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Home > Health Conditions > Anemia


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  • Real-World data on efficacy of L-glutamine in preventing sickle cell disease-related complications in pediatric and adult patients - Front Med (Lausanne) 2022 Aug 1 - "L-glutamine has been shown to play an important role in the regulation of oxidative stress which is one of the key contributors to the pathophysiology of sickle cell disease (SCD). In a Phase 3 clinical trial, L-glutamine demonstrated a significant reduction in SCD-related complications including vaso-occlusive crises (VOCs), hospitalizations, and acute chest syndrome (ACS) compared to placebo in patients with SCD ... Compared to baseline, patients had significantly fewer pain crises (median change from 3.0 to 0.0; P < 0.00001), hospitalizations (median change from 3.0 to 0.0; P < 0.00001), days of hospitalization (median change from 15.0 to 0.0; P < 0.00001), and blood transfusions (median change from 3.0 to 0.0; P < 0.00001) at 24, 48, and 72 weeks following L-glutamine therapy. Moreover, there was a drastic decrease in the number of ACS events during this time. A significant increase was observed in mean hemoglobin levels and hematocrit proportions from baseline to 72 weeks (P < 0.001). Conversely, compared to baseline, mean reticulocyte counts and lactate dehydrogenase (LDH) levels were considerably lower at follow-up time points (P = 0.003 and P < 0.001, respectively). No patient reported treatment-related adverse events" - See L-glutamine at Amazon.com.
  • ossible Mechanism of Hematocrit Elevation by Sodium Glucose Cotransporter 2 Inhibitors and Associated Beneficial Renal and Cardiovascular Effects - Circulation 2019 Apr 23 - "SGLT2 inhibitor therapy is associated with a modest increase in hematocrit (2%–4%) relative to placebo, and this effect is consistent for all 4 SGLT2 inhibitors (empagliflozin, canagliflozin, dapagliflozin, and ertugliflozin)" - See empagliflozin inhousepharmacy.vu.
  • Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Hemoglobin Levels: A Meta-analysis of Randomized Controlled Trials - Front Pharmacol 2021 - "Compared to control patients, SGLT2 inhibitors were shown to increase hemoglobin levels in patients with T2DM and chronic kidney disease (standard mean difference = 0.70" - See empagliflozin inhousepharmacy.vu.
  • Positive Association of Vitamin E Supplementation with Hemoglobin Levels in Mildly Anemic Healthy Pakistani Adults - Int J Vitam Nutr Res. 2015;85(1-2):39-49 - "The study showed a positive association between vitamin E supplementation and enhanced hemoglobin levels in mildly anemic adults" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls: a randomised clinical trial - Eur J Clin Nutr. 2015 Dec 23 - "iron folic acid (IFA) ... IFA supplementation with or without vitamin B12 is an effective measure to cure anaemia. Although addition of vitamin B12 had similar impact on improving haemoglobin status as IFA alone, it resulted in better ferritin status. Hence, more multi-centre studies with a longer duration of supplementation or higher dose of vitamin B12 may be undertaken to assess the possible impact of vitamin B12 on improving haemoglobin levels in the population"
  • Iron supplements improve anemia, quality of life for women with heavy periods - Science Daily, 6/9/14 - "One year after treatment women in the anemic group had a significant increase in energy, along with physical and social function, and a decrease in anxiety and depression compared to the non-anemic group. It took five years for the iron stores to reach normal levels" - See iron supplements at Amazon.com.
  • Low vitamin D levels raise anemia risk in children - Science Daily, 10/21/13 - "their results are not proof of cause and effect, but rather evidence of a complex interplay between low vitamin D levels and hemoglobin, the oxygen-binding protein in red blood cells. The investigators say several mechanisms could account for the link between vitamin D and anemia, including vitamin D's effects on red blood cell production in the bone marrow, as well as its ability to regulate immune inflammation, a known catalyst of anemia ... researchers studied blood samples from more than 10,400 children, tracking levels of vitamin D and hemoglobin. Vitamin D levels were consistently lower in children with low hemoglobin levels compared with their non-anemic counterparts, the researchers found" - See vitamin D at Amazon.com.
