Recent Longevity News for the seven days ending 8/5/09.  You should consult your doctor if you are taking any medications.

Low vitamin D levels linked to metabolic syndrome - Nutra USA, 8/4/09 - "According to findings published in the Journal of Clinical Lipidology, the lowest levels of the sunshine vitamin were associated with a 31 per cent prevalence of metabolic syndrome, compared to only 10 per cent for people wit the highest average levels" - See vitamin D at Amazon.com.

Homeland Secretary Napolitano predicts severe flu epidemic for fall - USATODAY.com, 8/4/09 - "U.S. Secretary of Homeland Security Janet Napolitano asserted Tuesday that pandemic flu is likely to flare up soon after schools open in the fall, well before any vaccine is available ... The flu strain causing the pandemic, a new strain of H1N1 flu that is also known as swine flu, is especially dangerous because it is genetically different from virtually every other known flu virus. As a result, most people are defenseless against it ... She said it's more likely that the pandemic would mirror 1957, when flu killed about 70,000 people in the USA and more than one million people worldwide ... That's about twice the death toll of seasonal flu, which annually kills about 36,000 people and results in 200,000 hospitalization" - Click here for my Purell plug.  See the video commercial at the bottom of the page.  When I was younger in the navy I got a strain of flu my body wasn't used to in Australia and I thought that was going to kill me.

High Cholesterol Linked to Alzheimer's - WebMD, 8/4/09 - "Adults with even moderately elevated cholesterol in their early to mid-40s appear to have an increased risk for Alzheimer's disease and related dementias decades later ... Total cholesterol in the high range at study entry was associated with a 66% increase in Alzheimer's risk, while having borderline high cholesterol raised the risk for vascular dementia by 52% ... total cholesterol of 240 or higher is considered high, and a cholesterol of 200 to 239 is considered borderline high" - Maybe that's why most studies on statins show that statins reduce the odds of having Alzheimer's. - Ben

'Brain Exercises' May Delay Memory Decline In Dementia - Science Daily, 8/4/09 - "People who engage in activities that exercise the brain, such as reading, writing, and playing card games, may delay the rapid memory decline that occurs if they later develop dementia"

Sex Hormones Associated With Broken Bones In Older Men - Science Daily, 8/3/09 - "Low levels of estradiol or high levels of sex hormone binding globulin (SHBG) are associated with an increased risk of osteoporotic fracture in older men"

FDA Approves Livalo, a New Statin - WebMD, 8/3/09 - "The FDA has approved a Livalo, a new cholesterol-lowering statin drug"

Daily Omega-3s Recommended for Heart - WebMD, 8/3/09 - "omega-3 fatty acids' strongest protective effect appears to be in people with established heart disease after a heart attack. In these people, a daily dose of DHA and EPA is associated with a 30% reduction in the risk of heart-related death ... But researchers say healthy people can also benefit from including omega-3s in their diet. Research shows a diet rich in omega-3s can also reduce the risk of hardening of the arteries (atherosclerosis), irregular heartbeat (arrhythmia), heart attack, sudden cardiac death, and heart failure" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

7 in 10 U.S. Kids Have Low Vitamin D - WebMD, 8/3/09 - "Seven out of 10 U.S. children have too-low vitamin D levels, putting them at risk of heart disease, rickets, and weak bones ... Most people need regular vitamin D supplements ... Kids who have low vitamin D levels are at serious risk of heart disease in adulthood ... even after controlling for all kinds of factors that affect heart disease risk -- obesity, exercise levels, race/ethnicity, age, gender, and socioeconomic status -- low vitamin D put kids at risk of heart disease as adults" - See vitamin D at Amazon.com.

Anthocyanins linked to improved cholesterol levels - Nutra USA, 8/3/09 - "assigned 120 people aged between 40 and 65 with abnormal blood lipid levels (dyslipidemia) to receive either a daily dose of 320 mg of anthocyanins or placebo for 12 weeks ... After 12 weeks of supplementation, HDL cholesterol levels increased by almost 14 per cent in the anthocyanin group, compared to a rise of only 2.8 per cent in the placebo group. Furthermore, LDL cholesterol levels decreased by 13.6 per cent in the anthocyanin group, compared to an increase of 0.6 per cent in the placebo group ... The removal of cholesterol from cells, the so-called cellular cholesterol efflux, was found to increase by 20 per cent in the anthocyanin group, compared to a 0.2 per cent in the placebo group" - [Abstract] - See blueberry extract at Amazon.com and bilberry at Amazon.com.

FDA Approves Saxagliptin for Type 2 Diabetes - Doctor's Guide, 7/31/09 - "Although saxagliptin was not associated with an increased risk for cardiovascular events in patients who were mainly at low risk for these events, the FDA is requiring a post-market study that will specifically evaluate cardiovascular safety in a higher risk population"

Green tea may protect against blood cell cancer - Nutra USA, 7/31/09 - "Drinking five or more cups of green tea per day may reduce the risk of blood- and lymph-based cancers by about 50 per cent ... Compared to people who drank only one cup per day, five cups of green tea a day were associated with a 42 per cent reduction in hematologic malignancies, and a 48 per cent risk reduction in lymphoid neoplasms" - [Abstract] - See green tea extract at Amazon.com.

Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary Liver Cancer In Rats - Science Daily, 7/30/09 - "A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats" - [Abstract] - See SAM-e at Amazon.com.

Scientists Uncork Potential Secret Of Red Wine's Health Benefits - Science Daily, 7/30/09 - "researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation. The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective" - See resveratrol products at Amazon.com.

Got Zinc? New Zinc Research Suggests Novel Therapeutic Targets - Science Daily, 7/30/09 - "zinc not only supports healthy immune function, but increases activation of the cells (T cells) responsible for destroying viruses and bacteria ... It has been shown that zinc supplementation significantly reduces the duration and severity of childhood diarrhea, lower respiratory infections, and incidence of malaria in zinc-deficient children ... Age-related declines in immune function have also been related to zinc deficiency in the elderly ... T cells taken from the zinc-supplemented group had higher activation than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T cells called "ZIP8," which transports stored zinc into the cell cytoplasm where it then alters the expression of a T cell protein in a way needed to fight infections" - See Jarrow Zinc Balance at Amazon.com (too much zinc can cause a copper deficiency.

Probiotics may reduce cold and 'flu symptoms for children - Nutra USA, 7/30/09 - "A daily supplement of Lactobacillus and Bifidobacterium strains may reduce the incidence of cold and 'flu-like symptoms in children by 50 per cent ... A combination of the two strains was linked to reductions in fever incidence by 73 per cent, a reduction in the occurrence of runny noses by 59 per cent, and drop in the incidence of coughing by 62 per cent" - [Abstract] - See probiotics at Amazon.com.

Low Prevalence Of HPV Infection May Be Tied To Poor Prognosis For Blacks With Head And Neck Cancer - Science Daily, 7/29/09 - "Only 4 percent of black patients with squamous cell carcinoma in the study were HPV-positive, compared with 34 percent of white patients. The median overall survival was more than three-fold higher for whites (70.6 months) than for blacks (20.9 months) who were treated with chemotherapy and radiation. Dr. Cullen says the survival rate at five years for HPV-positive patients was about 85 percent, compared to 35 percent for HPV-negative patients. Survival was similar for HPV-negative patients, regardless of race. The study's findings confirm that HPV infection relates specifically to a type of head and neck cancer -- cancer of the oropharynx, which include the tonsils, soft palate and base of the tongue ... Overall, about 25 percent of head and neck cancers are tied to HPV infection" - Note:  I'm cancer free after 4.5 years after cancer of the tonsil that spread to a lymph node in the neck (click here).  The lymph node tumor was the size of a golf ball by the time I noticed it.  I refused radiation and the chemo at the time did not increase survival.  I assume it was HPV because of my survival and the fact that I've never smoked.

Swine Flu Could Eventually Affect 40% of Americans: CDC - US News and World Report, 7/24/09 - "The H1N1 swine flu could end up affecting as many as 40 percent of Americans ... The projection from the U.S. Centers for Disease Control and Prevention is based on the influenza pandemic in 1957, when almost 70,000 people in the United States died from the flu"

• Swine Flu: To Panic Or Not -- That Is The Question - Science Daily, 4/30/09 - "Wash your hands. “Hand hygiene can not be stressed enough""
• CDC: 40% of American's will be affected by Swine Flu - 2:32 minute news video, 8/3/09 - It claims it can even be spread via paper or the mail.
• Click here and see my video commercial at the bottom of that page for a Purell automatic dispenser.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity - Diabet Med. 2009 May;26(5):526-31 - "GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk" - See grape seed extract at Amazon.com.

Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects - Am J Clin Nutr. 2009 Jul 29 - "Anthocyanin consumption increased HDL-cholesterol concentrations (13.7% and 2.8% in the anthocyanin and placebo groups, respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6% and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001). The cellular cholesterol efflux to serum increased more in the anthocyanin group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001). Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3% in the anthocyanin group and -3.5% and 1.1% in the placebo group, respectively; P < 0.001)" - See blueberry extract at Amazon.com and bilberry at Amazon.com.

Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs - Am J Clin Nutr. 2009 Jul 29 - "Our data show that vitamin C deficiency in early postnatal life results in impaired neuronal development and a functional decrease in spatial memory in guinea pigs. We speculate that this unrecognized effect of vitamin C deficiency may have clinical implications for high-risk individuals, such as in children born from vitamin C-deficient mothers"

Green Tea Consumption and Hematologic Malignancies in Japan: The Ohsaki Study - Am J Epidemiol. 2009 Jul 29 - "Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). The corresponding risk estimate was 0.52 (95% confidence interval: 0.31, 0.87) for lymphoid neoplasms and 0.76 (95% confidence interval: 0.32, 1.78) for myeloid neoplasms" - See green tea extract at Amazon.com.

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model - Hepatology. 2009 Apr 6 - "SAMe is effective in preventing HCC establishment but ineffective in treating established HCC because of induction of hepatic methyltransferases, which prevents SAMe level to reach high enough to kill liver cancer cells. SAMe's chemopreventive effect may be related to its proapoptotic action and its ability to inhibit angiogenes" - See SAM-e at Amazon.com.

Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children - PEDIATRICS Vol. 124 No. 2 August 2009, pp. e172-e179 - "Relative to the placebo group, single and combination probiotics reduced fever incidence by 53.0% (P = .0085) and 72.7% (P = .0009), coughing incidence by 41.4% (P = .027) and 62.1% (P = .005), and rhinorrhea incidence by 28.2% (P = .68) and 58.8% (P = .03), respectively. Fever, coughing, and rhinorrhea duration was decreased significantly, relative to placebo, by 32%" - See probiotics at Amazon.com. Note:  This abstract wasn't in Medline yet.

Cognitive Deficit in Amyloid-{beta}-Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-{gamma} Activation - Hypertension. 2009 Jul 27 - "Taken together, our findings suggest that even a low dose of telmisartan had a preventive effect on cognitive decline in an Alzheimer disease mouse model, partly because of PPAR-gamma activation" - Click here for reasons telmisartan might be a good choice for a first line treatment for hypertension.

Metabolic syndrome and serum carotenoids: findings of a cross-sectional study in Queensland, Australia - Br J Nutr. 2009 Jul 27:1-10 - "Mean serum alpha-, beta-carotenes and the sum of the five carotenoid concentrations were significantly lower (P < 0.05) in persons with the metabolic syndrome ... alpha-, beta- and total carotenoids also decreased significantly (P < 0.05) with increased number of components of the metabolic syndrome ... Low concentrations of serum alpha-, beta-carotenes and the sum of five carotenoids appear to be associated with metabolic syndrome status" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.

Neat Tech Stuff :

• Click here for my automatic Purell dispenser commercial.  It's the video at the bottom of the page.  Maybe I can take Billy Mays place since he passed away about a month ago. Ya think?  I’ll add the video to my resume.

Supplement Focus (Omega-3):

CME:

• Omega-3 Fatty Acids in the Management of Hypertriglyceridemia: New Findings and Formulations - Continuing Medical Education (CME):Princeton Media Associates, exp. 10/29/06 - "To lower TG levels, the dose of omega-3 therapy is ~4 g of EPA + DHA per day"
• Omega-3 Fatty Acids: Recommendations for Therapeutics and Prevention - Medscape, exp. 10/19/06 - "Studies support low DHA as a risk factor for dementia. Low total n-3 fatty acids levels, EPA and DHA associate with greater risk of CVD, dietary intake and/or supplementation is supported as a secondary or tertiary prevention measure. Omega-3 fatty acids also help to prevent type 2 diabetes and the metabolic syndrome, two common precursors to CVD. There is some support for schizophrenia, depressive or aggressive disorders; however, large multi-center clinical trials have yet to be conducted. The anti-inflammatory properties of n-3 fatty acids are helpful in decreasing symptoms of rheumatoid arthritis and may possibly increase remission length in Crohn's patients"
• Omega 3: Implications in human health and disease - PowerPak (CME course), exp. 8/1/03 - "On average, our society consumes around 35% of its caloric intake from fat, mainly as vegetable oil. The omega 6 LA comprises 7% to 9% of our daily caloric intake, while the omega 3 LNA makes up about 0.7% of energy. It is therefore estimated that the dietary ratio of LA to LNA ranges from 10 to 20:1, at which level the metabolism of LNA is strongly suppressed.2,25 Again, this is far more than the recommended ratio of 2.3:1" - See Mega Twin EPA at Vitacost or iHerb.

General Information:

• See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• An Evidence-Based Medicine Approach to the Appropriate Selection of Supplementation with Omega-3 Fatty - PowerPak.com, 6/1/07 - "Fish oils EPA and DHA appear to result in different physiologic effects than their precursor, the plant-derived ALA.12-14 Biosynthesis of EPA or DHA from ALA is limited. Although dietary consumption of ALA alone will prevent EFA deficiency, emerging scientific evidence indicates that for optimum health or body function, the fish oils EPA and DHA should also be ingested regularly, either from dietary or supplement sources. Use of ALA supplementation alone, even with high dose or long-term consumption, does not result in lowered triglyceride concentrations seen with EPA or DHA, nor does it demonstrate similar in vitro susceptibility to oxidation of LDL cholesterol"
• The Heart-Healthy Benifits of Omega-3 Fatty Acids - John Hopkins University School of Medicine, 6/05 - "Fish-oil supplements appear to have much lower levels of toxins than fish. In a study of 5 over the-counter fish-oil preparations, levels of PCBs and organochlorines were below the detectable limit in all of the supplements ... Because consumption of this amount of fish in secondary prevention is difficult for most individuals, dietary supplementation is generally needed and should be recommended. The dose in secondary prevention should be at least 875 mg of EPA + DHA per day. This dose can generally be obtained by taking 2 capsules of concentrated fish oils (at least 50% EPA + DHA) per day. For example, such a preparation would contain 500 mg of EPA + DHA per each 1000-mg fish-oil capsule"
• Omega 3: Implications in Human Health and Disease - PowerPak.com - "It should be noted, however, that flaxseed or flaxseed oil does not contain EPA or DHA. Thus flaxseed and fish oil are not interchangeable sources of omega 3 fatty acids per se" - I believe the same holds true for canola oil - Ben
• Omega 3: Implications in Human Health and Disease -PowerPak.com -"The omega 6 LA comprises 7% to 9% of our daily caloric intake, while the omega 3 LNA makes up about 0.7% of energy. It is therefore estimated that the dietary ratio of LA to LNA ranges from 10 to 20:1, at which level the metabolism of LNA is strongly suppressed. Again, this is far more than the recommended ratio of 2.3:1 ... From an evolutionary perspective, a significant change in the diet has occurred in a very short time. The diet of our ancestors in the Paleolithic period (400,000 to 45,000 years ago) was lower in fat and balanced in omega 6 and omega 3—a ratio of 1:1, or 10- to 20-fold lower than today's standard."
• THE A-Z's of OMEGA-3's - bipolarchild.com, Spring 2001
• Omega-3 Fatty Acids - Pharmaceutical Grade Marine Lipids - Dr. Murray (.pdf)
• Omega-3 Fatty Acids - The Natural Pharmacist
• Heart Health - Fish Oil - natmedonline.com

News & Research:

