
glucose levels dropped in the first 14 days by 29 mg/dl (from 167 to 138 mg/dl)
and 38 mg/dl (from 167 to 129 mg/dl) after three months in the Bdiet group.
Overall mean glucose levels dropped only 9 mg/dl (from 171 to 162 mg/dl) in the
first 14 days and only 17 mg/dl (from 171 to 154 mg/dl) in the 6Mdiet group"
-
Counting Calories Is Not the Key to Weight Loss, New Study Finds - NYT,
2/20/18 - "a new study, published Tuesday in JAMA, may
turn that advice on its head. It found that people who cut back on added sugar,
refined grains and highly processed foods while concentrating on eating plenty
of vegetables and whole foods — without worrying about counting calories or
limiting portion sizes — lost significant amounts of weight over the course of a
year ... The strategy worked for people whether they followed diets that were
mostly low in fat or mostly low in carbohydrates. And their success did not
appear to be influenced by their genetics or their insulin-response to
carbohydrates, a finding that casts doubt on the increasingly popular idea that
different diets should be recommended to people based on their DNA makeup or on
their tolerance for carbs or fat"
-
Effect of Curcumin on
Anthropometric Measures: A Systematic Review on Randomized Clinical Trials -
J Am Coll Nutr. 2018 Jan 9:1-8 - "It seems that the bioavailable form of
curcumin can reduce obesity and overweight" - See
curcumin products at Amazon.com.
-
Comparison of
Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric
Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With
Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial - J
Am Coll Nutr. 2018 Jan 9:1-11 - "Significant reductions in weight (by 1.1%) and
BMI were found in the resveratrol group compared to the placebo group"
- See Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules
at Amazon.com.
-
Black
tea may help with weight loss, too - Science Daily, 10/4/17 -
"The study found that both black and green tea changed
the ratio of intestinal bacteria in the animals: The percentage of bacteria
associated with obesity decreased, while bacteria associated with lean body mass
increased ... It was known that green tea polyphenols are more effective and
offer more health benefits than black tea polyphenols since green tea chemicals
are absorbed into the blood and tissue ... Our new findings suggest that black
tea, through a specific mechanism through the gut microbiome, may also
contribute to good health and weight loss in humans ... The results suggest that
both green and black teas are prebiotics, substances that induce the growth of
good microorganisms that contribute to a person's well-being"
-
Effect of high-protein
meal replacement on weight and cardiometabolic profile in overweight/obese Asian
Indians in North India - Br J Nutr. 2017 Jun 2 -
"high-protein meal replacement (HPMR) ... These findings show that intervention
with HPMR may lead to significant weight loss and improvement in obesity
measures, metabolic, lipid and inflammatory parameters and hepatic transaminases
in overweight/obese Asian Indians"
-
Sulforaphane, a phytochemical in broccoli sprouts, ameliorates obesity -
Science Daily, 3/7/17 - "the mice fed with sulforaphane
exhibited the weight gain rate 15% lower than that of the mice fed without
sulforaphane, 20% visceral fat reduction, and reduction of augmentation of their
hepatic steatosis and blood glucose level" - See
Jarrow Formulas BroccoMax at Amazon.com.
-
Eating in social settings may be greatest temptation for dieters - American
Heart Association, 3/7/17 - "the chance of diet lapse
was about 60 percent when eating with others ... participants lapse in diet
almost half the time when alone"
-
Whole-Grain Foods May Help You Stay Slim - WebMD, 2/8/17 -
"Those on the whole-grain diet absorbed fewer calories
and had greater fecal output. Their resting metabolic rate (calories burned at
rest) was also higher ... The energy deficit in those eating whole grains
compared to refined grains would be equivalent to the calories you would burn if
you were to walk about a mile [in] about 20 or 30 minutes ... ''We don't know
over the long term if it would translate to weight loss," Karl said, but his
team suspects it would. "This would translate to about 5 pounds in a year," ...
In a related study in the same issue of the journal, the same group of
researchers found that people who ate whole grains had modest improvements in
healthy gut environment and certain immune responses. Whole-grain intake has
also been linked with a reduced risk of heart disease, type 2 diabetes and some
cancers"
-
Salba-chia (Salvia
hispanica L.) in the treatment of overweight and obese patients with type 2
diabetes: A double-blind randomized controlled trial - Nutr Metab Cardiovasc
Dis. 2016 Dec 9 - "Preliminary findings indicate that consumption of Salba-chia
(Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes
and suppresses appetite ... A double-blind, randomized, controlled trial with
two parallel groups involved 77 overweight or obese patients with type 2
diabetes (HbA1c: 6.5-8.0%; BMI: 25-40 kg/m2). Both groups followed a 6-month
calorie-restricted diet; one group received 30 g/1000 kcal/day of Salba-chia,
the other 36 g/1000 kcal/day of an oat bran-based control ... At 6-months,
participants on Salba-chia had lost more weight than those on control (1.9 ± 0.5
kg and 0.3 ± 0.4 kg, respectively; P = 0.020), accompanied by a greater
reduction in waist circumference (3.5 ± 0.7 cm and 1.1 ± 0.7 cm, respectively; P
= 0.027). C-reactive protein was reduced by 1.1 ± 0.5 mg/L (39 ± 17%) on
Salba-chia, compared to 0.2 ± 0.4 mg/L (7 ± 20%) on control (P = 0.045). Plasma
adiponectin on the test intervention increased by 6.5 ± 0.7%, with no change
observed on control" - Note: 1.9 - 0.3 = 1.6 kilograms more weight loss or 3.5
pounds. See Salba-chia seeds at Amazon.com.
-
The Root Extract of
Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing
the Energy Metabolism in Skeletal Muscle - Nutrients. 2017 Jan 4;9(1) -
"Radix Pueraria lobata (RP) has been reported to prevent
obesity and improve glucose metabolism ... The present study demonstrates that
RP can prevent diet-induced obesity, glucose tolerance, and skeletal muscle
atrophy in mouse models of obesity. The mechanism responsible for the effect of
RP appears to be related to the upregulation of energy metabolism in skeletal
muscle, which at the molecular level may be associated with PGC-1α and AMPK
activation" - See Pueraria lobata at
Amazon.com.
-
Omega-3
fatty acids stimulate brown adipose tissue metabolism - Science Daily,
11/21/16 - "The main function of brown adipose tissue is
to burn calories and to make physical warmth out of fat (thermogenesis).
However, a recent study by this research team has defined that brown adipose
tissue also acts as an endocrine organ and can secrete factors that activate fat
and carbohydrates metabolism ... these molecules, released by the adipose tissue
(brown adipocytes or batokines) have positive metabolic effects. For this
reason, they could be used in new therapies for obesity and related metabolic
diseases" - See
fish oil supplements at Amazon.com.
-
Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum
Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial -
j.ebiom.2016.10.036 - "We investigated the possible effects of Bifidobacterium
animalis ssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra
polydextrose (LU) on body fat mass and other obesity-related parameters ... For
relative change in body fat mass, LU + B420 showed a − 4.5% (−1.4 kg, P = 0.02,
N = 37) difference to the Placebo group, whereas LU (+0.3%, P = 1.00, N = 35)
and B420 (−3.0%, P = 0.28, N = 24) alone had no effect (overall ANOVA P = 0.095,
Placebo N = 35). A post-hoc factorial analysis was significant for B420 (−4.0%,
P = 0.002 vs. Placebo). Changes in fat mass were most pronounced in the
abdominal region, and were reflected by similar changes in waist circumference.
B420 and LU + B420 also significantly reduced energy intake compared to Placebo"
- [Nutra
USA] - See
probiotic products at Amazon.com
and polydextrose at Amazon.com.
-
Anti-obese effects of two
Lactobacilli and two Bifidobacteria on ICR mice fed on a high fat diet -
Biochem Biophys Res Commun. 2016 Nov 11;480(2):222-227 -
"high fat diet (HFD) ... The beneficial effects of the probiotic bacteria are
suggested to be strain dependent. In this study, two candidate lactobacteria
strains, Lactobacillus casei IBS041, Lactobacillus acidophilus AD031 and two
bifidobacteria strains, Bifidobacterium bifidum BGN4 and Bifidobacterium longum
BORI, were individually administered to HFD-fed mice for 8 weeks. B. longum BORI
significantly suppressed mouse weight gain without affecting food intake. L.
acidophilus and B. bifidum BGN4 significantly decreased triglyceride levels in
mouse liver while B. longum BORI significantly lowered total cholesterol levels
in liver. L. acidophilus and B. bifidum BGN4 significantly inhibited serum
activities of aspartate transaminase and alanine transaminase. Diet
supplementation with L. acidophilus, B. bifidum BGN4 and B. longum BORI
efficiently improved hepatocyte hydropic degeneration and hepatic steatosis. Of
the four probiotic candidates, the bifidobacteria B. longum BORI and B. bifidum
BGN4, developed in our laboratory, and L. acidophilus AD031showed excellent
anti-obesity effects and suppressed lipid deposition in liver" - See
probiotic products at Amazon.com.
-
Mulberry extract activates brown fat, shows promise as obesity treatment -
Science Daily, 10/26/16 - "a natural compound in
mulberries, called "rutin," can activate the BAT in our bodies to increase
metabolism and facilitate weight loss ... Rutin treatment significantly reduced
adiposity, increased energy expenditure, and improved glucose homeostasis in
both the genetically obese mice and the mice with diet-induced obesity.
Specifically, the researchers found that rutin directly binds to and stabilizes
SIRT1 (NAD-dependent deacetylase sirtuin-1), leading to hypoacetylation of PGC1α
protein, which stimulates Tfam transactivation and eventually augments
mitochondrial number and UCP1 activity in BAT" - See
rutin at Amazon.com.
-
Body fat link to bacteria in
faeces - BBC, 9/26/16 - "The researchers found the
strongest links with visceral fat, where participants with a high diversity of
bacteria in their faeces had lower levels of visceral fat ... This type of body
fat is bad news because it is stored in the stomach area around important organs
such as the liver, pancreas and intestines and is linked with higher risks of
cardiovascular disease and diabetes ... One theory is that a lack of variety in
faecal bacteria could lead to the domination of high levels of gut microbes
which are good at turning carbohydrates into fat" - See
probiotic products at Amazon.com.
-
n-3 Fatty acids preserve
muscle mass and insulin sensitivity in a rat model of energy restriction -
Br J Nutr. 2016 Sep 13:1-12 - "dietary n-3 PUFA prevent
the loss of muscle mass associated with energy restriction, probably by an
improvement in the insulin-signalling pathway activation, in relation to
enrichment of plasma membranes in n-3 LC-PUFA" - See
fish oil supplements at Amazon.com.
-
Standing desks lower BMI, research shows - Science Daily, 8/23/16 -
"the students who had the stand-biased desks for both
years averaged a three percent drop in BMI while those in traditional desks
showed the two percent increase typically associated with getting older"
-
Average American 15 Pounds Heavier in Two Decades - WebMD, 8/3/16 -
"since
the late 1980s and early 1990s, the average American has put on 15 or more
additional pounds without getting any taller"
-
Metformin-sustained Weight
Loss and Reduced Android Fat Tissue at 12 Months in EMPOWIR (Enhance the
Metabolic Profile of Women With Insulin Resistance) - WebMD, 8/2/16 -
"carbohydrate-modified diet (CMD) and were then
randomized to one of three arms for 6 months (phase 1): CMD alone (D), or in
combination with metformin (M), or metformin + rosiglitazone (MR), with
rerandomization of the D group to one of the active treatment arms ... Mean
(±SD) BW decreased significantly at 12 months in the M arm: 85.1 ± 8.5 kg to
79.8 ± 9.0 kg (P = .0003), with 54% of variance in weight over time explained by
M treatment. Mean (±SD) percent android fat decreased significantly in the M and
D arms: 53.5 ± 4.8% to 49.3 ± 7.6% (P = .010) and 52.9 ± 6.2% to 48.1 ± 8.7% (P
= .021)" - See
metformin at The Antiaging Store.
-
Body Weight Management in
Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A
Double-Blind, Randomized, Placebo-Controlled Trial - J Evid Based
Complementary Altern Med. 2016 Apr 6 - "A total of 52
subjects under chronic stress received either Ashwagandha (300 mg) or placebo
twice daily. Primary efficacy measures were Perceived Stress Scale and Food
Cravings Questionnaire. Secondary efficacy measures were Oxford Happiness
Questionnaire, Three-Factor Eating Questionnaire, serum cortisol, body weight,
and body mass index. Each subject was assessed at the start and at 4 and 8
weeks. The treatment with Ashwagandha resulted in significant improvements in
primary and secondary measures. Also, the extract was found to be safe and
tolerable. The outcome of this study suggests that Ashwagandha root extract can
be used for body weight management in adults under chronic stress" -
[Nutra
USA] - See
Ashwagandha at Amazon.com.
-
Subchronic treatment with
grape-seed phenolics inhibits ghrelin production despite a short-term
stimulation of ghrelin secretion produced by bitter-sensing flavanols - Mol
Nutr Food Res. 2016 Jul 15 - "Grape-seed phenolic compounds have recently been
described as satiating agents in rats when administered as a whole phenolic
extract (GSPE) ... The sustained satiating effects of GSPE are related to a
long-term decrease in ghrelin expression" - See
Best Naturals Grape Seed Extract 400 mg Veggie
Capsule, 120 Count.
-
Ghrelin - wikipedia.org - "When the stomach is empty, ghrelin is
secreted. When the stomach is stretched, secretion stops.a It acts
on hypothalamic brain cells both to increase hunger, and to increase
gastric acid secretion and gastrointestinal motility to prepare the
body for food intake"
-
Consuming probiotics promotes weight loss, reduces BMI - Science Daily,
7/11/16 - "Researchers from the Department of
Cardiology, Taizhou People's Hospital, Taizhou, China combined the findings of
25 randomized human trials investigating the impact of probiotic consumption on
body weight and BMI in over 1,900 healthy adults. They found taking probiotics
reduced BMI and body weight with the greatest reduction in BMI occurring in
overweight adults. Interestingly, ingesting more than one type of probiotic and
taking probiotics for 8 weeks or more resulted in increased weight loss"
- See
probiotic products at Amazon.com.
-
Dairy Intake Enhances Body
Weight and Composition Changes during Energy Restriction in 18-50-Year-Old
Adults-A Meta-Analysis of Randomized Controlled Trials - Nutrients. 2016 Jul
1;8(7) - "Participants consumed between 2 and 4 standard
servings/day of dairy food or 20-84 g/day of whey protein compared to low dairy
control diets, over a median of 16 weeks. A greater reduction in body weight
(-1.16 kg [-1.66, -0.66 kg], p < 0.001, I² = 11%, QR = high, n = 644) and body
fat mass (-1.49 kg [-2.06, -0.92 kg], p < 0.001, I² = 21%, n = 521, QR = high)
were found in studies largely including women (90% women). These effects were
absent in studies that imposed resistance training (QR = low-moderate). Dairy
intake resulted in smaller loss of lean mass (all trials pooled: 0.36 kg [0.01,
0.71 kg], p = 0.04, I² = 64%, n = 651, QR = moderate)"
-
The effect of
(L-)carnitine on weight loss in adults: a systematic review and meta-analysis of
randomized controlled trials - Obes Rev. 2016 Jun 22 -
"Results from meta-analysis of eligible trials revealed
that subjects who received carnitine lost significantly more weight (MD:
-1.33 kg; 95% CI: -2.09 to -0.57) and showed a decrease in body mass index (MD:
-0.47 kg m-2 ; 95% CI: -0.88 to -0.05) compared with the control group. The
results of meta-regression analysis of duration of consumption revealed that the
magnitude of weight loss resulted by carnitine supplementation significantly
decreased over time (p = 0.002). We conclude that receiving the carnitine
resulted in weight loss" - See
L-carnitine at Amazon.com.
-
5 Diet Drugs: Which Ones Work? - WebMD, 6/14/16 -
"People on Qsymia typically lost the most weight -- almost 20 pounds more,
versus study patients given placebo pills. They were also nine times more likely
to drop at least 5 percent of their initial weight"
-
Copper
is key in burning fat - Science Daily, 6/7/16 -
"copper has been gaining increasing attention over the past decade for its role
in certain biological functions. It has been known that copper is needed to form
red blood cells, absorb iron, develop connective tissue and support the immune
system ... We find that copper is essential for breaking down fat cells so that
they can be used for energy ... It acts as a regulator. The more copper there
is, the more the fat is broken down. We think it would be worthwhile to study
whether a deficiency in this nutrient could be linked to obesity and
obesity-related diseases ... an adult's estimated average dietary requirement
for copper is about 700 micrograms per day. The Food and Nutrition Board also
found that only 25 percent of the U.S. population gets enough copper daily ...
Too much copper can lead to imbalances with other essential minerals, including
zinc ... Of the copper in human bodies, there are particularly high
concentrations found in the brain ... copper helps brain cells communicate with
each other by acting as a brake when it is time for neural signals to stop"
- See
Jarrow Zinc Balance at Amazon.com.
-
Sulforaphane induces
adipocyte browning and promotes glucose and lipid utilization - Mol Nutr
Food Res. 2016 May 24 - "Obesity is closely related to
the imbalance of white adipose tissue storing excess calories, and brown adipose
tissue dissipating energy to produce heat in mammals. Recent studies revealed
that acquisition of brown characteristics by white adipocytes, termed
"browning," may positively contribute to cellular bioenergetics and metabolism
homeostasis ... SFN-induced browning of white adipocytes enhanced the
utilization of cellular fuel, and SFN is a promising strategy to combat obesity
and obesity-related metabolic disorder" -
See
sulforaphane at Amazon.com.
-
Beneficial effects of
Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic
syndrome: A randomized trial. Effects of probiotics on metabolic syndrome -
Nutrition. 2016 Jun;32(6):716-9 - "Daily ingestion of 80
mL fermented milk with 2.72 × 10(10) colony-forming units of B. lactis HN019
showed significant reduction in body mass index (P = 0.017), total cholesterol
(P = 0.009), and low-density lipoprotein (P = 0.008) compared with baseline and
control group values. Furthermore, a significant decrease in tumor necrosis
factor-α (P = 0.033) and interleukin-6 (P = 0.044) proinflammatory cytokines was
observed" - [Nutra
USA] - Note: Bifidobacterium lactis is one of the bacterial in the
Garden of Life Primal Defense ULTRA I take.
-
Effect of
probiotics on body weight and body-mass index: a systematic review and
meta-analysis of randomized, controlled trials - Int J Food Sci Nutr. 2016
May 5 - "Probiotic consumption significantly reduced
body weight by 0.59 kg (95% CI, 0.30-0.87) and BMI by 0.49 kg/m2 (95% CI,
0.24-0.74). A greater reduction in BMI was found with multiple species of
probiotics. Subgroup analysis of trials with intervention duration ≥8 weeks
found a more significant reduction in BMI. Limiting analysis to trials with a
baseline BMI ≥25 kg/m2 showed a greater reduction in BMI" - See
probiotic products at Amazon.com.
-
Capsaicinoids Supplementation Reduces Appetite and Body Circumferences in
Healthy Men and Women A Placebo Controlled Randomized Double Blind Study -
The FASEB Journal Mar 2016 - "randomly assigned by fat
mass to ingest either CAP (2mg CAP, CX1 or 4mg CAP, CX2 [CX, Capsimax���,
OmniActive Health Technologies Ltd.]) or placebo (corn starch, PLA) for 12 weeks
... baseline (T1), 6 weeks (T2) and 12 weeks (T3) ... Waist: hip ratio
measurements showed a main effect for time (p = 0.034) with post-hoc tests
revealing a significant (p = 0.024) decrease in CX1 from T1 to T2. Appetite
questionnaire responses indicated a significant main effect for time from T1 to
T2 (p = 0.004) and T1 to T3 (p = 0.001) suggesting supplementation of CAP
reduced appetite" - [Nutra
USA] - See Capsimax® at Amazon.com.
-
Effects of Supplementation with Curcumin on Serum Adipokine Concentrations: A
Randomized Controlled Trial - Nutrition, Mar 2016 -
"randomly assigned to curcumin (n=59; 1000 mg/day) or placebo (n=58) for 8 weeks
... Eight-week supplementation with curcumin was associated with a significant
increase in serum adiponectin levels (p<0.001), and a reduction in serum leptin
concentrations (p<0.001). Serum leptin:adiponectin ratio was also improved by
curcumin (p<0.001). These beneficial effects of curcumin remained significant
after adjustment for changes in serum lipids and glucose concentrations, and
baseline differences in BMI and serum levels of glucose and HbA1c as potential
confounders of treatment response. Meta-analysis suggested that curcumin
supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14, 147.42;
p=0.0330), and reduce leptin by 26.49%" - [Nutra
USA] - See
curcumin products at Amazon.com.
-
Reduced Fat Mass and
Increased Lean Mass in Response to 1 Year of Melatonin Treatment in
Postmenopausal Women - Medscape, 4/4/16 - "Our
results suggest a possibly beneficial effect of melatonin on body composition
and lipid metabolism as 1 year of treatment reduces fat mass, increases lean
mass and is associated with a trend towards an increase in adiponectin" -
See
melatonin at Amazon.com.
-
Ask Well: Can Vinegar Aid Weight Loss? - NYT, 3/29/16 -
"The weight loss claims hinge mostly on a 2009 clinical
trial of obese Japanese adults that found those who consumed a beverage
containing one or two tablespoons of vinegar every day lost two to four pounds
after 12 weeks, while a comparison group given a plain beverage did not lose
weight ... Several studies have shown that consuming small amounts of vinegar
before a meal containing starches may blunt a rise in blood sugar afterward,
reducing the glycemic response by 20 to 40 percent" - See
Apple cider vinegar at Amazon.com
- 1 Source Natural 500 mg tablet equals 2 tsb of vinegar. 4.5 tablets
equals about 3 tablespoons by my calculations.
-
Peanuts, peanut butter may hold key to preventing obesity - Science Daily,
3/4/16 - "Instructors guided 257 Latino adolescents from
three Houston-area charter schools through a program of physical activity and
nutrition education. About half the students received a snack of peanuts or
peanut butter three to four times a week, while the rest received the snack
fewer than once a week ... At the end of the period, those students who received
the snack more regularly experienced a decrease in their overall BMI (-.7kg/m2)
compared to those who did not receive the regular peanut snack (-.3kg/m2). The
researchers conclude that afterschool programs and schools can replace energy
dense, unhealthy snacks with peanuts to provide a healthier alternative for
children" - See Planters Trail Mix, Fruit &
Nut, 2-oz. Bags (Count of 72) which is what I have for dessert
every evening. They're also great for hiking.
-
Anti-obesity
effects of artificial planting blueberry (Vaccinium ashei) anthocyanin in
high-fat diet-treated mice - Int J Food Sci Nutr. 2016 Feb 22:1-8 -
"This study aimed to evaluate the anti-obesity effects
of artificial planting blueberry (Vaccinium ashei) anthocyanin (BA) in high-fat
diet-induced obese male C57BL/6 mice. BA at doses of 50, 100, and 200 mg/kg was
supplemented in the daily food of obese C57BL/6 mice during an 8-week
experiment. Our findings indicate that consumption of BA at high doses reduced
body weight by 19.4%, whereas both low and middle doses did not affect the body
weight. Furthermore, BA supplementation at high dose could effectively decrease
serum glucose, attenuate epididymal adipocytes, improve lipid profiles, and
significantly down-regulate expression levels of TNFα, IL-6 PPARγ, and FAS
genes" - See
blueberry extract at Amazon.com.
-
Metformin:
an Old Therapy that Deserves a New Indication for the Treatment of Obesity -
Curr Atheroscler Rep. 2016 Apr;18(4):16 - "Metformin is
not currently used for weight loss or diabetes prevention because it lacks an
FDA indication for obesity and/or pre-diabetes treatment. Based on the evidence,
metformin has been shown to decrease the incidence of type 2 diabetes, and
compares favorably to other weight-loss medications in terms of efficacy as well
as safety. Thus, metformin should be considered for a treatment indication in
patients with these conditions" - See
metformin at The Antiaging Store.
-
L-Arginine
promotes gut hormone release and reduces food intake in rodents - Diabetes
Obes Metab. 2016 Feb 11 - "L-Arg reduced food intake and
stimulated gut hormone release in rodents" - See
L-arginine products at Amazon.com.
-
Single-blind, placebo controlled randomised clinical study of chitosan for body
weight reduction - Nutr J. 2016 Jan 8;15(1):3 - "A phase IV, randomised,
multicentre, single-blind, placebo-controlled, clinical study was conducted by
administering chitosan capsules (500 mg, five/day) and indistinguishable placebo
capsules as daily supplements to 96 overweight and obese subjects for 90 days
... The mean changes in body weight were -1.78 ± 1.37 kg and -3.10 ± 1.95 kg at
day 45 and day 90 respectively in chitosan group which were significantly
different (p < 0.0001) as compared to placebo. BMI was decreased by10.91 fold
compared to placebo after 90 day administration. In concert with this, there was
also reduction in body composition and anthropometric parameters together with
improvement in QoL score. Chitosan was also able to reduce HbA1C levels (below 6
%) in subjects who had initial higher values. The mean caloric intake shows that
there was no change in dietary habits of subjects in both groups" -
[Nutra
USA] -
Note: 3.1 kilograms is 6.8 pounds. See chitosan products at Amazon.com.