  • One Iron Pill a Day Keeps Fatigue Away? - Medscape, 8/20/13 - "evidence is growing that fatigue in non-anaemic, menstruating women with low ferritin can be influenced positively by iron supplementation ... the authors randomised 198 menstruating women with considerable fatigue (>6 on a 1–10 Likert scale), ferritin levels less than 50 μg/l and haemoglobin ≥12 g/dl to have 80 mg oral ferrous sulphate or placebo for 12 weeks ...A total of 47.7% of the patients in the iron group compared with 28.8% in the placebo group reported decreased fatigue. Quality of life, depression and anxiety were not affected ... As in all oral iron trials, darkening of stool leads to possible differentiation of verum from placebo, therefore, blinding was not totally assured; a substantial limitation considering the huge placebo effect on fatigue reported in studies using parenteral iron"
  • Iron Deficiency Linked to Psychiatric Disorders in Kids - Medscape, 6/24/13 - "Children and adolescents with iron deficiency anemia (IDA) are at increased risk for psychiatric disorders, including depressive disorder, bipolar disorder, anxiety disorder, and autism ... should check the iron level in those children and adolescents with psychiatric disorders ... Iron plays a key role in brain development, including myelination of white matter and the development and functioning of the different neurotransmitter systems, including the dopamine, norepinephrine, and serotonin systems ... There is well-documented evidence in the literature that IDA has a significant influence on cognitive development, intelligence, and developmental delay ... Odds Ratio ... Bipolar disorder ... 5.80"
  • Low vitamin D in kids may play a role in anemia - Science Daily, 5/1/11 - "vitamin D deficiency may play an important role in anemia ... looked at data from the blood samples of more than 9,400 children, 2 to 18 years of age. The lower the vitamin D levels, the lower the hemoglobin and the higher the risk for anemia, the researchers found. Children with levels below 20 nanograms per milliliter (ng/ml) of blood had a 50 percent higher risk for anemia than children with levels 20 ng/ml and above. For each 1 ng/ml increase in vitamin D, anemia risk dropped by 3 percent" - See vitamin D at Amazon.com.
  • Spirulina shows immune boosting power for seniors - Nutra USA, 2/17/11 - "Twelve weeks of spirulina supplementation were associated with increased counts of white blood cells, foot soldiers of the immune system ... Immune function was measured using complete blood cell (CBC) counts and indoleamine 2,3-dioxygenase (IDO) enzyme activity, and results showed that over half of all participants receiving spirulina had higher IDO activity after 6 and 12 weeks, while this proportion was “striking in men with over 75 percent of subjects manifesting such phenomenon” ... In terms of cell counts, spirulina was associated with a steady increase in corpuscular hemoglobin, thereby ameliorating anemia" - [Abstract] - See spirulina at Amazon.com.
  • The effects of Spirulina on anemia and immune function in senior citizens - Cell Mol Immunol. 2011 Jan 31 - "Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study. Complete cell count (CCC) and indoleamine 2,3-dioxygenase (IDO) enzyme activity, as a sign of immune function, were determined at baseline and weeks 6 and 12 of supplementation. Thirty study participants completed the entire study and the data obtained were analyzed. Over the 12-week study period, there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes. In addition, mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants. Older women appeared to benefit more rapidly from Spirulina supplements. Similarly, the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation. Spirulina may ameliorate anemia and immunosenescence in older subjects" - See spirulina products at iHerb.
  • Not Enough B12? - Dr. Weil, 1/20/04
  • Iron Supplements May Help Fatigued Women - Doctor's Guide, 5/22/03 - "Women who experience unexplained fatigue, but who are not anaemic may benefit from iron supplementation ...The level of fatigue after one month decreased by - 1.82/6.37 points (29%) in the iron group, compared with - 0.85/6.46 points (13%) in the placebo group ... the lower limit for serum ferritin concentration is controversial: iron stores in the bone marrow may serve as a better indicator of iron deficiency, they add. The lower reference limits for serum ferritin and haemoglobin concentrations have been considered too low for women and it has been suggested should be the same as for men" - [Abstract]
  • Taurine Helps Correct Iron-Deficiency Anemia - New Hope Natural Media, 12/19/02 - "Half of the women were also given taurine (1,000 mg per day), while the others received a placebo ... the group receiving taurine had a significantly greater increase in blood count than did the placebo group. The advantage of taurine over placebo was equivalent to the production of more than three-quarters of a pint of additional blood" - See iHerb taurine products.
  • Fighting Fatigue: Iron Overload vs. Anaemia - Functional Foods & Nutraceuticals, 2/02 - "Menstruating women are more likely to feel tired because of an iron deficiency, whereas men 40 years and older are more likely to tire from iron overload ... the anaemia rate of adults older than 85 may be similarly high—ranging from 17 to 28 per cent ... In a state of iron overload, fatigue is often accompanied by arthritis, diabetes, infertility, male impotence, skin pigmentation, and liver or heart disease ... unexplained fatigue may be a physical symptom of masked depression"
  • Dying From Neglect - Life Extension Magazine, 3/02

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