• Omega-3 may prevent blindness in the elderly: Study - Nutra USA, 7/23/09 - "A diet high in omega-3 fatty acids may prevent the development of age-related macular degeneration (AMD) ... mice fed a high omega-3 fatty acid diet displayed a slower development of lesions in their retina, compared to animals fed a low omega-3 diet. Furthermore, some of the mice in the omega-3 group displayed some reversion of the lesions" - [Abstract] - [Science Daily] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Omega-3 Supplements Provide Mixed Results as Antidepressant - Medscape, 7/8/09 - "There is a large body of epidemiological data to support a link between omega-3 and depression ... For example, 8 of 11 epidemiological studies evaluating the association between depression and fish consumption report a statistically significant inverse association. In other words, less fish means more depression"
• Oily fish may reduce dementia risk: Transcontinental study - Nutra USA, 7/8/09 - "Almost 15,000 people aged 65 or over were surveyed. After adjusting for various confounders and pooling the data from all the sites, the researchers report that they observed a dose-dependent inverse association between dementia and fish consumption" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Rat study: Krill beats fish omega-3s in battling metabolic dysfunctions - Nutra USA, 6/30/09
• Omega-3 deficiency causes 96,000 US deaths per year, say researchers - Nutra USA, 6/26/09 - "this new study validates that Omega-3 EPA/DHA is more than just part of a healthy diet...it's a matter of life and death ... We know that daily doses of Omega-3 EPA/DHA can help with many conditions, such as cardiovascular disease, and we're committed to increasing consumer awareness about the drastic Omega-3 EPA/DHA deficiency in the Western diet"
• Omega-3 Fatty Acids May Protect Against Progression Of Age-related Macular Degeneration - Science Daily, 6/18/09 - "we observed participants with early stages of AMD in the placebo group benefited from higher intake of DHA, but it appears that the high-dose supplements of the antioxidants and/or the minerals somehow interfered with the benefits of DHA against early AMD progression ... The antioxidant supplements did not seem to interfere with the protective effects of DHA and EPA against progression to advanced stages of AMD. Participants who consumed higher amounts of DHA and EPA appeared to have lower risk of progression to both wet and dry forms of advanced AMD" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Omega-3 plus AREDS supplement works for eye health: Study - Nutra USA, 6/16/09 - "Increased intake of DHA was associated with a 27 per cent reduction in the progression to advanced age-related macular degeneration (AMD), while EPA was linked to a 26 per cent reduction" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease? - Science Daily, 6/9/09 - "The prevalence of depression ranged from 23% in participants in the lowest tertile of omega –3 fatty acids (< 3.1% of total blood fatty acids) to 13% in participants in the highest tertile ( >4.3% of total blood fatty acids; p for trend = 0.004). Each unit decrease in EPA + DHA was inversely associated with depressive symptoms as a continuous variable, and these associations persisted after adjustment for age, sex and race. Similarly, each SD decrease in EPA + DHA was associated with significantly greater odds of depression as a dichotomous variable (Patient Health Questionnaire score >10)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Omega-3 may improve blood pressure during weight loss - Nutra USA, 6/2/09 - "Consumption of fatty fish like salmon, or fish oil supplements, may reduce blood pressure during an energy-restricted diet"
• Omega Fatty Acid Balance Can Alter Immunity And Gene Expression - Science Daily, 5/29/09 - "Anthropological evidence suggests that human ancestors maintained a 2:1 w6/w3 ratio for much of history, but in Western countries today the ratio has spiked to as high as 10:1. Since these omega fatty acids can be converted into inflammatory molecules, this dietary change is believed to also disrupt the proper balance of pro- and anti- inflammatory agents, resulting in increased systemic inflammation and a higher incidence of problems including asthma, allergies, diabetes, and arthritis ... many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses"
• Eating Fish, Nuts And Olive Oil May Be Associated With Reduced Risk Of Age-related Blindness - Science Daily, 5/15/09 - "Individuals who consumed higher levels of trans-unsaturated fats—found in baked goods and processed foods—were more likely to have late AMD, whereas those who consumed the most omega-three fatty acids were less likely to have early AMD. "Olive oil intake (100 milliliters or more per week vs. less than 1 milliliter per week) was associated with decreased prevalence of late AMD," the authors write. "No significant associations with AMD were observed for intakes of fish, total fat, butter or margarine.""
• Mediterranean Diet May Boost Eye Health - WebMD, 5/11/09 - "people who ate one serving of fish per week had a 31% lower risk of early signs of AMD. Those who ate one to two servings of nuts rich in omega-3 fatty acids had a 35% lower risk" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Eating Fatty Fish And Marine Omega-3 Fatty Acids May Reduce Risk Of Heart Failure - Science Daily, 4/28/09 - "men who consumed approximately 0.36 grams a day were 33% less likely to develop heart failure than men who consumed little or no marine omega-3 fatty acids"
• Fatty Fish May Lower Heart Failure Risk - WebMD, 4/22/09 - "Study participants who got the equivalent of 0.36 grams of omega-3 a day from fish had a 33% reduction in heart failure risk"
• Eating Fatty Fish And Marine Omega-3 Fatty Acids May Reduce Risk Of Heart Failure - Science Daily, 4/21/09
• Omega-3 Fatty Acids May Benefit Cancer Patients Undergoing Major Operations - Science Daily, 4/10/09 - "A randomised controlled trial showed omega-3 fatty acids given as part of an oral nutritional supplement resulted in the preservation of muscle mass in patients undergoing surgery for oesopahageal cancer, a procedure normally associated with significant weight loss and quality of life issues ... Patients given the standard supplement without omega 3 lost a significant amount of weight comprising 100% muscle mass. In fact 68% of patients suffered ‘clinically severe’ weight loss post surgery in the standard group (without omega 3) versus only 8% in the omega 3 group"
• Resolvins Have Potential To Resolve Periodontal Inflammation And Restore Tissue Health - Science Daily, 4/4/09 - "These results support the hypothesis that both EPA- and DHA-derived Resolvins have therapeutic potential in resolving periodontal inflammation and restoring the tissues' health" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• ALA-DHA conversion negligible, say fatty acids experts - Nutra USA, 3/25/09 - "Alpha-linolenic acid, (ALA) does not convert to docosahexaenoic acid (DHA) at levels that confer any physiological benefit ... Each type of omega-3 has distinct nutritional functions. Nevertheless, seafood/algal omega-3s – also known as long-chain omega-3s – are more potent than terrestrial plant sources of omega-3s and boast certain critical functions that terrestrial plant-based omega-3s simply cannot perform"
• Fatty Fish May Cut Prostate Cancer Risk - WebMD, 3/24/09 - "Men in the study who ate one or more servings of fatty fish a week were found to have a 63% lower risk for developing aggressive prostate cancer than men who reported never eating fish"
• Really? - The Claim - Fish Oil Supplements Can Contain Mercury - NYTimes.com, 3/23/09 - "The concern is a common one, but studies have found that most of the widely available supplements contain little or no mercury, dioxins or PCBs. For one thing, most companies use species of fish that are lower on the food chain, like cod and sardines, which accumulate less mercury. And many companies distill their oils to help remove contaminants"
• Teenage Boys Who Eat Fish At Least Once A Week Achieve Higher Intelligence Scores - Science Daily, 3/9/09 - "Eating fish once a week was enough to increase combined, verbal and visuospatial intelligence scores by an average of six per cent, while eating fish more than once a week increased them by just under 11 per cent"
• Omega-3 Fatty Acids Prevent Medical Complications Of Obesity, Study Suggests - Science Daily, 2/12/09 - "Our study shows for the first time that lipids called protectins and resolvins derived from omega-3 fatty acids can actually reduce the instance of liver complications, such as hepatic steatosis and insulin resistance, in obese people" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Novel Benefits Of Fatty Acids In Arteries Shown - Science Daily, 2/11/09 - "a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. The beneficial actions of fish oil that block cholesterol buildup in arteries are even found at high fat intakes ... the fatty acids contained in fish oil markedly inhibit the entry of "bad," or LDL, cholesterol into arteries and, as a result, much less cholesterol collects in these vessels ... Dr. Deckelbaum advises those interested in increasing omega-3 intakes do so by either increasing fish intake or by using supplements that contain the "long-chain" fatty acids, EPA and DHA, which are found in cold water fish" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Novel Benefits Of Fatty Acids In Arteries Shown - Science Daily, 2/5/09 - "Now, a CUMC research team led by Richard J. Deckelbaum, M.D., Director of the Columbia Institute of Human Nutrition, has found that a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. The beneficial actions of fish oil that block cholesterol buildup in arteries are even found at high fat intakes"
• Omega-3 Fatty Acids Ease Depressive Symptoms Related To Menopause - Science Daily, 1/28/09 - "Their study, published in the February issue of The American Journal of Clinical Nutrition, presents the first evidence that omega-3 supplements are effective for treating common menopause-related mental health problems ... Test results before and after the eight-week period indicate that omega-3s significantly improved the condition of women suffering symptoms of psychological distress and mild depression ... Women with hot flashes also noted that their condition improved after consuming omega-3s. At baseline, the number of daily hot flashes was 2.8 and dropped by an average of 1.6 in the group taking omega-3s and by 0.5 in the control group" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• A Little Wine Boosts Omega-3 In The Body: Novel Mechanism For A Healthier Heart Found - Science Daily, 12/5/08 - "moderate alcohol drinking acts like a 'trigger', boosting the amount of omega-3 fatty acids in our body ... the association was stronger between wine drinking and omega-3 fatty acids levels. This suggests that components of wine other than alcohol is associated with omega-3 fatty acids concentration. We may guess this effect can be ascribed to polyphenols"
• Oily fish may boost prostate cancer survival rate: Study - Nutra USA, 11/24/08 - "The prospective cohort study with 20,167 men also found that men who ate five portions of fish per week had a 48 per cent improved survival rate from the disease than men who consumed only one portion per week" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Diabetes Patients: Fish May Help Kidneys - WebMD, 11/4/08 - "fish consumption lowers abnormal levels of protein in the urine in people with diabetes ... Abnormal amounts of protein appear in the urine when the kidneys are damaged; it's a key indicator of kidney disease ... Leslie Spry, MD, a kidney specialist in Lincoln, Neb., who serves as a National Kidney Foundation spokesman, says he typically doesn't tell patients to eat more fish but recommends fish oil supplements to control triglycerides (blood fats)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• High-fat Diet Could Promote Development Of Alzheimer's Disease - Science Daily, 10/28/08 - "the main neurological markers for Alzheimer's disease are exacerbated in the brains of mice fed a diet rich in animal fat and poor in omega-3s"
• Eating Fish in Infancy Lowers Eczema Risk - WebMD, 9/24/08 - "Babies in a newly published study whose diets included fish before the age of 9 months were 24% less likely to develop eczema by their first birthdays than babies who did not eat fish"
• More fish during pregnancy boosts child development: Study - Nutra USA, 9/22/08 - "The children of mothers who had higher intakes of fish during pregnancy were found to have higher development scores than children of women with low fish intake" - [Abstract]
• 8 natural pain relievers - MSNBC, 9/14/08 - "Capsaicin: For arthritis, shingles, or neuropathy ... InflaThera or Zyflamend: For arthritis ... Aquamin: For osteoarthritis ... SAM-e (S adenosylmethionine): For osteoarthritis ... Fish oil: For joint pain from arthritis or autoimmune disorders ... Methylsulfonyl-methane (MSM): For osteoarthritis"
• Flaxseed Oil Pills vs. Fish Oil Pills - WebMD, 9/12/08 - "As expected, blood levels of EPA and DHA rose in the fish oil group, and ALA rose in the flaxseed oil group. EPA levels also rose in the flaxseed oil group, but only at the higher doses (2.4 to 3.6 grams per day). The researchers write that it's "quite attainable" to get that much ALA from foods without taking supplements ... Since flaxseed oil doesn't contain EPA, the firefighters' bodies must have converted some of the ALA into EPA. That didn't seem to happen at the lower doses of flaxseed oil ... DHA was a different story. The flaxseed oil group didn't get any increase in DHA levels; DHA only rose in the fish oil group"
• Eating Fish While Pregnant, Longer Breastfeeding Lead to Better Infant Development - Doctor's Guide, 9/10/08 - "Both higher fish consumption and longer breastfeeding are linked to better physical and cognitive development in infants"
• Omega-3 Fatty Acids: Mixed Findings for Elderly - WebMD, 9/5/08
• Omega-3 Fatty Acids, but Not Statin Therapy, Cuts Mortality and Hospitalizations in Heart Failure - Medscape, 9/3/08 - "Speaking to the media, Tavazzi said the advantage of n-3 PUFA, as documented by the primary end points, is that they appear to have a beneficial effect on the mechanisms leading to the progression of heart failure. Although the exact reasons are unknown, omega-3 fatty acids could possibly exert favorable effects on inflammatory processes, such as reductions in endothelial activation and cytokine production, as well as influence platelet aggregation, blood pressure, heart rate, ventricular function, and autonomic tone"
• Effects Of N-3 PUFA In Patients With Symptomatic Chronic Heart Failure: The GISSI-HF Results - Science Daily, 8/31/08 - "undertook a randomised, double blind, placebo controlled trial in 357 cardiology sites in Italy. They enrolled 6 975 patients with chronic heart failure of New York Heart Association class II-IV, assigned to n-3 PUFA 1 g daily or placebo. Patients were followed up for a median of 3•9 years ... In a per-protocol analysis performed in about 5000 full complier patients, the relative risk of death was reduced by 14% (p 0.004). Safety was excellent"
• Omega-3 Fatty Acids, But Not Statin Therapy, Cuts Mortality and Hospitalizations in Heart Failure - Medscape, 8/31/08 - "The long-term administration of omega-3 fatty acids reduced all-cause mortality and admission to the hospital for cardiovascular reasons, while there was no effect on these end points with 10-mg rosuvastatin (Crestor, AstraZeneca)"
• Fish oil helps patients with chronic heart failure - MSNBC, 8/31/08 - "Comparing the results from both studies, the researchers concluded that fish oil is slightly more effective than the drug because the oil performed better against a placebo than did Crestor ... Both studies were paid for by an Italian group of pharmaceuticals including Pfizer Inc., Sigma Tau SpA and AstraZeneca PLC"
• Eat Oily Fish At Least Once A Week To Protect Your Eyesight In Old Age - Science Daily, 8/8/08 - "people who habitually consume oily fish at least once a week compared with less than once a week are 50% less likely to have wet AMD. There was no benefit from consumption of non oily white fish. There was a strong inverse association between levels of DHA and EPA and wet AMD. People in the top 25% of DHA and EPA levels (300 mg per day and above) were 70% less likely to have wet AMD" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Eating Fish May Reduce the Risk for Subclinical Brain Abnormalities - Medscape, 8/7/08 - "Dietary intake of tuna and other fish appear to lower the prevalence of subclinical infarcts and white-matter abnormalities ... We also found that broiled and baked fish appeared to be beneficial, while fried fish was not ... The findings add to prior evidence suggesting fish with higher eicosapentaenoic and docosahexaenoic acid content appear to have clinically important health benefits" - See Mega Twin EPA at Amazon.com.
• Fish May Boost Memory, Prevent Stroke - WebMD, 8/4/08 - "Researchers reporting in tomorrow’s issue of Neurology have found that older adults whose diets include three or more weekly helpings of baked or broiled tuna and other fish high in omega-3 fatty acids are less likely to develop "silent" brain lesions that can lead to cognitive decline and vascular stroke"
• Fish Oil, Red Yeast Rice Cut Cholesterol - WebMD, 7/23/08 - "We followed them for a three-month period ... The LDL declined 42% in the supplement group and 39% in the Zocor group ... The supplement group also lost an average of 10 pounds in 12 weeks, but there was no significant weight loss in the medication group. Triglyceride levels, while on average normal in both groups at the start, decreased by 29% in the supplement group but just 9.3% in the medication group -- a significant difference" - See red yeast rice at Amazon.com and Mega Twin EPA at Amazon.com.
• Alpha-linolenic acid reduces risk of nonfatal MI - theheart.org, 7/9/08 - "ALA is an intermediate-chain n-3 polyunsaturated fatty acid that is often overshadowed by the more famous long-chain members of the n-3 family, namely EPA and DHA acids that are found in fish oils ... ALA intake, g/day ... 1.79 ... Relative risk of MI ... 0.43 ... The relationship between ALA and myocardial infarction was nonlinear ... We see a dose effect, but only up to about 0.7% of adipose tissue, which corresponds to about 1.8 g/day. Increasing intake further was not associated with increased protection" - See flax seed at Amazon.com.
• Milestones in Prenatal Nutrition: The Emerging Role of Omega-3 Fatty Acids - Medscape, 7/2/08
• Lowering Blood Cholesterol With Fish Oil And Red Yeast Rice Instead Of Statins - Science Daily, 7/8/08 - "The alternative treatment group participants received daily fish oil and red yeast rice supplements ... The statin group participants received 40 milligrams (mg) of Zocor (simvastatin) daily ... The researchers noted that there was a reduction in LDL cholesterol levels in both groups. The alternative treatment group experienced a 42.4 percent reduction, and the statin group experienced a 39.6 percent reduction. Members of the alternative therapy group also had a substantial reduction in triglycerides, another form of fat found in the blood, and lost more weight" - See red yeast rice at Amazon.com and Mega Twin EPA at Amazon.com.
• Potential Role Of Fish-based Fatty Acids In Resolving, Preventing Asthma - Science Daily, 6/24/08 - "a molecule produced by the body from omega-3 fatty acids helps resolve and prevent respiratory distress in laboratory mice"
• Failure To Bridle Inflammation Spurs Atherosclerosis - Science Daily, 6/18/08 - "When a person develops a sore or a boil, it erupts, drawing to it immune system cells that fight the infection. Then it resolves and flattens into the skin, often leaving behind a mark or a scar ... A similar scenario plays out in the blood vessels. However, when there is a defect in the resolution response -- the ability of blood vessels to recover from inflammation -- atherosclerosis or hardening of the arteries can result ... Some natural mediators that 'cool' this inflammation are derived from omega-3 polyunsaturated fatty acids"
• Pilot study gives sign of fish oil for insulin sensitivity - Nutra USA, 6/18/08 - "The supplements they were given contained 440mg of DHA and 660mg of EPA ... They saw evidence of increased insulin sensitivity through a reduction in the plasma glucose response, and a mean reduction in serum triglycerides and total cholesterol ... What was significant, however, was the reduction in diastolic blood pressure. Clinically significant reductions in all other biomarkers associated with coronary heart disease risk and mortality" - There's no write-up in the abstract.
• Oily Fish Can Protect Against Rheumatoid Arthritis, But Smoking And Psychosocial Stress Increase Its Risk - Science Daily, 6/13/08 - "For the first time, the intake of oily fish has been demonstrated to have a protective effect against the development of RA, reducing an individual's risk by 20-30%"
• Eating Fatty Fish Can Help Aging Eyes - WebMD, 6/10/08
• Eating Fish And Foods With Omega-3 Fatty Acids Linked To Lower Risk Of Age-related Eye Disease - Science Daily, 6/9/08 - "When results from all nine studies were combined, a high dietary intake of omega-3 fatty acids was associated with a 38 percent reduction in the risk of late (more advanced) AMD, while eating fish twice a week was associated with a reduced risk of both early and late AMD ... "Long-chain omega-3 fatty acids, docosahexaenoic acid in particular, form an integral part of the neural retina," the layer of nerve cells in the retina"
• Fish-Oil Supplements Plus Regular Aerobic Exercise Benefit Overweight Patients - Medscape, 5/22/08 - "FO [fish oil] supplements and regular exercise both reduce body fat and improve cardiovascular and metabolic health ... Increasing intake of n-3 FAs could be a useful adjunct to exercise programs aimed at improving body composition and decreasing cardiovascular disease risk"
• Omega-3 linked to lower colorectal cancer risk - Nutra USA, 5/16/08 - "In terms of fish intake, the highest average intake was associated with a 40 per cent reduction in the risk of colorectal cancer. In addition, this link was relevant for both colon and rectal cancers"
• Omega-3 carrier key to boosting children's attention: study - Nutra USA, 5/15/08 - "Test of Variables of Attention (TOVA) scores ... In terms of attention measures, both omega-3 supplemented groups produced increased in TOVA scores, with an increase of 94 per cent in the PL-omega-3 group and 37 per cent in the fish oil group" - [Abstract]
• Diets With High Omega-6:Omega-3 Ratios Enhance Risk for Depression, Inflammatory Disease - Medscape, 4/25/08 - "Whereas the early hunter-gatherers had a dietary omega-6:omega-3 ratio of 2:1 to 3:1, this ratio is now 15:1 to 17:1 in North America today ... It is believed that these dietary changes might be related to increases in inflammatory-related diseases, including depression and cardiovascular disease ... at higher levels of depressive symptoms, as the omega-6:omega-3 ratio increased, there was a marked increase in proinflammatory cytokine levels ... compared with the study participants who did not have syndromal depression, the 6 participants who had depression had significantly higher omega-6:omega-3 ratios and higher levels of proinflammatory cytokines"
• Dietary Fish Oil Has Antiarrhythmic Effects in Ischemic Heart Disease - Medscape, 4/22/08 - "This stabilizing effect may be one way in which fish oil reduces mortality in patients with coronary artery disease"
• Omega-3 EPA may benefit depressives, says study - Nutra USA, 4/7/08 - [Abstract] - "were randomly assigned to receive a daily EPA supplement (1000 mg, supplied by Minami Nutrition, Belgium), or 20 mg fluoxetine daily, or a combination of the two for two months ... At the end of the study, data from the 48 people who finished the study showed a 50 per cent reduction in HDRS scores for people in the EPA group, a 56 per cent reduction in people in the fluoxetin group, and a 81 per cent reduction in people in the combined intervention group"
• Mom's fish intake may boost child's brain power - MSMBC, 4/1/08 - "Preschoolers whose mothers regularly ate low-mercury fish during pregnancy may have sharper minds than their peers ... Oily fish such as tuna, salmon and sardines contain omega-3 fatty acids, which are important in fetal and child brain development. The problem is that fatty fish are more likely to be contaminated with mercury, a metal that is toxic to brain cells, particularly in fetuses and young children"
• Omega-3 Fatty Acids May Be Useful for Cardioprotection - Medscape, 3/18/08 - "To date, the strongest evidence showing a CV benefit from omega-3 fatty acid intake derives from 3 large controlled trials in which a total of 32,000 participants were randomized to a control group or to receive omega-3 fatty acid supplements containing DHA and EPA. In these trials, the supplemented group had a 19% to 45% reduction in CV events vs the control group ... Patients with hypertriglyceridemia should consume 3 to 4 g/day of DHA and EPA, which can lower triglyceride levels by 20% to 50%"
• Fish Diet May Cut Sudden Coronary Death - WebMD, 3/12/08 - "Men who reported eating an average of 6 grams of fatty fish daily -- that's two servings, according to the U.S. Department of Agriculture's serving-size guidelines -- were 55% less likely than men who ate no fatty fish to die of sudden coronary death ... The researchers chalk up the results to the omega-3 fatty acids EPA and DHA" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Cardiovascular Benefits Of Omega-3 Fatty Acids Reviewed - Science Daily, 3/12/08 - "The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from three large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing DHA and EPA or to act as controls ... These trials showed reductions in cardiovascular events of 19 percent to 45 percent ... keeping fish oil capsules in the freezer ... may help reduce burping and upset stomach symptoms" - I've always done the freezer thing and haven't had any problem with the burp even on an empty stomach.  Also note that it's the DHA and EPA that count.  I have friends that buy cheap fish oil capsules that have very low DHA and EPA (omega-3) and they think they are getting a great deal.  I take Jarrow Max DHA at Amazon.com and Jarrow Max DHA at Amazon.com.  They've got the highest percentage of omega-3 that I've found.
• Typical North American Diet Is Deficient In Omega-3 Fatty Acids - Science Daily, 3/7/08 - "the typical North American diet of eating lots of meat and not much fish is deficient in omega-3 fatty acids and this may pose a risk to infant neurological development ... the women who ate lots of meat and little fish were deficient in omega-3 fatty acids, and their babies didn't do as well on eye tests as babies from mothers who weren't deficient. The results were noticeable as early as two months of age"
