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Home > Health Conditions > Glaucoma.


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  • Combined use of coenzyme Q10 and citicoline: A new possibility for patients with glaucoma - Front Med (Lausanne) 2022 Dec 15 - "Glaucoma is the leading cause of irreversible blindness worldwide. Several risk factors have been involved in the pathogenesis of the disease. By now, the main treatable risk factor is elevated intraocular pressure. Nevertheless, some patients, whose intraocular pressure is considered in the target level, still experience a progression of the disease. Glaucoma is a form of multifactorial ocular neurodegeneration with complex etiology, pathogenesis, and pathology. New evidence strongly suggests brain involvement in all aspects of this disease. This hypothesis and the need to prevent glaucomatous progression led to a growing interest in the pharmacological research of new neuroprotective, non-IOP-lowering, agents. The aim of this paper is to report evidence of the usefulness of Coenzyme Q10 and Citicoline, eventually combined, in the prevention of glaucomatous neurodegeneration ... Overall, these data suggest the possible usefulness of the combined use of citicoline and CoQ10 both in terms of a putative synergistic effect and in terms of combined action on the different pathogenetic targets causing the onset and progression of glaucoma. Using combined treatment may downregulate more pro-apoptotic pathways as well as it may boost the effect on one or more pathways on which the different molecules act. In addition, it may increase patients’ compliance reducing the burden of administering several medications, simplifying treatment" - See ubiquinol products at Amazon.com and citicholine at Amazon.com.
  • Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma - Nutrients 2020 Oct 16 - "Vitamins ... Vitamin A ... Vitamin B Complex ... Vitamin C ... Vitamin D ... PUFAs ... Palmitoylethanolamide ... Melatonin ... Citicoline ... Coenzyme Q10 ... Taurine ... Resveratrol ... Forskolin ... Curcumin ... Lycium barbarum ... Saffron ... Erigeron breviscapus"
  • Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial - Clin Exp Ophthalmol 2020 Jul 28 - "Participants received oral placebo or nicotinamide and reviewed six-weekly. Participants commenced 6 weeks of 1.5 g/day then 6 weeks of 3.0 g/day followed by crossover without washout ... photopic negative response (PhNR) parameters: saturated PhNR amplitude (Vmax), ratio of PhNR/b-wave amplitude (Vmax ratio) ... PhNR Vmax improved beyond 95% coefficient of repeatability in 23% of participants following nicotinamide vs 9% on placebo. Overall, Vmax improved by 14.8% [95% CI: 2.8%, 26.9%], (P = .02) on nicotinamide and 5.2% [-4.2%, 14.6%], (P = .27) on placebo. Vmax ratio improved by 12.6% [5.0%, 20.2%], (P = .002) following nicotinamide, 3.6% [-3.4%, 10.5%], (P = .30) on placebo. A trend for improved visual field mean deviation was observed with 27% improving ≥1 dB on nicotinamide and fewer deteriorating (4%) compared to placebo" - [Nutra USA] - See nicotinamide at Amazon.com.
  • Effect of palmitoylethanolamide on inner retinal function in glaucoma: a randomized, single blind, crossover, clinical trial by pattern-electroretinogram - Sci Rep 2020 Jun 26 - "Glaucoma is a neurodegenerative disease, our study aimed to evaluate the potential effects of Palmitoylethanolamide (PEA) supplementation on RGCs function by PERG examination, and to record effects on intraocular pressure, visual field and quality of life ... At baseline, most patients had an early visual field defect, the IOP was well controlled. At the end of the PEA 600 mg supplementation, a significantly higher (mean 0.56 μV, 95% CI 0.30-0.73, p < 0.001) in the P50-wave amplitude was observed; in the PEA period a significantly lower IOP (- 1.6 mmHg, 95% CI - 2 to 1.2, p < 0.001) and higher quality of life scores (+ 6.7, 95% CI 4-9.9, p < 0.001) were observed. Our study is the first to show promising effects of PEA on PERG and on quality of life in glaucoma patients"
  • Turmeric-derived eye drops could treat glaucoma: study - Science Daily, 7/24/18 - "The research team found the eye drops can reduce the loss of retinal cells in rats, which is known to be an early sign of glaucoma ... Curcumin is an exciting compound that has shown promise at detecting and treating the neurodegeneration implicated in numerous eye and brain conditions from glaucoma to Alzheimer's disease, so being able to administer it easily in eye drops may end up helping millions of people ... After twice-daily use of eye drops in the rats for three weeks, retinal ganglion cell loss was significantly reduced compared to matched controls, and the treatment was found to be well-tolerated with no signs of eye irritation or inflammation"
  • Oral Omega-3 Supplementation Lowers Intraocular Pressure in Normotensive Adults - Transl Vis Sci Technol. 2018 May 1;7(3):1 - "These findings justify further investigation into the therapeutic potential of omega-3 supplementation for reducing IOP, to prevent and/or treat conditions with IOP elevation, including ocular hypertension and glaucoma" - [Nutra USA] - See omega-3 supplements at Amazon.com.
