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Home > Health
Conditions > Female Sexuality
Female Sexuality/Sexual Arousal Disorder
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-
DHEA on sexual function in
Sheehan Syndrome: A randomized double-blind placebo-controlled cross-over trial
- J Clin Endocrinol Metab 2022 Apr 27 - "Majority of
women with Sheehan syndrome (SS) suffer from sexual dysfunction. Severe androgen
deficiency is a major contributory factor. DHEA supplementation has been
reported to have variable efficacious in improving female sexual dysfunction
(FSD) in several trials ... DHEA supplements (25mg twice daily) or matched
placebo ... There was significant improvement in FSFI score from baseline to end
of the study in the DHEA group as compared to the placebo group (p=0.006). Mean
FSFI score and most of the individual domains of FSD improved with DHEA
significantly in both groups (p=0.001 for each group with DHEA). Those who
received DHEA first followed by placebo, FSFI declined significantly after
placebo (p=0.041), but remained at an acceptable level of sexual functioning.
Serum DHEAS increased significantly with DHEA treatment. No significant changes
in glycemic index, lipid profile and liver enzymes were noted with DHEA
treatment" - See Pure
Encapsulations DHEA 25 mg at Amazon.com.
-
Safety and influence
of a novel extract of fenugreek on healthy young women: a randomized,
double-blinded, placebo-controlled study - Clinical Phytoscience volume 7,
Article number: 63 (2021) - "Earlier studies have shown
that the hydro-ethanolic extracts of fenugreek are efficient in the management
of a number of hormone related disorders in women, including post and peri-menopausal
discomforts, sexual dysfunctions, lactation and even in amenorrhea ...
Forty-eight healthy menstruating women aged 20 to 48 were randomized either to
FHE (n = 24) or placebo (n = 24) and supplemented with 250 mg × 2/day for
42 days. FHE did not produce any side effects or adverse events. It offered
significant (P < 0.05) beneficial effects to sexual problems (41.6%) and
irritability (40%) among the participants who had higher sexual dysfunctions
scores (> 1) when monitored by the validated Menopausal Rating Scale (MRS)
scale. Further, hormone analysis indicated an enhancement in estradiol (P
= 0.040), free testosterone (P = 0.025), and total testosterone (P = 0.012) in
FHE group in comparison to placebo. There were no significant changes in
progesterone (P = 0.174) and FSH (P = 0.879) upon FHE supplementation. The
hematological and biochemical safety parameters were also at par with the safety
of the extract" - [Nutra
USA] - See fenugreek at Amazon.com and
iHerb.
-
DHEA Improves Sexual
Function in Some Premenopausal Women - Medscape, 10/10/18 -
"Androgen
supplementation with dehydroepiandrosterone (DHEA) significantly improves sexual
function in premenopausal, infertile women with poor sexual function ...
assessed 50 premenopausal women who were older (average age, 41 years) and
seeking treatment for infertility ... oral DHEA 75 mg once daily ... In the
study cohort, mean FSFI score increased by 7%, with scores for desire, arousal,
and lubrication increasing by 17%, 12%, and 8%, respectively. There were no
changes in scores on the orgasm, satisfaction, or pain domains ... However,
women whose FSFI scores were in the lowest quartile at baseline saw the greatest
benefit, with an average increase of 34% ... And improvement was seen in all
domains of sexual functioning for these women. Increases were 40% for desire,
46% for arousal, 33% for lubrication, 54% for orgasm, 24% for satisfaction, and
25% for pain" - See
DHEA at Amazon.com
 .
-
The effect of low vitamin
D status on sexual functioning and depressive symptoms in apparently healthy
men: a pilot study - Int J Impot Res. 2018 Jul 5 - "Hypovitaminosis
D is associated with sexual dysfunction in apparently healthy women and with
erectile dysfunction in men with the presence of concomitant disorders. This
study was aimed at investigating sexual functioning and depressive symptoms in
young men with low vitamin D status. The study included 15 apparently healthy
men (18-40 years old) with vitamin D deficiency (group A), 16 subjects with
vitamin D insufficiency (group B), and 16 men with normal vitamin D status
(group C) ... Compared with healthy men, subjects with vitamin D deficiency
obtained lower scores for erectile function, orgasmic function, and sexual
desire, while individuals with vitamin D insufficiency lower scores only for
erectile function. Erectile dysfunction was more prominent in group A than group
B. The total BDI-II score was higher in group A than in the other study groups.
The results of the study suggest that low vitamin D status impairs male sexual
functioning and severity of sexual dysfunction correlates with the degree of hypovitaminosis D" - See
vitamin D at Amazon.com.
-
Efficacy of Tribulus
terrestris for the treatment of hypoactive sexual desire disorder in
postmenopausal women: a randomized, double-blinded, placebo-controlled trial
- Menopause. 2016 Oct 10 - "assigned to receive 750 mg/d
of T terrestris or placebo for 120 days ... All participants answered the Female
Sexual Function Index and the Sexual Quotient-female version questionnaires ...
FSFI questionnaire results demonstrated an improvement in all domains in both
groups (P < 0.05) except for lubrication which was improved only in the study
group. QS-F results showed a significant improvement in the domains of desire
(P < 0.01), arousal/lubrication (P = 0.02), pain (P = 0.02), and anorgasmia
(P < 0.01) in women who used T terrestris, whereas no improvement was observed
in the placebo group (P > 0.05). Moreover, free and bioavailable testosterone
levels showed a significant increase in the T terrestris group" - See Tribulus terrestris at Amazon.com.