-
Oral
carnitine supplementation reduces body weight and insulin resistance in women
with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled
trial - Clin Endocrinol (Oxf). 2015 Dec 15 - "60
overweight patients diagnosed with PCOS were randomized to receive either 250 mg
carnitine supplements (n=30) or placebo (n=30) for 12 weeks ... At the end of
the 12 weeks, taking carnitine supplements resulted in a significant reduction
in weight (-2.7±1.5 vs. +0.1±1.8 kg, P<0.001), BMI (-1.1±0.6 vs. +0.1±0.7 kg/m2
, P<0.001), waist circumference (WC) (-2.0±1.3 vs. -0.3±2.0 cm, P<0.001) and hip
circumference (HC) (-2.5±1.5 vs. -0.3±1.8 cm, P<0.001) compared with placebo. In
addition, compared with placebo, carnitine administration in women with PCOS led
to a significant reduction in fasting plasma glucose (-0.38±0.36 vs. +0.11±0.97
mmol/L, P=0.01), serum insulin levels (-14.39±25.80 vs. +3.01±37.25 pmol/L,
P=0.04), homeostasis model of assessment-insulin resistance (-0.61±1.03 vs.
+0.11±1.43, P=0.04) and dehydroepiandrosterone sulfate (-3.64±7.00 vs.
-0.59±3.20 μmol/L, P=0.03)" - See
L-carnitine at Amazon.com.
-
Fish oil
helps transform fat cells from storage to burning - Science Daily, 12/17/15
- "fish oil transforms fat-storage cells into
fat-burning cells, which may reduce weight gain in middle age. Fish oil
activates receptors in the digestive tract, fires the sympathetic nervous
system, and induces storage cells to metabolize fat ... The team fed a group of
mice fatty food, and other groups fatty food with fish oil additives. The mice
that ate food with fish oil, they found, gained 5-10% less weight and 15-25%
less fat compared to those that did not consume the oil" - See
fish oil supplements at Amazon.com.
-
Relation
between plasma antioxidant vitamin levels, adiposity and cardio-metabolic
profile in adolescents: Effects of a multidisciplinary obesity programme -
Clin Nutr. 2015 Nov 7 - "Plasma lipid-soluble
antioxidant vitamin and carotenoid levels are associated with reduced adiposity,
greater weight loss and an improved cardio-metabolic profile in overweight and
obese adolescents"
-
Citrus
flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol
accumulation in skeletal muscle of obese ovariectomized mice - Mol Nutr Food
Res. 2015 Nov 17 - "Dietary naringenin suppressed weight gain, lowered
hyperglycemia, and decreased intra-abdominal adiposity evaluated by magnetic
resonance imaging. Naringenin-fed mice exhibited elevated locomotor activity
monitored by infrared beam breaks, maintained muscle mass, and reduced muscle
diacylglycerol content" - See naringenin at Amazon.com.
-
Higher
Eating Frequency Does Not Decrease Appetite in Healthy Adults - J Nutr. 2015
Nov 11 - "The results from this study in 12 healthy
adults do not support the popularized notion that small, frequent meals help to
decrease overall appetite"
-
Konjac
Glucomannan Dietary Supplementation Causes Significant Fat Loss in Compliant
Overweight Adults - J Am Coll Nutr. 2015 Oct 22 - "supplement containing
either 3 g of konjac glucomannan ... 30 minutes before eating ... when subjects
were classified as either compliant or partially compliant using the compliance
measures, statistically significant reductions in scale weight, percentage body
fat, fat mass, total cholesterol, and low-density lipoprotein (LDL) cholesterol
were found in the glucomannan group compared to the placebo group" - See konjac glucomannan at Amazon.com.
-
Eating
Frequency Is Positively Associated with Overweight and Central Obesity in US
Adults - J Nutr. 2015 Oct 14 - "eating frequency
(EF) ... meal frequency (MF), and snack frequency (SF) ... This cross-sectional
study suggests that higher EF, MF, and SF are associated with increased
likelihood of overweight/obesity and central obesity in US adults"
-
Resveratrol induces
brown-like adipocyte formation in white fat through activation of AMP-activated
protein kinase (AMPK) α1 - Int J Obes (Lond). 2015 Jun;39(6):967-76 -
"Resveratrol induces brown-like adipocyte formation in
iWAT via AMPKα1 activation and suggest that its beneficial antiobesity effects
may be partly due to the browning of WAT and, as a consequence, increased oxygen
consumption" - [Nutra
USA] - See
ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count
at Amazon.com.
-
Ursolic acid
increases energy expenditure through enhancing free fatty acid uptake and
β-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle - Mol Nutr
Food Res. 2015 May 5 - "In diet-induced obese rats, 0.5% UA supplementation for
6 weeks markedly reduced body weight, increased energy expenditure, decreased
FFA level in serum and skeletal muscle and triglyceride content in skeletal
muscle ... UA increases FFA burning through enhancing skeletal muscle FFA uptake
and β-oxidation via an UCP3/AMPK-dependent pathway, which provides a novel
perspective on the biological function of UA against obesity and IR" - See ursolic acid at Amazon.com.
-
Strength
vs. endurance: Does exercise type matter in the fight against obesity? -
Science Daily, 4/23/15 - "In addition to the diet,
participants were randomly assigned to follow one of three different types of
exercise training programs or to follow the American College of Sports Medicine
recommendations for weekly physical activity. Subjects assigned to exercise
training groups performed either endurance exercise alone (their choice of
running, elliptical or cycling); strength exercises alone (shoulder press,
squats, barbell row, biceps curl, lateral split, front split, bench press and
French press); or a combination of strength and endurance exercises ... Perhaps
surprisingly, the outcomes for the participants -- including significant
reductions in body weight, body mass index, waist circumference, total fat mass,
and a significant increase in lean mass -- were positive across the board
despite the differences in the type of exercise performed ... One calorie burned
in exercise is not the same as one not ingested"
-
Choice
of protein- and carbohydrate-rich foods may have big effects on long-term weight
gain - Science Daily, 4/9/15 - "diets with a high
glycemic load (GL) from eating refined grains, starches, and sugars were
associated with more weight gain ... Increasing intakes of red meat and
processed meat were most strongly associated with weight gain ... Increasing
intakes of yogurt, seafood, skinless chicken, and nuts were most strongly
associated with weight loss -- the more people ate, the less weight they gained
... Increasing other dairy products, including full-fat cheese, whole milk, and
low-fat milk, did not significantly relate to either weight gain or weight loss
... The fat content of dairy products did not seem to be important for weight
gain ... when people consumed more low-fat dairy products, they actually
increased their consumption of carbs, which may promote weight gain"
-
Rats fed
a dietary fiber supplement had better weight control - Science Daily, 4/8/15
- "Despite having constant access to food high in fat
and sugar, rats given supplemental oligofructose fibre gained about one third
less weight than the control group ... microbiota in obese rats given
oligofructose were changed to be more similar to those of lean animals. Gut
hormones were also affected by the oligofructose, including an increase of a
hormone that helps control the sensation of satiety -- the feeling of being full
... In a 2009 human study that she led, adults receiving supplements of
oligofructose lost on average one kilogram over a 12 week period -- and perhaps
more importantly, didn't continue to gain weight" - See oligosaccharide at Amazon.com.
-
Oxytocin
nasal spray causes men to eat fewer calories - Science Daily, 3/5/15 -
"On average, the men ate 122 fewer calories and 9 grams
less fat at the meal after they received oxytocin nasal spray compared with
placebo ... Oxytocin also reportedly increased the use of body fat as a fuel for
energy. There were no serious side effects and no difference in side effects
between oxytocin and placebo ... Because oxytocin has sex-specific effects, it
needs to be studied in women" - See
Oxy Pro (Oxytocin) Nasal Spray at International Anti-aging Systems.
-
Effects of α-lipoic acid
and eicosapentaenoic acid in overweight and obese women during weight loss -
Obesity (Silver Spring). 2015 Feb;23(2):313-21 - "This is a short-term
double-blind placebo-controlled study with parallel design that lasted 10 weeks.
Of the randomized participants, 97 women received the allocated treatment
[Control, EPA (1.3 g/d), α-lipoic acid (0.3 g/d), and EPA + α-lipoic acid (1.3
g/d + 0.3 g/d)], and 77 volunteers completed the study. All groups followed an
energy-restricted diet of 30% less than total energy expenditure ... Body weight
loss was significantly higher (P < 0.05) in those groups supplemented with
α-lipoic acid. EPA supplementation significantly attenuated (P < 0.001) the
decrease in leptin levels that occurs during weight loss" - [Nutra
USA] - Note: The difference in weight loss was 1.3 kg (2.9 pounds)
over ten weeks. See
fish oil supplements at Amazon.com
and
alpha lipoic acid products at Amazon.com.
-
The effect
of a decaffeinated green tea extract formula on fat oxidation, body composition
and exercise performance - J Int Soc Sports Nutr. 2015 Jan 21;12(1):1 -
"caffeinated green tea (GT) ... decaffeinated green tea
extract (dGTE) ... Participants were randomly assigned capsulated dGTE (571 mg·d(-1);
n = 7) or placebo (PL; n = 7) for 4 weeks ... Body fat significantly decreased
with dGTE by 1.63���± 0.16% in contrast to PL over the intervention period
(P < 0.001; ηp(2) = 0.84). No significant changes for FFA or blood pressure
between groups were observed. dGTE resulted in a 10.9% improvement in
performance distance covered from 20.23 ± 0.54 km to 22.43 ± 0.40 km by week 4
(P < 0.001; ηp(2) = 0.85)" - See
green tea extract at Amazon.com.
-
Resveratrol
induces cell apoptosis in adipocytes via AMPK activation - Biochem Biophys
Res Commun. 2015 Jan 17 - "Our findings clarified the
apoptotic effects and underlying mechanisms of resveratrol in adipocytes,
suggesting its potential therapeutic application in the treatment or prevention
of obesity and related metabolic symptoms" - See
ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count
at Amazon.com.
-
To T3 or Not: Combo Therapy
in Hypothyroidism - Medscape, 12/18/14 - "Patients
treated with desiccated thyroid had an average weight loss of 3 lb, and there
was no difference in thyroid-function blood tests between the two groups after
treatment ... Regarding the theory that it could be dangerous — where are the
case reports of people getting sick? You will not find a single scientific paper
stating any real danger from desiccated thyroid, and as far as I'm concerned,
the [medical societies] are scaring people away from this" - See
thyroid hormones at International Anti-aging Systems (check with your doctor
first).
-
L-carnitine
ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in
patients with metabolic syndrome: a randomized controlled study - Nutr J.
2014 Nov 26;13(1):110 - "In this 7-day, randomized,
single-blind, placebo-controlled, pilot study, 15 metabolic syndrome (MetS)
patients (11/4 F/M; age 46.9 +/- 9.14 years; body mass index [BMI] 28.2 +/- 1.8
kg/m2) were in the L-carnitine group (LC) and 15 (10/5 F/M; age 46.8 +/- 10.9
years; BMI 27.1 +/- 2.3 kg/m2) were in the control group (CT) ... There were
significant differences in weight loss (LC -4.6 +/- 0.9 vs. CT -3.2 +/- 1.1 kg,
P = 0.03), and waist circumference (LC -5.0 +/- 2.2 vs. CT -1.7 +/- 1.16 cm, P <
0.001), waist hip ratio (LC -0.023 +/- 0.017 vs. CT 0.012 +/- 0.01, P < 0.001),
insulin concentration (LC -9.9 +/- 3.58 vs. CT -6.32 +/- 3.44 muU/mL, P =
0.046), and gamma-glutamyltransferase concentration (LC -7.07 +/- 6.82 vs. CT
-2.07 +/- 4.18, P = 0.024). Perceived hunger scores were significantly increased
(P < 0.05) in the CT group during starvation, which was alleviated with
L-carnitine administration in the LC group. Physical fatigue (LC -3.2 +/- 3.17
vs. CT 1.8 +/- 2.04, P < 0.001) and fatigue severity (LC -11.6 +/- 8.38 vs. CT
8.18 +/- 7.32, P < 0.001) were significantly reduced in the LC group but were
aggravated in the CT group" - See
l-carnitine at Amazon.com.
-
Low Serum
Vitamin B-12 and Folate Concentrations and Low Thiamin and Riboflavin Intakes
Are Inversely Associated with Greater Adiposity in Mexican American Children
- J Nutr. 2014 Dec;144(12):2027-2033 - "body adiposity
(BA) ... Similar inverse associations between BA and status of both vitamin B-12
and folate and intake of thiamin and riboflavin suggest that these
micronutrients may play a role in adipogenesis and risk of childhood obesity"
-
Pterostilbene, a molecule similar to resveratrol, as a potential treatment for
obesity - Science Daily, 10/30/14 - "The study conducted in this research is
the first pre-clinical piece of work that analyses the effects of this phenolic
compound on obesity in the animal model. In this model, pterostilbene cuts body
fat due to a reduction in fat synthesis in adipose tissue and an increase in its
oxidation in the liver" - See pterostilbene at Amazon.com.
-
Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight
gain and glucose intolerance in diet-induced obese mice - Benef Microbes.
2014 Dec 1;5(4):437-45 - "Treatment with B. lactis 420 significantly decreased
fat mass in obese (7.83 ± 0.67 g, P=0.007 compared to obese with vehicle) and
diabetic mice (1.89 ± 0.16 g, P=0.02 for highest dose). This was reflected as
reduced weight gain and improved glucose tolerance. Furthermore, B. lactis 420
decreased plasma lipopolysaccharide levels (P<0.001), liver inflammation
(P=0.04), and E. coli adhesion in the distal gut (P<0.05)" - [Nutra
USA] - See Bifidobacterium animalis products at Amazon.com.
-
Green Tea,
Black Tea, and Oolong Tea Polyphenols Reduce Visceral Fat and Inflammation in
Mice Fed High-Fat, High-Sucrose Obesogenic Diets - J Nutr. 2014 Jul 16 -
"Green tea (GT) ... black tea (BT) and oolong tea (OT)
... C57BL/6J mice fed high-fat /high-sucrose [HF/HS (32% energy from fat, 25%
energy from sucrose)] diets ... Treatment with GTPs, OTPs, BTPs, and an LF/HS
diet led to significantly lower body weight, total visceral fat volume by MRI,
and liver lipid weight compared with mice in the HF/HS control group. Only GTPs
reduced food intake significantly by ~10% ... In summary, all 3 tea polyphenol
extracts induced weight loss and anti-inflammatory and angiogenic effects,
although the tissue content of polyphenol differed significantly" - See
green tea extract at Amazon.com.
-
Yogurt
consumption, weight change and risk of overweight/obesity: The SUN cohort study
- Nutr Metab Cardiovasc Dis. 2014 Jun 15 - "Participants
were classified in 5 categories of yogurt consumption at baseline: 0-2, >2-<5,
5-<7, 7 and ≥7 servings/week. Outcomes were: 1) average yearly weight change
during follow-up; and 2) incidence of overweight/obesity. Linear regression
models and Cox models were used to adjust for potential confounders. After a
median follow-up of 6.6 years, 1860 incident cases of overweight/obesity were
identified. A high (>7 servings/week) consumption of total and whole-fat yogurt
was associated with lower incidence of overweight/obesity [multivariable
adjusted hazard ratios = 0.80 (95% CI: 0.68-0.94); and 0.62 (0.47-0.82)
respectively] in comparison with low consumption (0-2 servings/week). This
inverse association was stronger among participants with higher fruit
consumption"
-
Vitamin
D can lower weight, blood sugar via the brain, study finds - Science Daily,
6/23/14 - "Compared with the control rats, animals that
received vitamin D had improved glucose tolerance, which is how the body
responds to sugar. In a separate experiment, these treated rats also had greatly
improved insulin sensitivity, the body's ability to successfully respond to
glucose. When this ability decreases -- called insulin resistance -- it
eventually leads to high blood sugar levels. Two of insulin's main effects are
to clear glucose from the bloodstream and decrease glucose production in the
liver. In this study, vitamin D in the brain decreased the glucose created by
the liver ... In a separate experiment of long-term vitamin D treatment, the
researchers gave three rats vitamin D and four rats vehicle alone for four
weeks. They observed a large decrease in food intake and weight in rats
receiving vitamin D compared with the group that did not get vitamin D. Over 28
days, the treated group ate nearly three times less food and lost 24 percent of
their weight despite not changing the way they burned calories"
- See
vitamin D at Amazon.com.
-
Fish or
n3-PUFA intake and body composition: a systematic review and meta-analysis -
Obes Rev. 2014 May 29 - "we performed a systematic
review of randomized controlled trials and the first meta-analysis on the
association between fish or fish oil intake and body composition measures. We
found evidence that participants taking fish or fish oil lost 0.59 kg more body
weight than controls (95% confidence interval [CI]: -0.96 to -0.21). Treatment
groups lost 0.24 kg m-2 (body mass index) more than controls (-0.40 to -0.08),
and 0.49 % more body fat than controls (-0.97 to -0.01). Fish or fish oil
reduced waist circumference by 0.81 cm (-1.34 to -0.28) compared with control"
- See
fish oil supplements at Amazon.com.
-
Diabetics: Two large meals better than 6 small meals with same calories for
controlling weight, blood sugar - Science Daily, 5/15/14 -
"They were asked to follow one of two regimens of a
restricted calorie diet, each containing 500 calories less than the recommended
daily amount; in one programme the meals were six small meals (A6) and the other
2 large meals, breakfast and lunch (B2) ... The diet in both regimens had the
same macronutrient and calorie content ... body weight decreased in both
regimens, more for B2 (-3.7kg) than for A6 (-2.3kg). Liver fat content decreased
in response to both regimens, more for B2 (-0.04%) than for A6 (-0.03%). Fasting
plasma glucose and C-peptide levels decreased in both regimens, again more for
B2. Fasting plasma glucagon (the hormone that converts glycogen back to glucose)
decreased with the B2 regimen, whereas it increased for the A6 regimen. Oral
glucose insulin sensitivity (OGIS) increased in both regimens, more for B2"
-
Why
exercise may not help obese shed much weight: Exercise can elevate stress
response and make it more difficult to become slim - Science Daily, 5/12/14
- "The research covered 17 inactive people with a body
mass index greater than 35 who took part in a 22 week programme for lifestyle
change which involved exercise, diet and seminars ... Despite their efforts, the
participants lost less weight than expected from the amount of keep-fit they did
and the changes they made to their eating habits ... The scientists believe this
could be related to cortisol ... those participants who lost the most weight had
the lowest level of morning cortisol"
-
Effects of
whey protein and resistance exercise on body composition: a meta-analysis of
randomized controlled trials - J Am Coll Nutr. 2014 Apr;33(2):163-75 -
"A comprehensive literature search was conducted to
identify RCTs that investigated WP (concentrate, isolate, or hydrolystate) and
body weight, body mass index (BMI), body fat, lean body mass (LBM), fat-free
mass (FFM), and waist circumference ... Body weight (WGMD: -4.20 kg, 95%
confidence interval [CI], -7.67, -0.73) and body fat (WGMD: -3.74 kg, 95% CI,
-5.98, -1.50) were significantly decreased from baseline in the WPR within-group
analyses ... Results from the subgroup analyses indicated a statistically
significant increase in LBM (WGMD: 2.24 kg, 95% CI, 0.66, 3.81) among studies
that included a resistance exercise component along with WP provision" -
Note: 4.20 kg is 9.3 pounds. See
whey protein at Amazon.com.
-
Association
of urinary sodium-to-potassium ratio with obesity in a multiethnic cohort -
Am J Clin Nutr. 2014 Feb 19 - "2782 participants in the
community-dwelling, probability-sampled, multiethnic Dallas Heart Study were
analyzed. The primary outcome established a priori was total-body percentage fat
(TBPF) measured by dual-energy X-ray absorptiometry ... TBPF increased by 0.75
(95% CI: 0.25, 1.25) and 0.43 (0.15, 0.72), respectively (P = 0.003 for both),
for every 3-unit increase in U[Na+]/[K+] ... The ratio of dietary Na+ to K+
intake may be independently associated with TBPF, and this association may be
more pronounced in non-African Americans" - See
potassium citrate at Amazon.com.
-
7 Weird Reasons You're Gaining Weight - ABC News, 2/4/14 - "You're
depressed ... You're taking the wrong Rx ... Your gut is slow ... Your body's
missing certain nutrients ... You're getting older ... You have plantar
fasciitis ... You have Cushing's Syndrome"
-
Certain
probiotics could help women lose weight, study finds - Science Daily,
1/28/14 - "researchers recruited 125 overweight men and
women ... half the participants swallowed 2 pills daily containing probiotics
from the Lactobacillus rhamnosus family, while the other half received a placebo
... After the 12-week diet period, researchers observed an average weight loss
of 4.4 kg in women in the probiotic group and 2.6 kg in the placebo group.
However, no differences in weight loss were observed among males in the two
groups ... We don't know why the probiotics didn't have any effect on men. It
may be a question of dosage, or the study period may have been too short"
- Note: 4.4 kg is 9.7 pounds. See
probiotic products at Amazon.com.
-
The microbes in your gut may be making you fat or keeping you thin - The
Washington Post, 12/6/13 - "naturally occurring bacteria
and other microbes in the body, and possibly even viruses, can influence weight
in ways that scientists are only just beginning to understand ... Studies in
mice have shown that intestinal microbes may contribute to weight gain. A novel
experiment published this fall, for example, took gut bacteria from human twins
— in which one was lean and the other obese — and transferred them into lean
mice. The animals with bacteria from fat twins grew fat; those that received
bacteria from lean twins stayed lean" - See
probiotic products at Amazon.com.
-
The 10 Most Filling Foods for Weight Loss - ABC News, 12/10/13 -
"Baked potato ... Eggs ... Bean soup ... Greek yogurt
... Apples ... Popcorn ... Figs ... Oatmeal ... Wheat berries ... Smoothies"
-
Effect of
Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and
maintenance in obese men and women - Br J Nutr. 2013 Dec 3:1-13 -
"The present study investigated the impact of a
Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation on weight loss and
maintenance in obese men and women over 24 weeks ... The intention-to-treat
analysis showed that after the first 12 weeks and after 24 weeks, mean weight
loss was not significantly different between the LPR and placebo groups when all
the subjects were considered. However, a significant treatment × sex interaction
was observed. The mean weight loss in women in the LPR group was significantly
higher than that in women in the placebo group (P= 0.02) after the first 12
weeks, whereas it was similar in men in the two groups (P= 0.53). Women in the
LPR group continued to lose body weight and fat mass during the
weight-maintenance period, whereas opposite changes were observed in the placebo
group. Changes in body weight and fat mass during the weight-maintenance period
were similar in men in both the groups. LPR-induced weight loss in women was
associated not only with significant reductions in fat mass and circulating
leptin concentrations but also with the relative abundance of bacteria of the
Lachnospiraceae family in faeces. The present study shows that the Lactobacillus
rhamnosus CGMCC1.3724 formulation helps obese women to achieve sustainable
weight loss" - See
Garden of Life, Primal Defense at Amazon.com which includes Lactobacillus rhamnosus.
-
Melatonin Helps Control Weight Gain as It Stimulates the Appearance of ‘beige
Fat’ That Can Burn Calories Instead of Storing Them, Study Suggests -
Science Daily, 9/25/13 - "chronic administration of
melatonin sensitizes the thermogenic effect of exposure to cold, heightens the
thermogenic effect of exercise and, therefore, constitutes excellent therapy
against obesity. The fact is that one of the key differences between 'beige
fat', which appears when administering melatonin, and 'white fat', is that
'beige fat' cell mitochondria express levels of UCP1 protein, responsible for
burning calories and generating heat" - See
melatonin at Amazon.com.
-
Gut Bacteria From Thin Humans Can Slim Mice Down - NYTimes.com, 9/5/13 -
"Researchers found pairs of human twins in which one was
obese and the other lean. They transferred gut bacteria from these twins into
mice and watched what happened. The mice with bacteria from fat twins grew fat;
those that got bacteria from lean twins stayed lean ... The investigators
discovered that given a chance, and in the presence of a low-fat diet, bacteria
from a lean twin will take over the gut of a mouse that already had bacteria
from a fat twin. The fat mouse then loses weight. But the opposite does not
happen. No matter what the diet, bacteria from a fat mouse do not take over in a
mouse that is thin ... The fat mice that got food high in fat and low in fruits
and vegetables kept the gut bacteria from the fat twins and remained fat. The
thin twins’ gut bacteria only took over when the mice got pellets that were rich
in fruits and vegetables and low in fat" - [WebMD
/
ABC News] - See
Garden of Life, Primal Defense at Amazon.com.
