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Cystic Fibrosis

Alternative News:

• Supplemental antioxidants may reduce exacerbations in cystic fibrosis - Science Daily, 7/2/18 - "During the 16-week study of 73 patients (36 received supplemental antioxidants), 53 percent of the antioxidant-treated group experienced 28 exacerbations, compared to 68 percent of the control group who experienced 39 exacerbations"
• Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial - Am J Clin Nutr. 2012 May 30 - "Magnesium is one of the most important minerals in the body ... randomly assigned to receive magnesium (n = 22; 300 mg/d) or placebo (n = 22) for 8 wk with a 4-wk washout period between trials ... Shwachman-Kulczycki (SK) score ... Magnesium administration had a beneficial effect on clinical variables assessed by the SK score (change: 4.48 points after magnesium compared with -1.30 points after placebo"
• Gastric Emptying, Incretin Hormone Secretion, and Postprandial Glycemia in Cystic Fibrosis--Effects of Pancreatic Enzyme Supplementation - J Clin Endocrinol Metab. 2011 Mar 9 - "CF patients consumed a radiolabeled mashed potato meal on 2 separate days, together with four capsules of Creon Forte (100,000 IU lipase) or placebo. Healthy subjects consumed the meal once, without pancreatic enzymes. Main Outcome Measures: Gastric emptying was measured using scintigraphy, and blood was sampled frequently for blood glucose and plasma glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon concentrations. Results: CF patients had more rapid gastric emptying (P < 0.001), impaired secretion of GLP-1 (P < 0.01) and GIP (P < 0.001), and greater postprandial glycemic excursions (P < 0.001) than healthy subjects. Pancreatic enzyme supplementation normalized gastric emptying and GLP-1 secretion and tended to increase glucagon (P = 0.08), but did not completely restore GIP secretion or normalize postprandial blood glucose. There was an excellent correlation between gastric emptying and blood glucose concentration at 60 min (R = 0.75; P = 0.01). Conclusions: Pancreatic enzyme supplementation plays an important role in incretin secretion, gastric emptying, and postprandial hyperglycemia in CF" - See enzyme formulas at iHerb.
• Vitamin D may treat or prevent allergy to common mold - Science Daily, 8/16/10 - "The environmental mold, Aspergillus fumigatus, is one of the most prevalent fungal organisms inhaled by people. In the vast majority, it is not associated with disease. However, in asthmatics and in patients with Cystic Fibrosis (CF), it can cause significant allergic symptoms. Up to 15% of CF patients develop a severe allergic response called Allergic Bronchopulmonary Aspergillosis (ABPA) ... adding vitamin D not only substantially reduced the production of the protein driving an allergic response, but it also increased production of the proteins that promote tolerance" - See vitamin D at Amazon.com.
• Antioxidant found in vegetables has implications for treating cystic fibrosis - 11/20/09 - "a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration ... the antioxidant thiocyanate normally existing in the body protects lung cells from injuries caused by accumulations of hydrogen peroxide and hypochlorite, the active ingredient in household bleach. These potentially harmful chemicals are made by the body as a reaction to infection and injury. In addition, thiocyanate also protects cells from hypochlorite produced in reactions involving MPO, an enzyme released from germ-fighting white blood cells during inflammation"
• Before A CT Scan Or Angiogram, Many People Should Take Inexpensive Drug To Protect Kidneys - Science Daily, 2/18/08 - "The inexpensive drug, called N-acetylcysteine, can prevent serious kidney damage that can be caused by the iodine-containing "dyes" that doctors use to enhance the quality of such scans ... N-acetylcysteine is already widely used to clear mucus in cystic fibrosis patients, and to treat overdoses of acetaminophen" - See n-acetyl cysteine at Amazon.com.
• Vitamin D Insufficiency Common in Cystic Fibrosis Patients - Medscape, 12/27/07
• High-dose Ibuprofen May Slow Cystic Fibrosis Lung Disease -- Especially In Children - Science Daily, 10/16/07
• Vitamins A and E and pulmonary exacerbations in patients with cystic fibrosis - J Pediatr Gastroenterol Nutr. 2007 Sep;45(3):347-53 - "Reduced serum levels of vitamin A and E even in the normal range are associated with an increased rate of pulmonary exacerbations in CF"
• Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover - Pediatrics. 2005 May;115(5):1325-31 - "Vitamin K1 deficiency is common among children with CF, and routine supplements should be considered. Through its role in the carboxylation of OC, vitamin K deficiency may be associated with an uncoupling of the balance between bone resorption and bone formation"
• The Case for Curry: Turmeric as Medical Treatment - Natural Foods Merchandiser, 6/04
• Vitamin K supplementation in cystic fibrosis - Arch Dis Child. 2003 Nov;88(11):974-5 - "a increased vitamin K intake may have significant health benefits for children with CF"
• Coping with Cystic Fibrosis? - Dr. Weil, 10/16/02
• Simple Sugar May Prevent Lung Infections in CF Patients - Medscape, 10/12/00 - See Xylitol products at iHerb.

