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Home > Health Conditions > Mental Health

Mental Health

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  • Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk - Nutrients 2023 Apr 4 - "Several studies have reported that vitamin D deficiency may be a relevant risk factor for depression, and vitamin D supplementation has shown promising effects in the adjunctive treatment of this mood disorder. Among the beneficial mechanisms of vitamin D, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide" - See vitamin D at Amazon.com.
  • Glutathione a Potential Biomarker for Postpartum Suicide - Medscpe, 4/7/23 - "reduced serum GSH levels were significantly lower for those with moderate to high suicide risk than for those without suicide risk. Their findings suggest that GSH may be a potential biomarker or etiologic factor among women at risk for suicide, with therapeutic implications" - Note: The best way in increase glutathione is to take NAC. See n-acetyl cysteine at Amazon.com.
  • Vitamin D Linked to Lower Risk of Suicide Attempts, Self-Harm - WebMD, 2/1/23 - "About 490,885 veterans who received vitamin D3 and 169,241 veterans who received vitamin D2 were compared to veterans of similar demographics and medical histories who didn’t receive supplements ... Overall, vitamin D3 use was linked to a 45% lower risk of suicide attempts and self-harm, and vitamin D2 was linked to a 48% lower risk" - See vitamin D at Amazon.com.
  • The role of metformin as a treatment for neuropsychiatric illness - Eur Neuropsychopharmacol 2022 Sep 29 - "Metformin is a widely used hypoglycaemic agent that is now being studied for use beyond diabetes management. Evidence is emerging that metformin has multiple effects on diverse neurobiological pathways and consequently may be repurposed for treating mental illness. Metformin may have beneficial neuroimmunological, neuroplastic, neuro-oxidative and neuro-nitrosative effects across a range of psychiatric and neurodegenerative illnesses. Mechanisms include glucose lowering effects and effects on AMP-activated protein kinase (AMPK) signalling, however the best evidence for clinical benefit is through the glucose lowering effects, with other mechanisms less supported by the current evidence base" - See metformin at ReliableRX.
  • Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial -Nutrients 2022 Jun 6 - "The importance of maintaining good mental health with overall well-being has recently drawn attention from various spheres of academics and the working population. Amino acid intake has been reported to reduce depression symptoms and other mental health problems. However, the effectiveness of amino acid intake (i.e., single or combined) remains unknown. In this study, we assessed a combination of five amino acids (serine, alanine, glutamate, aspartate, and tyrosine; SAGAT) reported to regulate mental health ... The current findings suggest that SAGAT contributes to maintaining proper motivation and cognitive function" - See serine at Amazon.com, beta-alanine at Amazon.com, glutamate supplements at Amazon.com, aspartate supplements at Amazon.com, and n-acetyl tyrosine at Amazon.com.
  • Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders - Nutr Neurosci 2022 Mar 21 - "Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in various plant foods and Chinese herbal medicines. Accumulating evidence indicates that OA and UA exhibit neuroprotective effects on multiple brain disorders" - See ursolic acid at Amazon.com.
  • Effect of Vitamin D Supplementation in Early Psychosis - Medscape, 12/29/21 - "While we did not demonstrate a benefit of supplementation over 6 months, these very high rates of vitamin deficiency and insufficiency may have longer-term negative health impacts which we have not measured, so raising awareness of the need to optimize vitamin D in people with psychosis is important" - See vitamin D at Amazon.com.
  • Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial - Nutr J 2021 Nov 13 - "We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured ... After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score" - See curcumin at Amazon.com.
  • Gut Health 'Vitally Important' for Mental Health - Medscape, 9/21/21 - "A meta-analysis of 59 studies, encompassing roughly 2600 patients with psychiatric conditions, showed a decrease in microbial richness in patients with psychiatric conditions vs controls." - See probiotic supplements at Amazon.com and iHerb.
  • Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial - Nutrients 2021, 13(8) - "The human gut microbiome is closely linked to mental health and sleep. We aimed to verify the efficacy and safety of probiotic NVP-1704, a mixture of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98, in improving stress, depression, anxiety, and sleep disturbances, along with the measurement of some blood biomarkers. A total of 156 healthy adults with subclinical symptoms of depression, anxiety, and insomnia were retrospectively registered and randomly assigned to receive either NVP-1704 (n = 78) or a placebo (n = 78) for eight week ... After intervention, gut microbiota composition was quantified by pyrosequencing the bacterial 16S rRNA gene. The NVP-1704 group had a more significant reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks compared to the placebo group. Those receiving NVP-1704 also experienced an improvement in sleep quality. NVP-1704 treatment led to a decrease in serum interleukin-6 levels. Furthermore, NVP-1704 increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition. Our findings suggest that probiotic NVP-1704 could be beneficial for mental health and sleep" - [Nutra USA] - See probiotic supplements at Amazon.com and iHerb.
