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Alternative News:

• Protective Effects of Melatonin against Obesity-Induced by Leptin Resistance - Behav Brain Res 2021 Sep 23 - "Leptin resistance is due to excess leptin, a saturation of its transporters, and deficiency in either the receptor level or signalling in the hypothalamus. Leptin resistance leads to obesity due to excess food intake and less energy expenditure. Normal leptin secretion follows a rhythm, and alteration in the lifestyle leads to hormonal imbalances and increases ROS generation leading to oxidative stress. The sleep disturbance causes obesity with increased lipid accumulation in adipose tissue. Melatonin is the master regulator of the sleep-wake cycle secreted by the pineal gland during the night. It is a potent antioxidant with anti-inflammatory properties. Melatonin is secreted in a pattern called the circadian rhythm in humans as well. Research indicates that melatonin plays a vital role in hormonal regulation and energy metabolism, including leptin signalling and secretion" - See melatonin at Amazon.com and iHerb.
• Effects of Supplementation with Curcumin on Serum Adipokine Concentrations: A Randomized Controlled Trial - Nutrition, Mar 2016 - "randomly assigned to curcumin (n=59; 1000 mg/day) or placebo (n=58) for 8 weeks ... Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (p<0.001), and a reduction in serum leptin concentrations (p<0.001). Serum leptin:adiponectin ratio was also improved by curcumin (p<0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations, and baseline differences in BMI and serum levels of glucose and HbA1c as potential confounders of treatment response. Meta-analysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14, 147.42; p=0.0330), and reduce leptin by 26.49%" - [Nutra USA] - See curcumin products at Amazon.com.
• A Hormone to Promote Weight Loss? - Dr. Weil, 5/27/05
• Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats - Br J Nutr. 2009 Mar 19:1-13 - "Conjugated linoleic acid (CLA) isomers have been reported to reduce body weight and beneficially affect glucose metabolism in animals, but the results are inconsistent and seem to depend on animal model and type of CLA isomer. In the present study, feeding male Zucker fa/fa rats diets supplemented with 1 % trans-10, cis-12-CLA for 10 d reduced the liver TAG content without improving the overall adiposity, and enhanced hepatic mitochondrial and peroxisomal beta-oxidation ... The present results suggest that dietary supplementation with trans-10, cis-12-CLA may increase the catabolism of lipids in liver and adipose tissue. Moreover, we provide new data suggesting that trans-10, cis-12-CLA modulates the expression of resistin and adiponectin inversely in adipose tissue. Hence, the present results suggest that trans-10, cis-12-CLA may have some beneficial effects on lipid metabolism and adiposity but possibly reduces insulin sensitivity" - See conjugated linoleic acid at Amazon.com.
• Conjugated Linoleic Acid Supplementation Enhances Antihypertensive Effect of Ramipril in Chinese Patients With Obesity-Related Hypertension - Am J Hypertens. 2009 Mar 19 - "Participants were randomized to a daily dose of 4.5 g/day CLA (nine 0.5-g capsules; a 50:50 isomer blend of c 9,t 11 and t 10,c 12 CLA) with 37.5 mg/day ramipril (group 1) or placebo with 37.5 mg/day ramipril (group 2) for 8 weeks ... Treatment with CLA significantly enhanced the reduction effect of ramipril on systolic BP and diastolic BP (P < 0.05). It also increased plasma adiponectin concentration (P < 0.05) and decreased plasma concentrations of leptin and angiotensinogen (P < 0.05); however, significant change was not observed in ACE activity" - See conjugated linoleic acid at Amazon.com.
