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Home > Health Conditions > Wrinkles

Wrinkles and other skin damage

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  • Oral Administration of Mixed Probiotics Improves Photoaging by Modulating the Cecal Microbiome and MAPK Pathway in UVB-Irradiated Hairless Mice - Mol Nutr Food Res 2023 Apr 20 - "Continuous ultraviolet (UV) exposure causes skin photoaging, wrinkle formation, and skin barrier damage. In this study, the protective effect of mixed probiotics (MP) against photoaging in UVB-irradiated Hs68 fibroblasts and SKH-1 hairless mice was investigated ... Collectively, these findings suggest that MP modulates the gut microbiome and ameliorates UVB-induced photoaging by downregulating the MAPK pathway" - See probiotic supplements at Amazon.com.
  • Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review - Adv Ther 2023 Jan 30 - "Metformin has shown multiple effects beyond its widely known antidiabetic effect. Impressively, it has already been proposed as an anti-aging factor. However, the potentially protective role of metformin in skin aging, the most common manifestation of aging, is not well examined. Existing evidence based on experimental studies suggests a potential anti-aging effect on skin. Proposed molecular skin anti-aging mechanisms of metformin include mainly reduction of nuclear factor kappa B (NF-κB) (p65) activity. Moreover, metformin appears to inhibit ultraviolet B (UVB)-induced secretion of pro-inflammatory cytokines" - See metformin at ReliableRX.
  • Ginsenoside Rk1 Prevents UVB Irradiation-Mediated Oxidative Stress, Inflammatory Response, and Collagen Degradation via the PI3K/AKT/NF-κB Pathway In Vitro and In Vivo - J Agric Food Chem 2022 Dec 6 - "Long-term exposure to ultraviolet (UV) irradiation, especially UVB, can trigger destructive intracellular effects, including various types of DNA damage, oxidative stress, and inflammatory responses, leading to accelerated skin aging. Ginsenoside Rk1, a rare ginsenoside pertaining to panaxadiol saponins, has been certified to possess underlying anti-inflammatory effects. Nevertheless, the efficiency of Rk1 against the photoaging of human skin and the latent molecular mechanisms are still unclear ... The UVB-induced inflammatory response was alleviated by Rk1 application via regulation of the secretion of various proinflammatory cytokines. Additionally, western blot assays illustrated that Rk1 intervention inhibited collagen degradation by reducing the expression of matrix metalloproteinases. Further studies revealed that Rk1 could suppress the PI3K/AKT/NF-κB signaling pathways in vitro and in vivo. Molecular docking results indicated that Rk1 might effectively bind to the active pockets of PI3K, AKT, and NF-κB. The PI3K activator 740 Y-P clearly reversed the effects of Rk1 on oxidative stress, the inflammatory response, and collagen degradation in UVB-irradiated HaCaT cells. Moreover, histological and Masson staining verified that the administration of Rk1 to BALB/c nude mice remarkably ameliorated UVB-induced skin roughness, epidermal thickening, collagen fiber arrangement disorder, and wrinkles. Overall, the evidence provided in this study suggested that Rk1 could be applied for the development of effective natural antiphotoaging agents for skin health" - See ginseng at Amazon.com.
  • Pomegranate natural extract Pomanox® positively modulates skin health-related parameters in normal and UV-induced photoaging conditions in Hs68 human fibroblast cells - Int J Food Sci Nutr 2022 Dec 1 - "Skin photoaging is primarily caused by ultraviolet radiation and can lead to the degradation of skin extracellular matrix components, resulting in hyperpigmentation and skin elasticity loss. In this area, polyphenols have become of great interest because of their antioxidant, anti-inflammatory and antiaging properties. Here, we evaluated the effects of the pomegranate natural extract Pomanox® on skin health-related parameters in normal and UV-induced photoaging conditions in human fibroblast Hs68 cells. Moreover, the inhibitory effects of Pomanox® on tyrosinase activity were assessed. In normal conditions, Pomanox® significantly modulated collagen and hyaluronic acid metabolisms. In UV-exposed cells, both preventive and regenerative treatments with Pomanox® positively modulated hyaluronic acid metabolism and decreased ROS levels. However, only the preventive treatment modulated collagen metabolism. Finally, Pomanox® showed a marked inhibitory capacity of tyrosinase activity (IC50 = 394.7 μg/mL). The modulation of skin health-related parameters exhibited by Pomanox® open a wide range of potential applications of this product" - See pomegranate extract at Amazon.com.
  • Cranberry Juice Polyphenols Inhibited the Formation of Advanced Glycation End Products in Collagens, Inhibited Advanced Glycation End Product-Induced Collagen Crosslinking, and Cleaved the Formed Crosslinks - J Agric Food Chem 2022 Dec 1 - "Collagens in the human skin are susceptible to glycation due to their long half-life of about 15 years, accumulating advanced glycation end products (AGEs). The formation of AGEs and the subsequent AGE-induced collagen crosslinking are major factors for skin aging. The objective of this study was to determine the capacity of cranberry juice polyphenols (CJPs) and their fractions to inhibit collagen glycation and to break AGE-induced crosslinks in collagens ... All the fractions significantly inhibited collagen glycation assessed with the collagen-methylglyoxal (MGO) or collagen-dehydroascorbic acid (DHAA) assays ... Results suggested that procyanidins were the most effective antiglycation agent in both collagen glycation assays, followed by flavonols and anthocyanins. High-performance liquid chromatography-electrospray ionization─tandem mass spectrometry showed that the reactions of DHAA with quercetin or epicatechin formed several adducts with unreported proposed structures. This study suggested that CJPs may be used as active ingredients in cosmetics to prevent skin collagen glycation and crosslinking and to break the formed crosslinks" - See cranberry extract at Amazon.com.
  • On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health - Antioxidants (Basel) 2022 Nov 17 - "The relationship between oxidative stress and skin aging/disorders is well established. Many topical and oral antioxidants (vitamins C and E, carotenoids, polyphenols) have been proposed to protect the skin against the deleterious effect induced by increased reactive oxygen species production, particularly in the context of sun exposure. In this review, we focused on the combination of vitamin E and selenium taken in supplements since both molecules act in synergy either by non-enzymatic and enzymatic pathways to eliminate skin lipids peroxides, which are strongly implicated in skin and hair disorders." - See vitamin E at Amazon.com and se-methyl l-selenocysteine at Amazon.com.
  • First-in-Class Device for Facial Wrinkles Hits the Market - Medscape, 10/28/22 - "It doesn't do anything equivalent to a facelift, but the concept is a facelift by thousands of micro-punch excisions," said Avram, director of laser, cosmetics, and dermatologic surgery at Massachusetts General Hospital. "Rather than pulling up the skin and lifting it and cutting the excess skin like we do with a facelift, we are creating thousands of smaller-scale tissue removals with immediate closures to do the same thing. The micro-cores are about the size of a 22-gauge needle and there is no scarring due to the small size of these tissue extractions. ... In a pivotal trial of the device, 51 patients with mid to lower face wrinkles (moderately deep or deep wrinkles with well-defined edges) were treated 2-3 times with 7%-8% skin removal and up to a 5-mm needle coring depth). The investigators found that 40% of study participants achieved an improvement of 2 grades on the Lemperle Wrinkle Severity Scale and that the rate of overall satisfaction (slightly, somewhat, and extremely satisfied) was 86% ... In addition, 90% showed improvement of treated sites on the Global Aesthetic Improvement Scale, and 70% were comfortable enough to go out in public or return to work 3 days after treatment. Common side effects that can occur immediately post treatment include redness, swelling, and pinpoint bleeding, which typically clear in a few days"
  • Biological effects of the olive tree and its derivatives on the skin - Food Funct 2022 Oct 25 - "Numerous studies have pointed out the protective effect of olive compounds on skin ageing, thanks to their role in the different mechanisms involved in the ageing process, such as reducing oxidative stress, increasing cell viability and decreasing histological alterations. With regard to their photoprotective effect, the olive tree and its fruit contain phenolic compounds which have a protective effect against radiation, such as low ultraviolet absorption and high antioxidant activity, acting as a protective factor against photocarcinogenesis. Similarly, the anti-tumour effects of olives have been studied at the level of the different compounds and extracts obtained from them, and their ability to selectively attack human melanoma cells has been observed. They have also shown antibacterial activity against microorganisms particularly implicated in skin infections, such as Escherichia coli, Candida albicans, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa and Proteus spp. Likewise, on healthy tissue, they have shown the ability to stimulate growth, migration and the expression of genes involved in cell differentiation, which favours the regeneration of skin wounds" - See olive leaf extract at Amazon.com.
  • Antiskin Aging Effects of Indole Alkaloid N-Glycoside from Ginkgo Fruit ( Ginkgo biloba fruit) on TNF-α-Exposed Human Dermal Fibroblasts - J Agric Food Chem 2022 Oct 17 - "Human skin aging has internal and external factors, both of which are characterized by TNF-α overproduction. Therefore, we aimed to identify a natural product that suppresses the damage that occurs in cutaneous dermal fibroblasts exposed to TNF-α. The protective effects of the indole alkaloid N-glycoside, ginkgoside B dimethyl ester (GBDE), isolated from ginkgo fruit (Ginkgo biloba fruit) were evaluated in TNF-α stimulated human dermal fibroblasts (HDFs) ... GBDE also reduced the expression of COX-2 to 2.06 ± 0.12-fold (p < 0.001) and increased the expression of HO-1 to 10.64 ± 0.2-fold (p < 0.001). In addition, GBDE inhibited the expression of the pro-inflammatory cytokines (IL-8, 2.2 ± 0.0; IL-1β, 1.6 ± 0.0; IL-6, 2.0 ± 0.10-folds, p < 0.05). These results provide experimental evidence that GBDE can protect against skin damage, including aging" - See Ginkgo biloba at Amazon.com.
  • Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1 - Food Funct 2022 Oct 13 - "Microvascular loss is one of the most important characteristics of skin aging and several microvascular activities play key roles in preserving skin health. In vitro, lycopene (Ly) reduced the contents of reactive oxygen species (ROS), β-galactosidase, and advanced glycosylation end products (AGEs), while increasing the contents of ATP and NAD+/NADH along with the mitochondrial membrane potential (MMP) ... In summary, all data demonstrated that Ly might reverse insulin resistance via SIRT1 during skin aging and promote microvascular neovascularization to protect aging skin" - See lycopene at Amazon.com.
  • Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts - Evid Based Complement Alternat Med 2022 Jun 28 - "To investigate the effects and corresponding mechanisms of total flavonoids (TFL) from Lycium barbarum leaves on photoaged human dermal fibroblasts (HDFs) ... TFL could inhibit oxidative stress and apoptosis, promote cell proliferation and the level of ECM-related component proteins, and participate in antiphotoaging in a concentration-dependent manner. The protective role of TFL in photoaged HDFs might be related to its inhibition of MAPK signaling pathways" - See flavonoids at Amazon.com.