-
Efficacy of Intravaginal
Dehydroepiandrosterone (DHEA) on Moderate to Severe Dyspareunia and Vaginal
Dryness, Symptoms of Vulvovaginal Atrophy, and of the Genitourinary Syndrome of
Menopause - Medscape, 3/22/16 - "The daily
intravaginal administration of 0.50% (6.5 mg) DHEA (Prasterone) has shown
clinically and highly statistically significant effects on the four coprimary
parameters suggested by the US Food and Drug Administration. The strictly local
action of Prasterone is in line with the absence of significant drug-related
adverse events, thus showing the high benefit-to-risk ratio of this treatment
based upon the novel understanding of the physiology of sex steroids in women"
-
Efficacy and Safety of
Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in
Women: A Pilot Study - Biomed Res Int. 2015;2015:284154 -
"high-concentration ashwagandha root extract (HCARE) ...
subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8
weeks ... treatment with HCARE leads to significantly higher improvement,
relative to placebo, in the FSFI Total score (p < 0.001), FSFI domain score for
"arousal" (p < 0.001), "lubrication" (p < 0.001), "orgasm" (p = 0.004), and
"satisfaction" (p < 0.001), and also FSDS score (p < 0.001) and the number of
successful sexual encounters (p < 0.001) at the end of the treatment" -
[Nutra
USA] -
See
ashwagandha at Amazon.com.
-
Influence of
a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone,
Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised
Placebo Controlled Study - Phytother Res. 2015 Apr 24 -
"Trigonella foenum-graecum (fenugreek) seed extract ...
There was a significant increase in free testosterone and E2 in the active group
as well as sexual desire and arousal compared with the placebo group. The
results indicate that this extract of T. foenum-graecum may be a useful
treatment for increasing sexual arousal and desire in women" - See
fenugreek at Amazon.com.
-
Kava for the
Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions,
Liver Function, Addiction, and Sexual Effects - Phytother Res. 2013 Jan 24 -
"The study design was a 6-week, double-blind, randomized
controlled trial (n = 75) involving chronic administration of kava (one tablet
of kava twice per day; 120 mg of kavalactones per day, titrated in non-response
to two tablets of kava twice per day; 240 mg of kavalactones) or placebo for
participants with generalized anxiety disorder. Results showed no significant
differences across groups for liver function tests, nor were there any
significant adverse reactions that could be attributed to kava. No differences
in withdrawal or addiction were found between groups. Interesting, kava
significantly increased female's sexual drive compared to placebo (p = 0.040) on
a sub-domain of the Arizona Sexual Experience Scale (ASEX), with no negative
effects seen in males. Further, it was found that there was a highly significant
correlation between ASEX reduction (improved sexual function and performance)
and anxiety reduction in the whole sample" - See
kava at Amazon.com.
-
The use of
dehydroepiandrosterone in the treatment of hypoactive sexual desire disorder: A
report of gender differences - Eur Neuropsychopharmacol. 2012 Oct 17 -
"Data regarding the efficacy of dehydroepiandrosterone
(DHEA) in the treatment of hypoactive sexual desire disorder (HSDD) are scarce
and inconsistent. We aimed to determine possible gender differences in the
efficacy of DHEA as a treatment for HDSS. Postmenopausal women (n=27), and men
(n=21) with HSDD, were randomized to receive either DHEA 100mg daily or placebo
for 6 weeks in a controlled, double blind study ... In women only, significant
interaction effects were observed for sexual arousal (p<0.05), satisfaction
(p<0.05), and cognition (trend; p=0.06). For arousal, a significant improvement
was observed for the DHEA treated group at 6 weeks (p=0.001). Significant
correlations were observed between bioavailable T and sexual cognitions, arousal
and orgasm, while DHEAS was correlated with satisfaction. In the men,
significant correlations were observed between testosterone and arousal (r=.45),
sexual drive (r=.50) and orgasm (r=.55). In women with HSDD, DHEA treatment had
a significant beneficial effect on arousal, whereas no efficacy was demonstrated
in men, indicating a possible gender difference. This improvement seems to be
mediated via DHEA's metabolism to testosterone. Our positive results suggest
that the neurosteroid DHEA may be effective as a treatment for women with HSDD
if administered at a dose of at least 100mg per day" - See
DHEA at Amazon.com.
-
Menopause pill may boost sex life - USATODAY.com, 12/20/11 -
"This is the first evidence that low doses of DHEA
(dehydroepiandrosterone), a hormone secreted by the adrenal glands, can help
sexual function as well as menopausal symptoms ... women taking DHEA had a
statistically significant increase in sexual interest and activity, with similar
results for women in the HRT group. Sexual activity was also higher among the
women taking tiboline, but the increase was not statistically significant"
- See
DHEA at Amazon.com.
-
Unhealthy lifestyle is associated with sexual dysfunction - Science
Daily, 7/6/11 - "A new study published in The
Journal of Sexual Medicine reveals that several unhealthy lifestyle factors,
such as weight problems, physical inactivity, high alcohol consumption,
tobacco smoking, and hard drugs are associated with sexual dysfunctions in
men. Additionally, an unhealthy lifestyle is more common in persons who are
sexually inactive ... Among those who had a sexual partner, risk of
experiencing sexual dysfunction was greater in men who lead unhealthy lives
by 71% in those with substantially increased waist circumference and more
than 800% in men using hard drugs. Women who used hashish had almost 3 times
increased risk of anorgasmia (difficulties or inability to reach climax
during sexual activity with a partner) compared to non-users"
-
Role of
androgens in women's sexual dysfunction - Menopause. 2010 Jun 8 -
"Significantly lower levels of two precursor hormones,
dehydroepiandrosterone sulfate and androstene-3beta,17beta-diol, were found in
women with sexual dysfunction ... Although the significance of the former awaits
further study, androgen deficiency in women with HSDD was not confirmed. Given
the unknown long-term effects of testosterone supplementation, women receiving
testosterone therapy should be informed that a deficit of testosterone activity
in women with HSDD has not been identified" - See
DHEA at Amazon.com.
