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Home > Anti-aging Research > L-Carnitine


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  • Science Reveals How Red Meat Harms the Heart - WebMD, 12/29/21 - "Researchers found that particular gut bacteria, more abundant in red-meat eaters, are key in turning a dietary nutrient called carnitine into a foe: a chemical known as TMAO, which helps promote blood-clotting and clogged arteries ... The traditional suspect was saturated fat, found almost exclusively in animal products. Saturated fat can boost "bad" LDL cholesterol, which contributes to cardiovascular disease ... But, Hazen said, research has shown that any ill effects of saturated fat are not enough to explain the excess heart disease risks linked to heavy red-meat consumption. There had to be other mechanisms ... Hazen, too, said he is a "big supporter" of using diet to change the gut microbiome, rather than adding certain bugs via probiotic supplements ... "Changing your diet changes the soil" that feeds gut microbes ... The researchers also analyzed stool samples from people who took part in the 2019 diet study. They found that when participants were eating a lot of red meat, their stool harbored more of the culprit E. timonensis microbes; when they switched to non-meat protein sources, those microbial levels dropped ... fermented foods like yogurt and kimchi, which contain certain microbes, can be good choices. But again, she stressed, overall diet is what's key in supporting a healthy gut" - What about prebiotics is your goal is to change the soil?
  • Oral Carnitine Supplementation Reduces Body Weight and Insulin Resistance in Women With Polycystic Ovary Syndrome - Medscape, 8/10/16 - "Overall, 12 weeks of carnitine administration in PCOS women resulted in reductions in weight, BMI, WC and HC, and beneficial effects on glycaemic control; however, it did not affect lipid profiles or free testosterone" - See L-carnitine at Amazon.com.
  • Nutritional supplement boosts muscle stamina in animal studies - Science Daily, 7/7/15 - "The researchers then introduced a carnitine supplement. Exercise tolerance improved only in animals with normal CrAT activity in muscle. Muoio said these results strongly imply that carnitine and the CrAT enzyme work together to optimize muscle energy metabolism during exercise" - See acetyl l-carnitine products at Amazon.com and l-carnitine at Amazon.com.
  • Serum Carnitine Level in Chronic Viral Hepatitis - Medscape, 7/1/14 - "64 out of 86 patients (74.4%) and 21 out of 86 (24.5%) healthy individuals suffered from carnitine deficiency (p < 0.001). Carnitine dietary intake was significantly lower (p < 0.001). Compared with patients with chronic hepatitis C infection, a more severe form of carnitine deficiency was detected in patients with chronic hepatitis B infection (18.39 ± 15.68 μmol/l vs 42.30 ± 32.92 μmol/l; p = 0.03)"
  • Carnitine Supplement May Improve Survival Rates of Children With Heart Defects - Science Daily, 5/8/13 - "The new study indicates that even without fixing the heart defect, high daily doses of carnitine in the first four weeks of life can prevent endothelial dysfunction. In fact, the laboratory lambs' ability to make nitric oxide is preserved even without the benefit of heart surgery and the responses to the chemical activity that enables blood vessel dilation is normalized"
  • L-carnitine significantly improves patient outcomes following heart attack, study suggests - Science Daily, 4/12/13 - "This systematic review of the 13 controlled trials in 3,629 patients, involving 250 deaths, 220 cases of new heart failure, and 38 recurrent heart attacks, found that L-carnitine was associated with: ... Significant 27% reduction in all-cause mortality (number needed to treat 38) ... Highly significant 65% reduction in ventricular arrhythmias (number needed to treat 4) ... Significant 40% reduction in the development of angina (number needed to treat 3) ... Reduction in infarct size ... These findings may seem to contradict those reported in a study published earlier this month in Nature Medicine by Robert A. Koeth and others (link below), which demonstrated that metabolism by intestinal microbiota of dietary L-carnitine produced trimethylamine N-oxide (TMAO) and accelerated atherosclerosis in mice" - Note:  I read that Koeth study and wasn't buying it with all the previous studies I had read.
