To address the growing use of ad blockers we now use affiliate links to sites like Amazon.com, streaming services, and others. Affiliate links help sites like QualityCounts.com stay open. Affiliate links cost you nothing but help me support my family. We do not allow paid reviews on this site. As an Amazon Associate I earn from qualifying purchases.  Also, you can donate  to ben@qualitycounts.com via Zelle or PayPal.  Click here for the PayPal QR.  Click here for Bitcoin QR code or Bitcoin address: 39muDw6WpQV8j6EdA8eUBvT5iFDiVpVpiE
Home ReliableRXPharmacy Past Newsletters Amazon.com Contact
 Sign-up for newsletter 
 Newsletter Archive
 Newsletter via RSS Feed
 Research on Supplements
 Health Conditions
 Anti-aging Recommendations
 Insulin and Aging
 QualityCounts.com in Time
 Longevity Affiliates:

Home > Health Conditions > Baldness.

Hair Loss

Related Products:

Alternative News:

  • An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study - Health Sci Rep. 2023 Jan - "Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment" - See Pycnogenol at Amazon.com.
  • Review Gives Weight to Supplements for Hair Loss - Medscape, 12/1/22 - "The review begins with a look at studies of saw palmetto (Serenoa repens), a botanical compound thought to inhibit the enzyme 5-alpha reductase (5AR), which converts testosterone to dihydroxytestosterone (DHT). DHT is a mediator of androgenic alopecia (AGA). The studies suggest that the compound might stabilize hair loss, "although its effect is likely less than that of finasteride," write the authors. They also note that side effects associated with finasteride, such as sexual dysfunction, were also observed with saw palmetto "but to a lesser extent" ... For AGA, pumpkin seed oil may also be effective and a "potential alternative" to finasteride for AGA, and Forti5, a nutritional supplement that includes botanical 5AR inhibitors and other ingredients, had favorable effects in one study, the authors write. But neither has been compared to finasteride, and the Forti5 study lacked a control group ... The review also examines the micronutrients vitamin D, zinc, B vitamins, and antioxidants. Low levels of vitamin D have been associated with alopecia areata (AA), AGA, and telogen effluvium (TE) in some studies, and zinc deficiencies have been associated with TE, hair breakage, and thinning, according to the review. A single-arm vitamin D study showed improved results at 6 months for women with TE, but there was no control group and TE is self-resolving, the authors add. Studies in patients with normal zinc levels at baseline who had AA or hair loss showed significant hair regrowth and increased hair thickness and density, but the trials were a mishmash of controls and no controls and relied on self-perceived hair loss data." - See hair loss supplements at Amazon.com.
  • Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss - JAMA Dermatol 2022 Nov 30 - "Studies of nutritional interventions with the highest-quality evidence showed the potential benefit of Viviscal, Nourkrin, Nutrafol, Lamdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, and pumpkin seed oil. Kimchi and cheonggukjang, vitamin D3, and Forti5 had low-quality evidence for disease course improvement. Adverse effects were rare and mild for all the therapies evaluated" - See hair loss supplements at Amazon.com.
  • Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator Blinded, Randomized Trial - Front Med (Lausanne) 2022 Jul - "The efficacy of topical minoxidil (MX) alone on female pattern hair loss (FPHL) is limited. Combination therapy based on topical MX is currently expected to provide better outcomes ... This study aimed to assess whether the combined therapies including MX plus oral spironolactone (SPT) and MX plus microneedling (MN) have advantages in efficacy and safety over topical MX alone on mild-to-moderate FPHL with normal hormone levels in the blood and regular menstrual cycle ... Topical MX combined with MN is a better choice than either MX plus oral SPT or MX alone for the treatment of mild-to-moderate FPHL patients" - See midoxinil at Amazon.com.
  • New Trial Data Show Hair Growth in More Alopecia Areata Patients - Medscape, 3/26/22 - "Severity of Alopecia Tool (SALT) ... At baseline, patients enrolled in the trial had a mean SALT score of 85.5. After 52 weeks, 39.0% of patients who received 4 mg of baricitinib had at least 80% scalp coverage. Of this group, nearly three out of four (74.1%) had at least 90% scalp coverage ... At baseline, patients enrolled in the trial had a mean SALT score of 85.5. After 52 weeks, 39.0% of patients who received 4 mg of baricitinib had at least 80% scalp coverage. Of this group, nearly three out of four (74.1%) had at least 90% scalp coverage, or a SALT score ≤ 10 ... In patients who received 2 mg of baricitinib, 22.6% had a SALT score ≤ 20 (at least 80% scalp hair coverage) at 52 weeks, and two thirds of that group (67.5%) had at least 90% scalp hair coverage at 52 weeks" - Note: The annual cost of baricitinib is $18,000 for the 2 mg. Maybe if you're Elon Musk.
  • Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro - Skin Pharmacol Physiol 2021 Dec 9 - "These results suggest that metformin can promote hair follicle regeneration in vitro through up-regulation of the hair inductive capability of dermal cells" - See metformin at ReliableRX.
  • Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop - Evid Based Complement Alternat Med 2021 Feb 17 - "Despite minoxidil and finasteride already being approved by the Food and Drug Administration (FDA) for the treatment of hair loss, it is important to identify new and innovative treatments for hair loss, such as looking for a solution in Chinese herbal medicine. One such treatment to consider is BeauTop (BT), whose primary ingredients include Panax japonicus (T.Nees), C.A. Mey. (Araliaceae), Astragalus membranaceus (Fisch) Bunge (Fabaceae), Angelica sinensis (Oliv.) Diels (Apiaceae), Ligustrum lucidum W.T. Aiton (Oleaceae), Rehmannia glutinosa (Gaertn.) DC. (Plantaginaceae), and Eclipta prostrata (L.) L. (Compositae). The aim of this study was to evaluate whether BT can promote hair growth in C57BL/6 mice and to investigate hair coverage, the expression of vascular endothelial growth factor (VEFG), and the numbers of hair follicles in growth phase after oral administration. A total of 12 C57BL/6 mice were divided into two groups: control group and treatment group BT. BT was administered orally as an extract at a volume of 0.6 g/kg. The control group was treated with distilled water. Each group was treated once a day for 12 consecutive days. To observe the expression of VEGF distribution, the number of hair follicles and the hair coverage were examined on days 4, 8, and 12. By comparing the treatment group and control group, we found that VEGF in the BT group on day 8 presented with a higher area percentage than the control group (p value = 0.003). Hair follicle counting results showed that the BT group was significantly higher than the control group on day 8 (p value = 0.031). Furthermore, hair coverage was shown to be significantly increased in the treatment group BT on day 8 (p value = 0.013). Taken together, these results suggest that Chinese medicine (BT) possesses the potential effect of promoting hair growth through VEGF expression. VEGF is considered the most important mediator for the process of angiogenesis involved in hair growth development" - Note:  I don't see where it's sold but I'm sure you can get the main ingredients on Amazon.
  • The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial - J Cosmet Dermatol. 2020 Jan 6 - "Oral hydrolyzed eggshell membrane ingestion was associated with a significant improvement in facial skin appearance in crow's feet in 4 weeks and skin tone in 8 weeks, with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth at 4, 8, and 12 weeks" - [Nutra USA] - See hydrolyzed eggshell membrane at Amazon.com.
  • Is This Treatment the Cure for Hair Loss? - NYT, 8/21/17 - "Then she heard about Harklinikken, a Danish company offering a customized hair extract that’s given only to those who pass a fairly rigorous selection process ... After three months of applying the $88-a-month serum, Ms. Imhof was so excited by the results that she overcame her embarrassment about the subject and posted her own before-and-after photos on Facebook ... Harklinikken (“hair clinic” in Danish) inspires great loyalty. Four out of five users come as referrals from satisfied customers ... After four months of daily application — that is, working the tea-colored tonic into the hair section by section, then letting it sit on the scalp for six hours — most users regain at least 30 percent of lost density, and some as much as 60 percent, according to company figures ... Clients must also use the company’s shampoo, conditioner and styling products, forsaking all others — a psychological as well as a financial buy-in ... It’s also possible that some of Harklinikken’s users are women whose hair would have grown back even if they’d done nothing"
  • A 6-month, randomized, double-blind, placebo-controlled study evaluating the ability of a marine complex supplement to promote hair growth in men with thinning hair - J Cosmet Dermatol. 2016 Aug 9 - "placebo-controlled study was to confirm the beneficial effects of a similar marine complex supplement in adult male subjects with thinning hair (Viviscal® Man ... At Day 90, subjects indicated a significant improvement in three of six quality of life measures as well as a significant overall improvement in quality of life. After 180 days, significant increases were observed for total hair count, total hair density, and terminal hair density (for each, P = 0.001). The investigator assessments revealed significant improvements in terminal and vellus hair count and terminal hair density. Hair pull test results were significantly lower (fewer hairs removed) for study drug vs. placebo at Days 90 (P < 0.05) and 180 (P < 0.01). There were no reports of treatment-emergent adverse events" - [Nutra USA] - See Viviscal® Man at Amazon.com.
  • Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone - Biochem Biophys Res Commun. 2016 Feb 25 - "Dihydrotestosterone (DHT) causes the regression of human hair follicles in the parietal scalp, leading to androgenic alopecia (AGA) ... These results suggest that SFN treatment increases the amount of 3α-HSDs in the liver, accelerates the degradation of blood DHT, and subsequently blocks the suppression of hair growth by DHT" - See sulforaphane at Amazon.com.
  • Nutritional supplement shown to be effective in reducing female hair loss - Nutra USA, 3/19/15 - "the nutritional supplement combines specific omega 3&6 from fish and blackcurrant seed oils with antioxidants (lycopene, vitamin C, and vitamin E) ... after 6 months of treatment, photograph assessment demonstrated a superior improvement in the supplemented group" - See black currant oil at Amazon.com (most health enthusiasts are already taking the rest and most people get too much omega 6 already except for the gamma linolenic acid (GLA) form as in blackcurrant seed  oil).
  • Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial - Evid Based Complement Alternat Med. 2014;2014:549721 - "Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks ... Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men (P < 0.001). Adverse effects were not different in the two groups" - See pumpkin seed oil at Amazon.com.
  • Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model - Biol Pharm Bull. 2014;37(5):755-763 - "the proliferation rates of DHT-treated human hair dermal papilla cells (HHDPCs) and HaCaTs increased by 48% in the ginsenoside F2-treated group and by 12% in the finasteride-treated group" - See ginseng at Amazon.com.
  • Top 4 Foods for Thicker, Shinier Hair - ABC News, 4/29/14 - "Yogurt ... These good bacteria help balance the community of microorganisms that live in our intestines. And a recent study by MIT researchers suggests that probiotics help produce that “healthy glow” we all want, by making skin more radiant and hair more shiny, thick, and lustrous ... The researchers suggest that probiotics decrease inflammation in the top layers of the skin leading to healthier skin and hair ... Vitamin D is essential for keeping your hair growing strong and preventing breakage—it helps keep the follicles healthy, through the growth, shedding, and regrowth of new hairs ... Zinc is a powerful nutrient for hair growth—it helps accelerate the repair of damaged hair follicles, which keeps your hair healthy through all of its growth phases. Zinc deficiency is also associated with hair loss ... The brassicas (cabbage, Brussels sprouts, broccoli, kale) are packed full of healthy nutrients and have been shown to help decrease the risk of heart disease and cancer. They are also rich in phosphatidic acid, little fatty acid messengers involved in cell creation and survival. A study in the Journal of Investigative Dermatology found that phosphatidic acid also promotes hair growth due to its growth-promoting effects on the cells in our hair follicles"
  • Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles - Phytother Res. 2013 Dec 26 - "Crude Panax ginseng has been documented to possess hair growth activity and is widely used to treat alopecia, but the effects of ginsenoside Rg3 on hair growth have not to our knowledge been determined ... Immunohistochemical analysis showed that expression of VEGF was significantly up-regulated by Rg3 in a dose-dependent manner in human DP cells and in mouse hair follicles. In addition, the CD8 and CD34 were also up-regulated by Rg3 in the mouse hair follicles. It may be concluded that Rg3 might increase hair growth through stimulation of hair follicle stem cells and it has the potential to be used in hair growth products" - See ginseng at Amazon.com.
