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Home > Health Conditions > Lung Cancer

Lung Cancer, lung injury & emphysema

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  • Inhibitory Effect and Mechanism of Ursolic Acid on Cisplatin-Induced Resistance and Stemness in Human Lung Cancer A549 Cells - Evid Based Complement Alternat Med 2023 Apr 14; - "The survival rate of lung cancer patients remains low largely due to chemotherapy resistance during treatment, and cancer stem cells (CSCs) may hold the key to targeting this resistance. Cisplatin is a chemotherapy drug commonly used in cancer treatment, yet the mechanisms of intrinsic cisplatin resistance have not yet been determined because lung CSCs are hard to identify ... When UA was applied to the cisplatin-resistant cells, levels of the pluripotent stem cell transcription factors were restrained by the inhibition of the Jak2/Stat3 signaling pathway, which reduced the enrichment of tumor stem cells, and in turn, reversed cisplatin resistance in lung cancer cells. Hence, as a potential antitumor drug, UA may be able to inhibit the enrichment of the lung CSC population by inhibiting the activation of the Jak2-Stat3 pathway and preventing the resistance of lung cancer cells to cisplatin" - See ursolic acid at Amazon.com.
  • Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non-small cell lung cancer - Phytother Res 2023 Apr - "Lung cancer is the leading cause of cancer-related death. In particular, non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. Due to tumor resistance and the toxicity of chemotherapeutic agents, it is increasingly critical to discover novel, potent antitumorigenic drugs for treating NSCLC. Lutein, a carotenoid, has been reported to exert toxic effects on cells in several tumor types ... Mechanistically, lutein exerted antitumorigenic effects by inducing DNA damage and subsequently activating the ATR/Chk1/p53 signaling pathway in A549 cells. In vivo, lutein impeded tumor growth in mice and prolonged their survival. In conclusion, our findings demonstrate the antitumorigenic potential of lutein and reveal its molecular mechanism of action, suggesting that lutein is a promising candidate for clinical NSCLC treatment" - See lutein at Amazon.com.
  • Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53 - Evid Based Complement Alternat Med 2023 Feb 13 - "Our findings point to the possibility that HO-3867 might be employed as a therapeutic agent for treating NSCLC" - See curcumin at Amazon.com.
  • Garlic Extract Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells Via Endoplasmic Reticulum Stress Pathway - Evid Based Complement Alternat Med 2023 Feb 6 - "To investigate the effect of garlic extract (GE) on the proliferation and apoptosis of cell lines A549 and H1299 in lung cancer (LC) ... GE could exert toxic effects on A549 and H1299 cells, inhibit cell proliferation, promote apoptosis, and attenuate cell migration. Meanwhile, it might induce apoptosis of A549 and H1299 cells through the caspase signal pathway, which is positively correlated with the mass action concentration and is expected to be a new drug for LC treatment" - See garlic supplements at Amazon.com.
  • The Mechanism of Quercetin in the Treatment of Lung Squamous Cell Carcinoma Based on a Protein-Protein Interaction Network - Evid Based Complement Alternat Med 2022 Dec 27 - "Our study demonstrates that QR not only inhibits the proliferation of LUSC but also affects the invasion and metastasis of LUSC. After downloading and analyzing the TCGA database, 2150 differentially expressed genes were identified. PLK1, CDC20, and BUB1B were identified using enrichment analysis, topological network analysis, cluster analysis, and molecular docking screening. Subsequent experiments showed that QR could interfere with the cell cycle and downregulate the expression of the target gene PLK1 at the protein level ... We found that QR not only inhibits the proliferation, migration, and invasion but also blocks the cell cycle progression of LUSC. QR downregulated the expression of the LUSC target gene PLK1 at the protein level" - See quercetin at Amazon.com.
  • The Pharmacological Mechanism of Curcumin against Drug Resistance in Non-Small Cell Lung Cancer: Findings of Network Pharmacology and Bioinformatics Analysis - Evid Based Complement Alternat Med 2022 Oct 14 - "Curcumin in combination with immunotherapy, chemotherapy, or targeted drugs has the potential to be effective for drug-resistant NSCLC" - See curcumin at Amazon.com.
  • Astaxanthin ameliorates lipopolysaccharide-induced acute lung injury via inhibition of inflammatory reactions and modulation of the SOCS3/JAK2/STAT3 signaling pathways in mice - Food Funct 2022 Oct 24 - "Acute lung injury (ALI) is a systemic inflammatory process. A large number of studies have shown that astaxanthin (ASTA) has strong anti-inflammatory effects and almost non-toxic side effects. The purpose of this study was to explore the effect of ASTA on lipopolysaccharide (LPS)-induced ALI in mice and its underlying mechanism. The result showed that compared with the LPS group, the expression levels of the respiratory resistance (Re), inspiratory resistance (Ri), dynamic lung compliance (Cdyn), wet/dry weight (W/D) ratio, albumin (BA/SA) ratio and myeloperoxidase (MPO) activity in the ASTA pretreatment group were significantly reduced, and total cell, neutrophil and macrophage counts were significantly decreased ... The results showed that ASTA had a protective effect on LPS-induced acute lung injury in mice, and its protective mechanism was through activating the SOCS3/JAK2/STAT3 signaling pathway, promoting Treg cell differentiation and reducing inflammatory reactions and Th17 cell differentiation, which provided a theoretical basis for the clinical treatment of ALI" - See astaxanthin at Amazon.com.
  • Ginsenoside Rg1 Suppresses Non-Small-Cell Lung Cancer via MicroRNA-126-PI3K-AKT-mTOR Pathway - Evid Based Complement Alternat Med 2022 Jul 1 - "As one of the most common cause of cancer death in the world, lung cancer causes approximately 1.6 million deaths annually. Among them, NSCLC accounts for approximately 85% of patients in whole lung cancer patients. Ginsenoside Rg1 has been confirmed to play an important role in various diseases including cancer. As one of miRNAs, miR-126 closely involves in pathogenesis of the several types of cancers including colorectal, prostate, bladder and gastric cancer, and so on ... Inhibition of Ginsenoside Rg1 on growth of lung cancer cells was through miR-126 and mTOR. Thus, the present study confirmed that Ginsenoside Rg1 remarkably inhibit lung cancer, which is through microRNA-126-PI3K-AKT-mTOR pathway" - See ginseng at Amazon.com.
