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Pulse Pressure

Related Topics:

• hypertension / advanced glycation end products / cholesterol / hardening of the arteries

Alternative News:

• Lycopene supplement and blood pressure: an updated meta-analysis of intervention trials - Nutrients. 2013 Sep 18;5(9):3696-712 - "Six studies met our inclusion criteria, and the pooled analysis demonstrated a significant reduction of systolic blood pressure (SBP) (mean SBP = -4.953 [-8.820, -1.086], p = 0.012) with obvious heterogeneity (p = 0.034, I2 = 58.5%). Subgroup analysis results showed that higher dosage of lycopene supplement (>12 mg/day) could lower SBP more significantly, especially for participants with baseline SBP >120 mmHg, or Asians, while lycopene intervention had no statistical effect on diastolic blood pressure (DBP) (mean DBP = -3.809 [-8.177, 0.560], p = 0.087), and obvious heterogeneity was also observed (p = 0.074, I2 = 53.1%). Our present study suggests that lycopene supplement >12 mg/day might effectively decrease SBP, particularly among Asians or population with higher baseline SBP" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
• Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype - Am J Clin Nutr. 2005 Jul;82(1):26-31 - "5 mg folic acid/d ... Folic acid reduced brachial pulse pressure by 4.7 ... Folic acid is a safe and effective supplement that targets large artery stiffness and may prevent isolated systolic hypertension" - See iHerb folic acid products.
• High Dietary Calcium Intake Associated with Lower Age-Related Hypertension - Doctor's Guide, 7/16/03 - "In industrialized nations, SBP increases with age, whereas diastolic blood pressure (DBP) tends to decrease with age, thereby increasing pulse pressure (defined as the difference between SBP and DBP) ... higher calcium intake was associated with lower rates of age-related increases of systolic blood pressure and pulse pressure ... If the calcium intake of the general population were to increase to above 1,200 mg, the incidence of isolated systolic hypertension in the elderly might be decreased" - See drugstore.com/GNC calcium supplements.
• Combined effect of coenzyme Q(10) and fenofibrate on forearm microcirculatory function in type 2 diabetes - Atherosclerosis 2003 May;168(1):169-79 - "CoQ did not change plasma isoprostanes, but significantly lowered systolic blood pressure and HbA(1c)"
• Coenzyme Q10 Improves High Blood Pressure - New Hope Natural Media, 1/9/03 - "recruited 83 people with a condition called isolated systolic hypertension (ISH), in which the higher blood pressure ... These people were assigned to take either 60 mg of CoQ10 twice daily or a placebo for 12 weeks ... The people taking CoQ10 had an 18-point (18 mm Hg) reduction in systolic blood pressure (from 165 to 147 mm Hg), compared with only a 2-point decline in the placebo group ... ISH is the most common type of high blood pressure in the United States" - See iHerb coenzyme Q10 products.
• Evidence-based Products - Functional Foods & Nutraceuticals, 12/02 - "3g EPA/d and 3g DHA/d (ROPUFA) increased systemic arterial compliance in 38 dyslipidemic men and women, resulting in reduced pulse pressure and total vascular resistance ... Results showed that ROPUFA increased SAC—36 per cent with EPA and 27 per cent with DHA—compared with placebo" - See Mega Twin EPA at iHerb and Jarrow Max DHA at Amazon.com.

Other News:

