Recent Longevity News for the seven days ending 2/18/09.  You should consult your doctor if you are taking any medications.

Vitamin C-rich foods may boost artery health - Nutra USA, 2/17/09 - "increased intakes of vitamin C and fruit and berries were associated with less thickening of the carotid artery ... one mg per decilitre increase in blood vitamin C levels was linked to a 4.1 and 4.0 mmHg in systolic and diastolic blood pressures" - [Abstract] - See vitamin C products at Amazon.com.

Taurine: Key To The Visual Toxicity Of An Anti-epileptic Drug For Children? - Science Daily, 2/17/09 - "Vigabatrin (Sabril), first intention molecule for the treatment of epilepsy in children, in many cases produces secondary effects that lead to an irreversible loss of vision ... vigabatrin provokes a marked decrease in the blood level in an amino acid, taurine, resulting in a degeneration of the retina cells induced by light. The researchers therefore suggest that exposure to light should be reduced and a taurine-rich diet introduced in order to curb immediately these secondary effects in children undergoing treatment" - See taurine at Amazon.com.

Coffee Cuts Stroke Risk in Women - WebMD, 2/16/09 - "women who drank four or more cups of coffee a day had a 20% reduced risk of stroke compared to women who had less than one cup per month. Drinking two to three cups per day reduced risk by 19%. Drinking a cup five to seven times a week reduced risk by 12%"

Chewing Chitosan-Loaded Gum Reduces Phosphate Levels in ESRD Patients - Medscape, 2/16/09 - "Chewing chitosan-loaded gum twice daily can significantly decrease salivary phosphate and serum phosphate levels in hemodialysis patients and may help improve treatment for hyperphosphatemia ... At week 1, the patients’ salivary phosphate levels had decreased from 73.21 to 52.02 mg/dL (P < .01), and serum levels decreased from 7.60 to 5.38 mg/dL (P < .00001). After 2 weeks, salivary phosphate levels were reduced to 33.19 mg/dL (P < .00001) and serum levels decreased to 5.25 mg/dL" - See chitosan products at iHerb.

Why some soldiers are cool under fire - MSNBC, 2/16/09 - "Blood samples taken from soldiers in the training programs showed those who fared best under extreme stress had lower levels of the stress hormone cortisol and higher levels of neuropeptide y, a chemical that dampens the body's stress response"

Healthy People With High Urinary Protein Levels Have Elevated Kidney Disease Risk - Science Daily, 2/12/09 - "individuals with high urinary protein levels are at high risk for losing their kidney function and needing dialysis or a kidney transplant. The higher the level of proteins in the urine, the higher the risk of needing dialysis or a kidney transplant and the more rapid the rate of kidney function decline"

Tomatoes for Endometriosis? - Dr. Weil, 2/13/09 - "A study from Wayne State University in Detroit suggests that lycopene, a powerful antioxidant and the carotenoid pigment that makes tomatoes bright red, can help prevent the scarring that occurs with endometriosis. In a laboratory study, researchers found that it reduced the formation of a protein that causes scar tissue and adhesions to develop by 80 to 90 percent" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.

Cranberry extracts may prevent colon cancer: Lab study - Nutra USA, 2/13/09 - "These findings are important because they demonstrate that the F-κB signalling pathway provides a potential mechanistic link between inflammation and cancer and that the anti-inflammatory properties of crude cranberry extract or quercetin can be used to modulate this pathway" - See cranberry extract at Amazon.com.

Omega-3 Fatty Acids Prevent Medical Complications Of Obesity, Study Suggests - Science Daily, 2/12/09 - "Our study shows for the first time that lipids called protectins and resolvins derived from omega-3 fatty acids can actually reduce the instance of liver complications, such as hepatic steatosis and insulin resistance, in obese people" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Fructose-sweetened Drinks Increase Nonfasting Triglycerides In Obese Adults - Science Daily, 2/12/09 - "Obese people who drink fructose-sweetened beverages with their meals have an increased rise of triglycerides following the meal ... Increased triglycerides after a meal are known predictors of cardiovascular disease"

People Who Exercise Lower Their Risk Of Colon Cancer - Science Daily, 2/12/09 - "people who exercised the most were 24 percent less likely to develop the disease than those who exercised the least"

Vitamin K2, but not K1, effective for heart health benefits: Study - Nutra USA, 2/12/09 - "This study confirms our findings in the Rotterdam study, showing that increased vitamin K2 intake strongly reduces the risk of coronary heart disease" - [Abstract] - See vitamin K at Amazon.com.

