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Macular Degeneration
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Alternative News:
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NMN Shown To Remove Senescent Cells In
Aging Eyes - YouTube, Modern Healthspan - See
NMN at Amazon.com.
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Cordyceps militaris
Carotenoids Protect Human Retinal Endothelial Cells against the Oxidative Injury
and Apoptosis Resulting from H2O2 - Evid Based Complement Alternat Med 2022
Sep 30 - "Vision loss is primarily caused by age-related
macular degeneration (AMD) due to oxidative retinal pigment epithelial (RPE)
cell injury. Carotenoid utilization is deemed a possible strategy for treating
AMD. Cordyceps militaris has advantages like immunomodulatory,
anti-inflammatory, and antioxidative characteristics ... The findings
demonstrated that CMCT safeguarded the ARPE-19 cells against the damage and
apoptosis caused by H2O2 and oxidative stress via Bcl-2 protein upregulation, as
well as the expression of Bax and cleaved caspase-3 protein. In addition, CMCT
treatment increased cell survival and restricted the generation of H2O2-induced
reactive oxygen species (ROS) and the protein expression of NADPH oxidase-1
(NOX1). Additionally, the CMCT treatment of H2O2-induced ARPE-19 cells
ameliorated high malondialdehyde (MDA) levels in oxidative stress-induced cells.
The catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH)
returned to standard levels, which were governed by the higher expression of
nuclear Nrf2 protein in the ARPE-19 cells. Moreover, this study showed that CMCT
safeguarded the ARPE-19 cells against the damage caused by oxidative stress via
its antioxidant activity and antiapoptotic functionality, suggesting the
potential therapeutic role of CMCT in AMD prevention and mitigation" -
See cordyceps militaris at Amazon.com.
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Linkage between a
plant-based diet and age-related eye diseases: a systematic review and
meta-analysis - Nutr Rev 2022 Sep 14 -
"Meta-analysis indicated regular consumption of fish (odds ratio [OR], 0.70;
95%CI, 0.62-0.79) and skim milk, poultry, and non-meat animal products (OR,
0.70; 95%CI, 0.61-0.79) reduced the risk of age-related eye disease development
among adults. Consumption of red meat (OR, 1.41; 95%CI, 1.07-1.86) may increase
the risk of age-related eye disease development"
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Nicotinamide
Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium
Iodate in RPE - Oxid Med Cell Longev 2022 Jul 18 -
"retinal pigment epithelium (RPE) ... The protective effects of NMN were demonstrated to rely on undisturbed Sirt1
signaling. Moreover, both the expression of senescence markers of RPE and subretinal inflammatory cell infiltration were decreased by NMN treatment in
vivo. Our results indicate that RPE senescence induced by NaIO3 acquired several
key features of AMD. More importantly, NMN may potentially be used to treat RPE
senescence and senescence-associated pre-AMD changes by restoring the NAD+
levels in cells and tissues." - See
NMN at Amazon.com.
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Intermittent Fasting is
Associated with a Decreased Risk of Age-related Macular Degeneration:
Intermittent fasting and age-related macular degeneration - Am J Ophthalmol
2022 Jul 6 - "The intermittent fasting group had a
decreased risk of AMD compared to the non-fasting group (adjusted odds ratio [aOR]
0.413... Using the population-based survey data, we demonstrated that
intermittent fasting by skipping breakfast was significantly associated with a
reduced risk of AMD in a representative elderly population, especially in
individuals with age less than 70 years, obesity, and urban residence"
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Metformin Shows Potential
to Prevent Macular Degeneration - Medscape, 7/18/22 -
"patients who were prescribed the drug over a period of
2 years were about 5% less likely to have AMD ... But the drug has previously
shown protective effects against other age-related diseases such as dementia,
cancer, and stroke. And it works through pathways that play a role in the
development of AMD ... Those patients prescribed low to moderate doses of
metformin had the least risk. Those prescribed 1-270 grams over 2 years had an
OR of 0.91 (95% CI, 0.88 - 0.94). And those prescribed 271-600 grams over 2 two
years had an OR of 0.90 (95% CI, 0.87 - 0.93). But patients prescribed doses
over 1080 grams over 2 years did not have reduced odds of developing AMD ... On
the other hand, people prescribed the diabetes drugs exenatide, sitagliptin, or
pramlintide instead of metformin were at higher risk of developing AMD (OR,
1.08" - See
metformin at ReliableRX.
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Dietary omega-3
polyunsaturated fatty acids and fish intake and risk of age-related macular
degeneration - Clin Nutr 2021 Oct 12 - "Higher
dietary intakes of omega-3 PUFA was significantly associated with 14% (relative
risk [RR]: 0.86, 95% confidence interval [CI]: 0.77, 0.96) and 29% (RR: 0.71,
95% CI: 0.55, 0.91) lower risk of early and late AMD, respectively. The
dose-response analysis showed a 6% and 22% decrease in the risk of early and
late AMD for each additional 1 g/d omega-3 PUFA intake. For individual omega-3
PUFA, the intake of eicosapentaenoic acid and docosahexaenoic acid was inversely
associated with lower AMD risk, whereas no association was found for the alpha-linolenic
acid. Consistent inverse associations were also found between fish intake and
AMD. The pooled RRs comparing extreme categories of fish intake were 0.79 (95%
CI: 0.70, 0.90) and 0.71 (95% CI: 0.60, 0.85) for early and late AMD risk,
respectively. Every 15 g/d of fish consumption was associated with 13% and 14%
lower early and late AMD. In addition, fish intake was associated with a
significantly reduced risk of AMD progression (RR: 0.73" - See
omega-3 supplements at Amazon.com.
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Causal Effects of N-6
Polyunsaturated Fatty Acids on Age-related Macular Degeneration: A Mendelian
Randomization Study - J Clin Endocrinol Metab 2021 May 13 -
"Our study provided genetic evidence that circulating LA
accounted for protective effects of n-6 PUFAs against the risk of AMD, whereas
AA was responsible for deleterious effects on higher AMD risk"
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Role of Resveratrol in
Transmitochondrial AMD RPE Cells - Nutrients. 2020 Jan 6;12(1) -
"treatment with different resveratrol formulations
improved cell viability and decreased reactive oxygen species generation in each
AMD patient cell line. Although further studies are required to establish the
cytoprotective potential of resveratrol under different physiological
conditions, this novel study established the positive effects of OTC resveratrol
supplements in macular degeneration patient cybrid cell lines in vitro" -
See resveratrol products at Amazon.com.
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Consumption of eggs and
the 15-year incidence of age-related macular degeneration - Clin Nutr. 2019
Mar 16 - "Our findings suggest that moderate consumption of eggs significantly
reduces the risk of developing incident late-stage AMD over 15 years"
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Mediterranean diet prevents a leading cause of blindness, study suggests -
Science Daily, 10/1/18 - "people who adhered to a Mediterranean diet cut their
risk of late-stage AMD by 41 percent ... A Mediterranean diet emphasizes eating
less meat and more fish, vegetables, fruits, legumes, unrefined grains, and
olive oil. Previous research has linked it to a longer lifespan and a reduced
incidence of heart disease and cognitive decline ... For this latest study,
researchers analyzed food-frequency questionnaires from nearly 5,000 people who
participated in two previous investigations -- the Rotterdam Study, which
evaluated disease risk in people age 55 and older, and the Alienor Study, which
assessed the association between eye diseases and nutritional factors in people
aged 73 and older"
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Lutein and Zeaxanthin
Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and
Endoplasmic Reticulum Stress in BALB/cJ Mice - Nutrients. 2018 Jun 28;10(7)
- "Our data shows that L/Zi provided functional and
morphological preservation of photoreceptors against light damage, which is
probably related to its mitigation of oxidative and endoplasmic reticulum
stress" - [Nutra
USA]
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An
orange a day keeps macular degeneration away: 15-year study - Science Daily,
7/12/18 - "people who ate at least one serving of
oranges every day had more than a 60% reduced risk of developing late macular
degeneration 15 years later ... the data showed that flavonoids in oranges
appear to help prevent against the eye disease ... Flavonoids are powerful
antioxidants found in almost all fruits and vegetables, and they have important
anti-inflammatory benefits for the immune system"
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Oral Omega-3
Supplementation Lowers Intraocular Pressure in Normotensive Adults - Transl
Vis Sci Technol. 2018 May 1;7(3):1 - "These findings justify further
investigation into the therapeutic potential of omega-3 supplementation for
reducing IOP, to prevent and/or treat conditions with IOP elevation, including
ocular hypertension and glaucoma" - [Nutra
USA] - See omega-3 supplements at
Amazon.com.