  • Three pillars of mental health: Good sleep, exercise, raw fruits and veggies - Science Daily, 12/16/20 - "Along with quality sleep, exercising, and eating more raw fruits and vegetables -- in that order -- were three modifiable behaviours which correlated with better mental health and well-being in young adults"
  • High Rates of B Vitamin Deficiency in Teens With Mental Illness - Medscape, 4/10/19 - "Levels of vitamin B9 and B12 deficiency are high in children and particularly adolescents with psychiatric disorders ... Deficiencies in these two vitamins lead to hyperhomocysteinemia, which has been linked to neurovascular and neurodegenerative disorders and psychiatric disorders, including schizophrenia and affective disorders, as well as cognitive impairment ... To determine levels of deficiency of vitamin B9 and B12, the investigators retrospectively examined the records of all child and adolescent psychiatric inpatients between 2015 and 2017 at their center ... Vitamin B9 deficiency was detected in 42.4% of the patients, and 19.2% were deficient in vitamin B12; 11.0% were deficient in both vitamins" - See B complex supplements at Amazon.com.
  • Adjunctive nutrients in first-episode psychosis: A systematic review of efficacy, tolerability and neurobiological mechanisms - Early Interv Psychiatry. 2018 Mar 21 - ""first-episode psychosis" (FEP) ... Eleven studies with a total of 451 patients with FEP (from 8 independent randomized controlled trials) were eligible for inclusion. Six studies examined omega-3 fatty acids, with inconsistent effects on psychiatric symptoms. However, mechanistic studies found significant improvements in hippocampal neuronal health and brain glutathione. Antioxidants "n-acetyl cysteine" (n = 1) and vitamin C (n = 2) also improved oxidative status in FEP, which was associated with reduced psychiatric symptoms. No benefits were found for vitamin E (n = 1). Finally, one study trialling the amino acid taurine, showed significant improvements in positive symptoms and psychosocial functioning" - [Nutra USA] - See n-acetyl cysteine, vitamin C and taurine at Amazon.com.
  • Antioxidants and amino acids could play role in the treatment of psychosis - Science Daily, 3/22/18 - "certain nutrient supplements, used alongside standard treatment, may improve mental health in young people with psychosis more than standard treatment alone ... 4 grams of Taurine per day reduced psychotic symptoms within just 12 weeks ... Certain antioxidant supplements, such as n-acetyl cysteine and vitamin C, may also be effective -- particularly for patients with high levels of 'oxidative stress' ... Studies on omega-3 supplements showed that although these appear to improve brain health in young people with psychosis, the evidence for actually reducing psychotic symptoms is conflicting" - See taurine at Amazon.com.
  • Low Folate, Vitamin D Implicated in First-Episode Psychosis - Medscape, 12/22/17 - "levels of vitamin C, D, and folate "should be assessed in young people being treated for psychosis, and if deficient, clinicians should recommend dietary improvement or perhaps even supplementation if diet alone cannot resolve the deficits."
  • Probiotics and Subclinical Psychological Symptoms in Healthy Participants: A Systematic Review and Meta-Analysis - J Altern Complement Med. 2016 Nov 14 - "These results show that probiotic consumption may have a positive effect on psychological symptoms of depression, anxiety, and perceived stress in healthy human volunteers" - See probiotic products at Amazon.com.
  • The impact of gut microbiota on brain and behaviour: implications for psychiatry - Curr Opin Clin Nutr Metab Care. 2015 Sep 12 - "Recently, the gut microbiota has been profiled in a variety of conditions including autism, major depression and Parkinson's disease ... The current narrative suggests that certain neuropsychiatric disorders might be treated by targeting the microbiota either by microbiota transplantation, antibiotics or psychobiotics" - See probiotic products at Amazon.com.
  • Green spaces deliver lasting mental health benefits - Science Daily, 1/7/14 - "used data from the British Household Panel Survey, a repository of information gathered from questionnaires filled in by households across Great Britain ... They found that, on average, movers to greener areas experienced an immediate improvement in mental health that was sustained for at least 3 years after they moved"
  • Probiotics a Potential Treatment for Mental Illness - Medscape, 11/19/13 - "although human studies are still largely lacking, they did find some with promising results on behavior, including 1 showing that healthy volunteers who received Lactobacillus helveticus R0052 plus B longum for 30 days reported significantly lower stress levels than those who received placebo, as well as significantly reduced urinary free cortisol levels ... Another study of 124 volunteers (mean age, 61.8 years) showed that those who consumed probiotic-containing yogurt for 3 weeks had significantly improved mood compared with those who received placebo ... the term "psychobiotic" was created as recent studies have begun to explore a possible link between probiotics and behavior ... As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid [GABA] and serotonin, which act on the brain-gut axis ... a study of human patients with chronic fatigue syndrome showed that those who consumed an active strain of L casei 3 times a day had significantly higher improvement scores on anxiety measures than did those who received matching placebo" - See probiotic products at Amazon.com.