    • Ginsenoside Rg3 ≥98% (HPLC) - Sigma-Aldrich - "Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3.1 Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment.2 It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia"
  • 6 Nutrients for Healthy Hair - ABC News, 10/17/13 - "Iron and zinc ... Vitamin D ... Omega-3 Fatty Acid ... Protein ... Biotin"
  • Topical Agents for Hair Growth Promotion - Medscape, 7/22/13 - "androgenetic alopecia (AGA), i.e., male pattern hair loss and female pattern hair loss ... Melantonin has long been known to modulate hair growth. Animal testing has shown that melatonin stimulates the anagen phase of hair growth.[23] In a double-blind, randomized, placebocontrolled study 40 women with diffuse alopecia (n=28) or AGA (n=12) were treated topically for 6 months with 1 ml daily of 0.1% melatonin-alcohol solution versus vehicle. Trichograms were used to determine efficacy in the frontal and occipital scalp areas. At the end of the study, the AGA group demonstrated a statistically significant increase in anagen hairs in the occiput region compared to placebo (mean 78 to 82 hairs), but no difference was shown with placebo in the frontal area.[24] The group with diffuse alopecia showed a substantial increase in frontal hair. Plasma melatonin levels were elevated under treatment with melatonin, but did not exceed the physiological night peak" - See melatonin at Amazon.com.
  • Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair Re-growth in Testosterone-treated Mice - Phytother Res. 2011 May 2 - "Extracts of red ginseng rhizome showed greater dose-dependent inhibitory effects against testosterone 5α-reductase (5αR) when compared with extracts of the main root. Ginsenoside Ro, the predominant ginsenoside in the rhizome, and ginsenoside Rg(3) , a unique ginsenoside in red ginseng, showed inhibitory activity against 5αR with IC(50) values of 259.4 and 86.1 µm, respectively. The rhizome of P. japonicus, which contains larger amounts of ginsenoside Ro, also inhibited 5αR. Topical administration of extracts of red ginseng rhizomes (2 mg/mouse) and ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. These results suggest that red ginseng rhizomes containing both oleanane- and dammarane-type ginsenosides are a promising raw material for cosmetic use. This is the first report that ginsenoside Ro enhances in vivo hair re-growth based on their inhibitory activity against 5αR in the androgenetic alopecia model" - See ginseng at Amazon.com.
  • Treating Hair Loss Naturally - WebMD - "Daly says he routinely recommends up to 3 mg of biotin daily for his hair loss patients, while Lessman developed a healthy hair, skin, and nails product containing 2 mg of biotin per daily dosage, which he believes is the minimum for healthy hair"
  • Nizoral Shampoo for Hair Lossicon - DermaDoctor.com - "They found that Nizoral increased hair thickness and decreased hair shedding, whereas the zinc pyrithione shampoo had the opposite effect" - See Nizoral Shampoo at drugstore.comicon
  • Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? - Curr Opin Clin Nutr Metab Care. 2010 Sep 4 - "A serum ferritin level of 70 mug/l should be targeted when hair loss is unexplained" - See Slow Fe Slow Release Iron Tablets 90-Count Box at Amazon.com.
  • Snack Size Science: Vitamin E and the quest for thick hair - Nutra USA, 5/5/09 - "The experiments used Carotech’s Tocomin SupraBio ingredient, which contains vitamin E in its tocotrienol forms. Vitamin E comes in eight forms, including four types of tocopherols, and four types of tocotrienols ... According to the company, the Malaysian researchers observed significant hair re-growth of about 42 per cent in the tocotrienol group, with eight volunteers experiencing greater than 50 per cent hair growth. No one in the placebo group experienced any hair growth benefits" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Vitamin E may reverse male pattern baldness: Study - Nutra USA, 4/28/09 - "Volunteers were randomly assigned to the palm tocotrienol complex (total tocotrienol intake of 100 mg) or the placebo (soft gelatin capsule containing 600 mg soy bean oil) ... Hair counts, measured by the counting the number of hairs in a pre-selected 2x2 cm area, were found to significantly increase by an average of 41.8 per cent in the tocotrienol group, with eight volunteers experiencing greater than 50 per cent hair growth ... There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol is the main source found in supplements ... While the majority of research on vitamin E has focused on alpha-Toc, studies into tocotrienols account for less than one per cent of all research into vitamin E" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Effect of Dietary Supplementation With INVERSION(R) Femme on Slimming, Hair Loss, and Skin and Nail Parameters in Women - Adv Ther. 2007 Sep-Oct;24(5):1154-71 - "Weight reduction and slimming were measured after INVERSION Femme was taken for 28 and 58 d. All women showed significant reductions in weight, body fat, and thigh circumference. During the second month of treatment, subjects showed an average 50% reduction in hair loss"
  • Low Iron Could Help Spur Baldness - HealthDay, 5/31/06 - "Iron deficiency is the world's most common nutritional deficiency ... If iron deficiency is detected and treated in the early stages, patients may be able to grow hair more effectively"
  • Hair Loss? It May Be Iron Deficiency - WebMD, 5/17/06 - "whatever the cause of hair loss -- for both women and men -- having too little iron in the blood makes it worse"
  • Flax lignans: a cure for hair loss? - Nutra USA, 5/9/05 - "Ten male sufferers of androgenetic alopecia aged between 20- and 70- years received a 50mg daily dose of SDG in the form of one 250 mg capsule of Acatris’ LinumLife Extra ... eight of the participants reported a modest improvement in their hair loss condition, one reported a great improvement and one reported no effect at all" - See iHerb or Vitacosticon flax products.
