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Home > Health Conditions > Hypothyroidism


Popular Medications   Popular Supplements   Alternative News   CME   The T3 Controversy   General Information   Other News   Related Searches   Related Sites

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Alternative News:

  • Chronic fatigue syndrome possibly explained by lower levels of key thyroid hormones - Science Daily, 3/20/18 - "In hypothyroidism, the body tries to encourage thyroid hormone activity by releasing more thyroid-stimulating hormone -- however, this does not happen in patients with chronic fatigue syndrome ... the researchers compared thyroid function and markers of inflammation between 98 CFS patients and 99 healthy controls. Remarkably, the CFS patients had lower serum levels of certain key thyroid hormones such as triiodothyronine (T3) and thyroxine (T4), but normal levels of thyroid-stimulating hormone ... Additional analyses indicated that CFS patients had a lower urinary iodine status and low-grade inflammation, which possibly mirrored the symptoms of patients with hypothyroidism. These CFS patients, however, had relatively higher levels of another thyroid hormone called "reverse T3" or rT3. This appeared to be due to a shift in hormone production, where the body preferred to convert T4 to rT 3 instead of producing T3. The low T3 levels found in CFS patients coupled with this switchover to rT3 could mean that T3 levels are severely reduced in tissue"    
  • L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial - Endocr J. 2016 Jul 16 - "Hypothyroid patients experience fatigue-related symptoms despite adequate thyroid hormone replacement ... 60 patients (age 50.0 ± 9.2 years, 3 males, 57 females) who still experienced fatigue (fatigue severity scale [FSS] score ≥ 36) were given L-carnitine (n = 30, 990 mg L-carnitine twice daily) or placebo (n = 30) for 12 weeks. After 12 weeks, although neither the FSS score nor the physical fatigue score (PFS) changed significantly, the mental fatigue score (MFS) was significantly decreased by treatment with L-carnitine compared with placebo (from 4.5 ± 1.9 to 3.9 ± 1.5 vs. from 4.2 ± 1.8 to 4.6 ± 1.6, respectively; P < 0.01). In the L-carnitine group, 75.0%, 53.6%, and 50.0% of patients showed improvement in the FSS score, PFS, and MFS, respectively, but only 20.0%, 24.0%, and 24.0%, respectively, did so in the placebo group (all P < 0.05). Both the PFS and MFS were significantly improved in patients younger than 50 years and those with free T3 ≥ 4.0 pg/mL by treatment with L-carnitine compared with placebo" - See L-carnitine at Amazon.com.
  • The effect of vitamin a supplementation on thyroid function in premenopausal women - J Am Coll Nutr. 2012 Aug;31(4):268-74 - "Serum TSH concentrations in vitamin A-treated subjects were significantly reduced; therefore, vitamin A supplementation might reduce the risk of subclinical hypothyroidism in premenopausal women"
  • Selenium and the Thyroid: A Close-Knit Connection - J Clin Endocrinol Metab. 2010 Sep 1 - "Maintenance of "selenostasis" via optimal intake not only aids preservation of general health but also contributes substantially to the prevention of thyroid disease" - See selenium at Amazon.com.
  • Effect of Zinc Supplementation on Thyroid Hormone Function. A Case Study of Two College Females - Ann Nutr Metab. 2007 May 30;51(2):188-194 - "Zinc supplementation appeared to have a favorable effect on thyroid hormone levels, particularly total T(3), and RMR"
  • Hypothyroidism More Common than Previously Recognized - New Hope Natural Media, 4/24/03 - "Hypothyroidism can result in a wide array of symptoms, including fatigue, depression, cold hands and feet, dry skin, fluid retention, hair loss, menstrual irregularities, infertility and elevated serum cholesterol"
  • The Importance of Thyroid Supplementation - Life Enhancement Magazine, 11/99

The T3 (triiodothyronine) controversy (also see my triiodothyronine page):

