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Anti-aging Research > Cruciferous Vegetables
Cruciferous Vegetables
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Uncovered: Key to how exercise protects against consequences of aging -
Science Daily, 12/16/21 - "Exercise-induced ROS
drives adaptive responses that are integral to the health-promoting effects
of exercise ... an enzyme called NOX-4 is essential for exercise-induced ROS
and the adaptive responses that drive metabolic health ... that NOX4 is
increased in skeletal muscle after exercise and that this then leads to
increased ROS which elicits adaptive responses that protect mice from the
development of insulin resistance, which otherwise occurs with ageing or
diet induced-obesity ... One of these compounds is found naturally, for
instance, in cruciferous vegetables, such as broccoli or cauliflower, though
the amount needed for anti-ageing effects might be more than many would be
willing to consume" - See
cruciferous vegetables supplements at Amazon.com.
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Broccoli sprout compound may restore brain chemistry imbalance linked to
schizophrenia - Science Daily, 5/8/19 - "It's
possible that future studies could show sulforaphane to be a safe supplement
to give people at risk of developing schizophrenia as a way to prevent,
delay or blunt the onset of symptoms ... The researchers used MRS again to
monitor three brain regions for glutathione levels in the healthy volunteers
before and after taking sulforaphane. They found that after seven days,
there was about a 30% increase in average glutathione levels in the
subjects' brains. For example, in the hippocampus, glutathione levels rose
an average of 0.27 millimolar from a baseline of 1.1 millimolar after seven
days of taking sulforaphane" - See
sulforaphane at Amazon.com
 .
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Could broccoli be a secret weapon against diabetes? - Science Daily,
6/14/17 - "The researchers constructed a signature
for type 2 diabetes based on 50 genes, then used publically available
expression datasets to screen 3,852 compounds for drugs that potentially
reverse disease. The most promising chemical -- sulforaphane, a naturally
occurring compound found in cruciferous vegetables -- tamped down glucose
production by liver cells growing in culture, and shifted liver gene
expression away from a diseased state in diabetic rats ... When the
researchers gave concentrated broccoli sprout extracts to 97 human type 2
diabetes patients in a 12-week randomized placebo-controlled trial, obese
participants who entered the study with dysregulated disease demonstrated
significantly decreased fasting blood glucose levels compared to controls"
- See sulforaphane at Amazon.com.
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Dietary anti-cancer compound may work by influence on cellular genetics
- Science Daily, 3/16/17 - "They found that
sulforaphane, a dietary compound from broccoli that's known to help prevent
prostate cancer, may work through its influence on long, non-coding RNAs ...
Scientists now believe that when these lncRNAs are dysregulated they can
contribute to multiple disease processes, including cancer ... Unlike many
chemotherapeutic drugs that affect healthy cells as well as malignant ones
and can cause undesired side effects, the control of lncRNAs may offer a new
way to specifically prevent or slow the progression of malignant cells ...
In particular, this research showed that one lncRNA, called LINC01116, is
upregulated in a human cell line of prostate cancer, but can be decreased by
treatment with sulforaphane"
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Sulforaphane, a phytochemical in broccoli sprouts, ameliorates obesity -
Science Daily, 3/7/17 - "the mice fed with
sulforaphane exhibited the weight gain rate 15% lower than that of the mice
fed without sulforaphane, 20% visceral fat reduction, and reduction of
augmentation of their hepatic steatosis and blood glucose level" -
See Jarrow Formulas BroccoMax at Amazon.com.
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Broccoli sprout extract may protect against oral cancer recurrence - Science
Daily, 6/23/16 - "With head and neck cancer, we often clear patients of cancer
only to see it come back with deadly consequences a few years later ...
Cruciferous vegetables, such as broccoli, cabbage and garden cress, have a high
concentration of the naturally occurring molecular compound sulforaphane, which
previously has been shown to protect people against environmental carcinogens
... 10 healthy volunteers drank or swished fruit juice mixed with broccoli
sprout extract for several days. The volunteers had no significant problems
tolerating the extract and the lining of their mouths showed that the same
protective genetic pathway activated in the laboratory cell tests was activated
in their mouths, meaning that the sulforaphane was absorbed and directed to
at-risk tissue ... to see how the extract performed in mice predisposed to head
and neck cancer. The mice who received the sulforaphane developed far fewer
tumors than their counterparts who did not receive the extract"
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Broccoli may offer protection against liver cancer, study shows -
Science Daily, 3/3/16 - "including broccoli in the
diet may also protect against liver cancer, as well as aid in countering the
development of fatty liver or nonalcoholic fatty liver disease (NAFLD) which
can cause malfunction of the liver and lead to hepatocellular carcinoma
(HCC), a liver cancer with a high mortality rate ... in mice on the
Westernized diet both the number of cancer nodules and the size of the
cancer nodules increased in the liver. But when broccoli was added to the
diet, the number of nodules decreased ... There are actually two ways of
getting fatty liver; one, by eating a high-fat, high-sugar diet and the
other by drinking too much alcohol ... Broccoli stopped too much uptake of
fat into the liver by decreasing the uptake and increasing the output of
lipid from the liver"
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Broccoli sprout extract promising for head and neck cancer prevention -
Science Daily, 4/19/15 - "People who are cured of
head and neck cancer are still at very high risk for a second cancer in
their mouth or throat, and, unfortunately, these second cancers are commonly
fatal ... cruciferous vegetables that have a high concentration of
sulforaphane ... his team gave sulforaphane to mice predisposed to oral
cancer and found that it significantly reduced the incidence and number of
tumors" - See
sulforaphane at Amazon.com.
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Beyond prevention: Sulforaphane may find possible use for cancer therapy
- Science Daily, 1/12/14 - "The new study identified
a particular enzyme in prostate cancer cells, SUV39H1, that is affected by
exposure to sulforaphane ... sulforaphane has shown toxicity to a number of
human cancer cell lines, including prostate, breast, ovarian, colon and
pancreatic cancer, and in animal studies it decreased metastases of prostate
cancer"
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Broccoli Compound Shows Promise for Autism Symptoms in Small Study -
WebMD, 10/13/14 - "recruited 44 boys and young men,
aged 13 to 27, with moderate to severe autism. They were randomly assigned
to take either sulforaphane capsules or identical-looking placebo capsules
every day for 18 weeks ... Based on parents' reports, many of the boys
taking the extract started showing improvements in irritability, repetitive
behaviors, hyperactivity and communication by the fourth week ... 46 percent
of the sulforaphane group were showing improved social interactions by week
18. Another 42 percent were faring better with verbal communication, and 54
percent were reining in various "aberrant" behaviors ... None of those
taking the placebo had improvements in social interactions or verbal
communications" - [Science
Daily] [Abstract]
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Top 4 Foods for Thicker, Shinier Hair - ABC News, 4/29/14 -
"The brassicas (cabbage, Brussels sprouts, broccoli,
kale) are packed full of healthy nutrients and have been shown to help
decrease the risk of heart disease and cancer. They are also rich in
phosphatidic acid, little fatty acid messengers involved in cell creation
and survival. A study in the Journal of Investigative Dermatology found that
phosphatidic acid also promotes hair growth due to its growth-promoting
effects on the cells in our hair follicles"
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Broccoli to fight skin cancer? - Science Daily, 9/4/13 -
"Dr. Dickinson's research currently focuses on how
sulforaphane -- a naturally occurring compound in broccoli with established
chemopreventive properties -- could possibly be used to help patients reduce
their risk for skin cancer ... Sulforaphane may be an excellent candidate
for use in the prevention of skin cancer caused by exposure to ultraviolet
rays ... sulforaphane is a highly adaptable, highly effective agent when it
comes to inhibiting cancer-causing pathways (such as the AP-1 protein),
while activating chemoprotective genes (such as the Nrf2 gene) ... Her pilot
study in collaboration with Johns Hopkins University will test a topical
broccoli sprout solution on the skin a group of patients to see if the
compound is effective in the context of solar simulated light ...
