|
|
|
Home >
Anti-aging Research > L-Glutamine
L-Glutamine
Specific Recommendations:
News & Research:
-
Supplement May Ease Sickle Cell Pain - WebMD, 7/18/18 -
"Endari, a medicine-grade version of the dietary
supplement L-glutamine, reduced sickle cell patients' number of acute pain
crises by 25 percent compared with a placebo ... In addition, the supplement
reduced hospitalizations by one-third" - See
l-glutamine at Amazon.com
 .
-
Glutamine Supplements Show Promise In Treating Stomach Ulcers - Science
Daily, 5/15/09 - "the amino acid glutamine, found in
many foods as well as in dietary supplements, may prove beneficial in
offsetting gastric damage caused by H. pylori infection ... at
six-weeks-post infection, the animals exhibited increased expression of
three cytokines – interleukin 4, interleukin 10 and transforming growth
factor-alpha mRNA. "These all play an important role in the stomach's
ability to protect against damaging effects resulting from other responses
to H. pylori infection ... Of even greater significance, by week 20, the
study results showed that, among the H. pylori-infected animals, the mice
that were fed the L-glutamine diet exhibited lower levels of inflammation
than did the mice that received the standard control diet"
-
Glutamine Independently Reduces Hospital Stay - Doctor's Guide, 10/25/05
- "The nutrient glutamine, which is often
administered as part of nutritional supplementation, on its own can reduce
the length of hospital stay and maintains lean body mass after elective
surgery"
-
Ask Dr. J - Dr. Janson, 4/02 -
"L-glutamine is an amino acid that helps heal the
lining of the entire digestive tract, so it is useful for inflammatory bowel
disease as well as esophagitis"
- Concepts and
Controversies in Nutrition, Immune-Enhancing Formulas
- Medscape, 3/21/02 -
"Immune-enhancing formulas (IEFs), also known as
immune-modulating formulas, include
arginine, glutamine, nucleic acids, and
omega-3 fatty acids"
-
Glutamine Helps Treat AIDS - Nutrition Science News, 9/00
- 'Building
Blocks of Life' Might Help Pump You Up - WebMD, 7/28/00 -
"during exercise, one particular amino acid --
glutamine -- is depleted in the blood supply. Glutamine is involved in
keeping the immune system healthy to ward off illness"
-
Immune-Enhancing Therapy Shortens Hospital Stays By Three Days -
Doctor's Guide, 12/23/99 - "Our study shows that
immunonutrition can make a significant contribution to reducing the number
of infections and length of hospital stay in critically ill patients"
-
Essential Nutrients for Endurance Athletes - Nutrition Science News,
5/99 - "In the seven days following the exercise, 81
percent of the glutamine-supplemented group were infection-free compared to
49 percent in the placebo group."
Abstracts:
-
Preventive Effects of
l-Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation
of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in
Rats - J Agric Food Chem 2022 Sep 19 - "The results
demonstrated that Gln administration reduced body weight, improved serum lipids,
and decreased glucose tolerance in HFD-fed rats. Meanwhile, Gln administration
alleviated liver injury, reduced the hepatic inflammatory response by inhibiting
NLRP3 inflammasome activation, and decreased hepatic lipid accumulation by
promoting VLDL secretion and fatty acid β-oxidation, as well as reduced bile
acid synthesis by activating hepatic and ileal FXR in HFD-fed rats. Moreover,
Gln administration restored HFD-induced intestinal barrier dysfunction, promoted
intestinal fat absorption, suppressed intestinal inflammation, and also reshaped
the gut microbiota composition in HFD-fed rats by downregulating the abundance
of potential pathogens Escherichia-Shigella and upregulating the abundance of
beneficial bacteria such as Akkermansia. To conclude, the present results showed
that Gln may be a potential option for preventing HFD-induced metabolic
disorders via the gut-liver axis" - See
l-glutamine at Amazon.com.