  • Reversing Hair Loss? - Dr. Weil, 6/22/04 - "you may be able to prevent further loss and encourage re-growth by including omega-3 fatty acids to your diet"
  • Soy: Prevent Prostate Cancer, Male Baldness? - WebMD, 3/30/04 - "A little-known molecule called equol ... is showing promise as a powerful blocker of a potent male hormone involved in prostate cancer, male baldness, even acne ... Actually, the protective effects occur when two chemicals in soy protein -- genistin and daidzin -- reach the digestive system, Setchell explains. There, they are metabolized to form genistein and daidzein. Daidzein is metabolized once again, to form equol"
  • Laser Comb [Hairmax] May Stimulate Hair Growth - thesandiegochannel.com, 5/8/03 - ""In our clinical trials in Canada, (the comb) does both," said Dr. Martin Unger, plastic surgeon. "We are getting over 97 percent -- sorry, 95 percent -- of the people who are using this are either stopping their hair loss or regrowing hair, and over 75 percent of the patients regrew hair to a significant amount." ... The Hairmax laser comb costs about $700." - See HairMax at drugstore.comicon or Amazon.com.
  • Can I Stop My Hair from Thinning? - Dr. Weil, 9/13/02 - "Make sure you’re getting enough omega-3 fatty acids ... supplement your diet with GLA (gamma-linolenic acid) in the form of black currant oil or evening primrose oil"
  • Natural Treatment for Male Pattern Baldness - New Hope Natural Media, 7/3/02 - "Those with male pattern baldness may increase hair growth by taking a preparation containing saw palmetto (Serenoa repens) and beta-sitosterol ... Conventional medicines used to treat male pattern baldness are designed to block the conversion of testosterone to DHT. Topical application of minoxidil (Rogaine®) and taking oral finasteride (Propecia®) have been shown to inhibit this conversion and to increase hair growth, but both medications have been linked with several adverse side effects, including fast heart rate, headaches, impotence, and decreased libido ... 400 mg of a standardized extract of saw palmetto and 100 mg of beta-sitosterol per day ... After about five months, hair growth in 60% of the men taking the herbal combination had improved compared with their initial evaluation. In contrast, only 11% of those receiving the placebo improved"
  • Nutritional factors and hair loss - Clinical & Experimental Dermatology, 7/02 - "serum ferritin concentrations were a factor in female hair loss ... The role of the essential amino acid, l-lysine in hair loss also appears to be important. Double-blind data confirmed the findings of an open study in women with increased hair shedding, where a significant proportion responded to l-lysine and iron therapy"
  • Monthly Updates - Hair Loss Research, 10/01 - "While finasteride (Propecia/Proscar) decreases serum DHT, it also is thought to increase estrogen which suggests that men over 35 may want to consider using it in conjunction with a systemic aromatase inhibitor such as Chrysin/Piperine (Super Miraforte), Arimidex, or stinging nettle extract, to maximize its hair growth effects and minimize potential side effects (that are listed in the PDR) such as Gynocaemastia (breast enlargement in males), sexual side effects, and an increase in fat deposition. These compounds have been reliably shown to increase testosterone and reduce excess estrogen, resulting in a youthful hormone profile that optimizes immune function and to some degree, body composition"
  • Antiaging Products for Skin, Hair and Nails - Nutrition Science News, 10/00 - "A lack of silicon is known to reduce normal growth and repair of the skin, hair and nails.  However, studies show that silicon supplementation has delivered few benefits. The reason for this in most cases is that a nonbioavailable silicon source has been used. Silicon is a nonmetallic element that is very reactive. It occurs naturally almost exclusively in silicates, the geologic rock-forming minerals. Although silicates are the most abundant materials on earth, they don't provide a bioavailable form of dietary silicon. Moreover, silica, often used as a dietary supplement, is a polymeric silicon-hydroxide-oxide-water complex from hard stone, such as quartz, that has anywhere from two to trillions of silicon atoms, and is also very poorly bioavailable. On the other hand, orthosilicic acid, which consists of only one Si bonded to four hydroxides instead of oxygen, is the form of Si that is found in our bloodstream. Therefore, stabilized orthosilic acid is the only form of supplemental silicon that has been shown conclusively to be bioavailable for humans. Silicates, silica gel, colloidal silica, clays, horsetail (Equisetum arvense) and most foods don't contain the orthosilicic acid form of silicon."
