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Liver Cancer

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• Meta-analysis: Chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin - Aliment Pharmacol Ther 2023 Mar - "Although statin and aspirin use were associated with reduced HCC risk, only statin use was significant in subgroup analyses accounting for concurrent medications. Metformin use was not associated with reduced HCC risk"
• Study of Sirolimus in Patients With Advanced Pancreatic Cancer - clinicaltrials.gov, 9/7/18 - "In preclinical studies, investigators found that rapamycin can effectively inhibit the angiogenesis of liver Cancer led by tumor-associated macrophages (TAM), thereby inhibiting the progression of liver Cancer.In vitro experiments on pancreatic cancer showed that rapamycin can directly inhibit the proliferation of pancreatic cancer cells.After the treatment with rapamycin in the homologous xenograft tumor model of mice, it was found that the tumor growth of mice was significantly inhibited. Further analysis suggested that rapamycin not only directly inhibits tumor proliferation, but also reverses the immune suppressive microenvironment of pancreatic cancer and promotes the T-cell-mediated anti-tumor immune response.Preclinical findings suggest that rapamycin may benefit survival in pancreatic cancer patients, which makes us very interested in the efficacy of rapamycin in patients with advanced pancreatic cancer" - See Siromus (rapamycin) at ReliableRXPharmacy.
• Combinatorial treatment with Silybum marianum essential oil enhances the therapeutic efficacy of a 5-fluorouracil base therapy for hepatocellular carcinoma - Phytother Res 2023 Feb 14 - "Silybum marianum seeds contain a family of flavonolignans which can regulate cancer cell proliferation and apoptosis ... Results revealed that the combination of S. marianum and 5-FU prolonged survival in a mouse model of HCC compared to either treatment alone" - See Silybum marianum oil at Amazon.com.
• Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis - Evid Based Complement Alternat Med 2022 Nov 23 - "Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, with a high incidence and mortality rate. Glucose metabolism reprogramming is a major characteristic of tumor cells. Increasing evidence indicates that aerobic glycolysis is associated with tumor growth and insensitivity to chemotherapy. Cordycepin inhibits the growth of HCC cells, but the mechanism is yet to be elucidated ... Taken together, these findings revealed that cordycepin reduces the tumor energy supply and decreases lactic acid production, thereby inhibiting the growth of HCC cells by regulating the metabolic pathway of aerobic glycolysis. These findings might provide novel insights into the mechanisms underlying cordycepin-mediated inhibition of tumor growth as well as a new treatment for HCC" - See Cordyceps at Amazon.com.
• Se-Methylselenocysteine Alleviates Liver Injury in Diethylnitrosamine (DEN)-Induced Hepatocellular Carcinoma Rat Model by Reducing Liver Enzymes, Inhibiting Angiogenesis, and Suppressing Nitric Oxide (NO)/Nitric Oxide Synthase (NOS) Signaling Pathway - Med Sci Monit 2021 Aug 4 - "Hepatocellular carcinoma is the third leading cause of cancer-associated mortality. This study aimed to investigate the effects of se-methylselenocysteine (MSC) on oncogenesis of diethylnitrosamine (DEN)-induced hepatocellular carcinoma ... MSC administration alleviated liver injury in a DEN-induced hepatocellular carcinoma rat model through reducing liver enzymes, inhibiting angiogenesis, and suppressing the NO/NOS signaling pathway" - See se-methyl l-selenocysteine at Amazon.com and iHerb.
• ATXN7L3B promotes hepatocellular carcinoma stemness and is downregulated by metformin - Biochem Biophys Res Commun 2021 Aug 6 - "Hepatocellular carcinoma (HCC) is the major cause of liver cancer-associated morality. Metformin, used for treating type 2 diabetes, has antitumor activity and reduces the risk of some diabetes-related tumors, such as liver and breast cancer ... metformin reduced ATXN7L3B level in HCC cells. ATXN7L3B expression was significantly negatively correlated with survival in liver cancer patients. We also demonstrated that ATXN7L3B promoted HCC stemness. Metformin treatment decreased ATXN7L3B-induced tumor-initiating ability in a HCC mouse model, implying that metformin may inhibit cancer stemness by downregulating ATXN7L3B. Our study supports the antitumor activity of metformin and its potential as an anticancer drug for HCC treatment" - See metformin at ReliableRX.
• Magnesium intake is associated with a reduced risk of incident liver cancer, based on an analysis of the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study prospective cohort - Am J Clin Nutr 2020 Dec 16 - "Higher magnesium intake was independently associated with a lower risk of liver cancer (P-trend = 0.005), with intakes in the highest compared with lowest quartile associated with 35% lower risk (HR: 0.65; 95% CI: 0.48, 0.87). The dose-related inverse association was more pronounced in moderate and heavy alcohol users (HR: 0.54; 95% CI: 0.35, 0.82; P-trend = 0.006), and this interaction was statistically significant ... Based on a prospective cohort analysis, we demonstrated that magnesium intake is associated with a lower risk of primary liver cancer, which was more pronounced among moderate and heavy alcohol users" - See Jarrow Formulas, MagMind at Amazon.com.
• Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR-21/TIMP3 Axis - Evid Based Complement Alternat Med 2020 Jul 17 - "Curcumin exhibits anticancer effects against various types of cancer including hepatocellular carcinoma (HCC). miR-21 has been reported to be involved in the malignant biological properties of HCC ... Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-β1/smad3 signaling pathway" - See curcumin at Amazon.com and iHerb.
• Chronic inflammatory liver diseases and coffee intake - Curr Opin Clin Nutr Metab Care. 2019 Jun 18 - "A regular coffee consumption may have preventive healthy effects, especially if consumed without added sugars. Certainly, coffee consumption should not be prohibited in individuals with chronic inflammatory liver diseases, including hepatocellular carcinoma"
• Liver, colon cancer cells thwarted by compounds derived from hops - Science Daily, 4/2/19 - "xanthohumol, known as XN ... XN had been shown to inhibit proliferation of a variety of cancer cell lines, and in this study, we demonstrated XN's ability to halt cell growth and kill two liver cancer cell lines and two colon cancer cell lines" - See xanthohumol at Amazon.com.
