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Axokine

Related Topics:

• Axokine / leptin / obesity / weight control / ghrelin / peripheral hormone peptide YY (PYY 3-36) / PGC-1beta / oleylethanolamide (OEA) / Xenical (orlistat) / Meridia® (sibutramine) / Topamax® (topiramate) / Wellbutrin®/Zyban® (bupropion) / Glucophage (metformin) / Acomplia (rimonabant)

News & Research:

• New Weight Loss Drug Works in Diabetes - WebMD, 10/16/03 - "After 12 weeks, people taking Axokine had about a 7-pound drop in weight compared with about a 2-pound weight loss in the placebo group"
• Axokine Promotes Weight Loss in Overweight, Obese Patients With Type 2 Diabetes - Medscape, 10/13/03
• New Weight-Loss Drugs Pass First Tests - WebMD, 4/8/03 - "Axokine is a brand new drug with hopes of being a totally different kind of weight-loss drug ... The drug affects a powerful brain system called the leptin pathway. Leptin is a chemical messenger that tells you when you've had enough to eat. Obese people have leptin resistance; they lose the ability to know when they're full. Axokine apparently bypasses this resistance and flips the fullness switch"
• New Fat-Loss Drug Resets Brain's Weight Setpoint - WebMD, 3/20/01 - "The drug, called Axokine, is a genetically engineered version of a natural brain chemical, called CNTF, that makes new brain cells grow ... [A] remarkable property that distinguishes ... A human trial reported at a medical meeting last month showed that obese people who got the most effective dose of Axokine lost nearly 10 pounds over 12 weeks of treatment. Unlike previous weight loss drugs, these patients did not immediately regain the weight -- in fact, they lost another pound during the first six weeks they were off the drug, and they kept their lost weight off for a minimum of six weeks after discontinuing the medication ... the drug works a lot like leptin ... Leptin would make a great weight loss drug -- except that when a person becomes obese, he becomes resistant to it the same way a diabetic person becomes resistant to insulin"
• AXOKINE, Regeneron clinical data - R&D Focus Drug News, 12/11/00