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Anti-aging Research > RU-486
RU-486 (mifepristone)
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Scientists may have found one path to a longer life - Science Daily, 7/10/20
- "feeding mifepristone to the fruit flies that have
mated blocks the effects of sex peptide, reducing inflammation and keeping the
female flies healthier, leading to longer lifespans than their counterparts who
did not receive the drug"
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Drug
may help overwrite bad memories - Science Daily, 5/25/11
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RU-486 Abortion Drug Studied for Treatment of Pyschotic Depression - ABC
News, 8/23/10
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Merits and pitfalls of mifepristone in Cushing's syndrome - Eur J
Endocrinol. 2009 Mar 16
- Abortion drug may thwart
breast cancer - MSNBC, 11/30/06
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Two more women die after using the RU-486 - USA Today, 3/17/06
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Abortion Drug Adverse Events Reported - WebMD, 12/29/05
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First Analysis of FDA's Mifepristone Adverse Event Reports - Doctor's
Guide, 12/29/05
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First Analysis Of FDA's Mifepristone Adverse Event Reports - Science
Daily, 12/28/05
- Abortion pill maker alerts
doctors to 5 deaths - MSNBC, 7/18/05
- Mifepristone May Be
as Effective as Levonorgestrel for Emergency Contraception - Medscape,
12/15/04
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FDA: Abortion Pill Safe Enough For Sale - Intelihealth, 11/17/04
- Government
Issues New RU-486 Warnings - WebMD, 11/16/04
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FDA Announces Important Labeling Changes for Mifepristone - Doctor's
Guide, 11/16/04
- Mifeprex May Be
Associated With Risk of Serious Complications, Death - Medscape,
11/16/04
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More Safety Warnings For Abortion Pill - Intelihealth, 11/16/04
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Mifepristone May Ease Psychotic Depression - Clinical Psychiatry News,
6/04
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Low-Dose Mifepristone Shrinks Fibroids, Curbs Symptoms - Doctor's Guide,
4/2/03
- "Abortion Pill"
Shrinks Fibroids - WebMD, 2/4/03
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Mifepristone A Promising Estrogen-Free Contraceptive - Doctor's Guide,
1/28/03
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More Office-Based Physicians Offering Mifepristone - Clinical Psychiatry
News, 11/02
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Short Term Mifepristone Effective For Psychotic Major Depression -
Doctor's Guide, 10/22/02
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Mifepristone Shows Promise for Psychotic Depression - Clinical
Psychiatry News, 7/02
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Mifepristone Suppresses Ovulation and Menstruation - Doctor's Guide,
1/30/02
- RU-486 May Have
Birth Control Potential - WebMD, 2/4/02
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Researchers Explore New Meds for Mood Disorders - Clinical Psychiatry
News, 10/01 -
"Another approach being developed for patients with
high levels of circulating cortisol involves the abortion pill mifepristone
... The findings, to be published this month in the Journal of Clinical
Psychopharmacology, suggest that a rapid antidepressant response
(approximately 7 days) may occur in some patients"
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Researchers Hopeful Antidepressant Augmentation Will Improve Remission -
Clinical Psychiatry News, 9/01 -
"In psychotic depression, a corticosteroid
antagonist looks most promising. Mifepristone, which is used to induce
abortions but was originally designed as treatment for Cushing's disease,
has achieved rapid reversal of symptoms in some 30 psychotically depressed
patients, ostensibly by blocking cortisol receptors. The drug is now being
investigated in a large double-blind trial, he said"
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Abortion pill prescribed by relatively few doctors - USA Today, 10/1/01
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Abortion pill available to U.S. women as soon as Tuesday - CNN, 11/20/00
- RU-486 could aid variety of ills -
MSNBC, 11/2/00 -
"RU-486’s ability to block the action of a different
hormone — cortisol — has prompted doctors to try it for psychotic
depression. In addition to feeling sad and worthless, people with this
devastating condition have distorted thinking and often suffer delusions or
hallucinations. Many become suicidal.
“They have very, very disturbing and crazy thoughts ... and they have no
ability to suppress them,” said Joseph K. Belanoff, a California
psychiatrist who is chief executive officer of Corcept Therapeutics Inc., a
small pharmaceutical company. Corcept is sponsoring a study of RU-486 for
psychotic depression.
Several lines of evidence have led researchers to suspect that some of the
symptoms of psychotic depression are caused by an excess of cortisol in the
brain. Cortisol levels rise in response to stress and may be abnormally
elevated in depressed individuals. Similar symptoms can occur in patients
with Cushing’s syndrome, an overabundance of cortisol usually caused by a
tumor, and RU-486 has cured the mental disturbance in some
such cases.
“Our feeling has been that a lot of the cognitive problems and delusions that
you see in some of the patients are due to the [cortisol],” said Alan F.
Schatzberg, chairman of the psychiatry department at Stanford University
School of Medicine, where researchers are conducting a study that will test
RU-486 on 30 patients with psychotic depression.
RU-486 or other cortisol-blocking drugs “may be better alternatives than ...
some of the typical treatments” such as antipsychotic drugs or electric
shock therapy, he said."
- Findings Show Cortisol's
Major Role in AIDS and Other Diseases - Doctor's Guide, 6/21/96 -
"Researchers have already started to explore the
therapeutic benefits of such an approach through the use of anti-cortisol
drugs, such as RU-486, DHEA, Ketaconazole, Anticort and Tianeptine."
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