• Association of 25-hydroxyvitamin D with liver cancer incidence and chronic liver disease mortality in Finnish male smokers of the ATBC study - Cancer Epidemiol Biomarkers Prev. 2018 May 2 - "Our results suggest a possible preventive role for vitamin D against liver cancer and CLD, although the importance of the liver for vitamin D metabolism and the lack of information about underlying liver disease makes reverse causality a concern" - See vitamin D at Amazon.com.
• Selenium status influence cancer risk - Science Daily, 8/31/16 - "the third of the population with lowest selenium status have a five- to ten-fold increased risk of developing hepatocellular carcinoma -- also known as liver cancer"
• Effect of Pomegranate Hull Extract on Liver Neoplastic Changes in Rats: More than an Antioxidant - Nutr Cancer. 2016 Jul 6 - "The current work was designed to elucidate the molecular mechanisms underlying the antitumorigenic effect of pomegranate hull extract (PHE) in livers of rats exposed to the hepatocarcinogen diethyl nitrosamine (DENA) with emphasis on oxidative stress, proliferation, and apoptosis. Male albino rats were divided into three groups: normal control, DENA group, and PHE group. PHE was given to rats orally 3 times weekly for 10 wk, 4 wk before and 6 wk after DENA (200 mg/kg, single i.p. dose). The results indicated a prophylactic effect of PHE against neoplastic changes in the liver, which was evidenced by the decrease of tumor size, liver index, and the anti-apoptotic protein Bcl-2; and the increase of glutathione. PHE group also showed decreased expression of liver cyclin D1 and β-catenin genes compared with DENA group. It is proved that PHE has antitumorigenic effect and could be a candidate for anticancer drugs" - See pomegranate extract at Amazon.com.
• Inflammatory potential of diet and risk for hepatocellular cancer in a case-control study from Italy - Br J Nutr. 2015 Nov 11:1-8 - "dietary inflammatory index (DII). The DII was computed on the basis of dietary intake assessed 2 years before the date of interview ... Participants in the highest tertile of DII scores (i.e. with a more pro-inflammatory diet) had a higher risk for HCC (ORtertile 3 v, 1 2.43"
• Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced Hepatocellular Carcinoma - Nutr Cancer. 2015 Oct 16:1-8 - "The study provides evidence that prophylactic dietary supplementation with LycT may counteract HCC progression and/or protect against disease onset" - See lycopene at Amazon.com.
• Coffee consumption and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma by sex: The Liver Cancer Pooling Project - Cancer Epidemiol Biomarkers Prev. 2015 Jun 30 - "Higher coffee consumption was associated with lower risk of HCC (HR>3 cups/day vs. non-drinker, 0.73; 95% CI, 0.53-0.99; ptrend cups/day=<0.0001). More notable reduced risk was seen among women than men (pinteraction=0.07). Women who consumed more than three cups of coffee per day were at a 54% lower risk of HCC (HR, 0.46; 95% CI, 0.26-0.81), whereas men had more modest reduced risk of HCC (HR, 0.93; 95% CI, 0.63-1.37). The associations were stronger for caffeinated coffee (HR>3 cups/day vs. non-drinker, 0.71, 95% CI, 0.50-1.01) than decaffeinated coffee (HR, 0.92; 95% CI, 0.55-1.54)"
• Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy - Cancer Lett. 2015 May 12 - "Here, we utilised patient-derived colorectal liver metastases (CRLM) to assess whether curcumin may provide added benefit over 5-fluorouracil (5-FU) and oxaliplatin (FOLFOX) in cancer stem cell (CSC) models ... Curcumin alone and in combination, significantly reduced spheroid number in CRLM CSC models, and decreased the number of cells with high aldehyde dehydrogenase activity (ALDH(high)/CD133(-)). Addition of curcumin to oxaliplatin/5-FU enhanced anti-proliferative and pro-apoptotic effects in a proportion of patient-derived explants, whilst reducing expression of stem cell-associated markers ALDH and CD133" - See curcumin products at Amazon.com.
• Statin use and risk of primary liver cancer in the clinical practice research datalink - J Natl Cancer Inst. 2015 Feb 26;107(4) - "Statin use was associated with a statistically significantly reduced risk of liver cancer (ORadj = 0.55, 95% CI = 0.45 to 0.69), especially among current users (ORadj = 0.53, 95% CI = 0.42 to 0.66). The reduced risk was statistically significant in the presence (ORadj = 0.32, 95% CI = 0.17 to 0.57) and absence of liver disease (ORadj = 0.65, 95% CI = 0.52 to 0.81) and in the presence (ORadj = 0.30, 95% CI = 0.21 to 0.42) and absence of diabetes (ORadj = 0.66, 95% CI = 0.51 to 0.85)"
• Fish consumption and n-3 polyunsaturated fatty acids, and risk of hepatocellular carcinoma: systematic review and meta-analysis - Cancer Causes Control. 2014 Dec 23 - "n-3 PUFA was associated with 51 % reduction in HCC risk (highest vs. lowest category SRRs = 0.49, 95 % CI 0.19-0.79). However, no significant inverse association was found in ALA" - See fish oil supplements at Amazon.com.
• Derivative of vitamin B3 prevents liver cancer in mice - Science Daily, 11/20/14 - "nicotinamide adenine dinucleotide (NAD+) ... When the scientists supplemented the diet in genetically modified mice with nicotinamide riboside, a derivative of vitamin B3 that increases intracellular levels of NAD+, they did not observe tumour development. Surprisingly, when they gave this diet to mice that had already developed the disease, the size of the tumours was reduced and they eventually disappeared" - See nicotinamide adenine dinucleotide at Amazon.com and nicotinamide riboside at Amazon.com.