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Protective Effects of
Blueberry Anthocyanins against H2O2-Induced Oxidative Injury in Human Retinal
Pigment Epithelial Cells - J Agric Food Chem. 2018 Feb 2 -
"These combined
results supported the hypothesis that blueberry anthocyanins could inhibit the
induction and progression of age-related macular degeneration (AMD) through
antioxidant mechanisms" - See
blueberry extract at Amazon.com
 .
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Antioxidant/zinc supplement cost saving and effective for degenerative eye
disease - Science Daily, 8/23/17 - "A supplement that combines antioxidants
with zinc and copper is a relatively inexpensive and effective means of halting
the progression of a certain type of degenerative eye disease" - Note: It
talks about the same study as the WebMD article below but emphasizes zinc and
copper. My problem with the AREDS 2 formula is that it duplicates a lot of
what you may already be taking. Also, some studies claim that taking zinc
can cause a copper deficiency. See
Jarrow Zinc Balance at Amazon.com.
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Zinc May Help Against Vision Loss in Seniors - WebMD, 8/23/17 -
"AREDS was "greatly cost-effective for the
treatment of age-related macular degeneration, specifically in people who have
active wet, age-related macular degeneration in one eye and dry in the other ... Formula 1 has high doses of vitamins C and E, beta
carotene, zinc and copper. Formula 2 has lutein and zeaxanthin instead of beta
carotene ... both formulations were cost effective for treating patients with
early stage disease, but they were even more cost effective for those with the
condition in only one eye ... these patients would need nearly eight fewer
injections of anti-VEGF therapies into their eye" - See
AREDS 2 at Amazon.com.
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An Eye
to Health: Diet and Age-Related Macular Degeneration - Medscape, 6/27/17 -
"The Age-Related Eye Disease Study (AREDS) found
that a specific formulation of antioxidants and minerals, including vitamin C,
vitamin E, beta-carotene, zinc, and copper, reduced the risk of patients with
intermediate AMD developing the advanced form of the condition by 25% over 5
years.[12] Subsequently, the follow-up AREDS 2 study found that lutein and
zeaxanthin can be substituted for beta-carotene, which has been linked to
increased risk for lung cancer, particularly among former smokers ... Beyond
high-dose supplementation, intake of antioxidants and omega-3 long-chain
polyunsaturated fatty acids through daily diet has also been reported to reduce
AMD risk ... a high glycemic index (GI) diet is a risk factor for AMD.[9,17] The
GI represents a food's impact on blood glucose levels relative to pure glucose
(GI = 100). Consumption of higher-GI foods results in higher blood glucose
levels. High GI foods (GI > 70) include white rice, white bread, and potatoes,
whereas whole grains, lentils, and nonstarchy vegetables such as broccoli and
cabbage have a low GI (GI < 55). High-GI diets are associated with accumulation
of advanced glycation end-products (AGEs) that are formed when cellular proteins
are modified by sugar molecules or their metabolites"
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Mediterranean Diet May Cut AMD Risk by More Than a Third - Medscape,
10/19/16 - "Several studies have shown that vitamin A,
vitamin C, vitamin E, lutein, antioxidants, and omega-3 help protect against
age-related macular degeneration and have health benefits beyond ophthalmology
... A score of 9 indicated a Mediterranean-style diet, whereas a score of 0
indicated a completely different diet ... The risk for macular degeneration was
35% lower in people with a score below 6 than in those with a score of 6 or
higher (50% vs 39%)"
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Lutein, Zeaxanthin and
Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density
- Nutrients. 2016 Jul 12;8(7) - "macular pigment optical
density (MPOD) ... This meta-analysis revealed that lutein, zeaxanthin and
meso-zeaxanthin supplementation improved MPOD both in AMD patients and healthy
subjects with a dose-response relationship" - See
carotenoids at Amazon.com.
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Intakes of Lutein,
Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2
Decades of Prospective Follow-up - JAMA Ophthalmol. 2015 Oct 8 -
"Comparing extreme quintiles of predicted plasma lutein/zeaxanthin
score, we found a risk reduction for advanced AMD of about 40% in both women and
men (pooled relative risk comparing extreme quintiles = 0.59; 95% CI, 0.48-0.73;
P for trend < .001). Predicted plasma carotenoid scores for other carotenoids,
including β-cryptoxanthin, α-carotene, and β-carotene, were associated with a
25% to 35% lower risk of advanced AMD when comparing extreme quintiles. The
relative risk comparing extreme quintiles for the predicted plasma total
carotenoid index was 0.65" - [Nutra
USA] - See
carotenoids at Amazon.com.
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Vitamin
D may play key role in preventing macular degeneration - Science Daily,
8/31/15 - "women who are deficient in vitamin D and have
a specific high-risk genotype are 6.7 times more likely to develop AMD than
women with sufficient vitamin D status and no high risk genotype ... Vitamin D
shows promise for protecting against macular degeneration because of its
anti-inflammatory and antiangiogenic properties; antiangiogenic refers to
slowing the growth of new blood vessels, often seen in late stages of AMD ...
Our study suggests that being deficient for vitamin D may increase one's risk
for AMD, and that this increased risk may be most profound in those with the
highest genetic risk for this specific variant in the CFH protein" - See
vitamin D at Amazon.com.
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The impact of supplemental
macular carotenoids in Alzheimer's disease: a randomized clinical trial - J
Alzheimers Dis. 2015;44(4):1157-69 - "supplemented for
six months with either Macushield (10 mg meso-zeaxanthin [MZ]; 10 mg lutein [L];
2 mg zeaxanthin [Z]) or placebo (sunflower oil) ... supplementation with the
macular carotenoids (MZ, Z, and L) benefits patients with AD, in terms of
clinically meaningful improvements in visual function and in terms of MP
augmentation" - [Nutra
USA] - See Macushield at Amazon.com.
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Sustained supplementation
and monitored response with differing carotenoid formulations in early
age-related macular degeneration - Eye (Lond). 2015 Jul;29(7):902-12 -
"macular pigment (MP) ... meso-zeaxanthin (MZ) ... contrast sensitivity (CS) ...
In early AMD, MP can be augmented with a variety of supplements, although the
inclusion of MZ may confer benefits in terms of panprofile augmentation and in
terms of CS enhancement" - [Nutra
USA] - See supplements containing
Meso-zeaxanthin at Amazon.com.
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Vitamin A is for anti-aging, at least when it comes to vision - The
Washington Post, 7/14/15 - "There are essentially two
forms of the vitamin: retinoids, or preformed vitamin A, found in animal
products and carotenoids; and provitamin A, dark-colored plant pigments that are
converted to vitamin A in the body ... Food sources: Liver, shrimp, salmon,
sardines, halibut, cod, beef, lamb, eggs, whole milk, whole yogurt ...
Carotenoids are antioxidants that prevent and repair cellular damage and aging
and reduce inflammation in the eyes and elsewhere in the body. The carotenoids
lutein and zeaxanthin are found in the retina of the human eye and have been
shown to help prevent age-related macular degeneration. Carotenoids also may
reduce the risk for cancer ... Food sources: Spinach, kale, Swiss chard, other
dark leafy greens, carrots, sweet potatoes, winter squash, apricots and
cantaloupe ... Not only does vitamin A help with eyesight by producing the
pigments of the retina and preventing macular degeneration, but it also helps
create and maintain healthy skin (hence the popularity of topical Retin-A
skincare products) ... Avoid excessively bright light from harsh interior
lighting or strong sunlight. Most offices are twice as bright as they need to
be. Use low-intensity light bulbs and floor lamps instead of fluorescent
lighting" - See Puritan's Pride Lutein 20 mg with Zeaxanthin-120 Softgels at Amazon.com
 .