• New Zinc Research Reveals More Applications - Nutrition Science News, 7/01 - "Leptin, a hormone that regulates appetite, causes satiety. In developed countries, a high percentage of calories comes from table sugar, or sucrose. Animal experiments find that sucrose increases circulating levels of insulin, decreases leptin, and causes obesity. However, rats given zinc supplements with sugar showed normal leptin levels"
• Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels - Endocrinology 1999 Feb;140(2):1009-12

Other News:

• Serum leptin is associated with increased pulse pressure and the development of arterial stiffening in adult men: results of an eight-year follow-up study - Hypertens Res 2021 Aug 12 - "Those who had baseline leptin levels above the median had a greater risk of developing arterial stiffening (odds ratio: 2.5, p < 0.05) and a greater increase in pulse pressure over time (beta: 2.1, p < 0.05), also after adjustment for confounders. The results of this prospective study indicate a predictive role of circulating leptin levels for vascular damage, independent of body weight and blood pressure"
• Higher leptin is associated with hypertension: the Multi-Ethnic Study of Atherosclerosis - J Hum Hypertens. 2013 Mar 28 - "After adjustment for risk factors, a 1-s.d.-increment higher leptin level was significantly associated with higher systolic (5.0 mm Hg), diastolic (1.9), mean arterial (2.8) and pulse pressures (3.6), as well as a 34% higher odds for being hypertensive (P<0.01 for all)"
• Positive Relationship Between Plasma Leptin Level and Hypertension - Hypertension. 2010 Aug 16 - "We found that higher plasma leptin levels were positively associated with hypertension after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, diabetes mellitus, serum cholesterol, and C-reactive protein. Compared with quartile 1 of leptin (referent), the odds ratio (95% CI) of hypertension associated with quartile 4 was 1.89 (1.24 to 2.09; P for trend=0.0036). Subgroup analyses examining the relation between leptin and hypertension by sex and body mass index categories also showed a consistent positive association. In conclusion, higher plasma leptin levels are associated with hypertension both among women as well as men in a representative sample of US adults"
• Fat Hormone Leptin May Control Diabetes - WebMD, 1/5/10
• More Leptin May Mean Less Alzheimer's - WebMD, 12/15/09
• Fat Hormone Linked to Psoriasis - WebMD, 12/15/08 - "People with psoriasis may face a higher risk of obesity, metabolic syndrome, and other heart disease risk factors thanks to high levels of the so-called fat hormone leptin"
• Fructose -- Found In High-fructose Corn Syrup, Sugar -- Sets Table For Weight Gain Without Warning - Science Daily, 10/16/08 - "Eating too much fructose can induce leptin resistance, a condition that can easily lead to becoming overweight when combined with a high-fat, high-calorie diet"
• Terminally Ill Rodents With Type 1 Diabetes Restored To Full Health With Single Dose Of Leptin - Science Daily, 8/25/08
• Adiponectin, but not leptin or high-sensitivity C-reactive protein, is associated with blood pressure independently of general and abdominal adiposity - Hypertens Res. 2008 Apr;31(4):633-40 - "all three markers were significantly correlated with systolic blood pressure (negative correlation for adiponectin and positive correlations for leptin and hs-CRP)"
• Combining Exercise With Hormone Could Prevent Weight Gain - Science Daily, 5/27/08
• Hormone Leptin Tweaks Hungry Brain - WebMD, 10/29/07
• Fat hormone 'boosts colon cancer' - BBC News, 4/7/07
• Leptin Has Powerful Effect On Reward Center In The Brain - Science Daily, 9/29/06
• New Key Brain Target Of Fat Hormone - Science Daily, 1/26/06
• Fat Hormone May Counter Depression - WebMD, 1/17/06
• Fat Hormone Tied to Multiple Sclerosis - WebMD, 1/12/06
• Hunger hormone linked to memory - BBC News, 7/18/05
• Leptin Levels Associated with Cardiovascular Risk Factors - Doctor's Guide, 4/27/05
• Single Hormone Appears To Regulate Blood Sugar In Two Different Ways; Finding May Help Explain Why Not All Obese People Get Diabetes - Science Daily, 3/24/05
• Leptin: How Diabetes and Obesity Are Linked - mercola.com, 3/16/05
• Fat Hormone Acts On Brain Circuit To Curb Obesity, Diabetes - Science Daily, 1/27/05
• Sleep More and You May Control Eating More - WebMD, 11/9/04
• Appetite Hormone Restores Fertility - Science Daily, 9/24/04
• Fat Hormone May Improve Women's Health - WebMD, 9/1/04
• Winning The Battle Of The Bulge: We're A Scrimmage Closer To Victory - Science Daily, 4/29/04 - "High triglycerides are blocking the leptin from getting into the brain. If leptin can't get into the brain, it can't tell you to stop eating ... If you lower triglycerides, you should theoretically help the body's own leptin to work better so people can get skinnier"
• Another Fat Hormone May Aid in Weight Loss - WebMD, 4/23/04
• Fat Hormone Leptin Alters Brain Architecture And Activity, Which In Turn Drives Feeding Behavior - Science Daily, 4/2/04
