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Home > Anti-aging Research > Gymnema Sylvestre

Gymnema Sylvestre

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  • First human trial backs GS diabetes benefits - Nutra USA, 7/22/10 - "Their findings recorded an average reduction in fasting blood glucose from 162 +/- 23 to 119 +/- 17 mg/dL. After eating, blood glucose levels were found to have reduced from 291 +/-10 to 236 +/-30 mg/dL"


  • A novel Gymnema sylvestre extract protects pancreatic beta-cells from cytokine-induced apoptosis - Phytother Res. 2019 Sep 12 - "Inflammatory cytokines such as interleukin-1β, TNF-α, and interferon-γ are known to be involved in mediating β-cells death in diabetes mellitus (DM). Thus, protecting from β-cells death in patients with DM may be a useful target in alleviating symptoms of hyperglycemia. Traditional plant-based remedies have been used to treat DM for many centuries and may play a role in protecting β-cell from death. An example of these remedies is Gymnema sylvestre (GS) extract ... Om Santal Adivasi (OSA®) maintained cell membrane integrity in MIN6 cells and mouse islets. Om Santal Adivasi significantly protected MIN6 cells and mouse islets from cytokine-induced apoptosis. In the presence of cytokines, OSA® significantly reduced the expression and activity of caspase-3. The antiapoptotic effect of OSA® as shown by microarray analysis is largely mediated by activating pathways involved in cell survival (mainly casein kinase II pathway) and the free radical scavenger system (specifically superoxide dismutase and catalase). This study indicates that the GS isolate OSA® protects against cytokine-induced apoptosis of β-cells by increasing the expression of cell survival pathways and free radical scavenger system" - See Gymnema sylvestre at Amazon.com.
  • There’s some science behind claims that gymnema can curb sugar cravings - Washington Post, 5/21/18 - "I don’t think gymnema is going to solve our more deep-seated issues around sugar. But it might be helpful in temporarily riding out food cravings — which are known to come on strong at first but fade after a little time. Regardless of whether you try it, consider adopting long-term changes toward making such cravings a thing of the past"
  • Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice - J Asian Nat Prod Res 2000;2(4):321-7 - "These results indicate that insulin-releasing action of gymnemic acid IV may contribute to the antihyperglycemic effect by the leaves of G. sylvestre. Gymnemic acid IV may be an anti-obese and antihyperglycemic pro-drug"