  • Hair Graying and Loss - Nutrition Science News, 10/00 - "Japanese researchers found that topical application of procyanidin-B2 from grape seed and apple extracts activate hair follicles in mice, resulting in increased hair growth. Furthermore, Italian researchers found that a topical preparation containing esculin (an oxolinic acid) from horse chestnut (Aesculus hippocastanum) reduced hair loss and increased circulation to the hair follicles in men and women suffering from hair loss.3 Reduced scalp microcirculation is also one of the factors causing hair loss."
  • Proanthocyanidin Power - Nutrition Science News, 6/00 - "Japanese researchers shaved mice and found that 40 percent of their hair grew back naturally. When a 1 percent solution of any of three proanthocyanidins was applied to the skin, however, between 70 and 80 percent of the hair grew back. Test tube studies confirm that OPCs actually stimulate the hair keratinocytes to produce three times more hair than the controls."
  • Hair Loss- MinSaw-A, Nizoral and Dercos- The bald truth! - By Phil Micans PharmB - "the addition of retinolic acid (the active ingredient in the famous anti-wrinkle skin cream- Retin-A), helps to further stimulate the blood supply on the scalp surface and therefore to the hair follicle"

Other News:

  • Sometimes Hair Loss in Women Can Point to Bigger Health Issues - WebMD. 3/17/23 - "Research shows that women who experience hair loss can also have other medical conditions like diabetes, acne and breast cancer ... By recognizing the signs of hair loss and seeing your dermatologist as soon as possible, you may be able to limit the progression, hold on to the hair you have, and discover any other underlying medical conditions you may have"
  • FDA approves alopecia treatment - Hill. 6/14/22 - "more than 20 percent of patients who received 2 milligrams of Olumiant and more than a third of those who received 4 milligrams achieved 80 percent scalp hair coverage in 36 weeks, compared to only 5 percent who took the placebo"
  • How Best to Fight Hair Loss in Men - WebMD, 2/10/22 - "The top-ranking treatment was dutasteride (Avodart) capsules, at a dose of 0.5 milligrams a day. On average, it produced the biggest increase in total hair count after six months of use. That means men who use it can expect more hair to crop up where there was none, though that includes smaller, "peach fuzz" hairs"
  • JAK Inhibitor Provides Impressive Hair Growth for Patients With Alopecia Areata - Medscape, 10/4/21 - "Baricitinib, an oral inhibitor of Janus kinase (JAK) types 1 and 2, produced substantial rates of hair growth with acceptable tolerability for patients with alopecia areata"
  • Treating the ‘root’ cause of baldness with a dissolvable microneedle patch - Science Daily, 8/11/21 - "The team tested control patches and the cerium-containing ones on male mice with bald spots formed by a hair removal cream. Both applications stimulated the formation of new blood vessels around the mice's hair follicles. However, those treated with the nanoparticle patch showed faster signs of hair undergoing a transition in the root, such as earlier skin pigmentation and higher levels of a compound found only at the onset of new hair development. These mice also had fewer oxidative stress compounds in their skin. Finally, the researchers found that the cerium-containing microneedle patches resulted in faster mouse hair regrowth with similar coverage, density and diameter compared with a leading topical treatment and could be applied less frequently. Microneedle patches that introduce cerium nanoparticles into the skin are a promising strategy to reverse balding for androgenetic alopecia patients"
  • Electric tech could help reverse baldness - Science Daily, 9/19/19 - "Because the devices are powered by the movement of the wearer, they don't require a bulky battery pack or complicated electronics. In fact, they're so low-profile that they could be discreetly worn underneath the crown of an everyday baseball cap ... Small devices called nanogenerators passively gather energy from day-to-day movements and then transmit low-frequency pulses of electricity to the skin. That gentle electric stimulation causes dormant follicles to "wake up." ... Because the electric pulses are incredibly gentle and don't penetrate any deeper than the very outermost layers of the scalp, the devices don't seem to cause any unpleasant side effects. That's a marked advantage over other baldness treatments, like the medicine Propecia, which carries risks of sexual dysfunction, depression and anxiety." - Sounds similar to iRestore.  For what it's worth, iRestore has a higher Amazon rating than Rogaine.
