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Xenical (orlistat)

Where to purchase:

• Alli at Amazon.com

Related Topics:

• Axokine / leptin / obesity / weight control / ghrelin / peripheral hormone peptide YY (PYY 3-36) / PGC-1beta / oleylethanolamide (OEA) / Xenical (orlistat) / Meridia® (sibutramine) / Topamax® (topiramate) / Wellbutrin®/Zyban® (bupropion) / Glucophage (metformin) / Acomplia (rimonabant)

News & Research:

• Most Popular Weight-Loss Drug Strongly Alters Other Drug Therapies, Study Suggests - Science Daily, 12/10/12 - "the weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to "severe toxicity of internal organs such as the liver and kidney." The inhibition is irreversible ... also found that the drug alters efficacy of medicines, and particularly limits the effectiveness of some anti-cancer drugs ... It has been linked to severe liver failure, acute pancreatic failure and acute renal (kidney) failure ... It is generally accepted that orlistat remains in the intestine and that the body does not absorb it ... But orlistat is reportedly absorbed, and certainly internal organs such as the liver and kidney are exposed to this drug upon absorption"
• Popular diet drug gets liver damage warning - MSNBC, 5/26/10
• Significant Visceral Fat Loss Seen Within 12 Weeks With Orlistat - Medscape, 2/3/10
• Fatty Liver Disease Medication May Have No Effect - Science Daily, 1/13/09
• Does Orlistat, OTC Diet Pill Alli, Live Up To Its Name? - Science Daily, 6/12/07 - "people taking orlistat and following low-fat diets lost almost five percent of their initial body weight, about seven to15 pounds, over four months" - See Alli at Amazon.com.RxList search of orlistat.
• Are there any drug interactions between Xenical and other therapies? - Drugstore.com
• Orlistat Potentiates Weight Loss Without Affecting Eating Behaviour - Doctor's Guide, 4/24/07
• Lowdown on OTC Weight-Loss Drug - washingtonpost.com, 2/20/07
• Over-the-Counter Weight Loss Pill OK'd - WebMD, 2/7/07 - "FDA approved orlistat capsules -- called "alli" -- as an over-the-counter weight loss aid for overweight adults ... the pill will be available in U.S. stores by this summer"
• FDA Joint Advisory Committee Recommends Approval of Orlistat 60 mg Capsules for Over-the-Counter Use - Doctor's Guide, 1/24/06 - "the U.S. Food and Drug Administration's (FDA) joint Nonprescription Drugs and Endocrinologic and Metabolic Drugs Advisory Committee voted 11 to 3 to recommend approval of orlistat 60 mg capsules for over-the-counter (OTC) use in the United States"
• University of Kentucky Doctor Presents Findings Regarding New Weight-Loss Medication - Doctor's Guide, 10/19/05
• FDA Approves Labeling Showing Xenical (Orlistat) Treatment Resulted in 42% Reduction in Relative Risk of Developing Type 2 Diabetes - Doctor's Guide, 10/29/04
• Diabetic People Benefit From Weight Loss Drug - WebMD, 4/6/04
• Anti-Obesity Drug May Slow Cancer Growth - WebMD, 3/17/04
• Weight Loss with Xenical (Orlistat) Reduces Threat of Developing Type 2 Diabetes - Doctor's Guide, 12/23/03
• FDA Approves Labeling for Use of Xenical (Orlistat) in Management of Obesity in Adolescents - Doctor's Guide, 12/16/03
• Modest Effects On Weight Loss Seen With Orlistat And Sibutramine - Doctor's Guide, 9/30/03
• Orlistat Reduces Type 2 Diabetes in High-Risk Obese Patients - Doctor's Guide, 6/16/03
• Orlistat Keeps The Weight Off Over Three Years In Metabolic Syndrome Patients - Doctor's Guide, 6/3/03 - See online prescriptions.
• Orlistat Plus Low Calorie Diet Enhances Weight Loss - Doctor's Guide, 4/23/03
• Overweight Diabetics Benefit Significantly From Orlistat - Doctor's Guide, 2/4/03
• Orlistat Lowers Blood Pressure In Obese People With Inadequately Controlled Hypertension - Doctor's Guide, 11/12/02
• Orlistat Helps Control Blood Sugar in Type 2 Diabetes - Doctor's Guide, 9/2/02
• Orlistat Shown to Cut Diabetes Risk - Doctor's Guide, 8/27/02
• Landmark XENDOS Study Shows Xenical (Orlistat) Significantly Prevents Or Delays The Development Of Type 2 Diabetes - Doctor's Guide, 8/26/02
• Diet Drug [Xenical] Keeps Diabetes at Bay - WebMD, 8/25/02
• Orlistat Helpful for Obese Type 2 Diabetics - Medscape, 6/27/02
