Home > Anti-aging Research > Celebrex™.

COX-2 Inhibitors (Celebrex™ (celecoxib)/Vioxx™ (rofecoxib)/Mobic (meloxicam), etc.)

Specific Recommendations:

• See online prescriptions

Popular Supplements:

• curcumin / omega-3 fatty acids / resveratrol / quercetin

Alternative News:

• Chondroitin/Glucosamine Reduced Pain in Knee Arthritis in RCT - Medscape, 1/30/15 - "a combination glucosamine/chondroitin sulfate product produced a 50.1% decrease in Western Ontario and McMaster OA index (WOMAC) pain, which is comparable to the 50.2% decrease seen in patients randomly assigned to receive celecoxib ... Patients received either chondroitin sulfate 400 mg plus glucosamine hydrochloride 500 mg (CS+GH; Droglican, Bioibérica SA) three times a day or celecoxib 200 mg every day for 6 months" - See glucosamine chondroitin formulas at Amazon.com.
• Why omega-3 oils help at the cellular level - Science Daily, 5/15/12 - "The scientists fed mouse macrophages -- a kind of white blood cell -- three different kinds of fatty acid: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA). EPA and DHA are major polyunsaturated omega-3 fatty acids, essential to a broad range of cellular and bodily functions, and the primary ingredient in commercial fish oil dietary supplements. AA is a polyunsaturated omega-6 fatty acid prevalent in the human diet ... They discovered that omega-3 fatty acids inhibit an enzyme called cyclooxygenase (COX), which produces the prostaglandin hormones that spark inflammation. The action is similar to what happens when one takes an aspirin, which disrupts the COX-2 signaling pathway, thus reducing inflammation and pain ... On the other hand ... omega-3 oils do not inhibit another group of enzymes called lipoxygenases (LOX), which are also produced by stimulated macrophages. One type of generated LOX enzyme in turn produces fat-signaling molecules called leukotrienes, which are pro-inflammatory. But Norris noted that LOX enzymes may also generate anti-inflammatory compounds called resolvins from EPA and DHA" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Pomegranate extract may stop inflammation, says Bugs - Nutra USA, 6/13/08 - "COX-1 and COX-2 activity was significantly reduced in the pomegranate-fed animals, compared to control, particularly for COX-2. Indeed, COX-1 activity was reduced by about seven per cent following ingestion of the extract, while COX-2 activity decreased by about 26 per cent" - [Science Daily] - See pomegranate at Amazon.com.
• 3 Herbal Medicines May Ease Back Pain - WebMD, 4/18/06 - "A 60-milligram daily dose of devil's claw also appeared to cut back pain as much as a 12.5-milligram daily dose of Vioxx, a painkiller no longer on the market due to a rise in the risk of cardiovascular events -- such as heart attackheart attack and strokestroke -- in some patients"
• Pycnogenol reduces osteoarthritis pain, study - Nutra USA, 2/6/06 - "300 mg pine bark extract supplements ... Thirty minutes after taking the supplement, the mean inhibition of COX-1 and COX-2 was 22.5 and 15 per cent"
• How CLA fights inflammatory disease - Nutra USA, 10/19/05 - "one of the CLA isomers is a natural regulator of the COX-2 protein"
• Aspirin Might Prevent Vioxx Cardiac Damage - Science Daily, 9/14/05
• Are Anti-Inflammatory Herbs Safe for the Heart? - Dr. Weil, 5/20/05
• Alternatives for Arthritis Pain? - Dr. Weil, 11/11/04
• S-Adenosyl Methionine May Be As Efficacious As Celecoxib in Management of Knee Osteoarthritis, But Onset of Action Is Slower - Doctor's Guide, 5/4/04 - "During the first month of phase 1, celecoxib was significantly more effective in reducing pain than was SAMe (P= .024); however, by the second month of phase 1, patients in both groups had significant pain improvement from baseline (PS</i>] < .01), and no significant difference in pain was observed between groups" - See iHerb or Vitacost SAMe products.
• “Herbal Aspirin” Effective for Low Back Pain - New Hope Natural Media, 9/19/02 - "randomly assigned to daily treatment with four capsules of a standardized extract of willow bark (containing 240 mg of salicin per day) or one 12.5-mg tablet of the anti-inflammatory drug rofecoxib (Vioxx®) for four weeks. In all measures of pain relief, willow bark treatment was found to be as effective as rofecoxib" - See iHerb and Vitacost willow bark products.
• A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine, 7/02 - See curcumin at iHerb or Vitacost.
• Willow Bark Cheap Alternative To Pain Killers For Low Back Pain - Intelihealth, 1/31/02 - "Noting that willow bark is roughly 40% less expensive than rofecoxib [Vioxx], the researchers conclude that willow bark and rofecoxib are equally safe and effective in the treatment of low back pain, but that willow bark extract "has the current advantage of being cheaper than rofecoxib.""
• COX-2 inhibitors and cancer treatment - Life Extension Magazine, 10/00
• Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science News, 8/00
• Using Arthritis Drugs To Treat Cancer - Life Extension Magazine, 3/00

CME:

News & Research:

