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Recent Longevity News for the seven days ending 2/20/08.  You should consult your doctor if you are taking any medications.

Overweight And Obese Men Have Lower PSA Values, Even Before They Get Prostate Cancer - Science Daily, 2/19/08 - "mildly obese men's PSA scores were fourteen percent lower than normal-weight men, and moderately and severely obese men had 29 percent lower PSA values ... Doctors have proposed that overweight and obese men have lower PSA scores because their bodies have a greater volume of blood"

Before A CT Scan Or Angiogram, Many People Should Take Inexpensive Drug To Protect Kidneys - Science Daily, 2/18/08 - "The inexpensive drug, called N-acetylcysteine, can prevent serious kidney damage that can be caused by the iodine-containing "dyes" that doctors use to enhance the quality of such scans ... N-acetylcysteine is already widely used to clear mucus in cystic fibrosis patients, and to treat overdoses of acetaminophen" - See n-acetyl cysteine at Amazon.com.

Half Of Heart Patients Significantly Underuse Effective Heart Medications, Many Because Of Cost - Science Daily, 2/18/08 - "American College of Cardiology/American Heart Association guidelines recommend heart attack patients receive treatment with a beta-blocker, a statin cholesterol-lowering drug, an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB), and aspirin. A combination of the drugs has reduced coronary heart disease death by 80 percent compared to placebo"

Prostate Cancer Treatment Can Be Risky - WebMD, 2/18/08 - "men who got ADT were 17% more likely to die than those who opted for close observation ... It's possible that the men who received ADT got the treatment because of rising PSA levels, indicating worse disease ... But it's also possible that hormone therapy, which has been associated with heart disease, osteoporosis, and other health problems, could have compromised survival"

New Clue on Brain Problems and Diabetes - WebMD, 2/18/08 - "Too much of a stress-related hormone may be at the root of memory and other common brain-related diabetes complications ... increases in the stress hormone caused a drop in brain cell regeneration and a decline in memory formation in the rats. But normalizing the levels of the stress hormone reversed many of these negative effects and restored relatively normal brain function, regardless of changes in insulin production" - They are talking about cortisol.  See the 2/17/08 Science Daily article below.  I've been stressing the importance of keeping cortisol under control since the beginning of my website about 10 years ago.  See my home page (item 22) and cortisol page.  There has been a lull in news on it though.  Also see my cortisol page for ways to reduce it.  Phosphatidylserine is supposed to reduce cortisol by 30% but I can't find anything that tells you for how long.  If it reduces it by 30% for 20 minutes it probably isn't worth it.  If it's for 24 hours then it's a good deal even though phosphatidylserine is expensive.  If anyone finds a graph on it, please forward it to me.

Probiotic Cuts Respiratory Illness Rates In Endurance Athletes, Study Suggests - Science Daily, 2/18/08 - "The probiotic Lactobacillus substantially cuts the rate and length of respiratory illness in professional long distance runners ... athletes taking the probiotic had less than half the number of days of symptoms of their colleagues taking the placebo ... Respiratory symptoms while taking Lactobacillus lasted 30 days compared with 72 days while taking the placebo" - [Nutra USA] - See my favorite Garden of Life, Primal Defense at Amazon.com.

Nutrients to Nip Heart Risk? - Dr. Weil, 2/18/08 - "To lower your homocysteine levels you should first reduce the amount of animal foods in your diet. Beyond that, your main strategies should be to make sure that you get plenty of vitamins B6, B12 and folate from your diet and from supplements. I recommend taking a daily multivitamin supplement that provides 400 mcg of folic acid as well as at least 50 mg of vitamin B6. It should also give you 50 mcg of B12 along with the other B vitamins. However, since B12 isn't always well absorbed through the stomach, you might consider taking it in spray form or sublingually (tablets that dissolve under the tongue)"

Lipoic acid and carnitine combo show diabetes potential - Nutra USA, 2/18/08 - [Abstract] - "the combination of LA and LCAR increased the mass, oxygen consumption, mitochondrial DNA expression, and fatty acid oxidation in the fat cells ... However, the treatments with LA or ALC alone at the same concentrations showed little effect on mitochondrial function and biogenesis ... Lipoic acid and acetyl-L-carnitine have become very hot after our reports on the complementary effects on improving memory and ambulatory activity in old rats" - See acetyl l-carnitine products at Amazon.com and alpha lipoic acid at Amazon.com.