  • Vitamin B3 prevents glaucoma in laboratory mice - Science Daily, 2/16/17 - "In mice genetically predisposed to glaucoma, vitamin B3 added to drinking water is effective at preventing the disease ... The vitamin administration was surprisingly effective, eliminating the vast majority of age-related molecular changes and providing a remarkably robust protection against glaucoma. It offers promise for developing inexpensive and safe treatments for glaucoma patients" - See vitamin B3 at Amazon.com.
  • Use of Topical Cannabinomimetic Palmitoylethanolamide in Ocular Surface Disease Associated with Antiglaucoma Medications - J Ocul Pharmacol Ther 2017 Nov - "Chronic use of topical hypotensive therapies in glaucoma patients leads to chronic inflammation of the ocular surface, which decreases the success rate of long-term glaucoma management. The aim of this study is to evaluate the effect of topical palmitoylethanolamide (PEA) (Defluxa©), a well-known anti-inflammatory and analgesic agent, in suppressing the ocular surface inflammation associated with the use of hypotensive eye drops ... Compared to control, by day 15, the conjunctival hyperemia score was significantly decreased in the PEA (Defluxa) group (P < 0.01), while the T-BUT and the Schirmer Test achieved a significant improvement by day 30"
  • Metformin use associated with reduced risk of developing open-angle glaucoma - Science Daily, 5/28/15 - "patients prescribed the highest amount of metformin (greater than 1,110 grams in two years) had a 25 percent reduced risk of OAG risk compared with those who took no metformin. Every one-gram increase in metformin was associated with a 0.16 percent reduction in OAG risk, which means that taking a standard dose of 2 grams of metformin per day for two years would result in a 20.8 percent reduction in risk of OAG ... this study points out the importance of understanding the potential impact of CR (caloric restriction) mimetic drugs on the risk of developing other medical conditions that affect older persons"
  • Effect of palmitoylethanolamide on visual field damage progression in normal tension glaucoma patients: results of an open-label six-month follow-up - J Med Food 2014 Sep;17 - "The purpose of this study is to assess the effect of palmitoylethanolamide (PEA) oral administration on intraocular pressure (IOP) and visual field damage progression in normal-tension glaucoma (NTG) patients ... Visual field parameters significantly diminished in patients receiving PEA compared to baseline values (-7.65±6.55 dB vs. -4.55±5.31 dB, p<0.001; 5.21±4.08 dB vs. 3.81±3.02 dB ... systemic administration of PEA reduces IOP and improves visual field indices in individuals affected by NTG"
  • Metformin Linked to Reduced Risk for Glaucoma - Medscape, 5/13/14 - "The risk for open-angle glaucoma was 25% lower in patients with documented cumulative metformin use of more than 1110 g over 2 years (average dose, 2 g/day) than in those with no metformin use ... The association was dose-dependent, with a 0.01% reduced hazard for open-angle glaucoma with every 1 g increase in metformin ... The greatest risk reduction was associated with the highest baseline risk and the highest glycated hemoglobin (HbA1c) levels ... The findings support the concept that metformin and some other drugs are geroprotective because they produce effects that mimic caloric restriction"
  • Omega 3:6 ratio intake and incidence of glaucoma: The SUN cohort - Clin Nutr. 2013 Nov 12 - "followed-up 17,128 participants initially free of glaucoma for a median time of 8.2 years. Validated data of diet were collected at baseline with a 136-item semi-quantitative food-frequency questionnaire and information of new diagnosis of glaucoma in biennial follow-up questionnaires ... median follow-up time of 8.2 years ... Participants in the highest quintile of omega 3:6 ratio intake had a significantly higher risk of glaucoma than participants in the lowest quintile (hazard ratio (HR): 1.91 [95%CI: 1.05-3.46], p for trend 0.03). The association became stronger (HR for the comparison of the 5th versus the 1st quintile: 2.43 [95%CI: 1.17-5.03], p for trend 0.02) when we considered only those participants who were ≥40 years old" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Nutrients Promote Eye Health in Aging, Says Panel - Medscape, 4/17/12 - "They pointed out that many multivitamin supplements do not contain nutrients important for eye health, including lutein, zeaxanthin, and long-chain omega-3 fatty acids. "Taking a supplement specifically designed for eye health that contains these key nutrients, in addition to a general nutritional supplement, may therefore be a better approach to filling dietary shortfalls,""
  • Physical fitness could have a positive effect on eye health - Science Daily, 10/24/11 - "low ocular perfusion pressure (OPP), an important risk factor for glaucoma ... From 2006 to 2010, study participants were examined for eye pressure -- medically termed intraocular pressure (IOP ) -- and systolic and diastolic blood pressure measurements. The results showed that moderate physical exercise performed approximately 15 years previously is associated with a 25% reduced risk of low OPP"
  • Ocular hypotensive effect of oral palmitoyl-ethanolamide: a clinical trial - Invest Ophthalmol Vis Sci 2011 Aug 3 - "intraocular pressure (IOP) in primary open angle glaucoma (POAG) and ocular hypertension (OH) ... 42 patients with POAG or OH who were treated with timolol 0.5% and whose IOP was between 19 and 24 mm Hg received oral PEA (300-mg tablets twice a day) or placebo (PEA vehicle tablets twice a day) for 2 months (period 1), and, after a 2-month washout, received the other treatment for 1 month (period 2) ... After PEA treatment (mean baseline IOP, 21.6 ± 1.7 mm Hg), IOP was reduced by 3.2 ± 1.3 mm Hg at 1 month and by 3.5 ± 1.2 mm Hg (15.9% ± 5.1%) at 2 months (ANOVA, P < 0.001; both Tukey-Kramer, P < 0.01 vs. baseline); after placebo (mean baseline IOP, 21.5 ± 1.5 mm Hg), IOP was reduced by 0.4 ± 1.2 mm Hg at 1 month and by 0.3 ± 1.3 mm Hg at 2 months (t-test at both time points, P < 0.001 vs. PEA). No statistically significant vital signs, visual field, visual acuity changes, or adverse events were detected in either group"
  • Scientists discover new role for vitamin C in the eye and the brain - Science Daily, 7/15/11 - "cells in the retina need to be 'bathed' in relatively high doses of vitamin C, inside and out, to function properly ... Because the retina is part of the central nervous system, this suggests there's likely an important role for vitamin C throughout our brains, to a degree we had not realized before ... The findings could have implications for other diseases, like glaucoma and epilepsy. Both conditions are caused by the dysfunction of nerve cells in the retina and brain that become over excited in part because GABA receptors may not be functioning properly" - See vitamin C products at Amazon.com.
