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Home > Anti-aging Research > Saw Palmetto

Saw Palmetto

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  • Pondering Prostate Problems? - Dr. Weil, 4/28/06 - "All told, this study shouldn't discourage men with mild-to-moderate BPH from using saw palmetto. I still recommend taking 160 mg of a standardized extract twice a day; this should help reduce the size of the gland in about four to six weeks"
  • Study Questions Use of Popular Prostate Treatment - ABC News, 2/8/06 - "At the end of one year, the men taking saw palmetto showed no significant improvement in their symptoms ... It's possible that other preparations of saw palmetto might be effective, even though the one used in this study was not"
  • Relieve Common Men’s Condition with Saw Palmetto Extract - Healthwell Exchange Daily News, 9/16/04 - "Comparison trials found its effects to be similar to those of finasteride and tamsulosin ... however, while some men using the standard medications experienced sexual dysfunction as a side effect, men using the herbal extract did not" - See iHerb saw palmetto products.
  • Saw Palmetto Extract Effective in Treating Chronic Prostatitis - Medscape, 4/28/03 - "Permixon, a compound extracted from the fruit of the American dwarf palm tree Serona repens, also known as saw palmetto, appears to improve symptoms of chronic prostatitis/chronic pelvic pain syndrome ... Seventy-five percent of the patients who received Permixon had at least mild improvement in symptoms compared with 20% of the control group. Similarly, 55% of patients who received Permixon reported moderate or marked improvement compared with 16% of the control group ... In the control group, PSA did not differ from baseline. However, the group taking Permixon experienced median decreases from baseline PSA of 22% after 6 weeks" - See iHerb saw palmetto products.
  • Herbal Remedies Can Aid Prostate Health - WebMD, 2/4/03 - "One in three men are treated for BPH with surgery or, more commonly, prescription drugs such as Flomax or Proscar. But growing research suggests that some symptoms may be treated as effectively with over-the-counter herbal remedies -- sometimes less expensively and thus far, with no reported side effects. What's more, some of these treatments claim they may help prevent prostate cancer, the second leading cause of cancer death in men"
  • Natural Treatment for Male Pattern Baldness - New Hope Natural Media, 7/3/02 - "Those with male pattern baldness may increase hair growth by taking a preparation containing saw palmetto (Serenoa repens) and beta-sitosterol ... Conventional medicines used to treat male pattern baldness are designed to block the conversion of testosterone to DHT. Topical application of minoxidil (Rogaine®) and taking oral finasteride (Propecia®) have been shown to inhibit this conversion and to increase hair growth, but both medications have been linked with several adverse side effects, including fast heart rate, headaches, impotence, and decreased libido ... 400 mg of a standardized extract of saw palmetto and 100 mg of beta-sitosterol per day ... After about five months, hair growth in 60% of the men taking the herbal combination had improved compared with their initial evaluation. In contrast, only 11% of those receiving the placebo improved"


