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Anti-aging Research > Chitosan
Chitosan
Specific Products:
News & Research:
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Study support Stratum’s chitin-glucan for weight management - Nutra USA,
4/13/11
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First evidence that chitosan could repair spinal damage - Science Daily,
4/16/10 - "Cho was amazed to see that the spinal
cord was completely dark. None of the dye had entered the nerve cells.
Chitosan had repaired the damaged cell membranes ... Next Cho tested whether
a dose of chitosan could prevent large molecules from leaking from damaged
spinal cord cells. Testing for the presence of the colossal enzyme lactate
dehydrogenase (LDH), Borgens admits he was amazed to see that levels of LDH
leakage from chitosan treated spinal cord were lower than from undamaged
spinal cords. Not only had the sugar repaired membranes at the compression
site but also at other sites where the cell membranes were broken due to
handling. And when the duo tested for the presence of harmful reactive
oxygen species (ROS), released when ATP generating mitochondria are damaged,
they found that ROS levels also fell after applying chitosan to the damaged
tissue: chitosan probably repairs mitochondrial membranes as well as the
nerve cell membranes"
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Edible Coating Makes Fish Fillets Longer-lasting, Healthier - Science
Daily, 7/16/09
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Chewing Chitosan-Loaded Gum Reduces Phosphate Levels in ESRD Patients -
Medscape, 2/16/09 - "Chewing chitosan-loaded gum
twice daily can significantly decrease salivary phosphate and serum
phosphate levels in hemodialysis patients and may help improve treatment for
hyperphosphatemia ... At week 1, the patients’ salivary phosphate levels had
decreased from 73.21 to 52.02 mg/dL (P < .01), and serum levels decreased
from 7.60 to 5.38 mg/dL (P < .00001). After 2 weeks, salivary phosphate
levels were reduced to 33.19 mg/dL (P < .00001) and serum levels decreased
to 5.25 mg/dL" - See
chitosan products at iHerb.
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Chitin From Lobster Shell Shows Great Healing And Bio-stimulant Properties
- Science Daily, 7/13/07
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Science building for chitosan weight management benefits - Nutra USA,
4/4/07
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Study Probes Weight Loss Supplement Chitosan - WebMD, 8/25/05
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Little evidence to support weight loss effect of all chitosan supplements
- Nutra USA, 8/24/05 - "Bjarte Langhelle, marketing
director of Primex, which sells the LipoSan brand chitosan, agreed that
there are a lot of “not so good trials out there” ... Langhelle believes
that numerous chitosans on the market are totally insoluble, making them
ineffective"
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Chitosan fails to reduce kilos, finds study - Nutra USA, 8/24/04 -
"receive either 3g of chitosan daily or a placebo
for 24 weeks ... The chitosan group lost an average of 0.4kg compared to a
0.2 kg gain in the placebo group"
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Chitosan: The Next Weight-loss Agent? - Nutrition Science News, 10/01 -
"in a more recent study, researchers found a specific brand of chitosan
(Chitosol) produces significantly greater weight loss than placebo ...
Although it is unclear whether chitosan helps with weight loss, it is clear
that all chitosan products are not equal"
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Shell Game - washingtonpost.com, 3/28/00
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Lowly shrimp shells could yield jumbo benefits, researchers say - CNN,
2/4/99
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Why
Americans Are So Fat - Life Extension Magazine, 11/97
Abstracts:
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Single-blind, placebo controlled randomised clinical study of chitosan for body
weight reduction - Nutr J. 2016 Jan 8;15(1):3 - [Nutra
USA] - "A phase IV, randomised,
multicentre, single-blind, placebo-controlled, clinical study was conducted by
administering chitosan capsules (500 mg, five/day) and indistinguishable placebo
capsules as daily supplements to 96 overweight and obese subjects for 90 days
... The mean changes in body weight were -1.78 ± 1.37 kg and -3.10 ± 1.95 kg at
day 45 and day 90 respectively in chitosan group which were significantly
different (p < 0.0001) as compared to placebo. BMI was decreased by10.91 fold
compared to placebo after 90 day administration. In concert with this, there was
also reduction in body composition and anthropometric parameters together with
improvement in QoL score. Chitosan was also able to reduce HbA1C levels (below 6
%) in subjects who had initial higher values. The mean caloric intake shows that
there was no change in dietary habits of subjects in both groups" -
Note: 3.1 kilograms is 6.8 pounds. See chitosan products at Amazon.com
 .
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Anti-obesity effects of chitosan and psyllium husk with L-ascorbic Acid in
Guinea pigs - Int J Vitam Nutr Res. 2012 Apr;82(2):113-20 -
"We found that the addition of L-Ascorbic acid to
chitosan influenced the reduction in body weight gain and FER, and the
increase in total fecal weight and fecal fat excretion in guinea pigs fed a
high-fat diet"
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A
Meta-Analysis Evaluating the Impact of Chitosan on Serum Lipids in
Hypercholesterolemic Patients - Ann Nutr Metab. 2009 Nov
13;55(4):368-374 - "Six studies (n = 416 patients)
met the inclusion criteria. Upon meta-analysis, the use of chitosan
significantly lowered total cholesterol [WMD, -11.59 mg/dl (-21.45 to
-1.73), p = 0.02] but not LDL cholesterol, HDL cholesterol or triglycerides"
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Evaluating efficacy of a chitosan product using a double-blinded,
placebo-controlled protocol - J Am Coll Nutr. 2006 Oct;25(5):389-94 -
"Compared to CTL, the TRT group lost more weight
(-2.8 lbs vs. +0.8 lbs, p < 0.001) and fat mass (-2.6 lbs vs. +0.1 lbs, p =
0.006). Compared to PLA, the TRT group lost more weight (-2.8 lbs. vs. -0.6
lbs, p = 0.03), % fat (-0.8% vs. +0.4%, p = 0.003), fat mass (-2.6 lbs vs.
+0.6 lbs, p = 0.001) and had a greater body composition improvement index
(BCI) (+2.4 lbs vs. -1.9 lbs, p = 0.002)"
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Effect of chitosan on weight loss in overweight and obese individuals: a
systematic review of randomized controlled trials
- Obes Rev. 2005 Feb;6(1):35-42
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Chitosan decreases total cholesterol in women: a randomized, double-blind,
placebo-controlled trial - Eur J Clin Nutr 2003 May;57(5):721-5 -
"assigned to receive chitosan (1.2 g per day) or placebo ... Chitosan
significantly (F=3.19, P=0.04) reduced total
cholesterol compared to placebo. In a subgroup of subjects with over 60
y of age, chitosan group significantly reduced total and LDL cholesterol"
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Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the
apolipoprotein E-deficient mouse model of atherosclerosis -
Atherosclerosis. 1998 Jun;138(2):329-34
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Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal
streptozotocin-induced diabetic mice - Biol Pharm Bull. 1995
Nov;18(11):1623-5
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Interrelated effects of dietary fiber and fat on lymphatic cholesterol and
triglyceride absorption in rats - J Nutr. 1989 Oct;119(10):1383-7
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Interaction of bile acids, phospholipids, cholesterol and triglyceride with
dietary fibers in the small intestine of rats - J Nutr. 1989
Aug;119(8):1100-6
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