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Evening Primrose (Oenothera biennis)

Specific Recommendations:

• Evening primrose oil at Amazon.com

News & Research:

• GLA (Gamma-Linolenic Acid) - The Natural Pharmacist
• Can I Stop My Hair from Thinning? - Dr. Weil, 9/13/02 - "Make sure you’re getting enough omega-3 fatty acids ... supplement your diet with GLA (gamma-linolenic acid) in the form of black currant oil or evening primrose oil"
• Healing Skin and Coat Conditions - Nutrition Science News, 10/01
• PUFAs for Bone Growth and Repair - Nutrition Science News, 3/01
• Ten Things You Can Do To Stop Hair Loss With Thyroid Disease - About.com, 6/10/99 (talks about EPO about two thirds down)

Related Sites:

• Evening primrose seed extract rich in polyphenols modulates the invasiveness of colon cancer cells by regulating the TYMS expression - Food Funct 2022 Oct 14 - "The inhibition of metastasis correlated with a decrease in thymidylate synthetase (TYMS), which has recently been associated with metastatic phenotype development. Our results indicate that the EPE might be an effective anticancer agent in suppressing colon cancer metastasis regardless of the invasiveness cause. Based on these findings, we concluded that the used EPE extract rich in polyphenols inhibits cell invasion by TYMS downregulation" - See evening primrose oil at Amazon.com.
• Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis - Adv Ther. 2014 Jan 17 - "Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) contains high amounts of GLA. Therefore, this study investigated whether EPO supplementation results in an increase in plasma GLA and its metabolite dihomo-gamma-linolenic acid (DGLA) correlating with clinical improvement of AD, assessed by the SCORing Atopic Dermatitis (SCORAD) index ... The clinical disease activity under EPO treatment correlates with the individual increase in plasma GLA levels. Thus, the results of this pilot study indicate that an increase in plasma GLA might be used as predictive parameter for responsiveness of AD to EPO therapy"