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Home > Health Conditions > Chronic Fatigue Syndrome

Chronic Fatigue Syndrome

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  • A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study - Front Nutr 2021 Nov 26 - "A total of 190 subjects (35-60 years old, non-obese) with CFS were randomized to receive one tablet of a low dose (120-mg ginkgo and 300-mg cistanche), a high dose (180-mg ginkgo and 450-mg cistanche) or a placebo once daily for 60 days. Blood samples and responses on the Chalder fatigue scale (CFQ 11), the World Health Organization's quality of life questionnaire (WHOQOL), and the sexual life quality questionnaire (SLQQ) were collected at baseline and post-intervention. CFS symptoms of impaired memory or concentration, physical fatigue, unrefreshing sleep, and post-exertional malaise were significantly improved (p < 0.001) in both of the treatment groups. The botanical intervention significantly decreased physical and mental fatigue scores of CFQ 11 and improved WHOQOL and SLQQ scores of the subjects (p < 0.01). Levels of blood ammonia and lactic acid in the treatment groups were significantly lower than those of the placebo group (low-dose: p < 0.05; high-dose: p < 0.01). In addition, the change in lactic acid concentration was negatively associated with the severity of CFS symptoms (p = 0.0108) and was correlated with the change in total physical fatigue score of the CFQ" - [Nutra USA] - See Ginkgo biloba at Amazon.com and cistanche at Amazon.com.
  • Robuvit®: improvement of fatigue in medical convalescence - J Sports Med Phys Fitness. 2018 May;58(5):678-683 - "Weakness and heart rate were significantly reduced with Robuvit® in comparison with the controls (P<0.05) at 10 days and at 3 weeks; Attention and sleep patterns improved significantly at 3 weeks with Robuvit® (P<0.05) in comparison to controls. Recovery after efforts was normalized at 10 days in the supplement group, significantly better versus controls (P<0.05). O2 saturation increased significantly with Robuvit® at 10 days in comparison to controls (P<0.05). The alterations in working/concentration capacity were better improved with the supplement (P<0.05). Oxidative stress was significantly decreased (P<0.05) in comparison to controls. The improvement of health according to the Karrnofsky Scale was significantly more pronounced in the Robuvit® group (P<0.05). The supplement was well tolerated" - See Robuvit® at Amazon.com.
  • Chronic Fatigue Syndrome Linked to Low T3 Syndrome - Medscape, 3/29/18 - "Some people with the condition known as chronic fatigue syndrome (CFS) have low circulating levels of the thyroid hormone triiodothyronine (T3) and normal levels of thyroid-stimulating hormone (TSH) ... This low T3 syndrome might be in line with recent metabolomic studies that point to a hypometabolic state (Proc Natl Acad Sci U S A. 2016;113:E5472-E5480), and if confirmed, T3 and iodide supplements may be indicated as treatments, say Núñez and colleagues" - See T3 at the Antiaging Store and iodine at Amazon.com.
  • Chronic fatigue syndrome possibly explained by lower levels of key thyroid hormones - Science Daily, 3/20/18 - "In hypothyroidism, the body tries to encourage thyroid hormone activity by releasing more thyroid-stimulating hormone -- however, this does not happen in patients with chronic fatigue syndrome ... the researchers compared thyroid function and markers of inflammation between 98 CFS patients and 99 healthy controls. Remarkably, the CFS patients had lower serum levels of certain key thyroid hormones such as triiodothyronine (T3) and thyroxine (T4), but normal levels of thyroid-stimulating hormone ... Additional analyses indicated that CFS patients had a lower urinary iodine status and low-grade inflammation, which possibly mirrored the symptoms of patients with hypothyroidism. These CFS patients, however, had relatively higher levels of another thyroid hormone called "reverse T3" or rT3. This appeared to be due to a shift in hormone production, where the body preferred to convert T4 to rT3 instead of producing T3. The low T3 levels found in CFS patients coupled with this switchover to rT3 could mean that T3 levels are severely reduced in tissue" - See T3 at the Antiaging Store and iodine at Amazon.com.
  • Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial - Clin Nutr. 2016 Aug;35(4):826-34 - "80 CFS patients assigned to receive either CoQ10 plus NADH supplementation or matching placebo twice daily ... The CoQ10 plus NADH group showed a significant reduction in max HR during a cycle ergometer test at week 8 versus baseline (P = 0.022). Perception of fatigue also showed a decrease through all follow-up visits in active group versus placebo (P = 0.03). However, pain and sleep did not improve in the active group. Coenzyme Q10 plus NADH was generally safe and well tolerated" - [Nutra USA] - See ubiquinol products at Amazon.com and nicotinamide adenine dinucleotide at Amazon.com.
  • New study shows chronic fatigue isn’t just in your head. It may have to do with your gut - Washington Post, 6/30/16 - "Cornell University researchers looked at stool and blood samples of 48 people diagnosed with chronic fatigue syndrome (or more formally, myalgic encephalomyelitis) and at 39 healthy volunteers ... They found two main differences: Through DNA sequencing, they found the stool samples in the patients with the condition had less diversity in bacteria present in the gut and that there were fewer that were anti-inflammatory. The blood samples were also distinct: There were markers of inflammation which the researchers theorized may be due to a "leaky gut from intestinal problems that allow bacteria to enter the blood." ... it suggests that diet and things like probiotics may be a way to help treat the disease by getting the gut microbiome back in balance" - See probiotic products at Amazon.com.