• Farmed Fish Fed Cheap Food May Be Less Nutritious For Humans - Science Daily, 2/26/08 - "Vegetable oils have been shown to stimulate the appetite and feed intake of fish, and to increase growth rate and carcase quality ... Marine oils are rich in long-chain omega-3 fatty acids (EPA and DHA), which have been shown to have beneficial effects on heart and circulatory system disease in man ... heart patients with atherosclerosis (disease of the cardiac arteries) were placed on three different diets, using salmon meat containing varying amounts of fish oil and vegetable oil. It was shown that the fat composition of the salmon meat affected the fatty acid profile of the patients’ blood and that the advantageous marine omega-3 fatty acids increased markedly in those patients that ate fish fed on feed containing pure fish oils. It was also shown that in these patients the levels of marker substances for heart and vessel disease were much better than in patients eating fish fed pure rapeseed oil"
• Consumption of fish/fish oil associated with specific heart-rate variability parameters - theheart.org, 2/21/08 - "fish and omega-3 fatty-acid consumption are associated with "more optimal" values of various heart-rate variability (HRV) indices" - [Abstract]
• Essential Fatty Acid Accelerates Treatment Response in Early Psychosis - Medscape, 1/22/08 - "For the primary and secondary prevention of emerging psychotic disorders, physicians should "keep an open mind towards neuroprotective substances, such as omega-3 fatty acids or other experimental neuroprotective substances,""
• Alpha-Linolenic Acid May Lower Risk of Diabetic Peripheral Neuropathy - Medscape, 1/7/08 - "Alpha-linolenic acid is an omega-3 fatty acid found in many vegetable oils, including flaxseed, walnuts, and canola oil ... Relative to adults in the lowest quintile of alpha-linolenic acid intake (< 0.61 g/day), the multivariate-adjusted odds of having peripheral neuropathy was 0.54 for subjects in the fourth quintile (1.35 - 2.10 g/day) of intake and 0.40 for adults in the fifth quintile (2.11 g/day or higher)" - See flax seed at Amazon.com.
• More support for omega-3 and weight management - Nutra USA, 12/21/07 - "Laboratory mice fed a high fat diet and supplemented with eight per cent fish oil gained less weight and metabolised more fat than their murine counterparts not receiving the supplement" - [Abstract]
• How Much Fish Is Enough? - Medscape, 12/19/07 - "the American Heart Association recommends the equivalent of 1 gram of active omega-3 compounds (eicosapentaenoic [EPA] and docosahexaenoic acids [DHA]) ingested daily.[3] This amount can be obtained by consuming a 4-ounce serving of white albacore tuna, 2 to 3 ounces of salmon (pink or red), 2 ounces of herring, and 2 to 3 ounces of sardines daily. Alternatively, significantly higher quantities of shellfish would need to be consumed, including 8 or more ounces of crab, shrimp, and lobster daily.[3] For significant TG-lowering effects (20% reduction and greater), the amount of EPA/DHA required is considerably higher (ie, 2 to 4 grams daily) and exceedingly difficult to obtain unless a person consumes vast quantities of fish every day. Therefore, patients with CHD can get the omega-3 fatty acids needed from a diet rich in oily fish. Similarly, patients with TG levels in the borderline-elevated range (150-199 mg/dL) may reduce TG levels by approximately 10% with consumption of fish equivalent to 1 gram of EPA/DHA. However, with higher TG levels, and especially when levels exceed 500 mg/dL, a diet rich in fish is most likely to be insufficient for reducing TG levels to an acceptable range"
• Omega-3 shows benefits for fat loss in diabetics - Nutra USA, 12/13/07 - "either daily supplements of fish oil (three grams, providing 1.8 grams of omega-3) or placebo (paraffin oil) for two months ... At the end of the study, Kabir and co-workers report significant reductions in total fat mass and the diameter of fat cells beneath the surface of the skin (subcutaneous adipocytes) in the omega-3, but not the placebo, group ... risk factors for plaque formation in the arteries (atherogenic markers), such as triacylglycerol levels and the ration of triacylglycerol to HDL ('good') cholesterol, were significantly lower as a result of omega-3 supplementation" - [Abstract]
• Omega-3 Fatty Acids Protect Against Parkinson's, Study Says - Science Daily, 11/26/07 - "Omega-3 fatty acids protect the brain against Parkinson's disease ... omega-3 fatty acids--in particular DHA (docosahexaenoic acid), a specific type of omega-3--had replaced the omega-6 fatty acids already present in the brains of the mice that had been given omega-3 supplementation" - See Jarrow Max DHA at Amazon.com.
• The Ethyl Ester vs. Triglyceride Form of Fish Oils - Dr. Murray's Natural Living, 11/21/07 - "Some fish oil products are made by synthesizing the free fatty acids back to a triglyceride form while others, including the pharmaceutical forms, maintain the purified oil in the ethyl ester (EE) form. Some companies selling fish oils claim that the triglyceride form is more natural, has better stability, and is better absorbed than the EE form. None of these claims is true. The recombined triglycerides are not necessarily in their natural form, they are not more stable, and they certainly are not better utilized by the body. My personal opinion is that the EE form actually possesses some advantages: ... The specific fish oil product that I recommend is RxOmega-3 Factors from Natural Factors" - See RxOmega-3 products at Amazon.com.
• Fish for brain health supported by trio of studies - Nutra USA, 11/14/07 - "These recent reports are novel in that they address the association of n-3 fatty acid intake and cognitive function in non-demented individuals and, thus, present a shift in the attention to earlier stages of cognitive decline with the hope of preventing progression to states of dementia and disability before they become irreversible"
• Eating Fish, Omega-3 Oils, Fruits And Veggies Lowers Risk Of Memory Problems - Science Daily, 11/13/07 - "people who regularly consumed omega-3 rich oils, such as canola oil, flaxseed oil and walnut oil, reduced their risk of dementia by 60 percent compared to people who did not regularly consume such oils ... people who ate fish at least once a week had a 35-percent lower risk of Alzheimer's disease and 40-percent lower risk of dementia, but only if they did not carry the gene that increases the risk of Alzheimer's, called apolipoprotein E4, or ApoE4 ... Given that most people do not carry the ApoE4 gene, these results could have considerable implications in terms of public health"
• Omega-3 Fish Oil Improves Lupus Symptoms, Shows Possible Cardiovascular Benefits - Doctor's Guide, 11/12/07 - "They received 3 grams of omega-3 fish oils, daily, for 24 weeks ... Low dose dietary supplementation with omega-3 fish oils in SLE not only has a therapeutic effect on disease activity but also improves endothelial function and reduces oxidative stress and may, therefore, confer cardiovascular benefits" - See Mega Twin EPA at Amazon.com.
• Got omega-3? Not so much - USATODAY.com, 11/11/07 - "Most mayonnaise is made with soybean oil, which is a source of ALA (alpha-linolenic acid). But that kind of omega-3 fat, found most abundantly in flaxseed, has not been proven to convey the same health benefits as DHA plus EPA ... if the label just says omega-3 and makes no mention of DHA and EPA, there's a good chance it's ALA"
• Eat Fish, Get Smarter? - WebMD, 11/8/07 - "Most participants ate fish, and the more fish they ate, the better their test scores were -- up to a point ... Test scores leveled off for people who ate more than about 2.5 to 2.8 daily ounces of fish" - Note:  The article includes a total of three studies.
• Staving Off Alzheimer's Disease With The Right Diet, Prescriptions - Science Daily, 11/7/07 - "Fish oil elevated the level of a protein that prevents the formation of amyloid, the tell-tale protein found in Alzheimer's. Caffeine reversed memory impairment in animal models of the disease. In addition, environmental copper reduced the clearance of amyloid, from the brain to blood ... scientists have identified ways that essential omega-3 fatty acid -- docosahexaenoic acid (DHA) or fish oil -- can help prevent Alzheimer's ... DHA also reduced pro-inflammatory arachidonic acid in brains of Alzheimer's model mice, consistent with the anti-inflammatory effects of non-steroidal anti-inflammatory drugs (NSAIDs) that are associated with reduced Alzheimer's in people" - See Jarrow Max DHA at Amazon.com.
• Fish Oil Supplements May Ease Lupus - WebMD, 11/7/07 - "Fish oil supplements may help improve the symptoms of lupus ... the supplements also improve blood flow and blood vessel function in people with lupus who are known to be at increased risk for heart disease"
• Fish May Be Adjunct for Postpartum Depression - Clinical Psychiatry News, 11/07 - "The only study of omega-3 fatty acid supplements given specifically for postpartum depression was a dose-ranging study in 16 women. It found significant and similar reductions in depression in each of three dosage groups; patients received between 500 mg and 2.8 g per day of supplement capsules for 8 weeks"
• Omega-3 to cut colon cancer: meta-analysis - Nutra USA, 10/25/07 - "the highest consumption of fish oil was associated with 12 per cent reduction in the incidence of colorectal cancer" - [Abstract] - See Mega Twin EPA at Amazon.com.
• Recurrence of Atrial Fibrillation Reduced With Alpha-Linolenic Acid-Enriched Diet - Doctor's Guide, 10/17/07 - "The survival rate was 25.52% in the control group versus 63.09% in the ALA group at the end of the 12-month period" - Note:  ALA is the shorter chain omega-3 found in vegetable sources such as flaxseed.
• Baby Formula WIth Fish Oil Added May Help Infants - Science Daily, 10/11/07 - "The researchers noticed that in the piglets that were fed the control formula, fewer proteins were produced in their body over time and, at the same time, their insulin became less effective at lowering blood sugar levels. But piglets that drunk the test formula showed increased protein production and their insulin was as effective at using the proteins in the test formula for their growth as when they were born"
• Vitamin C May Slow Skin Wrinkling - WebMD, 10/8/07 - "After adjusting for other factors likely to influence skin aging, such as sun exposure and smoking, vitamin C and linoleic acid were independently associated with skin aging ... After digestion, linoleic acid is converted to DHA and EPA -- two fatty acids" - See vitamin C products at Amazon.com and Mega Twin EPA at Amazon.com. - Note:  I'm not sure that is correct.  Linoleic acid is an omega-6, which is not converted to DHA and EPA.  Most Americans get about ten time too much omega-6 already.
• Omega-3 Fatty Acids and Borderline Personality Disorder - Clinical Psychiatry News, 10/07 - "Omega-3 fatty acids may be effective for reducing aggression and depression in females who suffer with moderate BPD. The results are consistent with prior findings on the efficacy of omega-3 fatty acids in the treatment of depression (Evidence-Based Psychiatric Medicine, CLINICAL PSYCHIATRY NEWS, May 2005, p. 28)"
• Report: Fighting Depression And Improving Cognition With Omega-3 Fatty Acids - Life Extension Magazine, 10/07 - "subjects were randomly assigned to receive 1200 mg EPA plus 900 mg DHA, or placebo, for 12 weeks. At the end of the treatment period, the group receiving omega-3 fatty acids had significantly greater improvements compared with the placebo group in scores for depression, suicidality and daily stresses"
• Omega-3 May Lower Type 1 Diabetes Risk - WebMD, 9/25/07 - "Eating a diet rich in omega-3 fats may help keep high-risk children from developing type 1 diabetes"
• Omega-3 may boost blood vessel elasticity - study - Nutra USA, 9/21/07 - "fish oil supplementation improved large artery elasticity, compared to placebo (15.51.5 versus 12.83.7 ml.mm.Hg-1 x 10, respectively)"
• Omega-3 Can Prevent Blindness In Premature Mice: Hospital Treatment Soon? - Science Daily, 8/18/07 - "Mice that ate omega-3 initially lost fewer blood vessels in their retinas than mice that ate omega-6, and they evinced only half as much abnormal vessel growth. Their retinas also showed lower inflammatory activity"
• More Fish Oil, Less Vegetable Oil, Better For Your Health - Science Daily, 7/26/07 - "using more fish oil than vegetable oil in the diet decreases the formation of chemicals called prostanoids, which, when produced in excess, increase inflammation in various tissues and organs"
• Different omega-3 may offer different colorectal protection - Nutra USA, 7/11/07 - "Increased intake of EPA was associated with a 41 per cent reduction in risk, while DHA was associated with a 37 per cent reduction in risk, comparing highest against lowest average intakes" - [Abstract]
• Omega-3s May Help Prevent Blindness - WebMD, 6/25/07
• Can Blindness Be Prevented Through Diet? - Science Daily, 6/24/07 - "Increasing intake of the omega-3 fatty acids DHA and EPA, found in popular fish-oil supplements, may protect against blindness resulting from abnormal blood vessel growth in the eye ... Mice on the omega-3 diet, rich in DHA (docosahexaenoic acid) and its precursor EPA (eicosapentaenoic acid), had less initial vessel loss in the retina than the omega-6-fed mice: the area with vessel loss was 40 to 50 percent smaller"
• Omega-3 Fatty Acids May Help Slow Prostate Cancer Growth - Science Daily, 6/21/07
• Omega-3 Fatty Acids May Lower Genetic Risk for Prostate Cancer - Medscape, 6/21/07 - "Overall, diets rich in omega-3 fatty acids reduced prostate tumor growth, slowed histopathological progression, and increased survival, the researchers write. The 12-month survival rate was 60% for mice fed a diet high in omega-3, 10% on the low–omega-3 diet, and 0% on the high–omega-6 diet. The ideal ratio of omega-6 to omega-3 fatty acids is 1:1, and mice fed diets with this ratio of fatty acids were able to delay both the formation and progression of prostate tumors and prolong their survival"
• Omega-3 Supplements Can Help With Alzheimer's Symptoms, Study Suggests - Science Daily, 6/21/07 - "There was no observable difference in therapeutic effect between the patients receiving the omega-3 and the placebo group. However, when the researchers took into account which of the patients carried the susceptibility gene APOE4 and which did not, an appreciable difference appeared. Carriers of the gene who had received active treatment responded positively to the omega-3 as regards agitation symptoms, while non-bearers of the gene showed an improvement in depressive symptoms"
• Omega-3s May Lower Blood Pressure - WebMD, 6/4/07 - "Participants with the highest intake of omega-3 fatty acids tended to have the lowest blood pressure"
• Eating Fish May Preserve Eyesight - WebMD, 5/15/07
• Higher Intake Of Fish And Vitamin D Levels Linked To Lower Risk Of Age-related Macular Disease - Science Daily, 5/14/07 - "Individuals who have higher dietary intake of foods with omega-3 fatty acids and higher fish consumption have a reduced risk of advanced age-related macular degeneration, while those with higher serum levels of vitamin D may have a reduced risk of the early stages of the disease"
• Marine Omega-3 Fatty Acids Have Positive Effect On Muscle Mass, Study Shows - Science Daily, 5/9/07 - "In mammals, the ability to use nutrients from food and convert them into muscle proteins decreases with age. Though the exact cause of this phenomenon is still unclear, insulin resistance of aging muscle cells has been suggested as a possible answer ... omega-3 fatty acids are known to improve glucose metabolism in people and animals showing insulin resistance ... After five weeks, animals with the marine omega-3 diet showed increased sensitivity to insulin which, in turn, improved protein metabolism"
• Preventing Breast Cancer? - Dr. Weil, 5/3/07 - "Take 2 grams of fish oil a day. High omega-3 fatty acid intake significantly reduces your risk of breast cancer"
• Fish Oil May Help Kidney Disease Sufferers - Science Daily, 4/30/07 - "daily doses of fish oil in the form of a tablet or liquid had been shown to decrease inflammation - a common problem in people with kidney disease"
• Fish-diabetes pollution link may boost supplements - Nutra USA, 4/13/07 - "the risk of pollutants from oily fish, such a methyl mercury, dioxins, and polychlorinated biphenols (PCBs) have led to some claims to reduce fresh fish intake, especially for pregnant women who may damage the development of their babies ... Most extracted fish oils are molecularly distilled and steam deodorised to remove contaminants ... The study, led by Professor Duk-Hee Lee observed a link between POP levels and diabetes"
• Fish Oil: Getting to the Heart of It - Medscape, 4/12/07 - "A food-based approach to increasing intake of omega-3 fatty acids is preferable. However, for those with known CHD, the increased dose required to lower triglycerides could be as much as 4 g/day. Consuming fish 2.5 to 3 times a week would provide a combined intake of about 500 mg EPA and DHA/day.[21] It is unrealistic to think that these high daily doses could be achieved through diet alone, resulting in a requirement for supplementation"
• Omega-3 Fatty Acid May Protect Heart - WebMD, 3/29/07 - "2.8% of those taking EPA along with statins experienced a major coronary event, compared with 3.5% of those only taking statins ... That's a 19% difference"
• Supplement 'boosts' brain power - BBC News, 3/12/07 - "they were given two capsules a day of the VegEPA supplement, which contains an omega-3 fatty acid called EPA ... Tests done at the end of the three-month study found the children showed an increase in reading age of well over a year, their handwriting became neater and more accurate and they paid more attention in class ... In three months you might expect to see a small NAA increase ... But we saw as much growth as you would normally see in three years"
• Omega-3 in fish oils might ease depression - USA Today, 3/6/07 - "The more DHA a person consumed, the more gray matter there was in three areas of the brain linked to mood: the amygdala, the hippocampus and the cingulate, Conklin says. Seriously depressed people tend to have less gray matter in these areas" [WebMD]
• Balancing Omega-3 and Omega-6? - Dr. Weil, 2/22/07 - "Many nutrition experts believe that before we relied so heavily on processed foods, humans consumed omega-3 and omega-6 fatty acids in roughly equal amounts. But to our great detriment, most North Americans and Europeans now get far too much of the omega-6s and not enough of the omega-3s. This dietary imbalance may explain the rise of such diseases as asthma, coronary heart disease, many forms of cancer, autoimmunity and neurodegenerative diseases, all of which are believed to stem from inflammation in the body. The imbalance between omega-3 and omega-6 fatty acids may also contribute to obesity, depression, dyslexia, hyperactivity and even a tendency toward violence"
• Omega-3 and joint health – more support - Nutra USA, 1/31/07 - "randomly assigned 24 patients with ankylosing spondylitis (AS), also known as Bechterews disease, to receive either high-dose (4.55 g) or low-dose (1.95 g) daily supplement of omega-3 (Epax 5500 TG) ... The patients in the high-dose group exhibited a significant decrease in disease activity according to the Bath Ankylosing Disease Activity Index, which was not seen in the low-dose group" - [Abstract]
• Fish Oil for Moms May Benefit Babies - WebMD, 12/21/06 - "children of mothers who took fish oil supplements scored significantly higher on tests of hand-eye coordination than those who took olive oil supplements"
• More support omega-3 may protect against colorectal cancer - Nutra USA, 11/22/06 - "A diet rich in omega-3 polyunsaturated fatty acids (PUFAs) could reduce the risk of colorectal cancer by 85 per cent"
• Soy, Fish May Cut Cancer Risk - WebMD, 11/14/06 - "men who ate the most fish -- and that was five or more servings per week of fish -- compared to the least fish -- less than one time per week -- had a 40% lower risk of developing colorectal cancer"
• Omega fatty acids to stop mental decline, says study - Nutra USA, 10/31/06 - "ARA plus DHA supplementation produced significant improvements in the immediate memory and attention RBANS scores (eight and five points, respectively)"
• Omega 3 Fatty Acid Prescribing Behaviors - Medscape, 10/25/06 - "Fish oil intake, through diet or supplementation, is recommended by the AHA and can potentially reduce mortality in patients with CVD. Despite this, family physicians do not often advise increasing dietary fish intake to their patients with CVD. Improving physician awareness of fish oil's benefits on sudden death and simplifying the message should be explored further as potential strategies to increase physician recommendation of this important advice"
• Omega-3 Fatty Acids May Slow Cognitive Decline In Some Patients With Very Mild Alzheimer's Disease - Science Daily, 10/11/06 - "For six months, 89 patients (51 women and 38 men) took 1.7 grams of docosahexaenoic acid (DHA) and .6 grams of eicosapentaenoic acid (EPA), while 85 patients (39 women and 46 men) took placebo ... among a subgroup of 32 patients with very mild cognitive impairment at the beginning of the study, those who took the fatty acids experienced less decline in six months compared with those who took placebo"
• New Study Finds Omega-3's in Fatty Fish Can Reduce Risk of Cancer - Doctor's Guide, 9/26/06 - "At least one portion of fatty fish a week during the period (1987-2004) reduced the risk of renal cancer by 74 per cent compared with those who never ate fatty fish"
• Fatty Fish Fight Cancer - WebMD, 9/19/06 - "Those who consistently ate lots of fatty fish over a 10-year period had a 74% lower risk of kidney cancer" - See Mega Twin EPA at Vitacost or iHerb.
• Why You Need More Omega-3 Fatty Acids - Life Extension Magazine, 9/06
• Protection for Aging Eyes - New Hope Natural Media Online, 8/31/06 - "A 40% reduction in the incidence of early age-related macular degeneration was associated with eating fish at least once a week; eating fish at least three times per week even reduced the incidence of late-stage age-related macular degeneration"
• Fish Oils May Be Lifesavers - WebMD, 8/30/06 - "Sudden death risk dropped 6.4% with adequate omega-3 fatty acid intake, compared with 3.3% for implantable defibrillators, and less than 1% with easy access to AEDS"
• Omega-3 Fatty Acids after Myocardial Infarction - Medscape, 8/30/06 - "OMACOR, containing 900 mg of highly purified n-3 PUFA (eicosapentaenoic acid, 46%; decosahexaenoic acid, 38%) ... The incremental number of life-years saved by OMACOR during the 4 years' follow-up was 0.054 per patient, or 54 per 1000 patients"
• Altering Fatty Acid Levels In Diet May Reduce Prostate Cancer Growth Rate - Science Daily, 8/1/06 - "tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids"
• Fatty Fish Helps Heart Keep Its Rhythm - WebMD, 7/28/06 - "suggests eating fish rich in omega-3 fatty acids regularly acts directly on the heart's electrical function, which regulates the heart rate and keeps it from beating too fast or too slow"
• Fish Oil May Help Save Your Eyes - WebMD, 7/10/06 - "men with the highest fish consumption (at least two weekly servings) were 45% less likely to have AMD than those with the lowest fish consumption (less than one weekly serving)"
• A Safer Alternative to NSAIDs? - Physician's Weekly, 7/3/06 - "omega-3 essential fatty acid (EFA) may be as effective as nonsteroidal anti-inflammatory drugs (NSAIDs) in relieving neck and lower back pain without the risk of harmful complications"
• Omega-3s may help depressive kids - pilot study - Nutra USA, 6/23/06 - "seven out of ten children in the omega-3 group and none of the children in the placebo group had depression score reductions of 50 per cent or more"
• Hypertriglyceridemia - Medscape, 6/1/06 - "Omega-3 fatty acids (4 g per day) will reduce triglyceride levels by 30%"
• MIT Research Offers New Hope For Alzheimer's Patients - Science Daily, 4/27/06 - "The three compounds in the treatment cocktail - omega-3 fatty acids, uridine and choline - are all needed by brain neurons to make phospholipids, the primary component of cell membranes"
• Does Eating Salmon Lower the Murder Rate? - New York Times, 4/16/06 - "enrolled 231 volunteers at a British prison in his study; one-half received a placebo, while the other half received fatty acids and other supplements. Over time, the antisocial behavior (as measured by assaults and other violations) of the inmates who had been given the supplements dropped by more than a third relative to their previous records"
• Fish Oil May Help Ease Back Pain - WebMD, 4/6/06 - "88% of patients said they would keep taking fish oil supplements"
• Fish Oil May Help Protect Against Retinal Degenerative Diseases - Science Daily, 4/6/06
• Omega-3s could stop liver cancer cells growth - Nutra USA, 4/3/06 - "Both omega-3 fatty acids had a dose-dependent inhibitory effect"
• Study: Benefits of Omega-3s Fishy - WebMD, 3/24/06
• In search of those omega-3 fatty acids -  San Diego Union-Tribune, 3/7/06 - "Fish oils from supplements or dietary sources can reduce triglycerides by 20 percent to 50 percent ... Studies have used triglyceride-lowering doses of 1 to 4 grams (1,000 mg to 4,000 mg) daily"
• In a Bad Mood? Eat Your Fish - WebMD, 3/3/06 - "People in our study who had low blood levels of omega-3 fatty acids were more likely to report mild to moderate symptoms of depression, more moodiness, and more impulsivity ... people with higher blood levels of omega-3s were found to be more agreeable"
• Fish oils cool anger levels - Nutra USA, 1/23/06 - "The 13 patients who received the fish oil showed a clinically significant and progressive decrease in their POMS anger subscale scores"
• Oily fish makes 'babies brainier' - BBC News, 1/20/06 - "mothers with the lowest intake of the essential fatty acid had children with a verbal IQ six points lower than the average ... Low intake of the crucial fatty acid also appeared to lead to more problems of social interactions - such as an inability to make friends"
• Fish Oil Reduces Airway Inflammation Caused by Exercise-Induced Asthma - Doctor's Guide, 1/10/06 - "the post-exercise lung function of participants -- adults with mild-to-moderate persistent asthma -- improved by about 64% and their use of emergency inhalers decreased by 31% when they consumed a diet supplemented with fish oil, rich in omega-3 polyunsaturated fatty acids (n-3 PUFA), for three weeks"
• Have a Daily Dose of Omega-3 - US News, 12/26/05 - "Farmed salmon are raised on fish oil pellets derived from local fish, which are often contaminated with cancer-causing PCB s. The most recent study, in the November issue of the Journal of Nutrition, reports that contaminant levels in farmed salmon from certain regions increase the risk of cancer enough to outweigh benefits"
• Fish Oil Prevents Potentially Deadly Heart Rate Variability - Science Daily, 12/15/05 - "In this randomized controlled trial, fish oil supplementation prevented the reduction in heart rate variability associated with the same-day exposure to indoor particulate matter"
• Fish Oil May Treat Lung Disease - WebMD, 12/12/05 - "People in the omega-3 group had two advantages. They had a significant drop in lung inflammation. They also walked farthest in the six-minute walking test"
