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Anti-aging Research >
Antidepressants & Psychotropics > Prozac®
(fluoxetine hydrochloride)
Prozac® (fluoxetine hydrochloride) (Eli Lilly and Co.)
Related Topics:
Alternative News:
-
Efficacy and
Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial
- Phytother Res. 2013 Jul 6 - "60 patients diagnosed
with MDD were randomized in a 1:1:1 ratio for six weeks observer-masked
treatment with fluoxetine (20 mg) and curcumin (1000 mg) individually or their
combination ... curcumin was well tolerated by all the patients. The proportion
of responders as measured by the HAM-D17 scale was higher in the combination
group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups;
however, these data were not statistically significant (P = 0.58).
Interestingly, the mean change in HAM-D17 score at the end of six weeks was
comparable in all three groups (P = 0.77). This study provides first clinical
evidence that curcumin may be used as an effective and safe modality for
treatment in patients with MDD without concurrent suicidal ideation or other
psychotic disorders" - See
curcumin products at Amazon.com
 .
News & Research:
-
Prozac (fluoxetine) - rxlist.com
-
St. John's Wort Equivalent to World's Best-selling Antidepressant -
herbs.org
-
Fluoxetine at drugstore.com
-
Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other
New-Generation Antidepressants - Doctor's Guide, 1/29/09 -
"Sertraline and escitalopram were found to be the
best antidepressants overall in terms of efficacy and acceptability.
Sertraline was more efficacious than duloxetine (by 30%); than both
duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%);
paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more
efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by
35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and
escitalopram, mirtazapine and venlafaxine were also more efficacious than
these other drugs ... However, escitalopram and sertraline showed the best
profile of acceptability, leading to significantly fewer discontinuations of
treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and
venlafaxine"
-
Medication For Depression Can Also Fight Cancer Drug Resistance -
Science Daily, 12/18/08
-
Omega-3 EPA may benefit depressives, says study - Nutra USA, 4/7/08 - [Abstract]
- "were randomly assigned to receive a daily EPA
supplement (1000 mg, supplied by Minami Nutrition, Belgium), or 20 mg
fluoxetine daily, or a combination of the two for two months ... At the end
of the study, data from the 48 people who finished the study showed a 50 per
cent reduction in HDRS scores for people in the EPA group, a 56 per cent
reduction in people in the fluoxetin group, and a 81 per cent reduction in
people in the combined intervention group" - See
Mega Twin EPA at Amazon.com.
-
Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic
acid and fluoxetine, separately and in combination, in major depressive
disorder - Aust N Z J Psychiatry. 2008 Mar;42(3):192-8 -
"EPA + fluoxetine combination was significantly
better than fluoxetine or EPA alone from the fourth week of treatment.
Fluoxetine and EPA appear to be equally effective in controlling depressive
symptoms. Response rates (>/=50% decrease in baseline HDRS) were 50%, 56%
and 81% in the fluoxetine, EPA and combination groups, respectively"
- See Mega Twin EPA at Amazon.com.
-
First Head-to-Head Study Suggests Significantly Greater Symptom Improvement
for Olanzapine and Fluoxetine Combination Capsules Compared to Lamotrigine
in Bipolar Depression - Doctor's Guide, 5/30/06
-
Study Suggests Olanzapine and Fluoxetine Combination Capsules Improve
Symptoms of Treatment-Resistant Depression - Doctor's Guide, 5/30/06
-
Popularity Doesn't Necessarily Make Prozac Best Antidepressant Choice -
Doctor's Guide, 12/6/05
-
Eszopiclone (Lunesta) With Fluoxetine (Prozac) Improves Comorbid Insomnia in
Depression - Doctor's Guide, 5/30/05
-
Mirtazapine Betters Major SSRIs for Treatment of Depression - Doctor's
Guide, 5/27/05 - "A meta-analysis of clinical trials involving more than
2,500 subjects suggests that treatment of depression with mirtazapine
(Remeron) results in a more rapid onset of clinical improvement compared to
treatment with fluoxetine, paroxetine, and sertraline (all SSRIs)" - See
Remeron (mirtazapine) at
OffshoreRx1.com.
