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Health Conditions > Schizophrenia >
Antidepressants & Psychotropics > Zyprexa®
(olanzapine)
Zyprexa® (olanzapine) (Eli Lilly and Co.)
Related Topics:
CME:
News & Research:
-
olanzapine at drugstore.com
-
Zyprexa (olanzapine) - rxlist.com
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Newer Antipsychotic Drugs Increase the Risk of Sudden Cardiac Death
- WebMD, 1/14/09 - "because these older
agents cause movement disorders in some patients, they have largely
been replaced with newer medications such as Zyprexa, Risperdal, and
Seroquel ... Although the study's results reaffirmed that people who
use the older antipsychotic drugs are twice as likely as nonusers to
have sudden cardiac death, it also showed a similar increase in risk
for the newer medications. For these, the rate of sudden cardiac
death was more than twice that for nonusers"
-
Treatment With An Anti-psychotic Drug Found To Cause Changes In
Metabolism Earlier Than Expected - Science Daily, 4/7/08
-
Comparison Of Antipsychotic Treatments In Adolescents With
Schizophrenia - Science Daily, 2/28/08 -
"The researchers discovered that clozapine was approximately twice
as likely to produce a treatment response as olanzapine"
-
Olanzapine May Be New Option for Post-Traumatic Stress Disorder
- Doctor's Guide, 10/19/07
-
Lilly Adds Label Warnings for Mental Illness Drug - New York
Times, 10/5/07
-
First Head-to-Head Study Suggests Significantly Greater Symptom
Improvement for Olanzapine and Fluoxetine Combination Capsules
Compared to Lamotrigine in Bipolar Depression - Doctor's Guide,
5/30/06
-
Study Suggests Olanzapine and Fluoxetine Combination Capsules
Improve Symptoms of Treatment-Resistant Depression - Doctor's
Guide, 5/30/06
-
Lithium, Olanzapine Affect Different Domains in Bipolar -
Clinical Psychiatry News, 11/05
- CAFE Study
Shows Varying Benefits Among Atypical Antipsychotics - Medscape,
10/25/05
-
Atypical Antipsychotics Offer Equivalent Benefit in First-Episode
Psychosis
- Doctor's Guide, 10/25/05
-
Antipsychotic Drugs: OK for Dementia Patients? - WebMD, 10/18/05
-
Olanzapine vs. Risperidone in Schizophrenia - Clinical
Psychiatry News, 9/05
-
Aripiprazole Wins Out in Comparison With Olanzapine - Clinical
Psychiatry News, 9/05
-
Schizophrenia Drug Face-Off: No Clear Winner - WebMD, 9/19/05
-
Leading schizophrenia drug no better than older, cheaper kind -
USATODAY.com, 9/19/05
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Long-Term Study Shows Geodon (Ziprasidone HCl) Has Comparable
Efficacy With Fewer Adverse Metabolic Effects Than Zyprexa
(Olanzapine) - Doctor's Guide, 8/8/05
- Olanzapine
May Be Better Than Lithium in Bipolar Disorder - Medscape,
7/8/05
-
Second-Generation Antipsychotics Equally Effective in Schizophrenia
- Medscape, 6/30/05
-
New Antipsychotic Drug Prevents Brain Loss In Schizophrenia -
Doctor's Guide, 4/5/05
-
Olanzapine, Risperidone Outshine Others in Study - Clinical
Psychiatry News, 1/05
-
Novel Antipsychotics Found Effective in Bipolar Disorder -
Clinical Psychiatry News, 1/05
-
Two Atypical Anti-psychotic Drugs May Be Associated With An
Increased Risk Of Diabetes For Patients With Schizophrenia -
Science Daily, 1/5/05
-
Clozapine, Olanzapine May be Associated with Increased Risk of
Diabetes for Patients with Schizophrenia - Doctor's Guide,
1/3/05
-
Long-Term Treatment With Zyprexa (Olanzapine) Appears to Reduce
Violent Behavior in People With Schizophrenia Compared To
Risperidone - Doctor's Guide, 12/14/04
-
Comparative Study Shows Differences Between Atypical Antipsychotic
Medications Geodon (Ziprasidone) and Zyprexa (Olanzapine) -
Doctor's Guide, 10/12/04
-
Some Anti-Psychotic Medications May Trigger Diabetes - Science
Daily, 10/8/04 -
"The rate is five to 10 times higher than
the estimated rate of 6.3 cases per 1,000 in the general U.S.