• Study Links Coffee to Lower Liver Cancer Risk - WebMD, 4/9/14 - "the study started in the 1990s, researchers asked nearly 180,000 adults of different racial and ethnic backgrounds about their coffee drinking and other lifestyle habits ... tracked for as long as 18 years ... People who said they drank one to three cups of coffee a day had a 29 percent reduced risk of liver cancer compared to those who drank six cups or less each week. And more was apparently better: People who regularly had more than four cups of coffee a day had a 42 percent reduced risk ... coffee has close to 100 active compounds including antioxidants, polyphenols and caffeine. It's also known to affect liver enzymes"
• Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways - Cancer Lett. 2014 Jan 30 - "Hydroxytyrosol (HT), a natural polyphenolic compound in olive oil, has been proved to possess significant antitumor activity in several cancer cells. However, effects of HT on human hepatocellular carcinoma (HCC) cells are still largely unknown ... HT could suppress the growth of HCC in vitro and in vivo, the mechanism is at least partially due to the suppressive effect of HT on the activation of AKT and NF-κB pathways. Thus it may be a promising candidate agent for the treatment of HCC" - See olive leaf extract at Amazon.com.
• Coffee Consumption and Chronic Liver Disease - Medscape, 1/6/14 - "Sixteen studies were identified. Overall, compared with no coffee consumption, the risk for HCC was reduced by 28% with low-level consumption, and by 36% with high-level consumption (3 or more cups/day). It is likely that this favorable effect is the result of reduced cirrhosis evident in coffee drinkers, as well as improvement in the metabolic syndrome, because diabetes is another known risk factor for HCC ... There are differences in coffee bean composition as well as extractions used in preparation, but these findings seem to be specifically related to brewed, roasted, regular (not decaffeinated) coffee. Of interest, the beneficial effects have not been evident in nonfiltered, boiled (Turkish), or French press preparations ... Reportedly, there are more than 1500 chemical components of coffee, which are subject to agricultural and preparation-related influences. Although caffeine is the major active ingredient, many other components have significant antioxidant activity"
• Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis - Mol Nutr Food Res. 2013 Oct 1 - "Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis (initiated-promoted group). Initiated-promoted animals also received quercetin 10 and 20 mg/kg body weight (IPQ10 and IPQ20 groups, respectively). Antioxidant defenses were modified by quercetin administration at both doses. However, only IPQ20 group showed a reduction in number and volume of preneoplastic lesions. This group showed increased apoptosis and a reduction in the proliferative index" - See quercetin at Amazon.com.
• The Effect of Coffee Consumption on the Development of HCC - Medscape, 8/12/13 - "a high lifetime coffee consumption (≥20 000 cups) was an independent protective factor against HCC, in each analyses using healthy and risky control groups respectively (HCE group, OR 0.56, 95% CI 0.33–0.95; CLD group, OR 0.55, 95% CI 0.36–0.85). However, the high coffee consumption did not affect the HCC risk in patients with HBV (OR 0.64, 95% CI 0.36–1.14) after adjustment for HBeAg status, serum HBV DNA level and antiviral therapy"
• Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat - Clin Nutr. 2013 May 17 - "Large-scale epidemiological studies have shown that drinking more than two cups of coffee per day reduces the risks of hepatitis and liver cancer ... Coffee administration for 25 weeks delayed the occurrence of hepatitis by two weeks, significantly improved survival, reduced the expression of inflammatory cytokines, and reduced the incidence of small pre-neoplastic liver foci in LEC rats ... This study showed the efficacy of coffee in the prevention of hepatitis and liver carcinogenesis in the LEC model"
• Coffee Consumption and Risk of Liver Cancer - Medscape, 4/22/13 - "searched Medline, EMBASE, ISI Web of Science and the Cochrane library for studies published up to May 2012 ... The summary odds ratio (OR) for high vs no/almost never drinkers was 0.50 (95% confidence interval (CI): 0.42–0.59), with no significant heterogeneity across studies (Q = 16.71; P = 0.337; I2 = 10.2%). The ORs were 0.50 (95% CI: 0.40–0.63) for case–control studies and 0.48 (95% CI: 0.38–0.62) for cohort studies. The OR was 0.38 (95% CI: 0.25–0.56) in males and 0.60 (95% CI: 0.33–1.10) in females. The OR was 0.45 (95% CI: 0.36–0.56) in Asian studies and 0.57 (95% CI: 0.44–0.75) in European studies. The OR was 0.39 (95% CI: 0.28–0.54) with no adjustment for a history of liver disease and 0.54 (95% CI: 0.46–0.66) after adjustment for a history of liver disease"
• NSAID use linked to reduced hepatocellular carcinoma risk and mortality due to chronic liver disease - Science Daily, 11/28/12 - "Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, occurs mainly among patients with CLD ... performed an observational study of 300,504 men and women aged 50 to 71 years enrolled in the National Institutes of Health-AARP Diet and Health Study who reported their aspirin and nonaspirin NSAID use and were followed-up for 10-12 years ... Study participants who used aspirin had a 41% reduced risk of HCC and a 45% reduced risk of death from CLD, whereas those who used non-aspirin NSAIDs experienced a 26% reduced risk of CLD mortality but no reduced risk of HCC" - [Abstract]
• Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis - Scand J Gastroenterol. 2012 Nov 9 - "Medline and Embase databases were searched to identify the relevant studies between January 1966 and December 2011 ... the overall prevalence of HCC was 3.40% (562/16,549) in DM patients. The overall analysis showed a significantly reduced risk of HCC in metformin users versus nonusers in diabetic patients (relative risk (RR) 0.24, 95% confidence interval (CI) 0.13-0.46, p < 0.001)" - See metformin at The Antiaging Store.