  • Anti-Photoaging Effect of Rhodiola rosea Fermented by Lactobacillus plantarum on UVA-Damaged Fibroblasts - Nutrients 2022 Jun 1 - "UVA can cause oxidative stress and photoaging of cells. We established a UVA-induced oxidative stress model of human fibroblasts and focused on the antioxidant and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea. Compared with the unfermented Rhodiola rosea, Lactobacillus plantarum fermented Rhodiola rosea has better DPPH free radical and hydroxyl free radical scavenging ability, significantly reduces the content of reactive oxygen species (ROS), and improves the antioxidant level. Further studies have shown that the Lactobacillus plantarum fermented Rhodiola rosea can activate the Nrf2/Keap1 signaling pathway and up-regulate heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT) and glutathione Peptide peroxidase (GSH-Px), and protect fibroblasts from oxidative stress caused by UVA. On the other hand, Lactobacillus plantarum fermented Rhodiola rosea significantly reduces the activity of metalloproteinases in the cell, thereby increasing the collagen and elastin in the cell, alleviating the photoaging caused by UVA. Finally, we concluded that the antioxidant capacity and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea are better than that of unfermented Rhodiola rosea" - See fermented Rhodiola rosea (It doesn't show any fermented. Google shows several studies on fermented but none for sale).
  • Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells - Front Med (Lausanne) 2022 May 24 - "Skin expansion by mechanical stretch is an essential and widely used treatment for tissue defects in plastic and reconstructive surgery; however, the regenerative capacity of mechanically stretched skin limits clinical treatment results. Here, we propose a strategy to enhance the regenerative ability of mechanically stretched skin by topical application of metformin ... Compared with the control group, metformin treatment was beneficial to mechanical stretch-induced skin regeneration by increasing the thicknesses of epidermis (57.27 ± 10.24 vs. 31.07 ± 9.06 μm, p < 0.01) and dermis (620.2 ± 86.17 vs. 402.1 ± 22.46 μm, p < 0.01), number of blood vessels (38.30 ± 6.90 vs. 17.00 ± 3.10, p < 0.01), dermal collagen volume fraction (60.48 ± 4.47% vs. 41.28 ± 4.14%, p < 0.01), and number of PCNA+, Aurora B+, and pH3+ cells. Additionally, we observed significant elevations in the number of proliferating hair follicle bulge stem cells [cytokeratin (CK)15+/proliferating cell nuclear antigen (PCNA)+] (193.40 ± 35.31 vs. 98.25 ± 23.47, p < 0.01) and epidermal stem cells (CK14+/PCNA+) (83.00 ± 2.38 vs. 36.38 ± 8.96, p < 0.01) in the metformin-treated group, and western blot results confirmed significant increases in CK14 and CK15 expression following metformin treatment" - See metformin at ReliableRX.
  • Hesperidin Inhibits UVB-Induced VEGF Production and Angiogenesis via the Inhibition of PI3K/Akt Pathway in HR-1 Hairless Mice - Biol Pharm Bull 2021;44(10):1492-1498 - "Hesperidin is a citrus flavanone glycoside with potent anti-inflammatory effects that interferes with UVB-stimulated angiogenesis in skin ... We found hesperidin treatment inhibited skin neovascularization skin induced by repetitive UVB light exposure. Exposure to UVB radiation induces the expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase-13 (MMP-13), and MMP-9, but we found all of these were inhibited by treatment with hesperidin ... Because it affects the mediators of angiogenesis, our data suggest hesperidin has an anti-angiogenic effect on the pathologic skin neovascularization induced by UVB light. Thus, hesperidin may prove useful in the treatment of skin injuries caused by UVB light exposure" - See hesperidin at Amazon.com and hesperidin at iHerb.
  • Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study - Molecules 2021 Aug 12 - "A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage ... A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage" - [Nutra USA] - See hydrolyzed fish cartilage at Amazon.com.
  • Panax ginseng C. A. Meyer Phenolic Acid Extract Alleviates Ultraviolet B-Irradiation-Induced Photoaging in a Hairless Mouse Skin Photodamage Model - Evid Based Complement Alternat Med 2021 Aug 2 - "Here, we evaluated the in vivo skin-protective effects of topical applications of Panax ginseng C. A. Meyer extract (PG2) and its phenolic acid- (PA-) based components against UVB-induced skin photoaging. PG2 or PA applied to skin of hairless mice after UVB-irradiation alleviated UVB-induced effects observed in untreated skin, such as increased transepidermal water loss (TEWL), increased epidermal thickness, and decreased stratum corneum water content without affecting body weight. Moreover, PG2 and PA treatments countered reduced mRNA-level expression of genes encoding filaggrin (FLG), transglutaminase-1 (TGM1), and hyaluronan synthases (HAS1, HAS2, and HAS3) caused by UVB exposure and reduced UVB-induced collagen fiber degradation by inhibiting the expression of matrix metalloproteinase genes encoding MMP-1, MMP-2, and MMP-9. Meanwhile, topical treatments reduced cyclooxygenase-2 (COX-2) mRNA-level expression in photodamaged skin, leading to the inhibition of interleukin-1β (IL-1β) and interleukin-6 (IL-6) mRNA-level expression. Thus, ginseng phenolic acid-based preparations have potential value as topical treatments to protect skin against UVB-induced photoaging" - See Panax ginseng at Amazon.com and iHerb.
  • Alpha-Tocopherol Protects Human Dermal Fibroblasts by Modulating Nitric Oxide Release, Mitochondrial Function, Redox Status, and Inflammation - Skin Pharmacol Physiol 2021 Jul 8 - "human dermal fibroblasts (HDF) ... α-Tocopherol exerts protective effects in HDF which underwent oxidative stress by modulating the redox status, inflammation, iNOS-dependent NO release, and mitochondrial function. These observations have a potential role in the prevention and treatment of photoaging-related skin cancers" - See vitamin E at Amazon.com and iHerb.
  • Retinoids remain the gold standard for fighting acne and wrinkles. Here’s what you should know. - Washington Post, 5/4/21 - "Since Kligman’s 1986 work, there have been thousands of studies on tretinoin, making it one of the most researched anti-aging ingredients in dermatology. “Tretinoin is considered the gold standard in skin care because of the extensive body of research that supports how well it works at increasing cell turnover,” said Ranella Hirsch, a dermatologist based in Cambridge, Mass. This boost in cell turnover helps increase collagen production, unclog pores (one way it helps treat acne), smooth fine lines, reduce the appearance of sun damage and manage dark spots, Hirsch added ... The key to safely and tolerably introducing a retinoid is not only to start with a low strength but to only apply a pea size of the retinoid two to three times per week, depending on your skin’s tolerability, Rieder said. “I love to start my patients on retinol or retinaldehyde [retinal] for a month or two, and then transition them to prescription-strength tretinoin,” said Sarvenaz Zand, a dermatologist based in Marin County, Calif. “This regimen helps to avoid all the irritation, peeling and redness that you can get with starting a prescription-strength retinoid right off the bat.” ... if you have a retinoid in your routine you should always wear proper sunscreen and moisturizer to prevent irritation ... Rieder emphasized patience when it comes to seeing results from retinoids, whether using them for the treatment of acne or wrinkles. “I always tell my patients that in the beginning you’re going to ask yourself, ‘Why the hell am I doing this to my skin?’ after having irritated, flaky skin for weeks and not seeing any difference at all. It’s like that six-month point, that one-year point that you really start seeing results. But it’s a journey, a long journey.”" - See Retin-A at ReliableRxPharmacy.
  • Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study - Skin Pharmacol Physiol 2021;34(3):135-145 - "Oral supplementation with a standardized extract from the bark of the French pine (Pycnogenol®) has been reported to benefit the skin ... In a monocentre, double-blind, randomized, placebo-controlled, and crossover study, the effects of Pycnogenol® intake (2 × 50 mg/day for a total of 12 weeks) on a variety of skin physiological parameters was studied in Chinese subjects (n = 76), from spring to autumn, who were working outdoors in Beijing, China ... During the intervention period, study subjects were constantly exposed to increased levels of particulate matter (PM)2.5 as well as seasonal changes in humidity and temperature. Despite this environmental stress, Pycnogenol® intake prevented (i) a decrease in the skin hydration, (ii) transepidermal water loss (TEWL), and (iii) skin darkening during the dry autumn season. In addition, Pycnogenol® intake improved (iv) viscoelastic skin properties such as gross elasticity and elastic recovery irrespective of the season. These beneficial effects were not observed if the same subjects were supplemented with placebo" - [Nutra USA] - See Pycnogenol at Amazon.com.
  • LED masks to fight wrinkles: Here's what you should know - Washington Post, 4/20/21 - "Deciding which device to purchase is difficult. Amazon lists more than 500 tools for facial light therapy, and even skin-care professionals have trouble evaluating product claims. At the very least, dermatologists said, shoppers should choose a device that’s cleared by the Food and Drug Administration, meaning the agency has deemed it to be sufficiently safe for at-home use on all skin types. But be aware: that doesn’t necessarily mean the device is effective, just that it’s unlikely to cause injury. Check out the manufacturer’s credentials before buying, follow the directions and do not use for longer than recommended ... It may also help to ask dermatologists and estheticians for input. Czech said she has been recommending the $1,800 Celluma Pro, which has a flexible panel designed to conform to any part of the body, based on her experience with the brand and feedback from clients." - See facial light therapy at Amazon.com.
  • Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study - Skin Pharmacol Physiol 2021 Mar 31 - "Oral supplementation with a standardized extract from the bark of the French pine (Pycnogenol®) has been reported to benefit the skin. It might thus represent an easy-to-use strategy to improve the skin health of individuals who are exposed to considerable environmental stress in large urban areas ... During the intervention period, study subjects were constantly exposed to increased levels of particulate matter (PM)2.5 as well as seasonal changes in humidity and temperature. Despite this environmental stress, Pycnogenol® intake prevented (i) a decrease in the skin hydration, (ii) transepidermal water loss (TEWL), and (iii) skin darkening during the dry autumn season. In addition, Pycnogenol® intake improved (iv) viscoelastic skin properties such as gross elasticity and elastic recovery irrespective of the season. These beneficial effects were not observed if the same subjects were supplemented with placebo" - See Pycnogenol at Amazon.com.
  • Oral Supplementation of Collagen Peptides Improves Skin Hydration by Increasing the Natural Moisturizing Factor Content in the Stratum Corneum: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial - Skin Pharmacol Physiol 2021 Mar 26 - "collagen peptides (CPs) ... A randomized, placebo-controlled, double-blind trial was conducted in 99 healthy Japanese women, aged 35-50 years. The subjects were randomized into 3 groups (33 subjects/group) to receive 1 or 5 g of CP or placebo once daily for 12 weeks ... The level of natural moisturizing factor (NMF) constituents in the stratum corneum (SC) was quantified before treatment and after 12 weeks of treatment ... The improvement in skin water content following the oral ingestion of CP can be attributed to an increase in the level of NMF in the SC" - See collagen supplements at Amazon.com.
  • Safety and Efficacy of Oral Polypodium leucotomos Extract in Healthy Adult Subjects - J Clin Aesthet Dermatol. 2015 Feb; 8(2): 19–23 - "Polypodium leucotomos extract 240mg taken twice daily for 60 days was a safe and effective means for reducing the damaging effects of ultraviolet radiation ... Each capsule contains 240mg of P. leucotomos extract (Heliocare® Capsules; Ferndale Healthcare®, Inc.). The placebo was an inert capsule of similar appearance." - Note: I went to a demonologist at Scripps about veins on my cheek that were painful and was surprised that he recommended Heliocare which I was already taking but only one capsule per day. See Heliocare at Amazon.com.
  • Effect of Oral Supplement “Lycopene” On Reducing the Signs of Skin - Clin Pharmacol Biopharm 2020, 9:2 - "Results indicated a statistically significant increase in skin carotenoid levels in subjects who ingested Lycoderm, but no remarkable change in the placebo group. There was also a significant reduction in the appearance of lines and wrinkles in subjects using Lycoderm. The subjects noticed multiple skin benefits such as skin brightness and tonality, skin hydration and overall skin condition after using Lycoderm. Based on the confines and conditions of this study oral supplementation with Lycoderm resulted in significant increase in skin carotenoid level as well as tangible benefits to skin" - [Nutra USA] - See lycopene at Amazon.com and iHerb.