  • Bilberry-pine bark mix shows eye health benefits - Nutra USA, 5/24/10 - "One group received daily Mirtogenol supplements (40 mg Pycnogenol, 80 mg Mirtoselect), one group received Latanoprost eye drops, and the third group received a combination of both ... After 24 weeks of intervention, the researchers noted a reduction of blood pressure in the eye from an average of 38.1 to 29.0 mmHg in the Mirtogenol group, from 37.7 to 27.2 mmHg in the Latanoprost group, and from 38.0 to 23.0 mmHg in the combined group. Normal eye pressure is reported to range from 10 to 21 mmHg"
  • Green Tea Good for the Eyes? - WebMD, 2/18/10 - "the compounds responsible for many of the health benefits of green tea are capable of penetrating the tissues of the eyes and have antioxidant activity there ... catechins are among a number of antioxidants, including vitamin C, vitamin E, lutein, and zeaxanthin, thought to help protect the delicate tissues of the eye from glaucoma and other eye diseases. But until now it wasn't known if the catechins in green tea were capable of being absorbed into the tissues of the eye ... The results showed that different parts of the eye absorbed varying amounts of catechins. The area with the highest concentration of catechins was the retina, which is the light-sensing tissue that lines the back of the eye" - [Science Daily] - See green tea extract at Amazon.com.
  • Nutritional Strategies for Preventing Age-Related Vision Loss - Life Extension Magazine, 5/06
  • Bilberry and pine bark combo wards off glaucoma: study - Nutra USA, 7/24/08 - "intra-ocular hypertension (IOP) ... The bilberry and pine bark product was Mirtogenol, a combination of Indena's Mirtoselect standardised bilberry extract and Horphag's Pycnogenol pine bark extract ... IOP was also seen to be lowered in 19 of the 20 intervention patients, from an average of 25.2mmHg to 22.0mmHG. Only one of the control patients saw a drop in IOP" - [Abstract] - See bilberry at Amazon.com and Pycnogenol at Amazon.com.
  • Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects - Mol Vis. 2008 Jul 10;14:1288-92 - "intraocular pressure (IOP) ... After two months of supplementation with Mirtogenol, the mean IOP decreased from a baseline of 25.2 mmHg to 22.2 mmHg. After three months of treatment with Mirtogenol, the IOP was significantly lowered compared to that of untreated controls (p<0.05) to 22.0 mmHg" - [Nutra USA] - See bilberry at Amazon.com and Pycnogenol at Amazon.com.
  • Tight Necktie May Boost Glaucoma Risk - WebMD, 7/28/03 - "a too-tight necktie may increase the risk of glaucoma by boosting blood pressure inside the eyes to dangerous levels"
  • Ginkgo Improves Some Glaucoma - New Hope Natural Media, 5/16/03 - "27 people with normal tension glaucoma and visual field losses were randomly assigned to one of two groups. One group received 40 mg of Ginkgo biloba extract three times per day for four weeks, followed by eight weeks with no treatment and finally four weeks of placebo. The other group received placebo for four weeks, followed by the same eight weeks with no treatment and ending with four weeks of Ginkgo biloba. Both groups experienced significant improvement (approximately 24%) in indices used to evaluate visual fields after treatment with Ginkgo biloba. There were no improvements for either group during placebo phases ... Ginkgo biloba extract has several properties that might have contributed to the beneficial effects observed in this trial. Its antioxidant activity might have protected the optic nerve from oxidative damage, and its ability to increase blood flow and oxygen utilization might have protected the optic nerve from damage due to lack of oxygen" - See ginkgo biloba at Amazon.com.

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