• Celecoxib may prevent lung cancer in former smokers - Science Daily, 7/6/11
• Anti-inflammatory drug may fight breast cancer - Science Daily, 5/5/11
• Widely used arthritis pill protects against skin cancer, study suggests - Science Daily, 12/2/10 - "Celecoxib, a prescription-strength nonsteroidal anti-inflammatory drug (NSAID), reduced basal cell carcinomas by 68 percent and squamous cell carcinomas by 58 percent in patients at high risk for skin cancer. The decrease in the incidence of these cancers is much greater than that achieved through the use of sunscreen, which provides only moderate protection against squamous cell and basal cell carcinomas"
• Celebrex inhibited the burden of skin cancer in high-risk patients - Science Daily, 1/5/10
• Celebrex May Slow, Prevent Skin Cancers - WebMD, 1/5/10 - "There is mounting evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) may help prevent or slow the growth of non- melanoma skin cancers ... the Cox-2 arthritis drug Celebrex was found to reduce the growth of basal cell skin cancers by 50% in some patients with a rare genetic condition that makes them highly susceptible to the tumors"
• Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure - Arch Intern Med. 2009 Jan 26;169(2):141-9 - "The hazard ratio (95% confidence interval) for death was 1.70 (1.58-1.82), 1.75 (1.63-1.88), 1.31 (1.25-1.37), 2.08 (1.95-2.21), 1.22 (1.07-1.39), and 1.28 (1.21-1.35) for rofecoxib, celecoxib, ibuprofen, diclofenac, naproxen, and other NSAIDs, respectively. Furthermore, there was a dose-dependent increase in risk of death and increased risk of hospitalization because of myocardial infarction and HF. Propensity-based risk-stratified analysis and case-crossover models yielded similar results"
• Prostate Cancer Can Be Halted With Anti-inflammatory And Statin Used In Tandem, Study Suggests - Science Daily, 4/14/08 - "A combination of low doses of Lipitor and Celebrex had a more potent inhibiting effect on the formation of later stage tumors than a higher dose of either agent alone ... The results from our study indicate that a combination of Lipitor and Celebrex may be an effective strategy for the prevention of prostate cancer progression from the first to the second stage"
• Popular Arthritis Drug May Disrupt Heart Rhythm, New Research Finds - Science Daily, 1/24/08 - "Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart"
• Vioxx Side-effects: Possible Explanation - Science Daily, 8/27/07
• COX Inhibitors May Weaken Protective Qualities Of Estrogen Hormone Therapy - Science Daily, 5/23/07
• Green Tea And COX-2 Inhibitors Combine To Slow Growth Of Prostate Cancer - Science Daily, 3/1/07 - "In mice that were not treated with either substance, the tumor volume averaged 1,300 cubic millimeters, whereas mice given either the tea or celecoxib had tumors averaging 835 cubic millimeters and 650 cubic millimeters, respectively. Tumors taken from mice given both agents, however, measured on average a volume of 350 cubic millimeters"
• Mixed reviews for Vioxx successor - MSNBC, 11/13/06
• Study Finds That Vioxx Reduces The Risk Of Colorectal Polyps - Science Daily, 8/31/06
• New Study Re-evaluates Cardiovascular Risks of Anti-inflammatory Drugs - Doctor's Guide, 6/2/06
• Analysis Clarifies Cox-2 Heart Risk - WebMD, 6/1/06
• Celebrex May Up Blood Pressure - WebMD, 5/19/06
• Celebrex may fight cancer, but with risks - MSNBC, 4/3/06
• Regular Use Of Selective COX-2 Inhibitors Decreases Risk Of Breast Cancer - Science Daily, 1/30/06 - "a daily dose of 200 mg celecoxib reduced the risk of breast cancer by 83% and a daily dose of 25 mg rofecoxib reduced the risk of breast cancer by 64%. Regular use of non-selective COX-2 inhibitors - aspirin (325 mg), ibuprofen (200mg) and naproxen (250 mg) - also significantly reduced the risk of breast cancer, but less so than regular intake of selective COX-2 inhibitors"
• 'Vioxx Like' Drugs May Still Be Best Option for Arthritis, Write Scientists - Doctor's Guide, 1/18/06
• No Evidence that COX-2 inhibitors Provide Greater Stomach Protection - Doctor's Guide, 12/2/05
• New Pain Pills: Not Easier to Stomach? - WebMD, 12/1/05 - "patients taking Cox-2 inhibitors had no fewer stomach bleeds or ulcers than those taking traditional NSAIDs"
• Study Casts New Doubt On Pain Killer Safety - CBS 2 Chicago, 4/18/05
• New FDA Labeling for Pfizer's Celebrex, Pfizer Agrees to Suspend Sales of Bextra - Doctor's Guide, 4/7/05
• Celebrex Provides A Two Pronged Attack Against Prostate Cancer - Science Daily, 3/18/05 - "Celebrex, not only targets COX-2, but also reduces levels of a key protein, cyclin D1, that's critical for cell replication"
• Study: Low-Dose Celebrex Poses No Heart Risk - WebMD, 2/17/05
• COX-2 Inhibitors Associated with Blood Pressure Elevation - Doctor's Guide, 2/14/05
• Newer Pain Relievers No Safer for Stomach - WebMD, 1/25/05
