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Anti-aging Research > Cordyceps Sinensis.
Cordyceps Sinensis
Specific Recommendations:
News & Research:
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Chinese Mushroom May Offer Energy Lift - WebMD, 4/20/04 -
"12 weeks of supplementation with CordyMax, a
dietary supplement made from the fermented Cordyceps mushroom, produced
slight but significant increases in several measures of exercise capacity,
metabolism, and endurance in healthy, sedentary adults"
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Medicinal Mushrooms Come Out of the Dark - Natural Foods Merchandiser,
7/03
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Mycological Medicine - Functional Foods & Nutraceuticals, 1/02
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ACSM Conference Unveils Performance Enhancers - Nutrition Science News,
9/01 -
"Researchers have shown that using the medicinal
mushroom Cordyceps sinensis (Cs-4 CordyMax) for six weeks results in peak
oxygen uptake and anaerobic threshold in older humans ... supplementation
with 4.5 g/day Cs-4 CordyMax ... Results showed that the supplement
prevented increased body weight during training, reduced submaximal heart
rate and blood lactate during exercise, and enhanced fat metabolism, thereby
sparing muscle glycogen expenditure during prolonged exercise compared to
placebo"
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What is your favorite supplement and why? - Nutrition Science News, 9/00
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"I think one of the more valuable supplements on the
market is the fungus Cordyceps sinensis. Its origins are in Tibet, and the
medicine has long been prized as one of the most valuable agents in the
Chinese materia medica, traditionally used for coughs, lung disorders and
stamina."
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Chinese Herbs Enhance Sexual Vitality - Nutrition Science News, 3/99
- A Brief
Introduction to Cordyceps Sinensis - Dr. Gilbert Ng -
"One of the reasons for aging is due to the
insufficient secretion of sexual hormones. Cordyceps Sinensis is, in this
regard, a hormone stimulator. Morever, the aging effect is to a large extent
attributed to the rise of active monoamine oxidize enzyme inside the body
and Cordyceps Sinensis can effectively inhibit the rising of such enzyme.
Thus, it is an anti-aging medicine which helps regenerate the organic
functioning of humans"
Abstracts:
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Cordycepin buffers
anisomycin-induced fear memory deficit by restoring hippocampal BDNF-
Biochem Biophys Res Commun 2023 May 3 - "The process of
memory consolidation involves the synthesis of new proteins, and interfering
with protein synthesis through anisomycin can impair memory. Memory deficits due
to aging and sleep disorders may also result from a reduction in protein
synthesis. Rescuing memory deficits caused by protein synthesis deficiency is
therefore an important issue that needs to be addressed ... We observed that
cordycepin was able to attenuate these deficits and restore BDNF levels in the
hippocampus. The behavioral effects of cordycepin were dependent on the BDNF/TrkB
pathway, as demonstrated by the use of ANA-12. Cordycepin had no significant
impact on locomotor activity, anxiety or fear memory. Our findings provide the
first evidence that cordycepin can prevent anisomycin-induced memory deficits by
regulating BDNF expression in the hippocampus" - See
cordycepin at Amazon.com.
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Polysaccharides from natural
Cordyceps sinensis attenuated dextran sodium sulfate-induced colitis in C57BL/6J
mice - Food Funct 2023 Jan 4 - "As potential
candidates for treating ulcerative colitis (UC), polysaccharides have been
attracting extensive interest in recent years. Cordyceps sinensis (C. sinensis)
is a kind of traditional Chinese edible food, and its polysaccharide fractions
have been found to be effective in regulating immunity and protecting the
kidneys ... Results showed that the polysaccharides significantly alleviated
colitis by increasing the colon length, alleviating colon tissue damage, and
inhibiting the activation of the NF-κB pathway. In addition, polysaccharides
reduced the contents of tumor necrosis factor-α (TNF-α) and interleukin-1β
(IL-1β) in the serum, increased the number of goblet cells, and improved the
expression of intestinal tight junction proteins (Occludin and Claudin-1). They
also evidently enhanced the formation of IgA-secretory cells and sIgA contents.
Furthermore, the polysaccharides modulated the gut microbiota by decreasing the
relative abundance of Bilophila and increasing the relative abundance of
Dehalobacterium, Coprococcus, Oscillospira, and Desulfovibrio, which is
accompanied by an increase in the short chain fatty acids' (SCFAs)
concentrations in cecal contents. These results suggested that C. sinensis
polysaccharides possessed promising intervening effects on experimental acute UC
in mice" - See cordyceps at Amazon.com.
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Cordycepin Inhibits the
Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic
Glycolysis - Evid Based Complement Alternat Med 2022 Nov 23 -
"Hepatocellular carcinoma (HCC) is one of the most
common malignant tumors in China, with a high incidence and mortality rate.
Glucose metabolism reprogramming is a major characteristic of tumor cells.
