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Home > Health Conditions > Leukemia


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  • Involvement of Sphingolipid Metabolism Enzymes in Resveratrol-Mediated Cytotoxicity in Philadelphia-Positive Acute Lymphoblastic Leukemia - Nutr Cancer 2021 Nov 22 - "Targeting the key enzymes of sphingolipid metabolism including serine palmitoyltransferase (SPT), sphingosine kinase (SK) and glucosylceramide synthase (GCS) has a therapeutic importance. However, sphingolipid metabolism-mediated anti-leukemic actions of resveratrol in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) remain unknown ... Resveratrol inhibited proliferation and triggered apoptosis via PARP activation and externalization of phosphatidylserine (PS). Resveratrol increased the expression of SPT whereas it downregulated SK and GCS. Resveratrol's combinations with SKI II and PDMP intensified its anti-leukemic activity by increasing the relocalization of PS while its combination with myriocin suppressed apoptosis. Therefore, resveratrol inhibited cell proliferation and induced apoptosis through modulating SK, GCS and SPT expression, which may be considered as novel biomarkers of resveratrol-induced cytotoxicity in Ph + ALL" - See resveratrol products at Amazon.com.
  • Avocado discovery may point to leukemia treatment - Science Daily, 4/29/21 - "Earlier, his lab looked at avocatin B, a fat molecule found only in avocados, for potential use in preventing diabetes and managing obesity. Now he's eager to see it used in leukemia patients"
  • Vitamin D levels in patients with non-Hodgkin lymphoma/diffuse large B-cell lymphoma, chronic lymphocytic leukemia and multiple myeloma - J Int Med Res 2020 Jul - "We measured serum levels of vitamin D by ELISA in 103 patients prior to initiation of treatment, of whom 37 were diagnosed with MM, 32 with CLL and 34 with NHL-DLBCL ... Suboptimal serum vitamin D levels (<30 ng/mL) were observed in all 103 patients. In 14 patients, serum vitamin D levels were between 20 and 30 ng/mL, while all other patients had vitamin D deficiency (<20 ng/mL). Severe vitamin D deficiency (<10 ng/mL) was observed in 32.3% of NHL-DLBCL patients, 28.1% of CLL patients and 81% of MM patients" - See vitamin D at Amazon.com and vitamin D at iHerb.
  • The Role of the Curcumin for Inducing Apoptosis in Acute Lymphoblastic Leukemia Cells: A Systematic Review - Nutr Cancer 2020 Jul 13 - "Acute lymphoblastic leukemia (ALL) is a hematological malignancy of lymphoid progenitor cells associated with excessive proliferation of lymphocytes. Curcumin, a polyphenolic compound, is known to possess anticancer activity ... According to six articles that were selected, curcumin could enhance the antitumor activity of chemotherapy drugs such as L-asparaginase. Curcumin induces apoptosis in Pre B- ALL and T- ALL cells by decreased NF-kB levels, increased p53 levels, PARP-1 cleavage. Also, the induction of growth-arrest and apoptosis in association with the blockade of constitutively active JAK-STAT pathway suggests this be a mechanism by curcumin. Curcumin could be used for the treatment of cancer like ALL" - See curcumin at Amazon.com and iHerb.
  • Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways - Cancer Lett. 2018 Dec 11;443:167-178 - "MLL-rearranged leukemia is an aggressive malignancy associated with poor outcome, which is refractory to conventional treatment. Melatonin has been proven to exert anti-tumor activity ... Collectively, these results suggest that melatonin inhibits MLL-rearranged leukemia through suppressing the RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. Our findings provide new insights into the role of melatonin for MLL-r leukemia treatment" - See melatonin at Amazon.com.