• Celecoxib Shows Surprising Activity Against Estrogen Receptors - Science Daily, 12/23/04
• What Should Celebrex And Bextra Patients Do? University Of Michigan Expert Says There Are Still Plenty Of Options - Science Daily, 12/20/04
• Arthritis Drug May Prevent Breast Cancer - WebMD, 12/10/04
• Celebrex may be safer than Vioxx, study finds - MSNBC, 12/6/04
• Drug May Hinder Recovery From Heart Attacks - Science Daily, 11/18/04
• Valdecoxib Linked to Cardiovascular Complications - Doctor's Guide, 11/12/04
• New Worries Tarnishing Arthritis Drugs - Intelihealth, 11/11/04
• Bextra Ups Heart Attack, Stroke Risk - WebMD, 11/10/04
• Arthritis Drug May Shrink Breast Cancers - WebMD, 11/5/04
• Celebrex May Be Safe for Ulcerative Colitis - WebMD, 11/2/04
• Pfizer Warns of Skin, Heart Risks From Bextra - WebMD, 10/15/04
• Celecoxib (Celebrex) May Foil Recurrent Prostate Cancer - Doctor's Guide, 10/13/04
• Vioxx Unsafe: So What About Similar Drugs? - WebMD, 10/7/04
• Report: Vioxx linked to thousands of deaths - MSNBC, 10/7/04 - "Merck & Co.’s arthritis drug Vioxx may have led to more than 27,000 heart attacks and sudden cardiac deaths before it was pulled from the market last week"
• Vioxx Fall No Surprise to Heart Docs - WebMD, 10/1/04
• Merck Announces Voluntary Worldwide Withdrawal of Vioxx (Rofecoxib) - Doctor's Guide, 9/30/04
• FDA Issues Public Health Advisory on Vioxx as its Manufacturer Voluntarily Recalls the Product - Doctor's Guide, 9/30/04
• Vioxx Questions and Answers - WebMD, 9/30/04
• Trial Confirms Overall Benefits of Prexige (Lumiracoxib) Over NSAIDs in Combined Gastrointestinal and Cardiovascular Safety - Doctor's Guide, 9/29/04
• COX-2 Valdecoxib Appears To Produce Only Half The Side-Effects But Shows Double The Compliance Of Non Steroidal Anti-Inflammatory Drugs - Doctor's Guide, 9/8/04
• FDA Approves Vioxx (Rofecoxib) for Once-Daily Treatment of Juvenile Rheumatoid Arthritis - Doctor's Guide, 9/8/04
• More Evidence: Vioxx Increases Heart Risks - WebMD, 8/26/04
• Prexige (Lumiracoxib) Appears To Significantly Reduce Gastrointestinal Events Without Compromising Cardiovascular Safety Compared To Nsaids - Doctor's Guide, 8/26/04
• Prexige Significantly Reduces Gastrointestinal Events Without Compromising Cardiovascular Safety Compared To NSAIDs - Doctor's Guide, 8/20/04
• Lumiracoxib May Be Useful for Osteoarthritis Without Worsening Cardiac Risk - Medscape, 8/20/04
• New Drug [Prexige] Treats Arthritis, Easy on Stomach - WebMD, 8/19/04
• Painkiller Vioxx Often Taken at Too High Dose - WebMD, 7/14/04
• Vanderbilt Research Shows High Doses Of Popular Pain Reliever Prescribed Despite Heart Risk - Science Daily, 7/13/04
• Popular Painkiller May Slow Prostate Cancer - WebMD, 6/11/04
• Rofecoxib but not Celecoxib Associated With Increased Risk of Oedema and Blood Pressure Increase - Doctor's Guide, 6/10/04
• Arthritis Drug Linked to Heart Failure - WebMD, 5/27/04
• Naproxen Associated With Longer Life Expectancy Than Rofecoxib In Patients With Rheumatoid Arthritis - Doctor's Guide, 5/14/04
• Rofecoxib Associated With Increased Acute Myocardial Infarction Risk in Elderly Patients - Doctor's Guide, 5/6/04
• A Comparison of the Efficacy of Placebo, Acetaminophen, and Celecoxib in Patients With Osteoarthritis of the Knee or Hip - Doctor's Guide, 4/27/04
• Valdecoxib Relieves Dental Pain With Few Adverse Effects - Doctor's Guide, 4/20/04
• Once Daily Lumiracoxib as Effective as Celecoxib for Knee Osteoarthritis - Doctor's Guide, 4/2/04
• Vioxx, Blood Pressure Medications Don't Mix - WebMD, 3/11/04 - "taking both Vioxx and high blood pressure medications doubles the risk of a heart attack"
• Rofecoxib May Increase Cardiovascular Events Risk in Arthritis Patients on Antihypertensive Medications - Doctor's Guide, 3/11/04
• Day or Night Celecoxib Equally Relieve Osteoarthritic Pain - Doctor's Guide, 2/19/04
• Celecoxib and Diclofenac Differ In Their 24-Hour Effects on Blood Pressure - Doctor's Guide, 2/17/04
• Rofecoxib Not Associated with Increased Risk of Cardiovascular Events or Death - Doctor's Guide, 10/30/03
• Licofelone Offers Equal Efficacy With Better Tolerability Than Celecoxib for Knee Osteoarthritis - Doctor's Guide, 10/28/03
• Etoricoxib Once Daily May be as Effective as Diclofenac for Treatment of Rheumatoid Arthritis - Doctor's Guide, 10/28/03
• 12.5 mg/day Rofecoxib First Choice for Knee Osteoarthritis - Doctor's Guide, 10/28/03
• Valdecoxib and Rofecoxib Comparable at Two Weeks, Valdecoxib More Effective in First Six Hours, for Knee Osteoarthritis With Flare - Doctor's Guide, 10/28/03
• Celecoxib Associated with Fewer Gastrointestinal Claims - Doctor's Guide, 10/27/03
• Rofecoxib is Effective Treatment Option for Osteoarthritis Patients that Do Not Respond to Celecoxib - Doctor's Guide, 10/16/03
• Rofecoxib as Effective as Naproxen, but Has Better Gastrointestinal Tolerability - Doctor's Guide, 10/15/03