  • CoQ10 and L-carnitine for Statin Myalgia? - Medscape, 1/4/13 - "In summary, it has been proposed that CoQ10 can help to treat statin myalgia. While this is not conclusive, there are two randomized controlled trials showing significant improvements in the severity of muscle pain with the use of CoQ10 in patients treated with statins. Thus, it is not unreasonable to supplement a patient who is experiencing muscle pains on a statin with CoQ10. While there are no clinical trials showing improvements in muscle pain with the use of l-carnitine, patients who experience statin myalgia frequently have carnitine abnormalities. It is too soon to recommend l-carnitine for statin myalgia, but future trials should test this supplement to see if it has any place for this adverse effect. Other common alternatives for treating statin myalgias are supplementation with vitamin D or vitamin B12, especially in the setting of suboptimal serum levels"
  • Lonza’s L-carnitine may boost exercise recovery: Study - Nutra USA, 8/12/10 - "Blood samples showed that L-carnitine supplementation significantly improved a range of biochemical markers, including purine metabolism, free radical formation, and muscle tissue disruption ... The l-carnitine l-tartrate supplementation therefore reduced both myoglobin and creatine kinase concentrations, providing additional evidence that LCLT reduces post-exercise muscle disruption ... Such findings support the additional findings that l-carnitine l-tartrate significantly reduced muscle soreness immediately after the exercise workout and at 24 and 48 hours postexercise when compared with the placebo condition" - [Abstract]
  • Carnitine Supplements Reverse Glucose Intolerance In Animals - Science Daily, 8/17/09 - "After just eight weeks of supplementation with carnitine, the obese rats restored their cells' fuel- burning capacity (which was shut down by a lack of natural carnitine) and improved their glucose tolerance, a health outcome that indicates a lower risk of diabetes ... These results offer hope for a new therapeutic option for people with glucose intolerance, older people, people with kidney disease, and those with type 2 diabetes (what used to be called adult-onset diabetes) ... Carnitine is a natural compound known for helping fatty acids enter the mitochondria, the powerhouses of cells, where fatty acids are "burned" to give cells energy for their various tasks. Carnitine also helps move excess fuel from cells into the circulating blood, which then redistributes this energy source to needier organs or to the kidneys for removal"
  • L-carnitine linked to better mental function in the very old - Nutra USA, 12/13/07 - "either the daily L-carnitine supplement (two grams, from Sigma Tau) or placebo for six months ... the supplementation with L-carnitine was associated with significant reductions in fat mass, compared to placebo. Indeed, the active supplement group lost 1.6 kg of fat mass, while the placebo group gained 0.6 kg ... Total muscle mass in the L-carnitine-supplemented group increased by three kilograms more than the placebo group ... Cognitive performance, measured using the 30-point Mini-Mental State Examination (MMSE), showed increases of 4.1 points for the L-carnitine group, compared to only 0.6 points on average for the placebo group" - [Abstract]
  • Four powerhouse nutrients - Functional Foods and Nutraceuticals, 4/05 - "L-carnitine shuttles fuel into cells to be burned as energy; coenzyme Q10 sparks the energy within the cells; ribose is a component of adenosine triphosphate (ATP); and alpha-lipoic acid increases ATP levels"
  • Sperm Swim Better With Carnitine - WebMD, 3/9/05 - "The finding could help men coping with fertility issues -- specifically, those men whose sperm don't move very well"
  • New uses for carnitine - Functional Foods and Nutraceuticals, 11/04 - "Because L-carnitine is central to the formation of energy from fat, the heart is therefore dependent on L-carnitine for most of its energy production ... L-Carnipure carries long-chain fatty acids into the mitochondria where they are oxidised for energy. Its ability to generate energy from fat makes carnitine useful as part of a weight management program ... L-carnitine plus its metabolite, acetyl-L-carnitine, can treat symptoms of male ageing, including sexual dysfunction, depressed mood and fatigue"
  • Carnitine Improves Symptoms of Male Aging - Medscape, 4/14/04 - "Carnitine is more active than testosterone for improving symptoms of male aging such as sexual dysfunction, depressed mood, and fatigue ... In this trial, 120 patients were randomized to receive testosterone undecanoate 160 mg/day, propionyl-L-carnitine 2 g/day plus acetyl-L-carnitine 2 g/day, or placebo for six months" [Abstract] - See GPLC at Amazon.com.
  • Better than testosterone? - Life Extension Foundation, 4/19/04 - "The April 2004 issue of the journal Urology published the findings ... Erectile function, sexual desire, sexual satisfaction and nocturnal penile tumescence increased over the course of the study in the group receiving testosterone as well as the group receiving carnitine. In addition, the group receiving carnitine experienced an increase in orgasm and general sexual well-being. Erectile function and nocturnal penile tumescence were significantly more improved in this group than in those receiving testosterone. While both treatments lowered depression scores, carnitine’s effect was greater"
  • L-Carnitine Effective for Attention Deficit-Hyperactivity Disorder - New Hope Natural Media, 12/19/02 - "According to the parents’ ratings, 54% of the children showed significant improvement in their behavior while taking L-carnitine, whereas only 13% improved during the placebo period. The teachers’ ratings showed a similar, though slightly less pronounced, advantage of L-carnitine over placebo" -  Also see acetyl-l-carnitine.
  • The Benefits of Carnitine and DHEA for Fat Metabolism - Life Extension Magazine, 8/02 - "Carnitine is an amino acid that's critical for converting fatty acids into fuel. Because of this, it has the potential to help people lose weight ... A lack of DHEA may be one of the primary causes of insulin resistance"