|
|
|
Home >
Anti-aging Research > Rosemary Extract
Rosemary Extract
Specific Recommendations:
News & Research:
Abstracts:
-
Rosmarinic acid relieves
LPS-induced sickness and depressive-like behaviors in mice by activating the
BDNF/Nrf2 signaling and autophagy pathway - Behav Brain Res 2022 Jul 14 -
"Neuroinflammation is one of the main causes of sickness
and depressive-like behavior. Rosmarinic acid (RA) has been shown to have a
significant anti-neuroinflammatory effect ... Taken together, our research found
that RA could effectively alleviate sickness behaviors and nerve injury caused
by neuroinflammation, and its protective effects were mediated by the Nrf2
signaling pathway, which reduced cellular oxidative stress, inflammation,
mitochondrial respiratory function damage, and autophagy imbalance. Therefore,
RA has the potential to prevent or treat sickness and depressive-like behaviors
under conditions of neuroinflammation" - See
rosemary extract at Amazon.com.
-
Rosmarinic Acid Inhibits
Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth
Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via
Activation of the Keap1-Nrf2-ARE Antioxidant System - J Agric Food Chem 2022
Jun 10 - "The activation of platelets and proliferation
of vascular smooth muscle cells (VSMCs) in the vascular intima play an essential
role in the pathological mechanism of vascular restenosis (RS). Rosmarinic acid
(RA) is a natural phenolic acid compound ... these results indicate that RA
inhibits platelet function and attenuates the proliferation, migration, and
phenotypic transition of VSMCs induced by PDGF-BB in vitro and vascular
remodeling in vivo. Therefore, RA treatment may be a potential therapy for
preventing or treating RS" - See
rosemary extract at Amazon.com.
-
Rosmarinic acid ameliorated
psoriatic skin inflammation in mice through the novel inhibition of the
interleukin-17A/interleukin-17A receptor interaction - Food Funct 2022 Jun 8
- "this is the first study reporting that rosmarinic
acid is an IL-17A-targeting agent that ameliorates psoriatic skin inflammation
in mice via blocking the IL-17A/IL-17RA interaction"
-
Rosmarinic acid protects
mice from Concanavalin A-induced hepatic injury through AMPK signaling -
Biol Pharm Bull 2020 Sep 4 - "Rosmarinic acid (RA) ...
The objective of this study was to investigate the role of AMPK signaling
involving the protective effects of RA on concanavalin A (Con A)-induced(AIH) in
mice ... Compared with the Con A group, serum levels of alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) in RA group (100 and 150 mg/kg/day)
were significantly reduced. RA also reduced hepatocyte swelling, cell death, and
infiltration of leukocytes in the liver of Con A-treated mice. Serum levels of
cytokines, such as interferon-γ(IFN-γ), interleukin-2 (IL-2) and
interferon-1(IL-1β), were reduced by RA pretreatment, while the levels of serum
interferon-10 (IL-10), an anti-inflammatory cytokine, was elevated. These
protective effects were reversed by treatment with CC. RA treatment reduced the
hepatic damage via the activation of AMPK in the mice of Con A-induced. So RA
acts as a potential part in the therapy of autoimmune hepatitis"
-
The Protective Effect of
Rosmarinic Acid Against Unfavorable Influence of Methylparaben and Propylparaben
on Collagen in Human Skin Fibroblasts - Nutrients. 2020 May 1 -
"Parabens, which are widely used in food, medicines and
cosmetics, have a harmful effect on human health. People are most exposed to
parabens transdermally by using cosmetic products containing these
preservatives. The purpose of this study was to estimate the influence of
parabens (methylparaben-MP and propylparaben-PP) on the metabolism of collagen
in the human skin fibroblasts and above all, to assess whether rosmarinic acid
(RA-50, 100, or 150 M) can protect these cells from the adverse effects of
parabens (0.001% MP and 0.0003% PP, 0.003% MP and 0.001% PP, and 0.01% MP and
0.003% PP). The possible mechanisms of RA action were estimated as well.
Parabens decreased the expression of collagen type I and III at mRNA and protein
levels, while RA (depending on the concentration) provided partial or total
protection against these changes. The effective protection against the adverse
effects of parabens on cell viability and proliferation was also provided by RA.
The beneficial impact of RA on collagen and the fibroblasts resulted from an
independent action of this compound and its interaction with parabens. This
study allows us to conclude that this polyphenolic compound may protect from
unfavorable health outcomes caused by lifetime human exposure to parabens
contained in cosmetic products"
-
Skin photoprotective and
antiageing effects of a combination of rosemary (Rosmarinus officinalis) and
grapefruit (Citrus paradisi) polyphenols - Food Nutr Res. 2016 Jul
1;60:31871 - "We investigated the efficacy of a
combination of rosemary (R. officinalis) and grapefruit (C. paradisi) in
decreasing the individual susceptibility to UVR exposure (redness and
lipoperoxides) and in improving skin wrinkledness and elasticity ... Treated
subjects showed a decrease of the UVB- and UVA-induced skin alterations
(decreased skin redness and lipoperoxides) and an improvement of skin
wrinkledness and elasticity. No differences were found between the 100 and 250
mg extracts doses, indicating a plateau effect starting from 100 mg extracts
dose. Some of the positive effects were noted as short as 2 weeks of product
consumption ... The long-term oral intake of Nutroxsun™ can be considered to be
a complementary nutrition strategy to avoid the negative effects of sun
exposure" - [Nutra
USA] - See Nutroxsun™ at Amazon.com.
-
Rosmarinic acid protects
against chronic ethanol-induced learning and memory deficits in rats - Nutr
Neurosci. 2016 Jul 1:1-8 - "Ethanol consumption induces
neurological disorders including cognitive dysfunction. Oxidative damage is
considered a likely cause of cognitive deficits ... Memory impairment was
induced by 15% w/v ethanol (2 g/kg, i.g.) administration for 30 days. RA (8, 16,
and 32 mg/kg, i.g.) or donepezil (2 mg/kg, i.g.) was administered 30 minutes
before ethanol ... RA 32 mg/kg had comparable effects with donepezil in
prevention of acquisition and retention memory impairment. The higher doses of
RA not only prevented increased lipid peroxidation and nitrite content but also
decreased SOD, CAT, GSH, and FRAP levels in alcoholic groups and exerted
antioxidant effects in non-alcoholic rats ... RA represents a potential
therapeutic option against chronic ethanol-induced amnesia which deserves
consideration and further examination" - See
rosmarinic acid at Amazon.com. Note
that it shows rosemary extract but if you look at the label they're standardized
to a percentage of rosmarinic acid.
-
Carnosic
acid as a major bioactive component in rosemary extract ameliorates high-fat
diet-induced obesity and metabolic syndrome in mice - J Agric Food Chem.
2015 Apr 30 - "The mice were given a low-fat diet, a high-fat diet or a high-fat
diet supplemented with either 0.14% or 0.28% (w/w) CA-enriched RE (containing
80% CA, RE#1L and RE#1H), or 0.5% (w/w) RE (containing 45% CA, RE#2), for a
period of 16 weeks ... The dietary RE supplementation significantly reduced body
weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver
weight, liver triglyceride and free fatty acid levels compared with the mice fed
with HF diet without RE treatment. RE administration also decreased the levels
of plasma and liver malondialdehyde, advanced glycation end products (AGEs) and
the liver expression of receptor for AGE (RAGE) compared with mice of HF group"
- See rosemary extract at Amazon.com
 .
|
|