• Celecoxib Inhibits Metoprolol Metabolism, But Rofecoxib Does Not - Doctor's Guide, 9/11/03
• Incidence Of Cardiovascular Adverse Events Similar Among Patients Treated With Celecoxib, Nonsteroidal Anti-Inflammatories, Or Placebo - Doctor's Guide, 9/10/03 - "For primary cardiovascular events, the relative risks (RRs) comparing celecoxib with NSAIDs were 1.06 (95% CI 0.70 to 1.61, p = 0.79) for all patients, and 0.86 (95% CI 0.48 to 1.56, p = 0.62) for patients not treated with aspirin. The RR comparing celecoxib and placebo was 0.85"
• Fewer Confirmed Upper Gastrointestinal Events with Etoricoxib Treatment than Ibuprofen - Doctor's Guide, 8/29/03
• Rofecoxib Effective, Tolerable Treatment of Choice for Osteoarthritis - Doctor's Guide, 7/23/03
• Low Incidence Of Thromboembolic Events Associated With Rofecoxib And Meloxicam During Nine Months After Prescription - Doctor's Guide, 7/16/03
• First Report of Celecoxib-Associated Oesophagitis - Doctor's Guide, 7/11/03
• Valdecoxib Safe, Effective New Option for Rheumatoid Arthritis Treatment - Doctor's Guide, 7/10/03
• Adverse Gastrointestinal Events are Fewer for Celecoxib than Meloxicam - Doctor's Guide, 7/7/03
• Rofecoxib Effective in Treating Certain Eye Conditions - Doctor's Guide, 6/11/03
• Neither Rofecoxib Nor Naproxen Slows Cognitive Decline Of Mild To Moderate Alzheimer Disease - Doctor's Guide, 6/6/03
• Arthritis Pain Therapy Using Coxibs is More Expensive Than Using NSAIDs Despite Gastrointestinal Benefits - Doctor's Guide, 6/5/03
• Endoscopically Detectable Gastroduodenal Ulcers Less Common in Rheumatoid Arthritis Patients Taking Rofecoxib Compared to Naproxen - Doctor's Guide, 5/28/03
• COX-2 specific Inhibitor Causes Fewer Small Bowel Lesions than Alternative Arthritis Treatment - Doctor's Guide, 5/23/03
• Valdecoxib Better Tolerated than Nonsteroidal Anti-inflammatory Drugs for Arthritis - Doctor's Guide, 5/22/03
• Celecoxib Reduces Use of GI-Related Health Resources Compared to NSAIDs in Elderly - Doctor's Guide, 5/22/03
• Rofecoxib Increases Weight, Blood Pressure in Rheumatoid-Arthritis Patients - Doctor's Guide, 5/20/03
• Rofecoxib Shows Sustained Benefit in Osteoarthritis After Two Years - Doctor's Guide, 5/16/03
• Little Risk of Hypertension with COX-2 Blockers - Doctor's Guide, 5/16/03
• Rofecoxib Increases Systolic Blood Pressure in Hypertensives with Osteoarthritis and Type 2 Diabetes - Doctor's Guide, 5/16/03
• Greater Reduction In Incidence Rates Of Selected Gastrointestinal Events With Rofecoxib Compared With Meloxicam - Doctor's Guide, 5/15/03
• Investigational Arcoxia (Etoricoxib) Relieves Acute Gouty Arthritis Pain As Well As Indomethacin - Doctor's Guide, 3/20/03
• Vioxx (Rofecoxib) Provides Acute Pain Relief as Effective as a Commonly Prescribed Narcotic - Doctor's Guide, 3/20/03
• Celecoxib-Induced Upper Gastrointestinal Hemorrhage and Ulceration - Medscape, 3/19/03
• Rofecoxib Appears to Have Earlier Onset of Osteoarthritis Pain Relief - Doctor's Guide, 2/24/03 - "Rofecoxib 25 mg achieved a faster onset of efficacy for osteoarthritis (OA) pain and stiffness than celecoxib 200 mg, and both COX-2 inhibitors had quicker onset than acetaminophen 4000 mg ... Median time for good or excellent PGART response was day 3 for rofecoxib 25 mg, day 4 for rofecoxib 12.5 mg, day 5 for celecoxib mg and day 6 for acetaminophen"
• New Arthritis Drugs May Help Heart - WebMD, 1/13/03
• Study Questions Celebrex Use For Ulcers - Intelihealth, 12/26/02
• Study Finds Celebrex No Safer Than NSAIDs in Preventing Recurring Bleeding - WebMD, 12/23/02
• Celecoxib May Improve Breast Cancer Outcomes - Medscape, 12/16/02
• Rofecoxib May Not Negatively Affect Blood Pressure in Younger, Healthier Patients - Doctor's Guide, 12/16/02
• Hypertension Increases May Be Lower with Celecoxib than with Rofecoxib - Doctor's Guide, 12/12/02 - "Elderly patients with hypertension who take non-steroidal anti-inflammatory drugs (NSAID) for arthritis or other conditions may see fewer adverse effects on blood pressure with celecoxib than with rofecoxib"
• Rofecoxib Has Good Cardiovascular Safety Profile in Older Patients with Alzheimer's or Cognitive Impairment - Doctor's Guide, 11/20/02
• Arthritis Drug [Bextra] May Cause Severe Reaction - WebMD, 11/15/02
• One-Year Results from an Active Comparator-Controlled Trial of Rofecoxib in Patients with Rheumatoid Arthritis - Doctor's Guide, 10/30/02
• Valdecoxib Safety Shown Equal to Non-Steroidal Anti-Inflammatory Drugs in Arthritis Patients - Doctor's Guide, 10/29/02
• Valdecoxib Effective With or Without Concomitant Medications, Including DMARDs - Doctor's Guide, 10/29/02
• Functional Improvement in Chronic Low Back Pain Seen With Etoricoxib Study - Doctor's Guide, 10/29/02
• Analysis of Upper Gastrointestinal Events in Clinical Trials with Rofecoxib Versus Non-Steroidal Anti-Inflammatory Drugs - Doctor's Guide, 10/28/02