• Leptin Level Predicts Outcome in Coronary Atherosclerosis - Doctor's Guide, 3/8/04
• Leptin Turns Fat Cells Into Fat-Burning Cells - WebMD, 2/9/04
• Blood Test Identifies Poor Dieters - Physician's Weekly, 1/26/04 - "patients with higher levels of leptin and insulin in their blood were less likely to consistently maintain weight loss programs"
• Curing Resistance to Fat Hormone Sheds Pounds - WebMD, 1/16/04
• Leptin Effects Bone Density Independent of Hormone Replacement Therapy - Doctor's Guide, 12/9/03
• Alcohol May Increase Breast Cancer Risk - WebMD, 11/18/03 - "Consuming one or two alcoholic drinks per day was found to increase blood levels of the fat hormone leptin"
• Leptin May Not Cure Obesity After All - Doctor's Guide, 11/12/03
• Obesity Hormone May Affect Osteoarthritis - WebMD, 11/4/03
• Higher Leptin Levels Detected in Patients with Rheumatoid Arthritis - Doctor's Guide, 9/26/03
• Hormone May Reverse Heart Damage - Physician's Weekly, 9/15/03
• New Weight-Loss Drugs Pass First Tests - WebMD, 4/8/03 - "Axokine is a brand new drug with hopes of being a totally different kind of weight-loss drug ... The drug affects a powerful brain system called the leptin pathway. Leptin is a chemical messenger that tells you when you've had enough to eat. Obese people have leptin resistance; they lose the ability to know when they're full. Axokine apparently bypasses this resistance and flips the fullness switch"
• The Great Weight Debate - WebMD, 2/6/03 - "A key element is the hormone leptin, which is produced by stored fat, he writes ... It's a vicious cycle. When we have less body fat, we have decreased leptin levels, which make us want to eat more -- yet reduces the amount of calories burnt"
• Feed a Cold, Starve MS - WebMD, 1/16/03
• Reduced Blood Pressure Correlated With Leptin After Weight Loss In Hypertensive Patients - Doctor's Guide, 1/6/03
• Leptin Strongly Positively Associated With Endometrial Cancer - Doctor's Guide, 8/29/02
• Factors Influencing Leptin Receptor Expression - Doctor's Guide, 7/11/02
• Leptin and Soluble Leptin Receptor Levels in Obese and Weight-Losing Individuals - The Journal of Clinical Endocrinology & Metabolism Vol. 87, No. 4 1708-1716 - "We conclude that sLR levels are significantly decreased, whereas leptin levels are significantly increased in morbidly obese subjects compared with lean individuals"
• Insulin Resistance And Plasma Leptin Association Explained By Distinct Areas Of Body Fat Accumulation - Doctor's Guide, 4/4/02
• Severe Lipodystrophy Good Reason To Consider Leptin-Replacement Therapy - Doctor's Guide, 2/21/02
• Leptin Treatment of Obese Men Reduces Appetite But Not Weight - Doctor's Guide, 9/21/01
• Valproic Acid Linked To Endocrine Abnormalities In Women With Bipolar Disorder - Doctor's Guide, 8/9/01 - "Blood tests revealed higher levels of androgens and leptin among women taking valproic acid"
• Olanzapine's And Clozapine's Effect On Weight Gain Related To Insulin And Leptin - Doctor's Guide, 3/26/01 - "the median insulin level was significantly higher in olanzapine patients ... In the clozapine group, insulin levels were positively correlated to the drug serum concentration"
• New Fat-Loss Drug Resets Brain's Weight Setpoint - WebMD, 3/20/01 - "The drug, called Axokine, is a genetically engineered version of a natural brain chemical, called CNTF, that makes new brain cells grow ... [A] remarkable property that distinguishes ... A human trial reported at a medical meeting last month showed that obese people who got the most effective dose of Axokine lost nearly 10 pounds over 12 weeks of treatment. Unlike previous weight loss drugs, these patients did not immediately regain the weight -- in fact, they lost another pound during the first six weeks they were off the drug, and they kept their lost weight off for a minimum of six weeks after discontinuing the medication ... the drug works a lot like leptin ... Leptin would make a great weight loss drug -- except that when a person becomes obese, he becomes resistant to it the same way a diabetic person becomes resistant to insulin"
• How Sweet It Isn't: Hormone Dampens Taste for Sugary Foods, Finding Could Explain Why Some Obese People Can't Resist Sweets - WebMD, 9/18/00
• Endocrinology of Aging, Leptin, Obesity, and Aging - Medscape, 3/00
• Leptin - Can Obese Mice Lead to Lean People? - Michael D. Myers, M.D., Inc. - "In humans, obesity appears to result from a much more complex mechanism and is not associated with a lack of leptin. Recent clinical trials, however, have shown that large doses of leptin did result in at least some weight loss in obese individuals."
• Researchers try to make anti-fat hormone work better - CNN, 2/12/98
• Knowledge Of Weight Control Leading Way For Future Treatments - Doctor's Guide, 2/12/98
• Leptin Causes Death Of Fat Cells - Doctor's Guide, 10/21/97
• Resistance To Leptin Contributes To Obesity - Doctor's Guide, 8/5/97
• Leptin Has An Anti-Diabetic Effect, Say Researchers - Doctor's Guide, 4/29/97
• New Anti-Obesity Approach Acts Independently of Leptin - Doctor's Guide, 6/7/96