  • The Combination of Sulforaphane and Fernblock ® XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines - Nutrients 2020 May 30 - "we investigated in vitro the antioxidant/antineoplastic efficacy and anti-aging activity of a dietary supplement containing sulforaphane (SFN), a sulfur-isothiocyanate present in broccoli, combined with the patented extract Fernblock® XP (FB), obtained from the tropical fern Polypodium leucotomos. We evaluated the effect of SFN and FB, alone or in combination, on migration ability, matrix metalloproteinases (MMP) production, neoangiogenic potential and inflammasome activation in human WM115 and WM266-4 melanoma cells. Moreover, the effects on MMPs and reactive oxygen species production, and IL-1β secretion were studied in human normal keratinocytes. The SFN/FB combination inhibited melanoma cell migration in vitro, MMP-1, -2, -3, and -9 production, inflammasome activation and IL-1β secretion more efficiently than each individual compound did. In normal keratinocytes, SFN/FB was more efficient than SFN or FB alone in inhibiting MMP-1 and -3 production and IL-1β secretion in the presence of a pro-inflammatory stimulus such as TNF-α. The potential use of SFN/FB based supplements for the prevention of skin aging and as adjuvants in the treatment of advanced melanoma is suggested" - See Fernblock at Amazon.com.  See sulforaphane at Amazon.com and iHerb.
  • Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study - Nutrients 2020, 12(6) - "Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks ... Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging" - [Nutra USA] - See Hydrangea serrata supplements at Amazon.com.
  • The Protective Effect of Rosmarinic Acid Against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts - Nutrients. 2020 May 1 - "Parabens, which are widely used in food, medicines and cosmetics, have a harmful effect on human health. People are most exposed to parabens transdermally by using cosmetic products containing these preservatives. The purpose of this study was to estimate the influence of parabens (methylparaben-MP and propylparaben-PP) on the metabolism of collagen in the human skin fibroblasts and above all, to assess whether rosmarinic acid (RA-50, 100, or 150 M) can protect these cells from the adverse effects of parabens (0.001% MP and 0.0003% PP, 0.003% MP and 0.001% PP, and ​​0.01% MP and 0.003% PP). The possible mechanisms of RA action were estimated as well. Parabens decreased the expression of collagen type I and III at mRNA and protein levels, while RA (depending on the concentration) provided partial or total protection against these changes. The effective protection against the adverse effects of parabens on cell viability and proliferation was also provided by RA. The beneficial impact of RA on collagen and the fibroblasts resulted from an independent action of this compound and its interaction with parabens. This study allows us to conclude that this polyphenolic compound may protect from unfavorable health outcomes caused by lifetime human exposure to parabens contained in cosmetic products" - See rosemary extract at Amazon.com and rosemary extract at iHerb.
  • Oral administration of a novel hydrolyzed chicken sternal cartilage extract (BioCell Collagen®) reduces UVB-induced photoaging in mice - J Funct Foods. 2020 May - "Excessive exposure to ultraviolet B (UVB) radiation causes skin aging (a process known as photoaging). This study examined whether subchronic (14-week) oral administration of a novel hydrolyzed chicken sternal cartilage extract—comprising naturally-occurring primarily hydrolyzed type II collagen peptides, chondroitin sulfate and hyaluronic acid, extracted from a single source—could reduce signs associated with photoaging in hairless mice. Administration of the extract to UVB-irradiated mice led to significant increases in skin elasticity and hyaluronic acid content, compared with UVB-irradiated controls. Matrix metalloproteinase expression, transepidermal water loss, dermal inflammatory cells and wrinkles were all significantly reduced by administration of hydrolyzed chicken sternal cartilage extract. This study is the first to demonstrate that oral administration of this novel extract, containing a unique single-source complex of primarily hydrolyzed type II collagen (rather than the more widely studied type I form), chondroitin sulfate and hyaluronic acid, reduces UVB-induced photoaging in hairless mice." - [Nutra USA] - See Biocell Collagen II at Amazon.com and Biocell Collagen II at iHerb.com.
  • Orally administered mixed carotenoids protect human skin against ultraviolet A‐induced skin pigmentation: A double‐blind, placebo‐controlled, randomized clinical trial - Photodermatol Photoimmunol Photomed. 2020 Feb 18 - "60 subjects (Fitzpatrick types II-IV) were randomized to receive Nutrilite™ Multi Carotene supplement or placebo for 12 weeks ... In the intervention group, a significant increase in comparison with the placebo group was observed in (a) skin carotenoid levels, (b) UVB-induced MED, and (c) UVA-induced MPPD values obtained by colorimetry ... Daily supplementation with carotenoids protects human skin against both UVB-induced erythema and UVA-induced pigmentation" - [Nutra USA] - See mixed carotenoids at Amazon.com and mixed carotenoids at iHerb.com.
  • Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System - Nutrients. 2020 Apr 13 - "The combination of ascorbic acid and rutin, commonly used in oral preparations for their antioxidant and anti-inflammatory properties, can also be used to protect skin cells from the effects of UV radiation in sunlight ... Proteomic findings revealed a combined effect of ascorbic acid and rutin in UV-irradiated fibroblasts against overexpression of pro-inflammatory signaling proteins and DNA reorganization/expression. These effects were not observed when cells were treated with either compounds alone. The antioxidant effects of ascorbic acid and rutin also prevented protein modifications by lipid peroxidation products. Further, ascorbic acid stimulated rutin-protein adduct formation, which supports intra/extracellular signaling and the Nrf2/ARE antioxidant pathway, contributing to the protective effects against UV-induced oxidative stress. The combined effect of ascorbic acid and rutin suggests that this combination of compounds is potentially effective against skin damage caused by UV radiation" - See rutin at Amazon.com and rutin at iHerb.com and vitamin C products at Amazon.com and vitamin C at iHerb.com.
  • Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies - J Diet Suppl. 2020 Mar 23 - "AST supplementation improved skin texture, appearance (wrinkles), and moisture content at the end of the study period. AST also appeared to protect against UV-induced skin damage. No serious adverse events were reported in any of the studies. However, most available studies had a relatively small sample size and were conducted on healthy Japanese females. Many of the studies were also funded by commercial entities, with potential conflicts of interests. This was difficult to account for in our analyses. Overall, there is some clinical data to support the benefits of astaxanthin supplementation (in the range of 3 to 6 mg/d) on skin health, especially for photoaged skin" - See astaxanthin at Amazon.com.
  • Ultrasonographic Measurements of the Skin, Fat and Muscle in Vitamin D Deficiency - Int J Clin Pract. 2020 Feb 26 - "We imply that skin thicknesses (anterior forearm and tibia) and subcutaneous fat (trochanteric region) increase in subjects with low vitamin D levels" - See vitamin D at Amazon.com.
  • The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial - J Cosmet Dermatol. 2020 Jan 6 - "Oral hydrolyzed eggshell membrane ingestion was associated with a significant improvement in facial skin appearance in crow's feet in 4 weeks and skin tone in 8 weeks, with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth at 4, 8, and 12 weeks" - [Nutra USA] - See hydrolyzed eggshell membrane at Amazon.com.
  • Rapamycin may slow skin aging - Science Daily, 11/25/19 - "In the current Drexel-led study, 13 participants over age 40 applied rapamycin cream every 1-2 days to one hand and a placebo to the other hand for eight months. The researchers checked on subjects after two, four, six and eight months, including conducting a blood test and a biopsy at the six- or eight-month mark ... After eight months, the majority of the rapamycin hands showed increases in collagen protein, and statistically significant lower levels of p16 protein, a key marker of skin cell aging. Skin that has lower levels of p16 has fewer senescent cells, which are associated with skin wrinkles. Beyond cosmetic effects, higher levels of p16 can lead to dermal atrophy, a common condition in seniors, which is associated with fragile skin that tears easily, slow healing after cuts and increased risk of infection or complications after an injury"
  • Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress - Phytother Res. 2019 Nov 20 - "Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant-derived molecules possessing various degrees of estrogen-like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism" - See phytoestrogens at Amazon.com.
  • Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial - Altern Ther Health Med. 2019 Jun 13 - "The intervention consisted of twice daily oral administration of a supplement containing BioCell Collagen, a chicken sternal cartilage derived dietary ingredient composed of a naturally-occurring matrix of hydrolyzed collagen type-II (≥300 mg), chondroitin sulfate (≥100 mg), hyaluronic acid (≥50 mg) ... For the 113 participants completing the study, the dietary supplementation compared to a placebo: (1) significantly reduced facial lines and wrinkles (P = .019) and crow's feet lines and wrinkles (P = .05), (2) increased skin elasticity (P = .008) and cutaneous collagen content (P < .001) by 12%, (3) improved indicators associated with a more youthful skin appearance based on visual grading and wrinkle width (P = .046), and (4) decreased skin dryness and erythema. No difference existed between the supplement and the placebo for skin-surface water content or retention. The supplement was well tolerated, with no reported adverse reactions" - [Nutra USA] - See BioCell Collagen at Amazon.com, collagen UC-II at Amazon, hyaluronic acid at Amazon.com and chondroitin sulfate at Amazon.com.
  • Fighting against Skin Aging - Cell Transplant. 2018 May; 27(5): 729–73 - "Stem Cell Therapy ... Stem cell transplantation is a promising therapy for the treatment of skin aging. Adipose tissue transplantation could improve skin quality at the recipient site in addition to increasing skin volume75. Further experiments demonstrate that adipose-derived stem cells (ADSCs) contribute to the regeneration of skin during aging76,77. In recent clinical tests, autologous fat grafting rejuvenates aging skin and enhances the volume of periocular and perioral skin in recipients with an average age of 50 years78,79. Data show that ADSCs produce a series of growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor (TGF)-β1, TGF-β2, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), platelet-derived growth factor AA (PDGF-AA), and placental growth factor (PGF)80, reminding us that ADSCs may influence surrounding cutaneous cells through these secretions. It seemed that ADSC may also transdifferentiate into epithelial stem cells that express epithelial stem cell marker p63 after fat grafting81. This work provides clues into the understanding of how fat grafts may rejuvenate overlying skin." - Note: It seems like all these doctors have a Jihad against supplements. They make claims that it doesn’t help or makes things worse. Where are these studies they talk about? There are a few but the overwhelming amount of studies show the opposite (http://qualitycounts.com/fpwrinkles.htm and http://qualitycounts.com/fpskincare.html). It just gets my goat when they accuse others of making claims based on scientific studies when they make the opposite claims without evidence to back it up. My wife keeps commenting on how I don’t have any wrinkles and I’ve been taking supplements all my life.
    • Physicians and nurses use and recommend dietary supplements: report of a survey - Nutr J. 2009; 8: 29. - "The "Life...supplemented" Healthcare Professionals Impact Study (HCP Impact Study) found that 72% of physicians and 89% of nurses in this sample used dietary supplements regularly, occasionally, or seasonally ... Physicians and nurses are as likely as members of the general public to use dietary supplements, as shown by comparing the results of this survey with data from national health and nutrition surveys. Also, most physicians and nurses recommend supplements to their patients, whether or not the clinicians use dietary supplements themselves."