-
Intravaginal dehydroepiandrosterone (Prasterone), the physiological and a
highly efficient treatment of vaginal atrophy - Menopause. 2009 May 8 -
"All three doses (0.25%, 0.5%, and 1.0%) of DHEA
ovules applied daily intravaginally induced a highly significant beneficial
change in the percentage of vaginal parabasal and superficial cells and pH
as well as in the most bothersome symptom at 2 weeks. At the standard
12-week time interval, 0.5% DHEA caused a 45.9 +/- 5.31 (P < 0.0001 vs
placebo) decrease in the percentage of parabasal cells, a 6.8 +/- 1.29% (P <
0.0001) increase in superficial cells, a 1.3 +/- 0.13 unit (P < 0.0001)
decrease in vaginal pH, and a 1.5 +/- 0.14 score unit (P < 0.0001) decrease
in the severity of the most bothersome symptom. Similar changes were seen on
vaginal secretions, color, epithelial surface thickness, and epithelial
integrity. Comparable effects were observed at the 0.25% and 1.0% DHEA doses
... Local Prasterone, through local androgen and estrogen formation, causes
a rapid and efficient reversal of all the symptoms and signs of vaginal
atrophy with no or minimal changes in serum steroids, which remain well
within the normal postmenopausal range. This approach avoids the fear of
systemic effects common to all presently available estrogen formulations and
adds a novel physiological androgenic component to therapy"
-
Serum
steroid levels during 12-week intravaginal dehydroepiandrosterone
administration - Menopause. 2009 May 8 - "The
present data show that local daily intravaginal DHEA administration at DHEA
doses of 3.25-13 mg was able to rapidly and efficiently achieve correction
of all the signs and symptoms of vaginal atrophy and improve sexual function
and caused no or minimal changes in serum sex steroid levels, which all
remain within the normal postmenopausal range, thus avoiding the risks of
all estrogen formulations"
-
Efficacy
and safety of low-dose regimens of conjugated estrogens cream administered
vaginally - Menopause. 2009 May 8 - "At week 12,
improvements in VMI with daily and twice-weekly use of low-dose CE cream
(27.9% and 25.8%, respectively) were significantly greater compared with
placebo (3.0% and 1.0%, respectively; P < 0.001). Improvements in vaginal pH
with daily and twice-weekly CE cream (-1.6 for both) were also significantly
greater relative to placebo (-0.4 and -0.3, respectively; P < 0.001). VMI
and vaginal pH responses were sustained through 52 weeks. Both CE cream
regimens significantly reduced most bothersome symptom scores compared with
placebo (P </= 0.001), including those for dyspareunia (P </= 0.01). There
was no report of endometrial hyperplasia or carcinoma. Adverse events
occurred with similar frequency among the active and placebo groups during
the double-blind phase"
- Menopause tied to sexual
dysfunction - MSNBC, 4/9/07 -
"Women who have particularly low levels of the
hormone DHEA during menopause may be more likely to have sexual dysfunction
... Women with relatively low blood levels of the hormone were 59 percent
more likely to report sexual problems than those with high levels"
- Sex Drive Need a
Tune-Up? - Dr. Weil, 9/25/06
-
DHEA Sulphate Levels May Signify Low Libido - Doctor's Guide, 6/18/04
-
Hormone Linked to Low Sex Drive in Women - HealthDay, 6/16/04 -
"this study has shown low testosterone bears no
relationship to low libido in women under 45 years of age. We found a strong
relationship between the low scores for desire, arousal and responsiveness
and low DHEA levels in women under 45" -
See
iHerb or
Vitacost
DHEA products.
-
Why Aging Women Need Testosterone - Life Extension Magazine, 4/04 -
"Controlled studies show that slightly increasing
testosterone levels in aging women restores sexual drive, arousal, and
frequency of sexual fantasies. In fact, low testosterone levels in women of
all ages seem to suppress libido and cause sexual dysfunction. Restoring
youthful testosterone in women has been shown to improve mood and well
being, and to provide many other health-enhancing benefits"
-
Exercise Improves Libido in Menopausal Women - Clinical Psychiatry News,
12/03
- Low-Dose DHEA
Increases Androgen, Estrogen Levels in Menopause - Medscape, 12/12/03 -
"Testosterone and dihydrotestosterone plasma levels,
and plasma E1 and E2 levels increased significantly and progressively in
both groups ... Cortisol F plasma levels
progressively decreased throughout the study. Both groups also experienced
significantly reduced LH and FSH plasma levels. GH and IGF-1 levels
significantly increased in both groups. Supplementation did not induce
changes in endometrial thickness ... These data support and confirm that
DHEA
must be considered a valid compound and drug for [hormone therapy] in
postmenopausal women and not just a 'dietary supplement" - See
iHerb or
Vitacost
DHEA products.
- Red Clover
Extract Helps Vaginal Dryness - WebMD, 7/9/03
- Oil [Zestra]
May Help Women With Arousal Problems - WebMD, 1/30/03 -
"Women with FSAD reported satisfaction with sexual arousal less than
one-third of the time while using the placebo oil, but 85% of the time with
Zestra" - See Zestra at
Zestra at drugstore.com
 .