-
Why
Smokers Gain Weight When They Quit Smoking: Changes in Intestinal Flora -
Science Daily, 8/29/13 - "the Swiss IBD cohort study
examined the genetic material of intestinal bacteria found in the faeces and
studied stool samples which they had received from twenty different persons over
a period of nine weeks -- four samples per person. The test persons included
five non-smokers, five smokers and ten persons who had quit smoking one week
after the start of the study ... While the bacterial diversity in the faeces of
smokers and non-smokers changed only little over time, giving up smoking
resulted in the biggest shift in the composition of the microbial inhabitants of
the intestines. The Proteobacteria and Bacteroidetes fractions increased at the
expense of representatives of the Firmicutes and Actinobacteria phyla. At the
same time, the test subjects who had quit smoking gained an average of 2.2 kilos
in weight although their eating and drinking habits remained the same ... Their
results reflected those seen in previous studies conducted with mice" -
See
Garden of Life, Primal Defense at Amazon.com
and also my yogurt recipe.
-
Obesity
and diabetes risk: One in four has alarmingly few intestinal bacteria, Danish
study finds - Science Daily, 8/28/13 - "Oluf
Pedersen compares the human gut and its bacteria with a tropical rainforest. He
explains that we need as much diversity as possible, and -- as is the case with
the natural tropical rainforests -- decreasing diversity is a cause for concern.
It appears that the richer and more diverse the composition of our
intestinal bacteria, the stronger our health. The
bacteria produce vital vitamins, mature and strengthen our immune system and
communicate with the many nerve cells and hormone-producing cells in the
intestinal system. And, not least, the bacteria produce a wealth of bioactive
substances which penetrate into the bloodstream and affect our biology in
countless ways ... people having few and less diverse intestinal bacteria are
more obese than the rest. They have a preponderance of bacteria which exhibit
the potential to cause mild inflammation in the digestive tract and in the
entire body, which is reflected in blood samples that reveal a state of chronic
inflammation, which we know from other studies to affect metabolism and increase
the risk of type 2 diabetes and cardiovascular
diseases" - See
Garden of Life, Primal Defense at Amazon.com
and also my yogurt recipe.
-
Eating a
big breakfast fights obesity and disease - Science Daily, 8/5/13 -
"Metabolism is impacted by the body's circadian rhythm
-- the biological process that the body follows over a 24 hour cycle. So the
time of day we eat can have a big impact on the way our bodies process food ...
93 obese women were randomly assigned to one of two isocaloric groups. Each
consumed a moderate-carbohydrate, moderate-fat diet totaling 1,400 calories
daily for a period of 12 weeks. The first group consumed 700 calories at
breakfast, 500 at lunch, and 200 at dinner. The second group ate a 200 calorie
breakfast, 500 calorie lunch, and 700 calorie dinner ... By the end of the
study, participants in the "big breakfast" group had lost an average of 17.8
pounds each and three inches off their waist line, compared to a 7.3 pound and
1.4 inch loss for participants in the "big dinner" group ... those in the big
breakfast group were found to have significantly lower levels of the
hunger-regulating hormone ghrelin"
-
Dietary supplementation with purified mulberry (Morus australis Poir)
anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice -
Food Chem. 2013 Nov 1 - "Three kinds of anthocyanins
(cyanidin-3-glucoside, cyanidin-3-rutinoside and pelargonidin-3-glucoside)
purified from Chinese mulberry (Morus australis Poir) were evaluated for
suppressing body weight gain of the male C57BL/6 mice fed with high-fat diet
(HFD). The results from a 12-week experiment show that consumption of purified
mulberry anthocyanins (MACN) of 40 or 200mg/kg can significantly inhibit body
weight gain, reduce the resistance to insulin, lower the size of adipocytes,
attenuate lipid accumulation and decrease the leptin secretion. Thus, dietary
supplementation with MACN can protect against body weight gain of the
diet-induced obese mice" - [Nutra
USA] - See PGX at Amazon.com.
-
Predictors
of increased body weight and waist circumference for middle-aged adults -
Public Health Nutr. 2013 May 1:1-11 - "Prospective
cohort study, the Melbourne Collaborative Cohort Study (MCCS), with data at
baseline (1990-1994) and wave 2 (2003-2007) ... Our findings indicate that
promoting vigorous physical activity, encouraging a diet high in carbohydrate
and fibre but low in fat and protein, and limiting alcohol intake could be
promising approaches for preventing obesity in middle-aged adults"
-
Protein-rich breakfasts prevent unhealthy snacking in the evening, study finds
- Science Daily, 3/26/13 - "20 overweight or obese
adolescent females ages 18-20 either skipped breakfast, consumed a high-protein
breakfast consisting of eggs and lean beef, or ate a normal-protein breakfast of
ready-to-eat cereal. Every breakfast consisted of 350 calories and was matched
for dietary fat, fiber, sugar and energy density. The high-protein breakfast
contained 35 grams of protein ... The consumption of the high-protein breakfast
led to increased fullness or "satiety" along with reductions in brain activity
that is responsible for controlling food cravings. The high-protein breakfast
also reduced evening snacking on high-fat and high-sugar foods compared to when
breakfast was skipped or when a normal protein, ready-to-eat cereal breakfast
was consumed ...Study participants ate egg and beef-based foods such as burritos
or egg-based waffles with applesauce and a beef sausage patty as part of a
high-protein breakfast; Leidy also suggests eating plain Greek yogurt, cottage
cheese or ground pork loin as alternatives to reach the 35 grams of protein"
-
Chromium
supplementation in overweight and obesity: a systematic review and meta-analysis
of randomized clinical trials - Obes Rev. 2013 Mar 18 -
"Electronic searches were conducted in Medline, Embase,
Amed and The Cochrane Library ... A meta-analysis of 11 studies showed a
statistically significant difference in weight loss favouring chromium over
placebo (mean difference (MD): -0.50 kg; 95% confidence interval (CI): -0.97,
-0.03). There was a high statistical heterogeneity. Adverse events included
watery stools, vertigo, headaches and urticaria. The evidence from available
RCTs shows that chromium supplementation generates statistically significant
reductions in body weight" - See
chromium supplements at Amazon.com.
-
Olive
Oil Makes You Feel Full - Science Daily, 3/14/13 -
"While it is true that they contain fewer calories, people tend to
overcompensate by eating more if they do not feel full. Now a study has shown
how "natural" oils and fats regulate the sensation of feeling full after eating,
with olive oil leading the way ...Over a period of three months, the study
participants ate 500 grams of low-fat yoghurt enriched with one of the four fats
or oils every day -- as a supplement to their normal diet ... The olive oil
group showed a higher concentration of the satiety hormone serotonin in their
blood. Subjectively speaking, these participants also reported that they found
the olive oil yoghurt very filling ... During the study period, no member of
this group recorded an increase in their body fat percentage or their weight ...
How long the feeling of satiety lasts after eating depends on a number of
factors, but blood sugar level is particularly significant. The faster it falls,
that is to say, the faster the somatic cells absorb glucose from the blood, the
sooner the person will start to feel hungry again"
-
Lose fat
faster before breakfast - Science Daily, 1/25/13 -
"those who had exercised in the morning did not consume additional calories or
experience increased appetite during the day to compensate for their earlier
activity ... They also found that those who had exercised in a fasted state
burned almost 20% more fat compared to those who had consumed breakfast before
their workout. This means that performing exercise on an empty stomach provides
the most desirable outcome for fat loss"
-
Carbs at night can help you lose weight - Today Health, 1/20/13 -
"In the study, researchers split 78 Israeli police
officers into two groups and placed them on nearly identical 6-month-long
low-calorie diets (1,300 to 1,500 calories a day) eating equal amount of carbs,
protein, and fat throughout the day. The only difference: Half of the officers
ate the majority of their carbs at night while the other half ate them
throughout the day. At the start and end of the study, researchers analyzed
blood hormone levels while the cops recorded their hunger levels ... Nighttime
carb eaters lost 27 percent more body fat than people on the standard diet.
Surprisingly, they also felt 13.7 percent fuller at the end of the study than
the beginning, while regular dieters were hungrier. What's more, the level of
inflammatory hormones -- which can lead to heart disease and cancer -- in the
nighttime group's blood decreased by 27.8 percent compared to only 5.8 percent
in the standard dieters" - Note: So maybe carbs at night and eggs in the
morning might be a strategy:
-
Eggs at Breakfast May Delay Hunger - WebMD, 5/11/12 -
"researchers tracked 20 overweight or obese people,
giving them either a breakfast containing eggs or cold cereal for one week.
Although the breakfasts offered different protein foods, the meals themselves
were equally matched in terms of calories, carbohydrates, protein, and fat ...
people who had eggs in the morning felt fuller before lunch, and they also ate
less food from the buffet compared to those who had cereal. Egg eaters also had
lower levels of ghrelin and higher amounts of PYY3-36 during the three hours
between breakfast and lunch. This suggests they felt less hungry and more
satisfied between meals ... Long-term weight loss trials to compare the
manipulation of protein quality without increasing protein quantity should be
explored"
-
Higher-protein diet for weight management in young overweight women: a 12 month
randomised controlled trial - Diabetes Obes Metab. 2012 Dec 26 -
"This randomised controlled trial compared the efficacy
of two iso-energetically restricted (5600kJ) diets (HP: 32% protein, 41%
carbohydrate, 25% fat or HC: 20, 58, 21% respectively) in 71 (HP:n=36; HC:n=35)
young healthy women (18-25y; BMI≥27.5kg/m(2) ) for weight (kg; percent weight
loss), body composition, metabolic and iron changes assessed at baseline, six
and 12 months ... No significant between-diet differences were observed at 12
months. Biochemistry remained within normal ranges with HP showing superior
preservation of ferritin at six months (HP:53(40-66); HC:46(30-61)µg/L;
p=0.029). Both diets supported clinically meaningful weight loss with HP tending
to be more effective in the medium-term"
-
Aerobic
exercise trumps resistance training for weight and fat loss - Science Daily,
12/15/12 - "Participants were randomly assigned to one
of three exercise training groups: resistance training (three days per week of
weight lifting, three sets per day, 8-12 repetitions per set), aerobic training
(approximately 12 miles per week), or aerobic plus resistance training (three
days a week, three set per day, 8-12 repetitions per set for resistance
training, plus approximately 12 miles per week of aerobic exercise) ... The
groups assigned to aerobic training and aerobic plus resistance training lost
more weight than those who did just resistance training. The resistance training
group actually gained weight due to an increase in lean body mass ... The
combination exercise group, while requiring double the time commitment, provided
a mixed result. The regimen helped participants lose weight and fat mass, but
did not significantly reduce body mass nor fat mass over aerobic training alone.
This group did notice the largest decrease in waist circumference, which may be
attributed to the amount of time participants spent exercising ... Balancing
time commitments against health benefits, our study suggests that aerobic
exercise is the best option for reducing fat mass and body mass"
-
Low fat
diet is key to a slimmer figure, study suggests - Science Daily, 12/6/12 -
"Exchanging fatty foods for lower fat alternatives will
help people shift around three-and-a-half pounds -- without any other form of
dieting. People taking part in trials also saw their waist-lines become slimmer,
and levels of bad cholesterol decrease ... The results show that eating less fat
reduces body weight by 1.6kg, BMI by 0.56kg/m² and waist circumference by 0.5cm.
All these effects were in trials in which weight loss was not the intended
outcome, suggesting that they occur in people with normal diets. The weight loss
happened quickly and was maintained over at least seven years"
-
Could
high insulin make you fat? Mouse study says yes - Science Daily, 12/4/12 -
"When we eat too much, obesity may develop as a result
of chronically high insulin levels, not the other way around ... The new study
helps to solve this chicken-or-the-egg dilemma by showing that animals with
persistently lower insulin stay trim even as they indulge themselves on a
high-fat, all-you-can-eat buffet ... the researchers produced mice that varied
only in their fasting blood insulin levels. When presented with high-fat food,
those with one copy and lower fasting insulin were completely protected from
obesity even without any loss of appetite. They also enjoyed lower levels of
inflammation and less fat in their livers, too ... the researchers produced mice
that varied only in their fasting blood insulin levels. When presented with
high-fat food, those with one copy and lower fasting insulin were completely
protected from obesity even without any loss of appetite. They also enjoyed
lower levels of inflammation and less fat in their livers, too"
-
Changes in
bread consumption and 4-year changes in adiposity in Spanish subjects at high
cardiovascular risk - Br J Nutr. 2012 Dec 3:1-10 -
"We analysed 2213 participants at high risk for CVD from the PREvención con
DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in
the consumption of bread and weight and waist circumference gain over time.
Dietary habits were assessed with validated FFQ at baseline and repeatedly every
year during 4 years of follow-up ... The present results showed that over 4
years, participants in the highest quartile of change in white bread intake
gained 0.76 kg [1.7 pounds] more than those in the lowest quartile (P for trend
= 0.003) and 1.28 cm [0.5 inches] more than those in the lowest quartile (P for
trend < 0.001) ... The present results suggest that reducing white bread, but
not whole-grain bread consumption, within a Mediterranean-style food pattern
setting is associated with lower gains in weight and abdominal fat"
-
New
research: Limiting carbs to dinner-time increases satiety, reduces risk for
diabetes and cardiovascular disease - Science Daily, 11/11/12 -
"randomly assigned 78 police officers to either the
experimental diet (carbohydrates at dinner) or a control weight loss diet
(carbohydrates throughout the day). 63 subjects finished the six-month program
... researchers examined the experimental diet's effect on the secretion of
three hormones: leptin, considered to be the satiety hormone, whose level in the
blood is usually low during the day and high during the night; ghrelin,
considered the hunger hormone, whose level in the blood is usually high during
the day and low during the night; and adiponectin, considered the link between
obesity, insulin resistance and the metabolic syndrome, whose curve is low and
flat in obese people ... the innovative dietary manipulation led to changes in
daylight hormonal profiles in favor of the dieters: the satiety hormone leptin's
secretion curve became convex during daylight hours with a nadir in the late
day; the hunger hormone ghrelin's secretion curve became concave, peaking only
in the evening hours; and the curve of adiponectin, considered the link between
obesity, insulin resistance and the metabolic syndrome, was elevated. At the
same time this dietary pattern led to lower hunger scores, and better
anthropometric (weight, abdominal circumference and body fat), biochemical
(blood sugar, blood lipids) and inflammatory outcomes compared to the control
group"
-
Effect of
green tea (camellia sinensis) consumption on the components of metabolic
syndrome in elderly - J Nutr Health Aging. 2012;16(9):738-42 -
"The consumption of green tea was effective in inducing
weight loss, reducing BMI and waist circumference in the elderly with MS"
- See
green tea extract at Amazon.com.
-
Soups increase satiety
through delayed gastric emptying yet increased glycaemic response - Eur J
Clin Nutr. 2012 Oct 24 - "A total of 12 volunteers were
tested on three occasions after a solid meal, chunky soup or smooth soup test
meal for gastric emptying (GE) ... glycaemic response (GR) ... The smooth soup
had the greatest GR (87.0+/-49.5 mmol/l/min), followed by the chunky soup
(65.4+/-48.0 mmol/l/min), with the solid meal having the lowest GR
(61.6+/-36.8 mmol/l/min). Volunteers were fuller after the smooth soup compared
with solid meal (P=0.034). The smooth soup induced greater fullness compared
with the solid meal because of a combination of delayed GE leading to feelings
of gastric distension and rapid accessibility of nutrients causing a greater
glycaemic response" - Note: I was flipping through the channels a couple
weeks ago and on one of the major networks was a dietician recommending soup as
a major contribution to satiety.
-
Regulation
of brown adipose tissue development and white fat reduction by L-arginine -
Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):529-38 -
"Brown adipose tissue (BAT), which is present in humans, plays an important role
in oxidation of fatty acids and glucose ... L-arginine increases mammalian BAT
growth and development via mechanisms involving gene expression, nitric oxide
signaling, and protein synthesis. This enhances the oxidation of energy
substrates and, thus, reduces white fat accretion in the body. L-arginine holds
great promise in preventing and treating obesity in humans" - See
L-arginine products at Amazon.com.
-
Effect of DHEA-S on
Metabolic Syndrome in Obese Women: Abstract and Introduction - Medscape,
10/12/12 - "Dehydroepiandrosterone-sulphate replacement
produced weight loss in the obese women studied. Moreover, waist circumference,
glucose and systolic and diastolic blood pressure, among other metabolic
syndrome parameters, improved in the postmenopausal group, who showed a
significant reduction in the total metabolic syndrome score (P < 0.05). In
contrast, in premenopausal women, the effect of DHEA-S was limited to obesity
parameters, and no effect was observed on metabolic syndrome components. No
significant changes were evident in the placebo group" - See
DHEA at Amazon.com.
-
Apple
peel compound boosts brown fat, reduces obesity in mice - Science Daily,
6/20/12 - "The findings suggest that the substance known
as ursolic acid reduces obesity and its associated health problems by increasing
the amount of muscle and brown fat, two tissues recognized for their
calorie-burning properties ... In this study, we tested ursolic acid in mice on
a high-fat diet -- a mouse model of obesity and metabolic syndrome. Once again,
ursolic acid increased skeletal muscle. Interestingly, it also reduced obesity,
pre-diabetes and fatty liver disease ... Since muscle is very good at burning
calories, the increased muscle in ursolic acid-treated mice may be sufficient to
explain how ursolic acid reduces obesity. However, we were surprised to find
that ursolic acid also increased brown fat, a fantastic calorie burner. This
increase in brown fat may also help protect against obesity" - See
ursolic acid at Amazon.com.
-
Eggs at Breakfast May Delay Hunger - WebMD, 5/11/12 -
"researchers tracked 20 overweight or obese people,
giving them either a breakfast containing eggs or cold cereal for one week.
Although the breakfasts offered different protein foods, the meals themselves
were equally matched in terms of calories, carbohydrates, protein, and fat ...
people who had eggs in the morning felt fuller before lunch, and they also ate
less food from the buffet compared to those who had cereal. Egg eaters also had
lower levels of ghrelin and higher amounts of PYY3-36 during the three hours
between breakfast and lunch. This suggests they felt less hungry and more
satisfied between meals ... Long-term weight loss trials to compare the
manipulation of protein quality without increasing protein quantity should be
explored" - Note: I fully agree. I just seems very easy to keep my
weight in check when I have eggs for breakfast.
-
Metformin-based treatment for obesity-related hypertension: a randomized,
double-blind, placebo-controlled trial - J Hypertens. 2012 Apr 19 -
"metformin (500 mg once per day) or placebo ... At 24
weeks, metformin compared with placebo did not have significant effects on blood
pressure, blood glucose, high-density or low-density lipoprotein cholesterol,
but it did reduce total serum cholesterol (0.27mmol/l, P = 0.038). Metformin
also significantly reduced weight (-0.7 kg, P���= 0.006), BMI (-0.2���kg/m,
P = 0.024), waist circumference (-0.9 cm, P = 0.008), and both subcutaneous
(-6.1 cm, P = 0.043) and visceral adiposity (-5.4 cm, P = 0.028) as measured by
computed tomography, and lowered serum high-sensitivity C-reactive protein
levels (-0.6 mg/dl, P < 0.001). There was no significant difference in adverse
events" - See
metformin at The Antiaging Store.
-
Potential method to control obesity: Red wine, fruit compound could help block
fat cell formation - Science Daily, 4/4/12 - "A
compound found in red wine, grapes and other fruits, and similar in structure to
resveratrol, is able to block cellular processes that allow fat cells to
develop, opening a door to a potential method to control obesity ... the
compound piceatannol blocks an immature fat cell's ability to develop and grow
... piceatannol binds to insulin receptors of immature fat cells in the first
stage of adipogenesis, blocking insulin's ability to control cell cycles and
activate genes that carry out further stages of fat cell formation. Piceatannol
essentially blocks the pathways necessary for immature fat cells to mature and
grow" - See
grape seed extract at Amazon.com.
-
Coffee Bean Extract Linked to Weight Loss - ABC News, 3/27/12 -
"Researchers gave up to 1,050 milligrams of green coffee
bean extract to 16 overweight adults in their 20s and monitored their diet,
exercise regimen, weight, heart rate and blood pressure for 22 weeks. Without
changing their diet or exercise, study subjects lost roughly 10.5 percent — an
average of 17 pounds – in overall body weight. No harmful side effects were
noted ... How green coffee bean extract contributes to weight loss is unclear.
But Vinson theorizes a chemical in the unroasted bean called chlorogenic acid
could be responsible" - See
green coffee bean extract at Amazon.com.
-
Clinical trial supports CLA’s weight management in obese Chinese - Nutra
USA, 2/17/12 - "Twelve weeks of supplementation produced
an average 0.7 kg decrease in body weight and an average decrease in total body
fat of 0.6 kg ... milk supplemented with CLA (3.4 g/d for 12 wk) ... used the
Tonalin branded ingredient from BASF" - [Abstract]
- See
conjugated linoleic acid at Amazon.com.
-
Lack of
sleep makes your brain hungry - Science Daily, 1/18/12 -
"a specific brain region that contributes to a person's
appetite sensation is more activated in response to food images after one night
of sleep loss than after one night of normal sleep. Poor sleep habits can
therefore affect people's risk of becoming overweight in the long run"
-
Diet Plans That Work - US News Best
Diets - US News and World Report, 1/4/12 - "Best
Diets Overall ... DASH Diet ... TLC Diet ... Best Weight-Loss Diets ... Weight
Watchers ... Best Diabetes Diets ... Biggest Loser Diet ... Biggest Loser Diet
... DASH Diet ... Best Heart-Healthy Diets ... Ornish Diet ... TLC Diet"
-
Evaluation
of the usefulness of a low-calorie diet with or without bread in the treatment
of overweight/obesity - Clin Nutr. 2011 Dec 30 -
"The aim of this study was to compare two nutrition strategies (with or without
bread) designed to promote weight loss in overweight/obese women ... 104 women
completed the study (48.4 +/- 9 years, 29.8 +/- 3.5 kg/m(2)). Anthropometric and
biochemical markers improved after the intervention without significant
differences between groups. BREAD group significantly increased total cereal
consumption (3.2 +/- 1.3 to 3.7 +/- 0.5 servings/day, P < 0.05) and the
percentage of energy from carbohydrates (41.2 +/- 6.4 vs. 45.9 +/- 5.0% P <
0.001) and reduced fat (39.0 +/- 6.6 vs. 32.7 +/- 5.1% P < 0.001). In contrast,
NO BREAD group increased the discrepancy with recommended consumption. NO BREAD
group had the most dropouts (21.3% vs. 6.6%, P < 0.05) ... The bread inclusion
in a low-calorie diet designed for weight loss favoured a better evolution of
dietetic parameters and greater compliance with the diet with fewer dropouts"
-
Diferential
Effect of Oral Dehydroepiandrosterone-Sulphate on Metabolic Syndrome Features in
Pre- and Postmenopausal Obese Women - Clin Endocrinol (Oxf). 2011 Dec 2 -
"To analyze the effect in obese pre- and postmenopausal
women of a daily dose of 100 mg Dehydroepiandrosterone-sulphate (DHEA-S)
provided over a period of 3 months as replacement therapy against
Metabolic-Syndrome ... DHEA-S replacement produced weight loss in the obese
women studied. Moreover, waist-circumference, glucose and systolic and diastolic
blood pressure, among other Metabolic-Syndrome parameters, improved in the
postmenopausal group, who showed a significant reduction in the total
Metabolic-Syndrome Score (P<0.05). In contrast, in premenopausal women, the
effect of DHEA-S was limited to obesity parameters and no effect was observed on
Metabolic-Syndrome components. No significant changes were evident in the
placebo group. Conclusions: An oral dose of DHEA-S is useful for weight loss.
In obese postmenopausal women the hormone significantly improves plasma
biochemical levels and anthropometric characteristics, leading to a better
metabolic profile, which highlights the usefulness of this therapy against
Metabolic-Syndrome in this group of women" - See
DHEA at Amazon.com.
-
Korean Red
Ginseng (Panax ginseng) Improves Insulin Sensitivity in High Fat Fed
Sprague-Dawley Rats - Phytother Res. 2011 Oct 28 -
"Many studies have documented that ginseng has antidiabetic and antiobesity
effects, but the mechanism of the effects has not been elucidated. The aim of
this study was to determine the effect of Korean red ginseng (KRG, Panax
ginseng) and investigate the mechanism of antidiabetic and antiobesity effects
in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided
into three groups: a control group (group I) fed a normal diet, another group
(group II) fed only high fat diet (HFD) and a third group (group III) fed HFD
with KRG (200 mg/kg, oral) for 18 weeks ... A significant weight reduction,
especially fat mass reduction, was observed in the KRG treated group. Increased
insulin sensitivity was found in the KRG treated group. We observed increased
insulin signalling, increased phosphorylation of IR, IRS-1, Akt, and membranous
GLUT4 in muscle by Western blotting assay. In conclusion, KRG may have
antidiabetic and antiobesity effects due to partly increased insulin sensitivity
by increased adipokine and partly enhanced insulin signalling" - See
ginseng at Amazon.com.
-
Watching Your Protein May Be Key to Weight Control - WebMD, 10/12/11 -
"men and women fed a 10% protein diet ate 12% more
calories over four days than they did on a 15% protein diet ... When protein in
the diet goes too low, ''We keep eating in an attempt to attain our target level
of protein," ... As the protein declined to 10%, the men and women tended to eat
more carbohydrates and fat-containing food, boosting the risk for weight gain.