  • Amino acid offers potential therapeutic alternative in psychiatric disorders - Science Daily, 10/8/13 - "drug discovery is at a near standstill for treating psychiatric disorders such as schizophrenia, bipolar disorder, depression and common forms of autism ... According to Professor Berk, there is now an incontrovertible evidence base that these disorders share inflammation and oxidative stress as part of their disease physiology ... The amino acid, NAC, seems to have multiple effects on all these pathways: it boosts glutathione, which is the body’s major antioxidant defence; has anti-inflammatory properties; enhances levels of nerve cell growth proteins and the growth of new neurons; and reduces cell death pathways. It also appears to reduce dysfunction of mitochondria ... NAC reduces the core symptoms of schizophrenia including negative symptoms such as improved apathy, social interaction and motivation. It also appears to reduce depression in people with bipolar disorder and at this meeting ... there is intriguing evidence that it reduces cravings in a number of addictions including cocaine, cannabis and cigarette smoking" - See n-acetyl cysteine at Amazon.com.
  • Vitamin D Insufficiency Prevalent in Psychiatric Patients - Medscape, 7/22/13 - "Among the patients, 75% had vitamin D levels lower than 30 ng/mL, generally considered by groups, including the American College of Physicians, to represent insufficiency ... Vitamin D insufficiency may be a causative factor in the pathogenesis of mental illness through interactions that affect cellular mechanisms, which eventually diverge into different clinically observed phenotypes ... as many as 63% of patients with insufficient vitamin D levels were not treated with supplementation ... Physicians who work in those units should make sure vitamin D screening and evaluation is part of routine evaluation of patients, not necessarily because it may be causative of psychiatric symptoms but because there are a lot of conditions that are associated with vitamin D deficiency — osteoporosis, diabetes, and some other medical problems that are also relatively common in patients with psychiatric illnesses" - See vitamin D at Amazon.com.
  • Iron Deficiency Linked to Psychiatric Disorders in Kids - Medscape, 6/24/13 - "Children and adolescents with iron deficiency anemia (IDA) are at increased risk for psychiatric disorders, including depressive disorder, bipolar disorder, anxiety disorder, and autism ... should check the iron level in those children and adolescents with psychiatric disorders ... Iron plays a key role in brain development, including myelination of white matter and the development and functioning of the different neurotransmitter systems, including the dopamine, norepinephrine, and serotonin systems ... There is well-documented evidence in the literature that IDA has a significant influence on cognitive development, intelligence, and developmental delay ... Odds Ratio ... Bipolar disorder ... 5.80"
  • Many apples a day keep the blues at bay - Science Daily, 1/23/13 - "On days when people ate more fruits and vegetables, they reported feeling calmer, happier and more energetic than they normally did ... After further analysis we demonstrated that young people would need to consume approximately seven to eight total servings of fruits and vegetables per day to notice a meaningful positive change. One serving of fruit or vegetables is approximately the size that could fit in your palm, or half a cup"
  • Finger Length a Marker of Verbal Aggression? - Medscape, 11/30/12 - "Those who had smaller 2D:4D ratios, which correlates with prenatal exposure to testosterone, reported more verbal aggression behaviors than did the participants with higher ratios ... prenatal androgen exposure (PNAE) ... Most importantly, data indicate that 2D:4D is a proxy for sex hormones levels at the time of brain organization ... The ratio did not correlate with either argumentativeness or openness to other experiences"
  • Study to determine whether fish oil can help prevent psychiatric disorders - Science Daily, 2/8/12 - "Researchers at Zucker Hillside Hospital's Recognition and Prevention (RAP) Program who have worked with teenagers at risk for serious mental illness for the past decade are now studying the effectiveness of Omega 3 fatty acids (fish oil) for treating psychiatric symptoms ... Of the 300 adolescents who have participated in the RAP Program, most have shown substantial improvement" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • US military: Low omega-3 levels may boost suicide risk - Nutra USA, 8/25/11 - "Low DHA status can be readily reversed using low-cost dietary interventions that are likely to have multiple beneficial health effects ... We were surprised to find just how low the levels of omega-3 fatty acids were in the entire sample ... for every incremental decrease in DHA levels, the risk of suicide death increased by 14% .. the risk was significant amongst men, with the lowest DHA levels associated with a 62% increase in suicide risk ... suicide is linked to a combination of factors, included social, psychological, and environmental factors. Indeed, the risk of suicide was 52% higher in service personnel who reported having seen wounded, dead, or killed coalition personnel ... a previous placebo-controlled trial demonstrated that 2 grams of omega-3 fatty acids per day reduced suicidal thinking by 45 percent, along with depression and anxiety scores among individuals with recurrent self-harm" - See Jarrow Max DHA at Amazon.com. - Related articles:
  • Low Vitamin D: A Contributor to Mental Disorders in Children? - Medscape, 6/2/11 - "Children with severe mental health disorders, including psychosis, have twice the rate of vitamin D insufficiency as mentally healthy children ... 21% of children with severe psychiatric symptoms requiring residential care had serum 25-hydroxyvitamin D (25[OH]D) levels lower than 20 ng/mL (the American Academy of Pediatrics [AAP] minimum recommended level) compared with 14% of children who were participants in the National Health and Nutrition Examination Survey III (NHANES III), a population-based study designed to assess the health and nutritional status of children and adults in the United States" - See vitamin D at Amazon.com.