Sulforaphane is the kind of compound that has so many incredible theoretical
applications if the dosage is measured properly ... We already know that it
is very effective in blocking sunburns, and we have seen cases where it can
induce protective enzymes in the skin" - See
sulforaphane at Amazon.com and my macaroni
and cheese recipe which contains broccoli.
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Broccoli could be key in the fight against osteoarthritis - Science
Daily, 8/27/13 - "sulforaphane slows down the
destruction of cartilage in joints associated with painful and often
debilitating osteoarthritis. The researchers found that mice fed a diet rich
in the compound had significantly less cartilage damage and osteoarthritis
than those that were not ... The study, which also examined human cartilage
cells and cow cartilage tissue, was funded by medical research charity
Arthritis Research UK ... Sulforaphane is released when eating cruciferous
vegetables such as Brussels sprouts and cabbage, but particularly broccoli
... sulforaphane blocks the enzymes that cause joint destruction by stopping
a key molecule known to cause inflammation"
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Food Supplement Linked
to Lower PSA in Prostate Cancer - Medscape, 6/10/13 -
"A commercially available food supplement that
contains pomegranate, broccoli, green tea, and turmeric significantly lowers
prostate-specific antigen (PSA) levels ... made headlines around the world
and caused the polyphenol-rich supplement, known as Pomi-T (nature Medical
Products), to sell out within hours ... to receive the supplement 3 times a
day for 6 months or placebo ... At 6-month follow-up, the median increase in
PSA was 63.8% lower in the supplement groups than in the placebo group
(14.7% vs 78.5; P =.0008). In addition, PSA levels were stable or lower than
baseline more often in the supplement group (46% vs 14%"
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Vegetable compound could become ingredient to treating leukemia -
Science Daily, 12/12/12 - "A concentrated form of a
compound called sulforaphane found in broccoli and other cruciferous
vegetables has been shown to reduce the number of acute lymphoblastic
leukemia cells in the lab setting ... performed this work while a clinical
fellow in the Texas Children's Cancer and Hematology Centers, incubated
human-derived leukemic cell lines and primary lymphoblasts from pediatric
patients with the compound. The cancer cells died while the healthy cells
obtained from healthy donors were unaffected. Studies tested in pre-clinical
mouse models showed similar results" - See
sulforaphane at Amazon.com.
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Eating cruciferous vegetables may improve breast cancer survival -
Science Daily, 4/3/12 - "a prospective study of
4,886 Chinese breast cancer survivors who were diagnosed with stage 1 to
stage 4 breast cancer from 2002 to 2006 ... Women who were in the highest
quartiles of intake of vegetables per day had a 62 percent reduced risk of
total mortality, 62 percent reduced risk of breast cancer mortality, and 35
percent reduced risk of breast cancer recurrence ... cruciferous vegetable
consumption habits differ between China and the United States and suggested
this fact be considered when generalizing these results to U.S. breast
cancer survivors ... Commonly consumed cruciferous vegetables in China
include turnips, Chinese cabbage/bok choy and greens, while broccoli and
Brussels sprouts are the more commonly consumed cruciferous vegetables in
the United States and other Western countries ... Cruciferous vegetables
contain phytochemicals known as isothiocyanates and indoles which appear to
have a protective effect against some types of cancer"
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Eat
your broccoli: Another mechanism discovered by which sulforaphane prevents
cancer - Science Daily, 2/28/12 - "it provides
not just one, but two ways to prevent cancer through the complex mechanism
of epigenetics ... Epigenetics, an increasing focus of research around the
world, refers not just to our genetic code, but also to the way that diet,
toxins and other forces can change which genes get activated, or
"expressed." This can play a powerful role in everything from cancer to
heart disease and other health issues ... HDAC inhibitors, such as
sulforaphane, can help restore proper balance and prevent the development of
cancer. This is one of the most promising areas of much cancer research. But
the new OSU studies have found a second epigenetic mechanism, DNA
methylation, which plays a similar role" - See
sulforaphane at Amazon.com.
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More
evidence that spicing up broccoli boosts its cancer-fighting power -
Science Daily, 9/13/11
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Broccoli extract can ‘target’ cancer cells: Study - Nutra USA, 6/15/11 -
"The research, published in Molecular Nutrition and
Food Research, reports for the first time that sulforaphane – one of the
primary phytochemicals in broccoli and other cruciferous vegetables – is
able to selectively target and kill cancer cells, while leaving normal cells
healthy and unaffected ... Here we show for the first time that sulforaphane
selectively targets benign hyperplasia cells and cancerous prostate cells
while leaving the normal prostate cells unaffected"
- [Abstract]
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Study confirms safety, cancer-targeting ability of nutrient in broccoli,
other vegetables, researchers say - Science Daily, 6/9/11 -
"Sulforaphane, one of the primary phytochemicals in
broccoli and other cruciferous vegetables that helps them prevent cancer,
has been shown for the first time to selectively target and kill cancer
cells while leaving normal prostate cells healthy and unaffected ... Here we
show for the first time that sulforaphane selectively targets benign
hyperplasia cells and cancerous prostate cells while leaving the normal
prostate cells unaffected" - See
sulforaphane at Amazon.com.
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Sprouts? Supplements? Team them up to boost broccoli's cancer-fighting power
- Science Daily, 1/27/11 - "To get broccoli's
benefits, though, the enzyme myrosinase has to be present; if it's not
there, sulforaphane, broccoli's cancer-preventive and anti-inflammatory
component, doesn't form ... There was almost a twofold increase in
sulforaphane absorption when sprouts and powder were eaten together. It
changed the way the subjects metabolized the powder. We saw plasma and urine
metabolites much earlier and at much higher levels than when either was
eaten alone ... Steaming broccoli for two to four minutes is the perfect way
to protect both the enzyme and the vegetable's nutrients"
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Discovery of a biochemical basis for broccoli's cancer-fighting ability
- Science Daily, 1/26/11
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Eating broccoli could guard against arthritis - Science Daily, 9/15/10 -
"a compound in broccoli called sulforaphane blocks
the enzymes that cause joint destruction in osteoarthritis -- the most
common form of arthritis" - See
sulforaphane at Amazon.com.
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Anti-cancer effects of broccoli ingredient explained - Science Daily,
7/12/10 - "sulforaphane, a chemical found in
broccoli, interacts with cells lacking a gene called PTEN to reduce the
chances of prostate cancer developing"
- See
sulforaphane at Amazon.com.
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Plant extract may be effective against inflammatory bowel disease -
Science Daily, 7/7/10 - "PEITC is found in the
Brassica genus of plants, which includes cabbage, cauliflower, watercress
and broccoli ... it not only alleviates several clinical signs of ulcerative
colitis -- for example, it attenuates the damage that occurs in the colon
tissues and colon epithelium, as well as the clinical signs like diarrhea
and blood in stool. The weight loss is a major sign in colitis and that was
alleviated, too"
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New
combination effective against pancreatic cancer: Substance in broccoli
supports cancer therapy, study finds - Science Daily, 6/15/10 -
"Sorafenib is used for advanced liver and kidney
cancer and also appears to be effective against cancer stem cells in
pancreatic cancer ... It inhibits resistant tumor stem cells and is also
especially effective in combination with sulforaphane, an organic compound
found in broccoli ... vegetables from the cruciferous family such as
broccoli and cauliflower possess a high content of sulforaphane, an
anti-cancer compound. The experiments show that sulforaphane prevents the
activation of the NF-kB pathway by sorafenib. The combination treatment
reinforces the effect of sorafenib without causing additional side effects"
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Broccoli component limits breast cancer stem cells, study finds -
Science Daily, 5/4/10 - "In the current study,
researchers took mice with breast cancer and injected varying concentrations
of sulforaphane from the broccoli extract. Researchers then used several
established methods to assess the number of cancer stem cells in the tumors.
These measures showed a marked decrease in the cancer stem cell population
after treatment with sulforaphane, with little effect on the normal cells.