  • Curcumin Increased the Sensitivity of Non-Small-Cell Lung Cancer to Cisplatin through the Endoplasmic Reticulum Stress Pathway - Evid Based Complement Alternat Med 2022 Jun 17 - "Non-small-cell lung cancer (NSCLC) is one of the most lethal cancers. Although cisplatin-based chemotherapies have been regarded as a promising treatment approach, cisplatin resistance still remains one of the major clinical challenges. Curcumin, a naturally occurring polyphenol, has been proved to increase chemotherapeutic efficiency of NSCLC cells ... Curcumin can increase the sensitivity of NSCLC to cisplatin through an ER stress pathway and thus can be served as one of the molecular targets for overcoming the cisplatin resistance" - See curcumin at Amazon.com.
  • Exploration of Potential Targets and Mechanisms of Fisetin in the Treatment of Non-Small-Cell Lung Carcinoma via Network Pharmacology and In Vitro Validation - Evid Based Complement Alternat Med 2022 Jun 13 - "The morbidity and fatality rates of non-small-cell lung cancer (NSCLC) were high, although a combination of multiple treatments was used. Fisetin, a small flavonoid compound, had shown anticancer activities. Thus, we aimed at exploring the mechanisms of Fisetin in the treatment of NSCLC ... The present study found a series of novel targets and pathways for Fisetin treating NSCLC" - See fisetin at Amazon.com.
  • Anti-invasive and anti-metastatic activity of capsaicin and natural capsaicin-like compounds in lung adenocarcinoma - FASEB J 2022 May - "Lung adenocarcinoma (LAC) accounts for about 65% of all non-small cell lung cancer (NSCLC) cases. A considerable proportion of LAC patients present (in the clinic) with local and distant metastasis at the time of their diagnosis. One of the earliest events of the metastatic pathway is the invasion of malignant cells through the surrounding extracellular basement membrane into the neighboring blood vessels and lymph nodes ... Capsaicin is the pungent ingredient of chili peppers. Published reports have revealed that capsaicin inhibits the invasion and metastasis of several types of human cancers including melanoma, prostate cancer, and cholangiosarcoma ... capsaicin inhibits the invasion of human LAC cells via the TRPV6 receptor and the tyrosine phosphatase activity pathway" - See capsicum at Amazon.com.
  • Quercetin Inhibits the Epithelial to Mesenchymal Transition through Suppressing Akt Mediated Nuclear Translocation of β-Catenin in Lung Cancer Cell Line - Nutr Cancer 2021 Aug 2 - "Lung cancer is a first leading cause of cancer related death worldwide. Quercetin (QUE) has chemo-preventive effect against a variety of cancers .... Our results suggest that QUE can inhibit the metastatic potential in lung cancer by altering the Akt/MAPK/β-catenin signaling pathway and inhibiting the nuclear translocation of β-catenin" - See quercetin at Amazon.com and iHerb.
  • Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer - Cancer Lett 2021 May 27 - "Upregulated expression of immune checkpoint molecules correlates with exhausted phenotype and impaired function of cytotoxic T cells to evade host immunity. By disrupting the interaction of PD-L1 and PD1, immune checkpoint inhibitors can restore immune system function against cancer cells. Growing evidence have demonstrated apigenin and luteolin, which are flavonoids abundant in common fruits and vegetables, can suppress growth and induce apoptosis of multiple types of cancer cells with their potent anti-inflammatory, antioxidant and anticancer properties ... Luteolin and apigenin significantly inhibited lung cancer cell growth, induced cell apoptosis, and down-regulated the IFN-γ-induced PD-L1 expression by suppressing the phosphorylation of STAT3. Both luteolin and apigenin showed potent anti-cancer activities in the H358 xenograft and Lewis lung carcinoma model in vivo, and the treatment with monoclonal PD1 antibody enhanced the infiltration of T cells into tumor tissues. Apigenin exhibited anti-tumor activity in Genetically engineered KRASLA2 mice. In conclusion, both apigenin and luteolin significantly suppressed lung cancer with KRAS mutant proliferation, and down-regulated the IFN-γ induced PD-L1 expression. Treatment with the combination of PD-1 blockade and apigenin/luteolin has a synergistic effect and might be a prospective therapeutic strategy for NSCLC with KRAS-mutant" - See luteolin at Amazon.com.
  • Association Between Dietary Sodium, Potassium Intake and Lung Cancer Risk - Medscape, 4/29/21 - "Appropriate intake of potassium has a protective effect against lung cancer, while high consumption of sodium is associated with an increased risk of lung cancer" - See potassium citrate at Amazon.com.
  • Trilobatin Induces Apoptosis and Attenuates Stemness Phenotype of Acquired Gefitinib Resistant Lung Cancer Cells via Suppression of NF-κB Pathway - Nutr Cancer 2021 Apr 16 - "Trilobatin is a common type of flavonoids compounds derived from Lithocarpus polystachyus Rehd leaves. Previous report suggests that trilobatin was potentially involved in pro-and anticancer, antioxidative and anti-hyperglycemic activities. Here, we investigated the anticancer efficiency of trilobatin on gefitinib resistant lung cancer cells ... trilobatin inhibits proliferation of gefitinib resistant lung cancer cells. In addition, the proportions of apoptotic cells were increased along with down-regulated expression levels of Bcl-2 and mitochondrial Cytochrome C while up-regulated Bax, Cleaved Caspase-3, -9, and cytosolic Cytochrome C expression. Moreover, trilobatin decreased tumor sphere formation and expression levels of multiple stemness markers (ALDH1, CD133, Nanog, and ABCG2) in gefitinib resistant lung cancer cells. Furthermore, investigation of the mechanism indicated that trilobatin suppressed activity of NF-κB via decreasing constitutive phosphorylation of NF-κB p65 and IκB-α in gefitinib resistant lung cancer cells. All these results indicate that trilobatin induces apoptosis and attenuates stemness phenotype of gefitinib resistant lung cancer cells, involved with, or partly, the suppression of NF-κB activity" - See flavonoids at Amazon.com.