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Resveratrol
attenuates CXCL11 expression induced by proinflammatory cytokines in retinal
pigment epithelial cells - Cytokine. 2015 Apr 15 -
"Dysfunction of the retinal pigment epithelium (RPE) resulting from chronic
inflammation is implicated in the pathogenesis of age-related macular
degeneration (AMD) ... Resveratrol substantially inhibited the proinflammatory
cytokines-induced CXCL11 production while partially blocking nuclear factor-κB
activation. This inhibitory action of resveratrol was also observed for the
cytokines-induced expression of chemokines CXCL9, CCL2 and CCL5. Our results
indicate that resveratrol could potentially attenuate RPE inflammatory response
implicated in the pathogenesis of AMD" - See
ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count
at Amazon.com
 .
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Lutein supplementation
leads to decreased soluble complement membrane attack complex sC5b-9 plasma
levels - Acta Ophthalmol. 2015 Mar;93(2):141-5 -
"All subjects were randomly assigned to receive a 10 mg daily dose of lutein or
a placebo for a time period of 1 year ... Lutein supplementation inhibits the
systemic activation of the complement system, which provides further functional
evidence for the reported beneficial effects of this carotenoid in the
management of AMD" - [Nutra
USA] - See
lutein at Amazon.com.
I'm still sticking with mixed carotenoids. See
Jarrow Formulas, CarotenALL at Amazon.com
or
Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
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Omega-3
inhibits blood vessel growth in age-related macular degeneration - Science
Daily, 6/17/14 - "Age-related macular degeneration
(AMD), which is characterized by choroidal neovascularization (CNV), or blood
vessel growth, is the primary cause of blindness in elderly individuals of
industrialized countries ... the omega (ω)-3 long-chain polyunsaturated fatty
acids (LCPUFAs), DHA and EPA, and their specific bioactive products derived from
the cytochrome P450 (CYP) pathway, can influence choroidal neovascularization
(CNV) and vascular leakage by modulating micro-environmental immune cell
recruitment to the site of these lesions ... Given the prevalence of neovascular
eye disease, the potential impact of this study is highly significant. We have
identified unique endogenous lipid biometabolites that are able to inhibit
pathologic retinal angiogenesis, a major driver of vision loss worldwide"
- See
fish oil supplements at Amazon.com.
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Consumption
of dairy products and the 15-year incidence of age-related macular degeneration
- Br J Nutr. 2014 Feb 6:1-7 - "In the Blue Mountains Eye
Study, 2037 participants aged 49 years or above at baseline were re-examined at
follow-up in 1997-9, 2002-4 and/or 2007-9. AMD was assessed from retinal
photographs. Dietary data were collected using a semi-quantitative FFQ, and
servings of dairy product consumption calculated ... a significant linear trend
(P for trend = 0.003) was observed with decreasing consumption of total dairy
foods and the 15-year incidence of late AMD, comparing the lowest v. highest
quintile of intake (OR 2.80, 95 % CI 1.21, 3.04). Over the 15 years, decreased
consumption of reduced-fat dairy foods was associated with an increased risk of
incident late AMD, comparing the lowest to highest quintile of intake (OR 3.10,
95 % CI 1.18, 8.14, P for trend = 0.04). Decreasing total dietary Ca intake over
the 15 years was also associated with an increased risk of developing incident
late AMD"
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Lutein + Zeaxanthin and
Omega-3 Fatty Acids for Age-Related Macular Degeneration: the Age-Related Eye
Disease Study 2 (AREDS2) Randomized Clinical Trial - Medscape, 1/16/14 -
"Serum levels of lutein at year 5 were lower in patients
receiving lutein + zeaxanthin and beta carotene than in patients receiving
lutein + zeaxanthin without beta carotene ... The study showed a protective
effect of lutein + zeaxanthin on progression to advanced AMD, with omission of
beta carotene" - Note: I've been mentioning for years that taking
large does of beta carotene can cause a deficiency of some of the over 600
carotenoids. It doesn't mention the amount of beta carotene in this
article. I'm sticking with the broad array formulas of carotenoids.
See
carotenoids at Amazon.com.
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Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular
degeneration - Am J Clin Nutr. 2013 May 1 - "Serum
folate, vitamin B-12, and tHcy were determined from blood samples drawn in
1997-1999 from cohort members aged ≥55 y. AMD was assessed in 1760 survivors
from retinal photographs taken in 2002-2004 and 2007-2009. Total intakes of
folate and vitamin B-12 were assessed by using a food-frequency questionnaire
... Elevated serum tHcy and folate and vitamin B-12 deficiencies predicted
increased risk of incident AMD, which suggests a potential role for vitamin B-12
and folate in reducing AMD risk" - See
folic acid products at Amazon.com
and
vitamin B12 at Amazon.com.
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High
Concentrations of Plasma n3 Fatty Acids Are Associated with Decreased Risk for
Late Age-Related Macular Degeneration - J Nutr. 2013 Feb 13 -
"High dietary intakes of n3 (Ω3) PUFA and fish have been
consistently associated with a decreased risk for age-related macular
degeneration (AMD) ... The Antioxydants Lipides Essentiels Nutrition et Maladies
Occulaires (Alienor) Study is a prospective, population-based study on nutrition
and age-related eye diseases performed in 963 residents of Bordeaux (France)
aged ≥73 y ... After adjustment for age, gender, smoking, education, physical
activity, plasma HDL-cholesterol, plasma TGs, CFH Y402H, apoE4, and ARMS2 A69S
polymorphisms, and follow-up time, high plasma total n3 PUFA was associated with
a reduced risk for late AMD [OR = 0.62 for 1-SD increase (95% CI: 0.44-0.88); P
= 0.008]. Associations were similar for plasma 18:3n3 [OR = 0.62 (95% CI:
0.43-0.88); P = 0.008] and n3 long-chain PUFA [OR = 0.65 (95% CI: 0.46-0.92); P
= 0.01" - Note: 18:3n3 is alpha-linolenic acid (ALA), the form of
omega-3 found in plant sources such as flax. See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Long-term
Use of Aspirin and Age-Related Macular Degeneration - JAMA. 2012 Dec
19;308(23):2469-78 - "Among an adult cohort, aspirin use
5 years prior to observed incidence was not associated with incident early or
late AMD. However, regular aspirin use 10 years prior was associated with a
small but statistically significant increase in the risk of incident late and
neovascular AMD"
-
Antioxidants May
Slow Age-Related Macular Degeneration - Medscape, 12/31/12 -
"Oral antioxidant supplementation, including with lutein
and zeaxanthin, was associated with some benefits in macular function and
morphologic features among patients at high risk for progression to advanced
age-related macular degeneration (AMD) ... This trial and several others
indicate benefits to functional vision with lutein supplementation. What this
trial has demonstrated over and above is the marginal slowing down of
progression along the early AMD severity scale ... Participants in the
supplement arm took a tablet twice daily to provide a daily dose of 12 mg
lutein, 0.6 mg zeaxanthin, 15 mg d-α-tocopherol (vitamin E), 150 mg ascorbic
acid (vitamin C), 20 mg zinc oxide, and 0.4 mg copper gluconate ... At 36
months, the difference in BCVA had increased to approximately 4.8 letters in
favor of the supplement"
-
Regular
Aspirin Use 10 or More Years Ago Associated With Increased Risk of Type of
Age-Related Macular Degeneration - Science Daily, 12/18/12 -
"data from the Beaver Dam Eye Study, a longitudinal
population-based study of age-related eye diseases conducted in Wisconsin ...