Further, cancer cells from mice treated with sulforaphane were unable to
generate new tumors. The researchers then tested sulforaphane on human
breast cancer cell cultures in the lab, finding similar decreases in the
cancer stem cells"
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Broccoli-extract may protect skin from harmful UV - Nutra USA, 4/9/10 -
"Hairless mice developed 25 per cent fewer skin
tumours following exposure to UV radiation and fed a the broccoli extract
for 13 weeks, compared with mice receiving a standard protective agent ...
In addition, the tumours the broccoli-fed mice did develop were 70 per cent
smaller" - [Abstract]
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Antioxidant found in vegetables has implications for treating cystic
fibrosis - 11/20/09 - "a dietary antioxidant
found in such vegetables as broccoli and cauliflower protects cells from
damage caused by chemicals generated during the body's inflammatory response
to infection and injury. The finding has implications for such
inflammation-based disorders as cystic fibrosis (CF), diabetes, heart
disease, and neurodegeneration ... the antioxidant thiocyanate normally
existing in the body protects lung cells from injuries caused by
accumulations of hydrogen peroxide and hypochlorite, the active ingredient
in household bleach. These potentially harmful chemicals are made by the
body as a reaction to infection and injury. In addition, thiocyanate also
protects cells from hypochlorite produced in reactions involving MPO, an
enzyme released from germ-fighting white blood cells during inflammation"
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Broccoli extract’s heart health benefits pinpointed? - Nutra USA, 9/7/09
- "Researchers from Imperial College London (ICL)
report that sulforaphane, a compound most widely associated with broccoli,
may activate a protein called Nrf2 in arteries ... the natural compound
sulforaphane reduced inflammation at the high-risk areas by 'switching on'
Nrf2 ... Atherosclerosis, known as hardening or furring of the arteries is a
key risk factor for cardiovascular disease, the cause of over 50 per cent of
deaths in Europe and the US ... When these cells were exposed to
sulforaphane, a re-activation of Nrf2 in the disease-prone regions of the
artery was observed. This indicated that the cells’ ability to protect
themselves from becoming inflamed was restored" - [Abstract]
- See
sulforaphane at Amazon.com.
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Naturally Occurring Compounds Selectively Deplete Mutant P53 In Tumor Cells
- Science Daily, 4/20/09 - "This study demonstrates
for the first time that phenethyl isothiocyante (PEITC), a
naturally-occurring compound, can selectively deplete mutant p53. The
authors also made an intriguing observation that the depletion of mutant p53
in human cancer cells is accompanied by restoration of the wild type p53.
PEITC is a member of the isothiocyanate family compounds found in
cruciferous vegetables, such as watercress, broccoli and cabbage. PEITC has
been shown to have cancer preventive activity"
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Broccoli May Help Protect Against Respiratory Conditions Like Asthma -
Science Daily, 3/2/09 - "a naturally occurring
compound found in broccoli and other cruciferous vegetables may help protect
against respiratory inflammation that causes conditions like asthma,
allergic rhinitis and chronic obstructive pulmonary disease ...
sulforaphane, a chemical in broccoli, triggers an increase of antioxidant
enzymes in the human airway that offers protection against the onslaught of
free radicals that we breathe in every day in polluted air, pollen, diesel
exhaust and tobacco smoke" - See
sulforaphane at Amazon.com.
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Broccoli And Cabbage-based Drug Could Inhibit Melanoma - Science Daily,
3/1/09 - "We have developed drugs from naturally
occurring compounds that can inhibit the growth of tumors in mice by 50 to
60 percent with a very low dose ... Robertson and his colleagues previously
showed the therapeutic potential of targeting the Akt3 protein in inhibiting
the development of melanoma. The search for a drug to block the protein led
them to a class of compounds called isothiocyanates ... These naturally
occurring chemicals found in cruciferous vegetables are known to have
certain cancer-fighting properties ... Selenium deficiency is common in
cancer patients ... the selenium-enhanced compounds significantly reduced
the production of Akt3 protein and shut down its signaling network"
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How
Certain Vegetables Combat Cancer - Science Daily, 12/23/08 -
"Breast cancer, the second leading cause of cancer
deaths in women, can be protected against by eating cruciferous vegetables
such as cabbage and near relatives of cabbage such as broccoli and
cauliflower ... Our paper focuses on the anti-cancer activity of one of
these compounds, called sulforaphane, or SFN ... SFN inhibits the
proliferation of human tumor cells by a mechanism similar to the way that
the anticancer drugs taxol and vincristine inhibit cell division during
mitosis ... SFN, like the more powerful anticancer agents, interferes with
microtubule functioning during mitosis in a similar manner to the more
powerful anticancer drugs ... SFN may be an effective cancer preventive
agent because it inhibits the proliferation and kills precancerous cells"
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Broccoli May Help Smokers' Lungs - WebMD, 11/18/08 -
"asked 948 lung cancer patients and 1,743 people
without lung cancer about their smoking history and consumption of fruits,
cruciferous vegetables, and other vegetables ... Among smokers -- and
especially among former smokers -- higher intake of cruciferous vegetables
was linked to lower risk of lung cancer"
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Unpopular veggies vital for cancer protection: Study - Nutra USA,
10/7/08 - "Significant inhibition of all the cancer
cell lines tested – stomach, lung, breast, kidney, skin, pancreas, prostate,
and brain – was observed for all the extracts from cruciferous vegetables,
such as broccoli, kale, Brussels sprouts, and curly cabbage, and vegetables
of the genus Allium, such as garlic ... These chemopreventive effects are
likely related to the formation of organosulfur compounds following
mechanical disruption of these vegetables, namely isothiocyanates from
cruciferous and a series of allyl sulfur molecules from Allium vegetables"
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COPD? Eat Your Veggies - Science Daily, 9/12/08 -
"Sulforapane has been shown to be able to restore
antioxidant gene expression in human epithelial tissue in which DJ-1 has
been reduced. Isothicyanate compounds such as that found in broccoli inhibit
KEAP1, and thus prevent it from degrading NRF2"
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Broccoli Could Reverse The Heart Damaging Effects Of Diabetes - Science
Daily, 8/26/08 - "Our study suggests that compounds
such as Sulforaphane from broccoli may help counter processes linked to the
development of vascular disease in diabetes"
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Broccoli can reverse diabetic heart damage, say researchers - Nutra USA,
8/8/08 - "Our study suggests that compounds such as
Sulforaphane from broccoli may help counter processes linked to the
development of vascular disease in diabetes ... Published in the journal
Diabetes Care, the epidemiological study of 71,346 female nurses found for
every additional serving of green leafy vegetables, the risk of developing
diabetes may be reduced by almost 10 per cent" - [Abstract]
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Activation of NF-E2-related factor-2 reverses biochemical dysfunction of
endothelial cells induced by hyperglycemia linked to vascular disease -
Diabetes. 2008 Aug 4 - "Sulforaphane (SFN) is an
activator of transcription factor NF-E2-related factor-2 (nrf2) that
regulates gene expression through the promoter antioxidant response element
(ARE). Nrf2 regulates the transcription of a battery of protective and
metabolic enzymes ... We conclude that activation of nrf2 may prevent
biochemical dysfunction and related functional responses of endothelial
cells induced by hyperglycemia in which increased expression of
transketolase has a pivotal role" - [Nutra
USA]
