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Anti-aging Research > Ursolic Acid
Ursolic Acid
Specific Recommendations:
News & Research:
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Apple peel compound boosts brown fat, reduces obesity in mice - Science
Daily, 6/20/12 - "The findings suggest that the
substance known as ursolic acid reduces obesity and its associated health
problems by increasing the amount of muscle and brown fat, two tissues
recognized for their calorie-burning properties ... In this study, we tested
ursolic acid in mice on a high-fat diet -- a mouse model of obesity and
metabolic syndrome. Once again, ursolic acid increased skeletal muscle.
Interestingly, it also reduced obesity, pre-diabetes and fatty liver disease
... Since muscle is very good at burning calories, the increased muscle in
ursolic acid-treated mice may be sufficient to explain how ursolic acid
reduces obesity. However, we were surprised to find that ursolic acid also
increased brown fat, a fantastic calorie burner. This increase in brown fat
may also help protect against obesity" - See
ursolic acid products at iHerb.
Abstracts:
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Inhibitory Effect and
Mechanism of Ursolic Acid on Cisplatin-Induced Resistance and Stemness in Human
Lung Cancer A549 Cells - Evid Based Complement Alternat Med 2023 Apr 14; - "The
survival rate of lung cancer patients remains low largely due to chemotherapy
resistance during treatment, and cancer stem cells (CSCs) may hold the key to
targeting this resistance. Cisplatin is a chemotherapy drug commonly used in
cancer treatment, yet the mechanisms of intrinsic cisplatin resistance have not
yet been determined because lung CSCs are hard to identify ... When UA was
applied to the cisplatin-resistant cells, levels of the pluripotent stem cell
transcription factors were restrained by the inhibition of the Jak2/Stat3
signaling pathway, which reduced the enrichment of tumor stem cells, and in
turn, reversed cisplatin resistance in lung cancer cells. Hence, as a potential
antitumor drug, UA may be able to inhibit the enrichment of the lung CSC
population by inhibiting the activation of the Jak2-Stat3 pathway and preventing
the resistance of lung cancer cells to cisplatin" - See
ursolic acid at Amazon.com.
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Ursolic Acid Suppresses
Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity
- J Agric Food Chem 2023 Feb 24 - "Overwhelming evidence
points to an abnormally active Wnt/β-catenin signaling as a key player in
colorectal cancer (CRC) pathogenesis. Ursolic acid (UA) is a pentacyclic
triterpenoid that has been found in a broad variety of fruits, spices, and
medicinal plants. UA has been shown to have potent bioactivity against a variety
of cancers, including CRC, with the action mechanism obscure. ... UA drastically
suppressed proliferation, migration, and clonality; induced apoptosis; and
arrested the cell cycle at the G0/G1 phase of SW620 cells, without the influence
on NCM460 cells, accompanied by weakened activity of the Wnt/β-catenin signaling
pathway. Besides, UA markedly deterred the growth of the xenograft tumor,
ameliorated pathological features, triggered apoptosis, and arrested the cell
cycle in xenograft CRC tissue, by lessening the Wnt/β-catenin signaling cascade.
Overall, UA may inhibit the malignant phenotype, induce apoptosis, and arrest
the cell cycle of CRC, potentially by attenuating the Wnt/β-catenin signaling
axis, providing insights into the mechanism for the potency of UA on CRC"
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Ursolic acid inhibits the
activation of smoothened-independent non-canonical hedgehog pathway in
colorectal cancer by suppressing AKT signaling cascade - Phytother Res 2022
Jun 16 - "Ursolic acid (UA), a pentacyclic triterpenoid
present in many medicinal herbs, manifests potent effectiveness against multiple
malignancies including colorectal cancer (CRC) ... Taken together, UA may
alleviate CRC by suppressing AKT signaling-dependent activation of
SMO-independent non-canonical Hedgehog pathway"
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Oleanolic acid and ursolic
acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric
diseases and other brain disorders - Nutr Neurosci 2022 Mar 21 -
"Brain disorders such as neurodegenerative diseases and
neuropsychiatric diseases have become serious threatens to human health and
quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic
triterpenoid isomers widely distributed in various plant foods and Chinese
herbal medicines. Accumulating evidence indicates that OA and UA exhibit
neuroprotective effects on multiple brain disorders"
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Effect of
Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by
12-O-tetradecanoylphorbol-13-acetate - Cancer Prev Res (Phila).
2015 Jun 22 - "Treatment with UA + Res during skin tumor promotion with TPA
produced greater inhibition of tumor multiplicity and tumor size than with
either agent alone. Collectively, the greater ability of the combination of UA +
Res to inhibit skin tumor promotion was due to the greater inhibitory effects on
growth factor and inflammatory signaling, skin inflammation and epidermal hyperproliferation induced by TPA treatment" -
See
ursolic acid at Amazon.com
and
ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count
at Amazon.com .
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Ursolic acid
increases energy expenditure through enhancing free fatty acid uptake and
β-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle - Mol Nutr
Food Res. 2015 May 5 - "In diet-induced obese rats, 0.5% UA supplementation for
6 weeks markedly reduced body weight, increased energy expenditure, decreased
FFA level in serum and skeletal muscle and triglyceride content in skeletal
muscle ... UA increases FFA burning through enhancing skeletal muscle FFA uptake
and β-oxidation via an UCP3/AMPK-dependent pathway, which provides a novel
perspective on the biological function of UA against obesity and IR"
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