• Vitamin E may lower liver cancer risk - Science Daily, 7/17/12 - "China who were enrolled in the Shanghai Women's Health Study (SWHS) from 1997-2000 or the Shanghai Men's Health Study (SMHS) from 2002-2006, two population-based cohort studies jointly conducted by the Shanghai Cancer Institute and Vanderbilt University. Using validated food-frequency questionnaires, the researchers conducted in-person interviews to gather data on study participants' dietary habits. They compared liver cancer risk among participants who had high intake of vitamin E with those with low intake ... Vitamin E intake from diet and vitamin E supplement use were both associated with a lower risk of liver cancer. This association was consistent among participants with and without self-reported liver disease or a family history of liver cancer" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
• Metformin for Liver Cancer Prevention in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis - J Clin Endocrinol Metab. 2012 Apr 20 - "In meta-analyses, metformin was associated with an estimated 62% reduction in the risk of liver cancer among patients with type 2 diabetes ... When restricting the analysis to the four studies related to hepatocellular carcinoma, metformin was again associated with a significantly lower cancer risk (odds ratio 0.30, 95% confidence interval 0.17, 0.52; P < 0.001), and there was evidence of significant heterogeneity between these four studies" - See metformin at The Antiaging Store.
• Spectroscopic Characterization of Lycopene Extract from Lycopersicum esculentum (Tomato) and Its Evaluation as a Chemopreventive Agent Against Experimental Hepatocarcinogenesis in Mice - Phytother Res. 2012 May 25 - "The present study was designed to characterize the lycopene extract (LycT) prepared from tomatoes (Lycopersicum esculentum) and then to evaluate its chemopreventive efficacy in N-diethylnitrosamine (NDEA)-induced experimental hepatocarcinogenesis in female Balb/c mice ... In the animal study, reduction in tumour incidence (42.05%), tumour burden (1.39) and tumour multiplicity (3.42) was observed upon LycT pretreatment to NDEA-treated animals. Histopathological analysis unravelled that the increased survival rate in LycT + NDEA-treated animals was due to the delay in the formation of aggressive tumour nodules. These observations indicate that lycopene seems to be an able candidate for chemoprevention in hepatocarcinogenesis resulting from NDEA insults" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
• Metformin may protect against liver cancer - Science Daily, 3/31/12 - "chemically induced liver tumors in mice. The mice taking metformin displayed minimal tumor activity, while the control mice displayed significant tumor growth ... Girnun's team also showed that metformin prevented liver cancer in part by inhibiting lipid synthesis in the liver, a process known to promote cancer" - See metformin at The Antiaging Store.
• Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study - Cancer Causes Control. 2011 Jan 22 - "High levels of coffee or caffeine consumption were associated with reduced risk of HCC (p for trend < 0.05). Compared with non-drinkers of coffee, individuals who consumed three or more cups of coffee per day experienced a statistically significant 44% reduction in risk of HCC (hazard ratio 0.56, 95% confidence interval, 0.31-1.00, p = .049) after adjustment for potential confounders and tea consumption"
• γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an anti-proliferative, pro-apoptotic and chemosensitizing agent - Br J Pharmacol. 2010 Dec 30 - "Overall, these results suggest that γ-tocotrienol is a novel blocker of the STAT3 activation pathway, with a potential role in future therapies for HCC and other cancers" - Note: The γ symbol stands for gamma.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
• Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial - Anticancer Res. 2010 Dec;30(12):5145-5151 - "arabinoxylan rice bran (MGN-3) in conjunction with an interventional therapy (IT) for the treatment of hepatocellular carcinoma patients ... Patients in the IT+MGN-3 group showed: (i) lower recurrence of the disease, 31.6% (12/38), as compared to 46.7% (14/30) for the control; (ii) higher survival after the second year, 35%, as compared to 6.7% for the control; (iii) significantly lower alpha-fetoprotein level, a 38% decrease (p=0.0001), as compared to baseline value, while the control showed no significant change; and (iv) a significant decrease in tumor volume, in contrast to the control, which showed no significant change. When the results were analyzed according to each IT modality, MGN-3+IT sub-groups displayed a greater response to treatment, in every aspect examined, than the IT sub-groups alone. However, the patients in the MGN-3+TOCE+PEIT sub-group demonstrated greater reduction in AFP levels and longer survival time than the MGN-3+TOCE sub-group" - See arabinoxylan at iHerb.
• Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis - Int J Cancer. 2010 Sep 7 - "Cholangiocarcinoma (CCA) is a highly metastatic tumor linked to liver fluke infection and consumption of nitrosamine-contaminated foods, and is a major health problem especially in South-Eastern Asia ... Our results suggest that curcumin exhibits an anticarcinogenic potential via suppression of various events involved in multiple steps of carcinogenesis, which is accounted for by its ability to suppress proinflammatory pathways" - See curcumin products at Amazon.com.
• Coffee and the liver: a potential treatment for liver disease? - Eur J Gastroenterol Hepatol. 2010 Aug 26 - "Several studies consistently show that coffee drinkers have a reduced risk of abnormal liver function tests, cirrhosis and hepatocellular carcinoma. There is a clear dose response to this benefit"
• Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice - Biochem Pharmacol. 2009 Dec 1;78(11):1391-400 - "CoQ10 supplementation decreased the global hepatic mRNA expression of inflammatory and metabolic stresses markers without changing obesity and tissue lipid peroxides compared to HFF mice" - See ubiquinol products at Amazon.com.
• Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study - Cancer Causes Control. 2009 Sep 19 - "Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for >/=5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90)" - See green tea extract at Amazon.com.
• Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary Liver Cancer In Rats - Science Daily, 7/30/09 - "A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats" - [Abstract] - See SAM-e at Amazon.com.
• S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model - Hepatology. 2009 Apr 6 - "SAMe is effective in preventing HCC establishment but ineffective in treating established HCC because of induction of hepatic methyltransferases, which prevents SAMe level to reach high enough to kill liver cancer cells. SAMe's chemopreventive effect may be related to its proapoptotic action and its ability to inhibit angiogenes" - See SAM-e at Amazon.com.