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Broccoli May Cut Prostate Cancer Risk - WebMD, 7/1/08 - [Science
Daily] - "men who regularly ate broccoli showed
more changes in gene expression suggestive of a reduced risk of cancer"
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Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 -
"Foods rich in plant chemicals called
isothiocyanates and quercetin appeared to offer the best protection against
lung cancer ... Isothiocyanates are found in cruciferous vegetables such as
broccoli, cabbage, cauliflower, brussels sprouts, and turnips"
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Could
foods prevent ovarian cancer? - MSNBC, 3/14/08 -
"Kaempferol — a flavonoid found in tea, broccoli, kale and spinach — and
luteolin — which is provided by peppers, carrots, cabbage and celery — were
both identified as cancer protective. Women who consumed the most of these
two flavonoids were 40 percent and 34 percent less likely, respectively, to
develop ovarian cancer compared to women who consumed the least ... A 2007
study published in the British Journal of Nutrition linked greater
consumption of carotenoid phytochemicals with a 67 percent lower risk of
ovarian cancer. This included not only beta-carotene, the oft-cited
carotenoid in deep-orange vegetables and fruits, but also alpha-carotene,
beta-cryptoxanthin, lutein and zeaxanthin — carotenoids found in a wide
range of red, orange, yellow and green vegetables" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
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Broccoli May Help Boost Aging Immune System - Science Daily, 3/6/08 -
"As we age, the ability of the immune system to
fight disease and infections and protect against cancer wears down as a
result of the impact of oxygen radicals on the immune system ... our study
shows that a chemical present in broccoli is capable of stimulating a wide
range of antioxidant defense pathways and may be able to interfere with the
age-related decline in immune function ... The UCLA team not only found that
the direct administration of sulforaphane in broccoli reversed the decline
in cellular immune function in old mice, but they witnessed similar results
when they took individual immune cells from old mice, treated those cells
with the chemical outside the body and then placed the treated cells back
into a recipient animal"
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Extract Of Broccoli Sprouts May Protect Against Bladder Cancer - Science
Daily, 2/28/08 - "A concentrated extract of freeze
dried broccoli sprouts cut development of bladder tumors in an animal model
by more than half" - [WebMD]
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Finding the Right Prostate Cancer Diet - WebMD, 2/15/08 -
"poultry and eggs double the risk of prostate cancer
progression ... orange and yellow vegetables, such as squash, yams, and
carrots, and cruciferous vegetables, such as broccoli, cut the risk of
recurrence by about half ... If you eat chicken or poultry, eat it without
the skin ... the men's overall PSA doubling time was nearly four times
slower after they began drinking pomegranate juice"
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Vegetables- and antioxidant-related nutrients, genetic susceptibility, and
non-Hodgkin lymphoma risk - Cancer Causes Control. 2008 Jan 17 -
"For the GSTM3 3-base insertion and higher total
vegetable intake, the risk was 0.56 (0.35-0.92, p interaction = 0.03); for
GSTP1 A114V and higher cruciferous vegetable intake, the risk was 0.52
(0.34-0.81, p interaction = 0.02); for OGG1 S326C and higher daily zinc
intake, the risk was 0.71 (0.47-1.08, p interaction = 0.04) and for XRCC3
T241M and higher green leafy vegetable intake, the risk was 0.63"
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Broccoli Good for the Heart - WebMD, 1/18/08 -
"The rats that had eaten the broccoli extract had three heart advantages
over the other rats: ... Better blood-pumping ability ... Less heart damage
during oxygen deprivation ... Higher levels of heart-health chemicals during
oxygen deprivation ... Broccoli's key nutrients include selenium and
sulforaphane, which may also curb cancer"
-
Is There an Anticancer Diet? - WebMD, 12/6/07 -
"Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and
cauliflower seem to reduce bladder cancer risk by about 40%"
-
Natural Chemical Found In Broccoli Helps Combat Skin Blistering Disease
- Science Daily, 8/20/07
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Broccoli May Help Cut Prostate Cancer - WebMD, 7/24/07 -
"Men who reported eating cauliflower more than once
per week were 52% less likely to be diagnosed with aggressive prostate
cancer than men who reported eating cauliflower less than once a month ...
Men who reported eating broccoli more than once per week were 45% less
likely to be diagnosed with aggressive prostate cancer than men who reported
eating broccoli less than once a month"
-
Eat
Your Broccoli: Study Finds Strong Anti-Cancer Properties In Cruciferous
Veggies - Science Daily, 5/17/07 -
"if you’re at all worried about cancer or at high
risk of cancer, especially of prostate or colon cancer, then increasing your
dietary intake of broccoli and other vegetables could be a good idea"
-
Boiling Broccoli Ruins Its Anti-cancer Properties, According To Study -
Science Daily, 5/15/07 - "Boiling appeared to have a
serious impact on the retention of those important glucosinolate within the
vegetables. The loss of total glucosinolate content after boiling for 30
minutes was: broccoli 77%, Brussel sprouts 58%, cauliflower 75% and green
cabbage 65%"
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Nutrients In Certain Vegetables May Provide Cancer-fighting Benefit -
Science Daily, 4/17/07 - "Dr. Singh's study is based
on phytochemicals, called isothiocyanates (ITCs), found in several
cruciferous vegetables and generated when vegetables are either cut or
chewed. His laboratory has found that phenethyl-ITC, or PEITC, is highly
effective in suppressing the growth of human prostate cancer cells at
concentrations achievable through dietary intake"
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Worried About Prostate Cancer? Tomato-broccoli Combo Shown To Be Effective
- Science Daily, 1/16/07 - "fed a diet containing 10
percent tomato powder and 10 percent broccoli powder to laboratory rats that
had been implanted with prostate cancer cells ... The tomato/broccoli combo
outperformed all other diets in shrinking prostate tumors ... The only
treatment that approached the tomato/broccoli diet's level of effectiveness
was castration ... To get these effects, men should consume daily 1.4 cups
of raw broccoli and 2.5 cups of fresh tomato, or 1 cup of tomato sauce, or ½
cup of tomato paste"
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Broccoli, Cauliflower May Fight Cancer - WebMD, 5/19/06
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Broccoli, Cauliflower And Genetic Cancer - Science Daily, 5/18/06 -
"cruciferous vegetables ... are abundant in
sulforaphane (SFN) ... those mice fed with an SFN-supplemented diet
developed significantly fewer and smaller tumors"
-
Crunchy Veggies Fight Cancer - WebMD, 4/5/06 -
"focused on a substance found in cruciferous
vegetables called phenethyl-ITC, or PEITC ... After 31 days of treatment,
the size of the tumors in the treated animals was about half that of the
untreated animals"
-
Curry And Cauliflower Could Halt Prostate Cancer - Science Daily,
1/15/06 - "The bottom line is that PEITC and
curcumin, alone or in combination, demonstrate significant cancer-preventive
qualities in laboratory mice, and the combination of PEITC and curcumin
could be effective in treating established prostate cancers"
-
Eat Your Veggies and Fight Cancer, Too - WebMD, 10/31/05
-
Broccoli May Protect Some Against Lung Cancer - WebMD, 10/27/05 -
"consumption of cruciferous vegetables was
associated with a 33%-37% reduction in lung cancer risk among people with an
inactive form of one of the two genes. Among those with an inactive form of
both genes, the reduction in risk provided by eating cruciferous vegetables
was doubled to more than 70%"
-
Broccoli May Fight Lung Cancer - WebMD, 9/15/05
-
Compounds Found In Cruciferous Vegetables Block Lung Cancer Progression
- Science Daily, 9/15/05 - "A family of compounds
found in cruciferous vegetables, such as broccoli, cauliflower, and
watercress, blocked lung cancer progression in both animal studies and in
tests with human lung cancer cells"
-