• Cortisol, Stress, and Health - Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3 fatty acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ... Rhodiola rosea: 100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day, standardized extract ... DHEA: 25-50 mg/day (any hormone supplementation should be monitored by your physician)"
• Fatty Acids May Protect against Cardiovascular Disease - Doctor's Guide, 11/21/05 - "After 4.5 years of follow-up, patients taking EPA were 19% less likely to have adverse coronary events compared to controls"
• The Nude Mouse Tale: Omega-3 Fats Save The Life Of A Terminal Cancer Patient - Science Daily, 11/14/05 - "In 2000 he was told by his doctor he had only a few months to live ... But five years later, he is still alive, and has even gained a little weight ... It was a nutritional intervention, drastically increasing the patient’s intake of omega-3 fatty acids"
• Fish Oil Supplements Improve Lipid Risk Factors in Obese Children - Medscape, 11/14/05 - "given 3 g of a daily fish oil supplement ... After 12 weeks, the researchers found that triglyceride levels in the control group did not significantly differ from baseline. In contrast, triglyceride levels in children treated with fish oil significantly decreased. However, differences in other lipid measures were not statistically significant"
• The Perricone Weight Loss Program - Life Extension Magazine, 11/05 - "The reason that traditional low-calorie diets fail is that they lack omega-3s, which are essential for healthy metabolism. If you follow the anti-inflammatory diet and ensure the intake of plenty of omega-3 fatty acids, you will successfully lose weight"
• Oxidation Negates Fish Oil's Many Benefits - mercola.com, 10/31/05
• Fish Oil Improves Endothelial Function of Healthy Subjects - Doctor's Guide, 10/27/05 - "fish oil supplementation resulted in a significant increase in endothelium-dependent brachial artery flow mediated vasodilation (EDV) and endothelium-independent nitroglycerin mediated vasodilation (EIDV)"
• Fatty Acid Supplementation for ADHD - Medscape, 10/26/05 - "finally studies are emerging that are evaluating these possible benefits. One such study found significant improvements in reading, spelling, and behavior in a cohort of children who received dietary supplementation with omega-3 and omega-6 fatty acids.[1] In addition, studies of infants fed infant formula with fatty acid supplementation have suggested cognitive enhancement into the second year of life"
• Dietary Fat Intake Linked To Dry Eye Syndrome In Women - Science Daily, 10/24/05 - "a high intake of omega 3 fatty acids, often referred to as a 'good' fat, commonly found in fish and walnuts, is associated with a protective effect. Conversely, a higher ratio of omega 6, a fat found in many cooking and salad oils and animal meats, compared to omega 3 in the diet, may increase the risk of dry eye syndrome"
• Eating Fish Associated with Slower Cognitive Decline - Doctor's Guide, 10/12/05 - "Consuming fish at least once a week was associated with a 10% per year slower rate of cognitive decline in elderly people ... consumption of one omega-3 fatty acid in particular, docosahexaenoic acid (DHA), is important for memory performance in aged animals" - See DHA products at iHerb.
• Balance of Essential Fats May Prevent Bone Loss After Menopause - Doctor's Guide, 7/13/05 - "After 12 weeks, rats with the lowest ratio of omega-6 to omega-3 fatty acids in their diet experienced significantly less bone loss than rats in the other dietary groups ... A 5-to-1 dietary ratio of omega-6 to omega-3 fatty acids led to a conservation of bone mineral content that we didn't see with a 10-to-1 ratio"
• Omega-3, Omega-6 Fatty Acids Can Affect Bone Loss - CBS 2 Chicago, 7/12/05 - "eating foods rich in omega-3 fatty acids -- found in walnuts and salmon -- may prevent bone thinning. While excess amounts of omega-6 -- found in grains and beef -- may actually promote bone loss ... a low ratio of omega-6 to omega-3 appears to be best"
• Getting Enough Omega-3? - Dr. Weil, 7/14/05
• Fish Help the Heart by Fighting Inflammation - WebMD, 7/5/05 - "compared with those who said they didn't eat fish, those who ate at least 10.5 ounces of fish per week had 33% lower C-reactive protein and 33% lower tumor necrosis factor-alpha (another indicator of inflammation) levels as well as much lower levels of other signs of inflammation"
• Omega-3 Offers Hope For New Anti-breast Cancer Drugs - Science Daily, 6/8/05 - "Compounds of Omega-3 fatty acids and propofol reduce the ability of breast cancer cells to develop into malignant tumours, inhibiting cancer cell migration by 50% and significantly reducing their metastatic activity ... Propofol is a potent anti-oxidant known to inhibit cancer cell migration by only 5-10%"
• Modern diet may be causing depression - Nutra USA, 5/26/05 - "The finding lends itself nicely to the theory that increased omega-3 fatty acid intake may shift the balance between the two fatty acid families in the brain, since it has been demonstrated in animal studies that increased omega-3 fatty acid intake may result in decreased brain arachidonic acid"
• Omega-3 Boosts Mood Throughout Pregnancy - Clinical Psychiatry News, 5/05 - "In a small, open-label, flexible-dose study of 15 patients using doses up to 2.8 g/day of the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid, patients showed a mean decrease on the Edinburgh Postnatal Depression Scale (EPDS) of 39% and a mean decrease of 34% on the Hamilton Rating Scale for Depression"
• Omega-3 Fatty Acids and Depression - Clinical Psychiatry News, 5/05 - "English investigators conducted a 12-week, double-blind, placebo-controlled trial evaluating the efficacy of EPA doses of 1,000, 2,000, or 4,000 mg/day in addition to unchanged standard treatment in 70 patients with persistent depression. The 1,000-mg group showed a significant decrease in depression as compared with placebo, but the other groups showed little evidence of efficacy ... The bulk of evidence suggests that omega-3 fatty acid supplementation is effective in treating depression in patients with low omega-3 diets"
• Breast Cancer Protection Starts in the Womb - WebMD, 4/20/05 - "Mothers who choose foods packed with omega-3 fatty acids during pregnancy and while nursing and then feed their kids such a diet after weaning may reduce the risk of breast cancer in their daughters by nearly 90%, early research in mice indicates"
• High-Dose Omega-3 Oils Used to Treat Non-Surgical Neck and Back Pain - Doctor's Guide, 4/20/05 - "this could be the answer to the adverse effects seen with nonsteroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase (COX)-2 inhibitors, which have been associated with potentially catastrophic adverse effects ... 88% percent said they were pleased enough with the outcomes that they planned to continue using the fish oils"
• Fish, Soy Oil Supplements May Cut Heart Death - WebMD, 4/11/05 - "participants were randomly assigned to take fish oil supplements or soy oil pills (2 grams daily for both groups) for 11 weeks ... Both groups significantly increased their heart rate variability while taking the supplements. Greater heart rate variability reduces the risk of dangerous irregular heart beats or sudden death"
• Fish Oil May Fight Alzheimer's Disease - WebMD, 3/22/05 - "Brain imaging showed that the high-DHA diet cut brain plaque by 40%. The largest drops were seen in brain areas vulnerable to Alzheimer's disease ... The high-DHA diet also delivered the biggest drop (70%) in levels of beta-amyloid protein in the brain, a building block of plaque"
• The Mechanism of Action of Omega-3 Fatty Acids - Medscape, 3/16/05 - "omega-3 fatty acids play a significant role in secondary prevention post-myocardial infarction. The mechanisms through which two of these omega-3 fatty acids, eicosapentaenoic acid and docosahexanoic acid, exert their action appear to be distinct and adjuvant to the available standard secondary prevention therapies"
• Eating Oily Fish May Reduce Inflammation - Science Daily, 3/24/05 - "This research group recently identified a new class of aspirin-triggered bioactive lipids, called resolvins, the activity of which may in part explain the beneficial effects of omega-3 fatty acids"
• Oily fish helps cut inflammation - BBC News, 3/13/05 - "We always suggest that people with arthritis eat two or three portions of oily fish a week, or take 1,500mg fish oil capsules a day"
• Low Fatty Acid Levels, Dementia Associated in Large Study - Clinical Psychiatry News, 3/05 - "The n-3 fatty acids are an important component of the neuronal membrane, influencing membrane fluidity and all the related functions, such as signal transduction and enzyme function ... Subjects with dementia had the lowest n-3 fatty acid plasma concentrations ... Subjects with dementia had the highest plasma concentrations of saturated fatty acids"
• Applications of Omega-3 Fatty Acids - Medscape, 3/1/05 - "Fish saves lives, and physicians must recognize this potential life-saving treatment choice in patients with cardiovascular disease. In addition, family physicians can safely offer patients an alternative therapeutic approach for difficult-to-treat conditions such as hypertriglyceridemia and rheumatoid arthritis. For those without cardiovascular disease, including young mothers and women, it is reasonable to recommend 650 to 1000 mg of low-risk fish oils per day through dietary approaches as suggested by the National Institutes of Health working group, AHA, and the FDA—easily achieved by 1 to 2 fatty fish meals per week"
• Antidepressant Foods - Forbes.com, 2/10/05 - "The Omega-3 diet showed results after one month, and uridine was effective as long as the rats were fed enough of it. But when given both together, within ten days the rats who were eating the good foods behaved as well as those on medications ... Uridine fuels mitochondria, and paired with the lubricating effect of the Omega-3s, helps them make more energy more efficiently"
• Omega-3s to enter weight loss category? - Nutra USA, 1/25/05 - "The fish oil concentrates not only caused weight reduction in the mice but they also appeared to stop the animals from gaining weight when given free access to food"
• Arthritis Patients Can Seek Natural Pain Relief - CBS Chicago, 1/15/05 - "They placed 120 patients on fish oil supplements. About 59 percent of reported decreased joint pain, and 68 percent were able to discontinue prescription drugs entirely"
• Fish oil supplements slow ageing of brain - Nutra USA, 12/21/04 - "People who eat oily fish or take fish oil supplements score 13 per cent higher in IQ tests and are less likely to show early signs of Alzheimer’s disease ... The brains of fish oil users seemed to be faster. There was a strong relationship between mental test scores and the omega-3 content in the blood"
• Fish Oil Could Help Crohn's Disease - WebMD, 12/10/04
• Low-Fat Diet May Protect Against Alzheimer's - WebMD, 12/7/04 - "mice fed a low-fat diet rich in the omega-3 fatty acids found in fish and soy, produced more of a protein that helps eliminate the amyloid peptides that cause plaque in the brain"
• The high five for hypertension - Functional Foods & Nutraceuticals, 12/04 - "Co-enzyme Q10 ... Omega-3 fatty acids ... Garlic ... L-arginine ... Calcium"
• Alpha-Linolenic Acid Intake Inversely Associated With Cardiac Events - Medscape, 11/11/04 - "women who consumed the highest levels of ALA — defined as approximately 1.5 g per day — "had a 46% lower risk of sudden cardiac death than women who consumed the least amount of [ALA], which was just over half a gram a day ... 1.5 g equals "about two capfuls of flaxseed oil or a handful of walnuts"
• Omega-3 Fatty Acids: Good For The Heart, And (maybe) Good For The Brain - Science Daily, 11/8/04 - "There is mounting evidence that a diet containing omega-3 fatty acids, already known to help prevent cardiovascular disease, may also prevent depression"
• ConsumerLab.com - Omega-3 Fatty Acids (EPA and DHA) from Fish/Marine Oils review - ConsumerLab.com, 10/6/04 - "None of the products were found to contain detectable levels of mercury ... none of the products contained unsafe levels of PCBs ... none of these supplements contained unsafe levels of dioxins"
• Fish Oil's Breast Cancer Benefits May Vary - WebMD, 9/23/04
• Omega-3 Fatty Acids Get New Health Claim - WebMD, 9/8/04 - "The FDA now says it will allow foods and supplements containing eiscosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 fatty acids to carry a qualified health claim that says eating the product may reduce the risk of heart disease"
• Fish Containing N-3 Fatty Acids Reduce Risk of AF - Medscape, 7/19/04 - "Intake of fatty fish containing N-3 fatty acids reduces the risk of atrial fibrillation (AF), but fish sandwiches or fried fish are not protective"
• Omega-3s appear to protect against prostate cancer - Nutra USA, 6/23/04 - "alpha-linolenic acid (ALA), an omega-6 fat, may raise the risk of advanced prostate cancer ... Men with the highest quintiles of EPA and DHA combined had an 11 per cent lower total prostate cancer risk and advanced prostate cancer risk was 26 per cent lower"
• Fish Oil Prevents Deadly Irregular Heartbeats - WebMD, 4/30/04 - "If these and other trials confirm the anti-arrhythmic properties of these [omega-3 acids], fish oil may become a less toxic and more appetizing alternative to traditional anti-arrhythmic"
• Salmon and Cod Liver Oil Contamination: Key Point - Rely on Pharmaceutical Grade Fish Oil for Your Omega-3 Fatty Acid Needs - Dr. Murray's Natural Facts, 4/21/04 - "To reduce your chances of eating salmon and other fish that is tainted with chemical toxins: ... Eat wild Alaskan salmon as opposed to farm-raised salmon ... Limit your intake of fresh water fish ... Eat smaller, young fish ... The specific product that I recommend is RxOmega-3 Factors from Natural Factors"
• Improving Omega-3 Oils - ffnmag.com, 1/04
• Omega-3 Fatty Acids Vital to a longer, healthier life - Life Extension Foundation, 12/03 - "While an omega-6 to omega-3 ratio of roughly 2:1 is optimal, most Americans consume far more omega-6s than omega-3s, yielding a ratio skewed at least 10:1 in favor of omega-6s. Some estimates put the ratio as high as 40:1 ... Because omega-6s break down into arachidonic acid in the body, and arachidonic acid is converted to highly inflammatory chemicals, a huge increase in the availability of arachidonic acid translates into a huge increase in the potential for inflammatory and autoimmune diseases"
• Get Hooked On Fish - Wellness Insider, 11/25/03 - "Fish is a good source of omega 3s. Elderly individuals who consume fish three times per week can almost cut their risk in half for developing Alzheimer's disease"
• Fish Oil May Help Elite Athletes - WebMD, 11/14/03
• Recent Clinical Studies on Fish Oils - Dr. Murray's Natural Facts, 11/12/03
• Fish And N-3 Fatty Acids Reduce Risk Of Alzheimer’s Disease - Life Extension Foundation, 11/03 - "A new study, from the Rush-Presbyterian, St. Lukes Medical Center, in Chicago, shows that people who consumed at least one serving of fish a week dramatically reduced their risk of Alzheimer’s disease, compared to those who rarely or never ate fish. Dietary intake of omega-3 fatty acids had a similar risk-lowering effect"
• Diet and Exercise - Medscape, 9/9/03 - "Consumption of the omega-3 fatty acids is inversely related to the incidence of atherosclerosis and the risk of sudden death[1,2] and stroke.[3] In high doses, omega-3 fatty acids may reduce blood triglyceride levels, but in dietary amounts, they have little effect on blood lipids. Even in modest amounts, however, omega-3 fatty acids reduce platelet aggregation, impairing thrombogenesis. They may also have antiarrhythmic and plaque-stabilizing properties"
• Inflammation Syndrome a Red-Hot Topic - Natural Foods Merchandiser, 9/03 - "What are some of the key anti-inflammatory supplements? ... At the top of the list are omega-3 fish oils, gamma-linolenic acid (GLA, an omega-6 fat that behaves more like an omega-3) and vitamin E. Several studies have shown that natural vitamin E supplements lower CRP levels by 30 percent to 50 percent"
• The Omega Principle - WashingtonPost.com, 8/19/03 - "Omega-3s, dubbed the "happy" fats in some quarters, are under investigation for treating depression, bipolar disease, attention-deficit hyperactivity disorder, alcoholism, Alzheimer's disease and even the so-called baby blues, or postpartum depression ... there are many profound neurological disorders that are known to be caused by lipid problems ... The brain itself, is, in fact, about 60 percent fat ... while the body can manufacture saturated fat, cholesterol and even some unsaturated fat -- it is incapable of producing two of the fatty acids that are most vital ... there has been an 1,000-fold increase in [consumption of] omega-6 fatty acids ... Flooding brains and bodies with a diet rich in omega-6 fatty acids theoretically could give an unfair advantage to these molecules, allowing them to block omega-3s from getting inside cells" - See Mega Twin EPA at Vitacost or iHerb.
• Eating Fish Lowers Heart Rate - WebMD, 8/12/03 - "This current study involves more than 9,700 men -- all between 50 and 59 years old -- who had no signs of heart disease. Researchers kept track of them from 1991 to 1993, documenting their heart rate, blood pressure, cholesterol, and other heart disease risk factors ... Fish eaters had the lowest heart rates. It's important information because even small reductions in heart rate can make a difference in sudden heart death"
• Beyond the Mediterranean Diet: The Role of Omega-3 Fatty Acids in the Prevention of Coronary Heart Disease - Medscape, 8/1/03 - "The current US consumption of n-3 fatty acids is significantly below recommended levels and new American Heart Association recommendations suggest consuming at least two fish meals per week. Although additional trials are needed, the favorable safety profile and existing clinical trials suggest n-3 fatty acids should be considered a new important adjunct to existing cardiovascular prevention strategies"
• Is Your Salmon Safe? - WebMD, 7/31/03 - "bought 10 salmon filets in grocery stores in Washington, D.C.; Portland, Ore.; and San Francisco. Lab analysis showed "high" PCB levels in seven of the 10 samples"
• Fish Once a Week Cuts Alzheimer's Risk - WebMD, 7/21/03 - "Weekly fish eaters had a 60% lower risk of Alzheimer's than people who rarely or never ate fish ... The beneficial effects of [fatty acids] from fish may be counterbalanced by toxins ... A high antioxidant/low saturated fat diet pattern with a greater amount of fish, chicken, fruits, and vegetables and less red meat and dairy products is likely to lower the risk of AD, as well as that for heart disease and stroke ... Furthermore, B vitamin supplements, containing vitamins B12 and B6 and folic acid, lower plasma total homocysteine levels, possibly decreasing the risk of stroke, heart disease and perhaps Alzheimer's disease"
• New Research Supports Omega-3's Benefits - Natural Foods Merchandiser, 7/03 - "Research keeps piling up to support omega-3 use for a whole host of purposes, from brain food to arrhythmia prevention. In fact, Andrew Weil, M.D., the alternative medicine promoter and guru, recommends omega-3s for no fewer than 20 conditions on his Web site"
• Essential Fatty Acid Beneficial for Women with Personality Disorder - New Hope Natural Media, 7/3/03 - "30 women with moderately severe BPD between the ages of 18 and 40 received 500 mg twice a day of EPA or a similar looking placebo for eight weeks ... Compared with the placebo group, average aggression and depression scores decreased in the EPA treatment group by 44% and 22%, respectively ... a purified EPA product, called ethyl-eicosapentaenoic acid (E-EPA), was used in this study. This product is not yet commercially available" - See Mega Twin EPA at Vitacost or iHerb.
• Pretty in Pink: Atlantic Salmon Under Fire - Natural Foods Merchandiser, 6/03 - "farm-bred salmon—which accounts for 95 percent of Atlantic salmon—is naturally gray. Wild salmon, on the other hand, derives its familiar pink hue from its diet of small crustaceans. So salmon farmers add a dye to their fish feed mix, making it indistinguishable from wild salmon and more appealing to consumers ... Many consumers, however, seek to avoid farm-raised salmon because of concerns about its exposure to antibiotics and PCBs, its higher fat content and its lower omega-3 profile. Research also suggests that canthaxanthin, the most common colorant, may cause an accumulation of pigments in the retina, resulting in impaired vision"
• Fish May Fight Pregnancy Depression Risks - Intelihealth, 5/21/03 - "the more omega-3 fatty acids a woman consumed in seafood during the third trimester, the less likely she was to show signs of major depression at that time and for up to eight months after the birth"
• Fish Oil Benefits Your Eyes - WebMD, 5/8/03 - "Why might fish oil protect eyes from age-related macular degeneration? One component of fish oil is docosahexaenoic acid -- DHA for short. It's one of the omega-3 fatty acids linked to other health benefits. Interestingly, DHA builds up in the eye near light-sensing nerve cells ... Those whose diets had the most fish oil were less likely to have dry eye syndrome than those whose diets had the least fish oil"
• Dietary Omega-3 Fatty Acids May Reduce Risk of AMD - Medscape, 5/6/03 - "Dietary omega-3 fatty acids but not beta-carotene supplementation is associated with a reduced risk of age-related macular degeneration (AMD) ... omega-3 fatty acids may also reduce the risk of dry eye syndrome in women" - See Mega Twin EPA at Vitacost or iHerb.
• Fatty Acids Added To Infant Formula May Cut Later Heart Disease Risks - Doctor's Guide, 5/1/03 - "Several studies have reported lower blood pressure in adults whose diet was supplemented with omega 3 fatty acids, but no published studies have looked at the effect of LCPUFA supplementation on blood pressure in children ... The LCPUFA group had significantly lower mean blood pressure: mean difference -3.0 mm Hg, and mean difference of -3.5 mm Hg diastolic"
• Fortified Formulas Promote Healthy Heart - WebMD, 5/1/03
• Anti-Inflammatory Diet Plus Fish Oil Effective for Rheumatoid Arthritis - New Hope Natural Media, 5/1/03 - "An anti-inflammatory diet and fish oil supplements are both helpful for people with rheumatoid arthritis (RA), but combining them has an even greater effect ... The anti-inflammatory diet improved joint pain, swelling, and overall ability to function by 14%, while the Western diet did not improve symptoms or functioning. Benefits were observed with the addition of fish oil, bringing total improvement to 17% in those eating a Western diet and 37% in those eating the anti-inflammatory diet. Furthermore, the need for anti-inflammatory medications was significantly reduced for those receiving fish oil on both diets, although the group eating the anti-inflammatory diet had greater medication reduction. Medication usage increased for those on the Western diet plus placebo"
• Eating Fish Lowers Heart Disease Risk in Women With Diabetes - WebMD, 3/31/03 - "Women with type 2 diabetes who ate fish once a week were 40% less likely to develop heart disease than those who rarely ate it, and eating fish almost every day was associated with a two-thirds reduction in risk ... It is believed that omega-3 fatty acids abundant in the fat of many fish reduces the risk of heart disease by lowering triglyceride levels, improving blood vessel function, and reducing blood-clot formation"
• Lipid Benefits With Monounsaturated-Fatty-Acids Diet In Healthy People - Doctor's Guide, 3/14/03 - "A moderate supplementation of long-chain n-3 fatty acids in healthy individuals reduces both fasting and post-prandial triacylglycerol concentrations but increases LDL cholesterol, irrespective of the type of diet"
• New Fish Oil Guidelines Endorse Use of Supplements - Clinical Psychiatry News, 1/03 - "the American Heart Association (AHA) has recommended that these patients [documented coronary heart disease] consume about 1g of omega-3 fatty acids per day ... In a major departure, the AHA also said, for the first time, that a recommended nutrient could alternatively be consumed as a supplement"
• The Importance of Pharmaceutical Grade Marine Lipids - Dr. Murray's Newsletter, 1/22/03 - "A diet that is deficient in omega-3 fatty acids, particularly EPA and DHA, results in altered cell membranes. Without a healthy membrane, cells lose their ability to hold water, vital nutrients, and electrolytes. They also lose their ability to communicate with other cells and be controlled by regulating hormones. They simply do not function properly. Cell membrane dysfunction is a critical factor in the development of virtually every chronic disease, especially cancer, diabetes, arthritis, and heart disease ...RxOmega-3 Factors from Natural Factors is an example of this revolutionary new source of long-chain fatty acids"
• Fish Oil Soothes Personality Disorder - WebMD, 1/17/03 - "a new study shows daily fish oil supplementation can significantly reduce their symptoms without the negative side effects associated with other treatments" - See Mega Twin EPA at Vitacost or iHerb.
• BPD Patients Respond To Omega-3 Fatty Acids - Psychiatric News, 1/17/03 - "recruited women for their study through ads placed in Boston newspapers. The ads asked questions such as, "Are you extremely moody? Do you often feel out of control? Are your relationships painful and difficult?" ... In an eight-week study period, 20 of the 30 subjects received daily two 500 mg capsules of an omega-3 fatty acid called E-EPA (ethyl-eicosapentaenoic acid). The remaining 10 subjects received a placebo daily—two capsules containing mineral oil ... They found that while depression and aggression levels had declined in the placebo group from the start of the study to the end, they had dropped even more so in the treatment group ... the omega-3 fatty acid used—E-EPA—"may be a safe and effective form of monotherapy for women with moderately severe borderline personality disorder." ... Perhaps it works, at least in part, through its ability to lead to [cell] membrane stabilization [in the brain] ... the brain is made up of at least 60 percent lipids"
• E-EPA Helpful in Borderline Personality Disorder - Medscape, 1/16/03
• Fatty Acid Effective against Depression - New Hope Natural Media, 1/9/03 - "E-EPA is a chemically modified form of EPA ... the best results were achieved with the smallest amount of E-EPA tested ... The authors of the study speculated that taking too much E-EPA might cause an imbalance between the two major classes of essential fatty acids: the omega-3 class (which includes EPA) and the omega-6 class (which includes linoleic and arachidonic acids ... E-EPA is not widely available at the present time"
• Combating Skin Aging - Life Extension Magazine, 1/03 - "The oral ingestion of fish, flax or perilla oil provides abundant quantities of the omega-3 fatty acids that are so beneficial to the health and appearance of the skin"
• Eicosapentaenoic Acid Enhances Vasodilatation in Coronary Artery Disease Patients - Doctor's Guide, 12/30/02 - "The omega-3 polyunsaturated fatty acid EPA has been shown to improve endothelium-dependent vasodilatation in atherosclerotic arteries"