-
Stress,
Cortisol and Health - Supplement Watch Newsletter, 10/02 -
"several lines of evidence have converged to
solidify the concept that stress makes us fat (because of
cortisol), thins our bones (because of cortisol), shrinks our brains
(because of cortisol), suppresses our immune system (because of cortisol),
saps our energy levels (because of cortisol), and kills our sex drive
(because of cortisol) ... Take a daily multivitamin/multi-mineral supplement
- because calcium,
magnesium, vitamin C and
B-complex vitamins are needed for a proper stress response ... Chief
among the supplements with documented cortisol-controlling effects are
Phosphatidylserine, Beta-sitosterol,
Magnolia bark, Theanine,
Epimedium, Ashwagandha and
Passionflower"
- Sexual Enhancement
Supplements (Including L-arginine, Yohimbe, and Epimedium (Horny Goat Weed))
review - ConsumerLab.com, 9/24/02 -
"In a four-week, double-blind study, 77 women with
decreased libido were given either the combination product (ArginMax)
or placebo. As expected, a high percentage of participants taking placebo
showed improvement. However, participants taking the product showed
statistically greater improvement such as increased reported sexual desire
level in 71% of participants given the treatment vs. 42% in the placebo
group" - See
Drugstore.com/GNC ArginMax products.
-
Possible treatment for female sexual dysfunction - Life Extension
Foundation, 9/01
- The Effects of
L-Arginine and Yohimbine on Sexual Arousal in Postmenopausal Women with FSAD
- University of Texas at Austin Dept. of Psychiatry
- Nutritional
Supplement [Arginmax] Reported to Improve Women's Sexual Function -
Medscape, 6/8/01
- Study: Supplement
Can Help Take the 'Dys' Out of Female Sexual Dysfunction, Researchers
Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 -
"ArginMax -- a dietary
cocktail consisting of ginseng, ginkgo, B vitamins, calcium, folic acid, and
other vitamins and minerals -- is being heralded as one component of a
lifestyle that improves sexual performance and helps prevent problems
associated with intimacy"
- Women and
Sex Drive - Life Enhancement Magazine, 12/99
Other News:
-
FDA Approves New
Libido-Boosting Drug for Premenopausal Women - Medscape, 6/21/19 -
"Bremelanotide is designed to be self-administered
subcutaneously with a disposable autoinjector at least 45 minutes before an
anticipated sexual encounter ... Users don't see the needle and it can be pushed
against the abdomen or thigh ... testing for both increase in desire and
reduction in distress, the hallmarks of HSDD ... We saw statistically
significant and clinically important improvements in both those parameters ...
The most common adverse events were nausea, flushing, and headache" - [NYT]
-
Too Few Women Treated for
Vulvovaginal Atrophy, Dyspareunia - Medscape, 10/31/17 -
"What we know clinically is that when sex is good, it
has about 20% added value, but when sex is bad, it is hugely, inordinately
powerful, draining a relationship 50% to 70% ... Bad sex does way more to
subvert an otherwise good relationship than good sex can support an average one.
Across the board, it's something we should treat"
-
New Options for Treating
Genital Atrophy - Medscape, 12/29/16 - "In November
2016, the US Food and Drug Administration (FDA) approved vaginal
dehydroepiandrosterone, also known as DHEA or prasterone and marketed as
Intrarosa™, for menopausal women experiencing pain with sexual intercourse due
to genital atrophy, a condition that is also known as genitourinary syndrome of
menopause.[1] In clinical trials, vaginal ovules of DHEA were found to be
effective in reducing symptoms of atrophy.[2] Vaginal discharge was the most
common adverse effect. After menopause, DHEA, which is produced largely by the
adrenals, is the main source of sex steroids. DHEA is enzymatically transformed
at the intracellular level into estrogen, which is then inactivated locally.
Accordingly, use of vaginal DHEA causes little, if any, rise in serum estradiol
levels"
-
Metabolic syndrome linked to sexual dysfunction in older women - Science
Daily, 7/12/16 - "women with metabolic syndrome reported
low sexual satisfaction, decreased desire, and diminished sexual activity. Waist
size, diabetes, and hypertension were additionally associated with decreased
sexual activity and elevated triglycerides were linked to lower desire"
-
Intravaginal DHEA Eases
Postmenopausal Vaginal Dryness, Pain - Medscape, 1/6/16 -
"unlike lubricants and moisturizers, it actually
corrects the problem ... Gynecologists saw 86% to 121% improvements in vaginal
secretions, lining thickness, and tissue color in the women who used DHEA" -
[Abstract]
-
Clarifying
Vaginal Atrophy's Impact on Sex and Relationships (CLOSER) survey: emotional and
physical impact of vaginal discomfort on North American postmenopausal women and
their partners - Menopause. 2013 Jun 3 -
"Approximately 30% of North American women and men cited vaginal discomfort as
the reason they ceased having sex altogether. North American women who used
local estrogen therapy to treat their vaginal discomfort reported less painful
sex (56%), more satisfying sex (41%), and improved sex life (29%). Most men
reported looking forward to having sex (57%) because of their partner's use of
local estrogen therapy"
-
Self-Administered Injection
Boosts Low Sex Drive in Women - Medscape, 5/30/13 -
"Subcutaneous injections of the melanocortin receptor agonist bremelanotide
effectively and safely treat premenopausal women suffering from female sexual
dysfunction ... Nausea was the most common side effect, but this occurred early
after the injection, was mild, and stopped with continued use. Other side
effects were flushing and headache"
-
Does vaginal
delivery affect postnatal coitus? - Int J Impot Res. 2013 May 16 -
"We concluded that vaginal delivery indeed may result in
loose vagina compared with cesarean delivery. However, it did not negatively
affect the postnatal sexual function. Therefore, women should be assured that
their sexual functions won't be affected by the types of delivery"
-
Hormone
levels and sexual motivation among young women - Science Daily, 4/25/13 -
"Estrogen was having a positive effect, but with a
two-day lag. Progesterone was having a persistent negative effect, both for
current day, day before, and two days earlier ... There's a common belief in the
medical literature that testosterone is the main regulator of women's libido ...