  • Probiotics a Potential Treatment for Mental Illness - Medscape, 11/19/13 - "although human studies are still largely lacking, they did find some with promising results on behavior, including 1 showing that healthy volunteers who received Lactobacillus helveticus R0052 plus B longum for 30 days reported significantly lower stress levels than those who received placebo, as well as significantly reduced urinary free cortisol levels ... Another study of 124 volunteers (mean age, 61.8 years) showed that those who consumed probiotic-containing yogurt for 3 weeks had significantly improved mood compared with those who received placebo ... the term "psychobiotic" was created as recent studies have begun to explore a possible link between probiotics and behavior ... As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid [GABA] and serotonin, which act on the brain-gut axis ... a study of human patients with chronic fatigue syndrome showed that those who consumed an active strain of L casei 3 times a day had significantly higher improvement scores on anxiety measures than did those who received matching placebo" - See probiotic products at Amazon.com.
  • Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells - Biol Pharm Bull. 2011;34(3):354-9 - "Neuroimaging evidence showed structural and/or functional abnormalities existing in the central nervous system, especially the hippocampus, in chronic fatigue syndrome (CFS) patients. However, its pathophysiologic mechanisms are unclear in part due to the lack of an applicable animal model. We established a chronic fatigue murine model by six repeated injections of Brucella abortus antigen to mice, which was manifested as reduced daily running activity and hippocampal atrophy. Thereafter, resveratrol, a polyphenolic activator of sirtuin 1, was used for treatment in this model. Daily running activity was increased by more than 20%, and the hippocampus was enlarged after 4-week resveratrol therapy. Furthermore, resveratrol inhibited neuronal apoptosis and expression of hippocampal acetylated p53 in the fatigue mice. Resveratrol also improved neurogenesis and expression of brain-derived neurotrophic factor mRNA in the hippocamous. We concluded that repeated injection of B. abortus antigen could induce hypoactivity and hippocampal atrophy in mice. Resveratrol may be effective for improving fatigue symptoms and enlarging the atrophic hippocampus by repressing apoptosis and promoting neurogenesis" - See resveratrol products at Amazon.com.
  • Polyphenol-rich choc may ease chronic fatigue symptoms: Study - Nutra USA, 11/23/10 - "either the high or low chocolate, followed by two weeks of washout and cross over on to the other intervention. The study used chocolate provided by Nestlé PTC York, UK ... Results showed a significant improvement in Chalder Fatigue Scale scores following the high polyphenol chocolate intervention, whereas a deterioration was observed in the low-polyphenol chocolate intervention" 
  • Treating Chronic Fatigue and Fibromyalgia? - Dr. Weil, 8/17/09
  • Treating Chronic Fatigue and Fibromyalgia? - Dr. Weil, 1/13/09
  • The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study - J Altern Complement Med. 2006 Nov;12(9):857-62 - "D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome" - See D-ribose at Amazon.com.
  • Focus on Magnesium - Dr. Murray's Natural Facts, 3/3/05 - "Double-blind studies in people with CFS have shown magnesium supplementation significantly improved energy levels, better emotional state, and less pain"
  • Exercise Helps Chronic Fatigue Syndrome - WebMD, 7/23/04
  • Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes - Int J Clin Pract. 2004 Mar;58(3):297-9 - "The EPA-rich essential fatty acid supplementation led to a marked clinical improvement in her symptoms of chronic fatigue syndrome, starting within 6-8 weeks" - See Mega Twin EPA at Amazon.com.
  • A Worthwhile Approach to Chronic Fatigue Syndrome? - Dr. Weil, 1/27/04
  • Melatonin, Phototherapy Ineffective in Chronic Fatigue Syndrome - Doctor's Guide, 11/14/02
  • Thymus Protein Effective in Treating Chronic Fatigue - New Hope Natural Media, 8/1/02 - "23 people with CFIDS received 12 mcg of thymic protein A per day by mouth for three months ... Positive changes included a reduction in fatigue, better quality of sleep, less anxiety and depression, and fewer panic attacks"
  • Chlorella for Chronic Fatigue? - Dr. Weil, 6/25/02
  • Chronic Fatigue: Its Own Entity - Functional Foods & Nutraceuticals, 2/02 - "Ninety per cent of patients with chronic fatigue who took omega-3 fatty acids for 3 months improved fatigue scores, with two-thirds regaining full-time duties."
  • Fighting Fatigue: Iron Overload vs. Anaemia - Functional Foods & Nutraceuticals, 2/02 - "Menstruating women are more likely to feel tired because of an iron deficiency, whereas men 40 years and older are more likely to tire from iron overload ... the anaemia rate of adults older than 85 may be similarly high—ranging from 17 to 28 per cent ... In a state of iron overload, fatigue is often accompanied by arthritis, diabetes, infertility, male impotence, skin pigmentation, and liver or heart disease ... unexplained fatigue may be a physical symptom of masked depression"
  • Graded Exercise Benefits Patients With Chronic Fatigue Syndrome - Doctor's Guide, 2/16/01
  • Chronic Fatigue News - Nutrition Science News, 4/00
  • Enada Reduces Chronic Fatigue Symptoms - Nutrition Science News, 8/99
  • Exercise Helps Patients With Chronic Fatigue Feel Better - Doctor's Guide, 6/6/97

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