Can A Dietary Supplement Stave Off Hearing Loss? - Science Daily, 2/12/09 - "temporary noise-induced hearing loss – the hearing loss you might feel immediately after attending a loud concert but that goes away in a day or two – can be prevented in guinea pigs by a combination of the antioxidants beta-carotene, vitamin C, and vitamin E and the mineral magnesium, when administered before exposure to a loud sound ... In a second study conducted with colleagues at Washington University, the researchers demonstrated that permanent noise-induced hearing loss can also be prevented in mice through the combination of the same nutrients administered before exposure to a loud noise"

Arginine Discovery Could Help Fight Human Obesity - Science Daily, 2/12/09 - "arginine, an amino acid, reduces fat mass in diet-induced obese rats and could help fight human obesity ... dietary arginine supplementation shifts nutrient partitioning to promote skeletal-muscle gain ... The findings were published recently in the Journal of Nutrition ... arginine supplementation for a 12-week period decreased the body fat gains of low-fat and high-fat fed rats by 65 percent and 63 percent, respectively. The long-term arginine treatment did not have any adverse effects on either group ... funded by the American Heart Association" - See L-arginine products at Amazon.com.

Higher Blood Sugar Levels Linked to Lower Brain Function in Diabetics - Doctor's Guide, 2/11/09 - "The ongoing Memory in Diabetes (MIND) study, a sub-study of the Action to Control Cardiovascular Risk in Diabetes Trial (ACCORD), found a statistically significant inverse relationship between A1C levels over a period of 2 to 3 months and subjects' scores on four cognitive tests ... This study adds to the growing evidence that poorer blood glucose control is strongly associated with poorer memory function and that these associations can be detected well before a person develops severe memory loss"

Novel Benefits Of Fatty Acids In Arteries Shown - Science Daily, 2/11/09 - "a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. The beneficial actions of fish oil that block cholesterol buildup in arteries are even found at high fat intakes ... the fatty acids contained in fish oil markedly inhibit the entry of "bad," or LDL, cholesterol into arteries and, as a result, much less cholesterol collects in these vessels ... Dr. Deckelbaum advises those interested in increasing omega-3 intakes do so by either increasing fish intake or by using supplements that contain the "long-chain" fatty acids, EPA and DHA, which are found in cold water fish" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Daily Diet Soda Consumption Linked to Metabolic Syndrome, Type 2 Diabetes - Medscape, 2/11/09 - "Compared with participants who did not drink diet soda, those who drank diet soda at least daily had a 36% greater relative risk for incident MetSyn (HR, 1.36; 95% confidence interval [CI], 1.11 - 1.66) and a 67% greater relative risk for incident type 2 diabetes"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Vitamin C consumption is associated with less progression in carotid intima media thickness in elderly men: A 3-year intervention study - Nutr Metab Cardiovasc Dis. 2009 Jan;19(1):8-14 - "Vitamin C containing foods may protect against the progression of carotid atherosclerosis in elderly men" - See vitamin C products at Amazon.com.

Thiazolidinediones: effects on the development and progression of type 2 diabetes and associated vascular complications - Diabetes Metab Res Rev. 2009 Feb 13;25(2):112-126 - "In 2008, an update of an American Diabetes Association-European Association for the Study of Diabetes consensus statement on initiation and adjustment of therapy in patients with type 2 diabetes advised clinicians against using rosiglitazone. Skeletal fractures have recently emerged as a side effect of both TZDs. Available data suggest that cardiovascular benefits observed with pioglitazone might not be a class effect of TZDs" - Note:  I'm still taking pioglitazone because I feel by keeping blood sugar low you slow aging.  Some docs say I'm crazy but I think it's the other way around.  See pioglitazone at OffshoreRx1.com.  Also see my insulin and aging page.