• Study in 43,000 men touts benefits of even a little fish - USA Today, 12/24/02 - "Men who ate about 3 to 5 ounces of fish one to three times a month were 43% less likely to have a stroke during 12 years of follow-up ... Omega-3 fatty acids, found in most fish, have been shown to lower levels of blood fats linked to cardiovascular disease and to help keep blood from clotting"
• Evidence-based Products - Functional Foods & Nutraceuticals, 12/02 - "3g EPA/d and 3g DHA/d (ROPUFA) increased systemic arterial compliance in 38 dyslipidemic men and women, resulting in reduced pulse pressure and total vascular resistance ... Results showed that ROPUFA increased SAC—36 per cent with EPA and 27 per cent with DHA—compared with placebo"
• Heart Risks Tied Directly To Mercury In Nine-Country Study - Doctor's Guide, 12/2/02 - "High mercury content in some fish may diminish the cardioprotective effects associated with consumption of omega-three fatty acids fish ... While the toenail mercury level was directly associated with risk of myocardial infarction, the fish oil level was inversely associated with this risk"
• Losing Out on Omega-3s? - Dr. Weil, 11/26/02 - "Omega-3s can be destroyed by air, light and heat, which is why the less exposure and processing that fish undergo between being caught and ending up on your plate, the better"
• Fatty acids from fish can ward off heart attacks - Intelihealth, 11/19/02 - "Studies now suggest that components of fish oil, called omega-3 fatty acids, can save the lives of people with heart disease ... The heart association also cited recent research indicating that even people with healthy hearts can benefit from a diet rich in such fish as salmon, bluefish, Arctic char, mackerel and swordfish ... fish can reduce a man's risk of dying from a heart attack by 80% ... omega-3 fatty acids can cut a woman's risk of death by heart attack by 33% ... Fatty fish can contain significant levels of mercury"
• Those With Heart Disease Should Eat Fish - Intelihealth, 11/19/02 - "Various studies of fish or supplements showed a 4 percent to 30 percent reduction in triglycerides, but a doctor's care is advised because large doses can present a risk of bleeding in some people ... People can get the recommended 1 gram per day of DHA and EPA combined by eating a 3- to 4-ounce serving of fatty fish such as salmon, mackerel, herring, trout or white tuna ... Harris said people who take supplements should read the labels and make sure they are getting at least 1 gram of DHA and EPA. With a typical supplement, you need about three capsules to get this amount"
• Supplementation with Fatty Acids Helps Schizophrenic Patients - New Hope Natural Media, 11/14/02 - "E-EPA is a derivative of the dietary fatty acid eicosapentaenoic acid, commonly abbreviated as EPA" - I was wondering what the difference between E-EPA and EPA was.  To bad it doesn't tell you what percentage of EPA that E-EPA is so that you could interpolate it to the following study:
  • Ethyl-Eicosapentaenoate Could Be Effective In Persistent Depression - Doctor's Guide, 10/31/02 - "They say there were beneficial effects on items rating depression, anxiety, sleep, lassitude, libido and suicidality"
• Hold The Mercury - CBS News, 11/5/02 - "89 percent of patients with a fish-heavy diet had blood-mercury levels exceeding that deemed safe by the government"
• Ethyl-Eicosapentaenoate Could Be Effective In Persistent Depression - Doctor's Guide, 10/31/02
• Eating Fish Cuts Risk Of Dementia - Intelihealth, 10/25/02
• Eating Fish Cuts Risk of Dementia - WebMD, 10/24/02 - "Those who ate fish or seafood at least once a week had a significantly lower risk of being diagnosed with dementia during the seven-year study period ... The fatty acids in fish oils provide protection for arteries, which could improve blood flow to the brain. In addition, the fatty acids may reduce inflammation in the brain. They may also have a specific role in brain development and regeneration of nerve cells, the authors suggest"
• Further Evidence Of Fish Consumption Link To Lower Alzheimer Risk - Doctor's Guide, 10/24/02
• Breast Cancer Answers: Strategies Show Promise In Mice - Intelihealth, 10/23/02 - "Another study found that young female mice who ate lots of fish oil had lower breast cancer rates"
• Study Records Elevated Mercury - Intelihealth, 10/19/02 - "A study of Californians who loaded their lunch and dinner menus with fish shows 89 percent wound up with elevated mercury levels in their bodies ... Of that group, 63 people had blood mercury levels more than twice the recommended level and 19 showed blood mercury levels four times the level considered safe. Four people had mercury levels 10 times as high as the government recommends"
• Fish Oil Eases Depression - WebMD, 10/18/02 - "people who added a daily dose of omega-3 fatty acids to their regular antidepressant treatment had significant improvement in symptoms, including anxiety, sleeping problems, sadness, decreased sexual desire, and suicidal tendencies ... Previous studies have suggested that depressed people have lower-than-normal levels of a fatty acid known as EPA (eicosapentaenoic acid), which plays an important role in maintaining normal brain function"
• Fish Oil May Help Relieve Stubborn Depression - Reuters, 10/17/02 - "Daily supplements of an omega-3 fatty acid--found in fish and fish oil--may help alleviate the symptoms of depression in patients who do not respond to standard antidepressant medications, new research findings suggest ... Previous researchers have suggested that the balance of omega-3 fatty acids in the brain may become skewed in people with depression, and earlier studies have shown that fish oil supplements can help alleviate the symptoms of schizophrenia and bipolar disorder, or manic depression"
• More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy for reducing Alzheimer's disease (AD) risk that includes low fat intake and high consumption of fish and antioxidants, along with vitamin E, folic acid, and vitamins B6 and B12 supplements"
• Herbs for ADD? - Dr. Weil, 10/8/02 - "Dr. Newmark does recommend a dietary supplement, omega-3 fatty acids, for all children with ADHD because levels of omega-3s in the plasma and red blood cells of children with ADHD are lower than in normal children"
• Keep The Engine Oiled - Natural Foods Merchandiser, 10/02 - "Remember, that's not 3 g of fish oils, but 3 g of the specific essential fatty acids eicosapentaenoic acid and docosahexaenoic acid" - Something I've been saying all along.  The fish oil doesn't count.  The omega-3 is the sum of the eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acids (DHA).  See Mega Twin EPA at Vitacost or iHerb.
• Can I Stop My Hair from Thinning? - Dr. Weil, 9/13/02 - "Make sure you’re getting enough omega-3 fatty acids ... supplement your diet with GLA (gamma-linolenic acid) in the form of black currant oil or evening primrose oil"
• EPA Useful Add-on Therapy in Schizophrenia - Medscape, 9/9/02 - "After 12 weeks of treatment, the EPA group had significantly greater reduction of Positive and Negative Syndrome Scale total scores and of dyskinesia scores than the placebo group ... We regard these results as remarkable, considering the refractory nature of schizophrenia in the subjects" - See Mega Twin EPA at Vitacost or iHerb.
• Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese, Insulin-Resistant Men - Doctor's Guide, 8/7/02 - "fish oils significantly decreased plasma levels of triglycerides and very low density lipoprotein-apoB, decreased the very low density lipoprotein-apoB secretion rate ... combined treatment with atorvastatin and fish oils decreased very low density lipoprotein-apoB secretion and increased the fractional catabolic rate of apoB in each lipoprotein fraction , as well as the percent conversion of very low density lipoprotein to low density lipoprotein" - See Mega Twin EPA at Vitacost or iHerb.
• Omega-3 May Cut Bipolar Symptoms in Pregnancy - Clinical Psychiatry News, 8/02 - "From studies on animals, scientists now know that omega-3 fatty acids provide for normal brain and central nervous system development. Depriving animals of these compounds is associated with abnormalities in offspring ... Omega-3 fatty acids are thought to dampen signal transduction pathways associated with the pathophysiologic characteristics of bipolar disorder, similar to medications such as lithium and valproate. Omega-3 fatty acids also boost the brain's levels of serotonin ... fish oil supplement capsules carry no danger for pregnant women, according to an FDA spokesperson" - See Mega Twin EPA at Vitacost or iHerb.
• Omega-3 Fatty Acids Improve Systemic Arterial Compliance - Medscape, 7/26/02
• Fishing for a Healthy Heart? - Healthscout, 7/26/02
• Omega-3 Fatty Acids May Prevent Heart Disease By Improving Arterial Elasticity - Intelihealth, 7/25/02 - "The research focused on the effects of two forms of omega-3 fatty acid--eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)--on systemic arterial compliance, a measure of the degree of large artery elasticity. Increased stiffness in the large arteries can lead to systolic hypertension and increased pulse pressure (the difference between diastolic and systolic pressure), both factors that may contribute to increased coronary risk. Thirty-eight middle-aged men and women with elevated plasma total cholesterol consumed an EPA supplement, a DHA supplement, or a placebo during a 7-week dietary intervention. In contrast to the placebo group who showed no change, systemic arterial compliance rose 36% in the EPA group and 27% in the DHA group, while there was a trend toward reduced systolic and pulse pressure. Both omega-3 fatty acid supplement groups experienced significant declines in plasma total triacylglycerol concentrations"
• Arginine and Fish Oil May Help Cancer Patients Undergoing Chemotherapy - Life Extension Magazine, 7/02
• Omega-3 Fish Oils - Fats That Are Good for Everyone - Life Enhancement Magazine, 7/02
• Essential Fatty Acids Improve Thought Process and Behavior in Children with ADHD - New Hope Natural Media Online, 6/13/02 - "ADHD is characterized by impulsive behavior, lack of concentration, restlessness and, in some cases, learning disabilities ... The children were given either a supplement containing 186 mg of eicosapentaenoic acid (EPA), 480 mg of docosahexaenoic acid (DHA), 96 mg of gamma-linolenic acid (GLA), 864 mg of linoleic acid, and 60 IU of vitamin E per day, or a placebo ... the children who took the essential fatty acid supplement had significant improvement in symptom scores related to learning and behavior"
• Sizing up omega-3 - USA Today, 5/1/02 - "The omega-3 picture is muddled by theories about omega-6 fatty acids found in vegetable oils such as corn, safflower, cottonseed and sunflower oils. Simopoulos says people in the USA consume too many of these oils and need to eat a more balanced ratio of omega-6 to omega-3 fatty acids. She doesn't support eating soybean oil, she says, because it's too high in omega-6"
• Eating Away At High Cholesterol Levels - Functional Foods & Nutraceuticals, 4/02
• Fish Oil May Fight Diabetes - WebMD, 4/23/02
• Experiments Strengthen Link Between Fish Oil, Mental Problems - Intelihealth, 4/18/02 - "Infant monkeys fed baby formulas supplemented with omega-3 fatty acids - the ones found in "fish oil" - were stronger and more alert even at less than a week old than monkeys given standard baby formula ... Harvard researchers gave two groups of persons who had recently been hospitalized with depression diets that were high in omega-3 and omega-6, respectively. The results were so dramatic that after three months, the scientists were directed by a research oversight committee to stop the experiment and allow all the subjects to take omega-3"
• Omega-3 Fatty Acid Reduces Pro-Inflammatory Cytokines In Heart Transplant Patients - Doctor's Guide, 4/11/02 - "gave 25 stable heart transplant patients two capsules of omega-3 fatty acid daily - each capsule contained 500 mg of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ... The results suggest that omega-3 fatty acid supplementation increased concentrations of the anti-inflammatory interleukin (IL)-10, from 119 to 268 pg/mL (p=0.00008). There were reductions in systemic levels of pro-inflammatory IL-12, from 473 to 376 pg/mL (p=0.001), and IL-6, from 695 to 569 pg/mL (p<0.0001)" - Why is it important for everyone to keep inflammation in check?  See:
  • Scientists Examine Long-Term Risks And Gains Of Painkillers - Intelihealth, 1/22/02 - "The studies reflect scientists' growing interest in the idea that a common condition, inflammation, may underlie many chronic and debilitating diseases - like Alzheimer's, heart disease, osteoporosis and diabetes - and that drugs that fight inflammation may have a role in preventing or delaying those diseases, or at least slowing them down"
• Omega-3 Fatty Acid Reduces Pro-Inflammatory Cytokines In Heart Transplant Patients - Doctor's Guide, 4/11/02
• Fish Oils Curb Sudden Cardiac Death Risks in Men - Doctor's Guide, 4/11/02
• Fish Oil May Help Your Heart - Intelihealth, 4/10/02
• Fish Oil Fights Heart Disease - WebMD, 4/9/02
• The benefits of fish without the fish?  - CNN, 4/8/02
• Fish Oil Supplements Protect Heart - WebMD, 4/8/02 - "A daily fish oil supplement may help heart attack survivors reduce their risk of sudden death by as much as 42% ... taking one gram daily of omega-3 fatty acids significantly reduced the risk of death in people who had heart attacks ... the researchers found these benefits were not related to common explanations such as lowering cholesterol levels or reducing blood clots ... fatty acids may play a part in regulating the electrical activity of heart muscle cells -- a process responsible for the heart rhythm"
• Fat in Fish May Fight Postpartum Depression - WebMD, 4/8/02 - "Loading up on fatty fish like tuna and salmon while you're pregnant may help ward off postpartum depression as well as give your unborn child a mental boost. New research suggests there's a link between an essential fatty acid known as DHA (docosahexaenoic acid) found in these fish and mental health ... high DHA intake among pregnant women can also reduce pregnancy and birth-related risks like low birth weight, premature birth, and pregnancy-induced high blood pressure"
• Concepts and Controversies in Nutrition, Immune-Enhancing Formulas - Medscape, 3/21/02 - "Immune-enhancing formulas (IEFs), also known as immune-modulating formulas, include arginine, glutamine, nucleic acids, and omega-3 fatty acids"
• Salmon May Help Relieve Depression - WebMD, 3/15/02 - "Patients randomly received either the fish oil capsule or a sugar pill in addition to the antidepressant medication they were taking ... After four weeks, six of 10 patients receiving E-EPA -- but only one of 10 receiving placebo -- had significantly reduced symptoms of depression ... The effect of E-EPA was significant from week two of treatment ... Depressed mood, guilt feelings, worthlessness, and insomnia were all improved" - Note: See Mega Twin EPA at Vitacost or iHerb contains 600 mg of EPA (Eicosapentaenoic Acid).
• Formula With Supplements Boosts Infant-Brain Function - Doctor's Guide, 3/14/02 - "Despite a dietary supply of long-chain polyunsaturated fatty acids (LCPs) from breast milk during the first six weeks of life, infants who were weaned to formula that did not provide long-chain polyunsaturated fatty acids had significantly poorer visual acuity at 17, 26, and 52 weeks of age and significantly poorer steroacuity at 17 weeks of age than did infants who were weaned to LCP-supplemented formula ... She added that better acuity and steroacuity at 17 weeks was correlated with higher concentrations of docosahexaenoic acid in plasma. Better acuity at 52 weeks was correlated with higher concentrations of docosahexaenoic acid in plasma and red blood cells"- See Mega Twin EPA at Vitacost or iHerb.
• Fish Oil Consumption May Prevent Pre-Term Birth - Doctor's Guide, 2/21/02 - "Low consumption of fish oils appears a strong risk factor for pre-term delivery and low birth weight ... A study among 8,729 pregnant Danish women indicates that long chain omega n.3 fatty acids in amounts above 2 g a day may delay spontaneous delivery and prevent recurrence of pre-term delivery"
• Alpha-Linolenic Acid May Help Prevent Heart Disease - Doctor's Guide, 2/1/02
• Omega-3s, the Heart-Healthy Fats --- HealthandAge - HealthandAge, 1/11/02 - "It appears that omega-3s protect the heart in several ways. They may lower the risk of abnormal heart rhythms; reduce the "stickiness" of blood cells, which makes them less likely to form clots and block arteries; and lower high blood triglyceride levels. Most studies have centered on marine sources of omega-3 fatty acids; less is known about the vegetable sources"
• The Wizard is Oz - Life Extension Magazine, 11/01 - "Best-selling author and nutritional guru to the rich and famous, Oz Garcia is singing the praises of the Life Extension Foundation and its products in his newest book, The Healthy High Tech Body, published in September 2001 ... Supplements at the top of Garcia's list of recommendations ... DHA ... NADH ... Alpah Lipoic Acid ... Acetyl-L-Carnitine ... An expanded list of his recommendations includes lycopene, gamma tocopherol, vinpocetine, SAMe, folic acid, carnosine, glutathione, DMAE, Huperzine A, probiotics, MSM, secretagogues, arginine pyroglutamate, IP-6, bioflavonoid formulas and grape skin/seed extracts"
• Fish Oil Supplements Pass Mercury Standards, But Lack Adequate Omega-3 Fatty Acids - Intelihealth, 11/29/01 - "Although none of the products tested positive for mercury (a poison sometimes found in fish), 30% of the products had lower levels of docosahexaenoic acid (DHA) than stated on their labels and 10% had lower levels of eicosapentaenoic acid (EPA). EPA and DHA are the two main fatty acids found in fish oil and are principle sources of omega-3 fatty acids. Omega-3 fatty acids are thought to provide many health benefits, including prevention of heart disease and treatment of pain associated with the early stages of rheumatoid arthritis"
• Omega-3 Fatty Acids Safe for Pregnant Women With Mood Disorders - Clinical Psychiatry News, 11/01 - "Omega-3 fatty acids are well tolerated, nontoxic, and appear to be safe in pregnancy—characteristics that have made them attractive for many patients with mood disorders ... Calculating the dose of commercial preparations can be tricky. Front product panels should be ignored. “You'll see things all over the bottles, like ‘over 1,000 mg of omega-3 fatty acids,’ but they won't necessarily have it,” she said, advising consumers to turn the bottle on its side to add up the milligrams of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)" - I think you'll find that Mega Twin EPA at Vitacost or iHerb has the most bang per capsule. - Ben
• question regarding your new cholesterol-lowering supplement, Policosanol - Life Extension Magazine, 11/01 - "Make sure you are taking at least six Mega EPA fish oil capsules daily, as low dose fish oil may not adequately suppress triglycerides"
• Scientific Review Supports Omega-3 Fatty Acids For The Prevention Of Heart Disease - Intelihealth, 10/11/01
• Ratio of Omega-6 to Omega-3 Fatty Acids - DrMirkin.com, 10/2/01
• Nutritional Supplement Boosts Immune Function In Surgery Patients - Intelihealth, 9/13/01 - "A new study published in the journal Lancet suggests that people who are at high risk of infection after heart surgery may benefit from taking a nutritional supplement containing L-arginine and omega-3 fatty acids"
• Free Fatty Acids May Be Linked to Sudden Cardiac Death in Healthy Men - WebMD, 8/14/01 - "Very high levels of free fatty acids were associated with "2.5 to three times the risk for sudden cardiac death" ... Several factors, including cigarette smoking, fasting, hyperthyroidism, or heart attack, can trigger the release of free fatty acids ... The real risk, says Leaf, who is professor of clinical medicine at Harvard Medical School, comes from omega-6 fatty acids, which are found in foods fried in corn, safflower, or sunflower oils ... By contrast omega-3 fatty acids, which are found in fatty fish and canola oil are actually heart healthy"
• Fats for Life - Life Extension Magazine, 7/01 - "Essential fatty acids (EFAs) cannot be produced within the body and therefore must be provided through the diet. If the diet is lacking in EFAs, saturated fats will take the place of EFAs within cell membranes, reducing membrane fluidity and efficiency, and thereby starting a process of premature aging and disease development. In addition, by taking the right kinds of EFAs in the right proportions, we can maximize the production of beneficial prostaglandins and other chemical messengers, while minimizing production of harmful ones"
• Go Fish! Types High in Fatty Acids May Prevent Prostate Cancer, Herring, Mackerel, and Salmon Recommended - WebMD, 6/1/01 - "Eating fatty fish reduces risk of prostate cancer by about 70%, compared to not eating it, and reduces the risk for death from the disease by about 50%."
• News - Polyunsaturated Fatty Acids Reduce Women's Risk Of Type 2 Diabetes - Doctor's Guide, 5/31/01 - "Trans fatty acids increase the risk of type 2 diabetes in women, while polyunsaturated fatty acids reduce that risk"
• Fish Oil Risks Minimal - Nutrition Science News, 5/01 - "This suggests FO may offer a cardioprotective benefit for postmenopausal women without an increased risk of oxidative stress"
• Letter - Mercury and Fish Oil Supplements - Medscape, 4/13/01 - "The following oils were tested: Twinlab Emulsified Super Max EPA ... Twinlab EPA New & Improved ... Twinlab Omege-3 Concentrate ... In conclusion, it appears that the independent testing and/or the quality control measures claimed by these companies are being done as far as potential mercury contamination is concerned. At the least, the amount of mercury in the fish used is so minimal as to be below the detectable limit by the method used.  In any event, the common brands tested appear to offer no mercury risk. While this is positive health news, it cannot be assumed that every brand is free of mercury"
• PUFAs (omega-3 polyunsaturated fatty acids) for Bone Growth and Repair - Nutrition Science News, 3/01
• Study Reaffirms Value Of Eating Fatty Fish - Intelihealth, 3/4/01 - "We found that eating modest amounts of fatty fish was associated with a 44 percent lower risk in fatal heart attacks"
• Daily Specials: Fatty Fish and Soy Protein - WebMD, 3/2/01 - "In one study of 4,000 men and women with an average age of 72, those who ate one serving per week of fish rich in omega-3 fatty acids had a 44% lower risk of suffering a fatal heart attack, compared to their counterparts who ate fatty fish less frequently. . . In another study of 150 adults with normal blood cholesterol levels, those who consumed 40 g of soy protein per day showed a 4.7% increase in their levels of high-density lipoprotein (HDL), or "good," cholesterol -- without significantly affecting their low-density lipoprotein (LDL), or "bad," cholesterol levels."
• Bone Loss and Fatty Acids - Nutrition Science News, 2/01 - "People often use omega-3 fatty acids to reduce the inflammation associated with arthritis. As it turns out, these fatty acids may actually help prevent bone loss."
• Fatty Fish -- Not Fried -- Reduces Heart Attack Deaths in Older Adults - WebMD, 2/28/01 - "Those who ate at least one serving of fatty fish every week were 35% less likely to die of a heart attack."
• Omega-3s May Help Rheumatoid Arthritis - Nutrition Science News, 2/01 - "Omega-3 fatty acid-rich fish oil supplements may provide modest improvement in rheumatoid arthritis (RA), according to a double-blind, placebo-controlled study conducted at the University of Newcastle in Australia."
• Study: Low Fat Linked To Stroke Risk - Intelihealth, 2/13/01
• Women Who Eat Fish A Few Times Weekly May Cut Stroke Risk, Study Says - Intelihealth, 1/16/01 - "Omega-3 fatty acids, found in most fish, have been shown to lower levels of blood fats linked to cardiovascular disease and to help keep blood from clotting."
• Vegetarians, Essential Fatty Acids and DHA - Nutrition Science News, 10/00
• Fish Oil Slows Lymphoma - Life Extension Magazine, 9/00
• Polyunsaturated Fats and Neurological Disorders - Nutrition Science News, 9/00
• Arthritis and Aging - Life Extension Magazine, 7/00
• The avocado advantage - CNN, 8/15/00
• Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science News, 8/00
• For Reducing Heart Disease Risk, Fish Oil Isn't Snake Oil - WebMD, 8/8/00
• Trans Fats, Omega Fats, Good Fats, Bad Fats: Are You Confused? - WebMD, 7/5/00
• All Fats Are Not Created Equal, Trans Fats, Omega Fats, Good Fats, Bad Fats: Are You Confused? - WebMD, 7/4/00 - "Trans fats act very much like saturated fat in raising cholesterol levels. They also lower good HDL cholesterol, the protective cholesterol. ... Some people say they're actually worse than saturated fats"
• Fish Oil, Vitamin B-12 May Offer Relief During That Time of the Month - WebMD, 6/20/00
• Fat-Soluble Vitamin Absorption Not Threatened by Fat Cutbacks - WebMD, 5/19/00
• Fish May Lower Depression Risk - Intelihealth, 5/16/00
• North Americans need more omega-3 fatty acids - DrMirkin.com, 5/11/00 - "loading our diet with omega-6's from corn, sunflower seeds, safflower seeds, cottonseed, and soybeans. This has changed the ratio of omega-6 to omega-3 fatty acids in out diet to approximately 20-30 to 1 from the traditional range of 1 or 2:1. This high intake of omega-6 fatty acids causes clotting, swelling and constriction of arteries that can cause heart attacks and other diseases. Omega-3 fatty acids can reverse these changes, but most people do not eat nearly enough whole grains, seeds, nuts, leafy greens or deep-water-fish which contain omega-3's. Reduce your intake of omega-6 fatty acids found in most prepared foods and eat lots of the foods that contain omega-3's"
• Immune-Enhancing Therapy Shortens Hospital Stays By Three Days - Doctor's Guide, 12/23/99
• Potential new approach to cystic fibrosis treatment reported - CNN, 10/9/99
• Fish Oil Reduces Atherosclerotic Blockages - Nutrition Science News, 10/99
• Omega-3 Fish Oil for Mood Swings - Life Enhancement Magazine, 7/99
• Researchers Look To Omega-3 Fatty Acid For Manic Depression Treatment - Doctor's Guide, 5/13/99
• Study: Fish oil lowers heart disease death rate - CNN, 5/10/99
• A Smart Start - Nutrition Science News, 3/99
• Essential Fatty Acids Improve Infant IQ - Nutrition Science News, 2/99
• Fat in the diet may affect mental ability - CNN, 9/4/98 - "Americans suffer an imbalance in fatty acids -- too much omega-6, found in vegetable oils, deep fried foods, dressing and margarines, and too little omega-3, found in fish and some vegetables ... Omega-6 is linked to hormonal overload which plays some role in arthritis, asthma and other diseases involving the immune system ... Omega-3, however, has a calming effect on hormone production which may help relieve some immune system diseases as well as mental conditions ranging from depression to attention deficit"
• Study: 'Bad fat' in fast foods clogs arteries faster - CNN, 6/11/98
• Eating Fish May Substantially Reduce Risk Of Sudden Cardiac Death - Doctor's Guide, 1/6/98
• Fish Oil May Offer Better Protection Than Olive Oil Against Heart Disease - Doctor's Guide, 11/12/97
• Protective Effects Of Fish Oil On Heart Depend On Amount Consumed -  Doctor's Guide, 7/8/97