  • Associations of Omega-3 Fatty acids with Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults - Am J Epidemiol 2020 Aug 17 - "Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, attenuates interstitial lung disease (ILD) in experimental models but human studies are lacking. We examined associations of circulating levels of DHA, and other polyunsaturated fatty acids, with hospitalization and death due to ILD over 12 years in the Multi-Ethnic Study of Atherosclerosis (MESA, n=6,573). We examined cross-sectional associations with CT lung abnormalities in MESA (2000-2012), Framingham Heart Study (2005-2011), and Age Gene/Environment Susceptibility (2002-2006) Study (total n=10,193). Polyunsaturated fatty acid levels were from fasting blood samples and extracted from plasma phospholipids (MESA and Age Gene/Environment Susceptibility) or red blood cell membranes (Framingham Heart Study). Higher DHA levels were associated with a lower risk of hospitalizations due to ILD (adjusted rate ratio 0.69 per standard deviation increment (95% CI 0.48, 0.99) and a lower rate of death due to ILD (adjusted hazard ratio 0.68 per standard deviation increment, 95% CI 0.47, 0.98). Higher DHA was associated with less interstitial lung abnormalities on CT (pooled adjusted odds ratio 0.65 per natural log increment; 95% CI 0.46, 0.91). Higher DHA levels were associated with a lower risk of hospitalization and death due to ILD and less lung abnormalities on CT in a meta-analysis of population-based cohorts." - [Nutra USA] - See docosahexaenoic acid at Amazon.com.
  • Fluvastatin inhibits HMG-CoA reductase and prevents non-small cell lung carcinogenesis - Cancer Prev Res (Phila). 2019 Sep 25 - "Lung cancer is the leading cause of cancer death worldwide ... our findings suggest that fluvastatin might be promising chemopreventive or potential therapeutic drug against NSCLC tumorigenesis, providing hope for rapid clinical translation"
  • Magnesium intake and lung cancer risk: A systematic review and meta-analysis - Int J Vitam Nutr Res. 2019 Jul 15:1-8 - "The pooled relative risk (RR) indicated a significant association between lung cancer incidence and magnesium intake (RR = 0.88, 95% CI = 0.79 to 0.98; p = 0.018). To investigate the cause of heterogeneity of these studies (I2 = 75.8%, p < 0.001), we performed a subgroup analysis which was affected by the mean dose of magnesium intake, where doses of magnesium intake lower than 300 mg/d significantly decreased lung cancer risk (RR = 0.83, 95% CI = 0.70 to 0.99; p = 0.034). Increasing magnesium intake doses to over 300 mg/d did not reduce the incidence of lung cancer (RR = 0.89, 95% CI = 0.78 to 1.01; p = 0.076). Our meta-analysis suggests that magnesium intake of less than 300 mg/d may have protective effects in lung cancer." - See magnesium supplements at Amazon.com.
  • A grape constituent protects against cancer - Science Daily, 10/3/18 - "This 26 week long study contained four groups of mice. The first one, the control, received neither carcinogen nor resveratrol treatment. The second received only the carcinogen, the third received both the carcinogen and the treatment, and the fourth received only the treatment. "We observed a 45% decrease in tumor load per mouse in the treated mice. They developed fewer tumors and of smaller size than untreated mice," says Muriel Cuendet. When comparing the two groups that were not exposed to carcinogen, 63% of the mice treated did not develop cancer, compared to only 12.5% of the untreated mice. "Resveratrol could therefore play a preventive role against lung cancer," she continues" - See resveratrol products at Amazon.com.
  • Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer - Am J Med Sci. 2017 Sep;354(3):246-251 - "Metformin (MF), a diabetic drug, has antineoplastic activity as adjuvant therapy for breast cancer and prostate cancer. MF is thought to work via inhibition of mammalian target of rapamycin and activation of p53 and liver kinase B1 via adenosine 5'-monophosphate-activated protein kinase ... For CC, the MF group noted fewer deaths (48% versus 76%, P < 0.001), recurrences (4% versus 19%, P = 0.002), metastases (23% versus 46%, P = 0.001), better 5-year survival rates (57% versus 37%, P = 0.004), overall survival years (5.7 versus 4.1, P = 0.007) and greater carcinoembryonic antigen decrease (72% versus 47%, P = 0.015). MF was associated with improved 5-year survival rates (29% versus 15%, P = 0.023) and overall survival years (3.4 versus 1.8, P < 0.001) in LC" - See metformin at The Antiaging Store.
  • Resveratrol may be an effective intervention for lung aging - Science Daily, 2/22/17 - "Resveratrol (RSL) ... In healthy young adults, breathing is an essential, efficient process, but natural aging of the lung occurs at a steady and irreversible rate, as measured by a decline in lung function. This natural deterioration leads to a significantly reduced quality of life, over a time frame dependent on genetic and environmental factors. Although some available therapies can ameliorate symptoms, aging-related lung failure is generally irreversible and is accompanied by high rates of morbidity and mortality due to increased disease risk, including development of COPD, with accompanying emphysema and chronic bronchitis ... The research team found that inhaled, prophylactic resveratrol treatments can slow the rate of lung function decline, alveolar enlargement and alveolar epithelial type 2 cell DNA damage that occurs in the early stages of lung aging. They concluded that administration of resveratrol directly to the lungs may be an effective intervention for lung aging, which is a significant risk factor for development of chronic lung disease" - I would think that by taking it orally it would make its way into the cells of the lungs although at a lower concentration.  See Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.
  • Beta-cryptoxanthin, a carotenoid, inhibits nicotine-linked lung cancer development in mice - Science Daily, 11/1/16 - "The team calculated that these doses are equivalent to approximately 0.087 and 0.87 milligrams of daily BCX intake in humans (eating a tangerine or cup of sweet red peppers per day, for example) ... At the end of the experimental period, mice fed BCX developed on average 50 to 60 percent fewer tumors than mice not fed BCX ... The team's findings corroborate human epidemiological studies that have found an association between higher BCX intake and lower risk of lung cancer in current smokers from North America and Asian countries"
  • Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications - Nutrients. 2015 Nov 11 - "he pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768" - See carotenoids at Amazon.com.