Vitamin B(12) may be more effective than nortriptyline in improving painful diabetic neuropathy - Int J Food Sci Nutr. 2009 Feb 12:1-6 - "In conclusion, vitamin B(12) is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy" - See vitamin B12 at Amazon.com.

An oily fish diet increases insulin sensitivity compared to a red meat diet in young iron-deficient women - Br J Nutr. 2009 Feb 12:1-8 - "Insulin levels significantly decreased and insulin sensitivity significantly increased with the oily fish diet. HDL-cholesterol significantly increased with the oily fish diet" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Sweetened beverage consumption and risk of coronary heart disease in women - Am J Clin Nutr. 2009 Feb 11 - "sugar-sweetened beverages (SSBs) ... After standard and dietary risk factors were adjusted for, the RRs (and 95% CIs) of CHD according to categories of cumulative average of SSB consumption (<1/mo, 1-4/mo, 2-6/wk, 1/d, and >/=2 servings/d) were 1.0, 0.96 (0.87, 1.06), 1.04 (0.95, 1.14), 1.23 (1.06, 1.43), and 1.35 (1.07, 1.69)"

Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis - Am J Clin Nutr. 2009 Feb 11 - "Our analysis of studies on soy intake yielded a combined RR/OR of 0.74"

A high menaquinone reduces the incidence of coronary heart disease in women - Nutr Metab Cardiovasc Dis. 2009 Jan 27 - "A high intake of menoquinones, especially MK-7, MK-8 and MK-9, could protect against CHD" - See vitamin K at Amazon.com.

Prevention of insulin resistance by n-3 polyunsaturated fatty acids - Curr Opin Clin Nutr Metab Care. 2009 Mar;12(2):138-46 - "n-3 PUFA supplementation has clinical significance in the prevention and reversal of insulin resistance" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Neat Tech Stuff:

• Schlage BE365VPLY505 Plymouth Deadbolt Keypad, Bright Brass - I bought three of these and for $20 had two rekeyed to match the third. Reviewers are giving them an average of 5 stars which you rarely see. You never have to worry about locking yourself out plus you can program a temporary code so authorized people can get in or have a code that you can always call someone and give it to them to get into your house for an emergency then delete that code when you get home. They come in several different finishes.
• Print Directory Listing in Vista - An important feature that was left out of Vista.  It took me a while to find a way to do it.  It looks complicated but it's not.  The second option is probably better because you can import it into Excel.  After it's installed you just right click the folder and select "Print File Directory" or "View File Directory".  Click her for XP with Gizmo or click here.

Supplement Focus (L-arginine):

L-arginine News & Research:

• Arginine - The Natural Pharmacist
• The Effects of L-Arginine and Yohimbine on Sexual Arousal in Postmenopausal Women with FSAD - University of Texas at Austin Dept. of Psychiatry
• Arginine Discovery Could Help Fight Human Obesity - Science Daily, 2/12/09 - "arginine, an amino acid, reduces fat mass in diet-induced obese rats and could help fight human obesity ... dietary arginine supplementation shifts nutrient partitioning to promote skeletal-muscle gain ... The findings were published recently in the Journal of Nutrition ... arginine supplementation for a 12-week period decreased the body fat gains of low-fat and high-fat fed rats by 65 percent and 63 percent, respectively. The long-term arginine treatment did not have any adverse effects on either group ... funded by the American Heart Association"
• Pine bark extract boost for blood flow and heart health - Nutra USA, 10/18/07 - "Acetylcholine stimulates the cells of arteries to produce NO from L-arginine faster ... In turn, the NO causes the muscle surrounding arteries to relax, which results in an increase of blood vessel diameters. When subjects had taken Pycnogenol the relaxation of arteries was increased by 42 per cent as compared to the group taking placebo tablets" - See Pycnogenol at Amazon.com and citicholine at Amazon.com.
• Statins' Effect on Endothelial Function Enhanced by L-arginine in Some Patients - Doctor's Guide, 6/11/07 - "endothelium-dependent dilation (EDD) ... simvastatin had no appreciable effect on EDD (6.2+/-1.2% vs. 6.1+/-0.9%) in subjects with elevated ADMA. However, the addition of L-arginine to simvastatin significantly improved EDD (9.8+/-1.5% vs. 5.3+/-0.8%; P <.01). There were also significant improvements in EDD in response to L-arginine alone"
• Restoring Sexual Potency? - Dr. Weil, 5/4/06 - "Arginine ... Ginkgo biloba ... Ashwaganda"
• Don't Take L-Arginine for Heart Attack - WebMD, 1/3/06 - "All six deaths were among the 78 heart attack patients who added L-arginine to their normal medical treatment regimen. There were no deaths among the 75 heart attack patients who did not receive L-arginine"
• The high five for hypertension - Functional Foods & Nutraceuticals, 12/04 - "Co-enzyme Q10 ... Omega-3 fatty acids ... Garlic ... L-arginine ... Calcium"
• OTC Cream Improves Blood Flow in Feet - WebMD, 1/8/04 - "arginine does increase blood flow, but it is not yet clear if this translates into fewer foot ulcers or better healing of ulcers"
• Nitric Oxide Now -- Ask Me How -  WashingtonPost.com, 10/6/03 - "In the arteries, the innermost layer of cells releases nitric oxide to signal smooth muscle cells to dilate (increase the diameter of) the arteries. This allows blood to flow more freely, particularly during exercise ... By the 1990s, many scientists saw nitric oxide as the next great weapon for treating heart disease, impotence and even bacterial infections ... Niteworks has L-arginine and also L-citrulline, which recycles spent L-arginine by resupplying it with atoms it lost producing nitric oxide ... "Ninety dollars a month? That's obscene," Murad said. "You can probably get [vitamin] C and E for pennies a day. You can probably get arginine for about a dollar a day"" - See L-citrulline at Amazon.com.
• Arginine Supplements May Help Treat Pulmonary Hypertension in Sickle Cell - Medscape, 6/30/03
• Protecting Blood Vessels From Stress - WebMD, 1/15/03 - "vitamins can improve blood flow and prevent the long-term development of atherosclerosis -- or hardening of the arteries -- when given in combination with an amino acid known as L-arginine ... antioxidants might work together with L-arginine to prevent inflammation in the branch areas of blood vessels ... although antioxidants may not reverse or repair pre-existing damage within blood vessels, they may slow the long-term progression of atherosclerosis"
• L-Arginine Minimises Stroke Damage in Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes - Doctor's Guide, 10/16/02
• Natural Remedy for Erectile Dysfunction - New Hope Natural Media, 9/5/02 - "received three separate treatments for two weeks each, in random order: (1) 3.25 grams of arginine plus 6 mg of yohimbine, (2) yohimbine alone and (3) placebo ... Combination treatment was considered successful by 40% of the participants, compared with 28.9% with yohimbine alone and 17.8% with placebo ... Arginine is available in health food stores without a prescription, but yohimbine can be obtained only with a doctor's prescription. Although the herb yohimbe is sold in health food stores, it contains much less yohimbine than the amount used in the new study" - See iHerb and Vitacost arginine products.
• Yohimbine Plus L-Arginine Potential Therapy For Mild To Moderate Erectile Dysfunction - Doctor's Guide, 7/31/02 - "randomly assigned 45 men with erectile dysfunction to treatment with 6 mg of L-arginine glutamate combined with 6 mg of yohimbine hydrochloride, to 6 mg of yohimbine hydrochloride alone, or to placebo ... They took the drugs orally one to two hours before intended sexual intercourse ... Changes in this score [Index of Erectile Function (IIEF)] were significantly greater among patients taking yohimbine plus L-arginine compared to those taking placebo" - Note: That "6 mg of L-arginine glutamate" has to be a misprint.  It probably should have been 6 grams as in a U. of Texas study on postmenopausal women.
• Arginine and Fish Oil May Help Cancer Patients Undergoing Chemotherapy - Life Extension Magazine, 7/02
• L-Arginine Application Speeds Healing of Anal Fissure - Doctor's Guide, 6/10/02