Abstracts:

• A High Omega-3 Fatty Acid Diet Reduces Retinal Lesions in a Murine Model of Macular Degeneration - Am J Pathol. 2009 Jul 16 - "Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Some mice that were given high levels of n-3 fatty acids had lesion reversion" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Omega-3 fatty acid supplementation decreases liver fat content in Polycystic Ovarian Syndrome: a randomised controlled trial employing proton magnetic resonance spectroscopy - J Clin Endocrinol Metab. 2009 Jul 21 - "Omega-3 fatty acid supplementation has a beneficial effect on liver fat content and other cardiovascular risk factors in women with PCOS, including those with hepatic steatosis"
• Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity - Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity"
• Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study - Am J Clin Nutr. 2009 Jun 24 - "We found a dose-dependent inverse association between fish consumption and dementia (PR: 0.81; 95% CI: 0.72, 0.91) that was consistent across all sites except India and a less-consistent, dose-dependent, direct association between meat consumption and prevalence of dementia (PR: 1.19; 95% CI: 1.07, 1.31)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Fish Oil-Based Lipid Emulsions Prevent and Reverse Parenteral Nutrition-Associated Liver Disease: The Boston Experience - JPEN J Parenter Enteral Nutr. 2009 Jul 1 - "Parenteral nutrition-associated liver disease (PNALD) is the most prevalent and most severe complication of long-term parenteral nutrition. Its underlying pathophysiology, however, largely remains to be elucidated. The currently approved parenteral lipid emulsions in the United States contain safflower or soybean oils, both rich in omega-6 polyunsaturated fatty acids (PUFAs). Mounting evidence indicates that the omega-6 PUFAs originating from plant oils in these lipid emulsions may play a role in the onset of liver injury. Fish oil-based lipid emulsions, in contrast, are primarily composed of omega-3 PUFAs, thus providing a promising alternative. The authors review the literature on the role of lipid emulsions in the onset of PNALD and discuss prevention and treatment strategies using a fish oil- based lipid emulsion. They conclude that a fish oil-based emulsion is hepatoprotective in a murine model of PNALD, and it appears to be safe and efficacious for the treatment of this type of liver disease in children" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Fish Oil and Heart Health - J Cardiovasc Pharmacol. 2009 Jun 26 - "Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of cardiac arrhythmias have been identified as possible mechanisms. Moreover, n-3 fatty acids have anti-inflammatory effects, reduce blood pressure, and may also be antiatherogenic. Finally, high doses of n-3 fatty acids can lower elevated serum triglyceride levels. The n-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid) may be considered as a potential risk marker for coronary heart disease mortality, especially sudden cardiac death. The balance of n-6 to n-3 fatty acids is an important determinant in decreasing the risk for coronary heart disease, both in the primary and in the secondary prevention of coronary heart disease. Patients with known coronary heart disease should be recommended to consume n-3 fatty acid supplements at 1 g per day, without raising concerns for interactions with other medications or side effects. On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat"
• Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study - BMC Cancer. 2009 Jun 30;9(1):216 - "Using a multivariate logistic regression model, high intake of fatty fish was associated with a reduced risk for breast cancer in both pre- and postmenopausal women (OR [95% CI] for highest vs. lowest intake quartiles, p for trend: 0.19 [0.08 to 0.45], p < 0.001 for premenopausal women, 0.27 [0.11 to 0.66], p = 0.005 for postmenopausal women). Similarly, reductions in breast cancer risk were observed among postmenopausal subjects who consumed more than 0.101 g of EPA (OR [95% CI]: 0.38 [0.15 to 0.96]) and 0.213 g of DHA (OR [95% CI]: 0.32 [0.13 to 0.82]) from fish per day compared to the reference group who consumed less than 0.014 g of EPA and 0.037 g of DHA per day. Among premenopausal women, there was a significant reduction in breast cancer risk for the highest intake quartiles of omega-3 fatty acids (ORs [95% CI]: 0.46 [0.22 to 0.96]), compared to the reference group who consumed the lowest quartile of intake" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Does eating particular diets alter risk of age-related macular degeneration in users of the age-related eye disease study supplements? - Br J Ophthalmol. 2009 Jun 12 - "Independent of AREDS supplementation, higher intakes of DHA (>/= 64.0 vs. < 26.0 mg/d) (hazard ratio [HR] = 0.73, 95% confidence interval [CI], 0.57, 0.94), EPA (>/= 42.3 vs. < 12.7 mg/d) (HR = 0.74, 95% CI, 0.59, 0.94), and lower dGI (dGI, < 75.2 vs. >/= 81.5) (HR = 0.76, 95% CI, 0.60, 0.96) were associated with lower risk for progression to advanced AMD. Participants consuming lower dGI and higher DHA or EPA had the lowest risk (P for synergistic interaction < 0.001) ... Our findings show an association of consuming a diet rich in DHA with lower progression of early AMD" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells - Am J Clin Nutr. 2009 Jun 10 - "A high EPA+DHA intake changed the expression of 1040 genes, whereas HOSF intake changed the expression of only 298 genes. EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling. CONCLUSION: These results are the first to show that intake of EPA+DHA for 26 wk can alter the gene expression profiles of PBMCs to a more antiinflammatory and antiatherogenic status"
• Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity - Br J Nutr. 2009 May 19:1-5 - "Plasma fatty acid composition was determined by GC. BMI, waist circumference and hip circumference were inversely correlated with n-3 PUFA, EPA and DHA (P < 0.05 for all) in the obese group. Obese individuals had significantly lower plasma concentrations of total n-3 PUFA, compared with healthy-weight individuals (4.53 (sd 1.11) v. 5.25 (sd 1.43) %)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS) - Atherosclerosis. 2009 Apr 5 - "investigated the effects of eicosapentaenoic acid (EPA) on coronary artery disease (CAD) ... impaired glucose metabolism (IGM) and normoglycemic (NG) patients ... Compared to NG patients, IGM patients had a significantly higher CAD hazard ratio (1.71 in the non-EPA group and 1.63 in the EPA group). The treatment with EPA resulted in a 22% decrease in the CAD incidence (P=0.048) in IGM patients and an 18% decrease (P=0.062) in NG patients" - See Mega Twin EPA at Amazon.com.
• Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study - Arch Ophthalmol. 2009 May;127(5):656-65 - "1 serving of fish per week was associated with reduced risk of incident early AMD (relative risk, 0.69 [95% confidence interval, 0.49-0.98]), primarily among participants with less than the median linoleic acid consumption (0.57 [0.36-0.89]). Findings were similar for intake of long-chain omega-3 polyunsaturated fatty acids. One to 2 servings of nuts per week was associated with reduced risk of incident early AMD (relative risk, 0.65 [95% confidence interval, 0.47-0.91])"
• Fat consumption and its association with age-related macular degeneration - Arch Ophthalmol. 2009 May;127(5):674-80 - "Higher trans-unsaturated fat intake was associated with an increased prevalence of late AMD; the odds ratio comparing the highest with the lowest quartile of trans fat was 1.76 (95% confidence interval, 0.92-3.37; P = .02). Higher omega-3 fatty acid intake (highest quartile vs lowest quartile) was inversely associated with early AMD (odds ratio, 0.85; 95% confidence interval, 0.71-1.02; P = .03). Olive oil intake (> or =100 mL/week vs <1 mL/week) was associated with decreased prevalence of late AMD (odds ratio, 0.48; 95% confidence interval, 0.22-1.04; P = .03). No significant associations with AMD were observed for intakes of fish, total fat, butter, or margarine" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis [MESA]) - Am J Cardiol. 2009 May 1;103(9):1238-43 - "Long-chain n-3 PUFA intake was inversely associated with plasma concentrations of interleukin-6 (p = 0.01) and matrix metalloproteinase-3 (p = 0.03) independent of age, body mass index, physical activity, smoking, alcohol consumption, and dietary variables. Nonfried fish consumption was inversely related to C-reactive protein (p = 0.045) and interleukin-6 (p <0.01) ... the results of this study suggest that the dietary intake of long-chain n-3 PUFAs and fish is inversely associated with concentrations of some biomarkers, reflecting lower levels of inflammation and endothelial activation. These results may partially explain the cardioprotective effects of fish consumption" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trials - Am J Clin Nutr. 2009 Apr 29 - "The dose of n-3 LCPUFAs ranged from 0.7 to 5.1 g/d, and the median follow-up was 9 mo. In the pooled analysis, there was a greater reduction in UPE in the n-3 LCPUFA group than in the control group: Cohen's d for all trials was -0.19 (95% CI: -0.34, -0.04; P = 0.01). In a patient with 1 g UPE/d , this corresponds to a reduction of 190 mg/d. Effects on GFR were reported in 12 trials. The decline in GFR was slower in the n-3 LCPUFA group than in the control group, but this effect was not significant (0.11; 95% CI: -0.07, 0.29; P = 0.24)"
• Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet - Br J Nutr. 2009 Apr 28:1-12 - "Wistar rats fed a high-fat diet. Rats were fed diets including lard (19.5 % lard) or n-3 FA (9.1 % lard and 10.4 % Triomar) for 7 weeks. Feed consumption and weight gain were similar, whereas plasma lipid concentrations were lower in the n-3 FA group. Magnetic resonance imaging revealed smaller visceral (mesenteric, perirenal and epididymal) adipose depots in the n-3 FA-fed animals (35, 44 and 32 % reductions, respectively). n-3 FA feeding increased mRNA expression of cytokines as well as chemokines in several adipose depots. Expression of Adipoq and Pparg was enhanced in the mesenteric adipose depots of the n-3 FA-fed rats, and fasting plasma insulin levels were lowered. Expression of the lipogenic enzymes Acaca and Fasn was increased in the visceral adipose depots, whereas Dgat1 was reduced in the perirenal and epididymal depots. Cpt2 mRNA expression was almost doubled in the mesenteric depot and liver. Carcass analyses showed similar body fat (%) in the two feeding groups, indicating that n-3 FA feeding led to redistribution of fat away from the visceral compartment" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals - Eur J Clin Nutr. 2009 Apr 8 - "The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk"
• An oily fish diet increases insulin sensitivity compared to a red meat diet in young iron-deficient women - Br J Nutr. 2009 Feb 12:1-8 - "Insulin levels significantly decreased and insulin sensitivity significantly increased with the oily fish diet. HDL-cholesterol significantly increased with the oily fish diet" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Prevention of insulin resistance by n-3 polyunsaturated fatty acids - Curr Opin Clin Nutr Metab Care. 2009 Mar;12(2):138-46 - "n-3 PUFA supplementation has clinical significance in the prevention and reversal of insulin resistance"
• Protective Effect of Fish Consumption on Colorectal Cancer Risk. Hospital-Based Case-Control Study in Eastern Europe - Ann Nutr Metab. 2009 Jan 26;53(3-4):295-302 - "The adjusted OR showed a significant reduction in CRC already at the moderate fish intake of one or two servings per week (OR = 0.70; 95% CI: 0.51-0.94), but it was even lower at higher fish intake (OR = 0.56; 95% CI: 0.39-0.86)"
• Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells - Br J Pharmacol. 2009 Jan 16 - "Treatment with EPA inhibited I(Na) directly and also indirectly, by down-regulation of Na(v) mRNA expression in prostate cancer cells, thus inhibiting their metastatic potential" - See Mega Twin EPA at Amazon.com.
• Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial - Am J Clin Nutr. 2008 Dec 30 - "Psychological distress (PD) ... To our knowledge, this is the first trial of n-3 supplementation in the treatment of PD and depressive symptoms in middle-aged women. In women with PD without MDE at baseline, the 8-wk changes in PD and depressive scales improved significantly more with E-EPA than with placebo" - See Mega Twin EPA at Amazon.com.
• Fish consumption and risk of major chronic disease in men - Am J Clin Nutr. 2008 Dec;88(6):1618-1625 - "Compared with fish consumption of <1 serving/mo, consumption of 1 serving/wk and of 2-4 servings/wk was associated with a lower risk of total cardiovascular disease of approximately 15%" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial - Menopause. 2008 Nov 20 - "At baseline, the average number of HFs was 2.8 per day. After 8 weeks, HF frequency and score decreased significantly in the E-EPA group compared with the placebo group. There was no difference in the change in HF intensity between groups. Frequency of HFs declined by a mean of 1.58 per day (95% CI, -2.18 to -0.98) in the E-EPA group and by 0.50 per day (95% CI, -1.20 to 0.20) in the placebo group. The odds of being a responder among those taking E-EPA were about three times greater than among those taking placebo (odds ratio, 2.70; 95% CI, 1.03-7.03; P = 0.04). Menopause-Specific Quality of Life scores improved significantly over time in both groups but no significant differences were noted between them"
• A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality - Am J Clin Nutr. 2008 Nov;88(5):1297-303 - "Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish >or=5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05]. A similar association was found between seafood n-3 fatty acid intake and prostate cancer mortality (RR(Q5 versus Q1) = 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Omega-3 as well as caloric restriction prevent the age-related modifications of cholesterol metabolism - Mech Ageing Dev. 2008 Sep 26 - "both caloric restriction and Omega-3 supplemented diets are able to prevent hypercholesterolemia, by regulating HMG-CoAR activation state by controlling ROS production and p38 phosphorylation. Moreover also the age-dependent loss of LDLr membrane exposition is prevented"
• Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis - Am J Clin Nutr. 2008 Oct;88(4):1111-8 - "After adjustment for potential confounders, intakes of long-chain n-3 PUFAs and nonfried (broiled, steamed, baked, or raw) fish were inversely related to subclinical atherosclerosis determined by cCIMT but not by iCIMT, CAC score, or ABI. The multivariate odds ratio comparing the highest to the lowest quartile of dietary exposures in relation to subclinical atherosclerosis determined by cCIMT was 0.69 (95% CI: 0.55, 0.86; P for trend < 0.01) for n-3 PUFA intake; 0.80 (95% CI: 0.64, 1.01; P = 0.054) for nonfried fish consumption; and 0.90 (95% CI: 0.73, 1.11; P = 0.38) for fried fish consumption"
• Increasing dietary fish intake has contributed to decreasing mortality from CHD among the older population in Hong Kong - Public Health Nutr. 2008 Oct 7:1-6 - "The time trend of CHD mortality was inversely related to the trend of fish intake. The frequency of fish intake may have a substantial impact on the population for the prevention of CHD deaths in Hong Kong"
• Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort - Am J Clin Nutr. 2008 Sep;88(3):789-96 - "Higher maternal fish intake and greater duration of breastfeeding were associated with higher child developmental scores at 18 mo [odds ratio: 1.29 (95% CI: 1.20, 1.38) for the highest versus the lowest quintile of fish intake, and 1.28 (1.18, 1.38) for breastfeeding for > or =10 mo compared with breastfeeding for < or =1 mo]. Associations were similar for development at 6 mo. ... Maternal fish intake during pregnancy and the duration of breastfeeding are independently associated with better early child development. Future research and consumption guidelines, incorporating nutritional benefits as well as contaminant risks, should consider the overall effect of prenatal fish consumption on child development"
• Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer - Int J Cancer. 2008 Sep 9 - "Breast cancer risk was not related to any dietary PUFA overall; however, opposite associations were seen according to food sources, suggesting other potential effects than PUFA per se. Breast cancer risk was inversely associated with alpha-linolenic acid (ALA) intake from fruit and vegetables [highest vs. lowest quintile, hazard ratio (HR) 0.74; 95% confidence interval (CI) 0.63, 0.88; p trend < 0.0001], and from vegetable oils (HR 0.83; 95% CI 0.71, 0.97; p trend 0.017). Conversely, breast cancer risk was positively related to ALA intake from nut mixes (p trend 0.004) and processed foods (p trend 0.068), as was total ALA intake among women in the highest quintile of dietary vitamin E (p trend 0.036). A significant interaction was also found between omega-6 and long-chain omega-3 PUFAs, with breast cancer risk inversely related to long-chain omega-3 PUFAs in women belonging to the highest quintile of omega-6 PUFAs (p interaction 0.042). These results emphasize the need to consider food sources, as well as interactions between fatty acids and with antioxidants, when evaluating associations between PUFA intakes and breast cancer risk" - Note:  Alpha-linolenic acid is the vegetable form of omega-3.
• Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals - Atherosclerosis. 2008 Sep 27 - "The combination of n-3 PUFA and plant sterols reduced several inflammatory markers. High sensitivity C-reactive protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha (TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009), leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by 29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in the combination group. CONCLUSION: We have demonstrated, for the first time that dietary intervention with n-3 PUFA and plant sterols reduces systemic inflammation in hyperlipidemic individuals. Furthermore, our results suggest that reducing inflammation provides a potential mechanism by which the combination of n-3 PUFA and plant sterols are cardioprotective" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Fish, omega-3 Polyunsaturated Fatty Acids, and Mortality From Cardiovascular Diseases in a Nationwide Community-Based Cohort of Japanese Men and Women The JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study - J Am Coll Cardiol. 2008 Sep 16;52(12):988-996 - "For mortality from total cardiovascular disease, intakes of fish and omega-3 PUFA were associated with 18% to 19% lower risk ... We found an inverse association between fish and omega-3 PUFA dietary intakes and cardiovascular mortality, especially for heart failure, suggesting a protective effect of fish intake on cardiovascular diseases"
• Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk - Am J Clin Nutr. 2008 Sep;88(3):714-21 - "A high plasma EPA concentration may decrease the risk of dementia, whereas high ratios of n-6 to n-3 fatty acids and of AA to DHA may increase the risk of dementia, especially in depressed older persons. The role of EPA in dementia warrants further research" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration - Am J Clin Nutr. 2008 Aug;88(2):398-406 - "neovascular AMD (NV-AMD) ... Eating oily fish at least once per week compared with less than once per week was associated with a halving of the OR for NV-AMD" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS) - Atherosclerosis. 2008 Jun 19 - "Multiple risk factors besides cholesterol are associated with markedly increased incidence of CAD. High TG with low HDL-C represents a particularly potent risk factor. EPA was effective in reducing the incidence of CAD events for patients with this dyslipidemic pattern, suggesting that EPA may be especially beneficial in patients who with abnormal TG and HDL-C levels" - See Mega Twin EPA at Amazon.com.
• Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study - Eur Heart J. 2008 Jul 18 - "long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46"
• The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of Tumour Necrosis Factor (TNF)-alpha during murine skeletal muscle cell differentiation - Lipids Health Dis. 2008 Jul 18;7(1):24 - "deleterious effects of TNF-alpha on C2C12 myogenesis were completely inhibited by co-treatment with EPA ... EPA has a protective action against the damaging effects of TNF-alpha on C2C12 myogenesis. These findings support further investigations of EPA as a potential therapeutic agent during skeletal muscle regeneration following injury"
• Women's awareness of the importance of long-chain omega-3 polyunsaturated fatty acid consumption during pregnancy: knowledge of risks, benefits and information accessibility - Public Health Nutr. 2008 May 29:1-8 - "Pregnant women lack knowledge of LC n-3 PUFA and health-care services do not provide pregnant women with adequate information on the importance of eating foods high in LC n-3 PUFA during pregnancy"
• Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids - Am J Clin Nutr. 2008 May;87(5):1170-80 - "Test of Variables of Attention; TOVA ... Total TOVA scores increased in the PL-n-3 (mean +/- SD: 3.35 +/- 1.86) and FO (1.72 +/- 1.67) groups but not in the placebo group (-0.42 +/- 2.51) (PL-n-3 > FO > placebo; P < 0.001). A significant correlation between the alterations in FAs and increased TOVA scores mainly occurred in the PL-n-3 group"
• A 22-year Prospective Study of Fish, n-3 Fatty Acid Intake, and Colorectal Cancer Risk in Men - Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1136-43 - "Fish intake was inversely associated with colorectal cancer risk [multivariate relative risk (95% confidence interval) for highest versus lowest category, 0.60 (0.40-0.91); P(trend) = 0.01]. The inverse association was observed for both colon and rectal cancers. Our findings for n-3 fatty acids were similar to those for fish; the multivariate relative risk (95% confidence interval) of total colorectal cancer for the highest versus lowest quartile of n-3 fatty acids was 0.74 (0.57-0.95; P(trend) = 0.01) ... Our results from this long-term prospective study suggest that intakes of fish and long-chain n-3 fatty acids from fish may decrease the risk for colorectal cancer"
• Plasma eicosapentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City Study - Am J Clin Nutr. 2008 May;87(5):1156-62 - "Higher plasma EPA was associated with a lower severity of DS in elderly subjects, especially those taking antidepressants"
• In vivo and in vitro regulation of syndecan 1 in prostate cells by N-3 polyunsaturated fatty acids - J Biol Chem. 2008 Apr 30 - "These findings indicate that syndecan 1 is upregulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma. This mechanism may contribute to the chemopreventive properties of n-3 fatty acids in prostate cancer"
• Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia - Expert Opin Pharmacother. 2008 May;9(7):1237-48 - "Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people with very high triglycerides ... P-OM3 are effective in reducing triglycerides by approximately 30% in this population"
• Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients - World J Gastroenterol. 2008 Apr 21;14(15):2434-2439 - "Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 +/- 4.80 d vs 19.62 +/- 5.59 d, P = 0.19) ... Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response" - See Mega Twin EPA at Amazon.com.
• Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy: Results From a Randomized, Double-Blind, Placebo-Controlled Trial - J Clin Psychiatry. 2008 Mar 18;:e1-e8 - "As compared to the placebo group, subjects in the omega-3 group had significantly lower HAM-D scores at weeks 6 (p = .001) and 8 (p = .019), a significantly higher response rate (62% vs. 27%, p = .03), and a higher remission rate, although the latter did not reach statistical significance (38% vs. 18%" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• New evidence for the cardiovascular benefits of long chain omega-3 Fatty acids - Curr Atheroscler Rep. 2007 Dec;9(6):434-40 - "The role of long chain omega-3 fatty acids (LC n-3 FAs) as cardioprotective agents has become even clearer with the recent publication of the Japan EPA Lipid Intervention Study. This was the largest randomized controlled trial in the field, and it demonstrated that even in a population with one of the highest LC n-3 FA intakes in the world, the addition of eicosapentaenoic acid could reduce cardiac events" - See Mega Twin EPA at Amazon.com.
• Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis - Rheumatology (Oxford). 2008 Mar 24 - "Out of 49 patients 19 (39%) in the cod liver oil group and out of 48 patients 5 (10%) in the placebo group were able to reduce their daily NSAID requirement by >30% ... This study suggests that cod liver oil supplements containing n-3 fatty acids can be used as NSAID-sparing agents in RA patients" - See cod liver oil at Amazon.com and Mega Twin EPA at iHerb
• Omega-3 fatty acid containing diets decrease plasma triglyceride concentrations in mice by reducing endogenous triglyceride synthesis and enhancing the blood clearance of triglyceride-rich particles - Clin Nutr. 2008 Mar 22 - "Levels of hepatic TG and apoB synthesis were 30-50% and 42% lower in mice fed with the fish oil diet compared to the other three diets. In addition, compared to soy oil diet, fish oil feeding significantly increased blood clearance of chylomicron-like lipid emulsions by 21-26%"