• Further Analysis Shows Risk of Cardiovascular Events Not Significantly Increased with Rofecoxib - Doctor's Guide, 10/28/02
• Preoperative Ketorolac More Effective Post-Operatively, Vioxx (Rofecoxib) More Effective After Patient Discharge - Doctor's Guide, 10/15/02
• Celebrex Stops Preterm Labor - WebMD, 9/30/02 - "Celebrex was found to work just as well as the most common preterm labor drug, but was much safer for mother and baby"
• Arthritis Drug [Celebrex] Slows ALS in Mice - WebMD, 9/25/02
• Celebrex May Be Safe For Preterm Labor, Preliminary Study Finds - Doctor's Guide, 9/24/02
• Pharmacia and Pfizer Announce FDA Approval For New 400 mg Strength Celebrex® Capsule for Treatment of Familial Adenomatous Polyposis - Doctor's Guide, 9/9/02
• Health Canada Approves Changes to Vioxx (Rofecoxib) Label to Reflect GI Safety Data from Landmark Study - Doctor's Guide, 8/21/02
• Etoricoxib Superior to Oxycodone/Acetaminophen for Acute Pain - Doctor's Guide, 8/21/02
• Celecoxib Safe in Aspirin-Exacerbated Respiratory Disease - Medscape, 8/6/02
• COX-2 Specific Inhibitor Bextra (Valdecoxib) Effective And Well-Tolerated Treatment For Painful Menstrual Cramping - Doctor's Guide, 8/1/02
• Valdecoxib Receives Positive Opinion In Europe From Committee For Proprietary Medicinal Products - Doctor's Guide, 7/26/02
• Dog's tale of survival opens door in cancer research - USA Today, 7/24/02 - "When researchers heard that Navy was cancer-free after receiving a cocktail of drugs already approved by the Food and Drug Administration — Celebrex, tamoxifen (sold as Nolvadex) and doxycycline — the treatment became known as the Navy Protocol ... Navy's treatment, though experimental, cost $2,000"
• Celecoxib Helpful Add-On Therapy in Schizophrenia - Doctor's Guide, 6/28/02
• Blood Pressure Changes with Non-Steroidal Anti-Inflammatory Drugs Measured - Doctor's Guide, 6/26/02
• Etoricoxib an Effective Alternative to Indometacin for Gouty Arthritis - Doctor's Guide, 6/24/02
• Long-Term Treatment of Osteoarthritis with Vioxx (Rofecoxib) and Diclofenac Continues to be Effective - Doctor's Guide, 6/19/02
• Adverse Cardiovascular Events with Rofecoxib Similar to Placebo in Elderly Population - Doctor's Guide, 6/19/02
• Vioxx (Rofecoxib) Safer than Naproxen for Lower Gastrointestinal Tract in Older Rheumatoid Arthritis Patients - Doctor's Guide, 6/19/02
• New COX-2 Inhibitor Etoricoxib Looks Promising for Back Pain, Rheumatoid Arthritis and Acute Gouty Arthritis - Doctor's Guide, 6/17/02
• Celecoxib Treatment Results in Fewer Adverse Events and Therefore Costs Less than Rofecoxib and Traditional NSAIDs - Doctor's Guide, 6/17/02
• Edema Rates May be Higher with Rofecoxib than other Common NSAIDs - Doctor's Guide, 6/17/02
• Channeling and Reporting Bias Evident in Observational Studies of GI Toxicity with Meloxicam and COX-2 Inhibitors - Doctor's Guide, 6/17/02
• Physicians Favor Celebrex (Celecoxib) for Patients with High Cardiovascular Risk - Doctor's Guide, 6/17/02
• Patients with Rheumatic Diseases Stick to COX-2 Inhibitor Therapy More than Traditional NSAIDs - Doctor's Guide, 6/17/02
• Rofecoxib Linked to Hypertension in Patients with Rheumatoid Arthritis and Osteoarthritis - Doctor's Guide, 6/17/02
• Valdecoxib Beats out Ibuprofen and Diclofenac with Respect to Dyspepsia Symptoms in Osteoarthritis Patients - Doctor's Guide, 6/17/02
• Celebrex (Celecoxib) a More Satisfactory Treatment than NSAIDS, According to Osteoarthritis Patients - Doctor's Guide, 6/17/02
• Celecoxib Found as Effective as Diclofenac for Pain from Ankle Sprain - Doctor's Guide, 6/14/02
• FDA Approves New Celebrex (Celecoxib) Prescribing Information; New Data Included From CLASS Study - Doctor's Guide, 6/7/02
• Highly Sensitive COX-2 Inhibitor, Etoricoxib, Effective In Treating Rheumatoid Arthritis Pain - Doctor's Guide, 6/7/02
• Study Finds Two Expensive Pain Relievers Often Prescribed When Cheaper Medicines Would Suffice - Intelihealth, 6/4/02 - "The drugs - Vioxx and Celebrex - are heralded for their ability to relieve pain without the gastrointestinal upsets of older, cheaper drugs like ibuprofen or naproxen. However, the study found that 76 percent of prescriptions written are for patients who show no risk of such side effects"
• Experts Question Safety of Arthritis Drug - WebMD, 5/30/02 - "The published report of the Celebrex Long Term Arthritis Safety Study (CLASS), sponsored by the drug's manufacturer, concluded that people taking Celebrex for six months had lower rates of stomach and intestinal ulcers than those taking two older arthritis drugs - diclofenac and ibuprofen. But the study actually lasted for a year, and the summary ignored later data showing no safety advantage for the newer drug"
• Painkillers May Delay Bone Healing - Intelihealth, 5/28/02
• Celecoxib Plus Standard Chemotherapy Results in High Response Rate in Non-Small Cell Lung Cancer - Doctor's Guide, 5/22/02