Other News:

• All his life, his health was poor. It took more than 50 years to find out why - Washington Post, 12/21/19
• Women With Cystic Fibrosis Can Have Safe And Successful Fertility Treatment - Science Daily, 6/30/09
• Protein Opens Hope Of Treatment For Cystic Fibrosis Patients - Science Daily, 9/10/08
• New Drug Hope For Cystic Fibrosis Patients - Science Daily, 9/9/08
• Elavil for Cystic Fibrosis? - WebMD, 3/31/08
• Promising New Research For Cystic Fibrosis - Science Daily, 3/18/08
• Secondhand Smoke Exposure Worsens Cystic Fibrosis - Science Daily, 1/29/08
• Ibuprofen May Aid Cystic Fibrosis Lungs - WebMD, 11/30/07
• Cystic Fibrosis: Ibuprofen Associated With Slower Lung Function Decline In Children, Study Suggests - Science Daily, 11/30/07
• Breathe Deep: Which Patients Could Benefit From Inhaled Steroids In Cystic Fibrosis? - Science Daily, 11/29/07
• Maze of cystic fibrosis is getting a little clearer - USA Today, 2/12/06
• Common Food Preservative Might Provide Treatment For Cystic Fibrosis - Science Daily, 1/27/06
• Researchers Find Effective, Cheap Treatment For Cystic Fibrosis Lung Disease - Science Daily, 1/25/06
• Treatment Shows Long-term Benefits For Cystic Fibrosis Patients - Science Daily, 1/23/06
• Effective, Cheap Treatment for Cystic Fibrosis Lung Disease - Doctor's Guide, 1/19/06
• Cystic Fibrosis Advance Shows Promise - WebMD, 1/18/06
• Dornase Alpha (Pulmozyme) May Reduce Inflammation for Cystic Fibrosis - Doctor's Guide, 11/24/05
• Little Evidence Behind Bronchodilator Therapy for Cystic Fibrosis - Doctor's Guide, 10/26/05
• Little Evidence Behind Bronchodilator Therapy For Cystic Fibrosis - Science Daily, 10/26/05
• FDA Grants Orphan Drug Designation for PTC124 for Treatment of Cystic Fibrosis - Doctor's Guide, 12/8/04
• Surprising Finding Could Lead to New Treatment for Cystic Fibrosis - Doctor's Guide, 7/1/04
• rGH Injections Improve CF Symptoms - Physician's Weekly, 2/16/04
• Gentamycin May Correct Some Genetic Mutations In Cystic Fibrosis - Doctor's Guide, 10/15/03
• Azithromycin Treatment Improved Pulmonary Function and Nutritional Status in Patients With Cystic Fibrosis - Doctor's Guide, 10/2/03
• Macrolides Benefit Patients With Cystic Fibrosis Although More Studies Are Needed - Doctor's Guide, 7/30/03
• Tobi (Tobramycin) Cuts In Half Hospitalizations For Young Cystic Fibrosis Patients With Asymptomatic Or Mild Lung Disease - Doctor's Guide, 6/4/03
• Imaging Technology offers Non-Invasive Option for Monitoring Pulmonary Inflammation in Cystic Fibrosis Patients - Doctor's Guide, 5/26/03
• Early Bronchoscopy Justified In Cystic Fibrosis Lung Transplant Patients - Doctor's Guide, 3/21/03
• Risk For Digestive Tract Cancers Increases In Adult Cystic Fibrosis Patients - Doctor's Guide, 3/14/03
• Europe Grants Orphan Designation To Duramycin (Moli1901) For Treatment Of Cystic Fibrosis - Doctor's Guide,1/8/03
• Demegen Receives Orphan Drug Designation for P113D For Treatment of Cystic Fibrosis - Doctor's Guide, 11/5/02
• Polymorphism Underlies Liver Disease In Paediatric Cystic Fibrosis - Doctor's Guide, 10/11/02
• High-Dose Salmeterol Effective In Mild To Moderate Cystic Fibrosis - Doctor's Guide, 10/8/02
• Lung Transplants Warranted In Cystic Fibrosis - Doctor's Guide, 10/7/02
• Drug [azithromycin] Helps Cystic Fibrosis Patients - Intelihealth, 10/4/02
• Antibiotic Could Help Cystic Fibrosis - WebMD, 9/26/02
• Azithromycin Promising In Cystic Fibrosis Treatment - Doctor's Guide, 9/26/02
• Long Term Survival in Cystic Fibrosis Patients Not Improved by Neonatal Screening - Doctor's Guide, 9/4/02
• Phenotype and Genotype Correlate in Cystic Fibrosis - Doctor's Guide, 8/30/02
• Alcaligenes Infection Does Not Worsen Cystic Fibrosis - Doctor's Guide, 8/9/02