  • Synergistic effects of metformin in combination with EGFR-TKI in treatment of patients with advanced non-small cell lung cancer and type 2 diabetes - Cancer Lett. 2015 Sep 1 - "epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment ... Metformin use is associated with improved survival and delayed onset of acquired resistance to EGFR-TKI" - See metformin at The Antiaging Store.
  • Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer - Cancer Lett. 2014 Nov 18 - "Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer" - See curcumin products at Amazon.com.
  • Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice - Cancer Prev Res (Phila). 2014 Nov 17 - "Dietary administration of DIM (10 µmol/g diet or 2460 ppm) to mice treated with NTCU plus LPS reduced the incidence of LSCC by 2-fold, suppressed activation/expression of proinflammatory and procarcinogenic proteins and NF-κB- and STAT3-DNA binding, but not the expression of cytokines and p53. This study highlights the potential significance of our mouse model to identify promising drugs or dietary agents for the chemoprevention of human LSCC and that DIM is a very good candidate for clinical lung cancer chemoprevention trials" - See diindolylmethane at Amazon.com.
  • Vitamin E intake and the lung cancer risk among female nonsmokers: A report from the Shanghai Women's Health Study - Int J Cancer. 2014 Jun 11 - "In summary, dietary tocopherol intake may reduce the risk of lung cancer among female non-smokers, however supplements may increase lung adenocarcinoma risk"
  • Fish Consumption and Lung Cancer Risk: Systematic Review and Meta-Analysis - Nutr Cancer. 2014 Apr 7 - "The pooled results from all studies indicated that high fish consumption was significantly associated with a decreased risk of lung cancer (pooled RR: 0.79; 95% CI: 0.69-0.92)" - See fish oil supplements at Amazon.com.
  • Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers - Int J Cancer. 2014 Mar 13 - "Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers"
  • Luteolin is effective in the non-small-cell lung cancer model with L858R/T790M EGFR mutation and erlotinib resistance - Br J Pharmacol. 2014 Jan 29 - "We found that luteolin exerted remarkable anti-tumorigenic effects on EGFR L858R/T790M mutation and erlotinib-resistant NSCLC both at cell and animal levels. Mechanistically, luteolin induced EGFR degradation through inhibiting the association of Hsp90 and mutant EGFR and therefore obviously prevented PI3K/AKT/mTOR signalling and led to NSCLC cell apoptosis" - See luteolin at Amazon.com.
    • Luteolin - Wikipedia - "Luteolin is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance"
  • Diabetes drug with chemo, radiation may improve outcomes for lung cancer - Science Daily, 10/23/13 - "Treating aggressive lung cancer with the diabetes drug metformin along with radiation and chemotherapy may slow tumor growth and recurrence ... Metformin, the most-widely used drug for type-2 diabetes, has been shown to have anti-cancer effects on a number of cancers, including prostate and colon" - See metformin at The Antiaging Store.
  • Vitamin D intake and lung cancer risk in the Women's Health Initiative - Am J Clin Nutr. 2013 Aug 21 - "Prospective cohort data from 128,779 postmenopausal women, including 1771 incident lung cancers in the Women's Health Initiative (Clinical Trials and Observational Study) 1993-2010, were analyzed ... No significant association was observed overall. Among never smokers, a total vitamin D intake ≥400 IU/d was significantly associated with lower risks of lung cancer (HR: 0.37; 95% CI: 0.18, 0.77 for ≥800 compared with <100 IU/d; P-trend = 0.01). No significant effect modification of total vitamin A intake on the association between total vitamin D intake and lung cancer was found. However, the Calcium/Vitamin D Trial active intervention was significantly associated with a lower lung cancer risk only among women with a vitamin A intake <1000 μg/d retinol activity equivalents (HR: 0.69" - See vitamin D at Amazon.com.
  • Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells - Phytother Res. 2013 Aug 13 - "Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association with the reduction in ikappaB level may be one of such potential mechanisms. It is known that curcumin inhibits the inducible activation of NFkappaB at least in part by sustaining ikappaB expression level ... We found that erlotinib and curcumin augmentatively reduced cell viability ... Furthermore, coadministration of erlotinib and/or curcumin augmentatively attenuated the growth of PC9 tumors in mice" - See curcumin products at Amazon.com.
  • Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population - Cancer Prev Res (Phila). 2013 Jul;6(7):711-8 - "Epidemiologic data were collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls ... raw garlic consumption of 2 times or more per week is inversely associated with lung cancer (OR = 0.56; 95% CI, 0.44-0.72) with a monotonic dose-response relationship" - See garlic supplements at Amazon.com.
  • Silibinin reverses drug resistance in human small-cell lung carcinoma cells - Cancer Lett. 2013 Jul 20 - "The possible synergistic relationship between silibinin and chemotherapy drugs was determined by exposure of VPA17 cells to 1:1 ratios of their respective IC50 values, with serial dilutions at 0.25-2.0 x IC50 and calculation of the combination index (CI). Silibinin and etoposide showed synergism (CI = 0.46 at ED50), as did silibinin and doxorubicin (CI = 0.24 at ED50). These data indicate that in SCLC, silibinin is pro-apoptotic, reverses MDR and acts synergistically with chemotherapy drugs. Silibinin, a non-toxic natural product may be useful in the treatment of drug-resistant SCLC" - See silymarin at Amazon.com.
  • Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells - Biol Pharm Bull. 2013;36(6):944-951 - "The herbal flavonoid quercetin inhibits the growth of various cancer cells, but how it affects human cancer cells, particularly lung cancer cells, is unclear ... Taken together, these findings suggest that quercetin may be useful in the prevention and therapy of NSCLC" - See quercetin at Amazon.com.
  • Chemopreventive and anti-cancer efficacy of silibinin against growth and progression of lung cancer - Nutr Cancer. 2013;65 Suppl 1:3-11 - "Successful studies conducted so far, have established that silibinin is effective both alone and in combination with other agents (e.g., chemotherapeutic and epigenetic agents) in significantly inhibiting the growth of lung cancer cells" - See silymarin at Amazon.com.