- Prozac: A
Weight-Loss Drug? - WebMD, 7/12/04
-
Fluoxetine Appears Monotherapy Safe, Effective For Bipolar Type Major
Depressive Episode - Doctor's Guide, 3/16/04
-
Treatment Adequacy Appears More Likely With Venlafaxine Extended Release
Than Fluoxetine In Depressed Patients - Doctor's Guide, 2/10/04
-
FDA Approves Symbyax (Olanzapine and Fluoxetine), First Medication for
Bipolar Depression - Doctor's Guide, 12/30/03
-
Olanzapine/Fluoxetine Combination Treats Bipolar Depression Without
Triggering Mania - Doctor's Guide, 10/14/03
-
Fluoxetine Is Tx of Choice for Bulimia, but Most Continue to Binge -
Clinical Psychiatry News, 9/03
-
Citalopram Effective in Patients Who React Adversely to Fluoxetine -
Doctor's Guide, 6/5/03
-
Fluoxetine Treatment For Depression Should Continue For Set Period For
Proper Assessment - Doctor's Guide, 4/9/03
-
Fluoxetine Useful In Treating Childhood Anxiety Disorders - Doctor's
Guide, 4/2/03
-
Fluoxetine Mildly Effective in Elderly Patients with Dysthymic Disorder
- Doctor's Guide, 3/7/03
-
Olanzapine/Fluoxetine Combination Effective In Psychotic Depression -
Doctor's Guide, 1/20/03
- SSRIs May Increase
Risk of Gastrointestinal Bleeding - Medscape, 1/17/03 -
"Selective serotonin reuptake inhibitors (SSRIs)
are associated with an increased risk of gastrointestinal (GI) bleeding,
especially when combined with nonsteroidal anti-inflammatory drugs (NSAIDs)"
- Examples of SSRIs are Prozac,
Paxil and
Zoloft.
-
FDA Approves Prozac For Pediatric Use To Treat Depression, Obsessive
Compulsive Disorder - Doctor's Guide, 1/6/03
-
FDA approves Prozac for children - USA Today, 1/3/03
-
Fluoxetine at 20 mg Safe in Children - Clinical Psychiatry News, 12/02
-
Age May Affect Rate of Response To Fluoxetine - Clinical Psychiatry
News, 10/02
-
Olanzapine/Fluoxetine Combination for Treatment-Resistant and Psychotic
Depression Raises No New Safety Issues - Doctor's Guide, 10/9/02
-
SNRI Reboxetine Safe and Effective Adjunct for SSRI Fluoxetine Partial
Responders in Major Depression - Doctor's Guide, 10/8/02
-
Premenstrual Dysphoric Syndrome Cut By Daily Fluoxetine - Doctor's
Guide, 9/24/02
- Fluoxetine Effective
in Premenstrual Dysphoric Disorder - Medscape, 9/6/02
-
Poor Response To Fluoxetine Antidepressant Therapy Appears Linked To High
Serum Cholesterol - Doctor's Guide, 9/5/02 -
"patients with elevated
cholesterol levels were significantly
more likely to be nonresponders to fluoxetine therapy than were patients
with nonelevated cholesterol levels"
-
Olanzapine-Fluoxetine for Treatment-Resistant Depression - Doctor's
Guide, 9/2/02
-
Boosting Fluoxetine As Effective As Adding Lithium Or Desipramine For
Unresponsive Depression - Doctor's Guide, 8/30/02
-
Olanzapine-Fluoxetine Better Than Olanzapine Alone For Psychotic Depression
- Doctor's Guide, 8/29/02
-
Extended Use of Clonazepam with Fluoxetine Safe and Effective for Major
Depression in Outpatients - Doctor's Guide, 8/23/02
-
Increasing Drug Dose Appears Effective for Depressed Patients Who Relapse on
Fluoxetine - Doctor's Guide, 8/20/02
-
Venlafaxine Appears More Effective Than Fluoxetine In Treating Depression
With Concomitant Anxiety - Doctor's Guide, 8/9/02 -
"An overall response was seen in 75 percent of
patients receiving venlafaxine and 51
percent of patients receiving fluoxetine. At their final visit, 59 percent
of patients taking venlafaxine and 40 percent taking fluoxetine were
virtually asymptomatic"
- Olanzapine and Fluoxetine
Improve Quality of Life in Bipolar Patients - Doctor's Guide, 6/25/02
-
Sertraline Beats Fluoxetine for Severe Depression - Doctor's Guide,
5/22/02
-
Olanzapine-Fluoxetine Combination Shows Promise for Psychotic Major
Depression - Doctor's Guide, 5/22/02