• Aerosol Antibiotic Works for Pseudomonas Aeruginosa in Patients with Cystic Fibrosis - Doctor's Guide, 8/6/02
• Tobramycin For Cystic Fibrosis Improves Therapeutic Ratio Compared to Parenteral Aminoglycosides - Doctor's Guide, 7/25/02
• Itraconazole Effective For Allergic Bronchopulmonary Aspergillosis In Cystic Fibrosis - Doctor's Guide, 7/23/02
• Testing Allows Early Pseudomonas aeruginosa Detection In Cystic Fibrosis - Doctor's Guide, 6/12/02
• High Triglycerides Common In Cystic Fibrosis Patients - Doctor's Guide, 6/11/02
• Short-Term Megestrol Helps Cystic Fibrosis Children Gain Weight - Doctor's Guide, 5/30/02
• More Attention Should Be Paid to Bone Status Of Cystic Fibrosis Patients - Doctor's Guide, 5/13/02
• Role of Insulinopenia in Cystic Fibrosis-Related Diabetes - Doctor's Guide, 4/9/02
• New Hope for Cystic Fibrosis - WebMD, 12/27/01
• Insulin-Like Growth Factor-1 Does Not Promote Linear Growth In Children With Cystic Fibrosis - Doctor's Guide, 12/20/01
• Which CF Patients Need New Lungs? - WebMD, 12/4/01
• New Theory Proposed For Cystic Fibrosis Infections - Intelihealth, 11/20/01
• Instilled DNase Dissolves Mucus Plugs in Cystic Fibrosis - Doctor's Guide, 11/9/01
• Cystis fibrosis testing goes mainstream - USA Today, 10/1/01
• Forced Ionization By Salt Sublimation May Improve Respiratory Symptoms in Cystic Fibrosis - Doctor's Guide, 6/8/01
• Fluoroquinolones Appear Safe In Children With Cystic Fibrosis - Doctor's Guide, 6/8/01
• Finding May Shed New Light On Causes Behind Cystic Fibrosis - Intelihealth, 2/28/01
• Tobi (Tobramycin) Improved Lung Function in Cystic Fibrosis Better Than Colomycin (Colistin) - Doctor's Guide, 6/7/00
• Cystic Fibrosis Patients Showed Significant Improvement With HP-3 - Doctor's Guide, 12/13/99
• Potential new approach to cystic fibrosis treatment reported - CNN, 10/9/99
• Airway Salt Concentrations Reduce Antimicrobial Efficacy In Cystic Fibrosis Patients - Doctor's Guide, 9/8/99
• CF Patients Have Higher Immune Responses To C. Albicans - Doctor's Guide, 6/14/99
• More Than Half Of Women With Cystic Fibrosis Experience Incontinence - Doctor's Guide, 6/14/99
• Third-Generation Cephalosporins Linked To Bacteria Infection In CF Patients - Doctor's Guide, 6/10/99
• Nationwide Survey Shows Anti-Inflammatory Agents Are Underused In Cystic Fibrosis - Doctor's Guide, 4/6/99
• Gene Therapy Can Help Improve Cystic Fibrosis - Doctor's Guide, 3/19/99
• Scientists Discover How Cystic Fibrosis Damages Lungs - Doctor's Guide, 12/23/98
• Pamidronate Can Reverse Osteoporosis From Transplant, Cystic Fibrosis Drugs - Doctor's Guide, 10/19/98
• TOBI Maintains Lung Function Improvements In CF Patients - Doctor's Guide, 10/16/98
• Missing Intestinal Bacterium Linked To Kidney Stones In CF Patients - Doctor's Guide, 9/25/98
•  Cystic Fibrosis May Be Linked To Obstructive Pulmonary Disease - Doctor's Guide, 6/26/98
• Tobi Remains Effective In CF Patients After 11 Months - Doctor's Guide, 6/16/98
• Genetic Tests May Not Be Reliable For CF Diagnosis - Doctor's Guide, 5/20/98
• Pulmozyme Approved For Kids With Cystic Fibrosis - Doctor's Guide, 3/2/98
• Study Shows Intermittent Tobi Therapy Effective In Cystic Fibrosis Patients - Doctor's Guide, 1/7/98
• Tobi Cleared For Lung Infection In Cystic Fibrosis Patients - Doctor's Guide, 12/23/97
• FDA Committee Recommends Approval Of Tobi For CF Lung Infections - Doctor's Guide, 11/21/97
• Researchers Advance Understanding of the Ion Channel Involved in Cystic Fibrosis - Doctor's Guide, 9/17/97
• NIH Panel Makes Recommendations for Genetic Testing for Cystic Fibrosis - Doctor's Guide, 4/17/97
• Key Peptide Responsible In Cystic Fibrosis-Associated Lung Infection - Doctor's Guide, 2/21/97
• Pulmozyme for Cystic Fibrosis Cleared by the FDA - Doctor's Guide, 12/2/96