  • Differential Effect of Grape Seed Extract against Human Non-small-Cell Lung Cancer Cells: The Role of Reactive Oxygen Species and Apoptosis Induction - Nutr Cancer. 2013;65 Suppl 1:44-53 - "GSE suppressed growth and induced apoptotic death in NSCLC cells irrespective of their k-Ras status" - See Jarrow Formulas OPCs + 95 at Amazon.com.
  • Intakes of Fruits, Vegetables, and Related Vitamins and Lung Cancer Risk: Results from the Shanghai Men's Health Study (2002-2009) - Nutr Cancer. 2013 Jan;65(1):51-61 - "investigated the association of intakes of fruits, vegetables, dietary vitamins A and C, and folate with lung cancer risk among 61,491 adult Chinese men who were recruited into the Shanghai Men's Health Study, a population-based, prospective cohort study. Baseline dietary intake was assessed through a validated food frequency questionnaire during in-home visits ... median follow-up of 5.5 yr ... Intakes of green leafy vegetables, β-carotene-rich vegetables, watermelon, vitamin A, and carotenoids were inversely associated with lung cancer risk; the corresponding HR (95% CI) comparing the highest with the lowest quartiles were 0.72 (0.53-0.98), 0.69 (0.51-0.94), 0.65 (0.47-0.90), 0.63 (0.44-0.88), and 0.64 (0.46-0.88). Intake of all fruits and vegetables combined was marginally associated with lower risk. Our study suggests that the consumption of carotenoid-rich vegetables is inversely associated with lung cancer risk" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Diabetes drug could hold promise for lung cancer patients - Science Daily, 1/28/13 - "Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases could also work against cancer ... phenformin, a derivative of the widely-used diabetes drug metformin, decreased the size of lung tumors in mice and increased the animals' survival ... Metformin and phenformin both inhibit mitochondria; however, phenformin is nearly 50 times as potent as metformin ... The Food and Drug Administration took phenformin off the market in 1978 due to a high risk of lactic acid buildup in patients with compromised kidney function, which is not uncommon among diabetics but less of an issue for most cancer patients" - See metformin at The Antiaging Store.
  • The risk of lung cancer related to dietary intake of flavonoids - Nutr Cancer. 2012 Oct;64(7):964-74 - "Overall, total flavonoid intake was not associated with lung cancer risk, the effect being similar regardless of sex and smoking level. However, low flavonoid intake from food, but not from beverages, was associated with an increased risk. The adjusted ORs (95% CIs) comparing the highest vs. the lowest quartiles of intake were 0.63 (0.47-0.85) for total flavonoids, 0.82 (0.61-1.11) for anthocyanidins, 0.67 (0.50-0.90) for flavan-3-ols, 0.68 (0.50-0.93) for flavones, 0.62 (0.45-0.84) for flavonols, and 0.70 (0.53-0.94) for flavanones. An inverse association with total flavone and flavanone intake was observed for squamous cell carcinoma but not adenocarcinoma. In conclusion, low flavonoid intake from food may increase lung cancer risk" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT - Eur J Clin Nutr. 2012 Jan 11 - "(2.02 g eicosapentaenoic acid+0.92 g docosahexaenoic acid/day) or an isocaloric control supplement ... The intervention group reported significantly higher on the quality of life parameters, physical and cognitive function (B=11.6 and B=20.7, P<0.01), global health status (B=12.2, P=0.04) and social function (B=22.1, P=0.04) than the control group after 5 weeks. The intervention group showed a higher Karnofsky Performance Status (B=5.3, P=0.04) than the control group after 3 weeks. Handgrip strength did not significantly differ between groups over time. The intervention group tended to have a higher physical activity than the control group after 3 and 5 weeks (B=6.6, P=0.04 and B=2.5, P=0.05)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Milk thistle extract stops lung cancer in mice, study shows - Science Daily, 11/15/11 - "Compared to these multi-million dollar drugs, naturally-occurring silibinin blocked not only the expression of COX2 and iNOS, but also the migration of existing lung cancer cells" - See silymarin at Amazon.com.
  • Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies - Am J Clin Nutr. 2011 Nov 9 - "A total of 11 epidemiologic studies that consisted of 8 case-control and 3 prospective cohort studies were included. A significantly inverse association was shown between soy intake and lung cancer with an overall RR of 0.77 (95% CI: 0.65, 0.92). Findings were slightly different when analyses were restricted to 5 high-quality studies (RR: 0.70; 95% CI: 0.45, 0.99). In a subgroup meta-analysis, a statistically significant protective effect of soy consumption was observed in women (RR: 0.79; 95% CI: 0.67, 0.93), never smokers (RR: 0.62; 95% CI: 0.51, 0.76), and Asian populations (RR: 0.86; 95% CI: 0.74, 0.98)"
  • Inhibitory Effect of Vitamin C in Combination With Vitamin K3 on Tumor Growth and Metastasis of Lewis Lung Carcinoma Xenografted in C57BL/6 Mice - Nutr Cancer. 2011 Sep 2 - "Vit CK3 restored the body weight of tumor-bearing mice to the level of tumor-free mice ... These results demonstrate that vit CK3 inhibits primary tumor growth and exhibits antimetastastic potential in vivo through attenuated tumor invasion and proliferation" - See vitamin C products at Amazon.com and vitamin K at Amazon.com.