• Red Wine Protects against Ethanol-Induced Oxidative Stress in Rat Liver - J Agric Food Chem. 2009 Jun 23 - "Red wine (RW) is rich in polyphenolic antioxidants, often reported as hepatoprotective agents ... Six-month-old Wistar rats were treated with RW or EtOH; controls were pair-fed. EtOH increased 8-hydroxy-2'-deoxyguanosine and decreased reduced and oxidized glutathione. These animals also displayed stimulated superoxide dismutase, catalase, and glutathione reductase activities. RW treatment decreased malondialdehyde and reduced glutathione levels. Glutathione-S-transferase and selenium-dependent glutathione peroxidase activities were stimulated and glutathione reductase activity was inhibited by RW intake. No modifications were detected in nuclear factor-kappa B or alkaline phosphatase activities. EtOH consumption induced fibrosis in portal spaces and hepatocyte lipid accumulation that were absent with RW treatment. This paper highlights the importance of RW nonalcoholic components and the relevance of biological matrix in the study of EtOH oxidative effects"
• Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats - Int J Cancer. 2009 Jun 23 - "Epidemiological and experimental studies provide supportive evidence that lycopene (LY), a major carotenoid from tomatoes and tomato products, may act as a chemopreventive agent against certain types of cancers. We recently showed that high-fat diet (HFD)-induced nonalcoholic steatohepatitis (NASH) promoted diethylnitrosamine (DEN)-initiated hepatocarcinogenesis in a rat model ... tomato extract (TE) ... These data indicate that LY and TE can inhibit NASH-promoted hepatocarcinogenesis mainly as a result of reduced oxidative stress, which could be fulfilled through different mechanisms" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
• Vitamin K2 Suppresses Proliferation and Motility of Hepatocellular Carcinoma Cells by Activating Steroid and Xenobiotic Receptor - Endocr J. 2009 Jun 24 - "These results suggest that the activation of SXR could contribute to tumor suppressive effects of vitamin K2 on HCC cells" - See vitamin K at Amazon.com.
• Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by Hepatitis Virus Infection Status - Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1746-1753 - "Compared with almost never drinkers, increased coffee consumption was associated with a reduced risk of liver cancer in all subjects (hazard ratio for <1, 1-2, and >/=3 cups/d; P(trend) = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects"
• Higher Coffee Consumption Associated With Lower Liver Cancer Risk - Science Daily, 6/26/08 - "0-1 cup, 2-3 cups, 4-5 cups, 6-7 cups, and 8 or more cups per day ... The researchers noted a significant inverse association between coffee drinking and the risk of primary liver cancer. They found that the multivariable hazards ratio of liver cancer dropped for each group that drank more coffee. It fell from 1.00, to .66, to .44, to .38 to .32 respectively"
• Coffee May Curb Liver Cancer - WebMD, 8/2/07
• An Attempt to Evaluate the Effect of Vitamin K(3) Using as an Enhancer of Anticancer Agents - Biol Pharm Bull. 2008;31(6):1270-1273 - "These findings suggest that VK(3) induces G(2)/M arrest by inhibition of cyclin B/cdk1 complex formation, and is thus useful as an enhancer of G(2) phase-dependent drugs in hepatic cancer chemotherapy" - See vitamin K at Amazon.com.
• Flavonoid intake and liver cancer: a case-control study in Greece - Cancer Causes Control. 2008 Mar 19 - "hepatocellular carcinoma (HCC) ... Flavone intake, mostly derived from spinach and peppers, was inversely associated with both virus positive (P-trend, 0.049) and virus negative (P-trend, 0.084) HCC"
• Vitamin K(2) suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43 - Cancer Lett. 2008 Jan 29 - "The anti-cancer potential of vitamin K(2) (VK(2)) in hepatoma has gained considerable attention" - See vitamin K2 products at iHerb.
• Scientific Evidence Of The Significant Anti-cancer Effect Of Milk Thistle - Science Daily, 11/14/07 - "Their research results indicate that silibinin can be used to prevent the development of liver cancer, one of the most common cancers worldwide" - See silymarin at Amazon.com.
• Coffee Drinking Related To Reduced Risk Of Liver Cancer - Science Daily, 8/1/07 - "hepatocellular carcinoma (HCC) ... The results showed a 41 percent reduction of HCC risk among coffee drinkers compared to those who never drank coffee"
• Folate may reduce liver damage study - Nutra USA, 7/6/07 - "higher red blood cell folate levels were associated with a 67 per cent reduced risk of liver cancer" - [Abstract] - See folic acid at Amazon.com.
• Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort - Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1279-82 - "When comparing persons in the lowest quartile RBC folate to persons in all other quartiles, the analysis found that higher RBC folate levels were associated with reduced risk of hepatocarcinogenesis (odds ratio, 0.33" - See folic acid at Amazon.com.
• Garlic compounds may stop liver cancer growth - Nutra USA, 5/4/06 - "A one per cent solution of each garlic extracts appeared to inhibit the growth of the tumour completely"
• Omega-3s could stop liver cancer cells growth - Nutra USA, 4/3/06 - "Both omega-3 fatty acids had a dose-dependent inhibitory effect"
• More evidence coffee may cut risk of liver cancer - Nutra USA, 8/4/05 - "those who drink coffee occasionally reduced their risk by almost 30 per cent, while those drinking one or more cups a day had a risk of just 0.58 compared with the non-drinkers"
• Studies Examine Coffee Drinking And Risk Of Liver And Colorectal Cancers - Science Daily, 2/23/05 - "People who drank coffee on a daily or almost daily basis had about half the risk of HCC [hepatocellular carcinoma] compared with those who never drank coffee"
• Can Coffee Protect Against Common Cancers? - WebMD, 2/15/05 - "Recent studies have shown that regular coffee consumption may lower the risk of developing diseases such as diabetes and Parkinson's ... people who drank coffee every day or almost daily had about half the liver cancer risk as those who never drank coffee. The more coffee people drank the lower their risk"
• Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver - JAMA. 2004 Jul 21;292(3):358-61 - "Hepatocellular carcinoma was detected in 2 of the 21 women given vitamin K2 and 9 of the 19 women in the control group ... the risk ratio for the development of hepatocellular carcinoma in patients given vitamin K2 was 0.13" - See Vitamin K2 products at iHerb.