Broccoli Ingredient May Fight Bladder Cancer - WebMD, 8/3/05
-
Broccoli Packs Powerful Punch To Bladder Cancer Cells - Science Daily,
7/29/05 - "men who ate two or more half-cup servings
of broccoli per week had a 44 percent lower incidence of bladder cancer
compared to men who ate less than one serving each week ... The plant's kin,
which include cabbage, cauliflower, Brussels sprouts and kale, may all
contain similar disease-fighting phytochemicals"
-
Cruciferous veg, chili could slow or stop cancer cell growth - Nutra
USA, 4/20/05
-
Maximizing The Anti-Cancer Power Of Broccoli - Science Daily, 4/5/05 -
"For the consumer, who cannot readily hold the
temperature as low as 140 degrees, that means the best way to prepare
broccoli is to steam it lightly about 3 or 4 minutes--until the broccoli is
tough-tender"
- Ward off cancer with a
Japanese diet - MSNBC, 12/17/04 - "Cruciferous
vegetables make a unique contribution to good health. They contain natural
substances called glucosinolates that break down in the body to form indoles
and other compounds that fight cancer development in several different ways"
- An Apple a Day
for Cancer Prevention - WebMD, 10/18/04 - "Those
who ate both green leafy and cruciferous vegetables got "particularly
strong" cancer prevention protection"
- Crunchy
Veggies May Crush Breast Cancer - WebMD, 9/3/04
-
Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer
Cell Growth - Science Daily, 9/1/04 - "The
compound, in broccoli and other cruciferous vegetables ... sulforaphane
(SUL) ... We were surprised and pleased to find that SUL could block the
growth of breast cells that were already cancerous ... SUL's actions appear
similar to a group of anticancer drugs currently in use, such as Taxol"
-
Broccoli compound may protect against AMD - Nutra USA, 7/15/04
- Broccoli May
Prevent Blindness - WebMD, 7/13/04 -
"sulforaphane, the naturally occurring antioxidant
in broccoli and broccoli sprouts, protects the eye from damage caused by the
sun's ultraviolet light"
-
Cabbage to fight cancer? - Nutra USA, 5/11/04
- Broccoli Blocks
Prostate Cancer Cells - WebMD, 5/20/03
-
New Broccoli Compound Appears Promising Against Breast Cancer
- Intelihealth, 8/19/02 - "Called oxomate, the
synthetic compound works like its natural counterpart, sulforaphane, which
was recently identified as a cancer-preventive agent in broccoli and other
cruciferous vegetables (such as cabbage and Brussels sprouts). Both
compounds boost the body's production of phase II enzymes, which can
detoxify cancer-causing chemicals and reduce cancer risk ... But the natural
broccoli compound, sulforaphane, can be toxic in high doses ... It is also
difficult and expensive to synthesize ... oxomate was seven times less toxic
than sulforaphane ... In tests on female rats, those that were fed oxomate
after exposure to cancer-inducing chemicals had up to a 50 percent reduction
in the number of breast tumors"
- Broccoli Pill
Prevents Breast Cancer - WebMD, 8/19/02
- Broccoli Beats
Ulcers, Cancer - WebMD, 5/28/02
-
Broccoli Tea: Can't Find Enough Of A Good Thing - Natural Foods
Merchandiser, 5/02
-
Broccoli Finally Gets Respect - Intelihealth, 2/4/02
-
New research shows how broccoli beats cancer - Life Extension Magazine,
11/01 - "Sulforaphane is most highly concentrated in
broccoli, as well as in other cruciferous vegetables, such as Brussels
sprouts, cabbage and cauliflower ... animal studies to date have shown that
sulforaphane can dramatically reduce the number of malignant tumors,
reproduction, growth rate and size, as well as delay cancer onset"
-
Veggies Not Created Equal In Fighting Cancer - Intelihealth, 1/18/01 -
"But the Agriculture Department studied 71 types of
broccoli plants and found a 30-fold difference in the amounts of
glucoraphanin. Some had virtually none of it."
-
One More Reason To Eat Your Broccoli, Chemical Compounds Found to Prevent
Lung Cancer - WebMD, 8/25/00
-
Prostate Cancer and Cruciferous Vegetables - Life Extension Magazine,
7/00
-
Phytochemicals: Nutrients Whose Time Has Come - Nutrition Science News,
7/00
-
Betting on Broccoli - WebMD, 4/3/00
-
Fruits & Vegetables Slash Strokes - Nutrition Science News, 1/00
-
Can Cirrhosis be Prevented? - Nutrition Science News, 1/99
Abstracts:
-
Sulforaphane Targets the
TBX15/KIF2C Pathway to Repress Glycolysis and Cell Proliferation in Gastric
Carcinoma Cells - Nutr Cancer 2023;75(4):1263-1270 -
"The anti-tumor effects of sulforaphane were antagonized by down-regulation of
TBX15, up-regulation of KIF2C or addition of a PKM2 agonist. Sulforaphane can
reduce cell proliferation and PKM2-mediated glycolysis in gastric carcinoma
cells, apparently by activating the TBX15/KIF2C pathway" - See
sulforaphane at Amazon.com.
-
Sulforaphane Suppresses
MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect
of Butyl Benzyl Phthalate - Nutr Cancer 2022 Dec 21 -
"Collectively, these results demonstrated, for the first
time, that SFN regulates the miR-19/PTEN axis to exert protective effects
against BBP-mediated breast cancer promotion, suggesting a new potential role
for SFN (or SFN-rich foods) in phthalate antagonism"
-
Cruciferous vegetable
consumption and multiple health outcomes: an umbrella review of 41 systematic
reviews and meta-analyses of 303 observational studies - Food Funct 2022 Mar
30 - "Of the 41 meta-analyses, we observed suggestive
evidence for beneficial associations between gastric cancer, lung cancer,
endometrial cancer, and all-cause mortality. Moreover, 16 associations were
supported by weak evidence, including breast cancer, lung cancer, renal cell
carcinoma, bladder cancer, prostate cancer, ovarian cancer, endometrial cancer,
colon cancer, colorectal adenoma, colorectal neoplasm, non-Hodgkin lymphoma, and
total cancer" - See cruciferous vegetables supplements at Amazon.com.
-
Sulforaphane protects
myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
- Biochem Biophys Res Commun 2022 Mar 4 - "Myocardial
ischemia/reperfusion (I/R) injury poses a significant threat to human health.
High level of reactive oxygen species (ROS) and calcium overload are the
foremost causes of myocardial damage in I/R. Sulforaphane (SFN) is known for its
promising antioxidant effect ... this study demonstrated that SFN exerts
cardioprotective effect toward I/R injury through upregulating CaMKIIN2 and
down-regulating CaMKIIδ" - See sulforaphane at Amazon.com.
-
Brain Training and
Sulforaphane Intake Interventions Separately Improve Cognitive Performance in
Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have
More Beneficial Effects: Evidence from a Randomized Controlled Trial -
Nutrients 2021 Jan 25 - "Earlier studies have
demonstrated that a single-domain intervention, such as a brain-training (BT)
game alone and a sulforaphane (SFN) intake, positively affects cognition. This
study examined whether a combined BT and SFN intake intervention has beneficial
effects on cognitive function in older adults ... In a 12-week double-blinded
randomized control trial, 144 older adults were randomly assigned to one of four
groups: BT with SFN (BT-S), BT with placebo (BT-P), active control game (AT)
with SFN (AT-S), and active control game with placebo (AT-P) ... Participants
were asked to play BT or AT for 15 min a day for 12 weeks while taking a
supplement (SFN or placebo). We measured several cognitive functions before and
after the intervention period. Results: The BT (BT-S and BT-P) groups showed
more improvement in processing speed than the active control groups (AT-S and
AT-P). The SFN intake (BT-S and AT-S) groups recorded significant improvements
in processing speed and working memory performance unlike the placebo intake
groups (BT-P and AT-P). However, we did not find any evidence of the combined
intervention’s beneficial effects on cognition" - [Nutra
USA] - See sulforaphane at Amazon.com.
-
The Combination of
Sulforaphane and Fernblock ® XP Improves Individual Beneficial Effects in Normal
and Neoplastic Human Skin Cell Lines - Nutrients 2020 May 30 -
"we investigated in vitro the antioxidant/antineoplastic
efficacy and anti-aging activity of a dietary supplement containing sulforaphane
(SFN), a sulfur-isothiocyanate present in broccoli, combined with the patented
extract Fernblock® XP (FB), obtained from the tropical fern Polypodium
leucotomos. We evaluated the effect of SFN and FB, alone or in combination, on
migration ability, matrix metalloproteinases (MMP) production, neoangiogenic
potential and inflammasome activation in human WM115 and WM266-4 melanoma cells.