-
Glutamine prevents acute
kidney injury by modulating oxidative stress and apoptosis in tubular epithelial
cells - JCI Insight 2022 Sep 15 - "Acute kidney injury (AKI) represents a
common complication in critically ill patients that is associated with increased
morbidity and mortality. In a murine AKI model induced by
ischemia-reperfusion-injury (IRI), we show that glutamine significantly
decreases kidney damage and improves kidney function ... Glutamine
administration attenuated kidney damage in vivo during AKI and TEC viability in
vitro under inflammatory or hypoxic conditions"
-
Real-World data on efficacy
of L-glutamine in preventing sickle cell disease-related complications in
pediatric and adult patients - Front Med (Lausanne) 2022 Aug 1 -
"L-glutamine has been shown to play an important role in
the regulation of oxidative stress which is one of the key contributors to the
pathophysiology of sickle cell disease (SCD). In a Phase 3 clinical trial,
L-glutamine demonstrated a significant reduction in SCD-related complications
including vaso-occlusive crises (VOCs), hospitalizations, and acute chest
syndrome (ACS) compared to placebo in patients with SCD ... Compared to
baseline, patients had significantly fewer pain crises (median change from 3.0
to 0.0; P < 0.00001), hospitalizations (median change from 3.0 to 0.0; P <
0.00001), days of hospitalization (median change from 15.0 to 0.0; P < 0.00001),
and blood transfusions (median change from 3.0 to 0.0; P < 0.00001) at 24, 48,
and 72 weeks following L-glutamine therapy. Moreover, there was a drastic
decrease in the number of ACS events during this time. A significant increase
was observed in mean hemoglobin levels and hematocrit proportions from baseline
to 72 weeks (P < 0.001). Conversely, compared to baseline, mean reticulocyte
counts and lactate dehydrogenase (LDH) levels were considerably lower at
follow-up time points (P = 0.003 and P < 0.001, respectively). No patient
reported treatment-related adverse events" - See
L-glutamine at Amazon.com.
-
Glutamine-stimulated in
vitro hypertrophy is preserved in muscle cells from older women - Mech
Ageing Dev. 2020 Mar 3 - "Age-related loss of muscle
mass may result from reduced protein synthesis stimulation in response to
anabolic stimuli, such as amino acid (AA) supplementation. The exact etiology of
anabolic resistance to AA remains unclear ... Altogether, our data support the
idea that the intrinsic capacity of muscle cells to respond to glutamine
stimulation is preserved in healthy older women"
-
Oral Supplementation of
Glutamine Attenuates the Progression of Nonalcoholic Steatohepatitis in C57BL/6J
Mice - J Nutr. 2017 Nov;147(11):2041-2049 -
"Universally accepted therapeutic strategies for the treatment of nonalcoholic
steatohepatitis (NASH) are still lacking. Studies suggest a preventive effect of
oral Gln supplementation on the development of NASH ... The liver histology
scores significantly increased from 8 to 13 wk (+31%) in WSD-fed mice and were
significantly higher than in controls (P ≤ 0.05 for both time comparisons),
whereas scores did not differ between C diet-fed and WSD + Gln-fed mice after 13
wk of feeding" - [Nutra
USA]
-
Is glutamine
deficiency the link between inflammation, malnutrition, and fatigue in cancer
patients? - Clin Nutr. 2015 Jan 10 - "The data
support our working hypothesis that in cancer patients systemic inflammation
maintains a catabolic situation leading to malnutrition symptoms and glutamine
deprivation, the latter being associated with cancer related fatigue"
-
Effect of
Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major
Surgery: Systematic Review and Meta-Analysis - Nutrients. 2015 Jan
9;7(1):481-499 - "GLN supplementation did not affect
overall morbidity (RR = 0.84, 95% CI 0.51 to 1.36; p = 0.473) and infectious
morbidity (RR = 0.64; 95% CI = 0.38 to 1.07; p = 0.087). Patients treated with
glutamine had a significant reduction in length of hospital stay (WMD = -2.67;
95% CI = -3.83 to -1.50; p < 0.0001)" - Note: I don't understand
why they're saying that it had no affect on overall morbidity and infection
morbidity with a relative risk of 0.84 and 0.64 respectively. See
glutamine at Amazon.com.