• Research Finds Tumor Preventive Qualities, Damage Reversal, In Green Tea - Intelihealth, 10/29/03 - "At the same time, we see the value of green tea polyphenols in reducing excretion of 8-OHdG. All of this is good news for the prevention and early detection of liver cancer" - See iHerb green tea products.
• Adding Folates Alters Methotrexate Treatment In Rheumatoid Arthritics - Doctor's Guide, 4/21/03 - "The researchers found the addition of folates to MTX treatment was strongly linked with lack of hepatotoxicity" - See iHerb folic acid products.
• Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 - "Companies that manufacture selenium supplements will now be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers" - See iHerb selenium products.
• Wow, You Coulda Had Some Lycopene! - Cancer Decisions Newsletter , 1/7/03 - "Lycopene may also help prevent liver cancer, according to findings from a study presented at the American Association for Cancer Research meeting in October 2002. Hoyoku Nishino, MD, of the Kyoto Prefectural University of Medicine, Japan, presented the results of this five-year clinical study examining the protective role of lycopene and other nutrients in people at high risk of liver cancer. There was a 50 percent decrease in hepatocellular carcinoma (HCC or liver cancer) in participants who daily consumed 10 milligrams of tomato lycopene plus other tomato phytonutrients, 10 milligrams of carotenes (30 percent alpha, 60 percent beta-carotene), and 50 milligrams of alpha-tocopherols and another form of vitamin E, tocotrienols" - See iHerb lycopene products.  My favorite is Lyco-Sorb, which has the brand name Lyc-O-Mato.
• Cancer Researchers Keen on Tomatoes - WebMD, 11/11/02 - "For example, a five-year Japanese study shows daily use of a supplement that contained a combination of natural tomato extract, beta-carotene, and vitamin E might be an effective way to reduce the risk of liver cancer in those at risk. Researchers found that patients who received the supplement had a 50% suppression of liver cancer" - See iHerb lycopene products.  My favorite is Lyco-Sorb, which has the brand name Lyc-O-Mato.
• Vitamin K Therapy Slows Spread of Liver Cancer - Doctor's Guide, 5/29/02 - "Results show that 59 percent of patients treated with vitamin K-II were alive at two years compared to 29 percent of those who were not given vitamin K-II (p=0.14). Invasion of the cancer into the portal vein occurred in 2 percent of the vitamin K-II treated group at one year and in 13 percent at two years, compared to 21 and 55 percent of controls, respectively" - See Vitamin K2 products at iHerb.  Vitamin K3 (menadione sodium bisulfite) is put in animal foods and animal vitamins. Places that sell it in bulk are http://www.dyets.com/ordering.htm ($156/kilogram).  A company at 360-387-0129 called me and said they sell it also.
• Schisandra Berries More Than a Liver Aid - Nutrition Science News, 1/01
• Chemicals in apples slow cancer growth in lab tests, scientists report - CNN, 8/30/00
• Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 - "The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases"

Other News:

• PFAS 'Forever Chemicals' Are Linked With Liver Cancer - WebMD, 8/10/22 - "The strongest link was between PFOS and liver cancer. People with PFOS levels in the top 10% were 4.5 times more likely to develop liver cancer than those with the lowest levels"
• Association Between Proton Pump Inhibitors and the Risk of Hepatocellular Carcinoma - Medscape, 9/13/18 - "The adjusted odds ratio (AOR) for HCC associated with PPI use was 2.86"
• Proton Pump Inhibitor and Histamine–2 Receptor Antagonist Use and Risk of Liver Cancer in Two Population–Based Studies - Medscape, 8/2/18 - "ever use of PPIs was associated with increased liver cancer risk (adjusted OR 1.80, 95% CI 1.34, 2.41 and adjusted HR 1.99, 95% CI 1.34, 2.94 respectively)"
• Anti-Diabetic Medications and the Risk of Hepatocellular Cancer: A Systematic Review and Meta-Analysis - Am J Gastroenterol. 2013 Feb 5 - "anti-diabetic medications (ADMs) ... performed a systematic review and meta-analyses of studies evaluating the effect of metformin, thiazolidinediones (TZDs), sulfonylureas, and/or insulin on the risk of HCC ... Meta-analysis of observational studies showed a 50% reduction in HCC incidence with metformin use (n=8 studies; OR 0.50, 95% CI 0.34-0.73), 62% and 161% increase in HCC incidence with sulfonylurea (n=8 studies; OR 1.62, 95% CI 1.16-2.24) or insulin use (n=7; OR 2.61, 95% CI 1.46-4.65), respectively. TZDs did not modify the risk of HCC (n=4; OR 0.54, 95% CI 0.28-1.02). There was considerable heterogeneity across studies, which was partly explained by study setting, location, and whether the studies adjusted for the concomitant use of other ADMs"
• Combination of two drugs reverses liver tumors, study suggests - Science Daily, 5/2/12
• Novel therapeutic approach for liver cancer identified - Science Daily, 12/9/11
• Radioembolization improves chance of survival for liver cancer patients, study suggests - Science Daily, 8/22/11
• Liver Cancer Linked to Metabolic Syndrome - Medscape, 7/28/11 - "hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) ... metabolic syndrome was significantly more common in individuals who developed HCC (37.1%) and ICC (29.7%) than in a comparison group (17.1%; P < .0001). Even after multiple logistic regression analyses, metabolic syndrome remained significantly associated with an increased risk for both HCC (odds ratio, 2.13; P < .0001) and ICC (odds ratio, 1.56; P < .0001)"