population"
-
Seizure Drug Combats Antipsychotic Side Effects - Psychiatric
News, 6/18/04
-
Olanzapine Appears More Effective Than Risperidone For Long-Term
Negative Social Functioning Symptoms in Schizophrenia Patients -
Doctor's Guide, 5/6/04
-
Olanzapine Cuts Risk of Tardive Dyskinesia in Elderly Patients On
Antipsychotics - Doctor's Guide, 4/30/04
-
Olanzapine Gets Warning For Use in Elderly - Psychiatric News,
4/16/04
-
Higher Mortality Seen in Olanzapine-Treated Elderly - Clinical
Psychiatry News, 4/04
-
FDA Approves Injectable Form of Zyprexa (Olanzapine) - Doctor's
Guide, 3/29/04
- Olanzapine
Labeling Change Indicates Risk of Hyperglycemia, Diabetes -
Medscape, 3/22/04
-
Olanzapine May Work as Adjunctive Therapy for Non-Responsive GAD
Patients - Doctor's Guide, 3/16/04
-
Glycine Reduces Negative And Cognitive Symptoms in Schizophrenic
Patients Taking Olanzapine Or Risperidone - Doctor's Guide,
3/16/04 - See
Vitacost
glycine products.
-
Electroencelphalogram Abnormalities Appear Less Frequent With
Quetiapine Than With Haloperidol and Olanzapine - Doctor's
Guide, 3/10/04
- Lilly
Warns of Zyprexa Risks Among Elderly - WebMD, 2/20/04
-
Zyprexa Appears to Delay Relapse in Patients with Schizophrenia
Significantly Longer Than Other Atypical Antipsychotics -
Doctor's Guide, 2/11/04
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Olanzapine Comparable to Haloperidol, Causes Fewer Extrapyramidal
Symptoms - Doctor's Guide, 2/6/04
-
Olanzapine Therapy May Cause Rapid Induction of Insulin Resistance
- Doctor's Guide, 2/3/04
- New
Drug for Long-Term Bipolar Treatment - WebMD, 1/15/04
-
FDA Approves Zyprexa (Olanzapine) for Maintenance of Bipolar
Disorder - Doctor's Guide, 1/15/04
-
Olanzapine Helps Compliance in Schizophrenia - Clinical
Psychiatry News Online, 1/04
-
FDA Approves Symbyax (Olanzapine and Fluoxetine), First Medication
for Bipolar Depression - Doctor's Guide, 12/30/03
-
No Difference In Remission Of Manic Episodes In Bipolar Patients
Taking Olanzapine Or Haloperidol - Doctor's Guide, 12/11/03
-
Olanzapine Has Similar Efficacy, Costs More Than Haloperidol for
Treatment of Schizophrenia - Doctor's Guide, 12/9/03
-
Olanzapine Has Similar Efficacy, Costs More Than Haloperidol for
Treatment of Schizophrenia - Doctor's Guide, 11/27/03
-
Olanzapine Helps to Delay Bipolar Recurrence - Clinical
Psychiatry News Online, 11/03
-
Haloperidol, not Olanzapine, Linked With Brain Shrinkage in
Schizophrenia - Doctor's Guide, 11/11/03
-
Nutrition Counseling Effective in Controlling Weight Gain Associated
With Olanzapine Use - Doctor's Guide, 11/3/03
- Olanzapine
Reduces Violence Risk - Medscape, 10/31/03
-
FDA to Require Diabetes Warning On Antipsychotics - Psychiatric
News, 10/17/03
-
Weight Gain is Potential Problem in Patients Switched from
Risperidone to Olanzapine - Doctor's Guide, 10/16/03
-
Olanzapine/Fluoxetine Combination Treats Bipolar Depression Without
Triggering Mania - Doctor's Guide, 10/14/03
-
Switch From Oral Olanzapine to Depot Risperidone Safe, May Improve
Symptoms - Doctor's Guide, 10/3/03
-
Olanzapine Treatment Associated with a Higher Incidence of Diabetes
in Patients with Psychoses - Doctor's Guide, 9/17/03
-
Antipsychotic-Induced Metabolic Syndrome Proves Costly -
Clinical Psychiatry News, 9/03
-
Oral Olanzapine May Effectively Treat Agitation in Schizophrenia Or
Bipolar Disorder - Doctor's Guide, 8/29/03
-
Olanzapine More Effective Against Manic Relapse - Clinical
Psychiatry News, 8/03
-
Try Mirtazapine or Escitalopram for Speedy Onset - Clinical
Psychiatry News, 8/03 -
"When you need the quickest possible
antidepressant effect, consider choosing
mirtazapine or
escitalopram for treatment or
combining a selective serotonin reuptake inhibitor with
pindolol or olanzapine"
- Olanzapine
Relatively Safe During Breast-Feeding - Medscape, 8/8/03
-
FDA Approves Zyprexa for Use in Combination with Lithium or
Valproate to Treat Acute Manic Episodes of Bipolar I Disorder -
Doctor's Guide, 7/16/03
-
Therapeutic Dose Equivalency Calculation Method Proposed for
Atypical Antipsychotic Medications - Doctor's Guide, 7/16/03 -
"The reported minimum effective doses
identified were 4 mg/day for risperidone, 10 mg/day for olanzapine,
150 mg/day for quetiapine, 120 mg/day for ziprasidone, 15 mg/day for
aripiprazole, and 4 mg/day for haloperidol"
- Olanzapine
May Be Better Than Divalproex in Acute Mania - Medscape, 7/10/03
-
Orally Disintegrating Zyprexa Zydis Reduces Acute or Breakthrough
Symptoms of Schizophrenia - Doctor's Guide, 6/24/03
-
Supratherapeutic Dosing of Olanzapine May Help Refractory
Schizophrenia - Clinical Psychiatry News, 5/03
-
Novel Antipsychotic's Side Effect Profile Offers Benefits -
Clinical Psychiatry News, 5/03
-
Antipsychotics Effective for Elderly Patients With Dementia -
Psychiatric News, 4/18/03 -
"atypical
antipsychotics have been used to alleviate deteriorating
behavioral symptoms in dementia patients, such as agitation and
aggression. New research that she cited shows some atypical
antipsychotics can actually improve cognition through activating the
release of acetylcholine in the cortex.