But Gosby found that increasing the protein from 15% to 25% didn't seem to make
any difference in total calories eaten ... Aiming at 15%-25% of total energy
intake as protein seems about right for a moderately active person" - [Science
Daily]
-
Green
tea helps mice keep off extra pounds - Science Daily, 10/4/11 -
"in the current online version of Obesity, fed two
groups of mice a high-fat diet. Mice that were fed Epigallocatechin-3-gallate --
EGCG -- a compound found in most green teas, along with a high-fat diet, gained
weight 45 percent more slowly than the control group of mice eating the same
diet without EGCG ... In addition to lower weight gain, the mice fed the green
tea supplement showed a nearly 30 percent increase in fecal lipids, suggesting
that the EGCG was limiting fat absorption ... A person would need to drink ten
cups of green tea each day to match the amount of EGCG used in the study"
- See
green tea extract at Amazon.com.
-
Soluble fiber may help shed 1.5kg in 12 weeks: Roquette study - Nutra USA,
9/16/11 - "One hundred and twenty overweight men were
randomly assigned to consume fruit juice supplemented with 17 grams of either
Nutriose or maltodextrin (control) for 12 weeks. The participants consumed the
juice twice a day to provide a daily dose of 34 grams ... men who drank the
Nutriose beverage had an average body weight loss of 1.5 kg, an average body
mass index (BMI) reduction of 0.5 kg/m2, and lost an average of 0.3% of their
body fat percentage, compared with the control group ... In addition, men who
drank the Nutriose-supplemented drink reported less hunger across the study
period, compared with men in the control group"[Abstract]
- Note: 1.5 kg = 3.3 lbs - See Jarrow Formulas, Fiber Perfect at Amazon.com
(It contains the Nutriose).
-
Foods
rich in protein, dairy products help dieters preserve muscle and lose belly fat
- Science Daily, 8/29/11 - "a higher-protein,
lower-carbohydrate energy-restricted diet has a major positive impact on body
composition, trimming belly fat and increasing lean muscle, particularly when
the proteins come from dairy products ... compared three groups of overweight
and obese, but otherwise healthy, premenopausal women. Each consumed either low,
medium or high amounts of dairy foods coupled with higher or lower amounts of
protein and carbohydrates ... there were identical total weight losses among the
groups, but the higher-protein, high-dairy group experienced greater whole-body
fat and abdomen fat losses, greater lean mass gains and greater increases in
strength ... One hundred per cent of the weight lost in the higher-protein,
high-dairy group was fat. And the participants gained muscle mass, which is a
major change in body composition ... the lower-protein, low-dairy group lost
about a pound and half of muscle whereas the lower-protein, medium dairy group
lost almost no muscle. In marked contrast, the higher-protein, high-dairy group
actually gained a pound and half of muscle, representing a three-pound
difference between the low- and high-dairy groups ... On top of the muscle mass
differences, the higher-protein, high-dairy group lost twice as much belly fat
than the lower-protein, low-dairy group ... These women also got fitter and
stronger" - See my yogurt recipe on my yogurt
page.
-
Eating
protein throughout the day preserves muscle and physical function in dieting
postmenopausal women, study suggests - Science Daily, 8/10/11 -
"higher protein intake during weight loss can offset
negative effects on muscle mass by maintaining more muscle relative to the
amount of weight lost. Women who ate more protein lost 3.9 percent more weight
and had a relative gain of 5.8 percent more thigh muscle volume than woman who
did not ... 31 healthy, postmenopausal obese women were divided into two groups.
Each group followed a 1,400-calorie weight-loss diet based on USDA's My Pyramid,
but one group received a powdered whey protein supplement in the morning and
again in the afternoon or evening; the other received a placebo that contained
carbohydrates ... We hypothesize that more vigorous exercise -- in particular,
resistance training -- would preserve even more muscle" - See
whey protein at Amazon.com
or try the yogurt recipe at the top of my yogurt page.
-
Masticating 40 times per bite is key to weight loss, study says - The Daily,
7/31/11 - "People who chewed 40 times ended up consuming
12 percent fewer calories, according to researchers at Harbin Medical University
in China ... If the average person cut his calorie intake by 12 percent, he
would lose nearly 25 pounds in one year ... Chewing more was associated with
lower blood levels of ghrelin, a hormone that stimulates appetite, as well as
higher levels of CCK, a hormone believed to reduce appetite"
-
Is lost lean
mass from intentional weight loss recovered during weight regain in
postmenopausal women? - Am J Clin Nutr. 2011 Jul 27 -
"All body mass and composition variables were lower
immediately after weight loss than at baseline (all P < 0.05). More fat than
lean mass was lost with weight loss, which resulted in body-composition changes
favoring a lower percentage of body fat and a higher lean-to-fat mass ratio (P <
0.001). Considerable interindividual variability in weight regain was noted (CV
= 1.07). In women who regained ≥2 kg body weight, a decreasing trend in the
lean-to-fat mass ratio was observed, which indicated greater fat mass accretion
than lean mass accretion (P < 0.001). Specifically, for every 1 kg fat lost
during the weight-loss intervention, 0.26 kg lean tissue was lost; for every 1
kg fat regained over the following year, only 0.12 kg lean tissue was regained
... Although not all postmenopausal women who intentionally lose weight will
regain it within 1 y, the data suggest that fat mass is regained to a greater
degree than is lean mass in those who do experience some weight regain"
-
Increased
Consumption of Dairy Foods and Protein during Diet- and Exercise-Induced Weight
Loss Promotes Fat Mass Loss and Lean Mass Gain in Overweight and Obese
Premenopausal Women - J Nutr. 2011 Jul 20 - "Weight
loss can have substantial health benefits for overweight or obese persons;
however, the ratio of fat:lean tissue loss may be more important. We aimed to
determine how daily exercise (resistance and/or aerobic) and a hypoenergetic
diet varying in protein and calcium content from dairy foods would affect the
composition of weight lost in otherwise healthy, premenopausal, overweight, and
obese women. Ninety participants were randomized to 3 groups (n = 30/group):
high protein, high dairy (HPHD), adequate protein, medium dairy (APMD), and
adequate protein, low dairy (APLD) differing in the quantity of total dietary
protein and dairy food-source protein consumed: 30 and 15%, 15 and 7.5%, or 15
and <2% of energy, respectively. Body composition was measured by DXA at 0, 8,
and 16 wk and MRI (n = 39) to assess visceral adipose tissue (VAT) volume at 0
and 16 wk. All groups lost body weight (P < 0.05) and fat (P < 0.01); however,
fat loss during wk 8-16 was greater in the HPHD group than in the APMD and APLD
groups (P < 0.05). The HPHD group gained lean tissue with a greater increase
during 8-16 wk than the APMD group, which maintained lean mass and the APLD
group, which lost lean mass (P < 0.05). The HPHD group also lost more VAT as
assessed by MRI (P < 0.05) and trunk fat as assessed by DXA (P < 0.005) than the
APLD group. The reduction in VAT in all groups was correlated with intakes of
calcium (r = 0.40; P < 0.05) and protein (r = 0.32; P < 0.05). Therefore, diet-
and exercise-induced weight loss with higher protein and increased dairy product
intakes promotes more favorable body composition changes in women characterized
by greater total and visceral fat loss and lean mass gain" - Note: See
the yogurt recipe on my yogurt page.
-
Whey Protein May Be Helpful for Weight Loss - WebMD, 7/15/11 -
"Researchers at the U.S. Department of Agriculture's
Human Nutrition Research Center randomly assigned 90 overweight and obese
middle-aged adults to one of three groups. The first group was asked to add
protein drinks made with whey to their normal diets, the second group drank
protein drinks made with soy protein, and the third group drank carbohydrate
drinks ... the drinks, which were drunk twice daily, at breakfast and dinner,
had the same number of calories: 200. They also all had had 52 grams per packet,
for a daily total of 104 grams of added protein or carbs ... After six months,
people drinking the carbohydrate shakes had gained a little bit of weight, about
2 pounds, which appeared to be mainly added fat ... People drinking the soy
shakes had stayed about the same weight as where they started ... But people
drinking the whey protein had lost a little bit of weight and body fat, about 2
pounds. Additionally, while the other groups saw little change in the size of
their waists, the whey protein group lost about an inch around the middle ... a
couple of things may help to explain the weight and fat loss seen with whey
protein ... People in the whey protein group had significantly lower blood
levels of the hormone ghrelin than people eating the soy protein or carbohydrate
... And though researchers really can't explain why this happened or what it
means, they found that people drinking the whey protein had cut back on their
carbohydrate intake by the end of the study, even though they weren't eating
fewer total calories and didn't know what kind of supplement they were getting
... researchers advise picking a whey product that is also low in calories and
fat" - See
whey protein at Amazon.com.
-
Waistlines in people, glucose levels in mice hint at sweeteners' effects:
Related studies point to the illusion of the artificial - Science Daily,
6/27/11 - "In the constant battle to lose inches or at
least stay the same, we reach for the diet soda. Two studies presented June 25
and 27 at the American Diabetes Association's Scientific Sessions in San Diego
suggest this might be self-defeating behavior ... diet soft drink consumption is
associated with increased waist circumference in humans, and a second study that
found aspartame raised fasting glucose (blood sugar) in diabetes-prone mice ...
The average follow-up time was 9.5 years ... Diet soft drink users, as a group,
experienced 70 percent greater increases in waist circumference compared with
non-users. Frequent users, who said they consumed two or more diet sodas a day,
experienced waist circumference increases that were 500 percent greater than
those of non-users ... In the related project ... One group of the mice ate chow
to which both aspartame and corn oil were added; the other group ate chow with
the corn oil added but not the aspartame. After three months on this high-fat
diet, the mice in the aspartame group showed elevated fasting glucose levels but
equal or diminished insulin levels, consistent with early declines in pancreatic
beta-cell function"
-
Fat
substitutes linked to weight gain: Rats on high-fat diet gained more weight
after eating low-calorie potato chips made with fat substitutes - Science
Daily, 6/20/11 - "Half of the rats in each group also
were fed Pringles potato chips that are high in fat and calories. The remaining
rats in each group were fed high-calorie Pringles chips on some days and
low-calorie Pringles Light chips on other days. The Pringles Light chips are
made with olestra, a synthetic fat substitute that has zero calories and passes
through the body undigested ... For rats on the high-fat diet, the group that
ate both types of potato chips consumed more food, gained more weight and
developed more fatty tissue than the rats that ate only the high-calorie chips.
The fat rats also didn't lose the extra weight even after the potato chips were
removed from their diet. "Based on this data, a diet that is low in fat and
calories might be a better strategy for weight loss than using fat substitutes,"
... Food with a sweet or fatty taste usually indicates a large number of
calories, and the taste triggers various responses by the body, including
salivation, hormonal secretions and metabolic reactions. Fat substitutes can
interfere with that relationship when the body expects to receive a large burst
of calories but is fooled by a fat substitute ... Swithers and Davidson have
reported similar findings in previous rat studies that showed saccharin and
other artificial sweeteners also can promote weight gain and increased body fat"
-
Cut down
on 'carbs' to reduce body fat, study authors say - Science Daily, 6/5/11 -
"Subjects received either a standard lower-fat diet or a
diet with a modest reduction in carbohydrates, or "carbs," but slightly higher
in fat than the standard diet. The moderately carb-restricted diet contained
foods that had a relatively low glycemic index, a measure of the extent to which
the food raises blood glucose levels. This diet consisted of 43 percent calories
from carbohydrates and 39 percent calories from fat, whereas the standard diet
contained 55 percent of calories from carbohydrates and 27 percent from fat.
Protein made up the other 18 percent of each diet ... After the weight
maintenance phase, subjects who consumed the moderately carb-restricted diet had
11 percent less deep abdominal fat than those who ate the standard diet.
However, when the researchers analyzed results by race, they found it was
exclusive to whites. Whites have more deep abdominal fat than Blacks even when
matched for body weight or percent body fat, and may benefit from loss of this
metabolically harmful depot"
-
Healthy
gut flora could prevent obesity, rat study suggests - Science Daily, 5/25/11
- "Poor gut flora is believed to trigger obesity. In the
same way, healthy gut flora could reduce the risk. This has shown to be the case
in tests on rats. Daily intake of a lactic acid bacteria, which has been given
the name Lactobacillus plantarum HEAL19, appears to be able to prevent obesity
and reduce the body's low-level inflammation ... Rats who were given this
specific lactic acid bacterium from their time in the uterus up to adult age put
on significantly less weight than other rats. Both groups ate the same amount of
high-energy food ... A third group of rats were given the inflammation-causing
Escherichia coli bacteria in their drinking water, in addition to the same
high-energy food as the other rats. The E. coli supplement led to changes in gut
flora and increased body fat ... A healthy gut flora at an early stage appears
to play a part in children's wellbeing later in life"
-
Eat a
protein-rich breakfast to reduce food cravings, prevent overeating later,
researcher finds - Science Daily, 5/19/11 - "eating
a healthy breakfast, especially one high in protein, increases satiety and
reduces hunger throughout the day. In addition, using functional magnetic
resonance imaging (fMRI) the researchers found that eating a protein-rich
breakfast reduces the brain signals controlling food motivation and
reward-driven eating behavior ... These findings suggest that a protein-rich
breakfast might be an effective strategy to improve appetite control and prevent
overeating in young people"
-
Citrus extracts show energy burning potential, without side effects: Study -
Nutra USA, 5/17/11 - "consumption of 100 mg hesperidin,
50 mg p-synephrine (from bitter orange), and 600 mg naringin increased the
resting metabolic rate by about 18 percent ... If one assumes that the product
was taken twice a day for one year, the theoretical increase in calorie
consumption would amount to over 31 pounds ... None of the treatment groups
exhibited changes in heart rate or blood pressure relative to the control group,
nor there were no differences in self-reported ratings of 10 symptoms between
the treatment groups and the control group ... the thermogenic effect of
p-synephrine may be increased by naringin and hesperidin via an enhancement in
the production of the expression of adiponectin, a hormone released from fat
cells, which plays an important role in the regulation of insulin sensitivity
and energy" - [Abstract]
-
Breakfast
frequency inversely associated with BMI and body fatness in Hong Kong Chinese
children aged 9-18 years - "The prevalence of
obesity among breakfast skippers, semi-skippers and non-skippers was,
respectively, 9.8, 10.6 and 3.8 % (P < 0.001) for primary school students and
3.9, 3.1 and 2.4 % (P < 0.001) for secondary school students. The 12 % of Hong
Kong children aged 9-18 years who skipped breakfast had higher BMI, BMI z-scores
and percentage of body fat (PBF) than their counterparts. The dose effects of
breakfast frequency (unstandardised regression coefficient, P < 0.001) on BMI
and PBF were, respectively, - 0.125 kg/m2 and - 0.219 % for boys and - 0.165
kg/m2 and - 0.353 % for girls, adjusting for physical activity per additional
breakfast meal per week. Further study is recommended to elucidate whether
regular breakfast consumption may have a role in the prevention of childhood
obesity" - Note: I don't know what the problem is with the "." in the
actual abstract instead of the "." but I fixed it so it wouldn't be so
confusing.
-
Green tea shows body weight and fat benefits: Rat study - Nutra USA, 3/30/11
- "Rats consuming green tea along with a high fat diet
gained less body weight and accumulated less fat than animals not supplemented
with tea, says a new study ... Consuming the equivalent of five to eight cups of
green tea a day was associated with a 5.6 percent decrease in body weight gain,
and a 17.8 percent decrease in fat accumulation over eight weeks" - [Abstract]
- See
green tea extract at Amazon.com.
-
Green
tea aqueous extract reduces visceral fat and decreases protein availability in
rats fed with a high-fat diet - Nutr Res. 2011 Feb;31(2):157-64 -
"Green tea is associated with beneficial health effects
mainly because of its body fat-reducing and hypocholesterolemic activities, but
an effective dose without pronounced influence on protein availability is
unknown. The objective of this study was to examine the hypothesis that green
tea aqueous extract (GTAE) depending on dose improves cardiovascular risk
indicators such as body weight, visceral fat content, and atherogenic index of
plasma and does not have unfavorable effect on protein availability in rats fed
with a high-fat diet. The rats fed with a high-fat diet enriched with 1.1 and
2.0% GTAE for 8 weeks had significantly (P < .05) lower atherogenic index (in
both groups, about 14.3%). Only administration of 2.0% GTAE significantly (P <
.05) decreased body weight gain (5.6%) and prevented visceral fat accumulation
(17.8%) in rats. However, considerably (P < .05), reduction in the digestion of
protein (but not fat) was observed in both GTAE groups (1.1% GTAE: 82.6% +/-
1.8%; 2.0% GTAE: 84.3% +/- 0.8%) when compared to the control (93.3% +/- 1.5%).
It was concluded that GTAE may have preventive effects on the accumulation of
visceral fat but only in higher doses. Although both doses improved
cardiovascular risk indicators, they, in addition, significantly inhibited
protein digestion"
- See
green tea extract at Amazon.com.
-
Resveratrol may be useful tool for reducing body fat - Science Daily, 3/4/11
- "This thesis shows, on the one hand, the results
obtained after treatment with CLA in hamsters subjected to energy restriction
and, on the other, the effect of resveratrol on accumulated fat and lipolytic
activity in cell cultures of adipocytes of murinae and humans. The results
obtained show that CLA does not foment weight or body fat loss, induced by an
energy restriction diet. Neither does it induce greater lipolysis, nor
improvement in serum parameters, in glucose homeostasis or insulin function to
any greater extent than with the slimming diet itself. On the contrary,
resveratrol reduces the accumulation of triglycerides, in part by activation of
lipolysis, in both the adipocytes of mice and of humans ... For all these
reasons, it can be concluded that, while CLA may not be a molecule useful in
treating obesity, when resveratrol is included in hypocaloric diet, it could
well be a useful tool for reducing body fat" - See
resveratrol products at Amazon.com
and
conjugated linoleic acid at Amazon.com.
-
A
protein-rich beverage consumed as a breakfast meal leads to weaker appetitive
and dietary responses v. a protein-rich solid breakfast meal in adolescents
- Br J Nutr. 2011 Feb 15:1-5 - "A total of fifteen
adolescents (eight girls and seven boys; age 14 (sem 1) years, BMI percentile 79
(sem 4) %) randomly completed two testing days that included protein-rich (PR)
breakfast meals (38 % of energy as protein, 48 (sem 2) g/meal) provided as a
solid (S) or beverage (B). Breakfast was 24 % of estimated daily energy needs
(2146 (sem 96) kJ/meal). Perceived appetite and satiety responses were collected
over 5 h followed by an ad libitum lunch buffet. The PR-S meal led to greater
reductions in 4 h postprandial appetite ( - 6221 (sem 1171) mm × 240 min) v. the
PR-B meal ( - 3570 (sem 957) mm × 240 min; P < 0.05). When examining the data
according to hourly responses, the PR-S meal led to greater reductions in
appetite during postprandial hours 2, 3 and 4 v. the PR-B meal (all comparisons,
P < 0.05). No differences in postprandial hourly or total (4 h) fullness were
observed following the PR-S v. PR-B meals. The PR-S meal led to approximately
480 kJ less energy consumed at the ad libitum lunch buffet (1418 (sem 222) kJ)
v. the PR-B meal (1900 (sem 326) kJ; P < 0.05). These data indicate that,
although the food form of the PR breakfast meals had little, if any, effect on
satiety, the appetitive responses were diminished and the subsequent food intake
was greater when protein was consumed as a beverage v. a solid meal"
-
Effects of Metformin on Body Weight and Body Composition in Obese
Insulin-Resistant Children: A Randomized Clinical Trial - Diabetes. 2011 Jan
12 -
"1,000 mg metformin (n = 53) or placebo (n = 47) twice
daily for 6 months ...Children prescribed metformin had significantly greater
decreases in BMI (difference -1.09 kg/m(2), CI -1.87 to -0.31, P = 0.006), body
weight (difference -3.38 kg, CI -5.2 to -1.57, P < 0.001), BMI Z score
(difference between metformin and placebo groups -0.07, CI -0.12 to -0.01, P =
0.02), and fat mass (difference -1.40 kg, CI -2.74 to -0.06, P = 0.04). Fasting
plasma glucose (P = 0.007) and homeostasis model assessment (HOMA) insulin
resistance index (P = 0.006) also improved more in metformin-treated children
than in placebo-treated children. Gastrointestinal symptoms were significantly
more prevalent in metformin-treated children, which limited maximal tolerated
dosage in 17%. During the 6-month open-label phase, children treated previously
with placebo decreased their BMI Z score; those treated continuously with
metformin did not significantly change BMI Z score further. CONCLUSIONS
Metformin had modest but favorable effects on body weight, body composition, and
glucose homeostasis in obese insulin-resistant children participating in a
low-intensity weight-reduction program" - Note: 3.38 kg equals 7.4
pounds. See
metformin at IAS.
-
Low
blood levels of vitamin D linked to chubbier kids, faster weight gain -
Science Daily, 11/8/10 - "the kids with the lowest
vitamin D levels at the beginning tended to gain weight faster than the kids
with higher levels ... children with the lowest vitamin D levels had more
drastic increases in central body fat measures ... Vitamin D deficiency was also
linked to slower growth in height among girls but not boys" - See
vitamin D at Amazon.com.
-
Eating
mostly whole grains, few refined grains linked to lower body fat - Science
Daily, 10/20/10 - "People who consume several servings
of whole grains per day while limiting daily intake of refined grains appear to
have less of a type of fat tissue thought to play a key role in triggering
cardiovascular disease and type 2 diabetes ... Visceral Adipose Tissue ... VAT
volume was approximately 10 % lower in adults who reported eating three or more
daily servings of whole grains and who limited their intake of refined grains to
less than one serving per day ... Visceral fat surrounds the intra-abdominal
organs while subcutaneous fat is found just beneath the skin ... visceral fat is
more closely tied to the development of metabolic syndrome ... participants who
consumed, on average, three daily servings of whole grains but continued to eat
many refined grains did not demonstrate lower VAT volume"
-
Too much
light at night at night may lead to obesity, study finds - Science Daily,
10/11/10 - "mice exposed to a relatively dim light at
night over eight weeks had a body mass gain that was about 50 percent more than
other mice that lived in a standard light-dark cycle ... Something about light
at night was making the mice in our study want to eat at the wrong times to
properly metabolize their food ... So how does light at night lead to changes in
metabolism? The researchers believe the light could disrupt levels of the
hormone melatonin, which is involved in metabolism. In addition, it may disrupt
the expression of clock genes, which help control when animals feed and when
they are active"
-
Sleep
loss limits fat loss - Science Daily, 10/4/10 -
"When dieters got adequate sleep, however, more than half of the weight they
lost was fat. When they cut back on their sleep, only one-fourth of their weight
loss came from fat"
-
Drink
water to curb weight gain? Clinical trial confirms effectiveness of simple
appetite control method - Science Daily, 8/23/10 -
"We found in earlier studies that middle aged and older people who drank two
cups of water right before eating a meal ate between 75 and 90 fewer calories
during that meal. In this recent study, we found that over the course of 12
weeks, dieters who drank water before meals, three times per day, lost about 5
pounds more than dieters who did not increase their water intake"
-
Green Tea
Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese
Subjects with Metabolic Syndrome - J Am Coll Nutr. 2010 Feb;29(1):31-40 -
"Green tea beverage consumption (4 cups/d) or
extract supplementation (2 capsules/d) for 8 weeks significantly decreased body
weight and BMI. Green tea beverage further lowered lipid peroxidation versus
age- and gender-matched controls, suggesting the role of green tea flavonoids in
improving features of metabolic syndrome in obese patients" - See
green tea extract at Amazon.com.
-
Lemurs lose weight with 'life-extending' supplement resveratrol -
Science Daily, 6/22/10 - "The anti-obesity
properties of resveratrol have been demonstrated for the first time in a
primate ... lemurs eating a diet supplemented with the compound decreased
their energy intake by 13% and increased their resting metabolic rate by 29%
... a four-week resveratrol supplementation was associated with a decrease
in food intake and a reduction in seasonal body-mass gain. The response to
resveratrol supplementation also involved significant changes in the
animals' body temperatures" - [Nutra
USA] - See
resveratrol products at Amazon.com.
-
Probiotics may help fat and weight loss: Study - Nutra USA, 6/11/10 -
"Twelve weeks of consuming a fermented milk product
containing the Lactobacillus strain was associated with a 4.6 per cent
reduction in abdominal fat, and a 3.3 per cent reduction in subcutaneous
fat" - [Abstract]
- See
Yogourmet Electric Yogurt Maker - I've had a lot of yogurt makers
over the years but this is the best one I've found. I mix two cups of
Nestle Nido Instant Dry Whole Milk (available at Amazon) with two
cups of dry skim milk in a blender. Lately I've been making it with
Activa. I believe it's only sold flavored but I've been using the
strawberry flavored Activa. I put the milk powders in a blender then
fill it with water and blend. Then add one container of the Activa and
blend fast one more time (not to kill the culture). Then pour it into
the jar and fill the jar to the top with additional water and leave it
in the yoghurt maker for 13 hours. I mix the finished product with
Smucker's Strawberry Orchard's Finest. If your worried about the
BPA's from the plastic container, see
Widemouth Clear Half Gallon Glass Jar (64oz) w/ White Metal Lid at
specialtybottles.com.