• Metabolic syndrome increases risk of both major types of primary liver cancer - Science Daily, 7/21/11 - "metabolic syndrome was present in 37% of persons who subsequently developed HCC and 30% of persons who developed ICC, compared to 17% of persons who didn't develop either cancer. Analyses showed metabolic syndrome was significantly associated with increased risk of HCC (odds ratio=2.13) and ICC (odds ratio=1.56). Individual components of metabolic syndrome -- impaired fasting glucose level, dyslipoproteinemia, obesity and hypertension -- were more common among persons who developed either HCC or ICC patients than among persons who did not"
• Celecoxib May Fight Liver Cancer - Medscape, 5/24/11
• Metabolic syndrome may increase risk for liver cancer - Science Daily, 4/3/11 - "metabolic syndrome, a constellation of conditions that increases the risk of heart disease and diabetes, may also increase the risk of the two most common types of liver cancer ... The prognosis for liver cancer is only marginally better than the prognosis for pancreatic cancer, with a five-year survival of approximately 10 percent ... the persons with liver cancer were significantly more likely than cancer-free persons to have a prior history of metabolic syndrome: 37.1 percent of patients with hepatocellular carcinoma had pre-existing metabolic syndrome, as did 29.7 percent of patients with intraheptic carcinoma; only 17.1 percent of the cancer-free adults had metabolic syndrome"
• Liver cancer in cirrhotic patients effectively treated with radiofrequency ablation, study suggests - Science Daily, 12/16/10
• Adiponectin shows potential in blocking obesity-related carcinogenesis - Science Daily, 10/19/10 - "our results suggest an attractive molecular strategy employing adiponectin analogues for potential therapy of metastatic HCC ... With the prevalence of obesity in the U.S., our study could significantly improve overall survival for a vast number of obese liver cancer patients by using adiponectin to inhibit growth, invasion, and migration of HCC cells"
• Recent Advances in the Treatment of Hepatocellular Carcinoma: Abstract and Introduction - Science Daily, 4/26/10
• Radiology procedure may help increase long-term survival in patients with severe liver cancer - Science Daily, 11/20/09
• Cases Of Liver Cancer Reduced In Younger Population Vaccinated For Hepatitis B - Science Daily, 9/16/09 - "A 20-year follow-up study revealed a dramatic drop in liver cancer cases among 6- to 19-year-olds who were vaccinated for the hepatitis B virus at birth"
• Microwave Technique Successful In Treatment Of Liver Tumors, Surgeon Shows - Science Daily, 5/14/09
• Hypothyroidism In Women Associated With Liver Cancer - Science Daily, 5/8/09 - "Women with a history of hypothyroidism face a significantly higher risk of developing liver cancer ... Whether and why hypothyroidism causes HCC is not clear ... However, the association between hypothyroidism and NASH can be explained by the underlying hyperlipidemia, decreased fatty acid oxidation insulin resistance and lipid peroxidation in patients with hypothyroidism"
• Targeting The Protein AEG1 Impairs Human Liver Cancer Growth In Mice - Science Daily, 2/16/09
• Advanced Liver Cancer Patients Live Longer By Taking Anti-cancer Drug Sorafenib - Science Daily, 7/23/08
• Virus-Based Drug Attacks Liver Cancer - WebMD, 6/5/08
• Sutent, Tykerb May Curb Liver Cancer - Science Daily, 4/16/08
• Combining Liver Cancer Treatments Doubles Survival Rates, Study Suggests - Science Daily, 4/15/08
• Sunitinib May Slow Growth And Spread Of Liver Cancer - Science Daily, 4/14/08
• High-energy Ultrasound Sharpens View Of Liver Tumors - Science Daily, 1/7/08
• Radio Waves Fire Up Nanotubes Embedded In Tumors, Destroying Liver Cancer - Science Daily, 11/1/07
• ScienceDaily: Improving Liver Cancer Diagnosis - Science Daily, 10/5/07
• Sorafenib Boosts Survival in Patients With Advanced Liver Cancer - Doctor's Guide, 9/28/07
• New Test Improves Detection Of Liver Cancer - Science Daily, 8/8/07
• Why Liver Cancer Is More Prevalent In Males Than In Females - Science Daily, 7/5/07 - "By eliminating IL-6, we reduced the incidence of liver cancer in the males by close to 90%"
• Sorafenib for Advanced Liver Cancer - Medscape, 6/11/07
• Liver cancer: Kidney drug buys time - USA Today, 6/4/07
• Sorafenib is Well-Tolerated in Liver Cancer - Doctor's Guide, 11/17/06
• Elevated ALT Levels Predict Risk of Death From Liver Cancer - Medscape, 11/2/06 - "Upper limits of normal range from 30 IU/L to 60 IU/L, depending on the laboratory. "We want to reset it southward of 30 IU/L," ... ALT levels are a reflection of the general vascular condition ... If the level is above 30, then that person probably has a problem — fatty liver or some vascular disease, including occlusive coronary artery disease"
• Anti-Inflammatory Drug Prevents Liver Cancer in at-Risk Liver Patients - Doctor's Guide, 9/12/06
• FDA Grants Orphan Drug Designation to Nexavar (Sorafenib) for the Treatment of Hepatocellular Carcinoma - Doctor's Guide, 4/26/06
• Chemoembolization Effective in Destroying Liver Tumors - Doctor's Guide, 4/5/06
• Metastatic Cancer in the Liver Controlled With Treatment of Yttrium-90 Microspheres - Doctor's Guide, 4/4/06
• Yttrium-90 Controls Liver Cancer Over Long Term - Doctor's Guide, 4/4/06
• Radiofrequency Ablation Equivalent to Open Surgery in Survival of Isolated Liver Cancer - Doctor's Guide, 4/3/06