The average duration of follow-up was 14.8 years ... regular use of aspirin use
10 years prior to the retinal examination was associated with late AMD (age- and
sex-adjusted incidence, 1.8 percent for users vs. 1.0 percent for nonusers)"
-
Effect of
(R)-α-Lipoic Acid Supplementation on Serum Lipids and Antioxidative Ability in
Patients with Age-Related Macular Degeneration - Ann Nutr Metab. 2012 Jun
1;60(4):293-297 - "A total of 62 patients (50-75 years
old) with early and intermediate dry form of AMD were randomly assigned to two
groups, i.e. LA administration (n = 32) and placebo (n = 30) ... The apparent
increase in SOD activity caused by LA supplementation indicates that LA may have
a possible preventive effect in the development of AMD through an antioxidant
mechanism" - See
alpha lipoic acid at Amazon.com.
-
Nutrients Promote Eye
Health in Aging, Says Panel - Medscape, 4/17/12 -
"They pointed out that many multivitamin supplements do not contain nutrients
important for eye health, including lutein, zeaxanthin, and long-chain omega-3
fatty acids. "Taking a supplement specifically designed for eye health that
contains these key nutrients, in addition to a general nutritional supplement,
may therefore be a better approach to filling dietary shortfalls,""
-
Zeaxanthin Supplements as
Effective as Lutein in AMD - Medscape, 11/1/11 -
"Both lutein and zeaxanthin are carotenoids found in the
color pigment of the eye ... Using a visual test designed to identify early
signs of AMD, the researchers found that the vision in the zeaxanthin group
sharpened from 0.97 to 0.57 (P > 0.06, 1-tail)" - See
Jarrow Formulas, CarotenALL at Amazon.com.
-
Meta-analysis supports lutein’s eye health benefits - Nutra USA, 10/3/11 -
"The new meta-analysis pooled data from only six
longitudinal cohort studies. Crunching the numbers showed that the highest
intakes of lutein and zeaxanthin were not associated with a reduced risk of
early AMD ... On the other hand, the highest intake of these carotenoids was
associated with 26% reduction in the risk of late AMD, and a significant
reduction in the risk of neovascular AMD" - [Abstract]
- See
Jarrow Formulas, CarotenALL at Amazon.com.
-
Lutein and
zeaxanthin intake and the risk of age-related macular degeneration: a systematic
review and meta-analysis - Br J Nutr. 2011 Sep 8:1-10 -
"We conducted a systematic literature review and
meta-analysis to evaluate the relationship between dietary intake of lutein and
zeaxanthin and AMD risk. Relevant studies were identified by searching five
databases up to April 2010 ... The pooled relative risk (RR) for early AMD,
comparing the highest with the lowest category of lutein and zeaxanthin intake,
was 0.96 (95 % CI 0.78, 1.17). Dietary intake of these carotenoids was
significantly related with a reduction in risk of late AMD (RR 0.74; 95 % CI
0.57, 0.97); and a statistically significant inverse association was observed
between lutein and zeaxanthin intake and neovascular AMD risk (RR 0.68; 95 % CI
0.51, 0.92). The results were essentially consistent among subgroups stratified
by participant characteristics. The findings of the present meta-analysis
indicate that dietary lutein and zeaxanthin is not significantly associated with
a reduced risk of early AMD, whereas an increase in the intake of these
carotenoids may be protective against late AMD" - See
Jarrow Formulas, CarotenALL at Amazon.com.
-
High Antioxidant Intake May Lower Risk for Early AMD - Medscape, 6/14/11
- "We assessed the intake of antioxidants, zinc, and
ω-3 fatty acids in daily foods, diagnosed the onset of early AMD during a
lengthy follow-up, and investigated the risk-reducing effect of these
nutrients in the various genotypes of CFH [complement factor H] Y402H and
LOC387715 A69S ... Median follow-up duration was 8.6 years ... There
appeared to be a possible biological interaction between the CFH Y402H
genotype and intakes of zinc, β-carotene, lutein/zeaxanthin, and
eicosapentaenoic/docosahexaenoic acid (EPA/DHA), and between the LOC387715
A69S genotype and zinc and EPA/DHA, based on significant synergy indices ...
High dietary intake of nutrients with antioxidant properties reduces the
risk of early AMD in those at high genetic risk"
-
Vitamin D Protects Against Age-Related Vision Loss in Women - ABC News,
4/12/11 - "women who consume high levels of vitamin
D through certain fish, dairy, eggs, and leafy greens could lower the risk
of macular degeneration, the leading cause of vision loss in later life, by
59 percent" - [Nutra
USA] - See
vitamin D at Amazon.com.
-
Omega-3 fatty acid intake linked with reduced risk of age-related macular
degeneration in women - Science Daily, 3/14/11 -
"Brigham and Women's Hospital and Harvard Medical School, Boston, and
colleagues collected data on 38,022 women who had not been diagnosed with
age-related macular degeneration. Information on women's eating habits was
obtained via questionnaire at the beginning of the study and included
information on intake of docosahexaenoic acid (DHA) and eicosapentaenoic
acid (EPA) [Omega-3 fatty acids found in fish], and arachidonic acid and
linoleic acid (omega-6 fatty acids). During ten years of follow-up,
additional questionnaires tracked the women's eye health, with specific
focus on diagnosis of age-related macular degeneration ... women who
consumed the most DHA compared with women who consumed the lowest amount had
a 38 percent lower risk of developing age-related macular degeneration.
Similar results were observed for higher intake of EPA and for higher
consumption of both types of acid together ... consumption of one or more
servings of fish per week, when compared to less than one per month, was
associated with a 42 percent lower risk of age-related macular degeneration
... For omega-6 fatty acids, higher intake of linoleic acid but not
arachidonic acid was associated with an increased risk of age-related
macular degeneration, however this association was non-significant after
adjustment for other risk factors and fats" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
How
omega 3s help to prevent several forms of blindness - Science Daily,
2/9/11 - "The cost of omega-3 supplementation is
about $10 a month, versus up to $4,000 a month for anti-VEGF therapy ... In
the new study, they document another protective mechanism: a direct effect
on blood vessel growth (angiogenesis) that selectively promotes the growth
of healthy blood vessels and inhibits the growth of abnormal vessels ... In
addition, Smith and colleagues isolated the specific compound from omega-3
fatty acids that has these beneficial effects in mice (a metabolite of the
omega-3 fatty acid DHA, known as 4-HDHA), and the enzyme that produces it
(5-lipoxygenase, or 5-LOX). They showed that COX enzymes are not involved in
omega-3 breakdown, suggesting that aspirin and NSAIDs -- taken by millions
of Americans -- will not interfere with omega-3 benefits ... Finally, the
study demonstrated that 5-LOX acts by activating the PPAR-gamma receptor,
the same receptor targeted by "glitazone" drugs such as Avandia, taken by
patients with type 2 diabetes to increase their sensitivity to insulin.
Since these drugs also increase the risk for heart disease, boosting omega-3
intake through diet or supplements might be a safer way to improve insulin
sensitivity in patients with diabetes or pre-diabetes" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
New
evidence for eye-protective effects of omega-3-rich fish, shellfish -
Science Daily, 12/1/10 - "Our study corroborates
earlier findings that eating omega-3-rich fish and shellfish may protect
against advanced AMD" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Ingredient in red wine may prevent some blinding diseases - Science
Daily, 6/26/10 - "Resveratrol -- found in red wine,
grapes, blueberries, peanuts and other plants -- stops out-of-control blood
vessel growth in the eye ... There are three major eye diseases that
resveratrol treatment may help: age-related macular degeneration, diabetic
retinopathy and retinopathy of prematurity" - See
resveratrol products at Amazon.com.