Statins, NSAIDs vs. Prostate Cancer - WebMD, 2/18/08 - "Men with prostate cancer who take cholesterol-lowering statin drugs or anti-inflammatory drugs live longer than those who don't take the drugs ... men who reported ever taking statins were 41% to 65% less likely to die during the course of the study than men who didn't. Men who took NSAIDs were 53% to 61% less likely to die than those who didn't"

Stress Hormone Impacts Memory, Learning In Diabetic Rodents - Science Daily, 2/17/08 - "A new study in diabetic rodents finds that increased levels of a stress hormone produced by the adrenal gland disrupt the healthy functioning of the hippocampus, the region of the brain responsible for learning and short-term memory. Moreover, when levels of the adrenal glucocorticoid hormone corticosterone (also known as cortisol in humans) are returned to normal, the hippocampus recovers its ability to build new cells and regains the "plasticity" needed to compensate for injury and disease and adjust to change"

Finding the Right Prostate Cancer Diet - WebMD, 2/15/08 - "poultry and eggs double the risk of prostate cancer progression ... orange and yellow vegetables, such as squash, yams, and carrots, and cruciferous vegetables, such as broccoli, cut the risk of recurrence by about half ... If you eat chicken or poultry, eat it without the skin ... the men's overall PSA doubling time was nearly four times slower after they began drinking pomegranate juice"

Low Vitamin B12 in Pregnancy Linked to Insulin Resistance in Offspring - Medscape, 2/15/08 - "Low plasma vitamin B12 in the first trimester and high folate levels in the second trimester of pregnancy predispose offspring to insulin resistance ... An imbalance in the vitamin B12 and folic acid levels produces the "undesirable effects,""

Science stacks up for choline's health benefits - Nutra USA, 2/15/08 - "the highest average intake of choline (above 310 mg per day) was associated with CRP, IL-6, and TNF-alpha levels 22, 26 and six per cent lower, respectively, than in people with the lowest average intake (less than 250 mg per day)" - [Abstract]

Heavy Cell Phone Use Linked to Cancer, Study Suggests - Science Daily, 2/14/08 - "Those who used a cell phone heavily on the side of the head where the tumor developed were found to have an increased risk of about 50% for developing a tumor of the main salivary gland (parotid), compared to those who did not use cell phones"

Blood Pressure Drug May Also Reduce Risk Of Heart Attack, Stroke, Animal Study Suggests - Science Daily, 2/14/08 - "aliskiren not only lowered blood pressure but also significantly reduced artery-clogging lesions that are the leading cause of heart attack and stroke, the top cause of death worldwide" - I'm still a telmisartan fan until I see more research on renin inhibitors.

Berries and pomegranate - the ultimate Valentine's combo? - Nutra USA, 2/14/08 - "The results of this study demonstrated, for the first time, that daily consumption of PJ for seven weeks caused increased spermatogenic cell density, epididymal sperm concentration, sperm motility and decreased abnormal sperm rate related with decreased lipid peroxidation in male rats ... Forty-seven per cent of subjects reported erections improvements as a result of pomegranate juice, compared to only 32 per cent in the placebo group" - See pomegranate at Amazon.com.

Why Patients Stop Taking Statins and What Can Be Done About It - Medscape, 2/14/08 - "Another reason why patients might stop taking lipid-lowering therapy may be sleep disturbance, which has been associated with statins" - That's something I didn't know.  If you are taking statins, you might want to take them in the morning instead of the evening.

Men Who Are Continually Active At Work May Have Decreased Prostate Cancer Risk, Study Suggests - Science Daily, 2/13/08 - "The message from this study for today is that if you’re more active, you may be able to prevent this cancer from happening"

Fatty Fast Food, Idleness May Vex Liver - WebMD, 2/13/08 - "The students were asked to gain 5% to 15% of their body weight in a month by eating at least two daily meals at fast-food restaurants and adopting a sedentary lifestyle ... On average, the students gained 14 pounds, added 2.6 inches to their waistline, and padded their body fat percentage by 3.7% during the study ... Blood samples provided by the students throughout the study show a spike in levels of the liver enzyme alanine aminotransferase (ALT). ALT levels rose quickly -- typically within a week -- after the students started the fast-food diet"

A Ray Of Sunshine In The Fight Against Cancer: Vitamin D May Help - Science Daily, 2/13/08 - "It sounds too good to be true … a little inexpensive pill that could block the development of some cancers, strengthen bones, prevent multiple sclerosis and alleviate winter depression ... But it’s not science fiction. The “new aspirin” could be Vitamin D ... during the winter, Canadians take at least 1,000 units a day of Vitamin D" - See vitamin D at Amazon.com.