  • Antioxidant Properties of Ferulic Acid and Its Possible Application - Skin Pharmacol Physiol. 2018;31(6):332-336 - "Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care formulations as a photoprotective agent, delayer of skin photoaging processes, and brightening component. Nonetheless, its use is limited by its tendency to be rapidly oxidized" - See ferulic acid at Amazon.com.
  • Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin - Skin Pharmacol Physiol. 2018 Sep 10 - "Topically applied carnosine protects against the glycation induced by MG. Novel FC-CARN significantly reduced levels of AGEs in both epidermis and reticular dermis in human skin explants" -  Note:  I'm sticking with the oral form.  See carnosine products at Amazon.com.
  • Daily oral supplementation with collagen peptides combined with vitamins other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing - Nutr Res, Jun 9 2018 - "We hypothesized that daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants, and other active ingredients could improve skin texture and elasticity, and in addition have a protective effect on joint health. A double-blind, randomized, placebo-controlled clinical trial was conducted on 120 subjects who consumed either the test product or placebo on a daily basis for 90 days. Subjects consuming the test product had an overall significant increase in skin elasticity (+40%; P < .0001) when compared to placebo. Histological analysis of skin biopsies revealed positive changes in the skin architecture, with a reduction in solar elastosis and improvement in collagen fiber organization in the test product group. As reported in the self-perception questionnaires, these results were confirmed by the subjects' own perceptions in that participants agreed their skin was more hydrated and more elastic. In addition, the consumption of the test product reduced joint pain by −43% and improved joint mobility by +39%. Oral supplementation with collagen bioactive peptides combined with chondroitin, glucosamine, L-carnitine, vitamins, and minerals significantly improved the clinical parameters related to skin aging and joint health, and therefore, might be an effective solution to slow down the hallmarks of aging" - [Nutra USA] - See collagen supplements at Amazon.com.  The Active Gold Collagen used in this study is expensive.
  • Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study - Nutrients. 2018 Jun 26;10(7) - "Collagen-peptide supplementation could be an effective remedy to improve hydration, elasticity, and wrinkling in human skin. The aim of this study was to conduct a double-blind, randomized, placebo-controlled trial to clinically evaluate the effect on human skin hydration, wrinkling, and elasticity of Low-molecular-weight Collagen peptide (LMWCP) with a tripetide (Gly-X-Y) content >15% including 3% Gly-Pro-Hyp. Individuals (n = 64) were randomly assigned to receive either placebo or 1000 mg of LMWCP once daily for 12 weeks ... Compared with the placebo group, skin-hydration values were significantly higher in the LMWCP group after 6 weeks and 12 weeks. After 12 weeks in the LMWCP group, visual assessment score and three parameters of skin wrinkling were significantly improved compared with the placebo group. In case of skin elasticity, one parameter out of three was significantly improved in the LMWCP group from the baseline after 12 weeks, while, compared with the placebo group, two parameters out of three in the LMWCP group were higher with significance after 12 weeks" - [Nutra USA] - See collagen supplements at Amazon.com.
  • The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial - Nutrients. 2018 Jun 25;10(7) - "Twenty-three healthy Japanese participants were recruited to a 10-week double-blind placebo-controlled study. They were assigned to the astaxanthin group supplemented with a capsule containing 4 mg of astaxanthin or the placebo group. To assess the protective role of astaxanthin for UV-induced skin deterioration, we determined the minimal erythema dose (MED) and analyzed UV-induced changes of moisture and transepidermal water loss (TEWL) at baseline and after 9 weeks of supplementation ... The astaxanthin group showed increased MED compared with placebo. In addition, the astaxanthin group had a reduced loss of skin moisture in the irradiated area compared with placebo. Subjective skin conditions for &ldquo;improvement of rough skin&rdquo; and &ldquo;texture&rdquo; in non-irradiated areas were significantly improved by astaxanthin. Astaxanthin seems protective against UV-induced skin deterioration and helps maintain healthy skin in healthy people" - [Nutra USA] - See astaxanthin at Amazon.com.
  • Collagen supplements show early promise for skin and joints, but don’t stock up yet - Washington Post, 3/26/18 - "As we age, however, our bodies’ collagen production becomes less efficient, and the tissues that depend on it, such as our skin and joints, don’t get repaired the way they used to, which explains, at least in part, why our skin starts to sag and we have more aches and pains as the years tick by ... That’s where the supplements come in. Manufacturers have found a way to apply enzymes to gelatin to create protein chains called collagen hydrolysates. These small collagen chains (peptides) may be absorbed intact by the body to be used directly in the tissues. Predictably, there is a lot of hype and exaggerated claims around these supplements, but there is also a lot of promising, bona fide research pointing to benefits, particularly for more youthful-looking skin and help with joint pain ... A 2017 study in the Journal of Agriculture and Food Chemistry showed that collagen hydrolysates can be transferred through the bloodstream directly to the skin, which explains the probable pathway for these effects ... Although the science is building, it is relatively new and there is still a lot to learn, particularly in identifying what types of collagen peptides work with different conditions" - See collagen supplements at Amazon.com.
  • Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers - Nutrition Research, 10 Oct 17 - "All described RSSC changes correspond to a shift towards characteristics of skin associated with a younger age. The results confirm our hypothesis by demonstrating that continuous astaxanthin consumption produces a strong antioxidant effect resulting in facial skin rejuvenation which is especially pronounced in obese subjects" - [Nutra USA] - See BioAstin at Amazon.com.
  • Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period - Clin Cosmet Investig Dermatol. 2017 Jul 18 - "Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks ... During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group. After 8 weeks of ingestion, the HA 300 k group showed significantly diminished wrinkles compared with the placebo group. Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline" - [Nutra USA] - See hyaluronic acid at Amazon.com.
  • Protective effects of astaxanthin on skin deterioration - J Clin Biochem Nutr. 2017 Jul;61(1):33-39 - "Participants were orally administered either a 6 mg or 12 mg dose of astaxanthin or a placebo. Wrinkle parameters and skin moisture content significantly worsened in the placebo group after 16 weeks. However, significant changes did not occur in the astaxanthin groups. Interleukin-1α levels in the stratum corneum significantly increased in the placebo and low-dose groups but not in the high-dose group between weeks 0 and 16. This study was performed in Japan from August to December, when changing environmental factors, such as UV and dryness, exacerbate skin deterioration" - [Nutra USA] - See astaxanthin at Amazon.com.
  • Urtica thunbergiana prevents UVB-induced premature skin aging by regulating the transcription factor NFATc1: An in vitro and in vivo study - Journal of Functional Foods, September 2017 - "Urtica thunbergiana leaf extract (UT) ... Our data showed that UVB exposure decreased the level of phosphorylated NFATc1. One active component of UT, chlorogenic acid (CGA), regulated NFATc1 dephosphorylation to a similar extent as tacrolimus, a calcineurin inhibitor. Our results suggest that UT and its active component, CGA, have the potential to prevent UVB-induced premature skin aging by regulating NFATc1" - [Nutra USA] - See chlorogenic acid at Amazon.com.
  • Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice - PLoS One. 2017 Feb 7;12(2):e0171178 - "Our results indicate that dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA irradiation on filaggrin metabolism and desquamation in the epidermis and the extracellular matrix in the dermis" - [Nutra USA] - See BioAstin at Amazon.com.
  • Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, cross-over study - Br J Dermatol. 2016 Sep 23 - "We examined the capacity of lycopene rich tomato nutrient complex (TNC) and lutein, to protect against UVA/B- and UVA1 radiation at a molecular level ... Assuming the role of these genes as indicators of oxidative stress, photo-dermatoses and photo-aging these results might indicate that TNC and lutein could protect against solar radiation-induced health damage" - [Nutra USA] - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com and lutein at Amazon.com.
  • The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study - Biofactors. 2016 Aug 22 - "with 33 healthy subjects. Our objective was to investigate the effects of 12 weeks of daily supplementation with 50 and 150 mg of CoQ10 on skin parameters and condition. Study was conducted with a water-soluble form of CoQ10 with superior bioavailability (Q10Vital® ) ... We determined significantly reduced wrinkles and microrelief lines, and improved skin smoothness. Supplementation with CoQ10 did not significantly affect skin hydration and dermis thickness" - [Nutra USA] - See ubiquinol products at Amazon.com.
  • Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study - J Microbiol Biotechnol. 2015 Dec 28;25(12):2160-8 - "Participants took 1 × 10(10) CFU/day of HY7714 (probiotic group) or a placebo (placebo group) for 12 weeks. Skin hydration, wrinkles, skin gloss, and skin elasticity were measured every 4 weeks during the study period. There were significant increases in the skin water content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the probiotic group. Transepidermal water loss decreased significantly in both groups at weeks 4, 8, and 12 (p < 0.001 compared with baseline), and was suppressed to a greater extent in the face and forearm in the probiotic group at week 12. Volunteers in the probiotic group had a significant reduction in wrinkle depth at week 12, and skin gloss was also significantly improved by week 12. Finally, skin elasticity in the probiotic group improved by 13.17% (p < 0.05 vs. controls) after 4 weeks and by 21.73% (p < 0.01 vs. controls) after 12 weeks. These findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum HY7714 as a nutricosmetic agent" - [Nutra USA] - See Garden of Life Primal Defense ULTRA, 180 Capsules at Amazon.com.
  • Zeaxanthin-based dietary supplement and topical serum improve hydration and reduce wrinkle count in female subjects - J Cosmet Dermatol. 2016 Jun 17 - "Subjects were divided into three groups: two tests (skin formula 1 - oral product alone (ZO-1), skin formula 2- oral product with topical product (ZO-2 + ZT)), and one placebo control ... A statistically significant difference was observed between mean differences from baseline scores for total wrinkle count at week 4 for the combination active groups compared to placebo. A statistically significant difference from baseline scores for fine lines count was also observed at the week 4 visit compared to placebo for both active groups. Statistically significant differences from baseline scores for average wrinkles severity were seen for week 12 visit for both active groups compared to placebo" - [Nutra USA] - Note:  I couldn't find any serums with zeaxanthin at Amazon.  For facial serums, I've tried several.  Here's my pick: InstaNatural Vitamin C Skin Clearing Serum - Anti Aging Formula with Retinol & Hyaluronic Acid - Natural & Organic Wrinkle, Acne, Dark Spot, Fine Line & Hyperpigmentation Defying Facial Product
  • Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial aging signs in a randomized double-blind placebo-controlled clinical study - J Sci Food Agric. 2016 Feb 3 - "This study demonstrated that the collagen hydrolysate with a higher content of Pro-Hyp and Hyp-Gly, showed more improvement in facial skin condition, including facial skin moisture, elasticity, wrinkles and roughness" - [Nutra USA] - Note: Here's what I take: Peptan® Hydrolyzed Collagen Protein Powder - For Hair - Nails - Joint Pain Relief - Skin Care - Appetite Suppressant - Building Muscle - Bone Density - Osteopenia at Amazon.com.
  • Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols - Food Nutr Res. 2016 Jul 1;60:31871 - "We investigated the efficacy of a combination of rosemary (R. officinalis) and grapefruit (C. paradisi) in decreasing the individual susceptibility to UVR exposure (redness and lipoperoxides) and in improving skin wrinkledness and elasticity ... Treated subjects showed a decrease of the UVB- and UVA-induced skin alterations (decreased skin redness and lipoperoxides) and an improvement of skin wrinkledness and elasticity. No differences were found between the 100 and 250 mg extracts doses, indicating a plateau effect starting from 100 mg extracts dose. Some of the positive effects were noted as short as 2 weeks of product consumption ... The long-term oral intake of Nutroxsun™ can be considered to be a complementary nutrition strategy to avoid the negative effects of sun exposure" - [Nutra USA] - See Nutroxsun™ at Amazon.com.
  • Reducing the Harmful Effects of Infrared Radiation on the Skin Using Bicosomes Incorporating β-Carotene - Skin Pharmacol Physiol. 2016 Jul 6;29(4):169-177 - "infrared (IR) radiation ... free radicals (FRs) ... β-carotene (Bcb) ... EPR results showed an increase in the hydroxyl radical in the irradiated skin compared to the native skin. The skin collagen was degraded by IR exposure at high temperatures of approximately 65°C. The treatment with Bcb reduced the formation of FRs and kept the structure of collagen" - See carotenoids at Amazon.com.
  • Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence - Phytother Res. 2016 May 23 - "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health" - See curcumin products at Amazon.com.
  • Dietary proanthocyanidins inhibit UV radiation-induced skin tumor development through functional activation of the immune system - Mol Nutr Food Res. 2016 Mar 15 - "The incidence of skin cancer is equivalent to the incidence of malignancies in all other organs combined. The main risk factor for this disease is overexposure of the skin to solar ultraviolet (UV) radiation. UV irradiation induces inflammation, oxidative stress, DNA damage and suppression of the immune system in the skin, which together contribute to carcinogenesis. The use of dietary phytochemicals shows great promise as a complementary and alternative strategy for skin cancer prevention. Grape seed proanthocyanidins (GSPs) have been tested extensively for their anti-skin cancer effect using in vivo animal models ... These effects of GSPs could be useful in attenuation of the adverse effects of UV radiation and may have health benefits in humans" - See OPCs+95 at Amazon.com.
  • Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology - J Med Food. 2015 Dec;18(12):1340-8 - "specific bioactive collagen peptides (BCP) on the cellulite treatment of normal and overweight women. In total, 105 women aged 24-50 years with moderate cellulite ... 105 women aged 24-50 years with moderate cellulite were randomized to orally receive a daily dosage of 2.5 g BCP or a placebo over 6 months ... The results of the study demonstrated that a regular ingestion of BCP over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite. Based on the current data, it can be concluded that a long-term therapy with orally administered BCP leads to an improvement of cellulite and has a positive impact on skin health" - [Nutra USA] - Here's what I take: Peptan® Hydrolyzed Collagen Protein Powder - For Hair - Nails - Joint Pain Relief - Skin Care - Appetite Suppressant - Building Muscle - Bone Density - Osteopenia at Amazon.com.
  • Oral supplementation with cocoa extract reduces UVB-induced wrinkles in hairless mouse skin - J Invest Dermatol. 2016 Feb 5 - "Cacao beans contain various bioactive phytochemicals that could modify the pathogeneses of certain diseases. Here, we report that oral administration of cacao powder (CP) attenuates UVB-induced skin wrinkling by the regulation of genes involved in dermal matrix production and maintenance ... These results suggest that cacao extract may offer a protective effect against photoaging by inhibiting the breakdown of dermal matrix, which leads to an overall reduction in wrinkle formation" - [Nutra USA] - See Ghirardelli Chocolate Intense Dark Squares, Midnight Reverie, 4.12 oz., 86% Cacao (Pack of 4) at Amazon.com.
  • Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin - Skin Pharmacol Physiol. 2016 Jan 23 - "The formation of free radicals in human skin by solar ultraviolet radiation is considered to be the main reason for extrinsic skin aging. The antioxidants in human tissue represent an efficient protection system against the destructive action of these reactive free radicals ... The study included 5 groups of 15 volunteers each, who were treated for 2 months with antioxidant-containing or placebo tablets, creams or a combination of antioxidant-containing tablets and cream ... The verum cream had a positive influence on epidermal thickness, elasticity and skin moisture, but the verum tablets improved the epidermal thickness only. The combined application of verum tablets and creams led to a significant improvement of all investigated skin parameters, whereas the application of placebo tablets or cream did not influence any parameters" - See OZ Naturals- THE BEST Vitamin C Serum For Your Face Contains Clinical Strength 20% Vitamin C + Hyaluronic Acid Anti Wrinkle Anti Aging Serum For A Radiant & More Youthful Glow!, Protein Essentials Hydrolyzed Collagen Protein Powder with Peptan® (16oz) at Amazon.com and Sunkist Grower Select Blueberry Capsules, 500 mg, 90 Count Bottle.
  • Sugar Sag: Glycation and the Role of Diet in Aging Skin - Medscape, 12/23/15 - "First described in the context of diabetes, advanced glycation end products (AGEs) are formed through a type of non-enzymatic reaction called glycation. Increased accumulation of AGEs in human tissue has now been associated with end stage renal disease, chronic obstructive pulmonary disease, and, recently, skin aging. Characteristic findings of aging skin, including decreased resistance to mechanical stress, impaired wound healing, and distorted dermal vasculature, can be in part attributable to glycation. Multiple factors mediate cutaneous senescence, and these factors are generally characterized as endogenous (e.g., telomere shortening) or exogenous (e.g., ultraviolet radiation exposure). Interestingly, AGEs exert their pathophysiological effects from both endogenous and exogenous routes. The former entails the consumption of sugar in the diet, which then covalently binds an electron from a donor molecule to form an AGE. The latter process mostly refers to the formation of AGEs through cooking. Recent studies have revealed that certain methods of food preparation (i.e., grilling, frying, and roasting) produce much higher levels of AGEs than water-based cooking methods such as boiling and steaming"
  • Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial - J Nutr. 2015 Nov 18 - "The consumption of dietary antioxidants is considered to be a good strategy against photo-aging ... All participants were moderately photo-aged Korean women with visible facial wrinkles (age range: 43-86 y). Participants were randomly assigned to receive a placebo beverage or cocoa beverage that contained 320 mg total cocoa flavanols/d ... In moderately photo-aged women, regular cocoa flavanol consumption had positive effects on facial wrinkles and elasticity. Cocoa flavanol supplementation may contribute to the prevention of the progression of photo-aging"
  • French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence - Skin Pharmacol Physiol. 2015 Oct 23 - "the existing data provide compelling evidence that Pycnogenol® intake does not only provide photoprotection, but may be used to (i) reduce hyperpigmentation of human skin and (ii) improve skin barrier function and extracellular matrix homeostasis" - See Pycnogenol at Amazon.com.
  • The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials - J Cosmet Dermatol. 2015 Sep 12 - "Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration ... Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects" - [Nutra USA] - See Protein Essentials Hydrolyzed Collagen Protein Powder with Peptan® (16oz) at Amazon.com. It's the Rousselot Peptan collagen brand talked about in the Nutra USA article.  See their websites: Rousselot Peptan collagen website and Protein Essentials.
  • Safety and Efficacy of Oral Polypodium leucotomos Extract in Healthy Adult Subjects - J Clin Aesthet Dermatol 2015 Feb - "Polypodium leucotomos extract 240mg taken twice daily for 60 days was a safe and effective means for reducing the damaging effects of ultraviolet radiation. Based on the excellent safety profile of Polypodium leucotomos, additional studies using higher doses may be warranted" - See Polypodium leucotomos at Amazon.com.
  • Lifestyle and Youthful Looks - Medscape, 7/7/14 - "In Dutch men, smoking, having skin that went red in the sun, being outside in the sun most of the summer, sunbed use, wearing false teeth and not flossing teeth were all significantly associated (P < 0·05) with a total 9.3-year higher perceived facial age in a multivariate model adjusting for chronological age. In Dutch women, smoking, sunbathing, sunbed use, few remaining teeth and a low body mass index (BMI) were associated with a total 10.9-year higher perceived facial age. In English women, cleaning teeth only once a day, wearing false teeth, irregular skin moisturization and having skin that went red in the sun were associated with a total 9.1-year higher perceived facial age. Smoking and sunbed use were associated more strongly with wrinkling in women than in men. BMI, sun exposure and skincare were associated predominantly with perceived facial age via wrinkling, whereas oral care was associated via other facial features"
  • Younger Skin Through Exercise - NYTimes.com, 4/16/14 - "The scientists biopsied skin samples from each volunteer and examined them microscopically. When compared strictly by age, the skin samples overall aligned with what would be expected. Older volunteers generally had thicker outer layers of skin and significantly thinner inner layers ... But those results shifted noticeably when the researchers further subdivided their samples by exercise habits. They found that after age 40, the men and women who exercised frequently had markedly thinner, healthier stratum corneums and thicker dermis layers in their skin. Their skin was much closer in composition to that of the 20- and 30-year-olds than to that of others of their age, even if they were past age 65 ... the researchers next set a group of sedentary volunteers to exercising ... I don’t want to over-hype the results, but, really, it was pretty remarkable to see ... Under a microscope, the volunteers’ skin “looked like that of a much younger person, and all that they had done differently was exercise"
  • Five Foods for Healthier Skin - ABC News, 3/31/14 - "The main factor responsible for aging, wrinkly skin is ultraviolet radiation, or skin photoaging. A French study on 1,264 women and 1,655 men suggests that the monounsaturated fatty acid in olive oil is protective against severe photoaging. Photodamage, including blotchy pigmentation, wrinkling and skin sagging, is mainly caused by the production of reactive oxygen species (ROS) in response to sun exposure. This study suggests that olive oil in the diet increases the ability of the skin to resist damage caused by UV radiation"
  • New and improved laser and light treatments take aim at cellulite, fat, tattoos, wrinkles and sagging skin - Science Daily, 3/21/14 - "Overall, the fractionated CO2 laser is safer, has fewer side effects, and is better tolerated than the original CO2 laser while still producing gold-standard results ... Fractionated CO2 laser is now the preferred treatment for wrinkles and acne scars"
  • Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome - Lipids Health Dis. 2014 Feb 11;13(1):31 - "spontaneously hypertensive obese rats (SHROB) were fed for 13 weeks with 3 different suplemmentation of fish oil containing EPA and DHA ratios (1:1, 2:1 and 1:2, respectively) ... EPA:DHA 1:1 treatment tended to improve the density and the wrinkling of elastic layers in SHROB rats. Only Wistar rats fed with EPA:DHA 1:1 treatment did not show mast cells in adipose tissue and has less kidney atrophy. In both strains EPA:DHA 1:1 treatment improved inflammation related parameters in liver and kidney" - See fish oil supplements at Amazon.com and DHA products at Amazon.com.  Most fish oil supplements have more EPA than DHA so you'd probably have to add the DHA to get the 1:1 ratio.
  • Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis - Skin Pharmacol Physiol. 2013 Dec 24;27(3):113-119 - "In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group ... The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected" - See Verisol at Amazon.com.
  • Fresh faced: Looking younger for longer - Science Daily, 1/10/14 - "While UVB radiation easily causes sunburn, UVA radiation penetrates deeper, damaging our DNA by generating free radicals which degrades the collagen that gives skin its elastic quality ... the most potent anti-oxidants were those that targeted the batteries of the skin cells, known as the mitochondria. They compared these mitochondrial-targeted anti-oxidants to other non-specific antioxidants such as resveratrol, found in red wine, and curcumin found in curries, that target the entire cell. They found that the most potent mitochondrial targeted anti-oxidant was Tiron which provided 100%, protection of the skin cell against UVA sun damage and the release of damaging enzymes causing stress-induced damage ... Tiron is not a naturally occurring compound and has not yet been tested for toxicity in humans although there have been a few studies on rats ... Antioxidants in our diets from green tea, resveratrol which is found in red wine, turmeric which is used in curries and lycopene found in tomatoes, as well as some components in cosmetic creams, are known to neutralise this damage within the cells. They can slow down the damage and the rate of aging and potentially lower the rate of other sun-induced skin lesions ... Resveratrol, the antioxidant found in red wine, was found to protect against 22% of both the ultraviolet A radiation and stress-induced damage. NAC, a frequently used laboratory-based anti-oxidant, offered 20% protection against oxidative stress and 8% against UVA and curcumin offered 16% protection against oxidative stress and 8% against UVA" - See resveratrol products at Amazon.com, n-acetyl cysteine at Amazon.com and curcumin products at Amazon.com.