-
Fruits, Leafy Greens Are Good for the Eyes - WebMD, 12/22/09 -
"These foods contain the carotenoids such as lutein
and zeaxanthin, which play an important role in vision and have a positive
impact on the retina ... Lutein and zeaxanthin may help reduce disability
and discomfort from glare, enhance contrast, and reduce photostress recovery
times ... about 600 carotenoids can be identified in nature ... Lutein and
zeaxanthin are found in kale and spinach, among other vegetables ... Of
about 20 carotenoids found in human blood, only lutein and zeaxanthin are
found in the visual system, the researchers write, suggesting these pigments
play a "special role" in human vision" - Great, I'll definitely stock
up on kale. That'd be as much fun as eating worms from my lawn. See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
-
Eat
Fruits and Vegetable for Better Vision - Science Daily, 12/18/09 -
"Carotenoids, found in green leafy vegetables and
colored fruits, have been found to increase visual performance and may
prevent age-related eye diseases ... macular pigments, such as lutein and
zeaxanthin do have an effect on visual performance. Lutein and zeaxanthin
can reduce disability and discomfort from glare, enhance contrast, and
reduce photostress recovery times. They can also reduce glare from light
absorption and increase the visual range"
-
Egg Yolks May Reduce Risk of Age-Related Macular Degeneration -
Medscape, 11/13/09 - "Two eggs per day is probably
all that is needed to maximize blood levels of lutein and zeaxanthin as well
as macular pigment optic density (MPOD) status"
-
Omega-3 may prevent age-related sight loss - Nutra USA, 10/8/09 -
"a meta-analysis published in the June 2008 issue of
the Archives of Ophthalmology found that a high intake of omega-3 fatty
acids and fish may reduce the risk of AMD by up to 38 per cent ... Over 12
years of study, the researchers found that intakes of omega-3, estimated
using a food-frequency questionnaire, were related to both wet and dry AMD
risk ... Indeed, participants with the highest omega-3 intakes, equivalent
to about 0.11 per cent of their total energy intakes, had a 30 per cent
lower risk of developing both types than people with the lowest intakes"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
{omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of
neovascular age-related macular degeneration and central geographic atrophy:
a prospective cohort study from the Age-Related Eye Disease Study - Am J
Clin Nutr. 2009 Oct 7 - "Participants who reported
the highest omega-3 LCPUFA intake (median: 0.11% of total energy intake)
were 30% less likely than their peers to develop CGA and NV AMD. The
respective odds ratios were 0.65 (95% CI: 0.45, 0.92; P </= 0.02) and 0.68
(95% CI: 0.49, 0.94; P </= 0.02)" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Omega-3 may prevent blindness in the elderly: Study - Nutra USA, 7/23/09
- "A diet high in omega-3 fatty acids may prevent
the development of age-related macular degeneration (AMD) ... mice fed a
high omega-3 fatty acid diet displayed a slower development of lesions in
their retina, compared to animals fed a low omega-3 diet. Furthermore, some
of the mice in the omega-3 group displayed some reversion of the lesions"
- [Abstract] - [Science
Daily] - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
A High Omega-3 Fatty
Acid Diet Reduces Retinal Lesions in a Murine Model of Macular Degeneration
- Am J Pathol. 2009 Jul 16 - "Ccl2(-/-)/Cx3cr1(-/-)
mice that ingested a high n-3 fatty acid diet showed a slower progression of
retinal lesions compared with the low n-3 fatty acids group. Some mice that
were given high levels of n-3 fatty acids had lesion reversion" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
New
Supplement May Help Slow Sight Loss In Elderly - Science Daily, 6/19/09
- "As the macula of the eye is very rich in
antioxidants the researchers wanted to see if a supplement called CARMA
(Caroteneoids and Co-antioxidants in Age-related Maculopathy) containing the
carotenoids lutein and zeaxanthin could help slow down AMD ... The
supplement also contained vitamins C,E and Zinc"
-
Omega-3 Fatty Acids May Protect Against Progression Of Age-related Macular
Degeneration - Science Daily, 6/18/09 - "we
observed participants with early stages of AMD in the placebo group
benefited from higher intake of DHA, but it appears that the high-dose
supplements of the antioxidants and/or the minerals somehow interfered with
the benefits of DHA against early AMD progression ... The antioxidant
supplements did not seem to interfere with the protective effects of DHA and
EPA against progression to advanced stages of AMD. Participants who consumed
higher amounts of DHA and EPA appeared to have lower risk of progression to
both wet and dry forms of advanced AMD"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Omega-3 plus AREDS supplement works for eye health: Study - Nutra USA,
6/16/09 - "Increased intake of DHA was associated
with a 27 per cent reduction in the progression to advanced age-related
macular degeneration (AMD), while EPA was linked to a 26 per cent reduction"
- [Abstract] - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Does eating particular
diets alter risk of age-related macular degeneration in users of the
age-related eye disease study supplements? - Br J Ophthalmol. 2009 Jun
12 - "Independent of AREDS supplementation, higher
intakes of DHA (>/= 64.0 vs. < 26.0 mg/d) (hazard ratio [HR] = 0.73, 95%
confidence interval [CI], 0.57, 0.94), EPA (>/= 42.3 vs. < 12.7 mg/d) (HR =
0.74, 95% CI, 0.59, 0.94), and lower dGI (dGI, < 75.2 vs. >/= 81.5) (HR =
0.76, 95% CI, 0.60, 0.96) were associated with lower risk for progression to
advanced AMD. Participants consuming lower dGI and higher DHA or EPA had the
lowest risk (P for synergistic interaction < 0.001) ... Our findings show an
association of consuming a diet rich in DHA with lower progression of early
AMD" - See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Eating Fish, Nuts And Olive Oil May Be Associated With Reduced Risk Of
Age-related Blindness - Science Daily, 5/15/09 -
"Individuals who consumed higher levels of trans-unsaturated fats—found in
baked goods and processed foods—were more likely to have late AMD, whereas
those who consumed the most omega-three fatty acids were less likely to have
early AMD. "Olive oil intake (100 milliliters or more per week vs. less than
1 milliliter per week) was associated with decreased prevalence of late
AMD," the authors write. "No significant associations with AMD were observed
for intakes of fish, total fat, butter or margarine.""
-
Dietary
fatty acids and the 10-year incidence of age-related macular degeneration:
the Blue Mountains Eye Study - Arch Ophthalmol. 2009 May;127(5):656-65 -
"1 serving of fish per week was associated with
reduced risk of incident early AMD (relative risk, 0.69 [95% confidence
interval, 0.49-0.98]), primarily among participants with less than the
median linoleic acid consumption (0.57 [0.36-0.89]). Findings were similar
for intake of long-chain omega-3 polyunsaturated fatty acids. One to 2
servings of nuts per week was associated with reduced risk of incident early
AMD (relative risk, 0.65 [95% confidence interval, 0.47-0.91])"
-
Fat
consumption and its association with age-related macular degeneration -
Arch Ophthalmol. 2009 May;127(5):674-80 - "Higher
trans-unsaturated fat intake was associated with an increased prevalence of
late AMD; the odds ratio comparing the highest with the lowest quartile of
trans fat was 1.76 (95% confidence interval, 0.92-3.37; P = .02). Higher
omega-3 fatty acid intake (highest quartile vs lowest quartile) was
inversely associated with early AMD (odds ratio, 0.85; 95% confidence
interval, 0.71-1.02; P = .03). Olive oil intake (> or =100 mL/week vs <1
mL/week) was associated with decreased prevalence of late AMD (odds ratio,
0.48; 95% confidence interval, 0.22-1.04; P = .03). No significant
associations with AMD were observed for intakes of fish, total fat, butter,
or margarine"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Lutein, Zeaxanthin
Supplements May Result in Better Macular Function in Early AMD -
Medscape, 5/13/09 - "Although no statistically
significant difference was seen in best corrected distance visual acuity (BC
DVA) at 12 months, oral supplementation with lutein and zeaxanthin with
coantioxidants may improve functional and morphologic outcomes at 36 months
in patients at high risk for progression to late age-related macular
degeneration (AMD) ... Results at 36 Months Significant" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
-
Mediterranean Diet May Boost Eye Health - WebMD, 5/11/09 -
"people who ate one serving of fish per week had a
31% lower risk of early signs of AMD. Those who ate one to two servings of
nuts rich in omega-3 fatty acids had a 35% lower risk"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Can B Vitamins Lower Risk of Blindness? - WebMD, 2/23/09 -
"researchers randomly assigned more than 5,000 women
over 40 without signs of age-related macular degeneration to take a
combination of 2.5 milligrams of folic acid, 50 milligrams of vitamin B6,
and one milligram of vitamin B12 or a placebo every day ... The results
showed that women taking the B vitamin supplements had a 34% lower risk of
any AMD and a 41% lower risk of AMD with vision loss than the placebo group
... the benefits of the vitamin Combination in preventing AMD appeared to
emerge about two years after treatment began"
-
Dietary
glycemic index and the risk of age-related macular degeneration - Am J
Clin Nutr. 2008 Oct;88(4):1104-10 - "a higher mean
dietary glycemic index was associated with an increased 10-y risk of early
AMD in a comparison of quartiles 1 and 4 [relative risk (RR): 1.77; 95% CI:
1.13, 2.78; P for trend = 0.03]. Conversely, a greater consumption of cereal
fiber (RR: 0.68; 95% CI: 0.44, 1.04; P for trend = 0.05) and breads and
cereals (predominantly lower glycemic index foods such as oatmeal) (RR:
0.67; 95% CI: 0.44, 1.02; P for trend = 0.03) was associated with a reduced
risk of incident early AMD ... A high-glycemic-index diet is a risk factor
for early AMD-the recognized precursor of sight-threatening late AMD.