Increasing evidence indicates that aerobic glycolysis is associated with tumor
growth and insensitivity to chemotherapy. Cordycepin inhibits the growth of HCC
cells, but the mechanism is yet to be elucidated ... Taken together, these
findings revealed that cordycepin reduces the tumor energy supply and decreases
lactic acid production, thereby inhibiting the growth of HCC cells by regulating
the metabolic pathway of aerobic glycolysis. These findings might provide novel
insights into the mechanisms underlying cordycepin-mediated inhibition of tumor
growth as well as a new treatment for HCC"
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Cordycepin exhibits
anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway -
Biochem Biophys Res Commun 2022 Nov 9 - "Fatigue, a most
commonly sub-health condition, may cause people more susceptible to many
diseases. Cordycepin, a principal active ingredient from Cordyceps militaris,
exerts various pharmacological activities including anti-diabetes,
anti-inflammatory, immunomodulatory and antioxidant effects. However, the
anti-fatigue effect of cordycepin and specific mechanism remained unclear. This
study aimed to investigate the beneficial effect of cordycepin on physical
fatigue and elucidate the potential mechanism. 20 mg/kg, 40 mg/kg of cordycepin
and 500 mg/kg taurine were respectively treated to mice for 28 days before
weight-loaded swimming test. The results revealed that cordycepin significantly
prolonged the weight-loaded swimming time of mice. Meanwhile, cordycepin
decreased the levels of lactic acid, blood uric nitrogen, and malondialdehyde,
and increased the contents of superoxide dismutase, glutathione, nicotinamide
adenine dinucleotide phosphate, hepatic glycogen, muscle glycogen and ATP. The
metabolomic study by GC-MS showed that eight biomarkers were found in livers,
including L-lactic acid, L-asparagine, 3-phosphoglyceric acid, inosine, D-galactose,
L-tyrosine, glyceric acid and L-threonine. There were seven biomarkers in
gastrocnemius, including D-ribose-5-phosphate, acetic acid, propionic acid,
butyric acid, palmitic acid, oxaloacetic acid and citric acid. The results of
metabolomics indicated that cordycepin might relieve fatigue by regulating
energy metabolism and pentose phosphate pathway. Furthermore, we found
cordycepin significantly enhanced the protein levels of TIGAR, SIRT1, PGC-1α,
NRF1 and TFAM in gastrocnemius of weight-loaded swimming mice. Taken together,
the present study demonstrated that cordycepin possessed an anti-fatigue effect
via activating TIGAR/SIRT1/PGC-1α signaling pathway. Our study indicated that
cordycepin may be a potentially efficient candidate for fatigue"
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Cordyceps militaris
Carotenoids Protect Human Retinal Endothelial Cells against the Oxidative Injury
and Apoptosis Resulting from H2O2 - Evid Based Complement Alternat Med 2022
Sep 30 - "Vision loss is primarily caused by age-related
macular degeneration (AMD) due to oxidative retinal pigment epithelial (RPE)
cell injury. Carotenoid utilization is deemed a possible strategy for treating
AMD. Cordyceps militaris has advantages like immunomodulatory,
anti-inflammatory, and antioxidative characteristics ... The findings
demonstrated that CMCT safeguarded the ARPE-19 cells against the damage and
apoptosis caused by H2O2 and oxidative stress via Bcl-2 protein upregulation, as
well as the expression of Bax and cleaved caspase-3 protein. In addition, CMCT
treatment increased cell survival and restricted the generation of H2O2-induced
reactive oxygen species (ROS) and the protein expression of NADPH oxidase-1
(NOX1). Additionally, the CMCT treatment of H2O2-induced ARPE-19 cells
ameliorated high malondialdehyde (MDA) levels in oxidative stress-induced cells.
The catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH)
returned to standard levels, which were governed by the higher expression of
nuclear Nrf2 protein in the ARPE-19 cells. Moreover, this study showed that CMCT
safeguarded the ARPE-19 cells against the damage caused by oxidative stress via
its antioxidant activity and antiapoptotic functionality, suggesting the
potential therapeutic role of CMCT in AMD prevention and mitigation"
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Improvement in the Blood
Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris
- Evid Based Complement Alternat Med 2022 Mar 23 -
"Chronic kidney disease (CKD) is a critical public health issue with a huge
financial burden for both patients and society worldwide. Unfortunately, there
are currently no efficacious therapies to prevent or delay the progression of
end-stage renal disease (ESRD). Traditional Chinese medicine practices have
shown that Cordyceps militaris (C. militaris) mycelia have a variety of
pharmacologically useful properties, including antitumor, immunomodulation, and
hepatoprotection. However, the effect of mycelial C. militaris on CKD remains
unclear ... nvestigated the effects of C. militaris mycelia on mice with CKD
using four types of media: HKS, HKS with vitamin A (HKS + A), CM, and CM with
vitamin A (CM + A) ... The results at day 10 revealed that the levels of blood
urea nitrogen (BUN) were significantly lower in the HKS (41%), HKS + A (41%),
and CM + A (34%) groups compared with those in the corresponding control groups
(nephrectomic mice). The level of serum creatinine in the HKS + A group
decreased by 35% at day 10, whereas the levels in the HKS and CM + A groups
decreased only by 14% and 13%, respectively, on day 30. Taken together, this is
the first report using four new media (HKS, HKS + A, CM, and CM + A medium) for
C. militaris mycelia. Each medium of mycelial C. militaris on CKD exhibits
specific effect on BUN, serum creatinine, body weight, total protein, and uric
acid" - See Cordyceps at Amazon.com.