• Dietary intake of n-3 polyunsaturated fatty acids is inversely associated with CRP levels, especially among male smokers - Atherosclerosis. 2008 Mar 14 - "Sufficient dietary intake of n-3PUFA may attenuate inflammatory reaction and this effect is more evident among high-risk populations such as male smokers although the small numbers of female ex-smokers and nonsmokers limited statistical power to draw strong conclusions about these groups" - See Mega Twin EPA at Amazon.com.
• Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications - Expert Rev Cardiovasc Ther. 2008 Mar;6(3):391-409 - "Hypertriglyceridemia is a risk factor for atherosclerotic coronary heart disease. Very high triglyceride (TG) levels (>/=500 mg/dl [5.65 mmol/l]) increase the risk of pancreatitis. One therapeutic option to lower TG levels is omega-3 fatty acids, which are derived from the oil of fish and other seafood. The American Heart Association has acknowledged that fish oils may decrease dysrhythmias, decrease sudden death, decrease the rate of atherosclerosis and slightly lower blood pressure, and has recommended fish consumption or fish oil supplementation as a therapeutic strategy to reduce cardiovascular disease. A prescription omega-3-acid ethyl esters (P-OM3) preparation has been available in many European nations for at least a decade, and was approved by the US FDA in 2004 to reduce very high TG levels (>/=500 mg/dl [5.65 mmol/l]). Mechanistically, most evidence suggests that omega-3 fatty acids reduce the synthesis and secretion of very-low-density lipoprotein (VLDL) particles, and increase TG removal from VLDL and chylomicron particles through the upregulation of enzymes, such as lipoprotein lipase. Omega-3 fatty acids differ mechanistically from other lipid-altering drugs, which helps to explain why therapies such as P-OM3 have complementary mechanisms of action and, thus, complementary lipid benefits when administered with statins"
• Effect of Dietary n-3 Polyunsaturated Fatty Acids on the Inducibility of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy - Am J Cardiol. 2008 Mar 15;101(6):758-61 - "Increased consumption of fish and/or fish oil was associated with decreased risk of sudden cardiac death (SCD) ... dietary n-3 fatty acid supplementation decreased the inducibility of VT in patients at risk of SCD. These findings suggest that dietary fish oil can have an antiarrhythmic effect"
• Omega3 Fatty acids for cardioprotection - Mayo Clin Proc. 2008 Mar;83(3):324-32 - "The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed reductions in cardiovascular events of 19% to 45%. These findings suggest that intake of omega-3 fatty acids, whether from dietary sources or fish oil supplements, should be increased, especially in those with or at risk for coronary artery disease. Patients should consume both DHA and EPA. The target DHA and EPA consumption levels are about 1 g/d for those with known coronary artery disease and at least 500 mg/d for those without disease. Patients with hypertriglyceridemia benefit from treatment with 3 to 4 g/d of DHA and EPA, a dosage that lowers triglyceride levels by 20% to 50%. Although 2 meals of oily fish per week can provide 400 to 500 mg/d of DHA and EPA, secondary prevention patients and those with hypertriglyceridemia must use fish oil supplements if they are to reach 1 g/d and 3 to 4 g/d of DHA and EPA, respectively" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.  I take both because the percentage of omega-3 (EPA and DHA) is very low in other supplements.  I don't know what the rest of that oil is but your not saving anything by getting supplements with a low percentage.  Just do the math plus if the rest of the oil is an omega-6 you're not helping the omega-6/omega-3 ratio.
• Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction - Eur J Clin Pharmacol. 2008 Feb 29 - "N-3 PUFA reduced the relative risk of the hospitalization for AF [hazard ratio (HR) 0.19, 95% CI 0.07-0.51] and was associated with a further and complementary reduction in all-cause mortality (HR 0.15, 95% CI 0.05-0.46)"
• Very Low n-3 Long-Chain Polyunsaturated Fatty Acid Status in Austrian Vegetarians and Vegans - Ann Nutr Metab. 2008 Feb 28;52(1):37-47 - "The vegetarian diet, with an average n-6/n-3 ratio of 10/1, promotes biochemical n-3 tissue decline. To ensure physical, mental and neurological health vegetarians have to reduce the n-6/n-3 ratio with an additional intake of direct sources of EPA and DHA, regardless of age and gender" - See Mega Twin EPA at Amazon.com.
• Fish oil in critical illness - Curr Opin Clin Nutr Metab Care. 2008 Mar;11(2):121-7 - "Inclusion of fish oil in nutrition may influence the immune response and clinical outcomes by balancing the negative effects of n-6 fatty acids. Application as a part of enteral immunonutrition in surgical or acute respiratory distress syndrome patients and in lipid emulsions in surgical patients has beneficial effects" - See Mega Twin EPA at Amazon.com.
• Dietary Fish and {omega}-3 Fatty Acid Consumption and Heart Rate Variability in US Adults - Circulation. 2008 Feb 19 - "Habitual tuna/other fish and marine omega-3 consumption are associated with specific HRV components in older adults, particularly indices of vagal activity, baroreceptor responses, and sinoatrial node function"
• Fatty acid status and behavioural symptoms of Attention Deficit Hyperactivity Disorder in adolescents: A case-control study - Nutr J. 2008 Feb 14;7(1):8 - "ADHD adolescents consumed more energy and fat than controls but had similar anthropometry. ADHD children consumed equivalent amounts of omega-3 and omega-6 fatty acids to controls, however they had significantly lower levels of docosahexaenoic acid (DHA, 22:6n-3) and total omega-3 fatty acids, higher omega-6 fatty acids and a lower ratio of n-3:n-6 fatty acids than control subjects. In addition, low omega-3 status correlated with higher scores on several Conners' behavioural scales ... These data suggest that adolescents with ADHD continue to display abnormal essential fatty acid profiles that are often observed in younger children and distinctly different from normal controls of similar age. Further these red blood cell fatty acid differences are not explained by differences in intake. This suggests that there are metabolic differences in fatty acid handling between ADHD adolescents and normal controls. The value of omega-3 supplements to improve fatty acid profiles and possibly behaviours associated with ADHD, need to be examined" - See Jarrow Max DHA at Amazon.com and Mega Twin EPA at Amazon.com.
• Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder - Aust N Z J Psychiatry. 2008 Mar;42(3):192-8 - "EPA + fluoxetine combination was significantly better than fluoxetine or EPA alone from the fourth week of treatment. Fluoxetine and EPA appear to be equally effective in controlling depressive symptoms. Response rates (>/=50% decrease in baseline HDRS) were 50%, 56% and 81% in the fluoxetine, EPA and combination groups, respectively" - See Mega Twin EPA at Amazon.com.
• The effect of dietary fish oil-supplementation to healthy young men on oxidative burst measured by whole blood chemiluminescence - Br J Nutr. 2008 Jan 17;:1-9 - "These results indicate that n-3 LCPUFA may have immuno-stimulating effects"
• n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study - Public Health Nutr. 2008 Jan;11(1):17-29 - "Word Fluency Test (WFT) ... an increase of one standard deviation in dietary long-chain n-3 fatty acids (% of energy intake) and balancing long-chain n-3/n-6 decreased the risk of 6-year cognitive decline in verbal fluency with an odds ratio (95% confidence interval) of 0.79 (0.66-0.95) and 0.81 (0.68-0.96), respectively, among hypertensives. An interaction with hypertensive status was found for dietary long-chain n-3 fatty acids (g day-1) and WFT decline (likelihood ratio test, P = 0.06). This exposure in plasma cholesteryl esters was also protective against WFT decline, particularly among hypertensives (OR = 0.51"
• Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study - Am J Clin Nutr. 2007 Dec;86(6):1670-9 - "A moderate dose of n-3 PUFAs for 2 mo reduced adiposity and atherogenic markers without deterioration of insulin sensitivity in subjects with type 2 diabetes. Some adipose tissue inflammation-related genes were also reduced. These beneficial effects could be linked to morphologic and inflammatory changes in adipose tissue"
• n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study - Public Health Nutr. 2007 Jul 12;:1-13 - "Word Fluency Test (WFT) ... Findings indicated that an increase of one standard deviation in dietary long-chain n-3 fatty acids (% of energy intake) and balancing long-chain n-3/n-6 decreased the risk of 6-year cognitive decline in verbal fluency with an odds ratio (95% confidence interval) of 0.79 (0.66-0.95) and 0.81 (0.68-0.96), respectively, among hypertensives. An interaction with hypertensive status was found for dietary long-chain n-3 fatty acids (g day-1) and WFT decline (likelihood ratio test, P = 0.06). This exposure in plasma cholesteryl esters was also protective against WFT decline, particularly among hypertensives (OR = 0.51"
• High {omega}-6 and Low {omega}-3 Fatty Acids are Associated With Depressive Symptoms and Neuroticism - Psychosom Med. 2007 Nov 8 - "Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism" - See Mega Twinlab Mega Twin EPA at Amazon.com.
• Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study - Am J Clin Nutr. 2007 Nov;86(5):1470-8 - "In the elderly, a diet high in fish and fish products is associated with better cognitive performance in a dose-dependent manner"
• n 3 Fatty acid proportions in plasma and cognitive performance in older adults - Am J Clin Nutr. 2007 Nov;86(5):1479-85 - "In this population, plasma n-3 PUFA proportions were associated with less decline in the speed-related cognitive domains over 3 y"
• Serum phospholipid n 3 long-chain polyunsaturated fatty acids and physical and mental health in a population-based survey of New Zealand adolescents and adults - Am J Clin Nutr. 2007 Nov;86(5):1278-85 - "The results from this population-based survey of New Zealanders suggest a strong and consistent association between eicosapentaenoic acid in serum phospholipids and self-reported physical well-being; the association with mental well-being is less compelling"
• Low Omega-3s in Diet Linked to Higher Anxiety and Depressive Symptoms in Heart Failure Patients - Doctor's Guide, 11/7/07 - "Heart Failure patients who were prone to depressive symptoms ate 15% fewer omega-3 fatty acids and those with anxiety consumed 14% fewer omega-3 fatty acids than heart failure patients without symptoms"
• Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis patients - Br J Nutr. 2007 Nov 1;:1-7 - "Fish oil decreases adrenal activation induced by mental stress and has an insulin sensitizing effect in healthy subjects ... Fish oil supplementation blunted both re-increase in thermogenic response and concomitant increase in plasma epinephrine, but not in plasma norepinephrine, over the last 2 h of the experiment. Fish oil did not alter either whole-body glucose metabolism or substrate oxidation. These data show that in haemodialysis patients, fish oil attenuates adrenal overactivity induced by oral glucose but does not modulate whole-body glucose metabolism and insulin sensitivity"
• A randomised placebo-controlled interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus - Ann Rheum Dis. 2007 Sep 17 - "Low dose dietary supplementation with omega-3 fish oils in SLE not only has a therapeutic effect on disease activity but also improves endothelial function and reduces oxidative stress and may therefore confer cardiovascular benefits"
• Beyond lipids: the role of omega-3 Fatty acids from fish oil in the prevention of coronary heart disease - Curr Atheroscler Rep. 2007 Aug;9(2):145-53 - "Results of the recent JELIS trial in a Japanese population already consuming a high intake of omega-3 fatty acids showed a 19% risk reduction in major coronary events"
• EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls - Atherosclerosis. 2007 Sep 15 - "acute coronary syndromes (ACS) ... Compared with the lowest EPA+DHA group, the odds ratio for an ACS event was 0.58 (95% CI 0.42-0.80), in the intermediate EPA+DHA group and was 0.31 (95% CI 0.14-0.67; p for trend <0.0001) in the highest EPA+DHA group ... Odds for ACS case status increased incrementally as the EPA+DHA content decreased suggesting that low EPA+DHA may be associated with increased risk for ACS"
• Efficacy and tolerability of adding prescription Omega-3 fatty acids 4 g/d to Simvastatin 40 mg/d in hypertriglyceridemic patients: An 8-week, randomized, double-blind, placebo-controlled study - Clin Ther. 2007 Jul;29(7):1354-67 - "This study evaluated the effects on non-HDL-C and other variables of adding prescription omega-3-acid ethyl esters (P-OM3; Lovaza(TM), formerly Omacor(R) [Reliant Pharmaceuticals, Inc., Liberty Corner, New Jersey]) to stable statin therapy in patients with persistent hypertriglyceridemia ... At the end of treatment, the median percent change in non-HDL-C was significantly greater with P-OM3 plus simvastatin compared with placebo plus simvastatin (-9.0% vs -2.2%, respectively; P < 0.001). P-OM3 plus simvastatin was associated with significant reductions in TG (29.5% vs 6.3%) and very-low-density lipoprotein cholesterol (27.5% vs 7.2%), a significant increase in high-density lipoprotein cholesterol (HDL-C) (3.4% vs -1.2%), and a significant reduction in the total cholesterol:HDL-C ratio (9.6% vs 0.7%) (all, P < 0.001 vs placebo) ... In these adult, mainly white patients with persistent hypertriglyceridemia, P-OM3 plus simvastatin and dietary counseling improved non-HDL-C and other lipid and lipoprotein parameters to a greater extent than simvastatin alone"
• Fish Consumption, n-3 Fatty Acids, and Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies - Am J Epidemiol. 2007 Sep 6 - "
• Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients - Eur J Clin Nutr. 2007 Sep 5 - "After 8 weeks follow-up, the large artery elasticity in the fish oil group, compared with its baseline, was significantly improved (C(1): 15.5+/-1.5 vs 12.8+/-3.7 ml mm Hg(-1) x 10), whereas no effects were found in the placebo group (C(1): 13.0+/-3.4 vs 13.4+/-3.8 ml mm Hg(-1) x 10), P=0.027, RM-ANOVA across the two groups"
• Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects - Eur J Clin Nutr. 2007 Aug 15 - "Dietary intervention was associated with significant reductions in TNF-alpha (baseline: 2.2 (s.d. 0.3), post-intervention: 1.5 (s.d. 0.3) pg/ml, P=0.01) and low-density lipoprotein-cholesterol (baseline: 2.5 (s.d. 0.2), post-intervention: 2.3 (s.d. 0.1) mmol/l, P=0.03) and increased adiponectin (baseline: 6.5 (s.d. 0.7), post-intervention: 7.6 (s.d. 0.6) mug/ml, P=0.02). Fasting lipid oxidation was increased (baseline: 0.7 (s.d. 0.1), post-intervention: 0.9 (s.d. 0.1) mg/kg.min, P=0.01), whereas glucose oxidation decreased in both fasting (baseline: 1.6 (s.d. 0.1), post-intervention: 1.3 (s.d. 0.1) mg/kg.min, P=0.02) and hyperinsulinaemic conditions (baseline: 3.6 (s.d. 0.1), post-intervention: 3.3 (s.d. 0.1) mg/kg.min, P=0.04). Insulin sensitivity was not affected by the intervention.  Conclusion: A decreased n-6/n-3 PUFA ratio can be achieved with simple dietary counselling, resulting in multiple, potentially favourable effects on the metabolic and inflammatory profiles"
• Inhibition Of Tumorigenesis in Apc(Min/+) Mice by a Combination of (-)-Epigallocatechin-3-gallate and Fish Oil - J Agric Food Chem. 2007 Aug 16 - "The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in Apc (Min/+) mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups"
• Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients - Nephrology (Carlton). 2007 Aug;12(4):331-6 - "There was a significant increase in EPA (P = 0.01) after treatment, and there was a significant decrease in inflammatory markers (IL-6 and TNF-alpha, P = 0.0001) after supplementation in the tested group ... A dietary regime with fish oil could be used in dialysis patients to slow down the development of atherosclerosis and improve nutritional parameters"
• Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder - Nutr J. 2007 Jul 13;6(1):16 - "Nine children were initially supplemented with 16.2g EPA/DHA concentrates per day. The dosage was adjusted dependent on the ratio of arachidonic acid (AA) to EPA in the isolated plasma phospholipids at four weeks to reach a level normally found in the Japanese population ... A psychiatrist (blind to supplement compliance or dosage modifications) reported significant improvements in behavior (inattention, hyperactivity, oppositional/defiant behavior, and conduct disorder). There was also a significant correlation between the reduction in the AA:EPA ratio and global severity of illness scores"
• Dietary Fatty acids and colorectal cancer: a case-control study - Am J Epidemiol. 2007 Jul 15;166(2):181-95 - "Significant dose-dependent reductions in risk were associated with increased consumption of omega-3 polyunsaturated fatty acids (highest vs. lowest quartile of intake: odds ratio = 0.63, 95% confidence interval: 0.50, 0.80; p < 0.0005 for trend) and of eicosapentaenoic (odds ratio = 0.59, 95% confidence interval: 0.47, 0.75; p < 0.0005 for trend) and docosahexaenoic (odds ratio = 0.63"
• Role of prescription omega-3 Fatty acids in the treatment of hypertriglyceridemia - Pharmacotherapy. 2007 May;27(5):715-28 - "In patients with triglyceride levels above 500 mg/dl, approximately 4 g/day of EPA and DHA reduces triglyceride levels 45% and very low-density lipoprotein cholesterol levels by more than 50%" - See Mega Twin EPA at Herb or Jarrow Max DHA at Amazon.com.
• Effect of omega-3 Fatty Acid supplementation on the arachidonic Acid:eicosapentaenoic Acid ratio - Pharmacotherapy. 2007 May;27(5):633-8 - "Triglyceride levels were not reduced in patients with CAD but were significantly decreased in healthy subjects (by 20% decrease with omega-3 fatty acids 1.5 g/day and by 32% decrease with 3 g/day)"
• Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study - Am J Clin Nutr. 2007 Apr;85(4):1142-7 - "Fish consumers had significantly (P = 0.01) less 5-y subsequent cognitive decline than did nonconsumers. A linear trend was observed for the relation between the intake of EPA+DHA and cognitive decline (P = 0.01). An average difference of approximately 380 mg/d in EPA+DHA intake was associated with a 1.1-point difference in cognitive decline"
• Risk factors for prostate cancer incidence and progression in the health professionals follow-up study - Int J Cancer. 2007 Apr 20 - "In this analysis, only 4 factors had a clear statistically significant association with overall incident prostate cancer: African-American race, positive family history, higher tomato sauce intake (inversely) and alpha-linolenic acid intake. In contrast, for fatal prostate cancer, recent smoking history, taller height, higher BMI, family history, and high intakes of total energy, calcium and alpha-linolenic acid were associated with a statistically significant increased risk. Higher vigorous physical activity level was associated with lower risk ... Only for high calcium intake was there a close correspondence for associations among high-grade cancer, advanced and fatal prostate cancer. Tomato sauce (inversely) and alpha-linolenic acid (positively) intakes were strong predictors of advanced cancer among those with low-grade cancers at diagnosis" - Note: Alpha-linolenic acid (ALA) is the omega-3 fatty acid found from plant sources such as flaxseed.  Omega-3 from fish sources (EPA and DHA)  has been found to be protective.  See:
  • Alpha-linolenic acid - wikipedia.org - "Seed oils are the richest sources of alpha linolenic acid, notably those of rapeseed (canola), soybeans, walnuts, flaxseed, perilla, chia and hemp"
  • Altering Fatty Acid Levels In Diet May Reduce Prostate Cancer Growth Rate - Science Daily, 8/1/06 - "tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids"
  • Go Fish! Types High in Fatty Acids May Prevent Prostate Cancer, Herring, Mackerel, and Salmon Recommended - WebMD, 6/1/01 - "Eating fatty fish reduces risk of prostate cancer by about 70%, compared to not eating it, and reduces the risk for death from the disease by about 50%."
  • Dietary Fatty acids correlate with prostate cancer biopsy grade and volume in jamaican men - J Urol. 2007 Jan;177(1):97-101 - "Omega6 polyunsaturated fatty acids stimulate and Omega3 polyunsaturated fatty acids inhibit prostate cancer growth"
• Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study - Am J Clin Nutr. 2007 Apr;85(4):1103-11 - "Promoting higher intakes of n-3 HUFAs in the diet of hypertensive and dyslipidemic persons may have substantial benefits in reducing their risk of cognitive decline in the area of verbal fluency"
• Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China - Am J Clin Nutr. 2007 Apr;85(4):1090-7 - "Our results support a protective effect of n-3 fatty acids on breast cancer risk" - See Mega Twin EPA at Amazon.com.
• Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults - Psychosom Med. 2007 Mar 30 - "Diets with high n-6:n-3 PUFA ratios may enhance the risk for both depression and inflammatory diseases"
• Omega 3 fatty acids and the brain: review of studies in depression - Asia Pac J Clin Nutr. 2007;16 Suppl:391-7 - "Experimental studies in animals have shown that diets lacking omega 3 PUFA lead to substantial disturbances in neural function, which in most circumstances can be restored by the inclusion of omega 3 PUFA in the diet ... It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties"
• Effect of combination lipid-modifying therapy on the triglyceride lowering effect of fish oil - Am J Med Sci. 2007 Mar;333(3):168-72 - "Fish oil effectively reduces plasma triglyceride levels when administered with concomitant lipid medications"
• Expert opinion: omega-3 fatty acids and bleeding-cause for concern? - Am J Cardiol. 2007 Mar 19;99(6A):44C-46C - "the benefits of triglyceride lowering with omega-3 fatty acids more than outweigh any theoretical risks for increased bleeding"
• n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study - Am J Clin Nutr. 2007 Mar;85(3):803-7 - "The results showed that n-3 fatty acids, especially DHA, are positively associated with bone mineral accrual and, thus, with peak BMD in young men"
• A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain - Pain. 2007 Feb 28 - "The results suggest that omega-3 PUFAs are an attractive adjunctive treatment for joint pain associated with rheumatoid arthritis, inflammatory bowel disease, and dysmenorrhea"
• Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF541): Data from a prospective, randomized, multicenter trial - Crit Care Med. 2007 Jan 25 - "from fish oil (Lipoplus) ... there was a significantly shorter length of hospital stay of approximately 21% ... the administration of Lipoplus in the postoperative period after major abdominal surgery is safe and results in a significantly shorter length of hospital stay"
• Dietary Fatty acids correlate with prostate cancer biopsy grade and volume in jamaican men - J Urol. 2007 Jan;177(1):97-101 - "Omega6 polyunsaturated fatty acids stimulate and Omega3 polyunsaturated fatty acids inhibit prostate cancer growth"
• The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides - J Am Coll Nutr. 2006 Dec;25(6):480-5 - "randomized to either 1000 mg of DHA or 1252 mg of DHA + EPA for eight weeks ... Triglycerides decreased by an average of 21.8% in the DHA group (p < 0.001) and 18.3% in the DHA + EPA group (p < 0.001). The difference between groups was not significant. A greater proportion of subjects in the DHA group achieved triglyceride goal (less than 150 mg/dL) compared to the DHA + EPA group (24.6% versus 10.2%, p < 0.05)"
• {omega}-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial - Arch Neurol. 2006 Oct;63(10):1402-8 - "Administration of omega-3 fatty acid in patients with mild to moderate AD did not delay the rate of cognitive decline according to the MMSE or the cognitive portion of the Alzheimer Disease Assessment Scale. However, positive effects were observed in a small group of patients with very mild AD (MMSE >27 points)"
• Long-term Fatty Fish Consumption and Renal Cell Carcinoma Incidence in Women - JAMA. 2006 Sep 20;296(11):1371-6 - "Compared with no consumption, the multivariate rate ratio (RR) was 0.56 (95% confidence interval [CI], 0.35-0.91) for women eating fatty fish once a week or more. Compared with women consistently reporting no fish consumption, the multivariate RR was 0.26 (95% CI, 0.10-0.67) for those women reporting consistent consumption of fatty fish at baseline"
• Effects of n-3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation - Am J Clin Nutr. 2006 Sep;84(3):540-50 - "Median intake in the intervention group was 17.6 mL fish oil/d (1.8 g 20:5n-3, 3.0 g 22:6n-3, and 5.9 g total n-3 fatty acids). The control group received 17.8 mL corn oil/d (8.5 g 18:2n-6) ... Glucose concentrations (home-monitored) were approximately 1 mmol/L higher in the fish oil group than in the corn oil group at the end of the intervention"
• Effect of n-3 fatty acids on carotid atherosclerosis and haemostasis in patients with combined hyperlipoproteinemia: A double-blind pilot study in primary prevention - Ann Med. 2006 Sep;38(5):367-375 - "Results show a favourable effectiveness of n-3 PUFA on IMT progression and T-IMC that deserves to be confirmed in larger studies. Despite the small sample size, the beneficial effect of n-3 PUFA on platelet function, triglycerides and HDL-C is clearly highlighted"
