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Home > Anti-aging Research > Estrogen


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  • Taurine promotes estrogen synthesis by regulating microRNA-7a2 in mice ovarian granulosa cells - Biochem Biophys Res Commun 2022 Aug 6 - "These results suggest that taurine promotes E2 synthesis through p38/miR-7a/Glg1/Cyp19a1 signaling pathway, which is crucial to understand the function and mechanism of taurine on estrogen synthesis" - See taurine at Amazon.com.
  • Silymarin Improves Vascular Function of Aged Ovariectomized Rats - Phytother Res. 2013 Sep 30 - "Both aging and estrogen depletion lead to endothelial dysfunction, which is the main reason of many cardiovascular diseases ... silymarin (SM) ... In spite of the presence of estrogen antagonist, immediate SM treatment restored the endothelial function and vascular tone better than estrogen replacement. Additionally, as a complementary and alternative medicine, it does not cause estrogenic side effects when taken acutely" - See silymarin at Amazon.com.
  • Resveratrol could prove HRT alternative, study - Nutra USA, 11/23/09 - "While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein ... Because it (resveratrol) stimulated the transcription of endogenous estrogen receptor (ER) and proapoptotic effects, this phytoestrogen is the most promising candidate as an HRT alternative and chemopreventive reagent for breast cancer ... The researchers added that their results indicated that daidzein causes a slight cell-stimulating effect in the absence of E2, which may lead to an increased risk of breast cancer in postmenopausal women taking supplements containing these phytoestrogens" - [Abstract] - See resveratrol products at Amazon.com.
  • Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells - J Nutr Biochem. 2009 Oct 2 - "While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein. Moreover, resveratrol significantly enhanced p53-dependent transcriptional activity, but slightly reduced NF-kappaB-dependent transcriptional activity. On knockdown analysis, genistein, resveratrol and glycitein all reduced the Bcl-2/Bax ratio in the presence of apoptosis-inducing stimuli, and estrogen receptor (ER) alpha silencing had no effect on these reductions. In contrast, in the absence of apoptosis-inducing stimuli, only resveratrol reduced the ratio, and ERalpha silencing abolished this reduction. Thus, resveratrol might be the most promising candidate for HRT and chemoprevention of breast cancer due to its estrogenic activity and high antitumor activity" - See resveratrol products at Amazon.com.
  • Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors - Menopause. 2009 Jul 22 - "Combined hormone therapy (HT) containing estrogen and progestin (medroxyprogesterone acetate [MPA]) leads to increased risk of breast cancer in postmenopausal women, compared with HT regimens containing estrogen alone or placebo ... Treatment with curcumin delayed the first appearance of MPA-accelerated tumors by 7 days, decreased tumor incidence by the end of the experiment, and reduced tumor multiplicity in DMBA-induced MPA-accelerated tumors. Curcumin also prevented many of the gross histological changes seen in the MPA-treated mammary gland. Immunohistochemical analyses of mammary tumors showed that curcumin decreased MPA-induced VEGF induction in hyperplastic lesions, although it did not affect the levels of estrogen and progesterone receptors" - See curcumin products at Amazon.com.
  • Asian Spice Could Reduce Breast Cancer Risk In Women Exposed To Hormone Replacement Therapy - Science Daily, 7/13/09 - "curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women after exposure to hormone replacement therapy ... curcumin delayed the first appearance, decreased incidence and reduced multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands" - See curcumin products at Amazon.com.
  • A Different Side of Estrogen - Science News Online, 1/508 - "estrogen-like compounds called phytoestrogens are found in foods including soy and coffee. Some scientists have speculated that phytoestrogens played a key role in the lower incidence of prostate and breast cancers found for many years in Asian populations with soy-based diets"
  • 'Natural' Menopause Hormones: Hype or Hope? - WebMD, 11/4/05
  • Alternatives to Estrogen? - Dr. Weil, 7/12/05
  • Natural Female Hormone Replacement - Life Extension Magazine, 4/05
  • Sizing Up Alternatives to Hormones - Intelihealth, 3/30/05
  • Safe Hormone Strategy? - Dr. Weil, 5/10/04
  • Grape Seed Extract May Be A Useful Supplement To Blunt Hypertension In Postmenopausal Women - Intelihealth, 4/10/03 - "a diet moderately high in grape seed extract can blunt salt (sodium chloride)-sensitive hypertension to about the same extent as treatment with either plant estrogens or 17ß-estradiol. This suggests that mechanisms other than the estrogen receptor activation actually provides the beneficial effects of estrogen therapy and that grape seed extract may be a useful supplement to blunt hypertension and other cardiovascular symptoms in postmenopausal women" - See iHerb or Vitacosticon grape seed extract products.
  • Red Clover May Tame Hot Flashes - WebMD, 8/16/02 - "Promensil is an isoflavone supplement produced from red clover and contains the same key isoflavones commonly found in soy foods. Isoflavones are plant compounds -- found commonly in soy -- that act like weak form of the female sex hormone estrogen ... Only red clover contains all four isoflavones that women need ... 30 women were given either 40 mg of Promensil or a placebo for 16 weeks. The group taking Promensil reported a 48% reduction in frequency of hot flashes, whereas the control group had an 11% decrease" - See iHerb and Vitacosticon Promensil products.