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Cordycepin, a major
bioactive component of Cordyceps militaris, ameliorates diabetes-induced
testicular damage through the Sirt1/Foxo3a pathway - Andrologia 2021 Nov 22
- "Diabetes-induced male dysfunction is considered as a
worldwide challenge, and testicular damage mainly caused by oxidative stress is
its most common manifestation. Cordycepin, a natural antioxidant, has been used
in the treatment of diabetic complications ... These findings indicated that
cordycepin could improve hyperglycaemia-induced testicular damage by regulating
downstream antioxidant enzymes activity through the SIRT1/Foxo3a signalling
pathway" - See cordyceps at Amazon.com.
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Cordyceps militaris Fruit
Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated
Prostate Hypertrophy - Nutrients 2020 Dec 26 -
"late-onset hypogonadism (LOH) ... The fruit bodies of fungi of the genus
Cordyceps have been regarded as folk medicine or health food with tonic and
antifatigue effects. The extract from the fruit body of Cordyceps militaris
parasitizing Samia cynthia ricini (CM) was evaluated as a novel-candidate
natural product for ameliorating male andropause symptoms. To explore the
effects of CM on LOH and BPH, CM was applied to rat models and cultured
testicular cells and prostate cells. The concentrations of androgens in the
serum and culture media were determined by ELISA. Expression of steroidogenic
enzymes and androgen-related genes was evaluated by qPCR, and prostatic cell
proliferation was assessed with the cell-viability assay. CM maintained the
serum levels of testosterone and DHT, but inhibited testosterone-induced
prostate hypertrophy. CM also increased the secretion of testosterone and DHT by
primary testicular cells, with no changes in the mRNA expression of
steroidogenic enzymes, but decreased the growth of prostatic cell lines. Our
data suggest that CM could improve both LOH and BPH in males."
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Cordycepin reduces weight
through regulating gut microbiota in high-fat diet-induced obese rats -
Lipids Health Dis. 2018 Dec 6 - "Our study suggests that cordycepin can reduce
body weight and microbiome done by cordycepin seems be a result among its
mechanisms of obesity reduction"
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Cordyceps militaris
Improves Tolerance to High-Intensity Exercise After Acute and Chronic
Supplementation - J Diet Suppl. 2016 Jul 13 - "time
to exhaustion (TTE) ... ventilatory threshold (VT) ... Relative peak power
output (RPP) ... average power output (AvgP) ... Subjects consumed 4 g·d-1
mushroom blend (MR) or maltodextrin (PL) for 1 week. Ten volunteers supplemented
for an additional 2 weeks ... One week of supplementation elicited no
significant time × treatment interaction for VO2max (p = 0.364), VT (p = 0.514),
TTE (p = 0.540), RPP (p = 0.134), AvgP (p = 0.398), or %drop (p = 0.823). After
3 weeks, VO2max significantly improved (p = 0.042) in MR (+4.8 ml·kg-1·min-1),
but not PL (+0.9 ml·kg-1·min-1). Analysis of 95% confidence intervals revealed
significant improvements in TTE after 1- (+28.1 s) and 3 weeks (+69.8 s) in MR,
but not PL, with additional improvements in VO2max (+4.8 ml·kg-1·min-1) and VT
(+0.7 l·min-1) after 3 weeks" - [Nutra
USA]
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Antidepressant-like effects of cordycepin in a mice model of chronic
unpredictable mild stress - Evid Based Complement Alternat Med.
2014;2014:438506 - "This study is attempted to
investigate whether cordycepin (COR) possesses beneficial effects on chronic
unpredictable mild stress- (CUMS-) induced behavioral deficits
(depression-like behaviors) and explore the possible mechanisms ... COR
remarkably improved depression-like behavior in CUMS mice and its
antidepressant activity is mediated, at least in part, by the upregulating
BDNF and downregulating 5-HT2AR levels and inflammation in hippocampus"
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Antidepressant-Like Effect of Cordyceps sinensis in the Mouse Tail
Suspension Test - Biol Pharm Bull. 2007 Sep;30(9):1758-62 -
"Cordyceps sinensis (CS) has been known as a
component of traditional medicines that elicit various biological effects
such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it
has been well-established that fatigue is closely related to depression, we
used the tail suspension test (TST) in mice to examine the
antidepressant-like effects of hot water extract (HWCS) and supercritical
fluid extract (SCCS) of CS ... these results suggest that SCCS may elicit an
antidepressant-like effect by affecting the adrenergic and dopaminergic
systems, but not by affecting the serotonergic system"
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Anti-oxidation activity of different types of natural Cordyceps sinensis and
cultured Cordyceps mycelia - Phytomedicine 2001 May;8(3):207-12 -
"Cordyceps, in general, possesses a strong
anti-oxidation activity in all assays tested"
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