  • Meat Consumption and Risk of Lung Cancer Among Never-Smoking Women - Nutr Cancer. 2011 Jul 20 - "Among these never smokers, fruit and vegetable intake were inversely associated with lung cancer risk. Seventy-two percent of meat consumed was white meat (chicken or fish). Meat consumption overall was inversely associated with lung cancer [adjusted odds ratio (OR), 0.88, 0.59 for second, third tertiles, P (trend) = .012]. An inverse relationship between fish consumption and lung cancer (adjusted OR, 0.81, 0.47 for 2nd, 3rd tertiles, P (trend) < .001) was observed. No association was seen between consumption of processed meats and lung cancer, nor between dietary heterocyclic amines and lung cancer. Our data suggest that fish consumption may be protective against lung cancer in never smokers"
  • Soy increases radiation's ability to kill lung cancer cells, study shows - Science Daily, 4/1/11 - "These natural soy isoflavones can sensitize cancer cells to the effects of radiotherapy, by inhibiting survival mechanisms which cancer cells activate to protect themselves ... At the same time, soy isoflavones can also act as antioxidants in normal tissues, which protect them against unintended damage from the radiotherapy ... soy isoflavones increase killing of cancer cells by radiation via blocking DNA repair mechanisms, which are turned on by the cancer cells to survive the damage caused by radiation ... Researchers used a formulation consisting of the three main isoflavones found in soybeans, including genistein, daidzein and glycitein ... Previously, researchers had found that pure genistein demonstrated antitumor activity in human NSCLC cell lines and enhanced the effects of EGFR-tyrosine kinase inhibitors. This study showed that the soy mixture had an even greater antitumor effect than pure genistein" - See soy isoflavones at Amazon.com.
  • Vitamin D linked to lung cancer survival, study suggests - Science Daily, 3/1/11 - "Recent research suggests vitamin D may be able to stop or prevent cancer. Now, a new study finds an enzyme that plays a role in metabolizing vitamin D can predict lung cancer survival ... Levels of the enzyme, called CYP24A1, were elevated as much as 50 times in lung adenocarcinoma compared with normal lung tissue. The higher the level of CYP24A1, the more likely tumors were to be aggressive. About a third of lung cancer patients had high levels of the enzyme. After five years, those patients had nearly half the survival rate as patients with low levels of the enzyme ... Researchers then linked this to how CYP24A1 interacts with calcitriol, the active form of vitamin D" - See vitamin D at Amazon.com.
  • Plasma isoflavones and the risk of lung cancer in women: A nested case-control study in Japan - Cancer Epidemiol Biomarkers Prev. 2011 Jan 14 - "After exclusion of 20 lung cancer cases diagnosed in the first 3 years after blood collection, an inverse association was found between plasma genistein concentration and lung cancer risk. The multivariate-adjusted OR (95% CI) of lung cancer in the highest quintile of plasma genistein concentration as compared with that in the lowest quintile was 0.31 (0.12, 0.86) (P for trend = 0.085). Other isoflavones and total isoflavones were not associated with a significant decrease in the risk of lung cancer" - See genistein at Amazon.com.
  • Metformin Might Prevent Colorectal, Lung Cancers - Medscape, 9/3/10 - "The chance observation that diabetes patients taking metformin have a 40% reduced risk for cancer triggered intense research interest in this old off-patent drug ... After about 10% of the mouse lifespan — about 12 weeks — with the highest dose in the drinking water, we found a 33% reduction in tumor multiplicity and a 34% reduction in tumor size in the mice. In mice that did not get metformin, 100% got tobacco carcinogen-induced lung tumors ... metformin might prevent tumors by reducing levels of insulin and IGF-1" - See my Insulin and Aging page.  There are a lot of studies pointing toward insulin being a major cause of aging and caner.  See metformin at The Antiaging Store.
  • Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway - Biochem Biophys Res Commun. 2010 Jul 10 - "Curcumin extracted from the rhizomes of C. longa L has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the antitumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186 * in A549/DDP. In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186 * may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin" - See curcumin products at Amazon.com.
  • Higher levels of vitamin B6, common amino acid associated with lower risk of lung cancer - Science Daily, 6/15/10 - "Our results suggest that above-median se­rum measures of both B6 and methionine, assessed on average 5 years prior to disease onset, are associated with a reduction of at least 50 percent on the risk of developing lung cancer. An additional association for se­rum levels of folate was present, that when combined with B6 and methionine, was associated with a two-thirds lower risk of lung cancer"
  • Multivitamins may cut lung cancer risk in smokers - Nutra USA, 1/13/10 - "It impressively shows, for example, that supplements containing beta-carotene, conceivably increasing the risk of lung cancer in heavy smokers when taken in extremely high doses over years, have the potential to reduce cancer risk even in smokers ... People who ate at least 12 servings of green leafy vegetables per month had a 17 per cent lower risk of methylation, while a daily folate intake of at least 750 micrograms was associated with a 16 per cent lower risk ... Current multivitamin users had a 43 per cent lower risk of gene methylation, added the researchers"
  • Green Tea May Cut Smokers' Lung Cancer Risk - WebMD, 1/12/10 - "Overall, the smokers and nonsmokers who didn't drink green tea had a more than five times greater risk of lung cancer compared to those who had at least a cup of green tea" - See green tea extract at Amazon.com.
  • Fish Oil Supplementation Inhibits NNK-Induced Lung Carcinogenesis in the A/J Mouse - Nutr Cancer. 2009;61(5):663-9 - "fish oil supplementation was able to decrease lung tumor prevalence by 78% and 80% compared to groups receiving soybean oil and corn oil supplementation, respectively" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Human Lung Tumors Destroy Anti-cancer Hormone Vitamin D, Pitt Researchers Find - Science Daily, 4/20/09 - "Human lung tumors have the ability to eliminate Vitamin D, a hormone with anti-cancer activity"
  • Green tea, black tea consumption and risk of lung cancer: A meta-analysis - Lung Cancer. 2009 Jan 5 - "For green tea, the summary RR indicated a borderline significant association between highest green tea consumption and reduced risk of lung cancer (RR=0.78, 95% CI=0.61-1.00). Furthermore, an increase in green tea consumption of two cups/day was associated with an 18% decreased risk of developing lung cancer (RR=0.82, 95% CI=0.71-0.96). For black tea, no statistically significant association was observe through the meta-analysis (highest versus non/lowest, RR=0.86, 95% CI=0.70-1.05; an increment of two cups/day, RR=0.82, 95% CI=0.65-1.03). In conclusion, our data suggest that high or an increase in consumption of green tea but not black tea may be related to the reduction of lung cancer risk" - See green tea extract at Amazon.com.