Doctors tend to believe that, though the evidence isn't that strong in humans.
In the natural cycles, we weren't finding effects of testosterone. It wasn't
significantly predicting outcomes"
-
FDA approves drug for painful sex in women - nbcnews.com, 2/26/13 -
"The U.S. Food and Drug Administration approved the
drug, Osphena, for a type of pain known as dyspareunia, which is a symptom of
vulvar and vaginal atrophy due to menopause ... The drug's label includes a
boxed warning, the most severe available, alerting patients to an increased risk
of strokes and deep vein thrombosis. Common side effects include hot flashes,
vaginal discharge, muscle spasms and excessive sweating"
-
Alprostadil Shows Efficacy
in Female Sexual Arousal Disorder - Medscape, 6/25/12 -
"female sexual arousal disorder (FSAD) ... satisfactory
sexual events (SSEs) ... Female Sexual Function Index (FSFI) ... Global
Assessment Questionnaire (GAQ) ... Female Sexual Distress Scale (FSDS) ... SSEs
improved with the alprostadil cream at all doses, with a significant improvement
(P = .0002) observed with the highest (900 mcg) dose (46.3%, 43.5%, and 53.9%
for 500 mcg, 700 mcg, and 900 mcg, respectively, compared with 33.1% in the
placebo group). The 900-mcg dose also resulted in significant improvements in
FSFI, GAQ, and FSDS scores compared with women receiving placebo"
-
Sexual
Satisfaction in Women Increases With Age - Science Daily, 1/3/12
-
'Female Viagra' May Treat Low Sexual Desire - WebMD, 5/18/10 -
"Flibanserin, an antidepressant-like drug, makes sex
more satisfying for some premenopausal women distressed over their low sexual
desire"
-
Towards
treating female sexual dysfunction: Research reveals secrets of female sexual
arousal - Science Daily, 4/13/10
-
Women: 4 Ways to Boost Your Sexual Life Expectancy - On Women - U.S. News,
3/10/10
-
Drug May Boost Women's Sexual Desire - WebMD, 11/19/09
-
Flibanserin Drug: Will 'Female Viagra' Boost Sex Drive? - Time Magazine,
11/18/09 - "Whether or not the FDA approves flibanserin
to treat women's libidos, the German company's trial results have reignited a
decade-long debate over the merit of the HSDD diagnosis — the most commonly
diagnosed female sexual dysfunction"
-
Drug Shown to Kindle Female
Sex Drive - Medscape, 11/16/09
-
Viagra
for women? Drug developed as antidepressant effective in treating low libido
- Science Daily, 11/16/09
-
Male
Impotence Drugs Show Promise For Treating Female Sexual Disorders, Study
Suggests - Science Daily, 4/17/09
-
Statin
study: Lower cholesterol, diminished joy of sex linked - USA Today, 3/5/09 -
"In the study, sexual pleasure sank along with LDL
levels ... Some studies have found that statins improve sexual function,
probably because the pills can improve blood flow to the genital area, Golomb
says. But she says the drugs also may reduce Coenzyme Q10, a nutrient that helps
cells convert oxygen, blood and glucose into energy. "Orgasm is a high-energy
activity," so losing the nutrient could weaken sexual pleasure, she says"
- See
ubiquinol products at Amazon.com.
-
Thumbs
Down For New Testosterone Patch To Boost Women's Sex Drive - Science Daily,
3/2/09 - "The published evidence so far is based on
highly selected women and only shows small improvements in sexual parameters and
large placebo responses"
-
Top
Cause Of Painful Sex Uncovered - Science Daily, 11/9/07
-
Is the metabolic syndrome a risk factor for female sexual dysfunction in
sexually active women? - Int J Impot Res. 2007 Sep 20 -
"In premenopausal women, the MS was an independent risk
factor for impaired sexual desire (P=0.03) with an age-adjusted odds ratio of
3.3 (95% confidence interval: 1.5-7.3). In premenopausal female sexual life, the
MS represents an independent role via its correlation to impaired desire"
-
Sex Boost From Late Hormone Therapy - WebMD, 9/24/07 -
"Hormone therapy did not help the women's memory ... The
level of sexual interest reported by women on hormone therapy increased 44%"
-
Testosterone Patch Benefits Women With Low Sexual Desire - Science Daily,
8/14/07 - "A total of 132 participants from the 2 trials
were interviewed after a 6-month treatment period regarding their experience
with the treatment. Results revealed a significant increase in frequency of
satisfying sexual activity and sexual desire based on women experiencing the
treatment as beneficial. Those women had an average increase in sexual activity
of 4.4 times per 4 weeks. In contrast, women who did not experience a benefit
had only a 0.5 increase in activity per 4 weeks"
-
Hypertension Tied to Sexual Dysfunction in Women - Clinical Psychiatry News,
11/06
-
Testosterone patch for the treatment of hypoactive sexual desire disorder in
naturally menopausal women: results from the INTIMATE NM1 Study - Menopause.