• Orlistat Found Beneficial in Type 2 Diabetics with Differing Hemoglobin A1c Levels - Doctor's Guide, 6/19/02
• Xenical (Orlistat) Helps Maximally-Medicated Diabetics Avoid Insulin - Doctor's Guide, 6/17/02
• Xenical (Orlistat) Improves Post-prandial Glucose Levels in Obese Diabetics - Doctor's Guide, 6/16/02
• New Data Confirm Rapid And Sustained Weight Loss With Xenical (Orlistat) 4kg Loss In First Month Rising To 11.6kg After One Year - Doctor's Guide, 5/28/02
• The Skinny on Fat Drugs - WebMD, 2/20/02 - "The weight loss drug that keeps the gut from absorbing fat is called Xenical. It makes a person excrete about a third of all dietary fat in the stool. It also makes a person excrete fat-soluble vitamins, especially vitamin D"
• Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity - Blackwell-Synergy.com, 1/02 - "sibutramine, orlistat and metformin are all effective and safe medications that reduce cardiovascular risk and can decrease the risk of type 2 diabetes mellitus in obese females. Overall, treatment with 10mg sibutramine bid is more effective than orlistat or metformin therapy in terms of weight reduction"
• Good News About Weight-Loss Drug Xenical - WebMD, 10/12/01
• Xenical (Orlistat) Produces Rapid/Sustained Weight Loss - Doctor's Guide, 10/9/01
• Xenical Drops Weight, Blood Sugar in Diabetics - WebMD, 9/12/01
• Xenical (Orlistat) Improves Glycaemic Control in Overweight Type 2 Diabetics - Doctor's Guide, 9/10/01
• Pilot Study Of The Use Of Orlistat (Xenical) In Obese Children - Doctor's Guide, 7/9/01
• Orlistat (Xenical) Benefits Overweight Diabetics Receiving Insulin Therapy - Doctor's Guide, 6/24/01
• Orlistat (Xenical) Shown Effective in Obese Patients in Community Practices - Doctor's Guide, 6/4/01
• Orlistat (Xenical) Plus Reduced Calorie Diet Beneficial For Obese Non-Diabetics - Doctor's Guide, 5/31/01
• National Institute for Clinical Excellence Supports Xenical (Orlistat) For Weight Loss - Doctor's Guide, 3/12/01
• Xenical (Orlistat) May Help Reduce Heart Disease Risk In People With Type 2 Diabetes - Doctor's Guide, 11/13/00
• Xenical (Orlistat) Can Also Help Lower Blood Pressure in Obese Hypertensives - Doctor's Guide,  11/13/00
• Xenical (Orlistat) Significantly Reduces Weight Among Type 2 Diabetics, Improves Sugar Control - Doctor's Guide, 11/7/00
• Researchers Find That Weight-Loss Drug, Orlistat, Blocks Cholesterol Absorption - Doctor's Guide, 11/1/00
• Xenical (Orlistat) Improves Cholesterol Profile Independent Of Total Weight Loss - Doctor's Guide, 5/24/00
• Fat-Blocking Drug Xenical (Orlistat) May Prevent Some Type 2 Diabetes - Doctor's Guide, 5/8/00
• Xenical Safe And Effective For Long-Term Weight Loss - Doctor's Guide, 11/17/99
• Xenical Effective For Weight Loss Among Elderly Obese - Doctor's Guide, 11/15/99
• Orlistat Offers Double Benefits To Obese Diabetics - Doctor's Guide, 9/29/99
• Xenical Plays Important Role In Cardiovascular Risk Reduction - Doctor's Guide, 8/31/99
• Orlistat: It Isn't Worth The Trouble - Ask Dr. Dean, 7/14/99
• Untested diet drug combination concerns researchers - CNN, 5/19/99
• Weight-Loss Drug Xenical Approved In U.S. For Treatment Of Obesity - Doctor's Guide, 4/26/99
• Health benefits of weight-loss drug disputed - CNN, 1/20/99
• Xenical Promotes Weight Loss, Helps Keep It Off For Two Years, Study Shows - Doctor's Guide, 1/19/99
• Data Show Xenical Improves Glucose And Lipid Levels In Diabetics - Doctor's Guide, 8/3/98
• FDA delays approval of new diet drug amid cancer concern - CNN, 5/13/98
• FDA panel divided over new diet drug - CNN, 3/13/98
• Xenical May Have Role In Long-Term Management of Obesity - Doctor's Guide, 11/11/97
• Xenical Twice As Effective As Diet Alone - Doctor's Guide, 6/19/97

Abstracts:

• Prevention of Type 2 diabetes: fact or fiction? - Expert Opin Pharmacother. 2007 Dec;8(18):3147-58 - "The XENDOS (Xenical in the Prevention of Diabetes in Obese Subjects) study examined the use of orlistat, an antiobesity drug, as an adjunct to an intensive lifestyle modification program in obese non-diabetic subjects. Orlistat treatment resulted in a 37% decline in the development of diabetes"