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Home >
Anti-aging Research >
Antidepressants & Psychotropics > Remeron®
(mirtazapine)
Remeron® (mirtazapine)
Related Topics:
Remeron & Cortisol:
-
Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma
concentrations in depressed patients - J Psychiatr Res. 2008 Aug 13 -
"Mirtazapine significantly reduced both COR and
DHEA-S concentrations, but had no impact on the COR/DHEA-S ratio"
-
Mirtazapine Attenuates Hypothalamic-pituitary-adrenocortical Axis
Hyperactivity in Depressed Patients - Doctor's Guide, 4/17/03 -
"it has been shown to have an acute inhibiting
effect on cortisol secretion in healthy
subjects ... Apparently, mirtazapine rapidly attenuates HPA axis
hyperactivity in depressed patients via
direct pharmaco-endocrinological effects. However, this amelioration of HPA
system dysregulation is not necessarily related to clinical improvement"
- Click here for a previous study.
- Mirtazapine Regulates
Stress Hormones, Improves Sleep In Depressed Patients - Doctor's Guide,
8/8/01
-
Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion
in healthy male subjects - Psychoneuroendocrinology 1999
Oct;24(7):769-84 - "The t-test for paired samples
revealed a highly significant difference (P < 0.01) in COR-AUC-values
between the mirtazapine group (mean COR-AUC: 1558.07 micrograms/100 ml x 240
min) and the placebo group (mean COR-AUC: 2698.86 micrograms/100 ml x 240
min)."
- Note: The way I read that, there was a 42% decrease in
cortisol with 15 mg of mirtazapine over a four hour period.
Click here for more info on the study.
News & Research:
-
Lipoic acid prevents
mirtazapine-induced weight gain in mice without impairs its antidepressant-like
action in a neuroendocrine model of depression - Behav Brain Res 2021 Nov 16
- "Mirtazapine (MIRT) is a multi-target antidepressant
used in treatment of severe depression with promising efficacy, but also with
important side effects, mainly sedation and weight gain ... Our findings provide
promising evidence about the ALA potential to prevent metabolic and weight
changes associated to MIRT, without impair its antidepressant and pro-cognition
actions. Therefore, ALA+MIRT combination could represent a new therapeutic
strategy for treating depression with less side effects" - See
alpha lipoic acid at Amazon.com.
-
How Does Mirtazapine
Induce Weight Gain? - Medscape, 3/6/09
-
Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other
New-Generation Antidepressants - Doctor's Guide, 1/29/09 -
"Sertraline and escitalopram were found to be the
best antidepressants overall in terms of efficacy and acceptability.
Sertraline was more efficacious than duloxetine (by 30%); than both
duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%);
paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more
efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by
35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and
escitalopram, mirtazapine and venlafaxine were also more efficacious than
these other drugs ... However, escitalopram and sertraline showed the best
profile of acceptability, leading to significantly fewer discontinuations of
treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and
venlafaxine"
-
Combining Mirtazapine (Remeron) with Other Antidepressants Improves
Remission Rates in Patients with Unipolar Depression - Doctor's Guide,
11/11/05
-
Antidepressant Combos Show Synergistic Benefit - Clinical Psychiatry
News, 9/05 - "combined mirtazapine and paroxetine
(Paxil) achieved superior remission of depression, compared with either
agent alone ... mirtazapine increases norepinephrine, and long-term
treatment with selective serotonin reuptake inhibitors such as paroxetine
can decrease levels of this neurotransmitter"
-
Mirtazapine Betters Major SSRIs for Treatment of Depression - Doctor's
Guide, 5/27/05 - "A meta-analysis of clinical trials
involving more than 2,500 subjects suggests that treatment of depression
with mirtazapine (Remeron) results in a more rapid onset of clinical
improvement compared to treatment with fluoxetine, paroxetine, and
sertraline (all SSRIs)" - See Remeron (mirtazapine) at
OffshoreRx1.com.
