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Anti-aging Research > L-Glutamine
News & Research:
L-glutamine form could boost uptake by 224%: Study - Nutra USA, 5/9/12
Glutamine Supplements Show Promise In Treating Stomach Ulcers - Science
Daily, 5/15/09 - "the amino acid glutamine, found in
many foods as well as in dietary supplements, may prove beneficial in
offsetting gastric damage caused by H. pylori infection ... at
six-weeks-post infection, the animals exhibited increased expression of
three cytokines – interleukin 4, interleukin 10 and transforming growth
factor-alpha mRNA. "These all play an important role in the stomach's
ability to protect against damaging effects resulting from other responses
to H. pylori infection ... Of even greater significance, by week 20, the
study results showed that, among the H. pylori-infected animals, the mice
that were fed the L-glutamine diet exhibited lower levels of inflammation
than did the mice that received the standard control diet"
Supplementation May Protect Very Low-Birth-Weight Infants - Medscape,
Glutamine Independently Reduces Hospital Stay - Doctor's Guide, 10/25/05
- "The nutrient glutamine, which is
often administered as part of nutritional supplementation, on its own can
reduce the length of hospital stay and maintains lean body mass after
elective surgery" - See
- Glutamine Improves Outcomes in Burn Patients -
- Muscular Enhancement Supplements: Creatine, HMB, and Glutamine review
- ConsumerLab.com, 9/25/03
Ask Dr. J - Dr. Janson, 4/02 -
"L-glutamine is an amino acid that helps heal the lining of the entire
digestive tract, so it is useful for inflammatory bowel disease as well as esophagitis"
Glutamine: The Essential "Non- Essential" Amino Acid - Life Extension
- Concepts and Controversies in Nutrition, Immune-Enhancing Formulas
- Medscape, 3/21/02 -
"Immune-enhancing formulas (IEFs),
also known as immune-modulating formulas, include
arginine, glutamine, nucleic acids, and
omega-3 fatty acids"
- Glutamine Helps Treat AIDS - Nutrition Science
- 'Building Blocks of Life' Might Help Pump You Up -
WebMD, 7/28/00 -
"during exercise, one particular amino acid -- glutamine -- is depleted in
the blood supply. Glutamine is involved in keeping the immune system healthy
to ward off illness"
Growth Hormone Enhancer - Nutrition Science News, 1/00
Immune-Enhancing Therapy Shortens Hospital Stays By Three Days -
Doctor's Guide, 12/23/99 - "Our
study shows that immunonutrition can make a significant contribution to
reducing the number of infections and length of hospital stay in critically
Essential Nutrients for Endurance Athletes - Nutrition Science News,
5/99 - "In the seven days following
the exercise, 81 percent of the glutamine-supplemented group were
infection-free compared to 49 percent in the placebo group."
modifies immune responses of mice infected with porcine circovirus type 2 -
Br J Nutr. 2013 Jan 28:1-8 - "Taken together, the
present results suggest that dietary l-glutamine supplementation enhances immune
function in PCV2-infected mice"
the ICU: Who needs supply? - Clin Nutr. 2012 Dec 14 -
"Many ICU patients are glutamine depleted and have low
glutamine plasma concentrations. Beneficial effects by glutamine supply could be
proven in these patients. In some medical conditions, especially those with
acute right heart failure, elevated glutamine plasma concentrations are present
and glutamine supply may be disastrous and a toxic burden. It will be prudent to
reassess the use of glutamine in ICU especially in conditions with unresolved
shock or right heart failure"
wound closure in trauma patients with disorders in wound healing is shortened by
supplements containing antioxidant micronutrients and glutamine: A PRCT -
Clin Nutr. 2012 Jan 25 - "20 trauma patients with
disorders in wound healing were orally supplemented with antioxidant
micronutrients (ascorbic acid, α-tocopherol, β-carotene, zinc, selenium) and
glutamine (verum) or they received isoenergetic amounts of maltodextrine
(placebo) for 14 days ... Wound closure occurred more rapidly in the verum than
in the placebo group (35 +/- 22 vs. 70 +/- 35 d; P = 0.01)"
critical illness: the time has come, the time is now - Crit Care Clin. 2010
Jul;26(3):515-25 - "Glutamine (GLN) has been shown to be a key pharmaconutrient
in the body's response to stress and injury. It exerts its protective effects
via multiple mechanisms, including direct protection of cells and tissue from
injury, attenuation inflammation, and preservation of metabolic function. Data
support GLN as an ideal pharmacologic intervention to prevent or treat multiple
organ dysfunction syndrome after sepsis or other injuries in the intensive care
unit population. A large and growing body of clinical data shows that in
well-defined critically ill patient groups GLN can be a life-saving
The role of parenteral
glutamine supplement for surgical patient perioperatively: result of a
single center, prospective and controlled study - Langenbecks Arch Surg.
2008 Aug 20 - "In terms of morbidity, there was no
difference between the two groups, but two patients in the control group had
wound infection; none was noted in the Gln group (p = 1.0). No surgical
mortality was noted in this study. CONCLUSIONS: Perioperative parenteral
nutrition supplemented with Gln is beneficial for patients undergoing GI
surgery. Gln supplementation significantly attenuated postoperative
inflammation and ameliorated postoperative immunodepression as well as
nutritional depression in GI surgery"
Glutamine: role in critical illness and ongoing clinical trials - Curr
Opin Gastroenterol. 2008 Mar;24(2):190-7 - "Severe
glutamine deficiencies occur rapidly in critical illness. The magnitude of
glutamine deficiency is correlated with ICU mortality. Further, metaanalysis
reveals glutamine reduces morbidity and mortality in critical illness"
Glutamine supplementation increases postprandial energy expenditure and fat
oxidation in humans - JPEN J Parenter Enteral Nutr. 2006
Glutamine, exercise and immune function. Links and possible mechanisms -
Sports Med. 1998 Sep;26(3):177-91