• Concepts and Controversies in Nutrition, Immune-Enhancing Formulas - Medscape, 3/21/02 - "Immune-enhancing formulas (IEFs), also known as immune-modulating formulas, include arginine, glutamine, nucleic acids, and omega-3 fatty acids"
• The Wizard is Oz - Life Extension Magazine, 11/01 - "Best-selling author and nutritional guru to the rich and famous, Oz Garcia is singing the praises of the Life Extension Foundation and its products in his newest book, The Healthy High Tech Body, published in September 2001 ... Supplements at the top of Garcia's list of recommendations ... DHA ... NADH ... Alpah Lipoic Acid ... Acetyl-L-Carnitine ... An expanded list of his recommendations includes lycopene, gamma tocopherol, vinpocetine, SAMe, folic acid, carnosine, glutathione, DMAE, Huperzine A, probiotics, MSM, secretagogues, arginine pyroglutamate, IP-6, bioflavonoid formulas and grape skin/seed extracts"
• Nutritional Supplement Boosts Immune Function In Surgery Patients - Intelihealth, 9/13/01 - "A new study published in the journal Lancet suggests that people who are at high risk of infection after heart surgery may benefit from taking a nutritional supplement containing L-arginine and omega-3 fatty acids"
• Quinopril and L-Arginine Improves Endothelial Function In Hypertensive Patients - Doctor's Guide, 6/21/01
• Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction, Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 - "ArginMax -- a dietary cocktail consisting of ginseng, ginkgo, B vitamins, calcium, folic acid, and other vitamins and minerals -- is being heralded as one component of a lifestyle that improves sexual performance and helps prevent problems associated with intimacy"
• Want a love potion? What to know before you try - CNN, 6/15/00 - "a study of 21 men with "mild to moderate" impotence taking a supplement called ArginMax (3,000 milligrams per day) found big improvements in erection and sexual satisfaction."
• Two Amino Acids Boost Immune System During Illness - WebMD, 8/1/00
• Exercise-Supplement Combo May Help a Failing Heart - WebMD, 3/1/00
• Growth Hormone Enhancer - Nutrition Science News, 1/00
• Immune-Enhancing Therapy Shortens Hospital Stays By Three Days - Doctor's Guide, 12/23/99 - "The trials, conducted at medical centers in the U.S. and Europe, compared patients receiving standard enteral nutrition with patients who received commercially available immune-enhancing therapies containing arginine and glutamine (naturally occurring amino acids), nucleotides (found in yeast), and omega-3 fatty acids (found in fish oil) ... Our study shows that immunonutrition can make a significant contribution to reducing the number of infections and length of hospital stay in critically ill patients"
• Women and Sex Drive -  Life Enhancement Magazine, 12/99 - "Because the amino acid arginine is the precursor to nitric oxide, its ingestion and concomitant elevation in the serum accomplish much the same goal as Viagra, as several studies have borne out"
• Arginine for Muscles, Memory, Sex and More - Life Enhancement Magazine, 12/99 - "Arginine is the primary source of the nitrogen that results in production of the important biomolecule nitric oxide (NO) ... NO helps defend the body against invading bacteria2 and parasites. In the brain, where it is formed in nerve cells, it diffuses in all directions, activating all cells in the vicinity, thus modulating many functions, including behavior and gastrointestinal transit flow. The release of NO is absolutely essential for motor learning in the cerebellum (coordination), and it also appears to be necessary for long-term potentiation in the brain, which is the mechanism involved in long-term memory. NO is now also thought to be important in our olfactory (smelling) sensations and our capacity to identify different scents ... Free arginine has been shown to help prevent a destructive process known as cross-linking, which is associated with accelerated aging. Excessive cross-linking reactions inevitably damage the kidneys, necessitating dialysis in advanced age"
• Study finds new therapy for impotence - CNN, 10/27/99 - "Nitric oxide is the messenger, if you will, the signaling molecule, and without that signal you can't get that signal from the brain to the penis for the erectile process ... An amino acid call L-argenine produces nitric oxide in the body"
• Be All That You Can Be - Life Enhancement Magazine, 7/99 - "the erections were harder and longer-lasting and so forth when they were using L-arginine. The two studies I have in mind used 2,800 mg and 2,500 mg of arginine, respectively"
• Viagra anniversary sees herbal competitors by the dozens - CNN, 3/26/99 - "Since the main problem in impotence is actually a problem with circulation of the blood vessels in the penis, l-arginine holds great promise for men with physical impotence"
• Prosexual Enhancement - Life Enhancement Magazine, 3/97 - "According to numerous anecdotal reports from highly satisfied arginine users since the early 1980s, dietary L-arginine can give men erections that are bigger, harder, more frequent, and longer lasting. Some men also report that L-arginine gives them greater endurance. In women, L-arginine has been reported to increase the intensity of sensation during sex. One highly athletic 30-something woman tells about the time she told her doctor about her L-arginine use. "My doctor almost fell off his chair when I told him how many times a night I do it - six-times," she said. "He's definitely taking arginine now, too.""