• Nighttime ambulatory pulse pressure predicts cardiovascular and all-cause mortality among middle-aged participants in the 21-year follow-up - J Clin Hypertens (Greenwich) 2021 Jul 3 - "high ambulatory nighttime PP was detected as a long-term risk factor for CV and all-cause mortality in middle-aged individuals"
• Association of pulse pressure with all-cause and cause-specific mortality - J Hum Hypertens. 2020 Apr 7 - "The association of PP with all-cause and other causes of mortality was significant, and the adjusted HRs (95% CIs) were 1.16 (1.06-1.28), and 1.18 (1.00-1.40), respectively. On subgroup analyses, PP was positively associated with all-cause and cardiovascular disease (CVD) in participants <65 years or males and positively associated with other causes of mortality in males. The risk of all-cause and other causes of mortality increased with increasing PP in a rural Chinese population. Higher PP may increase the risk of all-cause and CVD mortality for males and people <65 years as well as the risk of other causes of mortality for males in rural Chinese people"
• Association between pulse pressure and aortic calcification: Findings from the National Health and Nutrition Examination Survey 2013-2014 - J Clin Hypertens (Greenwich). 2020 Apr 6 - "abdominal aortic calcification (AAC) ... PP was a predictor of the presence of AAC in fully adjusted models in adults <60 years of age (OR 1.31, P < .05) and ≥60 years of age (OR 1.33, P < .05). PP was also associated with the magnitude of AAC in the overall sample but did not retain significance after separating by age-groups and additionally adjusting for antihypertensive medication. In conclusion, PP is associated with the presence of AAC as measured by DXA in a nationally representative sample of US adults"
• Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults - Neurology. 2013 Nov 13 - "One hundred seventy-seven cognitively normal, stroke-free older adult participants (aged 55-100 years) underwent blood pressure assessment for determination of PP (systolic - diastolic blood pressure) ... PP elevation is associated with increased CSF P-tau and decreased Aβ1-42 in cognitively normal older adults, suggesting that pulsatile hemodynamics may be related to amyloidosis and tau-related neurodegeneration. The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life"
• Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial - HYVET - J Hypertens. 2013 Jun 5 - "High blood pressure (BP) has been associated with increased risk of dementia. Concerns have been raised about lowering BP too far in the very elderly and thereby increasing risk. There is some evidence to suggest a potential 'J'-shaped relationship between DBP and risk of cognitive impairment ... trial of antihypertensives in patients aged at least 80 years with an untreated SBP of 160-199 mmHg. Active medication was indapamide sustained release 1.5 mg+/- perindopril 2-4 mg to reach goal pressure of less than 150/80 mmHg ... mean follow-up of 2.2 years ... baseline DBP was inversely related to incident dementia (P = 0.0064). Achieved DBP did not predict later dementia in the placebo group (P = 0.43), but showed a U-shaped relationship in the active treatment group (P = 0.0195). The relationship between incident dementia and DBP did however not differ significantly between the placebo and active treatment groups (P = 0.38). SBP was not associated with incident dementia, at baseline (P = 0.62) or during follow-up (placebo group P = 0.13, active group P = 0.36). Wider achieved pulse pressure (PP) was associated with increased risk of dementia in both treatment groups (placebo P = 0.032, active P = 0.0046). The same tendency was observed for baseline PP ... Wider PP may possibly indicate an increased risk for dementia. Active treatment may act to change the shape of the relationship between DBP and dementia"
• Effects of Low-Dose Atorvastatin on Arterial Stiffness and Central Aortic Pressure Augmentation in Patients With Hypertension and Hypercholesterolemia - Am J Hypertens. 2013 Feb 28 - "50 hypertensive and hypercholesterolemic patients were allocated to receive 10mg of atorvastatin or placebo for 26 weeks ... At study end, aortic PWV (9.0+/-1.5 vs. 10.9+/-2.6 m/sec; P<0.001) and AIx(75) (24.9% +/- 9.7% vs 28.8% +/- 11.8%; P < 0.001) were significantly lower in the atorvastatin group than that placebo group. Furthermore, decreases in central aortic systolic blood pressure and pulse pressure were evident at study-end with atorvastatin but not with placebo (130+/-8 vs. 138+/-6mm Hg, P < 0.001; 48+/-7 vs. 53+/-6mm Hg, P < 0.05, respectively). Atorvastatin-induced reductions in aortic PWV during follow-up showed significant associations with changes in AIx(75) and central aortic systolic blood pressure and pulse pressure"
• Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study) - Diabetes Care. 2011 Feb 17 - "PP was higher at baseline in patients who experienced a CVD event (66 +/- 18 vs. 52 +/- 14 mmHg; P < 0.001) or progressed in their renal status (58 +/- 18 vs. 54 +/- 15 mmHg; P < 0.01) during follow-up. In a Cox regression model, PP was independently associated with a first ever CVD event (hazard ratio per 10 mmHg 1.22 [95% CI 1.10-1.34]) but not progression of renal disease (1.00 [0.89-1.12]) after adjustments for traditional risk factors. CONCLUSIONS PP, a marker of arterial stiffness, is a risk factor for cardiovascular complications but not for diabetic nephropathy in patients with T1D"
• Arterial Stiffness and Memory and Concentration - Medscape, 11/23/07 - "Increasing pulse-pressure levels and higher baseline pulse-wave velocity — indications of increased arterial stiffness — were linked to a decline in memory and concentration among aging individuals who participated in the Baltimore Longitudinal Study of Aging"
• Pulse Pressure May Be the Best Predictor of CV Mortality - Medscape, 10/11/05 - "Pulse pressure and diastolic and systolic BPs were the best predictors for CVD death followed by mean and mid BPs"
• Systolic Better Than Diastolic Or Pulse Blood Pressure As Indicator Of Mortality Risk - Doctor's Guide, 11/4/03 - "Rising systolic blood pressure is the clearest indicator for increased risk of death compared to other blood pressure measurements ... Systolic pressure, which is the higher number and first number in a blood pressure reading, measures the force of blood in the arteries as the heart contracts to push blood through the body"
• Isolated Systolic Hypertension Carries Significant Structural And Functional Alterations - Doctor's Guide, 5/21/03 - "Alterations in arterial structure and function identified in patients with isolated systolic hypertension may be responsible for their higher morbidity and mortality compared to patients with systolic and diastolic hypertension"
• Angiotensin II Receptor Blockers Effective, Better Tolerated than Calcium Channel Blockers in Elderly Patients - Doctor's Guide, 5/21/03 - "Valsartan and amlodipine are both highly effective in controlling blood pressure in patients with isolated systolic hypertension ... However, valsartan offers a significant tolerability advantage as it shows a reduced risk of developing adverse events"
• Amlodipine Alone or in Combination with other Drugs Reduces Systolic Blood Pressure - Doctor's Guide, 5/21/03 - "The mean reduction in systolic blood pressure was approximately 17 mm Hg, while diastolic blood pressure decreased an average of 8 mm Hg, irrespective of regimen"
• Retinal Abnormalities Age-Related Macular Degeneration Associated With Hypertension, Pulse Pressure - Doctor's Guide, 4/10/03 - "Retinal abnormalities in older people without diabetes are related to hypertension. Higher blood and pulse pressure are also associated with an increased incidence of macular abnormalities, including wet and dry age-related macular degeneration (AMD)"
• Higher Pulse Pressure Tied To Dementia Risks - Doctor's Guide, 3/17/03 - "Higher pulse pressure in older adults is linked with increased risk for Alzheimer disease (AD) and dementia, which is probably caused by artery stiffness and severe atherosclerosis" - Note:  Pulse pressure is the difference between the systolic (high number) and diastolic (low number).
• High Pulse Pressure May Help Identify Young Hypertensives At Higher Risk Of Cardiovascular Events - Doctor's Guide, 10/2/02
• Treating To Lower Blood Pressure Goal Reduces Aortic Stiffness - Doctor's Guide, 9/30/02
• Sildenafil Improves Arterial Pressure and Compliance in Hypertensive Heart Transplant Recipients - Doctor's Guide, 9/27/02
• Pulse Pressure Linked To Cardiovascular Mortality Among Type 2 Diabetics - Doctor's Guide, 9/3/02
• Aortic Pulse Pressure May Predict Extent Of Coronary Artery Disease - Doctor's Guide, 8/29/02
• Pulse Pressure a Better Predictor of Mortality than Mean Blood Pressure - Doctor's Guide, 1/28/02
• Blood Pressure Measures During Exercise Can Indicate Unhealthy Hearts - Doctor's Guide, 9/17/01 - "a high pulse pressure -- defined as the difference between systolic blood pressure and diastolic blood pressure -- during exercise was associated with a dysfunction of the endothelial cells lining the blood vessels"
• Experimental Drug Decreases Age-Related Blood Vessel Stiffening - Doctor's Guide, 9/5/01
• Most Doctors Still Overlook Systolic Blood Pressure In Hypertensives - Doctor's Guide, 11/1/00
• New Risk Factor In Cardiovascular Disease -- Pulse Pressure - Doctor's Guide, 5/25/99
• Pulse Pressure Serves As Marker For Heart Disease Death - Doctor's Guide, 12/8/97