2006 Sep-Oct;13(5):770-9 - "Testosterone patch treatment
increased the frequency of satisfying sexual activity and sexual desire,
decreased personal distress, and was well tolerated in naturally menopausal
women with hypoactive sexual desire disorder"
-
How Effective is
Testosterone Replacement Therapy in Premenopausal Women with Severe Androgen
Deficiency? - Medscape, 10/2/06 -
"Beneficial effects of testosterone on mood (P = 0.029)
and sexual functioning (P = 0.044) were observed. There was also a marked
improvement in the general health and quality of life of patients receiving
testosterone, although changes in cognition were limited. Women receiving
testosterone had a 6% mean increase in total cholesterol levels when compared
with those receiving placebo"
-
Heart Drug for Female
Sexual Disorder? - WebMD, 7/24/06
-
Female Sexual Dysfunction Found in Almost 40% of Women - Doctor's Guide,
5/29/06 - "Despite the 40% overall prevalence of sexual
dysfunction in the study, only 13.4% of the women reported being dissatisfied
with their sex lives, while 25% said they were satisfied or neutral about their
sex life despite their symptoms of sexual dysfunction"
-
Blood Pressure and
Women's Sex Drive - WebMD, 5/19/06 -
"women with high blood pressure were twice as likely to
experience sexual dysfunction compared with their counterparts who had normal
blood pressure"
-
Testosterone Patch Helpful
for Women With Androgen Deficiency and Hypopituitarism - Medscape, 5/15/06 -
"Bone density increased in the hip and radius in the testosterone group by 0.9%
and 0.8% at 1 year, respectively ... Fat-free mass increased by 3.4% and 0.6% in
the testosterone vs placebo groups ... Testosterone increased muscle area in the
thigh ... Mood and sexual function were improved"
-
Do Testosterone Patches Help Women with Under-active Pituitary Glands? -
Doctor's Guide, 5/9/06 - "Loss of ovarian and/or
adrenal function can cause many women to experience hypopituitarism or
under-active pituitary glands, and therefore low levels of testosterone,
which is responsible for producing estrogen. This lack of testosterone can
be blamed for loss of sex drive, loss of muscle tone and decrease of
cognitive sharpness"
-
FDA-Approved Hormonal Therapies Needed to Effectively Treat Women With
Sexual Dysfunction - Doctor's Guide, 5/2/06
-
Surgery for Pelvic Disorders May Improve Sexual Function in Young Women
- Doctor's Guide, 10/25/05
-
Testosterone Therapy Improves Sexual Function In Post-menopausal Women -
Science Daily, 10/25/05 - "The addition of
testosterone to hormone therapy in women after menopause enhances their
sexual function. However, it may also reduce HDL cholesterol (the “good”
cholesterol) in women"
-
Topical Alprostadil Cream Improves Sexual Arousal in Women with Female
Sexual Arousal Disorder - Doctor's Guide, 10/20/05
-
Hormone Patch May Increase Sexual Desire in Menopausal Women - Doctor's
Guide, 7/26/05
-
Hormone Patch May Raise Women's Desire for Sex - WebMD, 7/25/05 -
"women wearing the testosterone patch reported
increased sexual desire and more frequent satisfying sexual experiences
compared with those wearing the fake patch"
-
Safety and Efficacy of a Testosterone Patch for the Treatment of Hypoactive
Sexual Desire Disorder in Surgically Menopausal Women: A Randomized,
Placebo-Controlled Trial - Archives of Internal Medicine, 7/25/05 -
"The 300-µg/d testosterone patch increased sexual desire and frequency of
satisfying sexual activity and was well tolerated in women who developed
hypoactive sexual desire disorder after surgical menopause"
-
Women's Sex Satisfaction Linked to Submission - WebMD, 7/21/05
-
No Link Found Between Low Androgen Levels and Low Sexual Function in Women
- Doctor's Guide, 7/7/05
-
Testosterone Level Doesn't Predict Low Libido - WebMD, 7/5/05 -
"assessing male sex hormone, or androgen, levels in
the blood is not an effective diagnostic tool for identifying low libido in
women"
-
New
Insight Into Potential Cause Of Sexual Dysfunction In Women - Science
Daily, 6/8/05
-
The Metabolic Syndrome: a Cause of Sexual Dysfunction in Women -
Medscape, 5/27/05 - "women with the
metabolic syndrome reported significantly
lower arousal, orgasm, and lubrication scores"
-
Testosterone Use in Menopause - Medscape, 5/6/05 -
"Her emotional and cognitive well-being, energy, and
overall quality of life have improved. Her libido was restored with perineal
testosterone, but the topical therapy was abandoned because of excessive
scalp hair loss"
- No testosterone patch! What
can I do? - MSNBC, 12/13/04
- Libido Drug for
Women Raises Hopes, Concerns - WebMD, 12/1/04
-
Testosterone Improves Women's Sex Lives - Science Daily, 11/23/04 -
"A testosterone supplement increased women's
interest and joy in sex and their satisfaction with the extent of their sex
life"
- Sex in
Menopause City - WebMD, 11/19/04
- Sexual
Problems Common Among Obese People - WebMD, 11/15/04
- Experts Publish
Sexual Dysfunction Guidelines - Psychiatric Times, 10/04
- New Gel May
Improve Women's Sexual Arousal - WebMD, 10/29/04
- Low Sexual
Desire Common in Women - WebMD, 10/21/04
- Testosterone