  • Eczema drug restores hair growth in patient with longstanding alopecia - Science Daily, 10/10/18 - "After seven months of dupilumab treatment, the patient had grown a significant amount of the pigmented hair that typically grows on the scalp. Because of a change in her insurance coverage, she had to discontinue dupilumab for a two-month period, during which she noticed shedding of the recently regrown hair. But after she could resume treatment in April 2018, the hair growth resumed and has continued." - Note:  Just like with ruxolitinib, the cost is out of most people's reach.  Dupilumab runs about $3000 per month.  That's cheap compared to ruxolitinib at $12,000.
  • Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR® - Skin Pharmacol Physiol. 2017 Feb 23;30(1):46-54 - "ECOHAIR® spray improved the overall hair volume and appearance; it increased its thickness, induced hair growth, and decreased hair loss. Besides, no adverse local reactions were observed upon treatment with the product ... This study provides scientific support for the clinical use of ECOHAIR® as a treatment to be used in noncicatricial alopecia" - See ECOHAIR®.  I think this is what they're talking about.  If you're using Google Chrome, right click the page and select "Translate to English".  It says $665 with the shipping.  I assume that's Argentina pesos which converts to $43 U.S. dollars but it won't allow you select a country other than Argentina.
  • Drug restores hair growth in patients with alopecia areata - Science Daily, 9/22/16 - "Seventy-five percent of patients with an autoimmune disease that causes hair loss had significant hair regrowth after treatment with ruxolitinib"
  • 5% Minoxidil: Treatment for Female Pattern Hair Loss - Medscape, 2/26/15 - "Recent Phase III clinical trials demonstrated the efficacy of once daily 5% minoxidil foam for treatment of FPHL, where a significant change from baseline in the target area hair count was observed compared to placebo" - See Rogaine at Amazon.com.
  • Autoimmune Drugs May Treat a Form of Baldness - nbcnews.com, 8/17/14 - "The Food and Drug Administration has approved a drug to treat myelofibrosis. It’s called ruxolitinib, or Jakafi. The team tested Jakafi, taken as a pill, in several patients. In three of them, hair grew almost completely back within five months, and the autimmune response was stopped" - Note:  That's the medication that's way out of anyone's price range.  See ruxolitinib at GoodRX.com.
  • Hairless Man Now Hairy, Thanks to Arthritis Drug - WebMD, 6/20/14 - "After three more months taking 15 milligrams a day of the drug, he had a full head of hair and clearly visible eyebrows and eyelashes, as well as facial, armpit and other hair ... Tofacitinib citrate (marketed as Xeljanz) is used to treat rheumatoid arthritis" - NBC News has better pictures of the spectacular results.  It only runs about $42 per 5 mg tablet and you need three per day so about $126 per day.  No problem for the average person.
  • Hair Loss Treatments in the Pipeline - WebMD, 3/31/14 - "Low-level laser light combs and helmets do work, but the devil is in the details, Washenik says. There is not enough evidence to say which product works better. “Convenience and ease of use seem to be the two most important factors,” he says. “The ones that people like best are those where you just sit on the couch and read while wearing a helmet.”" - See laser combs at Amazon.com and iGrow Hand Free Laser LED Light Therapy Hair Regrowth Rejuvenation Brand New - Click here for the press release.