Moreover, the effects on MMPs and reactive oxygen species production, and IL-1β
secretion were studied in human normal keratinocytes. The SFN/FB combination
inhibited melanoma cell migration in vitro, MMP-1, -2, -3, and -9 production,
inflammasome activation and IL-1β secretion more efficiently than each
individual compound did. In normal keratinocytes, SFN/FB was more efficient than
SFN or FB alone in inhibiting MMP-1 and -3 production and IL-1β secretion in the
presence of a pro-inflammatory stimulus such as TNF-α. The potential use of
SFN/FB based supplements for the prevention of skin aging and as adjuvants in
the treatment of advanced melanoma is suggested" - See
Fernblock at Amazon.com. See
sulforaphane at Amazon.com and
iHerb.
-
The Role of Lysosome-Associated
Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane
- Cancer Prev Res (Phila) 2020 May 20 - "Prostate cancer
chemoprevention by sulforaphane (SFN), which is a metabolic by-product of
glucoraphanin found in broccoli, in preclinical models is associated with
induction of both apoptosis and autophagy ... The present study demonstrates a
role for lysosome-associated membrane protein 2 (LAMP2) in SFN-mediated
autophagy and apoptosis ... the present study reveals that induction of LAMP2 by
SFN inhibits its ability to induce apoptotic cell death at least in human
prostate cancer cells"
-
Sulforaphane Exhibits
Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK
and AKT Phosphorylation - Biol Pharm Bull. 2019;42(12):2109-2112 -
"Primary effusion lymphoma (PEL) ... Sulforaphane (SFN),
a natural compound found in cruciferous vegetables and broccoli sprouts,
modulates signaling pathways and epigenetic gene expression ... Our data and
previous literature indicate that SFN represses the phosphorylation of p38MAPK
and AKT, which results in PEL cell apoptosis"
-
Sulforaphane suppresses
the growth of triple-negative breast cancer stem-like cells in vitro and in vivo
- Cancer Prev Res (Phila). 2019 Jan 24 -
"Triple-negative breast cancer (TNBC) represents the poorest prognosis among all
of breast cancer subtypes with no currently available effective therapy. In this
study, we hypothesized that sulforaphane (SFN), a dietary component abundant in
broccoli and its sprouts, can inhibit malignant cell proliferation and tumor
sphere formation of cancer stem-like cells (CSCs) in TNBC ... In vivo, BalbC/nude
mice were supplemented with SFN before and after TNBC cell inoculation (daily
i.p. injection of 50mg SFN/kg for 5 and 3 weeks respectively), and effects of
SFN during mammary tumor initiation and growth were accessed with Nanostring
gene analysis. We found that SFN can inhibit cell proliferation and mammosphere
formation of CSCs in TNBC. Further analysis of gene expression in these TNBC
tumor cells revealed that SFN significantly decreases the expression of
cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various
stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3,
and Notch4. Our results suggest that SFN may control the malignant proliferation
of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression
and/or by inhibiting Cripto/Alk4 protein complex formation. Thus, the use of SFN
for chemoprevention of TNBC is plausible and warrants further clinical
evaluation"
-
Crucifers and related
vegetables and supplements for neurologic disorders: what is the evidence? -
Curr Opin Clin Nutr Metab Care. 2018 Sep 7 - "Much new evidence suggests that
neurological disorders are among the potential targets for this approach. This
evidence includes at least nine clinical studies of neurodevelopmental
conditions like autism spectrum disorder and schizophrenia, and there are a
great many studies in animal model systems, of neurodegenerative disorders like
Alzheimer's and Parkinson's diseases ... There is great promise for the regular
use of cruciferous vegetables or supplements containing standardized levels of
bioactives in the treatment and prevention of neurologic disorders"
- See
cruciferous vegetables supplements at Amazon.com.
-
Glucoraphanin Ameliorates
Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of
Metabolic Endotoxemia in Mice - Diabetes. 2017 Feb 16 -
"Thus, we examined whether dietary glucoraphanin, a
stable precursor of the Nrf2 inducer sulforaphane, ameliorates systemic energy
balance, chronic inflammation, insulin resistance, and NAFLD in high-fat diet
(HFD)-fed mice. Glucoraphanin supplementation attenuated weight gain, decreased
hepatic steatosis, and improved glucose tolerance and insulin sensitivity in
HFD-fed wild-type mice but not in HFD-fed Nrf2-knockout mice ... By promoting
fat browning, limiting metabolic endotoxemia-related chronic inflammation, and
modulating redox stress, glucoraphanin may mitigate obesity, insulin resistance,
and NAFLD" - [Nutra
USA] - See sulforaphane at Amazon.com
-
Prevention of
Carcinogen-Induced Oral Cancer by Sulforaphane - Cancer Prev Res (Phila).
2016 Jun 23 - "broccoli sprout extracts (BSE) ...
Compared with vehicle, sulforaphane significantly reduced the incidence and size
of 4NQO-induced tongue tumors in mice. A pilot clinical trial in 10 healthy
volunteers evaluated the bioavailability and pharmacodynamic activity of three
different BSE regimens, based upon urinary sulforaphane metabolites and NQO1
transcripts in buccal scrapings, respectively. Ingestion of sulforaphane-rich
BSE demonstrated the greatest, most consistent bioavailability ... Together, our
findings demonstrate preclinical chemopreventive activity of sulforaphane
against carcinogen-induced oral cancer, and support further mechanistic and
clinical investigation of sulforaphane as a chemopreventive agent against
tobacco-related HNSCC" - See
sulforaphane at Amazon.com.
-
Sulforaphane induces
adipocyte browning and promotes glucose and lipid utilization - Mol Nutr
Food Res. 2016 May 24 - "Obesity is closely related to
the imbalance of white adipose tissue storing excess calories, and brown adipose
tissue dissipating energy to produce heat in mammals. Recent studies revealed
that acquisition of brown characteristics by white adipocytes, termed
"browning," may positively contribute to cellular bioenergetics and metabolism
homeostasis ... SFN-induced browning of white adipocytes enhanced the
utilization of cellular fuel, and SFN is a promising strategy to combat obesity
and obesity-related metabolic disorder"
-
Sulforaphane reduces
advanced glycation end products (AGEs)-induced inflammation in endothelial cells
and rat aorta - Nutr Metab Cardiovasc Dis. 2016 Apr 21 -
"The present study demonstrated for the first time that
sulforaphane could inhibit inflammation in AGEs-exposed HUVECs and AGEs-infused
rat aorta partly by suppressing RAGE expression through its anti-oxidative
properties. Inhibition of the AGEs-RAGE axis by sulforaphane might be a novel
therapeutic target for vascular injury in diabetes"
-
Dietary Broccoli Lessens
Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and
Fed a Western or Control Diet - J Nutr. 2016 Mar;146(3):542-50 -
"The high-fat and high-sugar Westernized diet that is
popular worldwide is associated with increased body fat accumulation, which has
been related to the development of nonalcoholic fatty liver disease (NAFLD).
Without treatment, NAFLD may progress to hepatocellular carcinoma (HCC), a
cancer with a high mortality rate ... Adult 5-wk-old male B6C3F1 mice received a
control diet (AIN-93M) or a Western diet (high in lard and sucrose, 19% and 31%,
wt:wt, respectively), with or without freeze-dried broccoli ... Mice receiving
broccoli exhibited lower hepatic triglycerides (P < 0.001) and NAFLD scores (P <
0.0001), decreased plasma alanine aminotransferase (P < 0.0001), suppressed
activation of hepatic CD68(+) macrophages (P < 0.0001), and slowed initiation
and progression of hepatic neoplasm. Hepatic Cd36 was downregulated by broccoli
feeding (P = 0.006), whereas microsomal triglyceride transfer protein was
upregulated (P = 0.045), supporting the finding that dietary broccoli decreased
hepatic triglycerides" - [Nutra
USA] - See Jarrow Formulas BroccoMax,
Supports Liver Health, 60 Delayed Veggie Caps at Amazon.com.