Patch: Women's Answer to Viagra? - WebMD, 10/20/04
-
Testosterone Patch Improves Sexual Function in Post-Menopausal Women -
Doctor's Guide, 10/20/04
-
Testosterone patch hailed as female Viagra - USA Today, 10/19/04 -
"Women on the testosterone patch had sex about four
times more than they usually did in two months compared to only one
additional session for women given a fake patch containing no hormone"
-
Testosterone Patch Could Help Women With Low Sexual Desire - Doctor's
Guide, 10/15/04
- Testosterone Patch
Can Improve Sexual Function in Women - Medscape, 10/11/04 -
"Results at 24 weeks showed that TTP therapy
significantly increased the frequency of "totally satisfying" sexual
episodes compared with placebo (high SHBG level group: 2.1 vs 0.5
episodes/month, P < .0001; ITT group: 1.9 vs 0.5 episodes/month, P < .0001)
and compared with baseline"
-
Female Testosterone Patch Significantly Improves Sexual Desire -
Doctor's Guide, 6/21/04 -
"Patients were an average of 49 years old ... The
testosterone patch group experienced a 51% increase in frequency of total
satisfying sexual activity, and a 49% increase in sexual desire versus
placebo"
- Birth Control,
HRT, and Sex Drive - WebMD, 6/9/04 -
"adding natural progesterone moderately reduced
estrogen's libido-stimulating effect, but adding MPA [medroxyprogesterone]
completely eliminated it ... aggression levels increased when they were on
the estrogen/MPA combination ... Oral delivery has more of an effect on
libido than transdermal or transvaginal delivery"
- Daily Apomorphine May
Be Useful for Women With Sexual Arousal Disorder - Medscape, 5/20/04
- Testosterone
Improves Sex for Some Women - WebMD, 5/5/04 -
"his study is the first large study of its kind to
demonstrate that small doses of testosterone improve sexual function in
these women"
-
Testosterone Patch Improved Postmenopausal Sexual Desire - Clinical
Psychiatry News Online, 1/04 -
"This is the first study to evaluate the efficacy of
a testosterone patch used in combination with an estrogen patch, rather than
oral estrogen, which is metabolized quite differently ... Women in the
testosterone group experienced an average increase of 75% in their sexual
desire scores over the course of the study"
-
Love Potions - Time Magazine, 1/19/04
- Viagra Improves
Sex for Some Women - WebMD, 1/7/04
- Depressed Women Have
More Sexual Dysfunction Than Depressed Men - Medscape, 11/7/03
-
Testosterone Patch Increases Sexual Desire in Surgically Menopausal Women
- Doctor's Guide, 10/23/03
- Testosterone Improves
Sexual Function in Women With HSDD - Medscape, 10/15/03 -
"After 24 weeks, the women in the
testosterone group showed a significant increase in the sexual desire
score of the PFSF compared with those in the placebo group ... Testosterone
therapy also resulted in a statistically significant change versus placebo
for each of the following PFSF domains: orgasm, sexual arousal, sexual
responsiveness, sexual self-image, and sexual concerns"
-
Searching For A Female Viagra - Time Magazine, 9/29/03 -
"Nearly 450 women who had lost their ovaries were
given either a
testosterone patch or a placebo. After six
months of treatment, the women on 300 mcg of testosterone a day reported an
81% increase in satisfying sexual activity and a 66% increase in sexual
desire"
-
Methyltestosterone/Oestrogen Therapy Improves Sexual Interest in Surgically
Menopausal Women - Doctor's Guide, 9/25/03 -
"Patients were randomised to receive either combined
oral esterified oestrogens and methyltestosterone (EEMT, Estratest Tablets,
Solvay Pharmaceuticals, Inc.) or oral esterified oestrogens alone (EE, two
Estratab Tablets, 0.625 mg each) for 8 weeks ... Overall, the researchers
observed significantly greater increases in SIQ total score, sexual interest
and desire subscale score, and responsiveness scores after 8 weeks of
treatment with EEMT as compared to EE therapy"
-
Testosterone Measurements in Postmenopausal Women Should Include Both Free
Testosterone and SHBG Levels - Doctor's Guide, 9/24/03 -
"When evaluating
testosterone levels in postmenopausal women, clinicians may need to
monitor both free testosterone and SHBG levels, because women who are
receiving testosterone therapy can have supraphysiologic serum total T
concentration, but normal free T concentrations ... We're already seeing a
testosterone patch for women going into phase II/phase III trials so I think
we're going to see this treatment to be a common treatment for women in the
next 5 years"
-
Testosterone Patches Treat Low Sexual Desire in Surgically Menopausal Women
- Doctor's Guide, 9/22/03
- Testosterone
Increases Libido in Women - WebMD, 6/26/03 -
"Half the women were treated for 16 weeks with the
low-dose oral estrogen-testosterone
combination drug Estratest HS ... By week eight, the testosterone-treated
patients had measurable improvements in testosterone levels that put them in
the upper normal range, and they reported improved interest in sex. They
also reported none of the common side effects of treatment with larger doses
of testosterone, such as excessive hair growth and acne" - See
Estratest at drugstore.com
 .