Low-glycemic-index foods such as oatmeal may protect against early AMD"
-
Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic
acid intakes, and associations with neovascular age-related macular
degeneration - Am J Clin Nutr. 2008 Aug;88(2):398-406 -
"neovascular AMD (NV-AMD) ... Eating oily fish at
least once per week compared with less than once per week was associated
with a halving of the OR for NV-AMD"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Eat
Oily Fish At Least Once A Week To Protect Your Eyesight In Old Age -
Science Daily, 8/8/08 - "people who habitually
consume oily fish at least once a week compared with less than once a week
are 50% less likely to have wet AMD. There was no benefit from consumption
of non oily white fish. There was a strong inverse association between
levels of DHA and EPA and wet AMD. People in the top 25% of DHA and EPA
levels (300 mg per day and above) were 70% less likely to have wet AMD"
- See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Eating Fish And Foods With Omega-3 Fatty Acids Linked To Lower Risk Of
Age-related Eye Disease - Science Daily, 6/9/08 -
"When results from all nine studies were combined, a
high dietary intake of omega-3 fatty acids was associated with a 38 percent
reduction in the risk of late (more advanced) AMD, while eating fish twice a
week was associated with a reduced risk of both early and late AMD ...
"Long-chain omega-3 fatty acids, docosahexaenoic acid in particular, form an
integral part of the neural retina," the layer of nerve cells in the retina"
- See
Mega Twin EPA at Amazon.com
or
Jarrow Max DHA at Amazon.com.
-
Lutein, zeaxanthin for AMD protection: more science - Nutra USA, 3/13/08
- "people with the highest average intakes of
dietary lutein and zeaxanthin had a 65 per cent reduced risk of neo-vascular
AMD than those with the lowest average intakes" - [Abstract]
- See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
-
Dietary carbohydrate and the progression of age-related macular
degeneration: a prospective study from the Age-Related Eye Disease Study
- Am J Clin Nutr. 2007 Oct;86(4):1210-1218 - "The
latter gives an estimate that 7.8% of new advanced AMD cases would be
prevented in 5 y if people consumed the low-dGI diet"
-
Limiting Refined Carbohydrates May Stall AMD Progression - Science
Daily, 10/8/07 - "Our data showed those people in
the high-glycemic-index group were at greater risk of AMD progression,
especially those already in the late stages ... Participants who consumed
the most refined carbohydrates were 17 percent more likely to develop
blinding AMD than the group that consumed the least"
-
Nutrients May Help Save Eyes - WebMD, 9/11/07 -
"Those with the highest self-reported intake of foods rich in lutein and
zeaxanthin were 35% less likely than those with the lowest lutein and
zeaxanthin intake to have "wet" age-related macular degeneration"
-
Certain Nutrients Associated With Reduced Risk For Age-related Eye Disease
- Science Daily, 9/10/07 - "If these cross-sectional
results can be confirmed in prospective samples and experimental studies,
lutein and zeaxanthin may be considered as useful agents in food or
supplement-based interventions designed to reduce the risk of AMD"
-
Zinc
Linked To Macular Degeneration, Study Suggests - Science Daily, 8/27/07
- "In studying eye tissue samples, the researches
found that deposits, that are hallmarks of age-related macular degeneration
(AMD), contain large amounts of zinc ... The double-edged sword is that zinc
has been found to enhance the immune system, but also could play a role in
the advancement of macular degeneration"
-
High-Sugar Foods May Affect Eyesight - WebMD, 7/13/07 -
"People with the diets highest on the glycemic index
were the most likely to have advanced AMD in at least one eye"
-
Link
Between Carbohydrate Quality And Vision Loss Is Strengthened By New Data
- Science Daily, 7/11/07 - "the risk for AMD may be
diminished by improving dietary carbohydrate quality, as defined by dietary
glycemic index. This may be achieved by relatively simple dietary
alterations, such as replacing white bread with whole grain bread"
-
Association between dietary glycemic index and age-related macular
degeneration in nondiabetic participants in the Age-Related Eye Disease
Study - Am J Clin Nutr. 2007 Jul;86(1):180-8 -
"Compared with eyes in the first quintile of dGI, eyes in the fourth and
fifth quintiles had a significantly or suggestively higher risk of large
drusen, geographic atrophy, and neovascularization. The
multivariate-adjusted odds ratios (95% CIs) for the highest quintile were
1.42 (1.09, 1.84), 1.78 (0.81, 3.90), and 1.41 (0.95, 2.08), respectively,
of which only the odds ratio for large drusen was significant. A significant
positive relation between dGI and severity of AMD was also noted (P for
trend < 0.001). There was a 49% increase in the risk of advanced AMD
(geographic atrophy plus neovascularization) for persons with a dGI higher
than the sex median"
-
Association Between Vitamin D and Age-Related Macular Degeneration in the
Third National Health and Nutrition Examination Survey, 1988 Through 1994
- Arch Ophthalmol. 2007 May;125(5):661-669 - "The
odds ratio (OR) and 95% confidence interval (CI) for early AMD among
participants in the highest vs lowest quintile of serum vitamin D was 0.64
... This study provides evidence that vitamin D may protect against AMD"
- See
vitamin D at Amazon.com.
-
Eating Fish May Preserve Eyesight - WebMD, 5/15/07
-
Higher Intake Of Fish And Vitamin D Levels Linked To Lower Risk Of
Age-related Macular Disease - Science Daily, 5/14/07 -
"Individuals who have higher dietary intake of foods
with omega-3 fatty acids and higher fish consumption have a reduced risk of
advanced age-related macular degeneration, while those with higher serum
levels of vitamin D may have a reduced risk of the early stages of the
disease" - See
Jarrow Max DHA at Amazon.com
and
vitamin D at Amazon.com.
-
High Dose Vitamins May Boost Macular Health - Doctor's Guide, 11/16/06 -
"A small study of high-dose dietary supplementation
with betacarotene, vitamin C, vitamin E, zinc, copper, lutein, and
zeaxanthin shows that a potential way to improve macular health in patients
with dry age-related macular degeneration"
-
Low-Glycemic-Index Diet Slows AMD Progression - Medscape, 5/8/07 -
"age-related macular degeneration (AMD) ...
consumption of highly refined carbohydrates can lead to up to a 17%
increased risk of AMD progression"
-
Predictors of optical density of lutein and zeaxanthin in retinas of older
women in the Carotenoids in Age-Related Eye Disease Study, an ancillary
study of the Women's Health Initiative - Am J Clin Nutr. 2006
Nov;84(5):1107-22 - "Macular pigment optical density
(MPOD) was measured by heterochromatic flicker photometry ... MPOD is
directly related to dietary intake of lutein and zeaxanthin but even more
strongly to serum concentrations, which may reflect unmeasured physical and
medical factors that influence the uptake, distribution, and utilization of
lutein and zeaxanthin. Higher abdominal body fat and diabetes are related to
lower MPOD"
-
Exercise May Help
Protect Against Age-Related Macular Degeneration - Medscape, 11/7/06 -
"An active lifestyle reduced the risk for incident exudative AMD by 70% ...