  • L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells - Nutr Cancer. 2018 Apr 26:1-13 - "Arsenic trioxide (As2O3) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind As2O3 toxicity ... Cotreatment of antioxidant vitamins with As2O3 resulted in a significant reversal of oxidative stress markers. Our findings substantiate the effect of antioxidant vitamins in protecting the hepatocytes from oxidative stress which may be attributed through Nrf2 (Nuclear factor erythroid 2-related factor 2) mediated upregulation of Bcl2 (B-cell lymphoma 2) expression" - See vitamin C products at Amazon.com and vitamin E products at Amazon.com.
  • Vitamin C regulates stem cell function, curbs leukemia development, scientists discover - Science Daily, 8/21/17 - "These findings have implications for older patients with a common precancerous condition known as clonal hematopoiesis. This condition puts patients at a higher risk of developing leukemia and other diseases, but it is not well understood why certain patients with the condition develop leukemia and others do not ... Our results suggest patients with clonal hematopoiesis and a Tet2 mutation should be particularly careful to get 100 percent of their daily vitamin C requirement ... Because these patients only have one good copy of Tet2 left, they need to maximize the residual Tet2 tumor-suppressor activity to protect themselves from cancer" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
  • Vitamin C may encourage blood cancer stem cells to die - Science Daily, 8/17/17 - "Vitamin C may "tell" faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers ... We're excited by the prospect that high-dose vitamin C might become a safe treatment for blood diseases caused by TET2-deficient leukemia stem cells, most likely in combination with other targeted therapies ... Changes in the genetic code (mutations) that reduce TET2 function are found in 10 percent of patients with acute myeloid leukemia (AML), 30 percent of those with a form of pre-leukemia called myelodysplastic syndrome, and in nearly 50 percent of patients with chronic myelomonocytic leukemia ... vitamin C did the same thing as restoring TET2 function genetically. By promoting DNA demethylation, high-dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
  • Higher risk of leukemia linked to low sunlight, vitamin D - Science Daily, 1/6/16 - "These results suggest that much of the burden of leukemia worldwide is due to the epidemic of vitamin D deficiency we are experiencing in winter in populations distant from the equator" - See vitamin D at Amazon.com.
  • Could Common Diabetes Drugs Help Fight Leukemia? - WebMD, 9/2/15 - "patients with chronic myeloid leukemia (CML) who received a glitazone -- a class of drug for type 2 diabetes -- along with the standard CML drug imatinib remained disease-free for up to nearly five years ... Actos and Avandia are two well-known glitazone"
  • Chemopreventive effects of dietary eicosapentaenoic acid supplementation in an experimental myeloid leukemia - Cancer Prev Res (Phila). 2015 Aug 19 - "Supplemented mice exhibited a decrease in leukemia burden and a decrease in the LSC colony-forming unit (LSC-CFU). The decrease in LSCs was confirmed through serial transplantation assays in all disease models. The results support a chemopreventive role for EPA in myeloid leukemia, which is dependent on the ability to efficiently convert EPA to endogenous cyclooxygenase-derived prostanoids, including Δ12-PGJ3" - See fish oil supplements at Amazon.com.
  • Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells - Phytother Res. 2015 Apr 8 - "Although imatinib mesylate (IM) in the treatment of chronic myelogenous leukemia (CML) remains the best example of successful targeted therapy, majority of patients with CML suffer its toxicity profile and develop chemoresistance to existing therapeutic agents ... Korean red ginseng extract broadly suppressed the proliferation of five different cell lines, but KRGE was found to be the most potent inducer of apoptosis against KBM-5 cells ... The combination treatment of KRGE and IM caused pronounced suppression of p38 and signal transducer and activator of transcription 5 phosphorylation and induced phosphorylation of p53 compared with the individual treatment. Our results demonstrate that KRGE can enhance the anticancer activity of IM and may have a substantial potential in the treatment of CML" - See ginseng at Amazon.com.
  • Multi-target effects of Quercetin in Leukemia - Cancer Prev Res (Phila). 2014 Oct 7 - "The antitumor activity of quercetin both in vitro and in vivo revealed in this study, point to quercetin as an attractive antitumor agent for hematological malignancies" - See quercetin at Amazon.com.