  • Common Food Additive Found To Increase Risk And Speed Spread Of Lung Cancer - Science Daily, 12/29/08 - "a diet high in inorganic phosphates, which are found in a variety of processed foods including meats, cheeses, beverages, and bakery products, might speed growth of lung cancer tumors and may even contribute to the development of those tumors in individuals predisposed to the disease" - [WebMD]
  • Broccoli compound may inhibit lung cancer from tobacco smoke: Study - Nutra USA, 12/8/08 - "exposed experimental mice to carcinogenic compounds found in tobacco smoke called 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) plus benzo(a)pyrene (BaP) ... This resulted in an average of 21 tumours per mouse after 16 weeks. However, mice fed diets containing 1, 10, 30, 71, and 112 micromoles per gram of I3C were found to have reductions in the number of tumours by 15, 51, 53, 75, and 88 per cent, respectively" - See indole 3 carbinol at Amazon.com.
  • Broccoli May Help Smokers' Lungs - WebMD, 11/18/08 - "asked 948 lung cancer patients and 1,743 people without lung cancer about their smoking history and consumption of fruits, cruciferous vegetables, and other vegetables ... Among smokers -- and especially among former smokers -- higher intake of cruciferous vegetables was linked to lower risk of lung cancer"
  • Vitamin E may slash lung cancer risk: Study - Nutra USA, 10/31/08 - "The researchers calculated that the highest average intakes of alpha-tocopherol (more than 7.73 mg per day) were associated with a 53 per cent reduction in lung cancer risk, compared to the lowest average intakes (less than 4.13 mg per day) ... When the researchers accounted for the other tocopherols they observed no significant associations on lung cancer risk for beta-, gamma, and delta-tocopherol" - [Abstract] (see the abstract, I don't believe that last part is true on the gamma. - Ben
  • Red Wine May Lower Lung Cancer Risk - Science Daily, 10/7/08 - "there was on average a two percent lower lung cancer risk associated with each glass of red wine consumed per month ... Red wine is known to contain high levels of antioxidants. There is a compound called resveratrol that is very rich in red wine because it is derived from the grape skin. This compound has shown significant health benefits in preclinical studies" - [WebMD] - See resveratrol products at Amazon.com.
  • Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice - J Nutr. 2008 Jul;138(7):1360-4 - "soy phytochemicals slow the in vivo growth of NSCLC xenografts; the modulation of the Akt-signaling pathway observed in tumors of SSE-treated mice may have a role in the activity observed. Our research provides further support for the concept that consumption of phytoestrogens may be effective in delaying lung cancer progression"
  • Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk - Int J Cancer. 2008 Jun 10 - "When we entered the other tocopherols in our model, only the association with dietary alpha-tocopherol intake remained significant; i.e., increasing intake of dietary alpha-tocopherol accounted for 34-53% reductions in lung cancer risk"
  • Dietary flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's Health Study - Int J Cancer. 2008 May 19 - "After multivariable adjustment, lung cancer incidence was inversely associated with intakes of flavanones (HR = 0.68; 95% CI: 0.53-0.86, all results highest vs. lowest quintile) and proanthocyanidins (HR = 0.75; 95% CI: 0.57-0.97). Among current and past smokers, those with intakes in the highest quintile for flavanones (HR = 0.66; 95% CI: 0.50-0.86), and proanthocyanidins (HR = 0.66; 95% CI; 0.49-0.89) had significantly lower lung cancer incidence than those in the lowest quintile. Similar associations were not seen in never smokers. Isoflavone intake was inversely associated with overall cancer incidence (HR = 0.93, 95% CI: 0.86-1.00). This study provides further support for a beneficial effect of flavonoid intake on lung cancer risk, especially among current and past smokers" - See bioflavonoids at Amazon.com.
  • Lung Cancer Rarer in Sunny Countries? - WebMD, 12/18/07
  • Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 - People who ate quercetin-rich foods at least four times a week, on average, were 51% less likely to have lung cancer than those who ate none"
  • Lung cancer 'link to lack of sun' - BBC News, 12/18/07 - "Cancer results when cells start to divide in an uncontrolled fashion ... vitamin D stimulated the release of chemicals which, in combination with calcium, formed a glue-like substance which bind these cells tightly together, and put a brake on their division" - See vitamin D at Amazon.com.
  • New Lung Cancer Guidelines Oppose Certain Vitamins, Suggest Acupuncture - Science Daily, 9/10/07
  • Pomegranate Juice May Help Fight Lung Cancer - Science Daily, 4/27/07
  • Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows - Science Daily, 4/17/07
  • Milk Thistle May Slow Lung Cancer  - WebMD, 6/20/06 - "They found smaller lung tumors in the mice with silibinin in their diets, compared with those consuming no silibinin. They also had fewer large lung tumors"
  • Tomato Juice Keeps Emphysema From Developing In New Model; Lycopene Cited - Science Daily, 1/25/06 - "50% tomato juice drink "completely prevented" smoke-induced emphysema" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Tomato Juice Might Protect Lungs - HealthDay, 1/9/06 - "Tomato juice prevented emphysema in mice exposed to cigarette smoke ... They attributed the protective effect to lycopene" - See lycopene at Amazon.com.
  • Iron, calcium linked to lung cancer - Nutra USA, 12/5/05 - "The risk of lung cancer increased by 50 per cent for calcium intake greater than 1270 mg per day ... the increased lung cancer risk was the result of nonheme iron [iron from plant sources]… heme iron [from animal sources] was associated with decreased risk of lung cancer"
  • The Nude Mouse Tale: Omega-3 Fats Save The Life Of A Terminal Cancer Patient - Science Daily, 11/14/05 - "In 2000 he was told by his doctor he had only a few months to live ... But five years later, he is still alive, and has even gained a little weight ... It was a nutritional intervention, drastically increasing the patient’s intake of omega-3 fatty acids" - See Mega Twin EPA at Amazon.com.
  • Broccoli May Protect Some Against Lung Cancer - WebMD, 10/27/05 - "consumption of cruciferous vegetables was associated with a 33%-37% reduction in lung cancer risk among people with an inactive form of one of the two genes. Among those with an inactive form of both genes, the reduction in risk provided by eating cruciferous vegetables was doubled to more than 70%"
  • Veggies in Diet May Cut Lung Cancer Risk - WebMD, 9/27/05 - "the people who consumed the highest amount of phytoestrogens from food had nearly half the lung cancer risk as those with the lowest phytoestrogen intake from food" [Abstract]
  • Broccoli May Fight Lung Cancer - WebMD, 9/15/05
  • Compounds Found In Cruciferous Vegetables Block Lung Cancer Progression - Science Daily, 9/15/05 - "A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells"
  • Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 - "Statin users were 48% less likely to develop lung cancer than nonusers" - See Zocor at International Anti-aging Systems.