• Popular Arthritis Drug [Celebrex] KO's Lung Cancer - WebMD, 5/21/02 - "In a small study of 16 patients with early cancer than had not spread beyond the lungs, patients who took Celebrex along with chemotherapy benefited from the treatment, and the cancer virtually disappeared in five patients ... In eight other patients, tumors shrank, and four more patients had stable disease ... The expected complete clinical response rate -- meaning that tumors are no longer visible by X-ray -- with the chemotherapy alone "is just 1%, so these results were very encouraging.""
• Vioxx Safer on Lower Digestive Tract, Too - WebMD, 5/21/02
• Patients With Juvenile Rheumatoid Arthritis Respond Well To Meloxicam - Doctor's Guide, 5/15/02
• Fewer Gastrointestinal Events Seen With Cox-2 Inhibitors - Doctor's Guide, 5/8/02
• New COX-2 Specific Inhibitor Valdecoxib Compared to Oxycodone/Acetaminophen for Pain Relief After Dental Surgery - Doctor's Guide, 5/8/02
• Drug dilemma confronts users of painkillers - USA Today, 4/14/02 - "Arthritis patients looking for pain relief may start feeling as if they have to choose between two evils: a bleeding ulcer from some drugs, maybe a higher risk of heart attack from another"
• FDA Approves Label Changes for Vioxx (Rofecoxib), Endorses New Indication for Adult Rheumatoid Arthritis - Doctor's Guide, 4/11/02
• Bextra (Valdecoxib) Now Widely Available in U.S. for Arthritis Pain/Inflammation and Menstrual Cramping - Doctor's Guide, 4/10/02
• Pain Drug Vioxx Linked to Meningitis - WebMD, 3/25/02
• Bextra (Valdecoxib) Shows Promise in Relieving Post-Surgical Dental Pain - Doctor's Guide, 3/25/02
• Dysmenorrhea Improves with Etoricoxib - Doctor's Guide, 3/18/02
• Tramadol/Acetaminophen Helpful as Add-On Therapy for Arthritis Patients Taking COX-2 NSAIDS - Doctor's Guide, 3/18/02
• Vioxx (Rofecoxib) Relieves Acute Pain from Dental Surgery Better than Oxycodone/Acetaminophen Combination - Doctor's Guide, 3/4/02
• Vioxx (Rofecoxib) Shows Osteoarthritis Pain Relief Superior to Celebrex (Celecoxib) or Acetaminophen - Doctor's Guide, 1/8/02
• Rofecoxib Offers Advantages in Treatment of Knee Osteoarthritis - Doctor's Guide, 1/3/02
• FDA Approves Bextra (Valdecoxib) for Pain/Inflammation of Arthritis and Menstrual Cramps - Doctor's Guide, 11/19/01
• Rheumatoid Arthritis Drug Rofecoxib May Raise Blood Pressure Significantly - Doctor's Guide, 11/16/01
• Celebrex (Celecoxib) Reduces Gastrointestinal-Related Health Care Resource Use Compared to Diclofenac and Naproxen - Doctor's Guide, 11/14/01
• Celebrex (Celecoxib) Provides Similar Efficacy and Improved Safety Compared to Diclofenac and Naproxen - Doctor's Guide, 11/14/01
• Celebrex (Celecoxib) Brings No Increased Risk of Adverse Cardiovascular Events Compared to Ibuprofen, Diclofenac, Naproxen - Doctor's Guide, 11/13/01
• Celebrex (Celecoxib) as Effective/Safer Than Two Traditional Non-steroidal Anti-inflammatories in Osteoarthritis - Doctor's Guide, 11/13/01
• Celebrex (Celecoxib) 200 mg Comparable To Vioxx (Rofecoxib) 25 mg in Osteoarthritis Study - Doctor's Guide, 11/13/01
• FDA Approves Celebrex (Celecoxib) for Acute Pain Relief - Doctor's Guide, 10/22/01
• Pharmacia/Pfizer: Celebrex Safety Profile Well-Established - Doctor's Guide, 8/23/01
• Merck Stands Behind Cardiovascular Safety Profile of Vioxx (Rofecoxib) - Doctor's Guide, 8/22/01
• Pharmacia and Pfizer Address Article in August 22/29 Issue of The Journal of the American Medical Association - Doctor's Guide, 8/22/01
• Popular Anti-Inflammatory Drugs May Increase Risk of Cardiovascular Events - Doctor's Guide, 8/22/01
• Report Suggests Heart Link With Celebrex, Vioxx, But Critics Say More Research Needed - Intelihealth, 8/21/01 - "The popular and heavily promoted new arthritis drugs Vioxx and Celebrex have been linked by researchers to a small but troubling increase in the risk of heart attacks and strokes"
• Safety of Arthritis Drugs in Question - WebMD, 7/10/01 - "the cardiovascular safety of Vioxx and Celebrex, another COX-2 inhibitor, has been questioned; and a report published in a recent issue of The Lancet suggests this group of drugs also can harm the kidneys"
• Arthritis Drug [Vioxx] May Help Migraines - WebMD, 6/29/01
• Debate Separates Hype From Evidence In Cox-2 Inhibitor Competition - Doctor's Guide, 6/17/01
• Mobicox (Meloxicam) Shows High Rate of Patient Satisfaction In Osteoarthritis - Doctor's Guide, 6/15/01
• Rofecoxib Demonstrates Fewer Gastrointestinal Complications Than Naproxen Over One Year - Doctor's Guide, 6/15/01
• Celecoxib 200 mg and Rofecoxib 25 mg Have Comparable Efficacy in Osteoarthritis - Doctor's Guide, 6/14/01
• Celecoxib as Effective, Safer Than Diclofenac and Naproxen for Osteoarthritis - Doctor's Guide, 6/14/01
• Celecoxib Provides Better Pain Control Than Diclofenac In Osteoarthritis And Rheumatoid Arthritis Patients - Doctor's Guide, 6/14/01