- Activia by Dannon
- "Specialists at Dannon® selected Bifidus
Regularis™ for Activia® because it survives passage through the
digestive tract, arriving in the colon as a living culture. Once there,
it plays a beneficial role in your intestinal ecosystem"
-
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055)
in adults with obese tendencies in a randomized controlled trial - Eur J
Clin Nutr. 2010 Jun;64(6):636-43 - "fermented milk (FM)
... In the active FM group, abdominal visceral and subcutaneous fat areas
significantly (P<0.01) decreased from baseline by an average of 4.6% (mean
(confidence interval): -5.8 (-10.0, -1.7) cm(2)) and 3.3% (-7.4 (-11.6, -3.1)
cm(2)), respectively. Body weight and other measures also decreased
significantly (P<0.001) as follows: body weight, 1.4% (-1.1 (-1.5, -0.7) kg);
BMI, 1.5% (-0.4 (-0.5, -0.2) kg/m(2)); waist, 1.8% (-1.7 (-2.1, -1.4) cm); hip,
1.5% (-1.5 (-1.8, -1.1) cm). In the control group, by contrast, none of these
parameters decreased significantly. High-molecular weight adiponectin in serum
increased significantly (P<0.01) in the active and control groups by 12.7% (0.17
(0.07, 0.26) microg/ml) and 13.6% (0.23 (0.07, 0.38) microg/ml), respectively.
CONCLUSION: The probiotic LG2055 showed lowering effects on abdominal adiposity,
body weight and other measures, suggesting its beneficial influence on metabolic
disorders"
-
To burn
more fat, don’t eat before workout - MSNBC, 6/3/10 -
"cyclists who trained without eating burned
significantly more fat than their counterparts who ate ... When you exercise
(after fasting), your adrenaline is high and your insulin is low ... That
ratio is favorable for your muscles to oxidize (break down) more fatty
acids"
-
New
evidence that chili pepper ingredient fights fat - Science Daily, 6/2/10
- "The capsaicin-treated rats lost 8 percent of
their body weight and showed changes in levels of at least 20 key proteins
found in fat. The altered proteins work to break down fats. "These changes
provide valuable new molecular insights into the mechanism of the
antiobesity effects of capsaicin,"" - See
capsaicin supplements at Amazon.com.
-
Milk: Two glasses a day tones muscles, keeps the fat away in women, study
shows - Science Daily, 5/26/10 - "Women who
drink two large glasses of milk a day after their weight-lifting routine
gained more muscle and lost more fat compared to women who drank sugar-based
energy drinks ... The women who drank milk gained barely any weight because
what they gained in lean muscle they balanced out with a loss in fat"
-
Resveratrol regulates human adipocyte number and function in a
Sirt1-dependent manner - Am J Clin Nutr. 2010 May 12 -
"Taken together, our data suggest that resveratrol
influences adipose tissue mass and function in a way that may positively
interfere with the development of obesity-related comorbidities. Thus, our
findings open up the new perspective that resveratrol-induced intracellular
pathways could be a target for prevention or treatment of obesity-associated
endocrine and metabolic adverse effects" - See
resveratrol products at Amazon.com.
-
Green tea extract effective for weight loss at low doses - Nutra USA,
4/9/10 - "during two hours after a meal, the
low-dose EGCG supplementation was associated with a 33 per cent increase in
fat oxidation. The high-dose EGCG supplementation produced a non-significant
20 per cent increase, compared to placebo. Caffeine alone was associated
with a 34.5 per cent increase, compared with placebo, while the combined
EGCG/ /caffeine supplement boosted fat oxidation by 49 per cent ... during
two hours after a meal, the low-dose EGCG supplementation was associated
with a 33 per cent increase in fat oxidation. The high-dose EGCG
supplementation produced a non-significant 20 per cent increase, compared to
placebo. Caffeine alone was associated with a 34.5 per cent increase,
compared with placebo, while the combined EGCG/ /caffeine supplement boosted
fat oxidation by 49 per cent. “There is no synergism of low EGCG and 200 mg
caffeine,” " - [Abstract]
- See
green tea extract at Amazon.com.
-
Weight-loss supplement has potential to burn fair amount of calories -
Science Daily, 2/2/10 - "the nutritional supplement
called the tri-pepper blend, which contains black pepper, caffeine and a
concentrated form of capsaicin -- the ingredient that makes red peppers hot.
The OU study showed energy expenditures of three to six percent, results
which are statistically significant enough to validate product weight-loss
claims"
-
Pomegranate oil-seaweed mix may improve liver health and waist size -
Nutra USA, 1/25/10 - "Results showed that body
weight was significantly reduced by an average of 5.5 kg in people in the
NAFLD group and 4.9 kg in the normal liver function group. Women in the
placebo group lost an average of 1.4 kilos. In addition, women with NAFLD
experienced improvements in waist circumference, body and liver fat content,
liver enzymes, and serum triglycerides" - [Abstract]
- 5.5 kg is 12.1 pounds - See
FucoThin at Amazon.com
-
The
effects of Xanthigen in the weight management of obese premenopausal women with
non-alcoholic fatty liver disease and normal liver fat - Diabetes Obes
Metab. 2010 Jan;12(1):72-81 - "Xanthigen-600/2.4 mg (300
mg PSO + 300 mg brown seaweed extract containing 2.4 mg fucoxanthin) resulted in
statistically significant reduction of body weight (5.5 +/- 1.4 kg NAFLD group
and 4.9 +/- 1.2 kg NLF group, p < 0.05), waist circumference (NAFLD group only),
body (3.5 +/- 1.9 kg NAFLD group, p < 0.001; 3.6 +/- 0.7 kg NLF group, p < 0.05)
and liver fat content, liver enzymes (NAFLD group only), serum triglycerides and
C-reactive protein. Weight loss and reduction in body and liver fat content
occurred earlier in patients with NLF than in patients with NAFLD. Fucoxanthin
(> 2.4 mg) and Xanthigen-400/1.6 mg (200 mg PSO + 200 mg brown seaweed extract
containing 1.6 mg fucoxanthin) significantly increased REE in NAFLD subjects
compared to placebo. CONCLUSIONS: Xanthigen promoted weight loss, reduced body
and liver fat content, and improved liver function tests in obese non-diabetic
women. Xanthigen and Fucoxanthin also increased REE. This product may be
considered a promising food supplement in the management of obesity" -
See
FucoThin at Amazon.com
-
Dietary Fiber May Help Prevent Body Weight, Waist Circumference Gain -
Medscape, 1/6/10 - "There was an inverse association of
total fiber intake with subsequent change in weight and in waist circumference.
For each 10-g/day increase in total fiber intake, the pooled estimate was –39
g/year (95% confidence interval [CI], –71 to –7 g/year) for weight change and
–0.08 cm/year (95% CI, –0.11 to –0.05 cm/year) for waist circumference change
... For each 10-g/day increase in fiber intake from cereals, there was a weight
change of –77 g/year (95% CI, –127 to –26 g/year) and change in waist
circumference of –0.10 cm/year (95% CI, –0.18 to –0.02 cm/year). Fruit and
vegetable fiber was not associated with weight change. However, the association
of fruit and vegetable fiber intake with change in waist circumference was
similar to that seen for intake of total dietary fiber and cereal fiber"
-
Another
Cause of Obesity: The Bacteria in Your Gut? - Time Magazine, 11/12/09 -
"When one group of mice was fed a typical Western diet,
high in fat and sugars, they tended to gain weight and grow more Firmicutes gut
bacteria and fewer Bacteroidetes. In mice given a low-fat, plant-based chow, the
distribution of the two groups of bugs flipped and the animals remained lean.
It's not clear whether the balance of gut bugs causes weight gain or is a result
of it, but the findings suggest that a "gut profile" could potentially serve as
a diagnostic tool for identifying who might have a propensity for obesity. If,
for instance, your gut environment contains a preponderance of Firmicutes, then
your body may be predisposed to digest calories in a way that leads to greater
fat storage. In fact, in Gordon's earlier work with identical twins of different
weights, he found that the obese twin tended to have more Firmicutes colonies
than the leaner sibling ...factors like gut microbes, which scientists
traditionally would not think of exerting influence on genes, may have a
surprisingly powerful effect, changing how a body's genes would normally control
the way it digest food and breaks it down into energy"
-
Gut microflora and obesity: Study highlights potential for pre-, probiotics
- Nutra USA, 11/12/09 - "One approach could involve
searching for nutritional interventions to modify specific gut microbial
species. Dietary components (prebiotics) might be found that alter growth of
specific microbial species capable of affecting host physiology, and the
Turnbaugh model can be used to pinpoint these elements and decipher the
mechanisms of the host-microbe collaboration"
-
Eat Late, Put on Weight? - WebMD, 9/3/09 - "eating
at the "wrong" time leads to more than twice as much weight gain, even when the
overall calories consumed are the same as those eaten at appropriate time"
-
Low-carb
Diets Linked To Atherosclerosis And Impaired Blood Vessel Growth - Science
Daily, 8/25/09 - "Even as low-carbohydrate/high-protein
diets have proven successful at helping individuals rapidly lose weight, little
is known about the diets' long-term effects on vascular health ... mice placed
on a 12-week low carbohydrate/high-protein diet showed a significant increase in
atherosclerosis, a buildup of plaque in the heart's arteries and a leading cause
of heart attack and stroke ... our research suggests that, at least in animals,
these diets could be having adverse cardiovascular effects that are not
reflected in simple serum markers"
-
Why Exercise
Won't Make You Thin - Time Magazine, 8/9/09 - "Many
obesity researchers now believe that very frequent, low-level physical activity
— the kind humans did for tens of thousands of years before the leaf blower was
invented ��� may actually work better for us than the occasional bouts of exercise
you get as a gym rat ... You cannot sit still all day long and then have 30
minutes of exercise without producing stress on the muscles ... The muscles will
ache, and you may not want to move after. But to burn calories, the muscle
movements don't have to be extreme. It would be better to distribute the
movements throughout the day"
-
Omega-3
fatty acid supplements improve the cardiovascular risk profile of subjects with
metabolic syndrome, including markers of inflammation and auto-immunity -
Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram
of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120
mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any
supplementation over the same period. RESULTS: The study was completed by 47
subjects in the intervention group and 42 subjects in the control group.
Treatment with omega 3 supplements was associated with a significant fall in
body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density
lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05),
triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P <
0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were
observed in the control group. CONCLUSION: It appears that omega 3 improves the
cardiovascular risk profile of subjects with metabolic syndrome, having effects
on weight, systolic blood pressure, lipid profile and markers of inflammation
and autoimmunity" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
High-carb diet could aid slimming: Study - Nutra USA, 7/20/09
-
Two
Dietary Oils, Two Sets Of Benefits For Older Women With Diabetes - Science
Daily, 7/15/09 - "In the study, 16 weeks of
supplementation with safflower oil reduced fat in the trunk area, lowered blood
sugar and increased muscle tissue in the women participants ... Conjugated
linoleic acid supplementation for the same length of time, on the other hand,
reduced total body fat and lowered the women’s body mass index (BMI), a common
health measure of weight relative to height" - See
conjugated linoleic acid at Amazon.com.
-
Citrus-derived Flavonoid Prevents Obesity, Study Suggests - Science Daily,
7/14/09 - "Naringenin corrected the elevations in
triglyceride and cholesterol, prevented the development of insulin resistance
and completely normalized glucose metabolism. The researchers found it worked by
genetically reprogramming the liver to burn up excess fat, rather than store it
... Furthermore, the marked obesity that develops in these mice was completely
prevented by naringenin ... These studies show naringenin, through its
insulin-like properties, corrects many of the metabolic disturbances linked to
insulin resistance and represents a promising therapeutic approach for metabolic
syndrome" - See
naringenin at Amazon.com.
-
New
Evidence That Vinegar May Be Natural Fat-fighter - Science Daily, 6/22/09 -
"Their new study showed that laboratory mice fed a
high-fat diet and given acetic acid developed significantly less body fat (up to
10 percent less) than other mice. Importantly, the new research adds evidence to
the belief that acetic acid fights fat by turning on genes for fatty acid
oxidation enzymes. The genes churn out proteins involved in breaking down fats,
thus suppressing body fat accumulation in the body" - See
apple cider vinegar at Amazon.com
- 4.5 tablets equals about 3 tablespoons by my calculations. I've been
popping 4 of these with meals for years and more and more research keeps backing
me up.
-
Comparison
of dietary conjugated linoleic acid with safflower oil on body composition in
obese postmenopausal women with type 2 diabetes mellitus - Am J Clin Nutr.
2009 Jun 17 - "Supplementation with CLA reduced body
mass index (BMI) (P = 0.0022) and total adipose mass (P = 0.0187) without
altering lean mass. The effect of CLA in lowering BMI was detected during the
last 8 wk of each 16-wk diet period. In contrast, SAF had no effect on BMI or
total adipose mass but reduced trunk adipose mass (P = 0.0422) and increased
lean mass (P = 0.0432). SAF also significantly lowered fasting glucose (P =
0.0343) and increased adiponectin (P = 0.0051). No differences were observed in
dietary energy intake, total fat intake, and fat quality in either diet period
for either intervention. CONCLUSIONS: Supplementation with CLA and SAF exerted
different effects on BMI, total and trunk adipose mass, and lean tissue mass in
obese postmenopausal women with type 2 diabetes" - See
conjugated linoleic acid at Amazon.com.
-
Could vinegar be natural fat fighter? - Nutra USA, 6/18/09 -
"fed mice a high-fat diet, with 50 per cent of energy
coming from fat, and treated the animals with 1.5 per cent vinegar (high-dose
group), 0.3 per cent vinegar (low-dose group), or water (control group) ... the
researchers noted that that both vinegar groups produced reductions in fat mass
of about 10 per cent, with no apparent dose-dependent effect, compared to the
control mice ... The results of this study suggest that acetic acid suppresses
body fat accumulation by increasing fatty oxidation and thermogenesis in the
liver through PPAR-alpha" - [Abstract]
- See vinegar supplements at Amazon.com.
-
Acetic Acid
Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in
Liver To Suppress Body Fat Accumulation - J Agric Food Chem. 2009 May 26
- "acetic acid (AcOH) ... AcOH suppresses
accumulation of body fat and liver lipids by upregulation of genes for
PPARalpha and fatty-acid-oxidation-related proteins by alpha2 AMPK mediation
in the liver" - See apple cider vinegar at Amazon.com.
-
Skip
Breakfast, Get Fat - WebMD, 6/15/09 - "Forgoing the
first meal of the day actually tricks your brain into thinking you want
higher-calorie foods -- foods that can make you fat, or at least increase your
risk for weight gain"
-
Sleep
Restriction Results In Weight Gain Despite Decreases In Appetite And Consumption
- Science Daily, 6/8/09 - "in the presence of free
access to food, sleep restricted subjects reported decrease in appetite, food
cravings and food consumption; however, they gained weight over the course of
the study. Thus, the finding suggests that energy intake exceeded energy
expenditure during the sleep restriction ... Results indicate that people whose
sleep was restricted experienced an average weight gain of 1.31 kilograms over
the 11 days of the study"
-
Compound
In Turmeric Spice May Stall Spread Of Fat Tissue - Science Daily, 5/22/09 -
"supplementing the animals’ high-fat diet with curcumin
reduced body-weight gain and total body fat, even though food-intake was not
affected, when compared to the nonsupplemented high-fat-diet group ... The
curcumin-treated group also had less blood vessel growth in fat tissue. Blood
glucose, triglyceride, fatty acid, cholesterol and liver fat levels also were
lower" - See
curcumin products at Amazon.com.
-
Plasma n-3
polyunsaturated fatty acids are negatively associated with obesity - Br J
Nutr. 2009 May 19:1-5 - "Plasma fatty acid composition
was determined by GC. BMI, waist circumference and hip circumference were
inversely correlated with n-3 PUFA, EPA and DHA (P < 0.05 for all) in the obese
group. Obese individuals had significantly lower plasma concentrations of total
n-3 PUFA, compared with healthy-weight individuals (4.53 (sd 1.11) v. 5.25 (sd
1.43) %)"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Turmeric
Extract Suppresses Fat Tissue Growth In Rodent Models - Science Daily,
5/18/09 - "Curcumin, the major polyphenol found in
turmeric, appears to reduce weight gain in mice and suppress the growth of fat
tissue in mice and cell models" - See
curcumin products at Amazon.com.
-
Lose Weight With a Good Night's Sleep? - WebMD, 5/16/09 -
"The average BMI for short sleepers was 28.3. That
compares to an average BMI of 24.5 for long sleepers. The BMI range for normal
weight is considered to be 18.5-24.9 and for overweight 25.0-29.9. BMI is
calculated from a person's weight and height and is an indicator of body fat"
-
Whole-Grain, Low-Calorie Diet Reduced Body Fat Compared With Refined-Wheat
Low-Calorie Diet - Doctor's Guide, 5/14/09 -
"Patients consuming whole-grain foods had a significantly larger drop in body
fat percentage (assessed by dual-energy x-ray absorptiometry scanning) compared
with patients who had eaten refined foods (-6.8% vs -4.8%; P = .03) ... Total
cholesterol and LDL cholesterol levels rose by 5% in the refined-wheat group but
remained unchanged in the wholemeal-wheat group"
-
White
Tea: Solution To Obesity Epidemic? - Science Daily, 5/7/09 -
"After treating lab-cultured human pre-adipocytes with
the tea extract, the authors found that fat incorporation during the genesis of
new adipocytes was reduced ... The extract solution induced a decrease in the
expression of genes associated with the growth of new fat cells, while also
prompting existing adipocytes to break down the fat they contain ... It is less
processed than the other teas and contains more of the ingredients thought to be
active on human cells, such as methylxanthines (like caffeine) and
epigallocatechin-3-gallate (EGCG) – which the authors believe to be responsible
for many of the anti-adipogenic effects demonstrated in their study" -
See
green tea extract at Amazon.com.
-
Study In
Pregnant Women Suggests Probiotics May Help Ward Off Obesity - Science
Daily, 5/7/09 - "One year after giving birth, women were
less likely to have the most dangerous kind of obesity if they had been given
probiotics from the first trimester of pregnancy, found new research that
suggests manipulating the balance of bacteria in the gut may help fight obesity
... Central obesity, where overall obesity is combined with a particularly fat
belly, is considered especially unhealthy ... We found it in 25% of the women
who had received the probiotics along with dietary counselling, compared with
43% in the women who received diet advice alone" - See
probiotics at Amazon.com.
-
Curcumin may cut body fat and weight gain: Mouse study - Nutra USA, 4/27/09
- "The curcumin suppression of angiogenesis in adipose
tissue together with its effect on lipid metabolism in adipocytes may contribute
to lower body fat and body weight gain ... Curcumin was also associated with
significantly lower cholesterol levels and a reduction in the expression of
peroxisome proliferators-activated receptor gamma (PPAR-gamma), a protein that
plays a role in metabolic functions" - [Abstract]
- See
curcumin products at Amazon.com.
-
Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity
in C57/BL mice - J Nutr. 2009 May;139(5):919-25 -
"Supplementing the high-fat diet of mice with curcumin did not affect food
intake but reduced body weight gain, adiposity, and microvessel density in
adipose tissue, which coincided with reduced expression of vascular endothelial
growth factor (VEGF) and its receptor VEGFR-2. Curcumin increased
5'AMP-activated protein kinase phosphorylation, reduced glycerol-3-phosphate
acyl transferase-1, and increased carnitine palmitoyltransferase-1 expression,
which led to increased oxidation and decreased fatty acid esterification ... Our
findings suggest that dietary curcumin may have a potential benefit in
preventing obesity" - See
curcumin products at Amazon.com.
-
Green Tea
(-)-Epigallocatechin-3-Gallate Reduces Body Weight with Regulation of Multiple
Genes Expression in Adipose Tissue of Diet-Induced Obese Mice - Ann Nutr
Metab. 2009 Apr 22;54(2):151-157 - "Experimental diets
supplemented with EGCG resulted in reduction of body weight and mass of various
adipose tissues in a dose-dependent manner. EGCG diet also considerably lowered
the levels of plasma triglyceride and liver lipid. In the epididymal white
adipose tissue of EGCG diet-fed mice, the mRNA levels of adipogenic genes such
as peroxisome proliferator-activated receptor-gamma (PPAR-gamma), CCAAT
enhancer-binding protein-alpha (C/EBP-alpha), regulatory element-binding
protein-1c (SREBP-1c), adipocyte fatty acid-binding protein (aP2), lipoprotein
lipase (LPL) and fatty acid synthase (FAS) were significantly decreased.
However, the mRNA levels of carnitine palmitoyl transferase-1 (CPT-1) and
uncoupling protein 2 (UCP2), as well as lipolytic genes such as hormone
sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), were
significantly increased ... These results suggest that green tea EGCG
effectively reduces adipose tissue mass and ameliorates plasma lipid profiles in
high-fat diet-induced obese mice. These effects might be at least partially
mediated via regulation of the expression of multiple genes involved in
adipogenesis, lipolysis, beta-oxidation and thermogenesis in white adipose
tissue" - See
green tea extract at Amazon.com.
-
Low
Glycemic Breakfast May Increase Benefits Of Working Out - Science Daily,
4/15/09 - "Overall, fat oxidation was higher in the LGI
treatment than in the HGI treatment (P < 0.05) during the post-breakfast and
exercise periods. Following lunch, fullness scores were higher in the LGI trial
than in the HGI trial (P < 0.05). The authors concluded that consuming a LGI
breakfast increases fat oxidation during subsequent exercise and improved
satiety during recovery in sedentary females. As such, individuals trying to
shed fat may consider choosing LGI foods eaten prior to when they exercise"
-
Beverage
Consumption A Bigger Factor In Weight, Study Shows - Science Daily, 4/2/09
-
Grape polyphenols may protect against obesity: Study - Nutra USA, 3/18/09 -
"animals fed a high-fat diet but supplemented with the
grape seed extract had adiponectin levels 61 per cent higher than animals only
fed the high fat diet. Adiponectin is a protein hormone linked to various
metabolic processes, and levels are inversely related to body fat levels"
- [Abstract] - See
grape seed extract at Amazon.com.
-
Chardonnay grape seed procyanidin extract supplementation prevents high-fat
diet-induced obesity in hamsters by improving adipokine imbalance and oxidative
stress markers - Mol Nutr Food Res. 2008 Nov 26 -
"GSE prevented in part these effects, reducing insulinemia and leptinemia by
16.5 and 45%, respectively, whereas adiponectin level increased by 61% compared
with obese controls. GSE lowered glycemia and HOMA-IR and strongly prevented
cardiac production of superoxide by 74% and NAD(P)H oxidase expression by 30%.
This is the first time that chronic consumption of grape phenolics is shown to
reduce obesity development and related metabolic pathways including adipokine
secretion and oxidative stress" - See
grape seed extract at Amazon.com.
-
Scientists Discover Why A Low GI Meal Makes You Feel Full - Science Daily,
3/18/09 - "Eating a meal with a low GI (glycaemic index)
increases gut hormone production which leads to suppression of appetite and the
feeling of fullness"
-
Not
Enough Vitamin D In The Diet Could Mean Too Much Fat On Adolescents -
Science Daily, 3/16/09 - "A Medical College of Georgia
study of more than 650 teens age 14-19 has found that those who reported higher
vitamin D intakes had lower overall body fat and lower amounts of the fat in the
abdomen, a type of fat known as visceral fat, which has been associated with
health risks such as heart disease, stroke, diabetes and hypertension" -
See
vitamin D at Amazon.com.
-
Citicoline
affects appetite and cortico-limbic responses to images of high-calorie foods
- Int J Eat Disord. 2009 Mar 3 -
"Cytidine-5'-diphosphocholine (citicoline) has a variety of cognitive enhancing,
neuroprotective, and neuroregenerative properties. In cocaine-addicted
individuals, citicoline has been shown to increase brain dopamine levels and
reduce cravings ... After 6 weeks, there was no significant change in weight
status, although significant declines in appetite ratings were observed for the
2,000 mg/day group. The higher dose group also showed significant increases in
functional brain responses to food stimuli within the amygdala, insula, and
lateral orbitofrontal cortex. Increased activation in these regions correlated
with declines in appetite ratings ...These preliminary findings suggest a
potential usefulness of citicoline in modulating appetite, but further research
is warranted" - See
citicholine at Amazon.com.
-
Arginine
Discovery Could Help Fight Human Obesity - Science Daily, 2/12/09 -
"arginine, an amino acid, reduces fat mass in
diet-induced obese rats and could help fight human obesity ... dietary arginine
supplementation shifts nutrient partitioning to promote skeletal-muscle gain ...
The findings were published recently in the Journal of Nutrition ... arginine
supplementation for a 12-week period decreased the body fat gains of low-fat and
high-fat fed rats by 65 percent and 63 percent, respectively. The long-term
arginine treatment did not have any adverse effects on either group ... funded
by the American Heart Association" - See
L-arginine products at Amazon.com.
-
Green tea catechins linked to weight loss: Study - Nutra USA, 1/26/09 -
"The subjects were randomly assigned to receive either
500ml per day of a beverage providing 625mg catechins, or a control beverage ...
