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Home > Anti-aging Research > Licorice


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  • Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial - Phytother Res 2022 Jul 3 - "This study aimed to evaluate the effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease (NAFLD). In this randomized double-blind, placebo-controlled trial, 60 women with NAFLD were selected and randomly assigned into 2 groups to take 1,000 mg/day powder of licorice root extract or placebo for 12 weeks. In addition, all the patients were advised to follow a weight loss diet and healthy lifestyle ... Through the 12-weeks period of supplementation, women who received powder of licorice root experienced a statistically significant improvement in alanine aminotransferase (p < .001), insulin (p = .002), insulin resistance (p = .003), malondialdehyde (p < .001) serum levels, and ultrasonographic findings of liver steatosis (p < .001), compared to the placebo group. In conclusion, licorice root supplementation in addition to gradual weight loss and lifestyle modification is superior to lifestyle modification alone for the treatment of NAFLD" - See licorice supplements at Amazon.com.
  • Licorice flavonoid oil supplementation promotes a reduction of visceral fat in exercised rats - J Sports Med Phys Fitness 2020 Oct 1 - "Exercise or licorice flavonoid oil supplementation resulted in the reduction of the visceral fat mass and adipocyte size, respectively. In addition, exercise combined with licorice flavonoid oil supplementation more effectively decreased both of these measures. Exercise alone increased the β-hydroxyacyl-CoA dehydrogenase (β-HAD) and citrate synthase (CS) activities from the soleus and plantaris muscles, and licorice flavonoid oil supplementation alone increased the hepatic carnitine palmitoyl transferase-2 (CPT-2) activity. Furthermore, the combination of exercise and licorice flavonoid oil supplementation enhanced the both muscular β-HAD and CS activities, and hepatic CPT-2 activity"
  • Involvement of BID Translocation in Glycyrrhetinic Acid and 11-Deoxy Glycyrrhetinic Acid-Induced Attenuation of Gastric Cancer Growth - Nutr Cancer. 2014 Feb 18 - "Glycyrrhetinic acid (GA), the main chemical constituents of licorice, has shown remarkable anticancer activity. However, the side effects limit its widespread use. 11-DOGA is produced through reduction of GA 11-carbonyl to 11-hydroxyl to reduce its side effects, although its anticancer activities are largely unknown. Here, we report that the functional mechanisms of GA and 11-DOGA in gastric cancers, as well as the comparison between these two drugs' pharmacological potential. Firstly, we found that GA and 11-DOGA significantly inhibits the viabilities of gastric cancer cells in dose- and time-dependent manners. Both GA and 11-DOGA induce gastric cancer cells apoptosis and cell cycle arrest in G2 phase by upregulation of p21 and downregulation of cdc2 and cyclin B1. Further studies show that GA and 11-DOGA-induced apoptosis in gastric cancer cells is associated with BID translocation from nucleus to mitochondria. Moreover, GA and 11-DOGA could effectively inhibit tumor formation of gastric cancer cells in nude mice" - Note:  One of those side effects is that licorice increases cortisol which is not good for most people.  See licorice supplements at Amazon.com.
  • Grapefruit juice and liquorice increase cortisol availability in patients with Addison's disease - Eur J Endocrinol. 2011 Sep 6 - "Compared to the ordinary treatment, the median AUC for serum cortisol increased with liquorice (53783 vs. 50882, p<0.05) and GFJ (60661 vs. 50882, p<0.05). Cortisol levels in serum were also elevated 2.6h after tablet ingestion (liquorice 223 vs. 186 nmol/L, p<0.05; GFJ 337 vs. 186 nmol/L, p<0.01). Liquorice increased the median urinary cortisol/cortisone-ratio (0.43 vs 0.21, p<0.00001), whereas GFJ increased the (aTHF+THF)/THE-ratio (0.55 vs 0.43, p<0.05)" - Note:  From my readings, most have too much cortisol already.  I've read where licorice increases it.  Licorice and grapefruit juice sounds like an unlikely combination but people might want to be aware of it.
  • The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient - Neth J Med. 2005 Apr;63(4):149-50
  • Licorice consumption and serum testosterone in healthy man - Exp Clin Endocrinol Diabetes. 2003 Sep;111(6):341-3 - "The mean testosterone values decreased by 26 % after one week of treatment"