-
Response to Antidepressent Therapy Appears Age Dependent - Doctor's
Guide, 5/15/02
-
Characterising Fluvoxamine Metabolism - Doctor's Guide, 4/19/02 -
"the higher fluvoxamine doses inhibited CYP1A2 and
CYP2C19 by approximately 75 to 80 per cent. The inhibition with the lower
doses was around 40 to 50 per cent"
-
Generic Fluoxetine May Offer Lower Bioequivalence - Clinical Psychiatry
News, 4/02
- False Alarm:
Study Doesn't Link Prozac to Cancer - WebMD, 3/28/02
-
Fluoxetine Effective In Women With Fibromyalgia - Doctor's Guide,
3/28/02
- Generic Prozac:
Can You Trust It? - WebMD, 8/28/01
-
Generic Version Of Prozac Opens - Intelihealth, 8/21/01
- Prozac Goes
Generic - WebMD, 8/3/01
- Prozac Effective in
Sustaining Remission of Eating Disorders - Doctor's Guide, 4/24/01 -
"followed for one year 35 anorexia outpatients who
were discharged from the hospital after they recovered a significant amount
of their body weight. Fluoxetine was prescribed for 16 of the patients while
the remainder took a placebo. Among the patients on fluoxetine, 10 of 16 did
not relapse and maintained a healthy body weight, while only three out of 19
on placebo were successful"
-
Depression Remission Better With Venlafaxine Than Selective Serotonin Uptake
Inhibitors - Doctor's Guide, 3/1/01 -
"Remission rates among depressed patients treated
with venlafaxine are significantly higher than among patients treated with
selective serotonin reuptake inhibitors."
- FDA
approves once-a-week Prozac - USA Today, 2/27/01
- Attention Deficit
Discovery - WebMD, 11/6/00 -
"When we gave these animals [Prozac], which affects
the serotonin system, it had a dramatic effect on learning and memory,
improving performance fourfold."
- Bulimia: Prozac
Can Help Where Talk Therapy Fails - WebMD, 8/3/00
-
FDA Approves Prozac To Treat Severe Premenstrual Syndrome -
Intelihealth, 7/7/00
- Questions Raised
About Prozac's Link to Violent Behaviors - WebMD, 6/22/00
-
A placebo-controlled study of fluoxetine versus imipramine in the acute
treatment of atypical depression - Medline, 3/00
- Older Tricyclics More
Effective Than Newer Antidepressants In Post-Stroke Depression -
Doctor's Guide, 3/2/00
- Effexor More Effective
Than Prozac In Achieving Remission In Depression - Doctor's Guide,
2/10/00
- FDA Advisory Panel
Recommends Prozac For Premenstrual Dysphoric Disorder - Doctor's Guide,
11/4/99
- FDA Approves Prozac For
Seniors With Depression - Doctor's Guide, 10/7/99
-
Study: Prozac no better than older depression drugs - CNN, 3/19/99
- Remeron Found Superior To
Fluoxetine In Early Depression Treatment - Doctor's Guide, 6/25/98
- Effexor XR Produces
Significantly Higher Depression Remission Rates Than Prozac - Doctor's
Guide, 6/2/98
Abstracts:
-
An open-label pilot study of the combination therapy of metformin and
fluoxetine for weight reduction - Int J Obes (Lond). 2006 Sep 12 -
"In a 6.68-month period, a 7.89 kg decrease in
weight (9.32%) and a 3.43 U decrease in BMI (10.14%) were observed in
participants of the case group that was statistically significant"
-
Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized,
controlled study in mild-moderate depression - Int Clin Psychopharmacol
2000 Mar;15(2):61-8 - "We concluded that
hypericum and fluoxetine are equipotent with respect to all main
parameters used to investigate antidepressants in this population. Although
hypericum may be superior in improving the responder rate, the main
difference between the two treatments is safety. Hypericum was superior to
fluoxetine in overall incidence of side-effects, number of patients with
side-effects and the type of side-effect reported"
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