  • Combo Thyroid Hormones as Good as Levothyroxine for Hypothyroidism - Medscape, 3/22/21 - "Patients with hypothyroidism treated with the three most common pharmacological strategies of levothyroxine (LT4) alone, LT4 in combination with triiodothyronine (T3), or desiccated thyroid extract showed no differences in thyroid symptoms or secondary outcomes in a double-blind randomized study ... Additionally, some patients treated with LT4 alone report greater improvements in symptoms with the addition of T3 ... Overall, 45% of patients indicated they preferred desiccated thyroid as their first choice of treatment, 32% preferred LT4/T3 as their first choice, and 23% preferred LT4 alone ... When Switched to Desiccated Thyroid, Many Felt 'Much Better' ... A further exploratory analysis revealed that those who experienced symptoms while taking LT4 alone reported greater alleviation of symptoms with the other two treatments ... However, with the subgroup analysis based on the scores of symptom questionnaires, we found that symptomatic patients on LT4 improved while being treated with LT4/T3 or desiccated thyroid ... Reports of improvements in switching to desiccated thyroid were notable, Hoang added. "Many patients when switched from LT4 to desiccated thyroid extract said they felt much better, [with] more energy, less mental fogginess, a better outlook, less flair of lupus symptoms, easier to lose weight, etc."" - Note:  So why is trying to get a prescription for desiccated thyroid extract or a t4/t3 combo like trying to get a prescription for cocaine?  Lotta old-timer endocrinologists think they know it all when the research doesn't back them up.
  • Serum Triiodothyronine-to-thyroxine (T3/T4) Ratio Predicts Therapeutic Outcome to Biological Therapies in Elderly IBD Patients - Medscape, 2/1/21 - "Baseline T3/T4 ratio was higher in patients with mucosal healing, as compared with those without mucosal healing (P < 0.0001), regardless of the disease type or biological drug (OR 6.4 [2.9–14.3] for each T3/T4 unit increase, P < 0.0001). A cut point of 3.3 was identified as the optimal threshold of baseline T3/T4 ratio for predicting mucosal healing, providing 78% sensitivity and 89% specificity (area under the ROC curve 0.88 [0.79–0.94]; positive and negative likelihood ratios 6.8 [2.9–15.9] and 0.3 [0.1–0.5] respectively) ... T3/T4 ratio seems a reliable tool for predicting therapeutic outcome of biological therapy in elderly patients with IBD"
  • Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study - Clin Endocrinol (Oxf). 2014 Jun 23 - "Like several other known risk factors, serum FT4 levels are associated with carotid-femoral pulse wave velocity, suggesting that high FT4 levels have a detrimental effect on aortic stiffness and may contribute to aging process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy"
  • Associations between thyroid function and mortality: the influence of age - Eur J Endocrinol. 2014 May 6 - "AS FOR THYROID FUNCTION WITHIN THE NORMAL RANGE: in the 493 participants aged 80 years or older, a FT4 level in the high-normal range (18.5-22 pmol/l) was associated with a higher mortality in comparison to FT4 levels in the middle range (11.5-15.0 pmol/L): HR 1.7 (95% CI 1.0-2.9). In these elderly, also TSH levels within the high-normal range (3.0-4.0 mIU/L) were associated with a higher mortality in comparison to TSH levels within the middle range (1.0-2.0 mIU/L)"
