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Anti-aging Research > Nicotinamide mononucleotide
Nicotinamide mononucleotide
Specific Recommendations:
News & Research:
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NMN and NR: How These NAD+ Precursors Measure Up - elysiumhealth.com -
"NMN is a precursor to NAD+, or nicotinamide adenine
dinucleotide, meaning it becomes NAD+ through a series of chemical
transformations ... However, NMN is like a large bed that movers are trying to
get through a door: It doesn’t enter the cell easily. One way for NMN to enter
the cell is for it to chemically transform into another molecule (called
nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name
for itself as a highly efficient precursor to NAD+ and can enter the cell as is.
NMN, meanwhile, sometimes becomes NR before entering the cell, where it
chemically transforms back to NMN and then ultimately becomes NAD+"
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What’s the Difference Between NAD+ and NADH? - Elysiumhealth.com -
"When NAD+ is converted to NADH, it gains two things:
First, a charged hydrogen molecule (H+) and next, two electrons. As electrons
are negatively charged, the combination of the positively charged NAD+ and H+,
coupled with two electrons, effectively cancel each other out and neutralize the
resulting NADH molecule. This is why NADH does not have a "+" sign next to it.
The charge of a molecule informs how it interacts with other molecules. For
example, NADH can’t do what NAD+ does, and vice versa."
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Mohs Surgeons Favor
Nicotinamide for Chemoprevention in Survey - Medscape, 4/20/21 -
"Approximately three-quarters of Mohs surgeons recommended nicotinamide for
prevention of keratinocyte carcinoma" - See
nicotinamide at Amazon.com.
Abstracts:
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Nicotinamide mononucleotide
supplementation protects the intestinal function in aging mice and D-galactose
induced senescent cells - Food Funct 2022 Jun 9 -
"The nicotinamide adenine dinucleotide (NAD+) level shows a temporal decrease
during the aging process, which has been deemed as an aging hallmark.
Nicotinamide mononucleotide (NMN), a key NAD+ precursor, shows the potential to
retard the age-associated functional decline in organs ... The above data
demonstrated the potential of NMN in ameliorating the structural and functional
decline in the intestine during aging" - See
nicotinamide mononucleotide at Amazon.com.
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Preclinical and clinical
evidence of NAD + precursors in health, disease, and ageing - Mech Ageing
Dev 2021 Sep 10 - "NAD+ is a fundamental molecule in
human life and health as it participates in energy metabolism, cell signalling,
mitochondrial homeostasis, and in dictating cell survival or death. Emerging
evidence from preclinical and human studies indicates an age-dependent reduction
of cellular NAD+, possibly due to reduced synthesis and increased consumption.
In preclinical models, NAD+ repletion extends healthspan and / or lifespan and
mitigates several conditions, such as premature ageing diseases and
neurodegenerative diseases. These findings suggest that NAD+ replenishment
through NAD+ precursors has great potential as a therapeutic target for ageing
and age-predisposed diseases, such as Alzheimer's disease. Here, we provide an
updated review on the biological activity, safety, and possible side effects of
NAD+ precursors in preclinical and clinical studies. Major NAD+ precursors
focused on by this review are nicotinamide riboside (NR), nicotinamide
mononucleotide (NMN), and the new discovered dihydronicotinamide riboside (NRH)"
- See nicotinamide riboside at Amazon.com
and nicotinamide mononucleotide at Amazon.com.
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Nicotinamide mononucleotide
supplementation enhances aerobic capacity in amateur runners: a randomized,
double-blind study - See nicotinamide
mononucleotide at Amazon.com - J Int Soc Sports Nutr 2021 Jul 8 -
"Recent studies in rodents indicate that a combination
of exercise training and supplementation with nicotinamide adenine dinucleotide
(NAD+) precursors has synergistic effects. However, there are currently no human
clinical trials analyzing this ... This study investigates the effects of a
combination of exercise training and supplementation with nicotinamide
mononucleotide (NMN), the immediate precursor of NAD+, on cardiovascular fitness
in healthy amateur runners ... The participants were randomized into four
groups: the low dosage group (300 mg/day NMN), the medium dosage group (600
mg/day NMN), the high dosage group (1200 mg/day NMN), and the control group
(placebo) ... NMN increases the aerobic capacity of humans during exercise
training, and the improvement is likely the result of enhanced O2 utilization of
the skeletal muscle" - See nicotinamide mononucleotide at Amazon.com.
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NAD + and NAFLD - Caution,
Causality, and Careful Optimism - J Physiol 2021 May 1 -
"The prevalence of non-alcoholic fatty liver disease
(NAFLD) is increasing worldwide, and new treatments are direly needed.
Nicotinamide adenine dinucleotide (NAD+ ) has been proposed as a potential
target to prevent and reverse NAFLD. NAD+ is an important redox factor for
energy metabolism and is used as a substrate by a range of enzymes, including
sirtuins (SIRT), which regulates histone acetylation, transcription factor
activity and mitochondrial function. NAD+ is also a precursor for reduced
nicotinamide adenine dinucleotide phosphate (NADPH), which is an important
component of the antioxidant defense system. NAD+ precursors such as
nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are available
as over-the-counter dietary supplements, and oral supplementation with these
precursors increases hepatic NAD+ levels and prevent hepatic lipid accumulation
in pre-clinical models of NAFLD. Moreover, NAD+ precursors were found to improve
hepatic mitochondrial function and decrease oxidative stress in pre-clinical
NAFLD models. NAD+ repletion also prevents NAFLD progression to non-alcoholic
steatohepatitis (NASH), as NAD+ precursor supplementation is associated with
decreased hepatic stellate cell activation, and decreased fibrosis. However,
initial clinical trials have only shown modest effects when NAD+ precursors were
administrated to people with obesity. We review the available pre-clinical
investigations of NAD+ supplementation for targeting NAFLD, and discuss how data
from the first clinical trials can be reconciled with observations from
preclinical research" - See nicotinamide adenine dinucleotide at Amazon.com.
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Effect of oral
administration of nicotinamide mononucleotide on clinical parameters and
nicotinamide metabolite levels in healthy Japanese men - Endocr J. 2019 Nov
2 - "the oral administration of NMN was found to be
feasible, implicating a potential therapeutic strategy to mitigate
aging-related disorders in humans" - See
nicotinamide mononucleotide at Amazon.com.
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