  • The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity - Evid Based Complement Alternat Med. 2013;2013:407839 - "Arsenic trioxide (As2O3) shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Unfortunately, limiting the application of this effective agent to APL patients is severe cardiotoxicity. Resveratrol, the natural food-derived polyphenolic compound, is well known for its antioxidant properties and protects the cardiovascular system. But the potential role of resveratrol against As2O3 in heart via nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) is unclear ... Our findings suggest coadministration with resveratrol, and As2O3 might provide a novel therapeutic strategy for APL" - See resveratrol products at Amazon.com.
  • Dietary Intake of Vegetables, Fruits, and Meats/Beans as Potential Risk Factors of Acute Myeloid Leukemia: A Texas Case-Control Study - Nutr Cancer. 2013 Oct 29 - "This study was conducted at the University of Texas MD Anderson Cancer Center to evaluate associations between consumption of vegetables, fruits, and meats with AML risk among Texas residents ... Overall, AML risk was significantly decreased among those who consumed the most dark green vegetables, seafood, and nuts/seeds; and it was significantly increased among greatest consumers of red meat. Among men, AML risk was lowest among those whose consumption was in the highest quartile for fruits [odds ratio (OR) = 0.25, 95% confidence interval (CI) = 0.10-0.69], poultry (OR = 0.28, 95%CI = 0.10-0.78), and seafood (OR = 0.39, 95%CI = 0.16-0.96) compared to those in the lowest. Among women, risk was lowest among those whose consumption was in the highest quartile of dark-green vegetables (OR = 0.28, 95%CI = 0.12-.68), orange vegetables (OR = 0.40, 95%CI = 0.17-.96) and nuts/beans (OR = 0.26, 95%CI = 0.11-0.60)"
  • Zinc supplementation in children and adolescents with acute leukemia - Eur J Clin Nutr. 2013 Aug 21 - "The aim of this study was to evaluate the effects of oral zinc supplementation on weight gain and infectious episodes in children and adolescents with acute leukemia ... study included 38 patients ... it has become evident that supplementary zinc exerts a positive effect on nutritional status as positive weight gain. Moreover, the number of infection episodes was significantly reduced, possibly because of the immune stimuli ... zinc supplementation can prevent some of the chemotherapy adverse effects in children with leukemia, improving their quality of life" - See Jarrow Zinc Balance at Amazon.com.
  • Vegetable compound could become ingredient to treating leukemia - Science Daily, 12/12/12 - "A concentrated form of a compound called sulforaphane found in broccoli and other cruciferous vegetables has been shown to reduce the number of acute lymphoblastic leukemia cells in the lab setting ... performed this work while a clinical fellow in the Texas Children's Cancer and Hematology Centers, incubated human-derived leukemic cell lines and primary lymphoblasts from pediatric patients with the compound. The cancer cells died while the healthy cells obtained from healthy donors were unaffected. Studies tested in pre-clinical mouse models showed similar results" - See sulforaphane at Amazon.com.
  • Neoplasm Prevention and Immuno-Enhancement Mediated by Daily Consumption of a Proprietary Extract from North American Ginseng by Elderly Mice of a Cancer-Prone Strain - Phytother Res. 2012 Nov 7 - "We have previously shown in a leukemia-induced tumor model (mouse) that a proprietary extract (CVT-E002), of North American ginseng, administered in the diet, significantly increased the absolute numbers of NK cells, significantly decreased leukemia cells and significantly increased the life span of CVT-E002-fed leukemic mice. In the present study, we assessed the efficacy of this extract to inhibit the spontaneous development of tumors in elderly mice of the cancer-prone C3H strain. Dietary CVT-E002 was fed for approximately a year beginning when mice were almost 2 years of age. Control mice, consuming the same chow without CVT-E002, all developed assorted, palpable tumors between 22 and 33 months, while all mice consuming CVT-E002 remained alive and tumor-free until they were purposely euthanized as healthy animals. The absolute numbers of NK cells at euthanasia, in CVT-E002-consuming mice, were significantly elevated in both the spleen and bone marrow. Given these profoundly positive results and the fact that CVT-E002 already exists in the marketplace under the label Cold-fX®, the potential for cancer prevention in humans becomes apparent" - See Cold FX, 300mg 168 Capsules.