  • Drug used to treat glaucoma actually grows human hair - Science Daily, 10/26/12 - "Given that the drug is already approved for human use and its safety profile is generally understood, this looks like a promising discovery that has been right in front of our eyes the whole time. On to the front of our scalp"
  • Bald-breaker! - The Daily, 3/22/12 - "the protein prostaglandin D2 was found at triple the level in the bald patches of skin in both men and male mice ... when added to a single hair in a lab dish, the protein bound itself to the hair’s cells and stunted its growth ... Over the next two years, there’ll very likely be a product based on prostaglandins to treat hair loss"
  • Latisse for your dome? Drug thickens thin hair - MSNBC, 11/14/11 - "The appeal of using Latisse for hair loss is its ease and convenience, as it seems to only require one drop to the affected area once a day ... The major drawback: It's expensive. Each 2-ounce bottle costs $100 to $150 — and some patients will run through two or three bottles a month"
  • Regrowing hair: Researchers may have accidentally discovered a solution - Science Daily, 2/16/11 - "a short-duration treatment with this compound causes an astounding long-term hair regrowth in chronically stressed mutant mice ... the researchers had been using mice that were genetically altered to overproduce a stress hormone called corticotrophin-releasing factor, or CRF. As these mice age, they lose hair and eventually become bald on their backs, making them visually distinct from their unaltered counterparts. The Salk Institute researchers had developed the chemical compound, a peptide called astressin-B, and described its ability to block the action of CRF. Stenzel-Poore had created an animal model of chronic stress by altering the mice to overproduce CRF ... researchers injected the astressin-B into the bald mice to observe how its CRF-blocking ability affected gastrointestinal tract function. The initial single injection had no effect, so the investigators continued the injections over five days to give the peptide a better chance of blocking the CRF receptors. They measured the inhibitory effects of this regimen on the stress-induced response in the colons of the mice and placed the animals back in their cages with their hairy counterparts ... About three months later, the investigators returned to these mice to conduct further gastrointestinal studies and found they couldn't distinguish them from their unaltered brethren. They had regrown hair on their previously bald backs" - Note:  To the best of my knowledge there's nothing non-experimental on the market, either conventional or alternative, that inhibits CRF.  If there were people would be taking it to reduce cortisol.
  • Drugs for hair loss and benign prostatic hyperplasia may result in loss of libido, erectile dysfunction in men - Science Daily, 1/11/11 - "5a-reductase inhibitors (5a-RIs), while improving urinary symptoms in patients with benign prostatic hyperplasia (BPH) and possible hair loss prevention, produces significant adverse effects in some individuals including loss of libido, erectile dysfunction (ED), ejaculatory dysfunction and potential depression" - Note:  That goes back and forth.  One study claimed that finasteride improved sex after after six months of taking it.  Regarding gynaecomastia, if you're taking low dose letrozole to increase testosterone and to prevent aromatization it many also help prevent gynaecomastia.
  • Treatment Found To Reverse Hair Loss - Science Daily, 6/11/07 - "one of each pair of twins was given 0.5 mg/day of the medication, the other receiving a placebo ... After both 6 and 12-month intervals, hair loss was found to not only have been halted in twins using dutasteride, but hair growth was actively improved" - Note:  Dutasteride is Avodart®.
  • Grasping at strands for baldness remedies - USA Today, 3/18/07 - "So where does the laser comb fit in? Leavitt points to the six-month study reviewed by the FDA that shows men who used the comb grew an average of 19 more "terminal" (thick, rather than thin) hairs per square centimeter than those who used sham devices. That's a "medically significant" amount, he says, though the average healthy scalp has 160 to 260 hairs per square centimeter" - See the HairMax at Amazon.com.
  • Drug May Fight Women's Hair Loss, Too - WebMD, 3/20/06 - "Propecia, a drug used to treat male hair loss, may help fix women's hair loss when taken with birth control pills"
  • Cancer Research Leads To Possible Baldness Cure - In Mice - Intelihealth, 2/16/01 - "The VEGF-enhanced mice regrew hair quicker, and, better yet, researchers found that their hair follicles - the structures at the roots of hairs - were 30 percent wider. . . "By overall volume, the hair was about 70 percent thicker" than in the normal mice, Detmar said, adding, "To my knowledge, no one has been able to make hair thicker" previously."
  • Hair Loss and Thyroid Disease - About.com, 6/10/99 - "In a recent study, Dr Hugh Rushton, a professor at Portsmouth University, also found that 90 percent of women with thinning hair were deficient in iron and the amino acid lysine"