-
Valsartan Appears to Improve Sexual Function in Men and Women with
Hypertension - Doctor's Guide, 5/18/03 -
"Men and women being treated with the
angiotensin II receptor blocker valsartan for mild-to-moderate
hypertension appear to show improvements in sexual function and desire"
-
Transdermal Hormones Better than Oral for Improving Women's Sexual Quality
of Life - Doctor's Guide, 5/2/03 -
"At end point (20 weeks), 33% of 81 women on
CombiPatch reported improvement in Quality of Life scores compared to 17% of
84 on Prempro"
-
Sildenafil (Viagra) Effective in Reversing Serotonergic Reuptake
Inhibitor-Related Sexual Dysfunction in Women - Doctor's Guide, 5/1/03
- Female Sexual
Dysfunction Common - WebMD, 4/29/03
-
Women with Sexual Arousal Disorder Improve with Sildenafil - Doctor's
Guide, 4/28/03
-
Paper Defines Female Androgen Insufficiency - Clinical Psychiatry News,
2/03 -
"Androgens affect sexual desire, bone density,
muscle mass and strength, adipose tissue distribution, mood, energy, and
psychological well-being ... The free testosterone by dialysis is perhaps
the most accurate but also the most costly and is not performed by most labs
... Until better options are commercially available, the panel advised
clinicians to assess androgen production and androgen availability by
obtaining two out of the following three values: total
testosterone and sex hormone–binding globulin (SHBG), free testosterone
and SHBG, or free testosterone and total testosterone ... testosterone
values should be obtained in the morning hours and in the middle third of
the menstrual cycle in normally cycling premenopausal women ... The most
useful measurement of adrenal androgen production in women is
dehydroepiandrosterone sulfate (DHEAS), which is reliable and can be
used if a clinician suspects an adrenal cause for androgen insufficiency"
-
Sex Patch Gets Women In Mood - nbcsandiego.com, 2/7/03
- A
Female Counterpart to Viagra - NY Times, 1/27/02
-
Regular Periods Don't Rule Out Low Testosterone - Clinical Psychiatry
News, 1/03 -
"Physicians who see young women complaining of low
libido should consider that the problem could be low
testosterone even if the women have regular menstrual periods"
-
Viagra May Help Women On SSRIs - Clinical Psychiatry News, 12/02
-
Viagra Appears to Be Effective for Women Diagnosed With Sexual Arousal
Disorder - Clinical Psychiatry News, 12/02
-
Testosterone for 6 Weeks Helps Some Women With Sexual Dysfunction -
Clinical Psychiatry News, 12/02 -
"Women with sexual dysfunction whose free
testosterone levels are in the bottom third of the normal range or below
normal should be considered for a 6-week trial of androgen replacement
therapy ... A total of 25 patients in the series had a good response, 8 had
no response, 8 refused the therapy, and 9 were lost to follow-up"
-
Eros: Only FDA-Approved Female Sexual Device - Clinical Psychiatry News,
11/02
- Sexual Interest
Commonly Dips After 50 - WebMD, 10/7/02
-
Erotic Stimulation Plus Sildenafil Boosts Vaginal Vasocongestion -
Doctor's Guide, 8/9/02
-
Testosterone Deficiency & Depression, Does DHEA Raise the Levels of
Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 -
"As testosterone
replacement for women is becoming increasingly commonplace, women too
report not just restored libido, but also improved mood and greater energy,
less anxiety and more assertiveness"
- New Approaches to
Female Sexual Arousal Disorder - Medscape, 6/3/02
- New Drug
[alprostadil] Boosts Female Sex Response - WebMD, 5/28/02
-
Topical Alprostadil Appears Effective in Female Sexual Dysfunction -
Doctor's Guide, 5/28/02 - See
alprostadil.
-
Oestrogen-Androgen Replacement Significantly Benefits Postmenopausal Women
- Doctor's Guide, 4/26/02 -
"Compared with
oestrogen
alone, oestrogen-androgen significantly
increased total lean body mass and reduced the percentage fat for all body
parts ... There was a statistically significant increase in weight in the
oestrogen-androgen group (2.7 +/- 5.1 lb.) (1.22 +/- 2.31 kg.) compared with
the oestrogen only group ... In self-reporting questionnaires, women who
received oestrogen-androgen noted more improvement in
sexual functioning and quality of life than the women who received
oestrogen alone"
-
Proctor And Gamble To Test Patch To Restore Libido - Intelihealth,
2/11/02
- Helping Women Get
in the Mood - WebMD, 12/20/01
- Magnetic Resonance
Imaging, New Contrast Agent Help Identify Female Sexual Arousal -
Doctor's Guide, 6/6/01
- Unisex Hormones?,
Testosterone, DHEA May Help Both Sexes - WebMD, 5/4/01 -
"Low levels of male hormones probably account for
decreased muscularity, sexual interest, and bone density in menopausal women
... a 50 mg dose of DHEA each day enhanced sexual interest and satisfaction
in aging women, while promoting stronger bones and younger-looking skin"
- Better Patient/Doctor
Communication Needed To Improve Female Sexual Dysfunction Treatment -
Doctor's Guide, 5/1/01
- Hormone Replacement
Therapy Improves Sex Life Post-Menopause - Doctor's Guide, 5/1/01
- Wellbutrin (Bupropion
Hydrochloride) Shows Promise As Treatment For Low Female Sex Drive -
Doctor's Guide, 4/17/01 -
"almost one-third of the female subjects responded
to the treatment, with increases in the number of episodes of sexual
arousal, sexual fantasy, and interest in engaging in sexual activity"
- See Online Prescriptions. Also see
my Wellbutrin page.
-
Implant could help women with sexual dysfunction - CNN, 2/7/01
- Hormones Can Help
Some Love Lives -- but Can They Hurt Too? - WebMD, 10/31/00
- Experts Attempt
to Solve Female Sexual Dysfunction - WebMD, 9/17/00
-
Testosterone patch improves sexual function in women, study shows - CNN,
9/7/00
- Testosterone:
It's Not Just for Men Anymore - WebMD, 9/6/00
- High Blood
Pressure Harms Women's Sexual Function, Too - WebMD, 6/28/00
- Men have Viagra.
But what about women with a low libido? [Eros-CTD] - WebMD, 6/12/00
- Drug [bupropion]
Improves Women's Sexual Desire - WebMD, 6/9/00
- A New Focus on
Female Sexuality - WebMD, 6/9/00
- Viagra (Sildenafil)
Effective For Women With Sexual Dysfunction Related to Antidepressant
Therapy - Doctor's Guide, 5/8/00
- Topical alprostadil
produces significant clitoral hemodynamic changes - Doctor's Guide,
5/2/00
- Femprox Effective In
Treating Sexual Arousal Disorder In Women - Doctor's Guide, 12/2/99
- Testosterone Patch
Effective For Diminished Sexual Function In Surgically Menopausal Women
- Doctor's Guide, 6/15/99
- Viagra Appears To Have
Effect In Women - Doctor's Guide, 5/5/99
- Estrogen Plus Androgen
Therapy Improves Libido, Reduces Hot Flashes - Doctor's Guide, 8/8/97
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