Aspirin Associated With Reduced Colorectal Cancer Risk in Men - Medscape, 2/12/08 - "men who reported regular aspirin use (at least 2 times per week) had a significantly lower risk of colorectal cancer compared with those who were not regular aspirin users (multivariate RR, 0.79) ... However, men reporting 6 to 14 standard aspirin tablets per week had a multivariate RR of 0.72, and those consuming more than 14 tablets per week experienced a multivariate RR of 0.30" - Note: A RR of 0.79 is a 21% reduction, a RR of 0.30 is a 70% reduction.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta A Randomized Cross-Over Study - J Am Coll Cardiol. 2008 Feb 19;51(7):742-749 - "Ramipril reversed the impaired endothelial function and decreased the expression of proinflammatory cytokine IL-6, sCD40L, and adhesion molecules in normotensive subjects with SCR. These findings imply that ramipril treatment may have antiatherogenic effects in subjects with SCR, even in the absence of arterial hypertension" - Note:  Ramipril was my first line choice for combo therapy.

Effect of Co-enzyme Q10 and Alpha-Lipoic Acid on Response of Rabbit Urinary Bladder to Repetitive Stimulation and In Vitro Ischemia - Urology. 2008 Feb 15 - "CoQ10 showed no protective effect. alpha-LA resulted in increased contractile responses of the control bladder and showed a moderate protective effect for all forms of stimulation. The combination, however, showed a significantly greater increase in the contraction of the control bladder and a greater protective effect than alpha-LA alone"

Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels - Diabet Med. 2008 Feb 13 - "Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo ... Vitamin D insufficiency is common in patients with Type 2 diabetes during winter in Scotland. A single large dose of oral vitamin D2 improves endothelial function in patients with Type 2 diabetes and vitamin D insufficiency" - See vitamin D at Amazon.com.

N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats - Br J Pharmacol. 2008 Feb 18 - "NAC markedly reduces the severity of renal dysfunction induced by ifosfamide with a significant decrease in elevations of serum creatinine (57.8+/-2.3 vs 45.25+/-2.1 mumol l(-1)) as well as a reduced elevation of beta(2)-microglobulin excretion (25.44+/-3.3 vs 8.83+/-1.3 nmol l(-1)) and magnesium excretion (19.5+/-1.5 vs 11.16+/-1.5 mmol l(-1)). Moreover, NAC significantly improved the ifosfamide-induced glutathione depletion and the decrease of glutathione S-transferase activity, lowered the elevation of lipid peroxides and prevented typical morphological damages in renal tubules and glomeruli" - See n-acetyl cysteine at Amazon.com.

Lipoic acid and carnitine combo show diabetes potential - Diabetologia. 2008 Jan;51(1):165-74. Epub 2007 Nov 17 - "Treatments with the combination of LA and ALC at concentrations of 0.1, 1 and 10 mumol/l for 24 h significantly increased mitochondrial mass, expression of mitochondrial DNA, mitochondrial complexes, oxygen consumption and fatty acid oxidation in 3T3L1 adipocytes. These changes were accompanied by an increase in expression of Pparg, Ppara and Cpt1a mRNA, as well as increased expression of peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1 alpha (Ppargc1a), mitochondrial transcription factor A (Tfam) and nuclear respiratory factors 1 and 2 (Nrf1 and Nrf2). However, the treatments with LA or ALC alone at the same concentrations showed little effect on mitochondrial function and biogenesis" - See acetyl l-carnitine products at Amazon.com and alpha lipoic acid at Amazon.com.

Fatty acid status and behavioural symptoms of Attention Deficit Hyperactivity Disorder in adolescents: A case-control study - Nutr J. 2008 Feb 14;7(1):8 - "ADHD adolescents consumed more energy and fat than controls but had similar anthropometry. ADHD children consumed equivalent amounts of omega-3 and omega-6 fatty acids to controls, however they had significantly lower levels of docosahexaenoic acid (DHA, 22:6n-3) and total omega-3 fatty acids, higher omega-6 fatty acids and a lower ratio of n-3:n-6 fatty acids than control subjects. In addition, low omega-3 status correlated with higher scores on several Conners' behavioural scales ... These data suggest that adolescents with ADHD continue to display abnormal essential fatty acid profiles that are often observed in younger children and distinctly different from normal controls of similar age. Further these red blood cell fatty acid differences are not explained by differences in intake. This suggests that there are metabolic differences in fatty acid handling between ADHD adolescents and normal controls. The value of omega-3 supplements to improve fatty acid profiles and possibly behaviours associated with ADHD, need to be examined" - See Jarrow Max DHA at Amazon.com and Mega Twin EPA at iHerb.

Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study - Am J Clin Nutr. 2008 Feb;87(2):424-30 - "Compared with the lowest tertile of choline intake (<250 mg/d), participants who consumed >310 mg/d had, on average, 22% lower concentrations of C-reactive protein (P < 0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower concentrations of tumor necrosis factor-alpha" - See citicholine at Amazon.com.

Combined effects of swim training and ginseng supplementation on exercise performance time, ROS, lymphocyte proliferation, and DNA damage following exhaustive exercise stress - Int J Vitam Nutr Res. 2007 Jul;77(4):289-96 - "These findings suggest that the combined effect of swim training and ginseng supplementation sustain lymphocyte function in the presence of reduced ROS production and DNA damage following acute exercise stress"

Erectile Dysfunction in Patients with Hyper- and Hypothyroidism: how Common and Should We Treat? - J Clin Endocrinol Metab. 2008 Feb 12 - "ED was more prevalent in patients with hyperthyroidism and hypothyroidism compared to controls ... ED is extremely common in males with dysthyroidism. Treatment of the latter restores erectile function"

Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder - Aust N Z J Psychiatry. 2008 Mar;42(3):192-8 - "EPA + fluoxetine combination was significantly better than fluoxetine or EPA alone from the fourth week of treatment. Fluoxetine and EPA appear to be equally effective in controlling depressive symptoms. Response rates (>/=50% decrease in baseline HDRS) were 50%, 56% and 81% in the fluoxetine, EPA and combination groups, respectively" - See Mega Twin EPA at Amazon.com.

Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women - Menopause. 2008 Jan-Feb;15(1):125-32 - "When comparing the two treatment groups with the placebo group, there were significant reductions in mean daily hot flash frequency. The supplement (either 40 or 60 mg) reduced hot flash frequency by 43% at 8 weeks (P = 0.1) and 52% at 12 weeks (P = 0.048) but did not cause any significant changes in endogenous sex hormones or thyroid hormones" - See Nature's Way EstroSoy Plus Fermented Soy Extract + Black Cohosh at iHerb.

Dietary salt restriction increases plasma lipoprotein and inflammatory marker concentrations in hypertensive patients - Atherosclerosis. 2008 Feb 8 - "low sodium intake (LSI) ... LSI induced alterations in the plasma lipoproteins and in inflammatory markers that are common features of the metabolic syndrome"

Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus - Diabetes Care. 2008 Feb 11 - "The NAC+ARG administration seems to be a potential well-tolerated antiatherogenic therapy since it improves the endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of the oxidative stress and increase of NO production. Our study's results give prominence to its potential use in the primary and secondary cardiovascular prevention in these patients"

Weight gain and psychiatric treatment: Is there a role for green tea and conjugated linoleic acid? - Lipids Health Dis. 2007 May 3;6:14 - "Here we report on four cases of social anxiety disorder treated with the atypical antipsychotic quetiapine. Self-administration of conjugated linoleic acid and green tea extract may have influenced objective anthropomorphic measurements; each patient had an unexpected decrease in total body fat mass, a decrease in body fat percentage and an increase in lean body mass. Since weight gain is a common and undesirable side-effect with psychiatric medications, our observation strongly suggests the need for controlled clinical trials using these agents" - See green tea extract at Amazon.com and conjugated linoleic acid at Amazon.com.

Effects of conjugated linoleic acid and exercise on bone mass in young male Balb/C mice - Lipids Health Dis. 2006 Mar 23;5:7 - "Conjugated Linoleic Acid (CLA) has been reported to lower body fat mass. However, weight loss is generally associated with negative effects on bone mass, but CLA is reported to have beneficial effects on bone ... a combination therapy of CLA and EX on bone health has not been studied ... although CLA decreased gain in body weight by 35%, it however increased bone mass by both reducing bone resorption and increasing bone formation. EX also decreased gain in body weight by 21% and increased bone mass; but a combination of CLA and EX, however, did not show any further increase in bone mass" - See conjugated linoleic acid at Amazon.com.

N-acetylcysteine for the prevention of postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study - Eur Heart J. 2008 Feb 8 - "The result of this study indicates that NAC treatment decreases the incidence of postoperative AF" - See n-acetyl cysteine at Amazon.com.