  • Anti-aging strategies can improve more than looks - Science Daily, 11/1/13 - "The No. 1 way people can prevent photoaging is wearing a 30-plus SPF sunscreen -- one that contains zinc oxide -- every day ... Using an over-the-counter cream with retinol, which is a vitamin A derivative, can decrease the risk of skin cancer and improve skin pigmentation and abnormalities, as well as increase collagen content to help with lines and wrinkles ... Fraxel laser resurfacing is an excellent way to improve wrinkles, pigmentation and abnormalities" - See retinol products at Amazon.
  • Sleep deprivation linked to aging skin, study suggests - Science Daily, 7/23/13 - "Our study is the first to conclusively demonstrate that inadequate sleep is correlated with reduced skin health and accelerates skin aging. Sleep deprived women show signs of premature skin aging and a decrease in their skin's ability to recover after sun exposure ... The study involved 60 pre-menopausal women between the ages of 30 and 49, with half of participants falling into the poor quality sleep category ... Using the SCINEXA skin aging scoring system, poor quality sleepers showed increased signs of intrinsic skin aging including fine lines, uneven pigmentation and slackening of skin and reduced elasticity. In this system, a higher score means a more aged appearance. The average score in the good quality sleepers was 2.2 versus 4.4 in poor quality sleepers"
  • Lutein, Zeaxanthin, and Skin Health - Medscape, 6/7/13 - "Results from cell culture and animal studies showing that lutein and zeaxanthin exhibit positive skin health benefits have considerable merit and suggest an avenue by which these carotenoids may function. The results from one human study demonstrate that orally administered lutein and zeaxanthin can inhibit lipid peroxidation on the surface of the skin and help bolster the skin's photoprotective activity, potentially protecting the skin from exposure to light, particularly UV light. Since the typical diet of people in the United States is about 2 mg of lutein per day, due to the ingestion of foods such as green leafy vegetables that contain the highest levels of diet-derived lutein and zeaxanthin,[15] it may be considered advisable to increase the daily intake of lutein and zeaxanthin for optimal skin health and photoprotection" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • Silibinin, found in milk thistle, protects against UV-induced skin cancer - Science Daily, 1/30/13 - "A pair of University of Colorado Cancer Center studies published this month show that the milk thistle extract, silibinin, kills skin cells mutated by UVA radiation and protects against damage by UVB radiation -- thus protecting against UV-induced skin cancer and photo-aging ... When you have a cell affected by UV radiation, you either want to repair it or kill it so that it cannot go on to cause cancer. We show that silibinin does both" - See silymarin at Amazon.com.
  • Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid - Br J Nutr. 2013 Jan 28:1-10 - "sixteen healthy human subjects (phototype I/II) were given low-dose GTC (540 mg) with vitamin C (50 mg) daily for 12 weeks. Pre- and post-supplementation, the buttock skin was exposed to UVR and the resultant erythema quantified. Skin blister fluid and biopsies were taken from the unexposed and the UVR-exposed skin 24 h after a pro-inflammatory UVR challenge (three minimal erythema doses) ... GTC intake results in the incorporation of catechin metabolites into human skin associated with abrogated UVR-induced 12-HETE; this may contribute to protection against sunburn inflammation and potentially longer-term UVR-mediated damage" - See green tea extract at Amazon.com.
  • Do Fruits and Veggies Make You More Attractive? - WebMD, 3/7/12 - "changes in the redness and yellowness of skin in white people may be linked to the number of servings of fruit and vegetables they eat on a daily basis. These antioxidant-rich foods, which are loaded with plant-based pigments, seem to affect skin tone ... They suggest it's the carotenoids -- the red, yellow, and orange pigments in fruits and vegetables -- that play an important role in skin tone. Foods such as carrots, sweet potatoes, squash, and apricots are rich in beta-carotene, as are some dark green vegetables, including spinach and kale ... Another carotenoid is lycopene, which is found in tomatoes and pink grapefruits" - See Jarrow Formulas, CarotenALL at Amazon.com and Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Study unlocks Pycnogenol’s skin health mechanism - Nutra USA, 1/26/12 - "Daily supplements of an extract from French maritime pine bark may boost skin elasticity by 25% and skin hydration by 8% ... the pine bark extract was also associated with a 3% reduction in skin wrinkles" - [Abstract] - See Pycnogenol at Amazon.com.  Some say grape seed extract is the same thing without the patent mark-up.  See grape seed extract at Amazon.com.
  • Antioxidant Micronutrients Improve Intrinsic and UV-Induced Apoptosis of Human Lymphocytes Particularly in Elderly People - J Nutr Health Aging. 2011;15(10):912-917 - "The study was a 2 months, double-blind, randomized trial. Three age groups were studied: children, young adults and elderly people. A total of 274 healthy subjects were allocated to a group supplemented with moderate amounts of retinol, β-carotene, α-tocopherol, ascorbic acid and selenium or placebo ... Young and elderly people have a higher intrinsic apoptosis than children, which was improved by antioxidant supplementation. UV-induced damage was attenuated by the supplementation in all three age groups"
  • Juice concentrates may boost skin-from-within - Nutra USA, 9/14/11 - "Skin hydration improved by 9% while skin thickness increased by 6% following 12 weeks of supplementation with a micronutrient-dense concentrate of a range of fruit and vegetables including cherry, apple, broccoli, cranberry, orange, pineapple, spinach, and tomato ... skin microcirculation also improved by almost 40% following supplementation with the juice concentrate, which could boost the supply of nutrients and oxygen to the skin and thereby boosting health" - [Abstract] - See Garden of Life, Radical Fruits Antioxidant Complex, 60 Caplets.  I'll save you the multi-level-marketing Juice Plus mark-up.
  • Which Foods Can Help Your Skin Look Better - CBS Chicago, 7/14/11 - "Experts say that what you eat has a big effect on how you look ... people who switched to a hypoglycemic – or low sugar – diet for three months reduced their pimples by 20 percent ... So what should we eat to prevent or even get rid of wrinkles? ... What you want to do is build up the collagen and there’s certain collagen builders, such as Vitamin C and Vitamin E ... To avoid dry, flaky skin or eczema, increase your omega 3s ... There’s less scientific proof about cellulite, but many nutritionists also feel you can reduce the appearance of those unsightly bulges by eating dark red and purple foods, which help rid the body of toxins – things like cranberry juice, blueberries, cherries and radicchio lettuce ... If you’re looking for a cure-all for nearly any skin problem, it’s extra virgin olive oil. It helps reduce inflammation, and can help everything from psoriasis to eczema to acne .. dairy, even skim-milk, seems to make nearly every skin problem worse"
  • Green Tea Polyphenols Provide Photoprotection, Increase Microcirculation, and Modulate Skin Properties of Women - J Nutr. 2011 Apr 27 - "Dietary constituents including polyphenols and carotenoids contribute to endogenous photoprotection and modulate skin characteristics related to structure and function of the tissue. Animal and in-vitro studies indicate that green tea polyphenols affect skin properties. In a 12-wk, double-blind, placebo-controlled study, 60 female volunteers were randomized to an intervention or control group. Participants consumed either a beverage with green tea polyphenols providing 1402 mg total catechins/d or a control beverage. Skin photoprotection, structure, and function were measured at baseline (wk 0), wk 6, and wk 12. Following exposure of the skin areas to 1.25 minimal erythemal dose of radiation from a solar simulator, UV-induced erythema decreased significantly in the intervention group by 16 and 25% after 6 and 12 wk, respectively. Skin structural characteristics that were positively affected included elasticity, roughness, scaling, density, and water homeostasis. Intake of the green tea polyphenol beverage for 12 wk increased blood flow and oxygen delivery to the skin. Likewise, in a separate, randomized, double-blind, single-dose (0.5, 1.0, and 2.0 g) study of green tea polyphenols, blood flow was maximized at 30 min after ingestion. In summary, green tea polyphenols delivered in a beverage were shown to protect skin against harmful UV radiation and helped to improve overall skin quality of women" - See green tea extract at Amazon.com.
  • Sugar and Your Skin - ABC News, 11/30/10 - It's a video.  He talks about glycation, fish oil, sugar, etc.  Things I've had in my newsletters for years.  See those pages.
  • Association of facial skin aging and vitamin D levels in middle-aged white women - Cancer Causes Control. 2010 Sep 30 - "Adjusting for age and season of blood collection, women with lower photodamage scores were associated with a 5-fold increased odds of being vitamin D insufficient (OR 5.0, 95% CI: 1.1, 23). Low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling were also significantly associated with vitamin D insufficiency. Our results suggest an association between skin aging and 25(OH)D levels" - See vitamin D at Amazon.com.
  • Pomegranate compounds show skin health potential - Nutra USA, 8/10/10 - "ellagic acid may prevent the degradation of collagen in human skin cells, which would maintain skin structure and slow the formation of wrinkles ... Topical or dietary interventions with berries and pomegranate rich in ellagic acid and ellagitannins are promising strategies in curtailing skin wrinkling and cutaneous inflammation associated with chronic UV exposure leading to photoageing" - [Abstract] - See pomegranate at Amazon.com.
  • Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation - Exp Dermatol. 2010 Aug;19(8):e182-90 - "Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases ... These results demonstrate that ellagic acid prevented collagen destruction and inflammatory responses caused by UV-B. Therefore, dietary and pharmacological interventions with berries rich in ellagic acid may be promising treatment strategies interrupting skin wrinkle and inflammation associated with chronic UV exposure leading to photoageing" - See pomegranate at Amazon.com.
  • Clinical evidence of skin benefits of a dietary supplement containing probiotic and carotenoids on UV- induced damage - Br J Dermatol. 2010 Jun 9 - "Lactobacillus johnsonii (La1) ... dietary supplement (DS) combining La1 and nutritional doses of carotenoids ... A 10 week DS intake prevented the UV-DL induced decrease in Langerhans cell density and the increase in Factor XIIIa+ type I dermal dendrocytes while it reduced dermal inflammatory cells. Clinical and instrumental MED rose by 20% and 19% respectively, and skin colour was intensified, as shown by the increase in DeltaE parameter. The efficacy of DS was confirmed by dermatologists and subjects in real conditions of use. Conclusion: Nutritional supplementation combining a specific probiotic (la1) and nutritional doses of carotenoids reduced early UV-induced skin damage caused by simulated or natural sun exposure in a large panel of subjects (n=139). Altogether, these results support the use of this nutritional supplement for a global approach in photoprotection, in combination with a sunscreen" - See probiotics at Amazon.com and Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • Turmeric Cream Decreases Signs of Aging - Medscape, 3/16/10 - "A new moisturizing cream containing turmeric extract, an ingredient found in curry, significantly improves the appearance of facial spots, fine lines, and wrinkles, according to results from 2 split-face studies (1 with an all-white and 1 with an all-Asian patient population) presented here at the American Academy of Dermatology 68th Annual Meeting" - See curcumin products at Amazon.com.
