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Coleus forskohlii

Specific Recommendations:

• Coleus forskohlii products at Amazon.com
• Coleus forskohlii products at iHerb

News & Research:

• Herbal supplement may help treat recurrent bladder infections - USA Today, 4/8/07 - "If these results could be duplicated in human studies, forskolin could offer a new treatment option for recurrent" urinary tract infection"
• New Weight-control Options - Functional Foods & Nutraceuticals, 8/02
• Nutracon News - Nutrition Science News, 9/01 - "Although forskolin is active in the same metabolic pathway as ephedrine, it starts further down the pathway. Forskolin enhances adenylate cyclase, an enzyme that splits a high-energy molecule of adenosine triphosphate (ATP) to yield cyclic adenosine monophosphate (cAMP). Typically, an increase in cAMP leads to activation of other enzymes, among which is lipase. Lipase disposes of triglycerides, known as the building blocks of fatty tissue, which has a positive effect on body composition. The net effect is an increase in lean body mass and trimmed waistline"
• ForsLean.com
• Supplement Update: Coleus Forskohlii - ThinkMuscle.com - "The breakdown of fat for fuel (lipolysis) is actually regulated by cAMP. Forskolin has been shown to not only enhance lipolysis but it may also inhibit fat storage from occurring. This is very good news for individuals trying to lose bodyfat and get lean"

Abstracts:

• Forskolin, a hedgehog signaling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats - Br J Pharmacol. 2016 Sep 2 - "Our findings indicate that forskolin has a promising antifibrotic effect which could be partially attributed to its antioxidant, anti-inflammatory effects as well as inhibition of Hh signaling" - See Coleus forskohlii products at Amazon.com.
• Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial - Nutrients. 2015 Nov 17 - "Limited studies have shown that Coleus forskohlii extract may aid in weight management ... Thirty participants completed the trial and they were randomly assigned to receive either 250 mg of C. forskohlii extract (n = 15) or a placebo twice daily for 12 weeks ... The experimental group showed a favorable improvement in insulin concentration and insulin resistance (p = 0.001; 0.01 respectively) compared to the placebo group"
• Relationship between cyclic AMP production and lipolysis induced by forskolin in rat fat cells - J Lipid Res 1992 Feb;33(2):225-31