12-week study period ... people in the catechin group were found to have lost
more body weight compared to the control group ... both total abdominal fat area
(P = 0.013) and abdominal subcutaneous fat area (P = 0.019) had decreased more
in the catechin group" - [Abstract]
- See
green tea extract at Amazon.com.
-
Green
tea catechin consumption enhances exercise-induced abdominal fat loss in
overweight and obese adults - J Nutr. 2009 Feb;139(2):264-70 -
"for 12 wk ... There was a trend (P = 0.079) toward
greater loss of body weight in the catechin group compared with the control
group ... Percentage changes in fat mass did not differ between the catechin
[5.2 (-7.0, -3.4)] and control groups [-3.5 (-5.4, 1.6)] (P = 0.208). However,
percentage changes in total abdominal fat area [-7.7 (-11.7, -3.8) vs. -0.3
(-4.4, 3.9); P = 0.013], subcutaneous abdominal fat area [-6.2 (-10.2, -2.2) vs.
0.8 (-3.3, 4.9); P = 0.019], and fasting serum triglycerides (TG) [-11.2 (-18.8,
-3.6) vs. 1.9 (-5.9, 9.7); P = 0.023] were greater in the catechin group. These
findings suggest that green tea catechin consumption enhances exercise-induced
changes in abdominal fat and serum TG" - See
green tea extract at Amazon.com.
-
Mediterranean Diet Reduces Long-term Risk Of Subsequent Weight Gain And Obesity
Among Adults - Science Daily, 1/22/09 - "increased
fruit and vegetable intake was associated with significantly lower risk of a
medium WG (3,41 kg) over 10 years among adults of a Spanish Mediterranean
population. Dietary strategies to increase fruit and vegetable intake to prevent
and control overweight and obesity should be promoted more vigorously"
-
Dietary
L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle
and Brown Fat Masses in Diet-Induced Obese Rats - J Nutr. 2008 Dec 23 -
"l-arginine-HCl ... Despite similar energy intake,
absolute weights of white fat pads increased by 98% in control rats over a 12-wk
period but only by 35% in arginine-supplemented rats. The arginine treatment
reduced the relative weights of white fat pads by 30% and enhanced those of
soleus muscle by 13%, extensor digitorum longus muscle by 11%, and brown fat by
34% compared with control rats ... arginine treatment resulted in lower serum
concentrations of leptin, glucose, triglycerides, urea, glutamine, and
branched-chain amino acids, higher serum concentrations of nitric-oxide
metabolites, and improvement in glucose tolerance. Thus, dietary arginine
supplementation shifts nutrient partitioning to promote muscle over fat gain and
may provide a useful treatment for improving the metabolic profile and reducing
body white fat in diet-induced obese rats" - See
Jarrow Formulas, Arginine 1000,
1000 mg, 100 Easy-Solv Tablets
at iHerb.
-
Treatment of
white coat hypertension with metformin - Int Heart J. 2008 Nov;49(6):671-9 -
"White coat hypertension (WCH) is most likely a disorder
associated with metabolic syndrome ... Twenty-five cases (14.7%) stopped
metformin therapy due to excessive anorexia. At the end of a 6-month period,
there were highly significant differences between the two groups with respect to
the prevalences of resolved WCH, hyperbetalipoproteinemia, hypertriglyceridemia,
dyslipidemia, overweight and obesity, and decreased fasting plasma glucose below
110 mg/dL ... Thus, the management of WCH should not focus solely on the
regulation of blood pressure with antihypertensive medications, but rather on
the prevention of future excess weight and various associated disorders, and
metformin alone is an effective therapeutic option, most likely due to its
powerful inhibitory effect on appetite"
-
Low-carb
Diets Can Affect Dieters' Cognition Skills - Science Daily, 12/11/08 -
"A new study from the psychology department at Tufts
University shows that when dieters eliminate carbohydrates from their meals,
they performed more poorly on memory-based tasks than when they reduce calories,
but maintain carbohydrates. When carbohydrates were reintroduced, cognition
skills returned to normal"
-
Lack Of
Vitamin D Causes Weight Gain And Stunts Growth In Girls - Science Daily,
12/11/08 - "The high prevalence of vitamin D
insufficiency in young people living in a sun-rich area was surprising," says
study lead author, Richard Kremer, co-director of the Musculoskeletal Axis of
the MUHC. "We found young women with vitamin D insufficiency were significantly
heavier, with a higher body mass index and increased abdominal fat, than young
women with normal levels" - See
vitamin D at Amazon.com.
-
Adiponectin Is A Metabolic Link Between Obesity And Bone Mineral Density -
Science Daily, 11/25/08 - "adiponectin, a protein
secreted from adipocytes, is a metabolic link that can explain, in part, the
known positive relationship between obesity and both bone mineral density and
reduced susceptibility to fractures ... In summary, elevated circulating
adiponectin was associated with lower bone mass and weaker bones in growing mice
compared to control animals" - See my
adiponectin page for ways to increase it. - Ben
-
Vitamin D Insufficiency Linked to Increased Body Fat - Medscape, 11/10/08 -
"The study sample consisted of 90 postpubertal women
aged 16 to 22 years and living in California ... Insufficiency of 25(OH)D,
defined as a serum level of 29 ng/mL or less, was present in approximately 59%
of participants, and the remaining 41% had sufficient 25(OH)D levels, defined as
a serum level of 30 ng/mL or more. Serum 25(OH)D levels were strongly negatively
related to CT measures of visceral and subcutaneous fat and to DXA values of
body fat" - See
vitamin D at Amazon.com.
-
Drug 'tricks body to lose weight' - BBC News, 11/5/08 -
"The drug SRT1720 - a chemical cousin of red wine extract resveratrol - targets
the protein SIRT1, which is thought to combat ageing ... The French team from
the University Louis Pasteur became interested in the SIRT1 protein after
earlier studies showing resveratrol countered some effects of a high-calorie
diet via SIRT1" - See
resveratrol products at Amazon.com.
-
Chronic
Green Tea Consumption Decreases Body Mass, Induces Aromatase Expression, and
Changes Proliferation and Apoptosis in Adult Male Rat Adipose Tissue - J
Nutr. 2008 Nov;138(11):2156-2163 - "Green tea (GT) ...
These results suggest new mechanisms for GT on body weight and highlight its
potential benefit to prevent or treat obesity and the metabolic syndrome"
- See
green tea extract at Amazon.com.
-
Fructose
-- Found In High-fructose Corn Syrup, Sugar -- Sets Table For Weight Gain
Without Warning - Science Daily, 10/16/08 - "Eating
too much fructose can induce leptin resistance, a condition that can easily lead
to becoming overweight when combined with a high-fat, high-calorie diet"
-
MSG Use
Is Linked to Obesity - New York Times, 8/25/08 -
"After controlling for body mass index, smoking, physical activity and almost
two dozen measures of daily nutrient intake, they found that the one-third of
people who used the most MSG were almost three times as likely to be overweight
— that is, to have a body mass index over 25 — as those who used none"
-
Fructose May Make You Fatter - WebMD, 7/31/08 -
"Fructose gets made into fat more quickly, and when that process is turned on
there seems to be a signal that goes to the liver that says store all the other
fats you are seeing"
-
Metformin May Enhance Weight Loss in Female Adolescents - Medscape, 7/8/08 -
"a significant decrease in body mass index was seen in
females receiving metformin but not in those taking placebo. Sixty percent of
participants who were metformin-adherent and who decreased food portion sizes
had a decrease in body mass index of more than 5%" - See
metformin at OffshoreRx1.com.
-
'Big Breakfast' Diet Helps Shed Pounds - WebMD, 6/17/08 -
"Eating a 600-calorie breakfast rich in carbohydrates
and protein helps dieters lose more weight long term than eating a modest
breakfast and following a lower-carb eating plan ... In all, members of the
big-breakfast group lost more than 21% of their
body weight; low-carb group members lost 4.5%"
-
Red
Wine's Resveratrol May Help Battle Obesity - Science Daily, 6/16/08 -
"resveratrol inhibited the pre-fat cells from increasing
and prevented them from converting into mature fat cells. Also, resveratrol
hindered fat storage. Most interesting, according to Fischer-Posovszky, was that
resveratrol reduced production of certain cytokines (interleukins 6 and 8),
substances that may be linked to the development of obesity-related disorders,
such as diabetes and clogged coronary arteries. Also, resveratrol stimulated
formation of a protein known to decrease the risk of heart attack. Obesity
decreases this substance, called adiponectin" - [WebMD]
- See
resveratrol products at Amazon.com.
-
Fish-Oil Supplements Plus Regular Aerobic Exercise Benefit Overweight Patients
- Medscape, 5/22/08 - "FO [fish oil] supplements and
regular exercise both reduce body fat and improve cardiovascular and metabolic
health ... Increasing intake of n-3 FAs could be a useful adjunct to exercise
programs aimed at improving body composition and decreasing cardiovascular
disease risk"
-
Role
of Metformin for Weight Management in Patients Without Type 2 Diabetes (June)
- Ann Pharmacother. 2008 May 13 - "The weight loss
effects of metformin in overweight or obese adults and adolescents without
diabetes appear promising; however, trials have been limited by small patient
populations and weak design. Metformin may also have a positive effect on
metabolic parameters such as waist circumference, fasting insulin and glucose
levels, and triglycerides" - See metformin at at
OffshoreRx1.com.
-
Metformin May Delay Onset of Diabetes in At-Risk Subjects - Medscape,
3/24/08 - "Metformin treatment, compared with
placebo or no treatment, reduced body mass index by 5.3%, fasting glucose by
4.5%, fasting insulin by 14.4%, and calculated insulin resistance by 22.6%
... Metformin treatment also reduced triglycerides and LDL cholesterol by
5.3% and 5.6%, respectively, and increased HDL cholesterol by 5.0% ... The
incidence of new-onset diabetes was reduced by 40% (odds ratio, 0.6), with
an absolute risk reduction of 6%, during a mean trial duration of 1.8 years"
- I don't have diabetes yet still take 1,000 mg of metformin per day. I
still feel high blood sugar and advanced glycation end products are major
causes of aging. See
metformin at OffshoreRx1.com.
-
Obese children may benefit from CLA: study - Nutra USA, 2/29/08 -
"when these results were compared to those from the
placebo tests, CLA improved
fat loss at a rate of 0.024 kg per gram
of CLA per week" - [Abstract]
- Note: 0.024 kg = 0.1 lbs so the normal 3 gram dose would be 0.3 pounds
per week. It might not sound like much but 0.3 x 52 = 15.6 pounds per year.
See
conjugated linoleic acid at Amazon.com.
-
Conjugated linoleic acid reduces body fat accretion and lipogenic gene
expression in neonatal pigs fed low- or high-fat formulas - J Nutr. 2008
Mar;138(3):449-54 - "CLA reduced body fat accretion
regardless of dietary fat content ... Adipose tissue expression of
acetyl-CoA carboxylase-alpha and lipoprotein lipase were significantly
reduced by CLA treatment" - See
conjugated linoleic acid at Amazon.com.
-
Effects
of conjugated linoleic acid and exercise on bone mass in young male Balb/C
mice - Lipids Health Dis. 2006 Mar 23;5:7 -
"Conjugated Linoleic Acid (CLA) has been reported to lower body fat mass.
However, weight loss is generally associated with negative effects on bone
mass, but CLA is reported to have beneficial effects on bone ... a
combination therapy of CLA and EX on bone health has not been studied ...
although CLA decreased gain in body weight by 35%, it however increased bone
mass by both reducing bone resorption and increasing bone formation. EX also
decreased gain in body weight by 21% and increased bone mass; but a
combination of CLA and EX, however, did not show any further increase in
bone mass" - See
conjugated linoleic acid at Amazon.com.
-
Artificial Sweeteners Linked To Weight Gain - Science Daily, 2/10/08 -
"relative to rats that ate yogurt sweetened with
glucose (a simple sugar with 15 calories/teaspoon, the same as table sugar),
rats given yogurt sweetened with zero-calorie saccharin later consumed more
calories, gained more weight, put on more body fat, and didn't make up for
it by cutting back later, all at levels of statistical significance"
-
Green Tea May Ward Off Weight Gain - WebMD. 1/23/08 -
"Here's what those preliminary lab tests in mice
show: ... Less weight and fat gain. Among mice with an obesity gene, those
that ate chow laced with green tea extract gained less weight and less fat
... Less fat in the liver. There was less sign of "fatty liver" disease in
the mice with the obesity gene that ate chow laced with green tea extract
... Lower cholesterol and triglyceride levels in mice with the obesity gene
that ate the chow laced with green tea extract, compared to other mice with
the same obesity gene" - See
green tea extract at Amazon.com.
-
Lipoic Acid Could Reduce Atherosclerosis, Weight Gain - Science Daily,
1/14/08 - "lipoic acid supplements reduced
atherosclerotic lesion formation in two types of mice that are widely used
to study cardiovascular disease, by 55 percent and 40 percent, respectively.
The supplements were also associated with almost 40 percent less body weight
gain, and lower levels of triglycerides in very low-density lipoproteins"
- See
alpha lipoic acid at Amazon.com.
-
Most
Effective Weight Loss Diet Revealed, According To New Study - Science
Daily, 1/11/08 - "a high protein, low carbohydrate
diet is most effective at reducing hunger and promoting weight loss, at
least in the short term"
-
Metformin, Lifestyle
Changes Effective in Antipsychotic-Induced Weight Gain - Medscape,
1/10/08 - "Lifestyle intervention plus metformin had
the greatest effect on weight loss, and metformin alone was more effective
than lifestyle intervention plus placebo in increasing insulin sensitivity
and reversing weight gain in these patients with schizophrenia and
significant weight gain from atypical antipsychotic agents"
-
More support for omega-3 and weight management - Nutra USA, 12/21/07 -
"Laboratory mice fed a high fat diet and
supplemented with eight per cent fish oil gained less weight and metabolised
more fat than their murine counterparts not receiving the supplement"
- [Abstract]
- See Mega Twin EPA at Amazon.com.
-
Kids: Less Sleep May Lead to Overweight - WebMD, 11/5/07
-
Effects of milk supplementation with conjugated linoleic acid (isomers
cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic
syndrome components - Br J Nutr. 2007 Jul 11;:1-8 -
"Subjects were randomised to a daily intake of 500
ml milk supplemented with 3 g CLA (using a mixture of the bioactive isomers
cis-9, trans-11 and trans-10, cis-12, marketed as Tonalin(R), Naturlinea;
Central Lechera Asturiana) or placebo for 12 weeks ... The supplementation
of milk with 3 g CLA over 12 weeks results in a significant reduction of fat
mass in overweight but not in obese subjects. CLA supplementation was not
associated with any adverse effects or biological changes" - See
conjugated linoleic acid at Amazon.com.
-
Biology Dictates Diet Success - WebMD, 5/15/07 -
"The low-glycemic-load diet was effective for a lot
of the individuals who were high-insulin secretors and who previously had
challenges losing weight and keeping it off"
-
Soup First Cuts Calories Later - WebMD, 5/1/07 -
"Participants consumed 20% fewer calories when they
started their meals with soup"
-
Diets Don't Work Long-Term - WebMD, 4/11/07
-
Study Examines Calorie Restriction and Glycemic Load - Doctor's Guide,
4/10/07 - "Unlike several other long-term studies,
which have reported greater weight loss with low GL diets at six months but
no differences by 12 months, our data show no significant short-term or
long-term differences"
-
Report: Green Tea - Natural Support For Healthy Weight Control - Life
Extension Magazine, 4/07 - "Strong scientific
evidence suggests that green tea confers critical cardiovascular benefits,
may protect against a variety of deadly cancers, reduces the risk of
diabetic complications, and may mitigate the effects of various autoimmune
disorders ... If these broad-spectrum benefits were not reason enough for
health-conscious adults to consider adding green tea to their daily
supplement regimen, emerging research that confirms green tea’s effects in
facilitating fat burning, weight management, and optimal body composition
surely is"
-
Obesity Surgery Can Lead To Memory Loss, Other Problems - Science Daily,
3/13/07
-
Atkins Diet Tops Others in Study - washingtonpost.com, 3/6/07 -
"The study by Stanford University researchers
compared the Atkins approach to three others: the standard low-fat, reduced
calorie regimen long recommended by physicians and weight loss experts; the
Zone, a reduced carbohydrate approach developed by author Barry Sears; and
the very low-fat, high-carbohydrate regimen created by physician Dean Ornish
... For all practical purposes the programs all worked about the same ...
The extra four pounds lost by the Atkins group are not very meaningful"
- Another consideration is that you don't know how much of that four pounds
is water loss caused by high protein diets. - Ben
-
Get the diet scoop: 6 promising supplements, 6 to avoid - CNN, 2/16/07 -
"promising ...
Caffeine ... EGCG
...
Chromium ... Conjugated
Linoleic Acid (CLA) ...
5-HTP ... L-dopa or
L-tyrosine"
-
Over-the-Counter Weight Loss Pill OK'd - WebMD, 2/7/07 -
"FDA approved
orlistat capsules -- called "alli" -- as an
over-the-counter weight loss aid for overweight adults ... the pill will be
available in U.S. stores by this summer ... In studies, most people lost
5-10 pounds over six months"
-
Regulator doubts calorie-burning claims of Enviga drink, made by Coke,
Nestle - USA Today, 2/5/07
-
Long-Term Safety
of Diet Drugs Unknown - WebMD, 1/8/07
-
An open-label pilot study of the combination therapy of metformin and
fluoxetine for weight reduction - Int J Obes (Lond). 2006 Sep 12 -
"In a 6.68-month period, a 7.89 kg decrease in
weight (9.32%) and a 3.43 U decrease in BMI (10.14%) were observed in
participants of the case group that was statistically significant"
-
CLA could cut 'weight creep' during holidays, ageing - Nutra USA,
8.22/06 - "the subjects taking CLA safely reduced
their body fat mass by one kilogram (2.2 lbs) and their body weight by 0.6
kg (1.3 lbs). In comparison, those in the placebo group gained 0.7 kg (1.5
lbs) of body fat mass and 1.1 kg (2.4 lbs) of body weight during the months
that are especially problematic for overweight people ... the majority of
studies that have reported positive results have all been performed with
Tonalin CLA… which has a very high concentration of the bioactive isomers
cis-9, trans-11, and trans-10, cis-12" - See
conjugated linoleic acid at Amazon.com.
-
Low
Glycemic Index Diet Best For Weight Loss And Cardiovascular Health -
Science Daily, 7/26/06 - "Between the two
high-carbohydrate diets, lowering the glycemic index doubled fat loss"
-
CLA Weight Loss
Debate Continues - WebMD, 5/22/06 -
"for six months ... Three months into the study, the
CLA group had lost an extra 1.5 pounds of body fat, compared to the
placebo group ... At the study’s end, the CLA group lost 5.6% more body fat
mass than those taking the placebo. The CLA group also lost about 3.3 pounds
more than the placebo group"
- See
conjugated linoleic acid at Amazon.com.
-
Exercise Trumps
Diet for Weight Loss - WebMD, 4/14/06
-
Pine
Nut Oil Boosts Appetite Suppressors Up To 60 Percent For 4 Hours -
Science Daily, 4/4/06 - "CLA
differentially reduces fat mass in men and women in just 3 months ... After
six months, there was an average fat mass loss of 2 kilos corresponding to
about 6% fat loss. At the same time, "overall body weight loss was 'only'
1.5 kilos because there was a gain in muscle mass,"" - See
conjugated linoleic acid at Amazon.com.
-
Vegetarian Diet
May Help Weight Loss - WebMD, 4/3/06
-
Telmisartan But Not Valsartan Increases Caloric Expenditure and Protects
Against Weight Gain and Hepatic Steatosis - Hypertension. 2006 Mar 27 -
"Telmisartan, but not valsartan, promoted increases
in caloric expenditure and protected against dietary-induced weight gain ...
Telmisartan reduced the accumulation of visceral fat and decreased adipocyte
size to a much greater extent than valsartan and was also associated with a
significant reduction in hepatic triglyceride levels"
-
About 5% of Long-term Niacin Users Evolve Into HDL Hyperresponders -
Doctor's Guide, 3/14/06 - "Overall, these patients lost
4% of body weight while on
niacin treatment" - See
iHerb
niacin products.
-
Midnight Snack
Won't Pack Fat - WebMD, 2/2/06 -
"weight gain depends on how many calories we eat,
and not when we eat them"
-
Study Could Lead To A Novel Strategy For Treating Obesity - Science
Daily, 1/16/06 - "Their results suggest that
restoring fatty-acid levels in the brain may be a promising way to treat
obesity"
-
After Gastric Bypass Surgery, Important to Check Vitamin B1 Deficiency -
Doctor's Guide, 12/29/05
-
The Perricone Weight Loss Program
- Life Extension Magazine, 11/05 -
"The reason that traditional low-calorie diets fail
is that they lack omega-3s, which are essential for healthy metabolism. If
you follow the anti-inflammatory diet and ensure the intake of plenty of
omega-3 fatty acids, you will successfully lose weight" - See Mega
Twin EPA at
iHerb.
-
Getting Older Without Adding Extra Weight - WebMD, 10/3/05
-
Low-Fat, Vegan Diet May Be Effective for Weight Loss - Medscape, 9/15/05
-
"14-week trial reported in the September issue of the
American Journal of Medicine ... Mean body weight decreased by 5.8 +/- 3.2
kg in the vegan group and by 3.8 +/- 2.8 kg in the control group"
- Note: 5.8 kg is 12.8 pounds, 3.8 kg is 8.4 pounds. 12.8 - 8.4 = 4.4
pounds more weight loss in the vegan group after 14 weeks. [Abstract]
-
New Study Shows High-Carb, Vegan Diet Causes Major Weight Loss -
Doctor's Guide, 9/9/05 - "A low-fat, plant-based
diet is more effective at helping women lose weight and improve insulin
sensitivity than an omnivorous diet ... a low-fat, primarily vegan diet may
slow the progression of prostate cancer"
-
Breakfast Cereal Helps Maintain Healthy Weight - WebMD, 9/1/05 -
"In a study of girls followed from age 9 to age 19,
regular cereal eaters had fewer weight problems than infrequent cereal
eaters"
-
Diet Soda
Surprise May Not Be So Slimming - CBS 2 Chicago, 8/23/05 -
"people who were drinking diet soft drinks two or
more per day had a 57 percent chance of becoming overweight by a seven- to
eight-year follow-up, which was significantly higher than the people who are
drinking regular soft drinks"
-
Research May Provide New Link Between Soft Drinks And Weight Gain -
Science Daily, 8/2/05 - "Those consuming the
fructose-sweetened water showed significant weight gain over the course of
the study, with an average final weight of 48 grams—compared with averages
below 44 grams for the other groups—and had about 90 percent more body fat
than the mice that consumed water only"
-
Weight Loss and Other Benefits of Conjugated Linoleic Acid
- Life Extension Magazine, 6/05 -
"Researchers concluded that a dose of 3.4 grams
results in significant body-fat loss compared to placebo, but that greater
amounts of CLA do not result in greater fat loss" - See
conjugated linoleic acid at Amazon.com.
-
Magic
Pill? - CBS 2 Chicago, 5/20/05 -
"What some people believe is a magic pill to fight
fat is a supplement called hoodia, which claims to suppress your appetite"
-
Vertical Gastrectomy Suggested as Weight-Loss Procedure of Choice for Older
Obese Patients - Doctor's Guide, 5/20/05
-
Consumer Reports Rates Diet Plans - WebMD, 5/9/05 -
"Weight Watchers got the highest rating. On the 1 to
5 rating scale -- where 5 is best and 1 is worst -- Weight Watchers scored a
4"
-
Skipping Exercise Makes Fat a Bigger Problem - WebMD, 4/19/05 -
"Just five hours after exercise stopped, the rat's
abdominal fat cells started to send off chemical signals that made them
start to swell. After two days of no exercise, the fat cells got 19% larger
-- and the rats' stomach fat got 48% heavier"
-
Low-Carb Diets: More Protein May Not Help - WebMD, 4/15/05
-
Supplement Shows Promise for Body Fat Loss - WebMD, 4/1/05 -
"The group that had already been taking
CLA lost no more weight or body fat, but they maintained the body fat
losses seen in the previous year. People who began taking the supplement
during year two of the study lost an average of 3.5 pounds and also saw
reductions in overall body fat" - See
conjugated linoleic acid at Amazon.com.
-
Yogurt May Help Burn Fat, Promote Weight Loss - WebMD, 3/17/05 -
"obese adults who ate three servings of fat-free
yogurt a day as part of a reduced-calorie diet lost 22% more weight and 61%
more body fat than those who simply cut calories and didn't bone up on
calcium. Yogurt eaters also lost 81% more fat in the stomach area than
non-yogurt eaters"
- Hoodia for Weight Loss?
- Dr. Weil, 3/11/05
- Green Tea: The
Next Performance Enhancer? - WebMD, 1/28/05 -
"Ten weeks of green tea supplements plus strenuous
exercise made mice swim longer and stronger than mice that swam their laps
without performance enhancement ... The mice got stronger because the green
tea made them burn fat more efficiently ... the amount of green tea eaten by
the mice would work out to about 4 cups of green tea a day for a 165-pound
human athlete"
- See
green tea extract at Amazon.com.