  • Lowering the Risk of Lung Cancer? - Dr. Weil, 4/28/05
  • Statins Lower Prostate Cancer Risk - WebMD, 4/18/05 - "looked at 450 men and women with early stage non-small-cell lung cancer ... The high-vitamin D group was more than twice as likely to be alive five years later"
  • Vitamin E In Plant Seeds Could Halt Prostate, Lung Cancer, Says Purdue Scientist - Science Daily, 12/30/04 - "gamma-tocopherol, which occurs naturally in walnuts, pecans, sesame seeds, and in corn and sesame oils, inhibits the proliferation of lab-cultured human prostate and lung cancer cells"  - See Jarrow FamilE (contains all eight members of the vitamin E family) at Amazon.com.
  • Vitamin E in Food May Fight Cancer - WebMD, 12/15/04 - "Most supplements provide a different form of the vitamin, alpha-tocopherol ... Gamma-tocopherol aced its lab tests. It inhibited the spread of prostate and lung cancer cells without hurting the healthy cells ... Mixing several forms of vitamin E -- including gamma-tocopherol -- was even better at blocking cancer's spread"  - See Jarrow FamilE (contains all eight members of the vitamin E family) at Amazon.com.
  • Gamma-tocopherol halts cancer cells in lab study - Nutra USA, 12/15/04 - "Gamma-tocopherol, found naturally in walnuts, sesame seeds and corn, was found to hold back the proliferation of lab-cultured human prostate and lung cancer cells, reports the team from Purdue University in the 13 December online edition of the Proceedings of the National Academy of Sciences ... This could indicate that the vitamin Could be used to target lung and prostate cancer cells without the damaging side effects of chemotherapy" - See Jarrow FamilE (contains all eight members of the vitamin E family) at Amazon.com.
  • Red Wine May Guard Against Lung Cancer - WebMD, 10/27/04
  • K-State Researcher Links Cigarette Smoke, Vitamin A Deficiency And Emphysema - Science Daily, 7/28/04 - "When the lung content of vitamin A was low, the score of emphysema was high ... So, the hypothesis is that smokers develop emphysema because of a vitamin A deficiency"
  • Beta-carotene Supplementation Appears to Increase Risk of Lung Cancer in Smokers - Doctor's Guide, 7/25/03
  • Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women's health study - Cancer Causes Control 2003 Feb;14(1):85-96 - "beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and total carotenoid intake were each associated with a significantly lower risk of lung cancer" - Note:  Beta-carotene is just one of over 600 carotenoids.  Some feel that taking mega-doses of just one can cause a deficiency of the others.
  • Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 - "Companies that manufacture selenium supplements will now be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers" - See selenium at Amazon.com.
  • NSAIDs May Reduce Lung Cancer Risk - Medscape, 3/18/03 - "using NSAIDs at least three times weekly for at least one year decreased risk of lung carcinoma by 32%, regardless of histology ... Aspirin had similar smoking-specific risk estimates to those for all NSAIDs, but the association of reduced lung cancer risk was found only in men and not in women ... Although it is unclear why the protective effect of NSAIDs was limited to smokers, the authors suggest that smoking might induce cyclooxygenase (COX)-2 expression. Cigarette tar extracts increase COX activity in rat lung cells, and COX-2 activity is higher in lung cancer tissue of smokers than in nonsmokers" - [WebMD] - See ibuprofen at Amazon.com and aspirin at Amazon.com.
  • Plant Compound May Prevent Lung Cancer - WebMD, 2/19/03 - "deguelin is found in several different types of plant species and is part of a class of compounds in the flavonoid family ... deguelin appeared to target the cancerous and precancerous cells, stopping their growth, while having minimal effects on the normal, healthy cells ... deguelin is highly specific and seems to work by zeroing in on a particular molecular pathway associated with lung cancer ... the findings are especially interesting because there have been so few agents that have shown potential to stop the progression of lung cancer"
  • Undoing Lung Damage? - Dr. Weil, 9/27/02
  • Positive Attitude Good for Lungs - Doctor's Guide, 5/21/02
  • Say Cheers: White Wine May Aid Lungs - Doctor's Guide, 5/21/02
  • Optimistic Outlook May Benefit The Lungs - Intelihealth, 5/21/02
  • Carrots, tomatoes keep lung cancer away - Life Extension Magazine, 9/01
  • B Vitamins Cut Cancer Risks - Doctor's Guide, 7/01
  • Canceling Cancer: New Cancer Prevention Strategies on the Horizon - WebMD, 3/26/01 - "an enzyme called telomerase is important for the growth of most cancer cells but not so crucial for the growth of normal cells ... By giving a compound similar to vitamin A to a group of heavy smokers, they were able to reduce the amount of telomerase activity. Their findings indicate that this compound might be useful in the future to prevent lung cancer in former smokers"
  • Breathe Easier With Fruits and Veggies, Study Finds They May Lower Lung Cancer Risk - WebMD, 10/9/00
  • 13-Cis Retinoic Acid With Or Without Alpha Tocopherol May Protect Against Lung Cancer Precursor - Doctor's Guide, 9/13/00
  • One More Reason To Eat Your Broccoli, Chemical Compounds Found to Prevent Lung Cancer - WebMD, 8/25/00
  • Nutritional Soup for Cancer - Nutrition Science News, 8/00
  • Study Suggests Certain Vitamins Protect Against Deadly Lung Disease - WebMD, 6/5/00 - "The study investigates an association between lung function and a diet high in vitamin C, vitamin E, carotene, and selenium. All are antioxidants, substances that can counteract oxidants -- harmful natural and unnatural chemicals in our environment -- and protect cells in the body"
  • Cancer's Sweet Tooth - Nutrition Science News, 4/00
  • Vitamin E: Weighing the Tocopherols - Nutrition Science News, 1/99

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