• Fewer Treatment-Limiting Gastrointestinal Side Effects With Vioxx (Rofecoxib) Than Naproxen for Osteoarthritis - Doctor's Guide, 6/14/01
• COX-2 Inhibitor, Celecoxib, as Effective and Safe as Naproxen and Diclofenac - Doctor's Guide, 6/14/01
• Pivotal Studies Show Differences Between COX-2 Inhibitors In Renal And Hypertensive Effects - Doctor's Guide, 6/14/01
• Further Evidence Supports GI Safety, Upper GI Tolerability Of Celecoxib Compared With NSAIDs - Doctor's Guide, 5/25/01
• Favourable Cardiovascular Safety Profile Confirmed for Vioxx (Rofecoxib) - Doctor's Guide, 5/23/01
• Celebrex (Celecoxib), Vioxx (Rofecoxib) Produce Different Blood Pressure/Edema Effects in Osteoarthritis Patients - Doctor's Guide, 5/11/01 - "more patients taking Vioxx® (rofecoxib) experienced statistically significant and clinically important increases in systolic blood pressure (SBP) and edema versus patients taking Celebrex® (celecoxib)."
• Study Focuses On Arthritis Drugs - Intelihealth, 5/12/01 - "Patients taking the anti-arthritis drug Vioxx are more likely to suffer high-blood pressure and swelling than patients taking Celebrex"
• Once Daily Vioxx (Rofecoxib) Significantly Reduces Chronic Low Back Pain - Doctor's Guide, 4/23/01
• Parecoxib Appears As Effective As Ketorolac, Morphine In Reducing Knee Surgery Pain - Doctor's Guide, 4/22/01 - "40 mg of intravenous parecoxib provides equivalent pain relief for up to 24 hours as did ketorolac, the only available intravenous (IV) non-steroidal anti-inflammatory drug ... In addition, parecoxib, an investigational cyclooxygenase (COX-2) inhibitor, was statistically significantly more effective in controlling pain than 4 mg of morphine, 20 mg of parecoxib and placebo"
• Rofecoxib Better Than Combination Acetaminophen/Codeine For Acute Pain Control - Doctor's Guide, 4/22/01 - "Rofecoxib [Vioxx] was superior to the narcotic combination in total pain relief over six hours, in peak pain relief, in the patient's own assessment of pain relief and in the time required to take rescue medication"
• Another Link Between Cox-2 Expression and Breast Cancer - Doctor's Guide, 3/29/01 - "This finding leaves the door open to studies that would determine whether treatment with COX-2 inhibitors might somehow affect tumor progression"
• Anti-Inflammatory Vioxx (Rofecoxib) May Raise Blood Pressure, No Such Increase Seen With Celebrex (Celecoxib) - Doctor's Guide, 3/20/01
• Studies Target Link Between COX-2 and Ovarian Cancer - Doctor's Guide, 3/8/01
• Celebrex (Celecoxib) Effective In Treating Ankle Sprains - Doctor's Guide, 3/6/01
• Differentiating Coxibs From Nonsteroidal Anti-Inflammatory Drugs - Doctor's Guide, 2/19/01
• Cox 2 Drugs, Biologic Therapy Agents Usher New Era Of Arthritis Treatment - Doctor's Guide, 2/18/01 - "The advantage is not so much that they work better but they are much safer. In terms of GI (gastrointestinal) tract, they have a much lower incidence of causing ulcers and complications of ulcers, such as bleeding, perforation, obstruction etc."
• FDA Warned About Arthritis Drug - Intelihealth, 2/8/01
• FDA action could give boost to Celebrex, Vioxx - USA Today, 2/6/01
• Rofecoxib's Gastrointestinal Toxicity Reviewed - Doctor's Guide, 1/24/01
• COX-2 Inhibition - Oncology Findings - Doctor's Guide, 12/7/00
• Recent Gastrointestinal Outcomes With COX-2 Specific Inhibitors -- Clinical Implications - Doctor's Guide, 12/7/00
• Differentiating Between COX-2 Specific Inhibitors - Doctor's Guide, 12/7/00
• COX-2-specific Inhibition In Musculoskeletal Pain And Inflammation - Clinical Update - Doctor's Guide, 12/7/00
• Drugs Usher in Era of Hope for Rheumatoid Arthritis Sufferers, New Drugs May Even Prevent Joint Damage - WebMD, 11/29/00
• Rofecoxib Proves More Effective Than Celecoxib And Acetaminophen For Knee Pain - Doctor's Guide, 11/3/00
• Vioxx (Rofecoxib) Significantly Reduces Pain After Dental Surgery - Doctor's Guide, 11/3/00
• Better Gastrointestinal Profile For Rofecoxib Than Naproxen In Rheumatoid Arthritis - Doctor's Guide, 11/1/00
• Celebrex (Celecoxib) Comparable To Vioxx (Rofecoxib) In Osteoarthritis Treatment - Doctor's Guide, 10/30/00
• Side-Effect Warning For Novel Arthritis Drug - Intelihealth, 10/10/00
• Arthritis Drug Easy on the Stomach, Study Confirms - WebMD, 9/12/00
• Celecoxib Not Associated With GI Toxicity, Increased Cardiovascular Risk Seen With Conventional NSAIDs - Doctor's Guide, 7/10/00
• Rofecoxib Associated With Greater Blood Pressure Increases And Oedema Than Celecoxib - Doctor's Guide, 7/10/00
• No Significant Differences In Adverse Effects Between Vioxx (Rofecoxib) And Celecoxib For Osteoarthritis - Doctor's Guide, 6/23/00
• Celebrex (Celecoxib) For Arthritis Shows No Increased Risk For Thromboembolic Or Cardiovascular-Related Events - Doctor's Guide, 6/22/00