-
Mirtazapine Tied to Psychomotor Deficits - Clinical Psychiatry News,
12/04
-
Mirtazapine Plus Clozapine Appears to Improve Negative Symptoms of
Schizophrenia - Doctor's Guide, 4/21/04
-
Patient with Delayed, Persistent Initial Response To Mirtazapine May Benefit
the Most from Continued Therapy - Doctor's Guide, 4/5/04
-
Mirtazapine More Effective Than Sertraline On Veterans' Post-Traumatic
Stress Disorder - Doctor's Guide, 10/14/03
-
Mirtazapine Effective For Anxiety and Depression in Alcohol Detoxification
- Doctor's Guide, 10/6/03
-
Mirtazapine Can Be Added To Clozapine, Risperidone Or Olanzapine Without
Pharmacokinetic Interaction, In Treatment Of Schizophrenia - Doctor's
Guide, 8/21/03
-
Case Report: Mirtazapine Associated With Hypertriglyceridaemia, Acute
Pancreatitis And Diabetic Ketoacidosis - Doctor's Guide, 8/13/03
-
Try Mirtazapine or Escitalopram for Speedy Onset - Clinical Psychiatry
News, 8/03 -
"When you need the quickest possible
antidepressant effect, consider choosing mirtazapine or
escitalopram for treatment or combining a selective serotonin reuptake
inhibitor with
pindolol
or olanzapine"
-
Mirtazapine Reduces Sleep Interruptions - Physician's Weekly, 7/7/03
- Antidepressant
[Remeron] Is Promising for Sleep Apnea - WebMD, 6/5/03
-
Mirtazapine Lifts Mood of Older Depressed Patients - Clinical Psychiatry
News, 6/03 -
"The drug's anxiolytic and sleep-improving
properties, minimal gastrointestinal side effects, low risk of drug-drug
interactions, and modest associated weight gain are significant advantages"
-
Venlafaxine Beats Selective Serotonin-Reuptake Inhibitors in Remission of
Depression - Doctor's Guide, 5/22/03 -
"The results of this largest-of-all comparative
study of venlafaxine and
other agents supports the conclusions of other investigators that,
compared to other SSRIs, venlafaxine helps patients achieve remission of
symptoms at relatively higher rates" - Note: Venlafaxine increases
both serotonin and
norepinephrine, as does mirtazapine and the investigational drug
duloxetine.
-
Mirtazapine-Amitriptyline Combination Warrants Caution - Doctor's Guide,
3/12/03
-
Oral Mirtazapine Effective, Well-tolerated by Depressed Nursing-Home
Patients - Doctor's Guide, 3/7/03
-
Mirtazapine May Be Superior to Sertraline in Onset Time, Symptom Reduction
among Patients with Major Depression - Doctor's Guide, 11/4/02
-
Intravenous Mirtazapine Effective In Treating Depression - Doctor's
Guide, 2/1/02
- Doctors Target
Two Brain Chemicals to Treat Depression, Anxiety - WebMD, 9/17/01 -
"Prozac works by increasing the availability of the
mood chemical serotonin, while Effexor targets serotonin and norepinephrine,
another brain chemical that plays a role in anxiety and depression ...
there's a whole series of other studies in the area of anxiety disorders and
new medications that are in development that target both brain chemicals ...
One such drug, Remeron, is currently available"
- New Options for
Severe Depression - WebMD, 7/23/01
- Remeron SolTab
(Mirtazapine) Effective, Safe for Treatment of Depression in Senior Citizens
- Doctor's Guide, 5/8/01 -
"But what we found here is that mirtazapine was
faster-acting and produced an overall better result in the first six weeks
of treatment than paroxetine"
- Mirtazapine May Improve
Parkinsonian Tremor And Essential Tremor - Doctor's Guide, 5/8/01
- FDA Approves Remeron
SolTab (Mirtazapine) For Depression - Doctor's Guide, 1/12/01
-
Mirtazapine Effective And Well-Tolerated Anti-Depressant - Doctor's
Guide, 1/8/01
- New
Antidepressant Also Helps You Sleep - WebMD, 7/25/00
- Mirtazapine as a Treatment
for Major Depression - Doctor's Guide, 5/18/00 -
"Results show that mirtazapine seemed to have a
faster onset of action than did citalopram"
- Paroxetine Safer than
Mirtazapine for Car Driving Performance - Doctor's Guide, 5/18/00
- Remeron Relieves
Depression Quicker Than Do Some SSRIs - Doctor's Guide, 12/15/99
- Depression Drug,
Mirtazapine, Steadies Hand Tremor - Doctor's Guide, 9/22/99
- Remeron More Effective,
Faster Working Than Cipramil or Paxil, Study Shows - Doctor's Guide,
11/3/98
- Remeron Found Superior To
Fluoxetine In Early Depression Treatment - Doctor's Guide, 6/25/98
- Remeron Cleared by FDA for
the Treatment of Depression - Doctor's Guide, 6/19/96
Abstracts:
-
Effect of mirtazapine treatment on body composition and metabolism - J
Clin Psychiatry. 2006 Mar;67(3):421-4 - "The
antidepressant therapy with mirtazapine was associated with a significant
increase in body weight, body fat mass, and leptin concentration"
-
Which antidepressants have demonstrated superior efficacy? A review of the
evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 -
"Criteria were defined to judge the strength of
evidence. Two pivotal studies in moderate-to-severe major depressive
disorder that demonstrate superiority on the primary efficacy measure, or
alternatively one pivotal study supported by consistent results from
meta-analyses, was considered to constitute evidence for definite
superiority. Three antidepressants met these criteria: clomipramine,
venlafaxine, and escitalopram. Three antidepressants were found to have
probable superiority: milnacipran, duloxetine, and mirtazapine. Only
escitalopram was found to have definite superiority in the treatment of
severe depression; probable superiority was identified for venlafaxine and
possible superiority for milnacipran and clomipra"
-
Effect of mirtazapine treatment on body composition and metabolism - J
Clin Psychiatry. 2006 Mar;67(3):421-4 - "The
antidepressant therapy with mirtazapine was associated with a significant
increase in body weight, body fat mass, and leptin concentration"
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