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Home > Anti-aging Research > Nicotinamide mononucleotide

Nicotinamide mononucleotide

Specific Recommendations:

News & Research:

  • NMN and NR: How These NAD+ Precursors Measure Up - elysiumhealth.com - "NMN is a precursor to NAD+, or nicotinamide adenine dinucleotide, meaning it becomes NAD+ through a series of chemical transformations ... However, NMN is like a large bed that movers are trying to get through a door: It doesn’t enter the cell easily. One way for NMN to enter the cell is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name for itself as a highly efficient precursor to NAD+ and can enter the cell as is. NMN, meanwhile, sometimes becomes NR before entering the cell, where it chemically transforms back to NMN and then ultimately becomes NAD+"
  • What’s the Difference Between NAD+ and NADH? - Elysiumhealth.com - "When NAD+ is converted to NADH, it gains two things: First, a charged hydrogen molecule (H+) and next, two electrons. As electrons are negatively charged, the combination of the positively charged NAD+ and H+, coupled with two electrons, effectively cancel each other out and neutralize the resulting NADH molecule. This is why NADH does not have a "+" sign next to it. The charge of a molecule informs how it interacts with other molecules. For example, NADH can’t do what NAD+ does, and vice versa."
  • Mohs Surgeons Favor Nicotinamide for Chemoprevention in Survey - Medscape, 4/20/21 - "Approximately three-quarters of Mohs surgeons recommended nicotinamide for prevention of keratinocyte carcinoma" -  See nicotinamide at Amazon.com.

Abstracts:

  • Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study - See nicotinamide mononucleotide at Amazon.com - J Int Soc Sports Nutr 2021 Jul 8 - "Recent studies in rodents indicate that a combination of exercise training and supplementation with nicotinamide adenine dinucleotide (NAD+) precursors has synergistic effects. However, there are currently no human clinical trials analyzing this ... This study investigates the effects of a combination of exercise training and supplementation with nicotinamide mononucleotide (NMN), the immediate precursor of NAD+, on cardiovascular fitness in healthy amateur runners ... The participants were randomized into four groups: the low dosage group (300 mg/day NMN), the medium dosage group (600 mg/day NMN), the high dosage group (1200 mg/day NMN), and the control group (placebo) ... NMN increases the aerobic capacity of humans during exercise training, and the improvement is likely the result of enhanced O2 utilization of the skeletal muscle" - See nicotinamide mononucleotide at Amazon.com.
  • NAD + and NAFLD - Caution, Causality, and Careful Optimism - J Physiol 2021 May 1 - "The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide, and new treatments are direly needed. Nicotinamide adenine dinucleotide (NAD+ ) has been proposed as a potential target to prevent and reverse NAFLD. NAD+ is an important redox factor for energy metabolism and is used as a substrate by a range of enzymes, including sirtuins (SIRT), which regulates histone acetylation, transcription factor activity and mitochondrial function. NAD+ is also a precursor for reduced nicotinamide adenine dinucleotide phosphate (NADPH), which is an important component of the antioxidant defense system. NAD+ precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are available as over-the-counter dietary supplements, and oral supplementation with these precursors increases hepatic NAD+ levels and prevent hepatic lipid accumulation in pre-clinical models of NAFLD. Moreover, NAD+ precursors were found to improve hepatic mitochondrial function and decrease oxidative stress in pre-clinical NAFLD models. NAD+ repletion also prevents NAFLD progression to non-alcoholic steatohepatitis (NASH), as NAD+ precursor supplementation is associated with decreased hepatic stellate cell activation, and decreased fibrosis. However, initial clinical trials have only shown modest effects when NAD+ precursors were administrated to people with obesity. We review the available pre-clinical investigations of NAD+ supplementation for targeting NAFLD, and discuss how data from the first clinical trials can be reconciled with observations from preclinical research" - See nicotinamide adenine dinucleotide at Amazon.com.
  • Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men - Endocr J. 2019 Nov 2 - "the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans" - See nicotinamide mononucleotide at Amazon.com.