  • Association of dietary fat, vegetables and antioxidant micronutrients with skin ageing in Japanese women - Br J Nutr. 2010 Jan 20:1-6 - "The extent of facial wrinkles in the crow's-foot area was determined by observation using the Daniell scale. Each subject's usual diet was determined with the use of a validated FFQ. After controlling for covariates including age, smoking status, BMI and lifetime sun exposure, the results showed that higher intakes of total fat, saturated fat and monounsaturated fat were significantly associated with increased skin elasticity. A higher intake of green and yellow vegetables was significantly associated with a decreased Daniell wrinkling score. Intake of saturated fat was significantly inversely associated with the Daniell wrinkling score after additional adjustment for green and yellow vegetable intake"
  • Microdermabrasion May Rejuvenate Aging Skin - WebMD, 10/20/09
  • New Role Of Vitamin C In Skin Protection; Relevance To The Cosmetics Industry - Science Daily, 9/8/09 - "a form of Vitamin C helped to promote wound healing and also helped protect the DNA damage of skin cells ... Previously, the group has published evidence that DNA repair is upregulated in people consuming vitamin C supplements ... The results demonstrated that vitamin C may improve wound healing by stimulating quiescent fibroblasts to divide and by promoting their migration into the wounded area. Vitamin C could also protect the skin by increasing the capacity of fibroblasts to repair potentially mutagenic DNA lesions ... Free radicals are associated with premature skin aging, and antioxidants, such as vitamin C, are known to counter these highly damaging compounds. This new evidence suggest that, in addition to ‘mopping up’ free radicals, vitamin C can help remove the DNA damage they form, if they get past the cell’s defences"
  • Dysport Deemed Safe, Effective Anti-wrinkle Treatment, Plastic Surgeons Say - Science Daily, 8/3/09
  • Hydrolysed collagen may boost beauty from within: Rousselot studies - Nutra USA, 5/7/09 - "According to the company, women receiving the collagen supplement experienced a 28 per cent improvement in the skin hydration levels, compared to placebo, with 91 per cent of these women reporting increased skin hydration levels after eight weeks ... Furthermore, the number of micro-relief furrows and deep wrinkles decreased by 26 and 30 per cent, compared with the placebo group" - See collagen products at iHerb.
  • Anti-ageing Cosmetic Reduced Wrinkles In Clinical Trial - Science Daily, 4/28/09 - "the cosmetic, No7 Protect & Perfect Intense Beauty Serum, could improve some of these clinical features ... 70% of individuals using the beauty product had significantly fewer wrinkles after 12 months of daily use compared to volunteers using a placebo" - Note:  The best I could figure is that it is only sold in England.
  • Antioxidant Found In Berries, Other Foods Prevents UV Skin Damage That Leads To Wrinkles - Science Daily, 4/21/09 - "Using a topical application of the antioxidant ellagic acid, researchers at Hallym University in the Republic of Korea markedly prevented collagen destruction and inflammatory response – major causes of wrinkles -- in both human skin cells and the sensitive skin of hairless mice following continuing exposure to UV-B, the sun's skin-damaging ultraviolet radioactive rays ... Ellagic acid is an antioxidant found in numerous fruits, vegetables and nuts, especially raspberries, strawberries, cranberries and pomegranates ... the results demonstrate that ellagic acid works to prevent wrinkle formation and photo-aging caused by UV destruction of collagen and inflammatory response"
  • Better skin from the beauty aisle - MSNBC, 1/18/09
  • What Ages Us Most? It's Called Life - Time Magazine, 2/10/09 - "The bottom line is that if you care mostly about a young-looking face, don't smoke, don't go into the sun without protection, and try not to get into a bad relationship that will make you depressed"
  • Three Treatments Shown to Work Against Wrinkles - NYTimes.com, 8/18/08 - "A recent review in The Archives of Dermatology concludes that three anti-aging treatments are proven clinically effective: the topical application of retinol; carbon dioxide laser resurfacing; and injection of hyaluronic acid, a moisture-retaining acid that occurs naturally in the skin" - drugstore.com has retinol.  Also, see hyaluronic acid at Amazon.com.
  • Study supports lycopene protecting skin from within - Nutra USA, 4/29/08 - "Consuming lycopene-rich tomato paste may protect against sunburn and sun-induced skin ageing ... Skin samples taken from the subjects indicated that the tomato paste-supplemented individuals had higher skin levels of pro-collagen, a molecule which gives the skin its structure and loss of which leads to skin ageing and lack of elasticity" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Vitamin C can keep you healthy, looking younger - CNN.com, 2/27/08 - "people who ate foods rich in vitamin C had fewer wrinkles and less age-related dry skin than those whose diets contained only small amounts of the vitamin. C helps form collagen, which smooths fine lines and wrinkles ... Farris recommends La Roche-Posay Active C facial moisturizer or SkinCeuticals C E Ferulic topical antioxidant treatment ... taking more than 700 milligrams of C supplements daily reduced the risk of cardiovascular disease by 25 percent. And a recent study from Harvard University researchers hints that women who take a combo of 500 milligrams of vitamin C daily and 600 IU of vitamin E (another antioxidant) can cut their risk of stroke by 30 percent ... Pairing vitamins C and E is smart for another reason: It may lessen your Alzheimer's risks by as much as 64 percent ..." - See La Roche-Posay Active C facial moisturizer or SkinCeuticals C E Ferulic at Amazon.com and vitamin C products at Amazon.com.
  • What To Eat For Glowing Healthy Skin - Science Daily, 11/14/07 - "the antioxidants in vitamins C and E can protect the skin from sun damage and help reduce damage in skin cells caused by harmful free radicals, which contribute to aging skin. Similarly, we have long known that the B vitamin biotin is responsible for forming the basis of skin, hair and nail cells, and vitamin A – found in many fruits and vegetables – maintains and repairs skin tissue"
  • Vitamin K shows potential in the fight against wrinkles - Nutra USA, 10/19/07 - [Abstract] - "Recent studies have linked vitamin K to the elasticity of skin in patients suffering from pseudoxanthoma elasticum (PXE), an inherited condition resulting in severe wrinkling of the skin on the face and body" - See vitamin K at Amazon.com.
  • Wrinkle creams: Your guide to younger looking skin - CNN - "Coenzyme Q10 is a nutrient that helps regulate energy production in cells. Some studies have shown reduction in fine wrinkles around the eyes with no side effects"
  • Vitamin C May Slow Skin Wrinkling - WebMD, 10/8/07 - "After adjusting for other factors likely to influence skin aging, such as sun exposure and smoking, vitamin C and linoleic acid were independently associated with skin aging ... After digestion, linoleic acid is converted to DHA and EPA -- two fatty acids" - See vitamin C products at Amazon.com and Mega Twin EPA at Amazon.com. - Note:  I'm not sure that is correct.  Linoleic acid is an omega-6, which is not converted to DHA and EPA.  Most Americans get about ten time too much omega-6 already.
  • Dietary nutrient intakes and skin-aging appearance among middle-aged American women - Am J Clin Nutr. 2007 Oct;86(4):1225-1231 - "Higher intakes of vitamin C and linoleic acid and lower intakes of fats and carbohydrates are associated with better skin-aging appearance. Promoting healthy dietary behaviors may have additional benefit for skin appearance in addition to other health outcomes in the population"
  • Antioxidant To Retard Wrinkles Discovered - Science Daily, 8/30/07 - "Antioxidants operate against free radicals which cause a breakdown of many tissues in the body, including the skin. When found in small quantities in the body, free radicals are not harmful and are even involved in various physical processes. When there is an excess of free radicals, however, as occurs during normal aging or as a result of excessive exposure to ultra-violet radiation from the sun, the result, among other things, is a breakdown of the collagen and elastin fibers in the skin. When this happens, there is a loss of skin elasticity and the formation of wrinkles ... A problem with many of the commercial antioxidants found today in the market that are said to retard the aging process is that they oxidize quickly and therefore their efficiency declines with time"
  • Vitamin A (Retinol) Effaces Wrinkles in Naturally Aged Skin - Medscape, 5/39/07 - "Fine wrinkling improved with retinol treatment, whereas there was little change in the control group. This benefit of retinol was evident at 4 weeks of treatment and continued through week 24" - See retinol products at drugstore.comicon.
  • Vitamin A Helps Reduce Wrinkles Associated With Natural Skin Aging - Science Daily, 5/21/07 - "Applying vitamin A to the skin appears to improve the wrinkles associated with natural aging and may help to promote the production of skin-building compounds ... Researchers applied a lotion containing 0.4 percent retinol"
  • On The Cover: Scientifically Advanced Skin Care - Life Extension Magazine, 1/07
  • Lutein skin health study elicits excited response at conference - Nutra USA, 9/13/06 - "the oral lutein supplement was seen to increase skin hydration by 38 per cent, skin elasticity by 8 per cent, and the level of superficial lipids by 33 per cent (after adjustments for placebo)" - See lutein at Amazon.com.
  • Eat Right To Keep Healthy Skin - CBS 2 Chicago, 4/30/05 - "Clinical studies have found that eating a diet rich in fruits, vegetables, whole grains, legumes and omega-3 fatty acids can help skin retain its healthy glow and look youthful ... foods for healthy skin include those rich in lycopene. That's a pigment that gives many fruits and vegetables their red color. It's a proven antioxidant, and antioxidants are important because they reduce the risk of several types of cancer and they prevent the formation of harmful byproducts of metabolism called free radicals"
  • A Partial Reversal of Skin Aging - Life Extension Magazine, 4/04
  • Fighting Back Against Skin Aging - Life Extension Magazine, 8/03
  • Risky Wrinkle Removers? - Dr. Weil, 5/16/03
  • Green Tea Gives Skin Healthy Glow - HealthDay, 5/15/03 - "Green tea contains compounds called polyphenols, which help eliminate free radicals. These free radicals can cause cancer by altering DNA. Polyphenols also protect healthy cells while promoting the death of cancer cells ... Cells that migrate toward the surface of the skin normally live about 28 days, and by day 20 they basically sit on the upper layer of the skin getting ready to die. But EGCG reactivates them ... EGCG may offer potential benefits for skin conditions including psoriasis, rosacea, wrinkles and wounds" - See iHerb green tea extracts.  My favorite is Jarrow green tea at iHerb.
  • Vitamin K and niacin good for complexion, experts say - HealthDay, 3/26/03 - "Vitamin K was found to be successful in treating dark circles under the eyes. It's also been found effective for treating bruising on the face following dermatologic procedures such as laser treatment for spider veins ... Niacin shows promise as an over-the-counter ingredient in anti-aging products"
  • Combating Skin Aging - Life Extension Magazine, 1/03 - "Factors that induce skin damage involve the excessive production of free radicals. Protecting against these free radical insults is a proven way to slow the effects of aging ... the vitamin C-treated side of the face showed a statistically significant 71% combined score improvement ... The oral ingestion of fish, flax or perilla oil provides abundant quantities of the omega-3 fatty acids that are so beneficial to the health and appearance of the skin ... DMAE may be the first topical agent that can help firm sagging skin" - See Drugstore.com vitamin C serumsicon and glycolic acidicon products.
  • The Anti-Aging Effects of Carnosine - Life Extension Magazine, 1/03 - "Carnosine quenches the most destructive protein-oxidizing agent (the hydroxyl radical). One study showed carnosine was the only antioxidant to significantly protect cellular chromosomes from oxidative damage.2 Antioxidants cannot completely protect proteins. Nature's second line of defense is to repair or remove damaged proteins.3 This is where carnosine demonstrates its most profound anti-aging effect ... Studies show that carnosine is effective against cross-linking and the formation of advanced glycation end products (AGE).6,7 Glycated proteins produce 50-fold more free radicals than nonglycated proteins and carnosine may be the most effective anti-glycating agent known" - See iHerb carnosine products.