  • Possible cure for leukemia found in fish oil - Science Daily, 12/22/11 - "The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice ... The compound is produced from EPA -- Eicosapentaenoic Acid -- an Omega-3 fatty acid found in fish and in fish oil ... During the experiments, the researchers injected each mouse with about 600 nanograms of D12-PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse ... The researchers focused on D12-PGJ3 because it killed the leukemia stem cells, but had the least number of side effects" - See Mega Twin EPA at Amazon.com.
  • Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells - Cancer Lett. 2011 Jun 15 - "Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL" - See resveratrol products at Amazon.com.
  • Resveratrol Triggers Apoptosis Through Regulating Ceramide Metabolizing Genes in Human K562 Chronic Myeloid Leukemia Cells - Nutr Cancer. 2011 Apr 14:1 - "There were synergistic cytotoxic and apoptotic effects of resveratrol with coadministration of C8:ceramide, PDMP, and SK-1 inhibitor. Interestingly, there were also significant increases in expression levels of LASS genes and decreases in expression levels of GCS and SK-1 in K562 cells in response to resveratrol. Our data, in total, showed for the first time that resveratrol might kill CML cells through increasing intracellular generation and accumulation of apoptotic ceramides" - See resveratrol products at Amazon.com.
  • Insufficient vitamin D levels in chronic lymphocytic leukemia patients linked to cancer progression and death - Science Daily, 11/3/10 - "patients with insufficient levels of vitamin D when their leukemia was diagnosed progressed much faster and were about twice as likely to die as were patients with adequate levels of vitamin D ... They also found solid trends: increasing vitamin D levels across patients matched longer survival times and decreasing levels matched shortening intervals between diagnosis and cancer progression ... Other studies have suggested that low vitamin D levels at diagnosis may be associated with poorer outcomes in colorectal, breast, melanoma and lung cancers, as well as lymphoma ... Vitamin D insufficiency, in general, is widespread" - See vitamin D at Amazon.com.
  • Green tea extract appears to keep cancer in check in majority of CLL patients - Science Daily, 6/4/10 - "the blood lymphocyte (leukemia cell) count was reduced in one-third of participants, and that the majority of patients who entered the study with enlarged lymph nodes due to involvement by CLL saw a 50 percent or greater reduction in their lymph node size ... 31 percent of patients had a 20 percent or greater sustained reduction in blood leukemia count, and 69 percent of patients with enlarged lymph nodes saw a reduction of node size of 50 percent or greater" - It says 6/4/10 but it just showed up.  I think it's a misprint.  See green tea extract at Amazon.com.
  • Exercise Benefits Leukemia Patients - Science Daily, 8/3/09
  • Green tea may protect against blood cell cancer - Nutra USA, 7/31/09 - "Drinking five or more cups of green tea per day may reduce the risk of blood- and lymph-based cancers by about 50 per cent ... Compared to people who drank only one cup per day, five cups of green tea a day were associated with a 42 per cent reduction in hematologic malignancies, and a 48 per cent risk reduction in lymphoid neoplasms" - [Abstract] - See green tea extract at Amazon.com.
  • Green Tea Consumption and Hematologic Malignancies in Japan: The Ohsaki Study - Am J Epidemiol. 2009 Jul 29 - "Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). The corresponding risk estimate was 0.52 (95% confidence interval: 0.31, 0.87) for lymphoid neoplasms and 0.76 (95% confidence interval: 0.32, 1.78) for myeloid neoplasms" - See green tea extract at Amazon.com.