-
Broccoli ingredient has positive influence on drug efficacy - Science Daily,
3/15/16 - "The enzyme AKR1C3 is a biochemical actor in
several metabolic pathways in the human body. It is also central in the efficacy
of a cancer drug that is currently still in development and clinical testing.
This drug, called PR-104A, is administered in an inactive form and is converted
into its active form inside the cancer cells by the AKR1C3 present there. The
researchers therefore used cell culture to investigate whether the broccoli
ingredient increased the efficacy of PR-104A. Their hypothesis was confirmed:
when the scientists pre-treated the colon cancer cells with sulforaphane, less
than a third of the usual dose of PR-104A was enough to kill the cancer cells.
"Since cancer drugs generally have strong side-effects, any approach that
reduces the dose of medication while maintaining efficacy is always welcome,"
says Sturla"
-
Sulforaphane
promotes murine hair growth by accelerating the degradation of
dihydrotestosterone - Biochem Biophys Res Commun. 2016 Feb 25 -
"Dihydrotestosterone (DHT) causes the regression of
human hair follicles in the parietal scalp, leading to androgenic alopecia (AGA)
... These results suggest that SFN treatment increases the amount of 3α-HSDs in
the liver, accelerates the degradation of blood DHT, and subsequently blocks the
suppression of hair growth by DHT"
-
Sulforaphene
suppresses growth of colon cancer-derived tumors via induction of glutathione
depletion and microtubule depolymerization - Mol Nutr Food Res. 2016 Feb 26
- "Cruciferous vegetables harbor a number of
isothiocyanates that have been recognized for their cancer-related properties.
Of these, sulforaphene (a naturally occurring derivative of sulforaphane) has
received little attention in studies of colon cancer and its mechanism of action
remains to be elucidated ... These findings demonstrate that sulforaphene may
contribute to the anti-tumor effects of cruciferous vegetables that contain
sulforaphene and other isothiocyanates such as sulforaphane" - See
sulforaphane at Amazon.com.
-
Sulforaphane
exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1
dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages
- Neurobiol Aging. 2016 Feb;38:1-10 - "Alzheimer's
disease (AD) is the most common neurodegenerative disorder worldwide, accounting
for most cases of dementia in elderly individuals, and effective therapies are
still lacking. This study was designed to investigate the anti-inflammatory
properties of sulforaphane against Aβ1-42 monomers in human THP-1 microglia-like
cells. The results showed that sulforaphane preferentially inhibited cathepsin
B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly
Aβ1-42 monomers, an effect that potently reduced excessive secretion of the
proinflammatory cytokine interleukin-1β (IL-1β) ... These findings suggest that
the phytochemical sulforaphane has a potential application in AD therapeutics"
-
Sulforaphane
produces antidepressant- and anxiolytic-like effects in adult mice - Behav
Brain Res. 2015 Dec 22 - "Increasing evidence suggests
that depression is accompanied by dysregulation of neuroimmune system.
Sulforaphane (SFN) is a natural compound with antioxidative, anti-inflammatory
and neuroprotective activities ... these findings demonstrated that SFN has
antidepressant- and anxiolytic-like activities in stressed mice model of
depression, which likely occurs by inhibiting the hypothalamic-pituitary-adrenal
(HPA) axis and inflammatory response to stress. These data support further
exploration for developing SFN as a novel agent to treat depression and anxiety
disorders"
-
Associations
between cruciferous vegetable intake and selected biomarkers among women
scheduled for breast biopsies - Public Health Nutr. 2015 Sep 2 -
"The present study sought to provide additional evidence
for the potential role of sulforaphane in histone acetylation and cell
proliferation. Here, we report that total cruciferous vegetable intake is
associated with decreased cell proliferation in breast DCIS tissue"
-
Effect of
Sulforaphane in Men with Biochemical Recurrence after Radical Prostatectomy
- Cancer Prev Res (Phila). 2015 May 12 - "Since the
phytochemical sulforaphane (SF) has been studied extensively as an anticancer
agent, we performed a double-blinded, randomized, placebo-controlled multicenter
trial with SF in 78 patients (mean age 69±6 years) with rising PSA levels after
radical prostatectomy. Treatment comprised daily oral administration of 60 mg of
a stabilized free SF for 6 months (M0 to M6) followed by 2 months without
treatment (M6 to M8) ... Mean changes in PSA levels between M6 and M0 were
significantly lower in the SF group (+0.099 ± 0.341 ng/ml) compared with placebo
(+0.620 ± 1.417 ng/ml; p = 0.0433). PSA doubling time was 86% longer in the SF
than in the placebo group (28.9 and 15.5 months, respectively). PSA increases
>20% at M6 were significantly greater in the placebo group (71.8%) than in the
SF group (44.4%); p=0.0163. Compliance and tolerance were very good. SF effects
were prominent within 3 months of intervention (M3 to M6)"
-
Cruciferous
Vegetables and Risk of Colorectal Neoplasms: A Systematic Review and
Meta-Analysis - Nutr Cancer. 2013 Dec 16 - "Evidence
shows cruciferous vegetables exhibit chemoprotective properties, commonly
attributed to their rich source of isothiocyanates ... Thirty-three articles
were included in the meta-analysis after a literature search of electronic
databases ... Results show a statistically significant inverse association
between cruciferous vegetable intake and colon cancer [OR = 0.84; 95% confidence
interval (CI): 0.72-0.98; P value heterogeneity < 0.001]. Broccoli in particular
exhibited protective benefits against colorectal (CRC) neoplasms (OR = 0.80; 95%
CI: 0.65-0.99; P value heterogeneity = 0.02). Stratification by GST genotype
reveals that the GSTT1 null genotype confers a reduction in CRC risk (OR = 0.78;
95% CI: 0.64-0.95; P value heterogeneity = 0.32). This study provides support to
the hypothesis that cruciferous vegetable intake protects against cancer of the
colon" - See cruciferous vegetables supplements at Amazon.com.
-
B-DIM
Impairs Radiation-Induced Survival Pathways Independently of Androgen Receptor
Expression and Augments Radiation Efficacy in Prostate Cancer - Cancer Lett.
2011 Dec 9 - "Increased consumption of cruciferous
vegetables is associated with decreased risk in prostate cancer (PCa). The
active compound in cruciferous vegetables appears to be the self dimerized
product [3,3'-diindolylmethane (DIM)] of indole-3-carbinol (I3C). Nutritional
grade B-DIM (absorption-enhanced) has proven safe in a Phase I trial in PCa ...
B-DIM inhibited cell growth in a dose-dependent manner in both PC-3 (AR-) and
C4-2B (AR+) cell lines. B-DIM was effective at increasing radiation-induced cell
killing in both cell lines, independently of AR expression. B-DIM inhibited
NF-κB and HIF-1α DNA activities and blocked radiation-induced activation of
these transcription factors in both PC-3 and C4-2B cells. In C4-2B (AR+) cells,
AR expression and nuclear localization were significantly increased by
radiation. However, B-DIM abrogated the radiation-induced AR increased
expression and trafficking to the nucleus, which was consistent with decreased
PSA secretion. In vivo, treatment of PC-3 prostate tumors in nude mice with
B-DIM and radiation resulted in significant primary tumor growth inhibition and
control of metastasis to para-aortic lymph nodes. These studies demonstrate that
B-DIM augments radiation-induced cell killing and tumor growth inhibition. B-DIM
impairs critical survival signaling pathways activated by radiation, leading to
enhanced cell killing. These novel observations suggest that B-DIM could be used
as a safe compound to enhance the efficacy of radiotherapy for
castrate-resistant PCa" - See
diindolylmethane at Amazon.com.
-
Cruciferous
vegetable consumption is associated with a reduced risk of total and
cardiovascular disease mortality - Am J Clin Nutr. 2011 May 18 -
"Overall, fruit and vegetable intake was inversely
associated with risk of total mortality in both women and men, and a
dose-response pattern was particularly evident for cruciferous vegetable intake.