  • Preparing Your Own Skin Potions? - Dr. Weil, 7/30/02
  • Few Vitamins Effectively Prevent or Reverse Skin Damage - Medscape, 3/02 - "Despite advertising claims, almost all available topical formulations contain very low concentrations of antioxidants that are not well absorbed by the skin ... There are 3 antioxidants that have been proven to decrease the effect of the sun on the skin and actually prevent further damage: selenium, vitamin E, and vitamin C ... Recent animal studies have found that when selenium is taken orally or through the skin in the form of L-selenomethionine, it provided protection against both everyday and excessive UV damage ... New laboratory studies suggest vitamin E helps inactivate free radicals, making them less likely to cause damage ... Even minimal UV exposure can decrease the vitamin C levels in the skin by 30%, while exposure from the ozone of city pollution can decrease the level by 55%"

Other News:

  • Fluorouracil - Wikipedia, the free encyclopedia - "The chemotherapy agent 5-FU, which has been used against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase inhibitor ... Some of its principal uses are in colorectal cancer, and pancreatic cancer"

    • Note: A dermatologist prescribed the fluorouracil 5% topical cream (40 grams) for one spot of actinic keratosis on my cheek that the nitrogen spray wouldn’t cure but said to put it on my entire face twice daily for two weeks.  See the video below which someone else made.  It looks really bad from about day 9 put heals at about day 21.  After it heals, it gives you significantly younger looking skin.  I doubt is laser treatment works that well or looks that natural.  Offshore RX sells 10 mg tubes (you’d need four tubes) but I wouldn’t try it without a doctor’s supervision.  It’s serious stuff and it burns really bad from about day 10 until about day 17.
    • Fluorouracil Cream 5% - YouTube
  • Old skins cells reprogrammed to regain youthful function - Science Daily, 4/8/22 - "Fibroblasts produce collagen, a molecule found in bones, skin tendons and ligaments, helping provide structure to tissues and heal wounds. The rejuvenated fibroblasts produced more collagen proteins compared to control cells that did not undergo the reprogramming process. Fibroblasts also move into areas that need repairing. Researchers tested the partially rejuvenated cells by creating an artificial cut in a layer of cells in a dish. They found that their treated fibroblasts moved into the gap faster than older cells. This is a promising sign that one day this research could eventually be used to create cells that are better at healing wounds"
  • After Huge Weight Loss, Sagging Skin Remains - nbcnews.com, 3/7/14 - "To get rid of the loose skin, exercise helps, a little ... The most effective way to remove the excess skin is through cosmetic surgery, in one or more of an array of procedures known as body contouring"
  • Under Laser Procedure, Face Renews Itself With Younger-Looking Skin  - CBS Chicago, 12/24/12 - "A newer Erbium laser helps patients heal more quickly, with less down time — about three to four weeks instead of three months ... The procedure costs anywhere from $1,200 to $4,000. The Erbium laser can also be used for burns and severe acne, laser hair removal and for full-face laser re-surfacing"
  • Why being tired makes us look ugly - nbcnews.com, 12/19/12 - "Stress causes a drop in the skin’s ability to protect itself ... And stress can also lead to less melanin, causing that jaundiced, haggard look. Melanin pigments the skin, giving humans their complexion ... Not sleeping causes us to accumulate water under our eyes, giving us that extra "baggage" ... What you get from stress is the wrinkles of aging .. Stress causes you to age ... stress not only causes wrinkles on the face but wrinkles in your arteries, as well, which can cause serious problems at an earlier age ... Your cells are biologically 10 to 15 years older … if you are chronically stressed ... If you are 45, the cells signal as if they are 60 years old"
  • New anti-aging treatments make it easier to turn back the clock - Science Daily, 2/7/12 - "The newest filler introduced and approved by the U.S. Food and Drug Administration (FDA) for facial rejuvenation is calcium hydroxylapatite. This filler restores facial volume and promotes collagen production, lasting for up to a year in most cases. This calcium hydroxylapatite filler is thicker than the hyaluronic acid fillers currently available, requiring less product to be used. However, Dr. Kim noted that the thickness of calcium hydroxylapatite also is associated with slightly higher adverse effects than hyaluronic acid fillers ... Dr. Kim recommends that patients look for ingredients such as retinoids (chemical compounds derived from vitamin A), peptides (smaller proteins that stimulate collagen production), and growth factors (compounds that act as chemical messengers between cells and play a role in collagen production). Added into inexpensive skin care products, these have the ability to repair skin damage from sun exposure or other toxic chemicals and, in some cases, stimulate collagen production"
  • FDA Approves Gel Dermal Filler for Facial Wrinkles - Medscape, 11/21/11 - "The product combines a cohesive polydensified matrix technology with a hyaluronic acid base that attracts water to the injected area to fill and plump the wrinkle in natural way ... Potential treatment areas include nasolabial folds, worry lines, crow's feet, lips/chin/cheek augmentation, marionette lines, smile lines, perioral lines, and wrinkles at the décolletage ... According to information on the company Web site, patients are able to see the lines and wrinkles on their face softening and becoming less noticeable immediately after treatment. Results improve during the first week or so and continue for about 6 to 12 months before additional treatments are needed"
  • Facial Wrinkles Linked to Lower Bone Density - WebMD, 6/7/11 - "Researchers measured the number and depth of facial wrinkles and the skin firmness of 114 women who were within three years of their last menstrual period ... Women who had worse wrinkles also had lesser bone density ... Pal thinks the connection may be a protein called type 1 collagen, a building block of skin and bone tissue, which is lost with age. It is thought that this loss may be accelerated during menopause, when hormone levels drop ... The strongest association of the facial wrinkles with the bone was between the eyebrows ... When we looked at the effects of sun exposure on skin, we did not see that women who had more sun exposure had worse skin wrinkles"
  • Nutrition and aging skin: sugar and glycation - Clin Dermatol. 2010 Jul-Aug;28(4):409-11 - "The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements"
  • Phosphorous in sodas and processed foods accelerates signs of aging, study suggests - Science Daily, 4/26/10 - "high levels of phosphates may add more "pop" to sodas and processed foods than once thought. That's because researchers found that the high levels of phosphates accelerate signs of aging. High phosphate levels may also increase the prevalence and severity of age-related complications, such as chronic kidney disease and cardiovascular calcification, and can also induce severe muscle and skin atrophy"
  • Why Women Wrinkle Around Mouth - WebMD, 12/16/09
  • Zap! Wrinkles And Sun Spots Be Gone - Science Daily, 6/1/09 - “Patients are generally treated in two passes. The first pass acts very deeply on the skin, working on deeper lines, atrophic scars and the like,” Orringer says. “The second, more superficial pass, typically focuses more on blending skin tones and getting rid of sun spots and uneven pigmentation.”
  • Face facts: Too much sugar causes wrinkles - MSNBC, 10/21/07 - "At blame is a natural process that's known as glycation, in which the sugar in your bloodstream attaches to proteins to form harmful new molecules called advanced glycation end products (or, appropriately, AGEs for short). The more sugar you eat, the more AGEs you develop. "As AGEs accumulate, they damage adjacent proteins in a domino-like fashion," ... Supplement your diet with at least 1 mg of vitamins B1 and B6 a day. These vitamins proved to be potent AGE inhibitors in a number of published studies"
  • Smokers' Skin Is More Wrinkled, Even In Areas Shielded From Sunlight - Science Daily, 3/22/07
  • Multiple Low-Energy Plasma Skin Treatments May Help Diminish Facial Wrinkles - Doctor's Guide, 2/20/07 - "Three months after treatment, the participants had 37% fewer wrinkles as judged by the researchers, and the patients reported a 68% improvement in overall facial appearance. Tissue had re-grown over the treated area after four days, while patient-reported redness lasted six days. No scarring or loss of pigment occurred. When examining the biopsied skin tissue under a microscope, the researchers found that a new band of collagen, the primary protein in skin, had formed in the inner layers of the skin"
  • Study: Most Wrinkle Creams Don't Work - WebMD, 12/14/06 - "In their first-ever investigation to compare wrinkle creams, Consumer Reports investigators tested nine products, ranging in price from $38 to $335 ... The investigation found only slight improvements overall in wrinkles for any of the tested products"
  • Women's Skin May Age Faster - WebMD, 10/5/06
  • How Long Do Wrinkle Fillers Last? - WebMD, 2/17/06
  • How to Get Younger Looking Hands - ABC News, 10/18/05
  • Fewer Wrinkles And Firmer Skin Linked To Earlier Use Of Estrogen Therapy - Science Daily, 8/26/05 - “We don’t believe hormone therapy will make wrinkles melt away once they’re already there, but the results of our study shows that hormone therapy can prevent them. Hormone therapy makes wrinkles less severe and keeps skin more elastic”
  • Wiping out wrinkles - MSNBC, 2/25/04 - "And in December, the FDA OK'd Restylane, the first drug in a new class of fillers known as hyaluronic acids. Restylane contains a naturally occurring component of skin that serves as a lubricant and shock absorber in joints. It also doesn't require skin testing and the results can last six to nine months or more, twice as long as collagen"
  • New Treatments to Chase Away Wrinkles, Frowns - HealthDay, 9/19/03
  • Wrinkle erasers fill market - USA Today, 5/18/03
  • New Wrinkle Treatment -- Plexiglas [Artecoll] - CBS News, 4/24/03
  • New Treatments for Facial Wrinkles, Acne Scars - HealthDay, 3/12/03
  • New Product [Artecoll] Erases Wrinkles Permanently - The San Diego Channel, 2/26/03
  • New Skin Cream [Avage] Reverses Sun Damage - WebMD, 11/22/02 - "At the 24-week point, researchers found significantly more patients who used the tazarotene cream experienced a more than 50% overall improvement in skin appearance compared to those who received the placebo. The Avage users also reported less wrinkling, mottled pigmentation, and skin roughness" - See See Tazorac at Drugstore.comicon, prescription required.
  • Botulinum Toxin Can Go Systemic for Facial Lines - Doctor's Guide, 9/24/02
  • Palmitoyl Pentapeptide Improves Photo-aged Skin - Doctor's Guide, 7/2/02
  • Premature Skin Wrinkling And Cigarette Smoking In Young People Connected - Doctor's Guide, 3/26/02
  • Signs Of Premature Aging Significantly Improved With Daily Tazarotene Cream - Doctor's Guide, 2/26/02
  • Retinol and Salicylic Acid Combination Facial Cream Improves Both Acne And Photo Aging - Doctor's Guide, 2/24/02 - "developed and tested the efficacy of a new combination facial cream containing stabilized all-trans-retinol 0.075% (vitamin A), salicylic acid 2%, pro-vitamin B5 and anti-oxidants versus placebo ... By the eighth week of treatment, dermatologists noted significant differences between women who used the test cream and placebo controls in coarse wrinkling, laxity of skin, actinic lentigines and skin texture ... Acne products can dehydrate the skin making wrinkles look worse, while some anti-aging products aggravate acne-prone skin ... women are often forced to choose products to treat their more bothersome condition, often at the detriment of the other"
  • Sun Damage to the Skin Can Be Treated - Medscape, 10/00
  • FDA Approves New Formulation Of Renova (Tretinoin Cream) For Reduction Of Fine Facial Wrinkles - Doctor's Guide, 9/6/00