-
Glutamine
supplementation favors weight loss in nondieting obese female patients. A pilot
study - Eur J Clin Nutr. 2014 Sep 17 - "Glutamine supplementation improves
insulin sensitivity in critically ill patients, and prevents obesity in animals
fed a high-fat diet. We hypothesized that glutamine supplementation favors
weight loss in humans. Obese and overweight female patients (n=6) were enrolled
in a pilot, cross-over study ... patients were randomly assigned to 4-week
supplementation with glutamine or isonitrogenous protein supplement (0.5 g/KgBW/day).
During supplementation, patients did not change their dietary habits nor
lifestyle ... Body weight and waist circumference significantly declined only
after glutamine supplementation (85.0±10.4 Kg vs 82.2±10.1 Kg, and 102.7±2.0 cm
vs 98.9±2.9 cm, respectively; P=0.01). Insulinemia and HOMA-IR declined by 20%
after glutamine, but not significantly so"
-
Glutamine
modifies immune responses of mice infected with porcine circovirus type 2 -
Br J Nutr. 2013 Jan 28:1-8 - "Taken together, the
present results suggest that dietary l-glutamine supplementation enhances immune
function in PCV2-infected mice"
-
Glutamine in
the ICU: Who needs supply? - Clin Nutr. 2012 Dec 14 -
"Many ICU patients are glutamine depleted and have low
glutamine plasma concentrations. Beneficial effects by glutamine supply could be
proven in these patients. In some medical conditions, especially those with
acute right heart failure, elevated glutamine plasma concentrations are present
and glutamine supply may be disastrous and a toxic burden. It will be prudent to
reassess the use of glutamine in ICU especially in conditions with unresolved
shock or right heart failure"
-
Time to
wound closure in trauma patients with disorders in wound healing is shortened by
supplements containing antioxidant micronutrients and glutamine: A PRCT -
Clin Nutr. 2012 Jan 25 - "20 trauma patients with
disorders in wound healing were orally supplemented with antioxidant
micronutrients (ascorbic acid, α-tocopherol, β-carotene, zinc, selenium) and
glutamine (verum) or they received isoenergetic amounts of maltodextrine
(placebo) for 14 days ... Wound closure occurred more rapidly in the verum than
in the placebo group (35 +/- 22 vs. 70 +/- 35 d; P = 0.01)"
-
Glutamine in
critical illness: the time has come, the time is now - Crit Care Clin. 2010
Jul;26(3):515-25 - "Glutamine (GLN) has been shown to be
a key pharmaconutrient in the body's response to stress and injury. It exerts
its protective effects via multiple mechanisms, including direct protection of
cells and tissue from injury, attenuation inflammation, and preservation of
metabolic function. Data support GLN as an ideal pharmacologic intervention to
prevent or treat multiple organ dysfunction syndrome after sepsis or other
injuries in the intensive care unit population. A large and growing body of
clinical data shows that in well-defined critically ill patient groups GLN can
be a life-saving intervention"
-
The role of parenteral
glutamine supplement for surgical patient perioperatively: result of a
single center, prospective and controlled study - Langenbecks Arch Surg.
2008 Aug 20 - "In terms of morbidity, there was no
difference between the two groups, but two patients in the control group had
wound infection; none was noted in the Gln group (p = 1.0). No surgical
mortality was noted in this study. CONCLUSIONS: Perioperative parenteral
nutrition supplemented with Gln is beneficial for patients undergoing GI
surgery. Gln supplementation significantly attenuated postoperative
inflammation and ameliorated postoperative immunodepression as well as
nutritional depression in GI surgery"
-
Glutamine: role in critical illness and ongoing clinical trials - Curr
Opin Gastroenterol. 2008 Mar;24(2):190-7 - "Severe
glutamine deficiencies occur rapidly in critical illness. The magnitude of
glutamine deficiency is correlated with ICU mortality. Further, metaanalysis
reveals glutamine reduces morbidity and mortality in critical illness"
-
Glutamine supplementation increases postprandial energy expenditure and fat
oxidation in humans - JPEN J Parenter Enteral Nutr. 2006
Mar-Apr;30(2):76-80
-
Glutamine, exercise and immune function. Links and possible mechanisms -
Sports Med. 1998 Sep;26(3):177-91
|
|
