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Prolactin

Specific Recommendations (to lower prolactin):

• pygeum / St. John's wort

Alternative News:

• Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat - J Psychopharmacol. 2000;14(4):360-3 - "LI 160 also lowered plasma prolactin and prevented the increase in plasma prolactin following haloperidol administration"
• Saving Yourself from AGE - Life Enhancement Magazine, 8/00 - with American Ginseng, "The researchers found a reduction in plasma prolactin, a hormone connected with passive "nesting" behavior, suggesting that this may play a role in the ability of American ginseng to stimulate sexual activity in the male rat."
• Make Spring Come Sooner - Life Enhancement Magazine, 4/98 - "After administration of 5-HTP, the cortisol level significantly increased and the prolactin level significantly decreased. High levels of prolactin have been shown to reflect many depressive states."
• 5-HTP SeroTonic™ & 5-HTP Slim™ May Help Make Spring Come Sooner - Life Enhancement Magazine, 4/98 - "High levels of prolactin have been shown to reflect many depressive states ... 5-HTP reduces prolactin"
• Study 20 - The Hypericum Homepage - "Both serum-cortisol and serum-prolactin were lowered significantly after three weeks of treatment with hypericum extract in male rats."
• Pyridoxine (Vit. B6) decreases opioids-induced hyperprolactinemia - Horm Metab Res. 1985 Jan;17(1):46-7
• Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise - N Engl J Med. 1982 Aug 12;307(7):444-5
• Inhibition of prolactin by pyridoxine - Am J Obstet Gynecol. 1979 Sep 15;135(2):280-1
• Effects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male rats - J Pharm Sci. 1979 Sep;68(9):1179-81 - "Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise"

Other Information:

• Bromocriptine (Parlodel®) - International Anti-aging Systems
• Men's sexual desire linked to prolactin levels - NBC News.com, 11/20/13 - "researchers looked at nearly 3,000 European men ages 40 to 79, and measured their testosterone and prolactin levels, body mass indexes (BMIs), and blood cholesterol and sugar levels ... low prolactin was linked to several signs of poor sexual health, as well psychological health. Men with levels of prolactin that were lower than average, although still within the normal range, were more likely than men with higher levels to say their sexual function was getting worse, particularly their enjoyment of orgasm. They also had more symptoms of depression ... Low prolactin was also associated with higher BMI and blood sugar, lower levels of physical activity, and generally feeling unhealthier ... Studies have found that high prolactin levels in men are linked to low sexual desire and erectile dysfunction, and men suffering from such conditions are sometimes tested for high prolactin levels ... Some previous research supports the new finding, the researchers said. Two animal studies have shown that using drugs to increase prolactin levels in rats boosted their sexual behavior"
• Evaluation and Treatment of Male Sexual Dysfunction  - American Association of Clinical Endocrinologists and The American College of Endocrinology - "increased prolactin levels may also cause erectile problems, even in the presence of a normal testosterone level."
• Erectile Dysfunction / Impotence - Prostate Health Guide - U. of Maryland Medicine - "Hormonal abnormalities such as increased prolactin (a hormone produced by the anterior pituitary gland), steroid abuse by body-builders, too much or too little thyroid hormone, and hormones administered for prostate cancer may cause impotence. Rarely is low testosterone responsible for impotence"
• Prolactin blocks oncogene associated with poor prognosis in breast cancer - Science Daily, 2/3/10
• Hormone Prolactin Reduces Fat Metabolism - Science Daily, 4/2/09
• Aripiprazole Reverses Antipsychotic-Induced Hyperprolactinemia - Medscape, 10/1/07
• Antipsychotic Treatment: When to Measure Prolactin - Clinical Psychiatry News, 5/05
• Antipsychotic Medications Vary In Effect On Plasma Prolactin Levels - Doctor's Guide, 2/10/04
• Cabergoline May Be Safely Withdrawn From Select Patients With Hyperprolactinomas - Doctor's Guide, 11/21/03
• Aripiprazole Benefits Are Sustained Over Time - Clinical Psychiatry News, 5/03 - "Its principal advantage over other atypical agents remains a superior side effect profile; no apparent difference in efficacy exists ... It's not the new clozapine (Clozaril) ... it seems clearly superior in areas that have been problematic, notably weight gain, effects on blood lipids and glucose, and prolactin elevation ... in fact, they lost weight overall, with the heaviest patients losing most ... Pooled data from short-term clinical studies showed a mean decline of 57% in serum prolactin"
• Prolactin Not A Pro-Inflammatory In Polymyalgia Rheumatica - Doctor's Guide, 4/26/02
• Antipsychotic-Induced Hyperprolactinemia May Have Reproductive And Other Clinical Morbidities - Doctor's Guide, 8/8/01
• Elevated Prolactin Linked To Breast Cancer - Life Extension Magazine, 6/99
• Laboratory Investigations of Erectile Dysfunction - WebMD
• Dostinex Launched for Pituitary Gland Disorders - Doctor's Guide, 3/18/97