  • Higher Free Thyroxine Levels Predict Increased Incidence of Dementia in Older Men: The Health In Men Study - J Clin Endocrinol Metab. 2012 Sep 13 - "Men who developed dementia had higher baseline FT(4) (16.5 +/- 2.2 vs. 15.9 +/- 2.2 pmol/liter, P = 0.004) but similar TSH (2.2 +/- 1.4 vs. 2.3 +/- 1.6 mU/liter, P = 0.23) compared with men who did not receive this diagnosis. After adjusting for covariates, higher FT(4) predicted new-onset dementia (11% increased risk per 1 pmol/liter increase in FT(4), P = 0.005; quartiles Q2-4 vs. Q1: adjusted hazard ratio = 1.76, 95% confidence interval = 1.03-3.00, P = 0.04). There was no association between TSH quartiles and incident dementia. When the analysis was restricted to euthyroid men (excluding those with subclinical hyper- or hypothyroidism), higher FT(4) remained associated with incident dementia (11% increase per unit increment, P = 0.03; Q2-4 vs. Q1: adjusted hazard ratio = 2.02, 95% confidence interval = 1.10-3.71, P = 0.024)" - Note:  There is also an association with a low T3/T4 ration and insulin resistance.  I alternate between taking T4 on day and T3 the next.  Doctor's seem to refuse to prescribe both. 
  • T3 augmentation of SSRI resistant depression - J Affect Disord. 2006 Apr;91(2-3):211-5 - "The women took a mean daily dose of 40.6 mug of T3 for a mean duration of 3.75 weeks, while the men were on a mean daily dose of 43.8 mug of T3 for 3.5 weeks. T3 augmentation was associated with a statistically significant drop (p<.003) in the mean HAMD at end of the three weeks compared to baseline scores"
  • T3 augmentation of SSRI resistant depression - J Affect Disord. 2006 Feb 14 - "T3 augmentation was associated with a statistically significant drop (p<.003) in the mean HAMD at end of the three weeks compared to baseline scores ... T3 augmentation resulted in improvement of mood scores"
  • Combinination Levothyroxine/Liothyronine Shows No Obvious Benefit Over Levothyroxine Alone in Patients With Primary Hypothyroidism - Doctor's Guide, 12/11/03 - "Patients who are treated with a combination of levothyroxine plus liothyronine for primary hypothyroidism gained no apparent benefit compared with patients treated with levothyroxine monotherapy"
  • Combination Therapy No Better Than T4 Alone for Primary Hypothyroidism - Medscape, 12/9/03
  • Use OF T3 Thyroid Hormone to Treat Depression - DrMirkin.com, 5/19/01 - "some people become depressed when they take just T4 and their depression can be cured when they take both thyroid hormones, T3 and T4"
  • T3---fibromyalgia, hypothyroidism, thyroid hormone resistance - drlowe.com
  • Wilson's Thyroid Syndrome - "Conversion of T4 to T3 can also be impaired by glucocorticoids" - Maybe that is the mechanism by which cortisol causes depression, and if so, could T3 then cure the depression? - Ben
  • Thyroid Hormone Replacement Therapy - Horm Res 2001 Jan;56 Suppl S1:74-81 - "Desiccated thyroid contains both thyroxine (T(4)) and triiodothyronine (T(3)); serum T(3) frequently rises to supranormal values in the absorption phase, associated with palpitations. Liothyronine (T(3)) has the same drawback and requires twice-daily administration in view of its short half-life ... recent animal experiments indicate that only the combination of T(4) and T(3) replacement, and not T(4) alone, ensures euthyroidism in all tissues of thyroidectomized rats ... It could well be that a slow-release preparation containing both T(4) and T(3) might improve the quality of life, compared with T(4) replacement alone, in some hypothyroid patients"
  • Adding Natural Hormone Boosts Brain Function In Hypothyroidism - Doctor's Guide, 2/11/99
  • T3 Triiodothyronine Drugs Improve Quality of Life for Hypothyroidism - thyroid-info.com
  • Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism - N Engl J Med. 1999 Feb 11;340(6):469-70 - "among 15 visual-analogue scales used to indicate mood and physical status, the results for 10 were significantly better after treatment with thyroxine [t4] plus triiodothyronine [t3]"
  • Depression Management - ContinuingEducation.com, exp. 12/31/02 - See table six, recommends 5 - 50 mcg T3, 100 mcg (.1 mg) T4

Other News: