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Home > Anti-aging Research > Leptin

Leptin

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  • Protective Effects of Melatonin against Obesity-Induced by Leptin Resistance - Behav Brain Res 2021 Sep 23 - "Leptin resistance is due to excess leptin, a saturation of its transporters, and deficiency in either the receptor level or signalling in the hypothalamus. Leptin resistance leads to obesity due to excess food intake and less energy expenditure. Normal leptin secretion follows a rhythm, and alteration in the lifestyle leads to hormonal imbalances and increases ROS generation leading to oxidative stress. The sleep disturbance causes obesity with increased lipid accumulation in adipose tissue. Melatonin is the master regulator of the sleep-wake cycle secreted by the pineal gland during the night. It is a potent antioxidant with anti-inflammatory properties. Melatonin is secreted in a pattern called the circadian rhythm in humans as well. Research indicates that melatonin plays a vital role in hormonal regulation and energy metabolism, including leptin signalling and secretion" - See melatonin at Amazon.com and iHerb.
  • Effects of Supplementation with Curcumin on Serum Adipokine Concentrations: A Randomized Controlled Trial - Nutrition, Mar 2016 - "randomly assigned to curcumin (n=59; 1000 mg/day) or placebo (n=58) for 8 weeks ... Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (p<0.001), and a reduction in serum leptin concentrations (p<0.001). Serum leptin:adiponectin ratio was also improved by curcumin (p<0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations, and baseline differences in BMI and serum levels of glucose and HbA1c as potential confounders of treatment response. Meta-analysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14, 147.42; p=0.0330), and reduce leptin by 26.49%" - [Nutra USA] - See curcumin products at Amazon.com.
  • A Hormone to Promote Weight Loss? - Dr. Weil, 5/27/05
  • Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats - Br J Nutr. 2009 Mar 19:1-13 - "Conjugated linoleic acid (CLA) isomers have been reported to reduce body weight and beneficially affect glucose metabolism in animals, but the results are inconsistent and seem to depend on animal model and type of CLA isomer. In the present study, feeding male Zucker fa/fa rats diets supplemented with 1 % trans-10, cis-12-CLA for 10 d reduced the liver TAG content without improving the overall adiposity, and enhanced hepatic mitochondrial and peroxisomal beta-oxidation ... The present results suggest that dietary supplementation with trans-10, cis-12-CLA may increase the catabolism of lipids in liver and adipose tissue. Moreover, we provide new data suggesting that trans-10, cis-12-CLA modulates the expression of resistin and adiponectin inversely in adipose tissue. Hence, the present results suggest that trans-10, cis-12-CLA may have some beneficial effects on lipid metabolism and adiposity but possibly reduces insulin sensitivity" - See conjugated linoleic acid at Amazon.com.
  • Conjugated Linoleic Acid Supplementation Enhances Antihypertensive Effect of Ramipril in Chinese Patients With Obesity-Related Hypertension - Am J Hypertens. 2009 Mar 19 - "Participants were randomized to a daily dose of 4.5 g/day CLA (nine 0.5-g capsules; a 50:50 isomer blend of c 9,t 11 and t 10,c 12 CLA) with 37.5 mg/day ramipril (group 1) or placebo with 37.5 mg/day ramipril (group 2) for 8 weeks ... Treatment with CLA significantly enhanced the reduction effect of ramipril on systolic BP and diastolic BP (P < 0.05). It also increased plasma adiponectin concentration (P < 0.05) and decreased plasma concentrations of leptin and angiotensinogen (P < 0.05); however, significant change was not observed in ACE activity" - See conjugated linoleic acid at Amazon.com.
  • New Zinc Research Reveals More Applications - Nutrition Science News, 7/01 - "Leptin, a hormone that regulates appetite, causes satiety. In developed countries, a high percentage of calories comes from table sugar, or sucrose. Animal experiments find that sucrose increases circulating levels of insulin, decreases leptin, and causes obesity. However, rats given zinc supplements with sugar showed normal leptin levels"
  • Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels - Endocrinology 1999 Feb;140(2):1009-12

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