• Intraoperative Ultrasound Better Than CT or PET In Detecting Liver Metastases - Doctor's Guide, 3/27/06
• Hepatocellular Carcinoma Treatment Options Remain Limited, but New Avenues Are Being Explored: Presented at HEP DART - Doctor's Guide, 12/20/05
• Magnetic Resonance-Guided Laser Ablation Effective for Treating Liver Metastases - Doctor's Guide, 11/30/05
• Survival Unaffected by Interferon Alpha-2b after Surgical Resection for Liver Cancer - Doctor's Guide, 11/15/05
• Precision Radiation Therapy Yields Rare Success For Liver Tumors - Science Daily, 10/24/05
• Treating Liver Metastases in Colorectal Cancer: An Expert Interview With Michael Choti, MD - Medscape, 6/16/05
• Unique Dual Treatment For Liver Cancer Packs Curative Punch - Science Daily, 6/10/05
• Expandable Electrodes Safe And Effective For Radiofrequency Ablation Of Liver Tumors - Science Daily, 5/22/05
• Expandable Electrodes Safe and Effective for Radiofrequency Ablation of Liver Tumors - Doctor's Guide, 5/17/05
• Transcatheter Arterial Chemoembolization Has Minimal Toxicity in Inoperable Liver Cancer - Doctor's Guide, 4/6/05
• Radiologists Offer Non-surgical Treatment For Early-stage Liver Cancer - Science Daily, 3/5/05
• Chemotherapy Can Rescue Inoperable Colorectal Liver Metastases - Doctor's Guide, 3/4/05
• Radiofrequency Ablation Appears to Be Effective Non-Surgical Treatment for Early-Stage Liver Cancer - Doctor's Guide, 2/16/05
• Hepatic Artery Infusion Chemoembolisation Beneficial in Patients With Liver Cancer - Doctor's Guide, 2/3/05
• MRI Shows Liver Tumors Freezing In Real Time - Science Daily, 12/8/04
• Liver Metastases Destroyed by Cold Ablation - Doctor's Guide, 12/1/04
• Radiofrequency Ablation Appears to be Safe for Treating Liver Tumors Pushing on Gastrointestinal Tract - Doctor's Guide, 11/3/04
• Energy Blocker' Kills Big Tumors In Rats - Science Daily, 10/18/04
• Novel Yttrium-90 Microspheres (TheraSphere) Deliver High Radiation Levels Yet Protects Normal Tissue in Non-Resectable Liver Carcinoma - Doctor's Guide, 3/31/04
• Combo Treatment for Liver Cancer Is Effective - WebMD, 3/30/04
• Chemoembolisation + Radio Frequency Ablation May Offers Durable Local Control for Liver Tumours - Doctor's Guide, 3/30/04
• Chemoembolization Plus Radiofrequency Ablation Effective for Local Control of Liver Cancer - Medscape, 3/29/04
• Interferon-Alpha May Be Safe, Effective In Preventing Hepatocellular Carcinoma Recurrence After Ablation Therapy - Doctor's Guide, 1/30/04
• Laser-Induced Thermotherapy May Be Better Than Surgery for Liver Metastases - Doctor's Guide, 12/5/03
• Chemotherapy Delivered Into Hepatic Artery Highly Effective for Liver Metastases - Doctor's Guide, 12/4/03
• Study Establishes Effectiveness of Radiofrequency Ablation for Treatment of Primary Liver Cancer - Doctor's Guide, 11/6/03
• Topical Testosterone Gel Appears to Benefit Patients Awaiting Liver Transplant - Doctor's Guide, 10/29/03
• Transarterial Chemoembolization Prepares Liver Metastases for Laser Tx - Medscape, 10/28/03
• Outpatient Combination Treatment Shrinks Liver Tumors To Acceptable Size For Laser Procedure - Doctor's Guide, 10/28/03
• Fatty Liver Increases Cancer Risk - Doctor's Guide, 3/27/03
• A New Approach For Un-Resectable Colorectal Liver Metastases - Doctor's Guide, 3/21/03
• Aggressive Therapy of Liver Metastases Appears Cost-Effective - Doctor's Guide, 12/5/02
• Pilot Study Suggests Photodynamic Therapy Effective for Liver Metastases - Doctor's Guide, 12/5/02
• New Ultrasound Technique Improves Differentiation of Benign and Malignant Liver Lesions - Doctor's Guide, 12/2/02
• Intra-Arterial Delivery System Localises Treatment of Hepatocellular Carcinoma - Doctor's Guide, 11/22/02
• Chemoembolization May Be Treatment of Choice in Liver Cancer Subgroup - Medscape, 11/6/02
• Effective Therapy Still Lacking For Resectable Hepatocellular Carcinoma - Doctor's Guide, 10/14/02
• Laparoscopic Resection Of Small Left Lateral or Anterior Segments of Right Liver Tumours Safe - Doctor's Guide, 7/16/02
• Chemoembolization Improves Survival in Liver Cancer - Medscape, 5/22/02
• Fotemustine Prolongs Survival in Patients with Liver Metastases from Ocular Melanoma - Doctor's Guide, 5/20/02
• Chemoembolisation Adds Survival Time In Untreatable Liver Cancer - Doctor's Guide, 5/20/02
• Environmental Factors Could Play Hypermethylation Role In Cancer - Doctor's Guide, 5/16/02
• Brachytherapy Demonstrates Promise in Tough-to-Treat Liver Cancer - Doctor's Guide, 2/4/02
• New Electrolysis Treatment For Liver Cancer Continues to Impress - Doctor's Guide, 11/8/01
• Hepatitis C Drug May Help Stop Liver Cancer Recurrence, Interferon Alpha, Given After Surgery, Shows Promise - WebMD, 5/30/01 - "The drug, called interferon alpha, appears to help prevent the return of liver cancer in people with hepatitis C who have had a tumor removed surgically"
• New Treatment, TheraSphere, May Be Welcome Alternative For Inoperable Liver Cancer - Doctor's Guide, 5/15/01 - "TheraSphere is a unique new targeted therapy that spares healthy tissue while providing radiation directly to liver tumors"
• Scientists Coax Liver Cells Into Growing On Silicon Chip - Intelihealth, 5/10/01
• Hepatic Artery Chemotherapy Improves Survival In Patients With Liver Metastases - Doctor's Guide, 5/19/00
• Chemotherapy Delivered Directly To Liver Tumours Can Extend Lives - Doctor's Guide, 3/22/99
• New Radiation Procedure Targets Liver Cancer - Doctor's Guide, 6/1/98