L-arginine Abstracts:

• Dietary L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats - J Nutr. 2008 Dec 23 - "l-arginine-HCl ... Despite similar energy intake, absolute weights of white fat pads increased by 98% in control rats over a 12-wk period but only by 35% in arginine-supplemented rats. The arginine treatment reduced the relative weights of white fat pads by 30% and enhanced those of soleus muscle by 13%, extensor digitorum longus muscle by 11%, and brown fat by 34% compared with control rats ... arginine treatment resulted in lower serum concentrations of leptin, glucose, triglycerides, urea, glutamine, and branched-chain amino acids, higher serum concentrations of nitric-oxide metabolites, and improvement in glucose tolerance. Thus, dietary arginine supplementation shifts nutrient partitioning to promote muscle over fat gain and may provide a useful treatment for improving the metabolic profile and reducing body white fat in diet-induced obese rats" - See arginine products at Amazon.com.
• Addition of 2.5g l-arginine in a fatty meal prevents the lipemia-induced endothelial dysfunction in healthy volunteers - Atherosclerosis. 2008 Nov 6 - "2.5g l-arginine, but not phenyalanine or leucine, is able to prevent the lipemic dysfunction of the endothelium"
• Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase (-/-) mice and improved by combined administration of L-arginine and antioxidants - Nephrology (Carlton). 2008 Jun;13(3):218-27 - "A combination of L-arginine and antioxidant treatment ameliorated renal damage"
• Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus - Diabetes Care. 2008 Feb 11 - "The NAC+ARG administration seems to be a potential well-tolerated antiatherogenic therapy since it improves the endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of the oxidative stress and increase of NO production. Our study's results give prominence to its potential use in the primary and secondary cardiovascular prevention in these patients"
• Pharmacokinetics of arginine and related amino acids - J Nutr. 2007 Jun;137(6):1646S-9S
• Biomarkers of arginine and lysine excess - J Nutr. 2007 Jun;137(6):1662S-8S - "Arginine supplementation is used in several disease states. In arginine-deficient states, supplementation is a logical choice of therapy. However, the definition of an arginine-deficient state is complex. For example, plasma arginine levels could be within normal range but intracellular arginine levels could be reduced because of membrane transport problems. Lysine competes with arginine for transport into the cell. In these situations, arginine supplementation of higher than required levels is proposed. Arginine has several important functions in metabolism as it is a precursor of metabolically active components such as nitric oxide (NO), ornithine, creatine, and polyamines"
• Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans - Biomed Res. 2007 Apr;28(2):85-90 - "the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects"
• l-Arginine, the substrate for NO synthesis: An alternative treatment for premature atherosclerosis? - Int J Cardiol. 2006 Jul 20 - "l-arginine administration may be useful in patients with premature atherosclerosis"
• Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial - Clin Nutr. 2005 Nov 14;24(6):979-987 - "In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer healing"
• Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina - Heart. 2005 Oct;91(10):1319-23 - "L-arginine dependent coronary segment vasodilatation was augmented by the antioxidant vitamin C in patients with coronary artery disease. Thus, vitamin C may have beneficial effects on nitric oxide bioavailability induced by L-arginine"