- Think twice about
weight-loss surgery - MSNBC, 1/28/05
- Green Tea Fights
Fat - WebMD, 1/26/05 -
"the first group drank a bottle of oolong tea
fortified with
green tea extract containing 690 milligrams of
catechins, and the other group drank a bottle of oolong tea with 22
milligrams of catechins ... After three months, the study showed that the
men who drank the green tea extract lost more weight (5.3 pounds vs. 2.9
pounds) and experienced a significantly greater decrease in BMI, waist size,
and total body fat" - See
green tea extract at Amazon.com.
-
Weight-Loss Supplements: Do They Work? - HealthDay, 1/15/05
- Less Sleep Could
Mean More Weight - WebMD, 1/10/05 -
"Total sleep times tended to decrease as body weight
increased ... The difference in total sleep time between patients who were
normal weight and those who weren't was only 16 minutes per day"
- Sleep Loss Feeds
Appetite - WebMD, 12/7/04
-
Healthy Carbs, Fats for Weight Loss
- WebMD, 11/23/04 -
"eating a so-called low-glycemic diet may overcome
the body's natural tendency to slow metabolism when calories are restricted.
A low-glycemic diet emphasizes healthy fats and carbohydrates"
-
Water-Rich Diet More Effective Than Low-Fat Regimen for Weight Loss -
Medscape, 11/18/04
-
Egg Breakfast May Help Weight Loss Diet
- WebMD, 11/18/04
- High- and Low-Carb
Diets Produce Similar Results - Medscape, 11/17/04 -
"A rare head-to-head comparison of a high glycemic
index (GI)/high-carbohydrate diet with a low-GI/low-carbohydrate diet
resulted in comparable weight loss and increase in insulin sensitivity"
-
Low-Fat Diet Best for Lasting Weight Loss
- WebMD, 11/16/04
-
Sleep More to
Fight Obesity - WebMD, 11/16/04
-
Study: Low-Fat Diets Better Long-Term - Intelihealth, 11/16/04 -
"Regardless of how they shed pounds in the first
place, big losers stayed that way by limiting fat rather than carbohydrates"
-
Want to Cut
Calories? Just Add Water - WebMD, 11/15/04
-
Portion Control Pays Off in Weight Loss
- WebMD, 10/15/04
-
Portion Control Induces Greatest Weight Loss in Obese Patients -
Doctor's Guide, 10/14/04 -
"Although we saw similar patterns of weight loss
related to reduced dietary fat consumption, increased fruit and vegetable
consumption, increased physical activity and increased planned exercise, the
target behavior that induced the greatest weight loss was portion control"
-
Novel Fiber Limits Sugar Absorption - Life Extension Magazine, 9/04 -
"Life Extension recommends that people seeking to
lose weight consume the following supplements: ...
Chromium
polynicotinate 600-1000 mcg daily ... Conjugated linoleic acid (CLA)
3000-4000 mg daily ...
PGX™ highly viscous fiber blend 1000-3000 mg 5-10
minutes before each meal with 8-16 ounces of water ... Consider asking your
doctor to prescribe 500 mg two to three times daily of the
insulin-normalizing drug metformin"
-
Vitamin Supplements May Slow Middle-Age Weight Gain
- HealthDay, 9/10/04 -
"the people who had taken multivitamins, vitamin
B-6, vitamin B-12 and chromium had less weight gain over the previous 10
years than other respondents"
-
Low-glycemic-index plan is better than low-fat or low-carb diets, study says
- HealthDay, 8/26/04 -
"After two to four months, the researchers found
that the rats given the high-glycemic-index
diet had 71 percent more body fat and 8 percent less lean muscle mass,
compared with rats on the low-glycemic-index diet"
-
Sick of Low-Carb Diets? Try Low-GI
- WebMD, 8/26/04 -
"The animals on the high-GI
diet were gaining more weight with same amount of food, and we had to
cut their food back increasingly over time to keep them at the same weight
... But what was really interesting to us was that even though they
maintained the same weight because they got less food, the high-GI group in
both rats and mice doubled their body fat and had a reduction ... in muscle
mass, which is exactly what you don't want"
-
Grapefruit Lowers Weight, Fights Cancer - HealthDay, 8/25/04 -
"At the end of 12 weeks the placebo group lost on
average just under half a pound, the extract group 2.4 pounds, the
grapefruit juice group 3.3 pounds, and the fresh grapefruit group 3.5 pounds
... In this study they had one and a half grapefruits a day"
-
Six Patterns for Weight Loss Management
- WebMD, 8/4/04
-
Whey protein better than meat for reducing body weight
- Nutra USA, 6/7/04 -
"Increasing the dietary density of
whey protein, but not of red meat, reduced body
weight gain by 4 per cent, they add, while whey protein also reduced plasma
insulin concentration by 40 per cent and increased insulin sensitivity,
compared to meat protein" - See
iHerb
whey protein products.
-
CLA: The New Miracle Weight Loss Pill?
- WebMD, 5/24/04 -
"Both CLA
groups lost weight -- about 4 pounds; the placebo group stayed the same ...
The CLA syrup group had a 9% body fat loss; the CLA pill group had 7% loss;
the placebo group had no body fat loss ... The increased lipoprotein levels
may be a byproduct of fat loss, says Gaullier. "The body does show
inflammation caused by the process of eliminating fat. We think this is what
is happening, but we don't know for certain.""
[Abstract]
- See
conjugated linoleic acid at Amazon.com.
-
Weight Watchers Tend To Keep Pounds Off
- WebMD, 4/8/04 -
"That's not the story with Weight Watchers weight
losers. The study shows that after two years, three-fourths of their lost
weight stays lost. After five years, half the lost weight was still gone ...
people who lose weight and keep it off -- whether they are on Weight
Watchers or not -- have several things in common: ... They take in 1,400
calories a day: 56% from carbs, 24% from fat, and 20% from protein"
-
A Safer Gastric Bypass Surgery - HealthDay, 4/7/04
-
Evidence-based Products - Functional Foods and Nutraceuticals, 4/04 -
"The first received
Super CitriMax at 2,800mg HCA per day ...
After eight weeks, the first group lost 6.2 per cent of body weight and
reduced BMI by 6.3 per cent" - See
Super CitriMax products at iHerb.
-
What makes people fat, why diets don't work, and what triggers appetite?
- Dr. Murray's Natural Facts, 3/17/04 -
"PGX™ lowers after meal blood sugar levels by
approximately 20 to 40% and also lowers insulin secretion by approximately
40% producing a whole body insulin sensitivity index improvement of nearly
50% - a phenomenal accomplishment that is unequalled by any drug or natural
health product.10 PGX™ is particularly well-suited for syndrome X" -
See
PGX at Amazon.com
PGX products.
-
More Carbs, More Exercise = More Weight Loss
- WebMD, 3/5/04 -
"The thinnest people eat the most carbs ... Without
exception, a high-complex-carbohydrate, high-vegetable-protein diet is
associated with low body mass ... High-protein diets were associated with
higher body weight"
-
Kids Who Eat Too Much Fat, or Too Little, Prone to Weight Gain
- HealthDay, 3/4/04
-
Green Tea Boosts Metabolism Without Increasing Heart Rate - Clinical
Psychiatry News, 3/04 -
"Patients took two 375-mg capsules twice daily, for
a total daily epigallocatechin gallate dose of 270 mg ... By week 12, body
weight decreased by a mean of 4.6% and waist circumference by 4.48%"
- See
green tea extract at Amazon.com.
-
Growth Hormone May Be Fat Fighter - WebMD, 2/13/04 -
"the dosage of growth hormone was increased to 400
µg per day in men and 600 µg in women ... those who used growth hormone lost
an average of about 5 pounds and kept it off for up to nine months.
Researchers say the weight loss was entirely caused by a loss of body fat
... growth hormone improved cholesterol profiles -- increasing the level of
"good" HDL cholesterol by 19%" - Maybe my math is off but I calculate
500 micrograms to be 1.5 IU (0.5 mg/5mg = x /15 IU, x = .5 mg * 15 IU/5 mg,
x = 1.5 IU) - Ben
-
Is Weight Loss Surgery Too
Risky? - Dr. Weil, 2/10/04
-
HCA, better than ephedra? - Nutra USA, 2/4/04 -
"study’s principal investigator, Dr Harry Preuss of
Georgetown University Medical Center ... Super CitriMax performed a function
not noted in ephedra however - it significantly increased serum serotonin
levels (a mechanism of appetite control and eating behavior) and lowered
serum leptin levels, a biomarker of the gene that regulates obesity"
- See
Super CitriMax products at iHerb.
-
Dieters Decrease Heart Risk on Moderate Fat Program
- Doctor's Guide, 1/29/04 -
"Over the course of the study, the low-fat diet
group experienced a 12 percent decrease in HDL ("good") cholesterol but the
moderate-fat diet group had no change. This indicates that a moderate-fat
diet blunts the decrease in HDL ("good") cholesterol during weight loss"
-
Study Links High-Carbs And Weight Loss
- Intelihealth, 1/27/04
-
More Carbs, Less Weight - HealthDay, 1/26/04 -
"assigned to one of three 12-week programs ... They
were told they could eat as much as they wanted ... Participants in the
low-fat, high-carb groups lost weight and those who exercised lost even
more. The average weight loss was almost 11 pounds"
-
Atkins, South Beach or Dr. Phil? An expert rates the books
- USA Today, 1/15/04
-
Supplement Solutions For Weight Loss - Natural Foods Merchandiser, 1/04
-
Drinking Water May Speed Weight Loss
- WebMD, 1/5/04 -
"The researchers estimate that over the course of a
year, a person who increases his water consumption by 1.5 liters a day would
burn an extra 17,400 calories, for a weight loss of approximately five
pounds"
-
Eating Cereal Helps Kids Control Weight - HealthDay, 12/8/03 -
"for children who ate cereal eight or more times
during the two weeks of the study, the risk for being overweight was reduced
to one in five. For those who ate little cereal, the risk increased to
almost one in two"
-
Weight Control Doesn't Have to Be a Battle - HealthDay, 11/2/03
-
Stomach Pacemaker May Be Low-Risk Option
- WebMD, 10/16/03
-
Meal Replacement Plans Do Work - HealthDay, 10/13/03 -
"People who followed a meal replacement plan for 10
years weighed, on average, about 33 pounds less than people who didn't use a
meal replacement plan"
-
Moderate Exercise as Effective as Intense Workouts for Dropping Pounds -
WebMD, 9/9/03 -
"along with dieting, when overweight women started a
new exercise routine after years of being inactive, it didn't really matter
whether they came out of the gate running or walking briskly. After a year,
there was only a total weight-loss difference of 1 1/2 pounds between them"
-
Dietary Experts Debate Carbohydrates
- Intelihealth, 9/2/03 -
"Blood sugar levels may shoot twice as high after a
high-GI meal as after a low one, and that
unleashes metabolic havoc: The body responds with a surge of insulin, which
prompts it to quickly store the sugar in muscle and fat cells. The high
sugar also inhibits another hormone, glucagon, which ordinarily tells the
body to burn its stored fuel ... Blood sugar plunges. So much is stored so
fast that within two or three hours, levels may be lower than they were
before the meal. Suddenly, the body needs more fuel. But because glucagon is
still in short supply, the body does not tap into its fat supply for energy.
The inevitable result? Hunger ... After one year, the low-GI volunteers had
dropped seven pounds of pure fat. The others had put on four"
-
Eating Breakfast Strengthens Fight Against Obesity
- Physician's Weekly, 9/1/03 -
"people who regularly skip breakfast are 4.5 times
more likely to be overweight and those who eat four or more meals per day
are less likely to be overweight. The study also found that Americans who
eat later during the day are no more likely to be overweight than those who
do not"
-
French Secrets to Staying Slim - WebMD, 8/22/03 -
"Only 7% of French people are obese, compared with
30% of Americans ... The average portion size in Paris was 25% smaller than
in Philly ... Chinese restaurants in Philly served meals that were 72%
bigger than Parisian Chinese restaurants"
-
New Diet Approach May Fight Child Obesity
- WebMD, 8/12/03 -
"a reduced-glycemic-load diet that emphasizes foods
with a low to moderate
glycemic index and allows children to eat
until they're full was more effective than a traditional low-fat,
calorie-restricted diet in helping obese children shed pounds and slow the
progression of insulin resistance, a risk factor for diabetes ... Complex
carbohydrates, such as whole-grain bread and cereals, brown rice, and
vegetables, are foods with a low to moderate glycemic index"
-
Could a Pill Treat Obesity and Lower Cholesterol?
- HealthDay, 7/29/03
-
Thyroid boost may speed weight loss - USA Today, 7/28/03
-
Skip Breakfast, Get Fat - HealthDay, 7/11/03 -
"late eaters are no more likely to be overweight
than anyone else ... Americans who regularly skip breakfast are 4.5 times
more likely to be fat ... those who eat four or more meals a day are
actually on the thinner side ... people who ate more than three times a day
were about half as likely to be fat as those who ate three or fewer times a
day. Ma suspects the difference may have something to do with fewer spikes
in blood sugar levels among the frequent eaters"
-
Growth Hormone May Help Obesity - HealthDay, 6/27/03 -
"gave small doses of
growth hormone to 39 people who were
about 40 percent overweight. The volunteer participants lost an average of
slightly more than 5 pounds ... Growth hormone, they believe, helps control
appetite and speeds up the metabolism, which burns calories. When people are
obese, the amount of growth hormone in their bodies decreases, which
contributes to the accumulation of fat and loss of muscle mass. That, in
turn, may sap the person's energy to exercise"
-
Obese Individuals Experience Modest Weight Loss with Growth-Hormone Therapy
- Doctor's Guide, 6/24/03 -
"9-month study ... were encouraged to slowly lose
weight by exercising and reducing their daily caloric intake by 500
calories. Twenty-three subjects self-injected
growth hormone nightly and 17
self-administered placebo injections ... People who took growth hormone lost
an average of 2.4 kg, or 5.25 pounds. This weight loss was all due to loss
of body fat; they did not lose any muscle mass ... Most of the fat loss was
in the
abdominal area. There were also improvements
in high-density lipoprotein cholesterol of about 19%"
-
Anticonvulsant Might Prevent Recidivism after Weight Loss
- Doctor's Guide, 6/17/03
-
High Protein Diets More Effective At Maintaining Weight Loss
- Doctor's Guide, 6/4/03 -
"Despite no differences in attitudes to eating, a
protein intake of 18% as energy versus 15% as
energy resulted in improved weight maintenance, as well as improved fat
distribution based on body waist circumference, and improved substrate
oxidation and satiety"
-
Epilepsy Drug [topiramate] Has Weight Loss Effect, But Adverse Events Stop
Study - Doctor's Guide, 6/3/03 -
"Patients on two of three higher doses used in the
study (192 mg and 256 mg) had a mean weight loss of 12-13 kg [12.5 kg = 27.5
pounds] when the study was ended. At this time the patients had been taking
the drug for between 60 and 76 weeks. By comparison, patients in the placebo
arm lost a mean of 2.9 kg. These losses corresponded to a mean decrease of
12% to 13% from baseline for the two highest dose groups ... If further
trials also show this [result],
topiramate would be the first
drug with such a long term weight loss effect ... 19% of patients withdrew
because of side effects. Mild to moderate
paresthesia was
the most common" - See
OffshoreRx1.com or
drugstore.com.
-
Orlistat Keeps The Weight Off Over Three Years In Metabolic Syndrome
Patients - Doctor's Guide, 6/3/03 - See
online prescriptions.
-
Low-Carbohydrate Diet Better Than Low-Fat for Weight Loss, Insulin
Sensitivity, and Triglycerides - Doctor's Guide, 5/29/03
-
Red Meat May Be Key to High-Protein Diet
- WebMD, 5/9/03 -
"100 women were enrolled in the study -- all
overweight, with an average body mass index (BMI) of 33. For 12 weeks, half
the women ate a high-protein diet of 34% protein, 46% carbohydrate, and 20%
fat. The other half ate a high-carbohydrate diet that was 17% protein, 64%
carbohydrate, and 20% fat ... Each diet consisted of about 1, 340 calories,
and protein in both diets was from lean red meat ... the high-protein-diet
women lost substantially more weight ... the high-meat eaters also had 22%
lower levels of triglycerides ... Bottom line: Eat fewer refined
carbohydrates -- table sugar, baked goods, white bread, pasta -- and more
fruits and vegetables ... Eat lots of lean protein -- sirloin steak, flank
steak, chicken, eggs, tofu, and fish"
-
Shedding Pounds Not as Tough as You Think - HealthDay, 5/9/03
-
Had it with High Carbs? -
Dr. Weil, 5/2/03
-
Low-Carb Diets Work Without Boosting Heart Risk - HealthDay, 4/18/03 -
"after six months, the 22 women on the low-carb plan
averaged an 18.7-pound loss, while the 20 women on the low-fat plan averaged
an 8.5-pound loss ... The low-carbohydrate group, at the three-month mark,
was averaging 15 percent of calories from carbohydrates, 28 percent from
protein and 57 percent from fat. At the six-month mark, they were eating 30
percent carbs, 23 percent protein and 46 percent fat ... The low-fat group
was averaging 54 percent of calories from carbohydrates three months into
the study, 18 percent from protein and 28 percent from fat. At six months,
the totals were 53 percent carbs, 18 percent protein and 29 percent fat ...
Average calorie intake was similar for both groups -- 1,302 a day for the
low-carb group after six months and 1,247 for the low-fat group"
-
Yogurt May Help Burn Fat - HealthDay, 4/18/03
-
The Dairy Calcium in Yogurt Helps People Lose Belly
- WebMD, 4/15/03 -
"put 34 obese people on a low-cal diet. Sixteen of
them got pills with 400 to 500 mg of
calcium per day. The other 18 people ate enough yogurt to give them 1100
mg of calcium per day ... After 12 weeks, everybody lost a lot of fat ...
Sixty percent of the yogurt eaters' weight loss was
belly fat, while only 26% of the comparison
group's loss was belly fat"
-
Calcium Helps Girls Keep the Weight Off - HealthDay, 4/14/03 -
"Whether
calcium comes from dairy products or
supplements, girls who consume the highest levels weigh less than girls who
consume lower levels ... as little as a daily increase of one cup of milk or
a small piece of cheese, about 300 milligrams of calcium, resulted in
one-half inch less of abdominal fat and as much as two pounds less of body
weight. "I have reason to believe that the same effect occurs in boys,""
-
Calcium for Weight Loss? - WebMD, 4/14/03
-
Commercial Diet Programs Beat Do-It-Yourself Ones
- HealthDay, 4/8/03 -
"At the end of the first year, the self-help group
lost and maintained 2.86 to 3.08 pounds. By the end of the second year,
however, the weight was back to what it had been at the beginning of the
study ... The Weight Watchers group lost 9.46 to 11 pounds by the end of the
first year, and 5.94 to 6.6 pounds overall by the end of the second year"
-
You Can Trim Down Online - HealthDay, 4/8/03 -
"people in the e-mail counseling group lost more
than twice as much weight as those just using the basic Internet weight-loss
program. At the end of a year, the people in the e-mail counseling group
lost an average of 10 pounds while those in the basic program lost an
average of 4 pounds"
-
Intermittent and On-Demand Very Low Calorie Diets Bring Significant Weight
Loss - Doctor's Guide, 4/3/03 -
"All patients started with 16 weeks on a very low
calorie diet. Then, patients assigned to an intermittent group were
scheduled to use a very low calorie diet for two weeks every third month,
while patients in an on-demand group were told to use a very low calorie
diet whenever their body weight passed an individualized cut-off level ...
Completers in both groups maintained highly significant weight losses after
two years. Patients in the intermittent group lost 7.0 [15.43 pounds] +/-
11.0 [24.25 pounds] kg. Patients in the on-demand group lost 9.1 [20.06
pounds] +/- 9.7 [21.38 pounds] kg"
-
Meal Replacement Diet Keeps Weight Off
- thesandiegochannel.com, 3/28/03 -
"The group that lost more used meal replacements"
-
Cardiovascular Risk Factors Affected By Diet
- Doctor's Guide, 2/27/03 -
"Although patients were advised to maintain an
identical energy intake with the different diets, there was significant
weight loss on the low
glycaemic index diet compared with weight gain
on the high sucrose diet"
-
Band-Associated Re-Operation Common, But Safe, After Laparoscopic Gastric
Banding - Doctor's Guide, 2/19/03
-
Light Sleeper, Heavy Gainer - HealthDay, 2/14/03 -
"Sleep loss can result in
high blood levels of glucose, which causes your body to overproduce
insulin and makes it easier to gain weight ... Sleep deprivation can
increase production of
cortisol, a stress hormone that stimulates the
appetite ... Lack of sleep can lead to a
growth hormone
deficiency, which can cause you to put on fat, rather than muscle"
-
The Great Weight Debate - WebMD, 2/6/03
- Diglyceride-Rich
Foods May Promote Weight Loss - New Hope Natural Media, 1/30/03 -
"79 obese men and women from ages 19 to 75 were
assigned to incorporate specific food products that contained high amounts
of diglycerides (from rapeseed oil, also known as
Canola oil) or
triglycerides (from rapeseed, soybean and safflower oils) in their diets
for 24 weeks. All participants were put on a low-calorie diet that contained
30% to 35% of energy as fat, 45% to 50% of energy as carbohydrate, and 15%
to 20% of energy as protein ... Body weight and total fat mass decreased
significantly in the group consuming diglycerides by almost 4% and 8%,
respectively, compared with those consuming triglycerides"
-
Bupropion May Aid Weight Loss - Clinical Psychiatry News, 1/03 -
"Of those in the
bupropion group, 52% lost at
least 5% of their body weight during the 26-week study, compared with 15% of
the placebo group" - Bupropion is available online as
Zyban.
-
A New Option for Weight Loss Surgery
- WebMD, 1/21/03
- Adjustable Gastric
Band Safe, Effective in Severe Obesity
- Medscape, 1/21/03
-
CLA for weight loss and diabetes - Life Extension Magazine, 1/03 -
"CLA
supplementation has been shown to improve the lean mass to body fat ratio,
decreasing fat deposition, especially in the abdomen and enhancing muscle
growth" - See
conjugated linoleic acid at Amazon.com.
-
Acute Fast Does Not Induce Compensatory Energy and Nutrient Intake -
Doctor's Guide, 1/2/03
-
Dramatic Weight
Loss Isn't Risky For Men - WebMD, 12/9/02
-
Bariatric Surgery Used On Obese Kids
- Intelihealth, 11/4/02
- Weight Loss
Surgery Adds Years to Life - WebMD, 10/11/02
-
A Weight Loss Pill
[phentermine] that Works? - Dr. Weil, 9/24/02
-
Topiramate shows promise as weight-loss drug
- Doctor's Guide, 9/2/02 -
"A six-month trial of the antiepileptic drug
topiramate (TOPAMAX,
Ortho-McNeil Pharmaceutical, Inc) for the treatment of obesity has found the
drug helped reduce body weight between 6 percent and 8 percent ... weight
loss continued at the six-month cut-off point. In contrast, he said, the two
weight-loss drugs currently on the market, orlistat
(Xenical, Roche) and
sibutramine (Meridia, Abbott Laboratories)
plateau between three and six months ... The most common side effects were
parasthesia, memory difficulty, fatigue, somnolence, appetite loss, taste
perversion, concentration difficulty and dizziness"
-
Dining out without guilt - USA Today, 8/26/02
-
Stepping up the weight loss - USA Today, 8/26/02 -
"Some of the most intriguing answers have been
discovered by studying people in the National Weight Control Registry, a
group of more than 3,000 people who have maintained a 30-pound weight loss
for a year. Registry members lost weight in different ways, but they
generally keep it off by exercising for about an hour a day, eating a
relatively low-calorie, low-fat diet, weighing themselves regularly, having
breakfast every day and keeping track of what they eat ... Brownell says
that if people watch portion sizes, eat fruits and vegetables and less junk,
"they'd be 90% of the way toward a healthy diet." And "if anything has
become clear over the past 10 years, it's the importance of exercise in
weight loss and maintaining.""
-
Nutrition watchdog praises fast food giants
- USA Today, 8/26/02 -
"Low-fat Select Sub sandwiches served at Subway
"have helped lead the way to healthier fast food," the center said. The
statement singled out the low-fat Honey Mustard Ham, Sweet Onion Chicken
Teriyaki and Red Wine Vinaigrette Club sandwiches as "downright delicious"
with calorie counts ranging from 310 to 370 with six grams of fat or less"
-
Scientists Discover Hormone [PPY3-36] That Helps Curb People's Appetites
- Intelihealth, 8/7/02
- 'Fullness'
Hormone Suppresses Appetite - WebMD, 8/7/02
-
Low-Carbohydrate, High-Protein Diets Increase Risk Of Kidney Stones And May
Raise Bone Loss Risk - Doctor's Guide, 8/1/02 -
"acid excretion - a marker for the acid load in the
blood - increased as much as 90 percent while subjects were on
diets that severely restricted
carbohydrates. Levels of urinary citrate,
which inhibits
kidney stones, fell by almost 25 percent
in the group during the six-week study ... People may lose weight on this
diet, but this study shows that this is not a healthy way to lose weight ...
there was an increased risk of developing kidney stones and a possible
increase in the risk of
bone loss"
-
The Benefits of Carnitine and DHEA for Fat Metabolism - Life Extension
Magazine, 8/02 -
"Carnitine
is an amino acid that's critical for converting fatty acids into fuel.