Abstracts:

• Pulse pressure and heart rate in patients with metabolic syndrome across Europe: insights from the GOOD survey - J Hum Hypertens. 2012 Dec 13 - "When compared with patients with no metabolic syndrome or diabetes, patients with metabolic syndrome had higher pulse pressure (59+/-14 vs 55+/-14 mm Hg) and heart rate (75.2+/-11.0 vs 72.5+/-10.0 beats per min) (P<0.001 for both), independent of the concomitant presence or absence of diabetes, despite a more prevalent use of β-blockers. In conclusion, in hypertensive outpatients the presence of metabolic syndrome is associated with increased heart rate and pulse pressure, which may at least in part reflect increased arterial stiffness and increased sympathetic tone"
• Pulse Pressure, Prehypertension, and Mortality: The San Antonio Heart Study - Am J Hypertens. 2009 Aug 20
• The Relation Between Pulse Pressure and Cardiovascular Mortality in 12 763 Middle-aged Men From Various Parts of the World: A 25-Year Follow-up of the Seven Countries Study - Arch Intern Med. 2005 Oct 10;165(18):2142-7 - "The age-adjusted hazard ratio per 10–mm Hg increase in pulse pressure varied among cohorts from 1.19 in the United States (P = .04) to 1.29 in southern Europe ... pulse pressure measurements were also a significant predictor for coronary heart disease (hazard ratio per 10–mm Hg increase, 1.15; P = .04) as well as stroke death"
• Dietary calcium lowers the age-related rise in blood pressure in the United States: the NHANES III survey - J Clin Hypertens (Greenwich). 2003 Mar-Apr;5(2):122-6 - "higher calcium intake was associated with lower rates of age-related increases of systolic blood pressure and pulse pressure (p<0.001). If the calcium intake of the general population were to increase to above 1200 mg, the incidence of isolated systolic hypertension in the elderly might be decreased"