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Home > Anti-aging Research > Schisandra

Schizandra (Schisandra chinensis)

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  • Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration - Nutrients. 2020 Mar 25 - "Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline" - [Nutra USA] - See Schizandra at Amazon.com and Schizandra at iHerb.com and vitamin C products at Amazon.com and vitamin C at iHerb.com.
  • Anti-Aging Effects of Schisandrae chinensis Fructus Extract: Improvement of Insulin Sensitivity and Muscle Function in Aged Mice - Evid Based Complement Alternat Med. 2019 Nov 3;2019 - "Schisandrae chinensis Fructus has a long history of medicinal use as a tonic, a sedative, and an antitussive drug ... Insulin sensitivity was lower at 20 months of age than at 16 months of age; however, the decrease in insulin sensitivity was less in SFe-fed mice. SFe supplementation also appeared to improve glucose tolerance. Body weight gain was lower in SFe-fed mice than in mice fed the control diet. Body fat mass was lower and the lean mass was higher in SFe-fed mice. In addition, the grip strength was enhanced in SFe-fed mice. Histological analysis of the tibialis anterior muscle showed that the size of myofiber and slow-twitch red muscle was increased by SFe supplementation. The expression of proteins related to muscle protein synthesis such as phospho-Erk1 and phospho-S6K1 was increased by SFe supplementation. The mRNA expression of genes related to myogenesis and their encoded proteins such as MyoD, Myf5, MRF4, myogenin, and myosin heavy chain, was increased, whereas that of genes related to muscle degradation, such as atrogin-1, MuRF-1, and myostatin, were decreased relative to control mice. These results suggest that SFe supplementation might have beneficial effects for the improvement of insulin sensitivity and inhibition of muscle loss that occur with aging"
  • Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain-derived neurotrophic factor - Phytother Res. 2019 Aug 30 - "sleep deprivation (SD) and Schisandrae Chinensis Fructus (SCF) ... chronic unpredictable mild stress (CUMS) ... These results indicated that the antidepressant-like effect of SCF in the CUMS depends on the activation of BDNF and the modulation of TrkB/CREB/ERK and PI3K/AKT/GSK3β/mTOR signaling cascades, and SD (12 hr) shared a common etiology consisting of complex bidirectional interactions with SCF"
  • Schizandrin ameliorates ovariectomy-induced memory impairment and exhibits antioxidant and synaptic transmission properties - Br J Pharmacol. 2015 Jan 9 - "SCH improves memory activity and the potential mechanisms in OVX rats may include reducing the loss of hippocampal NADPH-d positive neurons, increasing antioxidation, and improving synaptic transmission that is possible involving from enhancing cholinergic function. Overall, our findings demonstrate that SCH could provide a potential therapeutic role for menopause cognitive dysfunction"