• Vioxx (Rofecoxib) Reduces Night-Time Osteoarthritis Pain Better Than Celecoxib Or Acetaminophen - Doctor's Guide, 6/22/00
• Osteoarthritis Drug Celebrex (Celecoxib) Less Likely To Cause Increased Blood Pressure Than Vioxx (Rofecoxib) - Doctor's Guide, 6/22/00
• COX-2 Inhibitors Show Good Pain Relief, Safety Record - Doctor's Guide, 6/2/00
• No Link Between GI Complications And Celebrex (Celecoxib) - Doctor's Guide, 5/23/00
• Cardiovascular safety profile of Vioxx (rofecoxib) confirmed - Doctor's Guide, 5/1/00
• Celebrex (Celecoxib) Not Associated With Increases In Stroke Or Heart Attacks - Doctor's Guide, 4/28/00
• Long-Term Celebrex (Celecoxib) Safer than Ibuprofen or Diclofenac For Arthritis - Doctor's Guide, 4/17/00
• Mobic (Meloxicam) Approved in US for Osteoarthritis - Doctor's Guide, 4/14/00
• Some Drugs May Protect Against Alzheimer's, Others Might Increase Risk - Doctor's Guide, 4/12/00
• Study Shows Celecoxib Not Useful In Preventing Alzheimer's Dementia - Doctor's Guide, 4/10/00
• Celebrex (Celecoxib) Once-Daily For Osteoarthritis As Effective As Twice-Daily Dose - Doctor's Guide, 4/6/00
• Vioxx (Rofecoxib) Causes Fewer GI Events Than Naproxen In Rheumatoid Arthritis Patients - Doctor's Guide, 3/27/00
• No Drug Reactions In Aspirin-Sensitive Patients Taking COX-2 Inhibitors, Says Researcher - Doctor's Guide, 3/6/00
• Platelet Function In Osteoarthritis Patients Is Not Affected By Celebrex - Doctor's Guide, 2/15/00
• Serendipity And Hope In War On Cancer - Intelihealth, 1/18/99
• FDA Approved Celebrex In Adjunct Therapy For Familial Adenomatous Polyposis - Doctor's Guide, 12/23/99
• Vioxx, For OA Symptoms, Has Fewer GI Problems When Compared To NSAIDs - Doctor's Guide, 11/23/99
• Rofecoxib Has Fewer GI Side Effects Than NSAIDs In OA Patients  - Doctor's Guide, 11/23/99
• Celecoxib Effective In Rheumatoid Arthritis, With Fewer Ulcers Than Naproxen - Doctor's Guide, 11/23/99
• Rofecoxib Requires Less GI Intervention In Osteoarthritis Patients - Doctor's Guide, 11/18/99
• Osteoarthritis Patients Taking Vioxx Experience Fewer GI Complications - Doctor's Guide, 11/17/99
• Celecoxib Safer Than Traditional Analgesics For Chronic Conditions - Doctor's Guide, 11/17/99
• Celebrex Well Tolerated Across Wide Range Of Studied Doses - Doctor's Guide, 11/16/99
• Celebrex Helps Ease Arthritis Symptoms In Elderly Patients - Doctor's Guide, 11/16/99
• Celebrex Provides Relief From Post-Operative Pain - Doctor's Guide, 10/25/99
• Celecoxib As Effective As Naproxen In Relieving Hip Pain - Doctor's Guide, 10/25/99
• Celecoxib Reduces Number And Size Of Colorectal Polyps - Doctor's Guide, 10/21/99
• Upper GI Healing Unaffected By COX-2 Inhibitors, At Least For Erosions - Doctor's Guide, 10/19/99
• Osteoarthritis Drug, Vioxx, Relieves Menstrual Pain - Doctor's Guide, 10/19/99
• COX-2 Inhibitors Shown Effective For Reducing Risk of Colon Cancer - Doctor's Guide, 10/18/99
• COX-2 Inhibitors Have Fewer GI Side Effects Than Other NSAIDs - Doctor's Guide, 10/18/99
• FDA Grants Priority Review For New Indication For Celebrex For Use In FAP - Doctor's Guide, 9/2/99
• Celebrex Effective In RA, OA Without Affecting Platelet Function, Clotting - Doctor's Guide, 6/9/99
• Vioxx Now Available In U.S. For Menstrual Pain, Osteoarthritis - Doctor's Guide, 6/9/99
• Searle & Pfizer Refute Merck's Claims About Benefits Of Vioxx - Doctor's Guide, 6/9/99
• FDA Approves Vioxx For Osteoarthritis, Acute Pain In Adults And Menstrual Pain - Doctor's Guide, 5/21/99
• Vioxx Causes Significantly Fewer Ulcers Than Standard NSAIDs - Doctor's Guide, 5/17/99
• Searle Responds to Journal Report On Celebrex Side Effects - Doctor's Guide, 4/22/99
• Report Submitted To FDA On Risks Linked To Celebrex - Doctor's Guide, 4/21/99
• Vioxx As Effective As High-Dose Traditional Medications For Acute Pain - Doctor's Guide, 3/18/99
• Rofecoxib As Effective As NSAIDs For Pain, Inflammation - Doctor's Guide, 2/25/99
• Celebrex Now Available In The U.S. For Arthritis Treatment - Doctor's Guide, 2/23/99
• FDA Approves Celebrex For Osteoarthritis And Rheumatoid Arthritis - Doctor's Guide, 1/4/1999
• FDA approves first drug in new class of painkillers - CNN, 12/31/98
• Studies Show Vioxx Does Not Damage Gastrointestinal Tract - Doctor's Guide, 10/13/98
• Vioxx Enables Arthritis Patients To Better Carry Out Daily Activities - Doctor's Guide, 9/8/98
• Vioxx Relieves Dental, Menstrual And Arthritis Pain - Doctor's Guide, 4/21/98

Related Searches:

• Doctor's Guide search of COX-2 inhibitor
• Doctor's Guide (2) search of COX-2
• Intelihealth search of cox-2
• Life Extension Foundation search
• Medline search of COX-2 inhibitor
• Medscape search of COX-2 inhibitor
• Google search of COX-2
• The Natural Pharmacist search of cox-2
• Nutrition Science News search
• WebMD search of COX-2 inhibitor

Related Sites:

• Celebrex.com
• Vioxx.com

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