Increased walking of more than 12 blocks daily decreased the incidence of
exudative AMD by 30% over 15 years"
-
Protection for Aging Eyes - New Hope Natural Media Online, 8/31/06 -
"A 40% reduction in the incidence of early
age-related macular degeneration was associated with eating fish at least
once a week; eating fish at least three times per week even reduced the
incidence of late-stage age-related macular degeneration"
-
Associations between intermediate age-related macular degeneration and
lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study
(CAREDS): ancillary study of the Women's Health Initiative - Arch
Ophthalmol. 2006 Aug;124(8):1151-62 - "Diets rich in
lutein plus zeaxanthin may protect against intermediate AMD in healthy women
younger than 75 years"
-
Fish Oil May Help Save Your Eyes - WebMD, 7/10/06 -
"men with the highest fish consumption (at least two
weekly servings) were 45% less likely to have AMD than those with the lowest
fish consumption (less than one weekly serving)"
-
Dietary Fatty acids and the 5-year incidence of age-related maculopathy
- Arch Ophthalmol. 2006 Jul;124(7):981-6 - "A 40%
reduction of incident early ARM was associated with fish consumption at
least once a week (odds ratio [95% confidence interval], 0.58 [0.37-0.90]),
whereas fish consumption at least 3 times per week could reduce the
incidence of late ARM (odds ratio [95% confidence interval], 0.25
[0.06-1.00]). We found no association between incident ARM and butter,
margarine, or nut consumption"
-
Loss of Central Vision with Age May Be Linked to Quality of Dietary
Carbohydrates - Doctor's Guide, 6/6/06 -
"Women who consumed diets with a relatively high
dietary glycemic index had greater risk of developing signs of early
age-related macular degeneration when compared with women who consumed diets
with a lower dietary glycemic index"
-
High Glycemic Index
Diet May Increase Risk of Developing AMD - Medscape, 4/18/06 -
"The age-adjusted model showed more than a 2-fold increase in risk for ARM
for the third tertile of dietary GI"
-
Diet, Lifestyle
May Affect Eye Health - WebMD, 3/24/06 -
"Eating healthfully, not smoking, and not being
overweight could help keep age-related macular degeneration at bay"
-
Dietary intake of antioxidants and risk of age-related macular degeneration
- JAMA. 2005 Dec 28;294(24):3101-7 - "In this study,
a high dietary intake of beta carotene, vitamins C and E, and zinc was
associated with a substantially reduced risk of AMD in elderly persons"
-
Healthy Diet May Help
Seniors' Vision - WebMD, 12/27/05 -
"People with above-average intakes of all four
antioxidants were 35% less likely to develop AMD during the study ... Vitamin E
and zinc stood out"
-
Antioxidants Reduce Visual Acuity Loss in Patients with Advanced Age-Related
Macular Degeneration - Doctor's Guide, 10/26/05 -
"The high-dose formulation has been shown to have
beneficial effects in reducing by 25% the risk of advanced AMD ... The first
group received three antioxidant vitamins: vitamin C 500 mg, vitamin E 400 IU,
and beta carotene 15 mg. Group two received zinc oxide 80 mg, plus cupric acid 2
mg. The third group received the antioxidant vitamins plus the zinc and cupric
oxide"
-
AREDS II to Answer Questions Raised by AREDS - Doctor's Guide, 10/26/05
- "Lutein and omega-3 "are of particular interest
because of the mounting epidemiologic data that suggests that nutrients are
associated with a decreased risk of AMD"
-
Plasma homocysteine, vitamin B12 and folate levels in age-related macular
degeneration - Graefes Arch Clin Exp Ophthalmol. 2005 Sep 15;:1-5 -
"Patients with both exudative and dry types of AMD
had significantly higher plasma homocysteine levels ... Plasma vitamin B12
levels were found to be significantly lower in the exudative AMD group"
-
Innovative Research and Applications for CoQ10 - Life Extension
Magazine, 8/04 -
"biomedical researchers are discovering that
CoQ10
shows promising effects against disorders as far-ranging as kidney failure,
heart disease, muscular dystrophy, and macular degeneration"
- Broccoli May
Prevent Blindness - WebMD, 7/13/04 -
"sulforaphane, the naturally occurring antioxidant
in broccoli and broccoli sprouts, protects the eye from damage caused by the
sun's ultraviolet light"
- Fruit May Help
Prevent Macular Degeneration - WebMD, 6/14/04 -
"people who ate three or more servings per day of
fruits had a 36% lower risk of age-related macular degeneration (ARM)
compared those who ate less than one-and-a-half servings per day"
- Lutein Improves
Visual Function in Age-Related Macular Degeneration - Medscape, 4/8/04 -
"Snellen equivalent visual acuity improved 5.4
letters in the lutein-only group and 3.5 letters in the lutein/antioxidant
group. The lutein-only group also had a net subjective improvement in Amsler
grid, and the lutein/antioxidant group had a nearly significant improvement
in subjective glare recovery" - See
lutein at Amazon.com.
- Fish Oil
Benefits Your Eyes - WebMD, 5/8/03 -
"Why might fish oil
protect eyes from age-related macular degeneration? One component of fish
oil is docosahexaenoic acid -- DHA
for short. It's one of the omega-3 fatty acids linked to other health
benefits. Interestingly, DHA builds up in the eye near light-sensing nerve
cells"
- Dietary Omega-3 Fatty
Acids May Reduce Risk of AMD - Medscape, 5/6/03 -
"Dietary omega-3
fatty acids but not beta-carotene supplementation is associated with a
reduced risk of age-related macular degeneration (AMD) ... omega-3 fatty
acids may also reduce the risk of dry eye syndrome
in women" - See Mega Twin EPA at Amazon.com
- Lutein Holds
Promise for Cataract Sufferers - Health Supplement Retailer, 12/30/02 -
"gave 17 cataract patients 15 mg of
lutein (as 12 mg of all-trans-lutein and 3
mg of 13/15-cis-lutein present as mixed lutein esters) or 100 mg of
vitamin E (as alpha-tocopherol) or a placebo three times per week for up
to two years ... The lutein group also experienced improved visual acuity
and glare sensitivity, while the vitamin group was found to experience only
a maintenance in visual acuity and the placebo group a decrease" -
Click here for the actual study. See
lutein at Amazon.com.
