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Chrysin

Specific Recommendations:

• chrysin at Amazon.com
• Chrysin products at iHerb

Related Topics:

• I3C / Aromatization / Testosterone Replacement / HRT / DIM

News & Research:

• Chrysin: Is It An Effective Aromatase Inhibitor? - vrp.com - "Unfortunately, there does not appear to be any effective natural inhibitor of aromatase"
• Replenish Testosterone Naturally - Life Extension Magazine, 1/00 - "chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). The study tested the aromatase-inhibiting effects of these natural flavonoids (such as genistein, rutin, tea catechins, etc.) in human fat cell cultures. Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug ... Chrysin, for example, is a potent antioxidant that possesses vitamin-like effects in the body ... Chrysin was shown to produce anti-anxiety effects comparable with diazepam, but without sedation and muscle relaxation. In other words, chrysin produced a relaxing effect in the brain, but with no impairment of motor activity ... chrysin can reduce anxiety without inducing the common side-effects associated with benzodiazepine drugs ... chrysin displayed potent anti-anxiety effects in rats, but did not interfere with cognitive performance ... chrysin selectively inhibits anxiety in the brain but, unlike diazepam, does not induce the cognitive impairment ... Chrysin may therefore offer libido-enhancing effects in the aging male by:  Increasing free testosterone, - Decreasing excess estrogen, - Producing a safe anti-anxiety effect"
• Male Hormone Modulation Therapy  - Life Extension Magazine, 11/99
• Monthly Updates - Hair Loss Research, 10/01 - "While finasteride (Propecia/Proscar) decreases serum DHT, it also is thought to increase estrogen which suggests that men over 35 may want to consider using it in conjunction with a systemic aromatase inhibitor such as Chrysin/Piperine (Super Miraforte), Arimidex, or stinging nettle extract, to maximize its hair growth effects and minimize potential side effects (that are listed in the PDR) such as Gynocaemastia (breast enlargement in males), sexual side effects, and an increase in fat deposition. These compounds have been reliably shown to increase testosterone and reduce excess estrogen, resulting in a youthful hormone profile that optimizes immune function and to some degree, body composition"

Abstracts:

• Lycopene and Chrysin through Mitigation of Neuroinflammation and Oxidative Stress Exerted Antidepressant Effects in Clonidine-Induced Depression-like Behavior in Rats - J Diet Suppl 2021 Oct 11;1-20 - "Depression is a severely debilitating psychiatric disorder that influences more than 15% of the population worldwide. It has been demonstrated that it is associated with a high risk of developing other diseases such as cardiovascular diseases, diabetes, stroke, epilepsy, and cancer ... The rats in group 1 served as a control. Group 2 received lycopene only. Group 3 was provided chrysin only. Group 4 was administered clonidine and served as the model. Group 5 was offered lycopene and clonidine. Group 6 was administered chrysin and clonidine. Group 7 was given FLX and clonidine and represented the standard ... The current research demonstrates that lycopene and chrysin have an auspicious antidepressant effect against clonidine that provoked behavioral hopelessness in rats. Manipulating oxidative stress, inflammation, and apoptosis may partially represent the corrective mechanism for the neuroprotective actions against the depressive effect of clonidine" - See lycopene at Amazon.com and iHerb and  chrysin at Amazon.com.
• Chrysin Protects against Memory and Hippocampal Neurogenesis Depletion in D-Galactose-Induced Aging in Rats - Nutrients. 2020 Apr 16 - "The interruption of hippocampal neurogenesis due to aging impairs memory. The accumulation of D-galactose (D-gal), a monosaccharide, induces brain aging by causing oxidative stress and inflammation, resulting in neuronal cell damage and memory loss. Chrysin, an extracted flavonoid, has neuroprotective effects on memory ... Male Sprague-Dawley rats received either D-gal (50 mg/kg) by i.p. injection, chrysin (10 or 30 mg/kg) by oral gavage, or D-gal (50 mg/kg) and chrysin (10 or 30 mg/kg) for 8 weeks. Memory was evaluated using novel object location (NOL) and novel object recognition (NOR) tests. Hippocampal neurogenesis was evaluated using Ki-67, 5-bromo-2'-deoxyuridine (BrdU), and doublecortin (DCX) immunofluorescence staining to determine cell proliferation, cell survival, and number of immature neurons, respectively. We found that D-gal administration resulted in memory impairment as measured by NOL and NOR tests and in depletions in cell proliferation, cell survival, and immature neurons. However, co-treatment with chrysin (10 or 30 mg/kg) attenuated these impairments. These results suggest that chrysin could potentially minimize memory and hippocampal neurogenesis depletions brought on by aging" - See chrysin at Amazon.com and chrysin at iHerb.com.
• Chrysin Suppresses IL-6-Induced Angiogenesis via Down-regulation of JAK1/STAT3 and VEGF: An in Vitro and in Ovo Approach - J Agric Food Chem. 2010 May 5 - "Chrysin may provide new therapeutic potential for IL-6-induced pathological angiogenesis"
• Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB - Cancer Lett. 2010 Feb 2 - "In the present study, we found that, pretreatment with chrysin greatly sensitized various human cancer cells to tumor necrosis factor-alpha (TNFalpha)-induced apoptosis"
• Inhibition of aromatase activity by flavonoids - Arch Pharm Res. 1999 Jun;22(3):309-12
• Flavonoid inhibition of aromatase enzyme activity in human preadipocytes - J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8 - "Chrysin, the most potent of the naturally-occurring flavonoids, was similar in potency and effectiveness to AG, a pharmaceutical aromatase inhibitor used clinically in cases of estrogen-dependent carcinoma."
• Inhibition of human estrogen synthetase (aromatase) by flavones - Science. 1984 Sep 7;225(4666):1032-4 - "7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450"