• n-3 fatty acids and cardiovascular disease - Am J Clin Nutr. 2006 Jun;83(6 Suppl):1477S-1482S - "At doses >3 g/d, EPA plus DHA can improve cardiovascular disease risk factors, including decreasing plasma triacylglycerols, blood pressure, platelet aggregation, and inflammation, while improving vascular reactivity. Mainly on the basis of the results of RCTs, the American Heart Association recommends that everyone eat oily fish twice per week and that those with coronary heart disease eat 1 g/d of EPA plus DHA from oily fish or supplements"
• n-3 fatty acids and the metabolic syndrome - Am J Clin Nutr. 2006 Jun;83(6 Suppl):1499S-1504S - "Increased intakes or supplements of n-3 marine fatty acids may improve defects in insulin signaling and prevent alterations in glucose homeostasis and the further development of type 2 diabetes"
• n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases - Am J Clin Nutr. 2006 Jun;83(6 Suppl):1505S-1519S - "n-3 PUFAs are potentially potent antiinflammatory agents. As such, they may be of therapeutic use in a variety of acute and chronic inflammatory settings. Evidence of their clinical efficacy is reasonably strong in some settings (e.g., in rheumatoid arthritis) but is weak in others (e.g., in inflammatory bowel diseases and asthma)"
• n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits - Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S - "The evidence base supports a dietary recommendation of approximately 500 mg/d of EPA and DHA for cardiovascular disease risk reduction. For treatment of existing cardiovascular disease, 1 g/d is recommended ... A dietary strategy for achieving the 500-mg/d recommendation is to consume 2 fish meals per week (preferably fatty fish). Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d"
• Dietary Fatty acids and the 5-year incidence of age-related maculopathy - Arch Ophthalmol. 2006 Jul;124(7):981-6 - "A 40% reduction of incident early ARM was associated with fish consumption at least once a week (odds ratio [95% confidence interval], 0.58 [0.37-0.90]), whereas fish consumption at least 3 times per week could reduce the incidence of late ARM (odds ratio [95% confidence interval], 0.25 [0.06-1.00]). We found no association between incident ARM and butter, margarine, or nut consumption"
• Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products - Am J Clin Nutr. 2006 Jul;84(1):223-9 - "Greater intake of n-3 PUFAs derived from marine products, as measured with a self-administered questionnaire, was independently related to a lower prevalence of high CRP concentrations in this older Japanese population with a diet rich in marine products. Our findings suggest that even very high intakes of n-3 PUFAs may lower serum CRP concentrations"
• n-3 Fatty acids from fish or fish-oil supplements, but not {alpha}-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review  - Am J Clin Nutr. 2006 Jul;84(1):5-17 - "increased consumption of n-3 FAs from fish or fish-oil supplements, but not of alpha-linolenic acid, reduces the rates of all-cause mortality, cardiac and sudden death, and possibly stroke. The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor"
• Fish Oils Produce Anti-inflammatory Effects and Improve Body Weight in Severe Heart Failure - J Heart Lung Transplant. 2006 Jul;25(7):834-8. Epub 2006 May 24 - "Fish oils decrease TNF-alpha production in heart failure and improve body weight. Fish oil therapy may represent a novel therapeutic approach in late-stage heart failure characterized by cardiac cachexia"
• Omega-3 fatty acids: their beneficial role in cardiovascular health - Can Fam Physician. 2006 Jun;52:734-40 - "There is good evidence in the literature that increasing intake of omega-3 fatty acids improves cardiac outcomes. Physicians need to integrate dietary recommendations for consumption of omega-3 fatty acids into their usual cardiovascular care"
• Omega-3 fatty acids in ADHD and related neurodevelopmental disorders - Int Rev Psychiatry. 2006 Apr;18(2):155-72 - "Dietary supplementation with fish oils (providing EPA and DHA) appears to alleviate ADHD-related symptoms in at least some children, and one study of DCD children also found benefits for academic achievement"
• Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention - Int Rev Psychiatry. 2006 Apr;18(2):107-18 - "Ensuring optimal intakes of omega-3 fatty acids during early development and adulthood shows considerable promise in preventing aggression and hostility"
• Omega-3 treatment of childhood depression: a controlled, double-blind pilot study - Am J Psychiatry. 2006 Jun;163(6):1098-100 - "Analysis of variance showed highly significant effects of omega-3 on symptoms using the CDRS, CDI, and CGI ... Omega-3 fatty acids may have therapeutic benefits in childhood depression"
• Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study - Aliment Pharmacol Ther. 2006 Apr 15;23(8):1143-51 - "non-alcoholic fatty liver disease (NAFLD) ... Supplementation with n-3 PUFA improves biochemical, ultrasonographic and haemodynamic features of liver steatosis. Our study supports the efficacy of n-3 PUFA as a new therapeutic approach in the treatment of NAFLD"
• omega-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - Surg Neurol. 2006 Apr;65(4):326-31 - "were asked to take a total of 1200 mg per day of omega-3 EFAs (eicosapentaenoic acid and decosahexaenoic acid) found in fish oil supplements ... Our results mirror other controlled studies that compared ibuprofen and omega-3 EFAs demonstrating equivalent effect in reducing arthritic pain. omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group"
• The Mediterranean-style diet for the prevention of cardiovascular diseases - Public Health Nutr. 2006 Feb;9(1A):118-23 - "Supplementation with very-long-chain omega-3 fatty acids (about 1 g per day) in patients following a Mediterranean type of diet was shown to decrease the risk of cardiac death by 30% and of sudden cardiac death by 45% in the GISSI trial"
• Omega 3 fatty acids: biological activity and effects on human health - Panminerva Med. 2005 Dec;47(4):245-257 - "As PUFAs are precursors of prostaglandins and leucotriens, which are involved in phlogosis and immune response, a diet rich in fish oil reduces the production of PGE2 involved in many phlogosis events. Moreover, an increase in the eicosapentaenoic acid (EPA) intake leads to a reduction in the production of inflammatory cytokines (interleukin 1, 2, 6 and tumor necrosis factor); so, it is important to use w-3 in chronic inflammatory diseases, as the rheumatoid arthritis. It seems that w-3 could prevent the onset of hormone-dependent tumours (i.e. breast and prostatic cancer); in vitro observations, in fact, have shown that the PG of the series 2, derived from w-6, have a carcinogenic action; instead, the anticancer effect of w-3 could derive from their effect in antagonizing the formation of such PG; it can be useful, therefore, to increase the dietary w-3/w-6 ratio"
• Omega-3 fatty acids improve the diagnosis-related clinical outcome - Crit Care Med. 2006 Apr 13 - "Fish oil had the most favorable effects on survival, infection rates, and length of stay when administered in doses between 0.1 and 0.2 g.kg.day. Lower antibiotic demand by 26% was observed when doses of 0.15-0.2 g.kg.day were infused as compared with doses of <0.05 g.kg.day ... Administration of omega-3 fatty acid may reduce mortality, antibiotic use, and length of hospital stay in different diseases"
• Fish oil in the critically ill: from experimental to clinical data - Curr Opin Clin Nutr Metab Care. 2006 Mar;9(2):140-8 - "N-3 lipids exhibit strong immunologic properties. They offer the possibility to counterbalance the negative effects of conventional n-6 fatty acids"
• The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans - Curr Opin Clin Nutr Metab Care. 2006 Mar;9(2):95-104 - "Clinical trials and experimental studies have shown that omega3 fatty acids have many other potentially important antiatherogenic and antithrombotic effects. Omega-3 fatty acids lower blood pressure and heart rate, improve dyslipidaemia, reduce inflammation, and improve vascular and platelet function. These favourable effects have until recently been primarily attributed to the omega3 fatty acid eicosapentaenoic acid, which is present in large amounts in fish oil. Controlled studies in humans now demonstrate that docosahexaenoic acid, although often present in lower quantities, has equally important anti-arrhythmic, anti-thrombotic and anti-atherogenic effects"
• Long-chain n-3 PUFA: plant v. marine sources - Proc Nutr Soc. 2006 Feb;65(1):42-50 - "An important question is whether dietary intake of the precursor n-3 fatty acid, alpha-linolenic acid (alphaLNA), can provide sufficient amounts of tissue EPA and DHA by conversion through the n-3 PUFA elongation-desaturation pathway ... in adult men conversion to EPA is limited (approximately 8%) and conversion to DHA is extremely low (<0.1%). In women fractional conversion to DHA appears to be greater (9%), which may partly be a result of a lower rate of utilisation of alphaLNA for beta-oxidation in women"
• Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma - Chest. 2006 Jan;129(1):39-49 - "fish oil capsules containing 3.2 g of eicosapentaenoic acid and 2.0 g of docohexaenoic acid ... Our data suggest that fish oil supplementation may represent a potentially beneficial nonpharmacologic intervention for asthmatic subjects with EIB"
• Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese. The Japan Public Health Center-Based (JPHC) Study Cohort I - Circulation. 2006 Jan 9 - "Compared with a modest fish intake of once a week or approximately 20 g/d, a higher intake was associated with substantially reduced risk of coronary heart disease, primarily nonfatal cardiac events, among middle-aged persons"
• Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia?: A preliminary study - Hypertens Res. 2005 Aug;28(8):651-5 - "this preliminary study suggested that eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia"
• Usefulness of omega-3 Fatty acids and the prevention of coronary heart disease - Am J Cardiol. 2005 Dec 1;96(11):1521-9 - "the evidence suggests a role for fish oil (eicosapentaenoic acid, docosahexaenoic acid) or fish in secondary prevention because recent clinical trial data have demonstrated a significant reduction in total mortality, coronary heart disease death, and sudden death. The data on ALA have been limited by studies of smaller sample size and limited quality"
• Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects - Eur J Clin Invest. 2005 Nov;35(11):691-9 - "The mood profile was improved after Omega-3 with increased vigour and reduced anger, anxiety and depression states ... Omega-3 supplementation is associated with an improvement of attentional and physiological functions, particularly those involving complex cortical processing"
• Effect of Very High-fat Diets on Body Weight, Lipoproteins, and Glycemic Status in the Obese - Curr Atheroscler Rep. 2005 Nov;7(6):412-20 - "In contrast, unsaturated fats, and particularly omega-3 fatty acids, have the combined benefits of lowering serum cholesterol and raising high-density lipoprotein, as well as favorable effects on insulin resistance and inflammation; they also lower cardiovascular events in high-risk patients"
• Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence - Diabet Med. 2005 Nov;22(11):1465-75 - "Epidemiological and clinical studies suggest that a high intake of omega-3 PUFA protects against the development of depression. There is also some evidence that a low intake of omega-3 is associated with an increased risk of Type 2 diabetes, but the results are less conclusive ... consumption of omega-3 PUFA reduces the risk of cardiovascular disease and may therefore indirectly decrease depression in Type 2 diabetes, via the reduction of cardiovascular complications"
• Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women - American Journal of Clinical Nutrition, Vol. 82, No. 4, 887-893, October 2005 - "These results suggest that a higher dietary intake of n–3 FAs is associated with a decreased incidence of DES in women"
• Fish Consumption and Cognitive Decline With Age in a Large Community Study - Arch Neurol. 2005;62 - "Compared with a decline rate in score of –0.100 SU/y among persons who consumed fish less than weekly, the rate was 10% slower (–0.090 SU/y) among persons who consumed 1 fish meal per week and 13% slower (–0.088 SU/y) among persons who consumed 2 or more fish meals per week"
• Extending the Cardiovascular Benefits of Omega-3 Fatty Acids - Curr Atheroscler Rep. 2005 Sep;7(5):375-380 - "The cardiovascular benefits of omega (n)-3 fatty acids (FA) become clearer with each passing year ... Studies in women with coronary heart disease now suggest that plaque progression may be slowed by increased intakes of oily fish, even in women with diabetes. The relative importance of the n-6 FA linoleic acid (LA), the short-chain n-3 FA alpha linolenic acid (ALA), and the long-chain n-3 FAs EPA and DHA is becoming clearer. If intakes of the latter are adequate (perhaps over 250 mg/d), then there appears to be little need to consume more ALA or less LA"
• Omega-3 fatty acids decreased irritability of patients with bipolar disorder in an add-on, open label study - Nutr J. 2005 Feb 9;4(1):6 - "Omega-3 Fatty Acid intake helped with the irritability component of patients suffering from bipolar disorder with a significant presenting sign of irritability. Low dose (1 to 2 grams per day), add-on O-3FA may also help with the irritability component of different clinical conditions, such as schizophrenia, borderline personality disorder and other psychiatric conditions with a common presenting sign of irritability"
• Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk? - Curr Atheroscler Rep. 2004 Nov;6(6):447-52 - "The strength of the n-3 story has now led to a proposal that blood levels of EPA plus DHA be considered a new, modifiable, and clinically relevant risk factor for death from CHD"
• Women and Omega-3 Fatty Acids - Obstet Gynecol Surv. 2004 Oct;59(10):722-730 - "because elevated triglyceride levels are associated with cardiovascular disease, especially in women; and because omega-3 FA have powerful effects on triglycerides, women in particular gain from an increased intake of these fatty acids. This is especially important in women receiving hormone therapy, which can increase triglyceride levels. The quality of the omega-3 FA preparation is important. It should have an appropriate antioxidant content not to induce lipid peroxidation, and its content of dioxin and polychlorinated biphenyls (PCBs) should be well below the established safe limit"
• Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease - Am J Clin Nutr. 2004 Sep;80(3):626-32 - "Consumption of fish is associated with a significantly reduced progression of coronary artery atherosclerosis in women with coronary artery disease" - See Mega Twin EPA at Vitacost or iHerb.
• The Clinical Effect of Dietary Supplementation with Omega-3 Fish Oils and/or Copper in Systemic Lupus Erythematosus - J Rheumatol. 2004 Aug;31(8):1551-6 - "There was a significant decline in SLAM-R score from 6.12 to 4.69 (p < 0.05) in those subjects taking fish oil compared to placebo"
• Omega-3 fatty acids - Am Fam Physician. 2004 Jul 1;70(1):133-40 - "Approximately 1 g per day of eicosapentaenoic acid plus docosahexaenoic acid is recommended for cardioprotection. Higher dosages of omega-3 fatty acids are required to reduce elevated triglyceride levels (2 to 4 g per day) and to reduce morning stiffness and the number of tender joints in patients with rheumatoid arthritis (at least 3 g per day). Modest decreases in blood pressure occur with significantly higher dosages of omega-3 fatty acids"
• The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy - Semin Nephrol. 2004 May;24(3):225-43 - "treatment for 2 years with a daily dose of 1.8 g of EPA and 1.2 g of DHA slowed the progression of renal disease in high-risk patients"
• Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes - Int J Clin Pract. 2004 Mar;58(3):297-9 - "The EPA-rich essential fatty acid supplementation led to a marked clinical improvement in her symptoms of chronic fatigue syndrome, starting within 6-8 weeks"
• alpha-Linolenic acid metabolism in men and women: nutritional and biological implications - Curr Opin Clin Nutr Metab Care. 2004 Mar;7(2):137-144 - "Conversion of alpha-linolenic acid to eicosapentaenoic acid is limited in men and further transformation to docosahexaenoic acid is very low" - Note:  Alpha-linolenic acid is the form of omega-3 in flaxseed.  Eicosapentaenoic acid and docosahexaenoic acid are omega-3's in fish oil.
• Omega-3 fatty acids and cardiovascular disease - Curr Opin Clin Nutr Metab Care. 2004 Mar;7(2):131-136 - "Eicosapentaenoic and docosahexaenoic acids, but not alpha-linolenic acid, prevent sudden death and other cardiovascular catastrophies, and have therefore been recently incorporated into the pertinent guidelines of European and American cardiologic societies"
• Benefits of fish oil supplementation for hemodialysis patients - J Am Diet Assoc. 2003 Sep;103(9):1174-7 - "One study indicated that pruritus symptoms improved with fish oil supplementation, but not with supplementation with two other oils. In a study designed to determine whether fish oils could prevent vascular access graft thrombosis, graft patency rates were approximately 76% in the fish oil and approximately 15% in the placebo group (P>.03). In a pilot study, subjects given fish oil required 16% less erythropoietin and experienced a 3.6% increase in serum albumin levels"
• Fish oil prevents the adrenal activation elicited by mental stress in healthy men - Diabetes Metab. 2003 Jun;29(3):289-295 - "In control conditions, mental stress significantly increased heart rate, mean blood pressure, and energy expenditure. It increased plasma epinephrine from 60.9 +/- 6.2 to 89.3 +/- 16.1 pg/ml (p<0.05), plasma cortisol from 291 +/- 32 to 372 +/- 37 micromol/l ... After 3 weeks of a diet supplemented with n-3 fatty acids, the stimulation by mental stress of plasma epinephrine, cortisol, energy expenditure, and plasma non esterified fatty acids concentrations, were all significantly blunted ... Supplementation with n-3 fatty acids inhibits the adrenal activation elicited by a mental stress" - See Mega Twin EPA at Vitacost or iHerb.
• Fish Oil Supplementation Reduces Severity of Exercise-Induced Bronchoconstriction in Elite Athletes - Am J Respir Crit Care Med. 2003 Aug 6 - "These data suggest that dietary fish oil supplementation has a markedly protective effect in suppressing EIB in elite athletes and this may be attributed to their anti-inflammatory properties"
• Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial - Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71 - "In this study, we conducted an 8-week, double-blind, placebo-controlled trial, comparing omega-3 PUFAs (9.6 g/day) with placebo, on the top of the usual treatment, in 28 patients with major depressive disorder. Patients in the omega-3 PUFA group had a significantly decreased score on the 21-item Hamilton Rating Scale for Depression than those in the placebo group" - See Mega Twin EPA at Vitacost or iHerb.
• Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia - Schizophr Res. 2003 Aug 1;62(3):195-204 - "We report the supplementation with a mixture of EPA/DHA (180:120 mg) and antioxidants (vitamin E/C, 400 IU:500 mg) orally morning and evening to schizophrenic patients (N=33) for 4 months ... there was significant reduction in psychopathology based on reduction in individual total scores for brief psychiatric rating scale (BPRS) and positive and negative syndrome scale (PANSS), general psychopathology-PANSS and increase in Henrich's Quality of Life (QOL) Scale" - See Mega Twin EPA at Vitacost or iHerb.
• Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women - Circulation. 2003 Jun 23 - "These results suggest that n-6 fatty acids do not inhibit the antiinflammatory effects of n-3 fatty acids and that the combination of both types of fatty acids is associated with the lowest levels of inflammation. The inhibition of inflammatory cytokines may be one possible mechanism for the observed beneficial effects of these fatty acids on chronic inflammatory-related diseases" - See Mega Twin EPA at Vitacost or iHerb.
• n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease - Am J Clin Nutr. 2003 Jul;78(1):65-71 - "High proportions of n-3 fatty acids in serum lipids are associated with a substantially reduced risk of death"
• Not all fish products prevent heart disease - J Fam Pract. 2003 Jun;52(6):438-41 - "For patients aged >65 years, modest consumption of tuna and other broiled/baked fish is associated with a lower risk of death from ischemic heart disease and fatal arrhythmias. The same is not true of fried fish or fish burgers"
• Omega-3 fatty acids and non-communicable diseases - Chin Med J (Engl). 2003 Mar;116(3):453-8 - "omega-3 PUFA has beneficial effects on increasing heart rate variability, decreasing the risk of stroke, reducing both systolic and diastolic blood pressure, insulin resistance and glucose metabolism. Long chain omega-3 PUFA has anti-cancer and anti-inflammatory activities. omega-3 PUFA has also been reported to have a beneficial effect on attention-deficit/hyperactivity disorder and schizophrenia, and may be effective in managing depression in adults. CONCLUSIONS: Results from epidemiological and dietary intervention studies have shown that omega-3 PUFA represent powerfully a class of bioactive compounds and that dietary intake of omega-3 PUFA plays a critical role in human health in relation to non-communicable diseases" - See Mega Twin EPA at Vitacost or iHerb.
• Effects of eicosapentaenoic acid on platelet activation markers and cell adhesion molecules in hyperlipidemic patients with Type 2 diabetes mellitus - J Diabetes Complications 2003 May;17(3):153-159 - "After treatment with eicosapentaenoic acid (EPA), the levels of CD62P, CD63, annexin V, PDMPs, and MDMPs, sE-selectin, and oxidized LDL antibody were reduced significantly. Triglyceride (TG) and total cholesterol levels were also decreased. Anti-Ox LDL antibodies and MDMPs were correlated positively with platelet CD62P (plt-CD62P) levels. These findings suggest that in hyperlipidemic patients with Type 2 diabetes, EPA may prevent complications caused by oxidized LDL, E-selectin, and activated platelets or monocytes" - See Mega Twin EPA at Vitacost or iHerb.
• n -3 Fatty acids plus oleic acid and vitamin supplemented milk consumption reduces total and LDL cholesterol, homocysteine and levels of endothelial adhesion molecules in healthy humans - Clin Nutr 2003 Apr;22(2):175-82 - "The purpose of this study was to evaluate the effect of a commercially available skimmed milk supplemented with n -3 PUFA, oleic acid, and vitamins E, B(6), and folic acid (Puleva Omega3((R))) on risk factors for cardiovascular disease ... Thirty volunteers were given 500 ml/day of semi-skimmed milk for 4 weeks and then 500 ml/day of the n -3 enriched milk for 8 further weeks ... The consumption of n -3 enriched milk produced a significant decrease in plasma concentration of total and LDL cholesterol accompanied by a reduction in plasma levels of homocysteine" - 500 ml is 2.1 cups.  Oleic acid is an omega-9.
• Essential fatty acids and the brain - Can J Psychiatry 2003 Apr;48(3):195-203 - "The ratio of membrane omega-3 to omega-6 PUFAs can be modulated by dietary intake. This ratio influences neurotransmission and prostaglandin formation, processes that are vital in the maintenance of normal brain function"
• Cognitive decline and fatty acid composition of erythrocyte membranes - Am. J. of Clinical Nutr., 4/03 - "studied the relation between erythrocyte membrane fatty acid composition and cognitive decline in free-living volunteers ... Higher proportions of both stearic acid (saturated, 18:0) and total n-6 polyunsaturated fatty acids were associated with greater risk of cognitive decline ... Conversely, a higher proportion of total n-3 fatty acids was associated with a lower risk of cognitive decline"
• Randomized controlled trial of the effect of n–3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity1 - AJCN, 2/03 - "randomly assigned to receive either fish oil capsules (4 g/d, consisting of 45% eicosapentaenoic acid and 39% docosahexaenoic acid as ethyl esters) or matching placebo ... Fish oil supplementation significantly (P < 0.05) lowered plasma concentrations of triacylglycerols (-18%) and VLDL apo B (-20%) and the hepatic secretion of VLDL apo B (-29%) compared with placebo" - Doing the math, 45% of 4 grams equals 1,800 mg of EPA,  39% of 4 grams equals 1,560 mg of DHA.  Three Mega Twin EPA (at Vitacost or iHerb) plus three Jarrow Max DHA at Amazon.com (the two strongest formulas I know) would be 2,100 mg EPA and 1,570 mg DHA.
• Omega-3 Fatty Acid Treatment of Women With Borderline Personality Disorder: A Double-Blind, Placebo-Controlled Pilot Study -  American Journal of Psychiatry, 1/03 - "The results of this study suggest that E-EPA may be a safe and effective form of monotherapy for women with moderately severe borderline personality disorder"
• Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease - Hypertens Res 2002 Nov;25(6):823-9
• Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial - Arch Gen Psychiatry. 1999 May;56(5):407-12 - "A Kaplan-Meier survival analysis of the cohort found that the omega3 fatty acid patient group had a significantly longer period of remission than the placebo group (P = .002; Mantel-Cox). In addition, for nearly every other outcome measure, the omega3 fatty acid group performed better than the placebo group."

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