Because of this, it has the potential to help people lose weight ... A lack
of DHEA may be one of the primary causes of
insulin resistance"
-
Reduction of Left Ventricular Hypertrophy After Exercise and Weight Loss in
Overweight Patients With Mild Hypertension
- Doctor's Guide, 7/15/02 -
"Blood pressure fell
by 7.0 / 6.0 mmHg in the weight management group and by 3.0 / 4.0 mmHg in
the aerobic
exercise group"
-
New
Weight-control Options - Functional Foods & Nutraceuticals, 7/02
-
Losing Weight with Peanut
Butter? - Dr. Weil, 7/10/02 -
"a diet high in monounsaturated fats (MUFAs) with
34-36 percent of calories from fat reduced LDL (���bad”)
cholesterol by 16-25 percent without
lowering
HDL (“good”) cholesterol levels. In contrast, the
American Heart Associations diet with 25 percent of calories from fat,
resulted in only a 12 percent reduction ... people on a diet including 35
percent of calories from MUFAs as well as those on a traditional low-fat,
high carbohydrate diet lost an average of 11 pounds over six months.
However, by 18 months, three times as many people on the MUFA diet remained
with the program and kept off the lost weight while the others regained an
average of five pounds each"
-
Designer
Weight-Loss Drugs on Horizon - WebMD, 6/10/02 -
"In mouse studies, it reduces appetite and makes the
body burn fat faster. That's supposed to be impossible ... Kuhajda and
colleagues at Baltimore's Johns Hopkins University saw obese mice lose 15%
of their body weight after only two weeks on C75. Oh, yes, and there's one
more thing about it: C75 also kills cancer cells ... But don't run out to
the pharmacy looking for the drug. It's years away from any kind of human
trial"
-
Weighing in on
Low-Fat Processed Foods - WebMD, 6/10/02 -
"Many people don't understand that many of these
low-fat products are really very calorie-dense ... There is a tendency to
think that if something is low in fat you can eat as much as you want ...
The key to losing weight and keeping it off is eating smaller portions and
increasing physical activity"
- New Hope for Morbid
Obesity - Medscape, 5/23/02
-
Strength
Training, Modest Diet Fight Child Obesity - WebMD, 5/23/02
-
Secrets of
Successful Weight Loss - WebMD, 5/10/02
-
Band constricts the cravings, weight
- USA Today, 5/9/02
-
Consumer Reports reveals successful diet tips
- CNN, 5/6/02 -
"an overwhelming majority of "successful losers"
took a do-it-yourself approach and credited exercise -- not food deprivation
-- as their top strategy"
-
Americans' new craving: Diet drugs
- USA Today, 4/29/02
-
New Evidence That Dietary Soy And Flaxseed Have Positive Effect On Obesity
And Diabetes - Intelihealth, 4/22/02 -
"These data suggest that diets rich in soy protein
and
flaxseed have beneficial effects on many aspects of
obesity and diabetes"
-
Diet Supplement
[LipoKinetix] Causes Liver Damage - WebMD, 3/18/02
-
High-Protein Beats High-Carbohydrate for Weight Loss in Low-Fat Diets -
Doctor's Guide, 2/26/02
-
The Skinny on Fat
Drugs - WebMD, 2/20/02
-
Breakfast Helps Keep Weight Off - kgtv.com, 2/7/02
-
Five Tips For Planning And Losing Weight
- Intelihealth, 2/6/02
-
Insulin Pill
Fights Obesity - WebMD, 1/31/02
-
Study: Adults Have Obesity Syndrome
- Intelihealth, 1/16/02
-
Cancer Therapy May Have Application For Treating Obesity
- Intelihealth, 1/7/02 -
"Rupnick tested five different angiogenesis
inhibitors, including TNP-470, angiostatin and endostatin, on ob/ob mice and
other obese mice ... The most surprising thing was that not only did the
mice stop gaining weight, they also lost a significant amount of weight ...
Depending on the dose, "we decreased their body weight by almost half -
that's enormous," Rupnick said. The drugs were working far better than any
approved obesity drug ever had""
-
Diabetes Drug
[Glucophage/metformin] May Fight Obesity - WebMD, 12/26/01 -
"Pediatricians at the University of Tennessee School
of Medicine put 24 obese adolescents on a low-calorie diet: 1,500 calories a
day for the girls and 1,800 calories a day for the boys. They also gave half
the teens Glucophage and half a placebo ... After eight weeks, dieting teens
who took the placebo lost 3.8 % of their body weight. But those taking
Glucophage lost 6.5 % of their body weight -- nearly twice as much"
-
More Good News
on Zyban and Smoking - WebMD, 9/20/01 -
"The antidepressant Zyban (also known as Wellbutrin
or by its generic name bupropion) has helped many people quit. Now, research
shows the drug seems to prevent relapse and even seems to help women lose
weight"
-
Losing 100, the
Healthy Way - WebMD, 9/18/01
-
How They Do It: Researchers Study People Who Lost Weight And Keep It Off
- Intelihealth, 9/13/01
- Wellbutrin (Bupropion)
Effective For Weight Loss in Women
- Doctor's Guide, 9/12/01
-
Obesity drugs alone won't do it - CNN, 8/22/01
-
Research
Pipeline Bulging With Obesity Drugs - WebMD, 7/26/01
-
How Successful Dieters Keep Weight Off
- Intelihealth, 7/18/01
-
Wider Use for
Obesity Surgery Urged - WebMD, 7/12/01
- Troglitazone Drug Helps
non-Diabetic Patients Lose Weight
- Doctor's Guide, 6/20/01
-
FDA Approves
Implanted Stomach Band to Fight Obesity, Device Could Be Helpful, But Users
Still Need to Diet and Exercise - WebMD, 6/5/01
-
Stomach
Pacemaker Zaps Obese Patients Slim, Electrical Gadget Helps Overeaters Feel
Full, Eat Less - WebMD, 5/25/01
-
Experimental
Nasal Spray Could Help Keep the Pounds Off - WebMD, 4/27/01 -
"All three agents were inhaled through the nose
twice a day for six weeks ... At the end of the study, body fat had
decreased by an average of nearly 4 lb and body weight by an average of less
than 2 lb in the individuals treated with MSH/ACTH"
-
For Severely
Obese Teens, Surgery, Stomach Bypass an Option When All Else Fails -
WebMD, 4/17/01
-
Eat
all you want and still lose pounds — someday - USA Today, 3/30/01
-
Moderate Exercise Better Than Hard-Core Workouts - Intelihealth, 3/28/01
-
"A new study suggests moderately paced, sustained
activities promote weight loss more effectively than brief, high-intensity
health club workouts"
-
Weight Loss
expert Jenny Craig - CNN, 3/15/01
-
New Fat-Loss
Drug Resets Brain's Weight Setpoint - WebMD, 3/20/01 -
"The drug, called Axokine, is a genetically
engineered version of a natural brain chemical, called CNTF, that makes new
brain cells grow ... [A] remarkable property that distinguishes ... A human
trial reported at a medical meeting last month showed that obese people who
got the most effective dose of Axokine lost nearly 10 pounds over 12 weeks
of treatment. Unlike previous weight loss drugs, these patients did not
immediately regain the weight -- in fact, they lost another pound during the
first six weeks they were off the drug, and they kept their lost weight off
for a minimum of six weeks after discontinuing the medication ... the drug
works a lot like
leptin ... Leptin would make a great weight loss
drug -- except that when a person becomes obese, he becomes resistant to it
the same way a diabetic person becomes resistant to insulin"
-
Virtual weight loss can be a reality - CNN, 3/6/01
-
Reducing the
Obesity Epidemic: What Works and What Doesn't, When Exercise, Diet, and
Pills Don't Work, Surgery May Be the Answer - WebMD, 3/1/01 -
"Millions of Americans suffer with life-threatening
obesity, and the only proven, effective treatment is surgery," Smith says.
"When faced with a life-threatening illness like heart disease, patients
readily accept major surgery -- including its risks -- as the necessary step
to treat their heart disease. The same is true for obesity."
-
Big
losers, and proud of it - USA Today, 2/15/01
-
Improving Dopamine May Help Obese - Doctor's Guide, 2/5/01
-
Elizabeth Cohen - CNN, 2/2/01 -
"What this new study seems to say is that obese
people don't have the normal amount of dopamine receptors in their brains"
-
USDA: Most Popular Diets Flawed - Intelihealth, 1/10/01
-
Cellulite-busting workout relies on weightlifting - CNN, 1/3/01
-
The Key to
Keeping the Pounds Off - WebMD, 12/12/00
-
Women gain weight at puberty, pregnancy, menopause - CNN, 11/1/00
-
Yo-Yo Dieting Is
a No-No, Study Shows the Ups and Downs May Harm the Heart - WebMD,
10/31/00
-
Stress is bad, but one expert says it's also fattening - CNN, 10/31/00
-
Spare Tire
Around the Middle? Maybe Your Life Is Too Hectic - WebMD, 10/24/00
-
Skill-Training
Method Works for Weight Loss, Study Finds - WebMD, 10/23/00
-
Health Focus: Five Tips For Losing Weight - Intelihealth, 8/30/00
-
Experts Find
Recipe for Weight Loss Success - WebMD, 8/23/00
-
Studies of CLA
Have Promising Results - WebMD, 8/20/00 -
"But it is important to look for credible brands of
CLA, cautions Pariza, whose team used a 'high
grade' version that was more than 90% pure: "There's a lot of junk out
there."
-
Researchers
Discover How Cells in the Body Get Fat - WebMD, 8/10/00
-
Study Links Diet
Pills to Greater Stroke Risk - WebMD, 7/28/00
-
Could Licorice
Help You Get Lean? - WebMD, 7/14/00
-
Flipping the
Appetite Switch Off - WebMD, 6/29/00
-
Over-the-Counter
Drug (phenylpropanolamine) Works to Suppress Appetite - WebMD, 5/29/00
-
Diet Shakes Can
Help People Control Their Weight - WebMD, 5/29/00
-
Fat-Soluble
Vitamin Absorption Not Threatened by Fat Cutbacks - WebMD, 5/19/00
-
Is Yo-Yo Dieting
a No-No for Women? - WebMD, 5/16/00
-
A rapid weight-loss diet may help shed fat in a flash - CNN, 4/13/00
-
Exercise Trains Fat Cells - Intelihealth, 4/7/00
-
Green Tea Could Promote Weight Loss - Nutrition Science News, 4/00
-
Diet, Exercise And Gain Weight? - Intelihealth, 4/3/00
-
Fiber May Help Prevent Obesity - Intelihealth, 10/27/99
-
Group Calls Low-Carb Diet Unhealthy - Intelihealth, 10/18/99
-
New hormone may help treat obesity - CNN, 8/30/99
- Exercise Affects Obesity
Independently Of Genes, Study Shows - Doctor's Guide, 6/1/99
- Bupropion SR Shows
Promise As Weight-Loss Treatment - Doctor's Guide, 5/20/99
-
Researchers
block hormone that affects eating - CNN, 12/21/98
- Study Confirms That
Chromium Picolinate Aids In Body Fat Loss - Doctor's Guide, 6/23/98
-
Study:
Americans fatter than ever and getting even fatter - CNN, 5/28/98
Abstracts:
-
Carnosic
acid as a major bioactive component in rosemary extract ameliorates high-fat
diet-induced obesity and metabolic syndrome in mice - J Agric Food Chem.
2015 Apr 30 - "The mice were given a low-fat diet, a high-fat diet or a high-fat
diet supplemented with either 0.14% or 0.28% (w/w) CA-enriched RE (containing
80% CA, RE#1L and RE#1H), or 0.5% (w/w) RE (containing 45% CA, RE#2), for a
period of 16 weeks ... The dietary RE supplementation significantly reduced body
weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver
weight, liver triglyceride and free fatty acid levels compared with the mice fed
with HF diet without RE treatment. RE administration also decreased the levels
of plasma and liver malondialdehyde, advanced glycation end products (AGEs) and
the liver expression of receptor for AGE (RAGE) compared with mice of HF group"
- See rosemary extract at Amazon.com.
-
Chlorogenic
acid and caffeine in combination inhibit fat accumulation by regulating hepatic
lipid metabolism-related enzymes in mice - Br J Nutr. 2014
Sep;112(6):1034-40 - "chlorogenic acid (CGA) ... forty
mice were randomly assigned to four groups and fed diets containing no CGA or
caffeine, CGA, caffeine, or CGA+caffeine for 24 weeks ... There was a decrease
in the body weight and IPAT weight of mice fed the CGA+caffeine diet. There was
a significant decrease in the serum and hepatic concentrations of total
cholesterol, TAG and leptin of mice fed the CGA+caffeine diet ... These results
indicate that CGA+caffeine suppresses fat accumulation and body weight gain by
regulating the activities and mRNA and protein expression levels of hepatic
lipid metabolism-related enzymes and that these effects are stronger than those
exerted by CGA and caffeine individually" - See
green coffee bean extract at Amazon.com.
-
Decaffeinated green coffee bean extract attenuates diet-induced obesity and
insulin resistance in mice - Evid Based Complement Alternat Med.
2014;2014:718379 - "decaffeinated green coffee bean
extract appeared to reverse HFD-induced fat accumulation and insulin resistance
by downregulating the genes involved in adipogenesis and inflammation in
visceral adipose tissue" - See
green coffee bean extract at Amazon.com.
-
Hypovitaminosis D and
incidence of obesity: a prospective study - Eur J Clin Nutr. 2013
Jun;67(6):680-2 - "In subjects who were non-obese (BMI
<30 kg/m(2)) at the second evaluation, 25-hydroxyvitamin D values 17 ng/ml (42.5
nmol/l) were significantly associated with an increased risk of developing
obesity in the next 4 years (OR=2.35, 95% CI: 1.03-5.4, P=0.040 after diverse
adjustments). We conclude that vitamin D deficiency is associated with an
increased risk of developing obesity" - See
vitamin D at Amazon.com.
-
Effect of
dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats
- Lipids Health Dis. 2013 Feb 4;12(1):8 - "the
accumulation of abdominal white adipose tissues was markedly prevented in
resveratrol diet-fed OLETF rats after 4 weeks of feeding ... Our study
demonstrated that dietary resveratrol can prevent obesity through a change in
the metabolic profile of nutrients in obese OLETF rats" - See
resveratrol products at Amazon.com.
-
Calcium plus
vitamin D3 supplementation facilitated Fat loss in overweight and obese college
students with very-low calcium consumption: a randomized controlled trial -
Nutr J. 2013 Jan 8;12(1):8 - "to receive either an
energy-restricted diet (-500 kcal/d) supplemented with 600 mg elemental calcium
and 125 IU vitamin D3 or energy restriction alone for 12 weeks. Repeated
measurements of variance were performed to evaluate the differences between
groups for changes in body weight, BMI, body composition ... A significantly
greater decrease in fat mass loss was observed in the calcium + D group
(-2.8+/-1.3 vs.-1.8+/-1.3 kg; P=0.02) than in the control group, although there
was no significant difference in body weight change (P>0.05) between groups. The
calcium + D group also exhibited greater decrease in visceral fat mass and
visceral fat area" - See
vitamin D at Amazon.com.
-
A 12-week
double-blind randomized clinical trial of vitamin D3 supplementation on body fat
mass in healthy overweight and obese women - Nutr J. 2012 Sep 22;11(1):78 -
"In a double-blind, randomized, placebo-controlled, parallel-group trial,
seventy-seven participants (age 38+/-8.1 years, BMI 29.8+/-4.1 kg/m2) were
randomly allocated into two groups: vitamin D (25 mug per day as
cholecalciferol) and placebo (25 mug per day as lactose) for 12 weeks ... Among
healthy overweight and obese women, increasing 25(OH) D concentrations by
vitamin D3 supplementation led to body fat mass reduction" - See
vitamin D at Amazon.com.
-
Beneficial
effects of catechin-rich green tea and inulin on the body composition of
overweight adults - Br J Nutr. 2011 Oct 28:1-6 -
"The aim of the present study was to investigate whether the effect of
catechin-rich green tea in combination with inulin affects body weight and fat
mass in obese and overweight adults. A total of thirty subjects were divided
into a control group and an experimental group who received 650 ml tea or
catechin-rich green tea plus inulin. A reduction of body weight ( - 1.29 (sem
0.35) kg) and fat mass (0.82 (sem 0.27) kg) in the experimental group was found
after 6 weeks, and no adverse effects were observed. After refraining from
consumption for 2 weeks, sustained effects on body weight and fat mass were
observed. We conclude that continuous intake of catechin-rich green tea in
combination with inulin for at least 3 weeks may be beneficial for weight
management" - Note: 1.29 kg is 2.8 pounds. See
inulin products at Amazon.com
and
green tea extract at Amazon.com.
-
Vitamin
A Decreases Pre-receptor Amplification of Glucocorticoids in Obesity: Study
on the Effect of Vitamin A on 11beta-Hydroxysteroid Dehydrogenase Type 1
Activity in Liver and Visceral Fat of WNIN/Ob Obese Rats - Nutr J. 2011
Jun 23;10(1):70 - "11beta-hydroxysteroid
dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of inactive
glucocorticoids to active glucocorticoids and its inhibition ameliorates
obesity and metabolic syndrome. So far, no studies have reported the effect
of dietary vitamin A on 11beta-HSD1 activity in visceral fat and liver under
normal and obese conditions. Here, we studied the effect of chronic feeding
of vitamin A-enriched diet (129mg/kg diet) on 11beta-HSD1 activity in liver
and visceral fat of WNIN/Ob lean and obese rats ... Control groups received
stock diet containing 2.6mg vitamin A/kg diet, where as experimental groups
received diet containing 129mg vitamin A/Kg diet for 20 weeks ... Vitamin A
supplementation significantly decreased body weight, visceral fat mass and
11beta-HSD1 activity in visceral fat of WNIN/Ob obese rats. Hepatic
11beta-HSD1 activity and gene expression were significantly reduced by
vitamin A supplementation in both the phenotypes. CCAAT/enhancer binding
protein alpha(C/EBPalpha), the main transcription factor essential for the
expression of 11beta-HSD1, decreased in liver by vitamin A fed-obese rats,
but not in lean rats. Liver X receptor alpha (LXR alpha), a nuclear
transcription factor which is known to downregulate 11beta-HSD1 gene
expression was significantly increased by vitamin A supplementation in both
the phenotypes" - Note: See my
11beta-HSD1 page. 11beta-HSD1 goes hand in hand with cortisol.
-
Dietary
supplementation of n-3 PUFA reduces weight gain and improves postprandial
lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat
- Diabetes Obes Metab. 2009 Nov 16 - "n-3 PUFA
treatment resulted in a significant improvement (i.e. decrease) in the
postprandial response for triglyceride (45%) (p < 0.05), apoB48 (45%) (p <
0.03) and LBP (33%) (p < 0.05) compared to controls (measured as area under
the clearance curve). In contrast, we observed a significant elevation in
postprandial haptoglobin (165%) (p < 0.001) in obese rats supplemented with
10% n-3 PUFA. Treatment with 5% n-3 PUFA in the JCR:LA-cp obese animals
resulted in a complementary decrease in total body weight gain (6%) (p <
0.001) and an increase (i.e. improvement) in adiponectin (33%) (p < 0.05)
compared to controls, without a concomitant reduction in food intake"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Effect of tea catechins on body fat accumulation in rats fed a normal diet
- Biomed Res. 2008 Feb;29(1):27-32 - "The
administration of 0.5% catechins decreased the accumulation of body fat and
the serum levels of cholesterol and bile acids. These results indicate that
tea catechins modulate lipid metabolism not only in obese subjects, but also
in the non-obese" - See
green tea extract at Amazon.com.
-
Can EGCG Reduce Abdominal Fat in Obese Subjects? - J Am Coll Nutr. 2007
Aug;26(4):396S-402S - "heart rate (HR) ... Moderate
consumption of EGCG
can improve the health status of overweight individuals undergoing regular
exercise by reducing HR and plasma glucose concentrations. Loss of body fat,
however, may require a higher intake of EGCG, other catechins or addition of
metabolic stimulants" - See
green tea extract at Amazon.com, my favorite is
green tea extract at Amazon.com.
-
The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation
in obese men: a pilot study - J Am Coll Nutr. 2007 Aug;26(4):389S-95S -
"These findings suggest that EGCG alone has the
potential to increase fat oxidation in men and may thereby contribute to the
anti-obesity effects of green tea" - See
green tea extract at Amazon.com, my favorite is
green tea extract at Amazon.com.
-
The influence of calcium consumption on weight and fat following 9 months of
exercise in men and women - J Am Coll Nutr. 2007 Aug;26(4):350-5 -
"Average calcium consumption was 987 +/- 389 mg/day
for men and 786 +/- 276 mg/day for women. Weight change over the 9 months
was -4.6 +/- 4.6 kg for men and 0.2 +/- 3.3 kg for women ... Weight and fat
weight loss as a result of nine months of moderate intensity exercise may be
improved by increased calcium consumption in men but was not observed in
women" - Note: 4.6 kg is 10.14 lbs.
-
Overweight Postmenopausal Women Lose Bone With Moderate Weight Reduction and
1 g/day Calcium Intake - J Bone Miner Res. 2005 Mar;20(3):455-63 -
"Despite an intake of 1 g Ca/day, bone loss occurred
at some sites because of weight loss. Calcium intake of 1.7 g/day will
minimize bone loss during weight loss in postmenopausal overweight women"
-
Effects of metformin on the body composition in subjects with risk
factors for type 2 diabetes - Diabetes Obes Metab. 2005
Mar;7(2):189-92 -
"In the metformin group, there was a decrease in
fat weight from 25.9 +/- 9.4 to 20.8 +/- 9.2 kg, p < 0.01, an increase
in lean weight from 57.05 +/- 13.6 to 61.9 +/- 16.5 kg, p < 0.01, an
increase in basal metabolism from 1735 +/- 413 to 1878 +/- 505
calories/day, p < 0.05 and an increase in body water" - See
metformin at IAS
or OffshoreRx1.com.
Note: That's a 19.7% decrease in fat (25.9-20.8)/25.9 = 19.7%, a 8.5%
increase in lean weight (61.9-57.05)/57.05 = 8.5% and a 8.2% increase in
basal metabolism (1878-1735)/1735 = 8.2%. - Ben
-
Ingestion of a tea rich in catechins leads to a reduction in body fat and
malondialdehyde-modified LDL in men - Am J Clin Nutr. 2005
Jan;81(1):122-9 -
"Body weight, BMI, waist circumference, body fat
mass, and subcutaneous fat area were significantly lower in the green tea
extract group than in the control group"
- See
green tea extract at Amazon.com.
-
Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic
Performance - JAMA, 3/26/03 -
"Ephedrine and ephedra
promote modest short-term weight loss (0.9 kg/mo more than placebo) in
clinical trials. There are no data regarding long-term weight loss, and
evidence to support use of ephedra for athletic performance is insufficient.
Use of ephedra or ephedrine and caffeine is associated with increased risk
of psychiatric, autonomic, or gastrointestinal symptoms, and heart
palpitations"
-
The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely
associated with changes in body weight and serum leptin in subjects with
type 2 diabetes mellitus - J Nutr. 2003 Jan;133(1):257S-260S
-
The effect of conjugated linoleic acid supplementation after weight loss on
body weight regain, body composition, and resting metabolic rate in
overweight subjects
- Int J Obes Relat Metab Disord. 2003 Jul;27(7):840-7 -
"As a consequence of an increased regain of fat-free
mass by
CLA, resting metabolic rate was increased by CLA (LD 12.0+/-11.4%, HD
13.7+/-14.4%) compared to placebo ... In conclusion, the regain of fat-free
mass was favorably, dose-independently affected by a 13-week consumption of
1.8 or 3.6 g CLA/day and consequently increased the resting metabolic rate.
However, it did not result in improved body weight maintenance after weight
loss" - See
conjugated linoleic acid at Amazon.com.
-
How much physical activity is enough to prevent unhealthy weight gain?
- Obes Rev 2003 May;4(2):101-14 - "The following
consensus statement was accepted unanimously. 'The current physical activity
guideline for adults of 30 minutes of moderate intensity activity daily,
preferably all days of the week, is of importance for limiting health risks
for a number of chronic diseases including coronary heart disease and
diabetes. However for preventing weight gain or regain this guideline is
likely to be insufficient for many individuals in the current environment.
There is compelling evidence that prevention of weight regain in formerly
obese individuals requires 60-90 minutes of moderate intensity activity or
lesser amounts of vigorous intensity activity. Although definitive data are
lacking, it seems likely that moderate intensity activity of approximately
45 to 60 minutes per day, or 1.7 PAL (Physical Activity Level) is required
to prevent the transition to overweight or obesity. For children, even more
activity time is recommended. A good approach for many individuals to obtain
the recommended level of physical activity is to reduce sedentary behaviour
by incorporating more incidental and leisure-time activity into the daily
routine"
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