  • Alternatives to HRT - Dr. Janson's Newsletter, 8/02
  • Hormone Replacement: What Now for Women? - Dr. Weil, 7/18/02 - "You can protect against bone loss with weight bearing exercise and strength training, by making sure you get 1,500 mg of calcium plus 400 IU of vitamin D daily, by not smoking and minimizing your intake of caffeine, sodas, and excessive protein. If you’ve already lost bone, Evista (raloxifene) the first of a new generation of drugs -- selective estrogen receptor modifiers, or SERMs – seems to protect against bone loss while actually reducing the risk of breast cancer ... Many women get relief from hot flashes and other menopausal discomforts with black cohosh (Cimifiuga racemosa) plus 800 IUs of Vitamin E daily"
  • Alternatives to HRT - WebMD, 7/10/02 - "A powerful class of drugs called statins reduce the amount of cholesterol in the blood -- especially LDL, the so-called "bad" cholesterol. Statins have also been found to reduce stroke, may reduce osteoporosis, could be an adjunct treatment for cancer ... different proteins found in natural soy appear to interact with phytoestrogens -- plant estrogens -- to increase their cholesterol-lowering activity ... Limiting salt in the diet -- and walking 30 minutes a day -- can also lower blood pressure ... Fosamax and similar bisphosphonate medications are designed to prevent or treat osteoporosis ... Calcium and vitamin D supplements -- to the tune of 1,500 mg a day -- are recommended for older women and men ... 30 minutes of weight-bearing and strength-training exercise ... Soy seems to be an effective short-term treatment to quell hot flashes and night sweats ... Several studies published this year found evidence in favor of black cohosh, which is an herb and an ancient Native American remedy for hot flashes ... Antidepressants -- including Prozac and Effexor -- have been shown to cool hot flashes"
  • Black Cohosh Controls Menopausal Symptoms - Medscape, 6/24/02 - "In double-blind fashion, the women received daily treatment for three months with commercially available black cohosh (Klimadynona or Menofema, 40 mg), conjugated estrogens (0.6 mg), or placebo ... Both black cohosh and estrogen reduced major climacteric complaints significantly more than did placebo (P<.05). Black cohosh improved blood lipid and bone-specific alkaline phosphatase levels. Although estrogen increased endometrial thickness, black cohosh did not"
  • Serum Folate And Estradiol Levels Interact In Alzheimer's Disease - Doctor's Guide, 5/13/02 - "a high ratio of estradiol to total estrogens is linked with AD. At the same time, in women with a high ratio, the severity of dementia is lower in those with high serum folate levels ... If this association is causal, then supplementation with folic acid may have a role in future studies of estrogen replacement therapy (ERT) in Alzheimer's disease (AD)"
  • Tofupill Phytoestrogen Preparation Relieves Menopausal Symptoms without Unwanted Estrogenic Effects - Doctor's Guide, 5/6/02
  • Some Herbs Can Mimic Estrogen - WebMD, 4/10/02 - "Motherwort leaf, saw palmetto berry, Rhodiola rosea root, and red clover blossom interacted strongly with the rats' estrogen receptors, indicating that they have a strong estrogen-like effect in the body. Dang gui root, black and blue cohosh, vitex berry, hops flower, wild yam, and licorice root also showed some estrogen-like effects. Maca root, cramp bark, and turmeric root showed the weakest estrogen effect"
  • Herb Fights Menopause Symptoms - WebMD, 3/28/02 - "New research suggests that a black cohosh extract, marketed as Remifemin, works differently from estrogen, which has been linked to an increase in breast cancer risk ... As many as 80% will experience menopausal symptoms such as hot flashes, mood swings, night sweats, and bouts of insomnia ... These days, many different manufacturers market black cohosh supplements. But Remifemin is the only one that has been extensively studied"
  • Estrogen's Two-Way Street - Nutrition Science News, 11/01 - "Studies show that when 2-hydroxylation increases, the body resists cancer, and that when 2-hydroxylation decreases, cancer risk increases ... Cell-culture studies and human clinical trials have shown that I3C at doses of 200­400 mg/day can influence estrogen metabolism and promote formation of 2-OH-estrone, and therefore may be useful in breast cancer prevention"
  • Is Soy Better Than Estrogen for Heart Health After Menopause? - WebMD, 7/2/01 - "This research is interesting as it suggests soy can favorably affect cholesterol without adversely affecting blood clotting, which is a potential concern with estrogen replacement ... benefits were seen equally in men and women, [and] soy treatment did not affect male sexuality"
  • Soy Does Not Activate Blood Clotting Mechanisms - Doctor's Guide, 6/22/01 - "We know that soy reduces cholesterol and blood pressure, so it appears to be a healthy intervention, and it does not appear to increase the risk of blood clotting, so it continues to be a safe dietary recommendation for patients"
  • The Replacements - Nutrition Science News, 8/99
  • Estrogen Therapy? Don't Worry - Life Extension Magazine, 10/99
  • Extra Calcium Benefits Women On Hormone Replacement Therapy - Doctor's Guide, 1/15/98 - "women who consumed high levels of calcium in conjunction with hormone replacement therapy (HRT) had much greater increases in bone mass than those who used either estrogen or calcitonin alone"

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