- Harvard Study
Shows Zeaxanthin Good for AMD - Health Supplement Retailer, 11/11/02 -
"Our studies showed that light damage was strongly
influenced by the amount of
zeaxanthin
in the retina, and that significantly greater retinal protection was
provided at dietary levels higher than those normally occurring in the diet"
-
Macular Degeneration Epidemic - Life Extension Magazine, 5/02 -
"AMD patients who have begun taking high-dose
lutein
supplements (4 mg or more per day) appear to return to 'normal' levels after
a few months. These findings are consistent with the hypothesis that a
long-term deficiency of macular carotenoids may be associated with higher
risk of AMD"
- Zinc,
Antioxidants Prevent Some Forms of Vision Loss - WebMD, 10/12/01 -
"people at risk of losing more sight due to a
condition called "age-related macular degeneration" (AMD) could prevent
further vision loss by taking a combination of zinc and antioxidants,
including vitamins C and E and beta-carotene ... The antioxidants were taken
once a day at a dose of 500 mg of vitamin C, 400 IU of vitamin E, and 15 mg
of beta-carotene. Zinc was given as 80 mg of zinc oxide along with 2 mg of
copper in the form of cupric oxide to prevent anemia, which can occur from
too much zinc ... the high levels of dietary supplements that were taken in
this study are very difficult to achieve from diet alone"
-
Vitamin Regimen Can Prevent Blindness - Intelihealth, 10/12/01 -
"High doses of antioxidant vitamins plus the mineral
zinc can slow or even prevent vision loss in people
with macular degeneration ... for those with intermediate disease, a daily
vitamin supplement plus 80 milligrams of zinc reduced the risk of developing
advanced disease by about 25 percent compared with a placebo ... Patients
received 500 milligrams of vitamin C per day,
along with 400 international units of vitamin E
and 15 milligrams of beta-carotene ... High
doses of zinc can cause anemia, but participants also took 2 milligrams of
copper daily to counter that effect"
-
Study: Snacks May be Bad for Vision - Intelihealth, 8/15/01 -
"Overindulging in fat-filled snack foods may
heighten the risk of developing advanced age-related macular degeneration,
the leading cause of blindness and vision impairment in the United States
for those over 55 ... The foods that contain these fats are highly
processed, store-bought junk foods. Included in the study: margarine,
chocolate, commercially prepared pie, cake, cookies, peanut butter, potato
chips, french fries and nuts ... The study found that diets high in omega-3
fatty acids, found primarily in albacore tuna and salmon, could lessen the
risk for age-related macular degeneration, as long as fish eaters maintain a
low intake of linoleic acid (found in processed food and margarine)."
Other News:
-
Three Eye Conditions
Linked to Higher Alzheimer's Risk - Medscape, 8/14/18 -
"Participants recently diagnosed with glaucoma had a 46%
increased likelihood of developing AD. Similarly, the risk among those recently
diagnosed with AMD or diabetic retinopathy had a 50% increased AD risk compared
with their counterparts without these conditions"
-
Regular aspirin use linked to increased risk of age-related macular
degeneration - Science Daily, 1/21/13 -
"age-related macular degeneration (AMD), which is a leading cause of
blindness in older people ... The cumulative incidence of neovascular AMD
among nonregular aspirin users was 0.8 percent at five years, 1.6 percent at
10 years, and 3.7 percent at 15 years; among regular aspirin users, the
cumulative incidence was 1.9 percent at five years, 7 percent at 10 years
and 9.3 percent at 15 years, respectively ... Regular aspirin use was
significantly associated with an increased incidence of neovascular AMD"
-
AMD-like lesions delayed in mice fed lower glycemic index diet - Science
Daily, 11/14/11 - "The dietary glycemic index (DGI)
measures the rate at which glucose is delivered to the bloodstream after
consuming carbohydrates. Higher GI foods including white bread and white
potatoes trigger a rapid delivery of glucose that pushes the body to work
overtime to absorb, whereas lower GI foods, like whole grain bread and
fruits and vegetables, initiate a slower release of glucose that is more
easily processed by cells ... Compared to the mice on the lower GI diet,
mice on the higher GI diet demonstrated elevated accumulations of debris
known as advanced glycation end products (AGEs) in the whole retina,
particularly in the cells of the RPE. The RPE plays a crucial role in
maintaining vision and its dysfunction results in the gradual central vision
loss that is the hallmark of AMD. AGE accumulation has also been linked to
tissue damage in other age-related diseases such as Type 2 diabetes and
cardiovascular disease"
-
Aspirin Use Linked to Aging Macula Disorder in Older Individuals -
Medscape, 5/4/10 - "People 65 years and older who
frequently take aspirin have an increased risk of developing aging macula
disorder — a loss of central vision similar to age-related macular
degeneration — according to a population-based ... the odds ratios for grade
1 early aging macula disorder rose with increasing aspirin intake frequency,
and reached 1.26 (95% confidence interval [CI]. 1.08 - 1.46; P trend < .001)
for subjects who reported daily use ... Similarly, the odds ratio for grade
2 early aging macula disorder was 1.40 (95% CI, 1.16 - 1.68; P trend < .001)
in daily aspirin users; for neovascular aging macula disorder, the odds
ratio was 2.26 (95% CI, 1.66 - 3.08; P trend < .001) in daily aspirin users"
-
How
Diet, Antioxidants Prevent Blindness In Aging Population - Science
Daily, 8/25/08 - "They found antioxidants disrupt
the link and extend the lifetime of irreplaceable photoreceptors and other
retinal cells ... The implication is that people at risk of macular
degeneration could help prevent the disease by consuming antioxidants ...
The experiments performed with visual cells from rats, cows and humans
showed that antioxidants could completely counter the damage"
-
Hormone Therapy May Cut Risk of AMD - WebMD, 4/14/08 -
"Current hormone users were found to have a 48%
lower risk for developing the neovascular, or wet, form of AMD, compared
with women who had never taken postmenopausal hormones"
-
Inflammation Linked to Eye Disease - WebMD, 10/8/07 -
"participants with the highest CRP levels at the
study's start were 40% more likely to develop early-stage AMD during the
study, compared to those with the lowest initial CRP levels"
-
Biomarker For Age-related Macular Degeneration Found - Science Daily,
1/8/06 - "elevated homocysteine in the blood may be
another biomarker for increased risk of AMD"
-
Passive Smoking Almost Doubles Risk Of Degenerative Eye Disease -
Science Daily, 1/3/06 - "Passive smoking almost
doubles the risk of the progressively degenerative eye disease, age related
macular degeneration"
-
Excess Body Fat May Elevate Risk for Age-Related Eye Diseases - Doctor's
Guide, 9/14/05 - "excess body fat may elevate one's
risk for age-related eye diseases such as macular degeneration (AMD) and
cataracts ... if the body has too much adipose tissue, too much lutein and
zeaxanthin remain there in storage and do not get to the eye where they are
needed"
-
Statins for Blindness? - Time Magazine, 4/26/04 -
"The more serious, wet form occurs when abnormal
blood vessels obscure vision ... those who were taking statins were half as
likely to develop wet AMD"
-
Statins and Aspirin May Protect Against Severe Vision Loss in Elderly -
Doctor's Guide, 4/13/04 -
"those patients already taking statins were half as
likely as those without statins to develop the more severe wet AMD, caused
by the growth of new blood vessels underneath the retina. Those already on
aspirin were about 40 percent less likely to develop this new blood vessel
growth, technically called choroidal neovascularization"
-
High C-Reactive Protein Levels Associated with Increased Risk of Age-Related
Macular Degeneration - Doctor's Guide, 2/13/04 -
"CRP levels were significantly higher among
individuals with intermediate and advanced stages of AMD compared with
controls"
- Fat Intake Modifies
Progression of Age-Related Macular Degeneration - Medscape, 12/8/03 -
"Most types of dietary fat are associated with
increased risk of progression to advanced age-related macular degeneration
(AMD), whereas nuts and fish are protective ... Specifically, higher intake
of vegetable fat, and to a lesser extent animal fat, increased rates of
progression"
-
Inflammation Linked to Age-Related Maculopathy - Doctor's Guide, 6/11/03
-
"2 physiological signs of systemic
inflammation, high white blood cell (WBC) count and low serum albumin
levels, were associated with long term incidence of lesions characteristic
of ARM ... Specifically, higher WBC count at baseline was linked to 2 early
signs of ARM, an increase in large retinal drusen and RPE depigmentation, as
well as progression of ARM. Lower serum albumin was associated with a late
sign of ARM, exudative macular degeneration" - See my
inflammation page for ways to reduce it.
-
Retinal Abnormalities Age-Related Macular Degeneration Associated With
Hypertension, Pulse Pressure - Doctor's Guide, 4/10/03 -
"Retinal abnormalities in older people without
diabetes are related to hypertension. Higher
blood and pulse pressure are also
associated with an increased incidence of macular abnormalities, including
wet and dry
age-related macular degeneration (AMD)"
- HRT May Save
Women's Sight - WebMD, 12/13/02 -
"Women who take hormone
replacement therapy
(HRT) may be more than 50% less likely to develop the common, sight-robbing
condition known as macular degeneration as they grow older then women who
have never used HRT"
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