  • 5-alpha reductase inhibitors and prostate cancer mortality among men with regular access to screening and health care - Cancer Epidemiol Biomarkers Prev 2022 Mar 4 - "Men using 5-ARIs underwent more PSA testing, prostate exams and biopsies. Over 20 years of follow-up, 509 men developed lethal disease (metastases or prostate cancer death). Among men initially free from prostate cancer, 5-ARI use was not associated with developing lethal disease (HR 1.02, 0.71-1.46), but was associated with reduced rates of overall and localized disease (HR 0.71, 0.60-0.83). Among men diagnosed with prostate cancer, there was no association between 5-ARI use and cancer-specific (HR 0.78, 0.48-1.27) or overall survival (HR 0.88" - See saw palmetto at Amazon.com.
  • Hexanic Extract of Serenoa repens (Permixon ®): A Review in Symptomatic Benign Prostatic Hyperplasia - Drugs Aging 2022 Mar 3 - "The hexanic extract (HE) of Serenoa repens (Permixon®) is indicated for the symptomatic treatment of benign prostatic hyperplasia (BPH). The drug is the n-hexane lipidosterolic extract of the American dwarf palm tree (also known as saw palmetto). The anti-inflammatory activity of HE S. repens has been demonstrated in vitro, in vivo and in men with prostatic inflammation. In randomized clinical trials, the efficacy of HE S. repens was similar to that of an α-blocker in terms of improving voiding and storage symptoms, increasing urinary flow rate and reducing prostate volume in men with BPH. HE S. repens was also as effective as 5α-reductase inhibitors and/or α-blockers at improving lower urinary tract symptoms (LUTS) and quality of life (QOL) in real-world observational studies. HE S. repens was generally well tolerated, with a lesser impact on male sexual function compared with other available therapies. Thus, HE S. repens is a useful option for the treatment of symptomatic BPH"
  • Fatty Acid and Phytosterol Content of Commercial Saw Palmetto Supplements - Nutrients 2013, 5(9), 3617-3633 - "The variation in the efficacy in these trials may be a result of differences in the putative active components, fatty acids and phytosterols, of the saw palmetto supplements ... Liquid saw palmetto supplements contained significantly higher (p < 0.05) concentrations of total fatty acids (908.5 mg/g), individual fatty acids, total phytosterols (2.04 mg/g), and individual phytosterols, than the other supplement categories. Powders contained significantly higher (p < 0.05) concentrations of total fatty acids than tinctures, which contain negligible amounts of fatty acids (46.3 mg/g) and phytosterols (0.10 mg/g). Our findings suggest that liquid saw palmetto supplements may be the best choice for individuals who want to take a saw palmetto supplement with the highest concentrations of both fatty acids and phytosterols" - Note:  See the table.  It was a no contest.  According to Nutra USA, Doctor's Best had the highest fatty acid content of the products tested.
  • Saw Palmetto Extract Enhances Erectile Responses by Inhibition of Phosphodiesterase 5 Activity and Increase in Inducible Nitric Oxide Synthase Messenger Ribonucleic Acid Expression in Rat and Rabbit Corpus Cavernosum - Urology. 2013 Apr 23 - "The results suggest that SPE may have potential application value for the prevention or treatment of erectile dysfunction through an increase in iNOS mRNA expression and inhibition of PDE5 activity in corpus cavernosum smooth muscles" - See saw palmetto products at iHerb.
  • Androgen-independent Effects of Serenoa repens Extract (Prostasan®) on Prostatic Epithelial Cell Proliferation and Inflammation - Phytother Res. 2011 Jun 8 - "Prostasan® inhibited epidermal growth factor (EGF) and lipopolysaccharide (LPS) induced proliferation of the prostatic epithelial, androgen independent cell line PC-3. At effective concentrations of 50 µg/mL, Prostasan® partly displaced EGF from EGF receptor (EGFR) but fully blocked EGF-induced cell proliferation of PC-3 cells. Similarly, Prostasan® inhibited LPS-induced proliferation of PC-3 cells without affecting LPS activation of the NFĸB pathway via toll-like receptor-4 (TLR-4). Additionally, Prostasan® reduced the constitutive secretion of monocyte chemotactic protein-1 (MCP-1), the LPS-induced secretion of IL-12 and inhibited MCP-1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) production in the presence of LPS on PC-3 cells. Taken together, our results suggest that S. repens extracts, in addition to other reported effects on BPH development and prostatitis, inhibits EGF-dependent growth and proinflammatory responses of the prostate epithelial cells" - See Prostasan at Amazon.com.
  • Characterizing components of the Saw Palmetto Berry Extract (SPBE) on prostate cancer cell growth and traction - Biochem Biophys Res Commun. 2008 Dec 4 - "Saw Palmetto Berry Extract (SPBE) ... The results show for the first time the potential of SPBE, beta-sitosterol and stigmasterol as potential anti-tumor agents" - See beta sitosterol at Amazon.com and saw palmetto at Amazon.com.