  • Green Tea Extract Shows Promise In Leukemia Trials - Science Daily, 5/26/09 - "We found not only that patients tolerated the green tea extract at very high doses, but that many of them saw regression to some degree of their chronic lymphocytic leukemia ... majority of individuals who entered the study with enlarged lymph nodes saw a 50 percent or greater decline in their lymph node size" - See green tea extract at Amazon.com.
  • Grape-seed Extract Kills Laboratory Leukemia Cells, Proving Value Of Natural Compounds - Science Daily, 12/31/08 - "An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract ... They also discovered that the extract does not affect normal cells, although they don't know why" - See grape seed extract at Amazon.com.
  • Vitamin D3 induces autophagy of human myeloid leukemia cells - J Biol Chem. 2008 Jul 15 - "These findings extend our understanding of the action of vitamin D3 in antineoplastic effects and the role of Beclin1 in regulating multiple cellular cascades, and suggest a potentially promising strategy with a significantly better antileukemia effect" - See vitamin D at Amazon.com.
  • Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro - Cancer Lett. 2008 Feb 29 - "Aqueous mistletoe extracts (MT) ... Both MTs significantly improved survival (up to 55.4 days) at all tested concentrations in contrast to controls (34.6 days) without side effects"
  • Antioxidant Found In Many Foods And Red Wine Is Potent And Selective Killer Of Leukemia Cells - Science Daily, 4/23/07 - "anthocyanidins, a group of naturally occurring compounds widely available in fruits and vegetables as well as red wine, have chemopreventive properties ... the most common type of a naturally modified anthocyanidin, known as cyanidin-3-rutinoside, or C-3-R ... C-3-R caused about 50 percent of a human leukemia cell line known as HL-60 to undergo programmed cell death"
  • Mayo Clinic Reports Some Chronic Leukemia Patients May Improve By Taking An Extract Of Green Tea - Science Daily, 12/13/05 - "In the small case study, the researchers report on four patients who appeared to have an improvement in the clinical state of their disease after starting over-the-counter products containing epigallocatechin gallate (EGCG), an extract of green tea. Three of the four patients met the standard criteria used to define a response treatment for clinical trials. These same investigators had previously shown that EGCG kills leukemia cells from patients with CLL in the test tube" - See iHerb or Vitacosticon green tea products.
  • Leukemia and Lymphoma (Hodgkin's and Non-Hodgkin's Disease) - Life Extension Foundation
  • Tea Ingredient Fights Leukemia - WebMD, 4/4/05 - "Tea extracts shut down leukemia cells but help normal cells fight cancer and infection" - See iHerb or Vitacosticon green tea products.
  • Chemical in Feverfew Plant May Fight Leukemia - WebMD, 2/25/05
  • Can A Daisy Kill Leukemia? - mercola.com, 2/24/05
  • Child's leukaemia risk lower if mother eats well - Nutra USA, 9/28/04
  • Many Children With ALL Deficient in Antioxidant Vitamins - Medscape, 6/7/04
  • VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia - Blood. 2004 Aug 1;104(3):788-94
  • Green tea action on leukaemia - Nutra USA, 4/1/04
  • Aspirin Reduces Risk of Leukemia by Half - Physician's Weekly, 8/4/03 - "women who took aspirin two or more times per week were 55% less likely to develop leukemia than those who never used aspirin" - See aspirin at Amazon.com.
  • Aspirin May Lower Adult Leukemia Risk - WebMD, 6/17/03
  • Pregnancy Vitamins Cut Leukemia in Kids - WebMD, 12/6/01 - "Moms who used both folic acid and iron supplements in pregnancy were 60% less likely to have a child develop leukemia"
  • Proanthocyanidin Power - Nutrition Science News, 6/00
  • Cancer Prevention Diet - Nutrition Science News, 8/99
  • Immune Enhancers - Nutrition Science News, 2/99

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