  • 'Knowing it in your gut' is real - Science Daily, 3/23/11 - "the "cross-talk" between bacteria in our gut and our brain plays an important role in the development of psychiatric illness, intestinal diseases and probably other health problems as well including obesity ... Using germ-free mice, Foster's research shows gut bacteria influences how the brain is wired for learning and memory ... genes linked to learning and memory are altered in germ-free mice and, in particular, they are altered in one of the key brain regions for learning and memory -- the hippocampus ... The take-home message is that gut bacteria influences anxiety-like behavior through alterations in the way the brain is wired" - See probiotics at Amazon.com.
  • Fish oil may reduce the risk of psychotic disorders in high-risk individuals - Science Daily, 2/1/10 - "For 12 weeks, 41 individuals were assigned to take daily fish oil capsules containing 1.2 grams of omega-three polyunsaturated fatty acids and 40 were assigned to take placebo; a total of 76 (93.8 percent) completed the intervention. By the end of the study, two (4.9 percent) in the omega-3 group and 11 (27.5 percent) in the placebo group had transitioned to psychotic disorder. The difference between progression to psychosis was 22.6 percent ... Polyunsaturated fatty acids also significantly reduced symptoms and improved functioning compared with placebo" - [WebMD] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Long-Chain {omega}-3 Fatty Acids for Indicated Prevention of Psychotic Disorders: A Randomized, Placebo-Controlled Trial - Arch Gen Psychiatry. 2010 Feb;67(2):146-54 - "The difference between the groups in the cumulative risk of progression to full-threshold psychosis was 22.6% ... Long-chain omega-3 PUFAs reduce the risk of progression to psychotic disorder and may offer a safe and efficacious strategy for indicated prevention in young people with subthreshold psychotic states" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at iHerb.
  • Effect of zinc supplementation on mood states in young women: a pilot study - Eur J Clin Nutr. 2010 Jan 20 - "multivitamins (MVs) ... who took MV and Zn showed a significant reduction in anger-hostility score (P=0.009) and depression-dejection score (P=0.011) in the Profile of Moods State (POMS) and a significant increase in serum Zn concentration (P=0.008), whereas women who took only MV did not"
  • Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial - Am J Clin Nutr. 2008 Dec 30 - "Psychological distress (PD) ... To our knowledge, this is the first trial of n-3 supplementation in the treatment of PD and depressive symptoms in middle-aged women. In women with PD without MDE at baseline, the 8-wk changes in PD and depressive scales improved significantly more with E-EPA than with placebo" - See Mega Twin EPA at Amazon.com.
  • Essential Fatty Acid Accelerates Treatment Response in Early Psychosis - Medscape, 1/22/08 - "For the primary and secondary prevention of emerging psychotic disorders, physicians should "keep an open mind towards neuroprotective substances, such as omega-3 fatty acids or other experimental neuroprotective substances,"" - See Mega Twin EPA at iHerb.
  • Iron Deficiency Alters Brain Development and Functioning - J. Nutr. 133:1468S-1472S, May 2003 - "Iron deficiency anemia in early life is related to altered behavioral and neural development. Studies in human infants suggest that this is an irreversible effect that may be related to changes in chemistry of neurotransmitters, organization and morphology of neuronal networks, and neurobiology of myelination"
  • Polyunsaturated Fats and Neurological Disorders - Nutrition Science News, 9/00
  • DHEA: A Mental & Physical Boost - Life Extension Magazine, 12/99
  • Fat in the diet may affect mental ability - CNN, 9/4/98
  • The Marriage of DHEA and 5-HTP for New and Better Mood Function - Life Enhancement Magazine, 7/99

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