The pooled multivariate hazard ratios (95% CIs) for total mortality across
increasing quintiles of intake were 1 (reference), 0.91 (0.84, 0.98), 0.88
(0.77, 1.00), 0.85 (0.76, 0.96), and 0.78 (0.71, 0.85) for cruciferous
vegetables (P < 0.0001 for trend) and 0.88 (0.79, 0.97), 0.88 (0.79, 0.98), 0.76
(0.62, 0.92), and 0.84 (0.69, 1.00) for total vegetables (P = 0.03 for trend).
The inverse associations were primarily related to cardiovascular disease
mortality but not to cancer mortality"
-
Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl
Isothiocyanate in a Mouse Model of Prostate Cancer - J Natl Cancer Inst.
2011 Feb 17 - "This study was undertaken to determine
the chemopreventative efficacy of phenethyl isothiocyanate (PEITC), a bioactive
constituent of many edible cruciferous vegetables, in a mouse model of prostate
cancer, and to identify potential biomarker(s) associated with PEITC response
... Administration of PEITC (3 μmol/g diet) decreased incidence (PEITC diet vs
control diet, mean = 21.65 vs 57.58%, difference = -35.93%, 95% confidence
interval = -45.48% to -13.10%, P = .04) as well as burden (affected area) (PEITC
diet vs control diet, mean = 18.53% vs 45.01%, difference = -26.48%, 95%
confidence interval = -49.78% to -3.19%, P = .02) of poorly differentiated
tumors in the dorsolateral prostate of transgenic mice compared with control
mice, with no toxic effects. PEITC-mediated inhibition of prostate
carcinogenesis was associated with induction of autophagy and overexpression of
E-cadherin in the dorsolateral prostate. However, PEITC treatment was not
associated with a decrease in cellular proliferation, apoptosis induction, or
inhibition of neoangiogenesis. Plasma proteomics revealed distinct changes in
the expression of several proteins (eg, suppression of clusterin protein) in the
PEITC-treated mice compared with control mice. Conclusions In this transgenic
model, dietary PEITC suppressed prostate cancer progression by induction of
autophagic cell death. Potential biomarkers to assess the response to PEITC
treatment in plasma were identified"
-
Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and
vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4
pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep
27 - "Chronic inflammation plays pivotal roles in both
cancer and cardiovascular diseases. A large body of evidence suggests that high
intake of cruciferous vegetables is closely related with low risk of these
disorders ... Taken all together, adhesion molecules are confirmed to be the
novel targets of sulphoraphane in preventing inflammatory insult to endothelial
cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors
such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the
subsequent expression of adhesion molecules. These data suggested a novel
inflammatory pathway mediated by sulphoraphane" - See
sulforaphane at Amazon.com.
-
Intake of
Cruciferous Vegetables Modifies Bladder Cancer Survival - Cancer Epidemiol
Biomarkers Prev. 2010 Jun 15 - "After an average of 8
years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder
cancer. After adjustment for other prognostic factors, a strong and significant
inverse association was observed between bladder cancer mortality and broccoli
intake, in particular raw broccoli intake (>/=1 versus <1 serving per month; HR
for overall death, 0.57; 95% CI, 0.39-0.83; HR for disease-specific death, 0.43;
95% CI, 0.25-0.74). There were no significant associations for total vegetables,
total fruits, or other individual cruciferous vegetables" - See
sulforaphane at Amazon.com.
-
Effects
of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and
apoptosis in LNCaP human prostate cancer cells - Int J Food Sci Nutr.
2010 May;11(7):324-36 - "Cruciferous vegetable
consumption is associated with decreased risk of several cancers, including
prostate cancer. Gluconasturtiin, one of the predominant glucosinolates in
cruciferous vegetables, is hydrolyzed to yield phenylethyl isothiocyanate
(PEITC). PEITC absorption and metabolism in humans involves glutathione
conjugation followed by conversion via the mercapturic acid pathway to an
N-acetylcysteine (NAC) conjugate that is excreted in the urine. We observed
an inhibitory effect of PEITC and its metabolite, NAC-PEITC, on cancer cell
proliferation, cell-cycle progression, and apoptosis in LNCaP human prostate
cancer cells. PEITC and NAC-PEITC suppressed LNCaP cell proliferation in a
dose-dependent manner, and exposure to 5 microM PEITC or NAC-PEITC reduced
cell proliferation by 25% and 30%, respectively. Cell-cycle analysis
revealed that cells treated with 5 microM PEITC or NAC-PEITC arrested at the
G(2)/M phase. In addition, the percentage of cells in the S phase decreased
from 46% to 25% following 48 h of incubation with PEITC or NAC-PEITC. The
G(2)/M-phase cell-cycle arrest of LNCaP cells grown in the presence of PEITC
or NAC-PEITC is correlated with the downregulation of Cdk1 and cyclin B(1)
protein expression. Apoptosis was observed at the later stages of 24-h and
48-h treatments with 5 microM PEITC and NAC-PEITC. In conclusion, PEITC and
NAC-PEITC are potential chemopreventive/chemotherapeutic agents against
LNCaP human prostate cancer cells"
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Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a
Proinflammatory State - Arterioscler Thromb Vasc Biol. 2009 Sep 3 -
"Treatment with sulforaphane, a dietary antioxidant,
activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site
in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC
activation via Nrf2 ... Nrf2 prevents ECs at the atheroprotected site from
exhibiting a proinflammatory state via the suppression of p38-VCAM-1
signaling. Pharmacological activation of Nrf2 reduces EC activation at
atherosusceptible sites and may provide a novel therapeutic strategy to
prevent or reduce atherosclerosis" - See
sulforaphane at Amazon.com.
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Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression
To Attenuate Migration and Invasion of Breast Cancer Cells - J Agric
Food Chem. 2008 Dec 5 - "Indole-3-carbinol
(I3C), a major indole metabolite in cruciferous vegetables, has been shown
to inhibit invasion of breast cancer cells ... Migration, invasion, and
MMP-2 activity of MCF-7 breast cancer cells were dose-dependently inhibited
by I3C. In addition, the MMP-2 mRNA level was also reduced by I3C ... In
addition, I3C inhibited the extracellular signal-regulated kinase (ERK)
signaling pathway in MCF-7 cells. The results suggest that I3C inhibits
MMP-2 expression by blocking the ERK/Sp1-mediated gene transcription to
attenuate migration and invasion of breast cancer cells" - See
indole-3-carbinol at Amazon.com.
-
Consumption of Raw Cruciferous Vegetables is Inversely Associated with
Bladder Cancer Risk - Cancer Epidemiol Biomarkers Prev. 2008
Apr;17(4):938-44 - "We observed a strong and
statistically significant inverse association between bladder cancer risk
and raw cruciferous vegetable intake (adjusted OR for highest versus lowest
category = 0.64; 95% CI, 0.42-0.97), with a significant trend (P = 0.003);
there were no significant associations for fruit, total vegetables, or total
cruciferous vegetables ... These data suggest that cruciferous vegetables,
when consumed raw, may reduce the risk of bladder cancer, an effect
consistent with the role of dietary isothiocyanates as chemopreventive
agents against bladder cancer"
-
Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the
Redox Cycling of the Thioredoxin Superfamily - J Agric Food Chem. 2007
Dec 29 - "the results of the present study indicate
that the consumption of broccoli triggers cardioprotection by generating a
survival signal through the activation of several survival proteins and by
redox cycling of thioredoxins"
-
Cruciferous vegetables, genetic polymorphisms in glutathione s-transferases
m1 and t1, and prostate cancer risk - Nutr Cancer. 2004;50(2):206-13 -
"two or more servings per month of cruciferous vegetables may reduce risk of
prostate cancer"
-
Breast Cancer Risk in Premenopausal Women Is Inversely Associated with
Consumption of Broccoli, a Source of Isothiocyanates, but Is Not Modified by
GST Genotype
- J Nutr. 2004 May;134(5):1134-1138 - "These data
indicate that cruciferous vegetables may play an important role in
decreasing the risk of premenopausal breast cancer"
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