Neat Gadgets:

I’ve been seeing this on TV.  It sounds like a must have for people with overseas relatives.  It got PC Magazine Editor's Choice.  You could send one to your relative and they could call unlimited to the US for $19.95/year ($39.95 for the first year to pay for the gadget) or you could bring it with you when traveling overseas and call home for free:

http://www.magicjack.com - for some reason, if you leave out the www (i.e. magicjack.com vice www.magicjack.com) it won't come up.  It brings you to some site in the Neatherlands.

For the basic features see (It’s got free voice mail, caller ID, call forwarding and call waiting):

http://help.magicjack.com/SupportFaq/Browse.aspx

The three way calling only works if the call is incoming though.

See the unbiased reviews at:

http://help.magicjack.com/SupportFaq/Home.aspx

I couldn't tell any difference in voice quality.  See:

Smart Talk at Work and Home - YMax magicJack - Reviews by PC Magazine - "voice quality that's almost indistinguishable from a straight analog POTS line"

I received the magicJack in 2 days and set it up in about a minute. I can’t tell the difference between it and the regular phone as far as voice quality or anything else but make sure you perform the magicFix optimize thing. I’ve very happy with it.  My extra cordless phone hasn’t come in yet from Amazon.com so currently I forwarded my home phone to the magicJack number so I could use magicJack throughout the house with the cordless phones I have and I’ll forward the magicJack to my cell when I’m out. I’m going to switch my regular phone number over to it when that option becomes available and save $40 per month. I’ll just forward the magicJack to my cell phone at night when the computer is off or else let the voice mail handle it.  I use the cell phone as a backup alarm clock anyway plus it's a time chance to recharge it at the same time.

Just for kicks, I activated the overseas prepaid option with $5 on my credit card. That’s almost 3 hours to Taiwan if I were ever to call there.

It will probably be like stamps.com where as soon as it becomes popular they will quadruple the price but even then it would be a great deal.

International rates are cheap.  The last time I checked, a call to Hong Kong was 2 cents per minute.  It costs more than that for local tool calls with AT&T.  If the person in the foreign country has magicJack, calls to the US and Canada are free.  Also if both the foreign user has magicJack and the US caller places an outgoing call via magicJack (magicjack to magicJack) it is free.  For the rates, see http://www.ymaxcorp.com/clec_rates.html.

The magicJack display on the computer screen has a neat call log showing incoming calls in green, outgoing in blue and missed calls in red.

To always have the call forwarding window just a click or two away, in Internet Explorer, I went "Tools - Internet Options" and put the following as Home Page:

http://qualitycounts.com/daily.htm
http://my.magicjack.com/

You could also make it a desktop icon and drag it into Quick Launch.  I did both.  Just bring up http://my.magicjack.com/ and go "File - Send - Shortcut to Desktop" and then drag the desktop icon into Quick Launch.  To change the picture of the icon, right click it and select whatever you want.  You might also want to add it to the Startup Menu.  Go "Start - All Programs" then right click "Startup" and select "Open" and then drag the magicJack desktop icon into that folder.  If you don't do that you need to remember to open that program every time you turn the computer on or the phone won't work.

I’m not affiliated with magicJack but I am with Amazon.com.  If you need a phone to go with it, here is one that tells you who is calling between calls which is great for people like me who need to put on their reading glasses to see the caller ID readout (my affiliate link).  You can expand it up to four phones.  I assume everyone already knows that on the newer cordless phones, only the phone with the answering machine needs to be plugged into a phone jack:

Panasonic KX-TG6052B 5.8 GHz FHSS Expandable Digital Cordless Phone System with 2 Handsets

Actually you can save $1.55 by getting magicJack at Amazon.com (click here).  The magicJack site charges $46.90 with shipping whereas Amazon.com is $45.35 with shipping.  However, I don't think you can beat the shipping speed when ordering it directly.  It took 2 days for me to receive it in San Diego from Florida via USPS.  I ordered it at 4:30 AM on 2/14 and received it on 2/16.

Some of the cons:

  • 3 way calling only works if the call is incoming.
  • You must have your computer on.
  • No 900 number service - you'll have to give up the sex talks with the elderly ladies pretending to be babes.
  • You need a computer for call forwarding.  You can't do it remotely via the telephone.
  • The only way I could see be notified of a voice mail was via email although most people would probably use their own answering machine anyway and just use the voice mail when you are talking on the phone and someone else calls.
  • The number is not listed in the white pages.  So if you transfer you home phone number when that option becomes available, you'll basically have an unlisted number.

Health Focus (Exercise):

Alternative News Regarding Exercise:

News & Research Regarding Exercise:

Affiliates (I could sure use some sales.  You can drag the links onto your desktop and use them so that I get credit for the sale.  Click here for more stores):