Clozapine,
olanzapine, and
risperidone, she reported,
robustly increased acetylcholine release in the cortex, while
ziprasidone
only moderately increased levels, compared with
haloperidol and thioridazine, which did not elevate
acetylcholine levels at all ... atypical antipsychotics increase
cortical dopamine and cholinesterase
inhibitors at the very least increase cortical acetylcholine
action, leading to an improvement in memory and thinking, as well as
improvement in psychosis and behavior"
- 2
Schizophrenia Drugs Square Off - WebMD, 4/7/03
-
Atypical Antipsychotics - Clinical Psychiatry News, 4/03
-
Careful Monitoring of Children on Atypicals Is Critical -
Clinical Psychiatry News, 4/03 -
"Olanzapine and
risperidone use in children and
adolescents is associated with significantly more weight gain than
quetiapine"
-
Olanzapine Broadly Effective In Acute Dysphoric Mania - Doctor's
Guide, 3/31/03
-
Antipsychotic Linked Weight Gain Not Counteracted By Serotonin
Reuptake Inhibitors - Doctor's Guide, 3/24/03
-
Health Canada Approves Zyprexa (Olanzapine), Treatment For Bipolar
Disorder - Doctor's Guide, 3/18/03
-
Antipsychotics and Glucose Dysregulation: Their Relationship to
Treatment Decisions - Psychiatric Times, 3/03
-
Olanzapine Improves Behaviour Disturbances in Nursing-Home Patients
with Alzheimer's Disease - Doctor's Guide, 3/4/03
-
Antipsychotics Raise Glucose, Cholesterol Levels In Schizophrenics
- Doctor's Guide, 2/25/03 -
"Clozapine, olanzapine and haloperidol are
associated with increased plasma glucose level, and clozapine and
olanzapine with raised cholesterol"
-
Olanzapine Improves Psychotic Symptoms In Adolescents With
Schizophrenia - Doctor's Guide, 1/31/03
-
Olanzapine/Fluoxetine Combination Effective In Psychotic Depression
- Doctor's Guide, 1/20/03
-
Studies Support Calming Effect of Olanzapine - Clinical
Psychiatry News, 1/03
-
Some Antipsychotics May Be Tied To Increased Type 2 Diabetes Risk
- Clinical Psychiatry News, 1/03 -
"the risk was increased by 3.1 among those
on olanzapine (Zyprexa), 7.44 times among those on clozapine, 2.13
among those on high-potency conventional antipsychotics such as
haloperidol and fluphenazine, and by 3.46 times among those on
low-potency conventional antipsychotics such as chlorpromazine and
thioridazine"
-
Fewer Side Effects With Mood Stabilizer Depakote (Divalproex Sodium)
Than With Antipsychotic Zyprexa (Olanzapine) - Doctor's Guide,
12/16/02
-
Olanzapine For Schizophrenia Quintuples Hyperlipidaemia Risk -
Doctor's Guide, 12/4/02
-
Olanzapine Goes Head-to-Head With Flupenthixol - Clinical
Psychiatry News, 12/02
-
Try Higher Doses of Atypicals Before Giving Up - Clinical
Psychiatry News, 12/02
-
Olanzapine May Produce Rapid, Sustained Reduction in Prolactinemia
in Patients with Schizophrenia - Doctor's Guide, 11/5/02
-
Olanzapine May be Superior to Divalproex in Achieving Remission from
Mania - Doctor's Guide, 11/4/02
-
Zyprexa (Olanzapine) Reduces Recurrence in Combination Therapy for
Bipolar Disorder - Doctor's Guide, 11/1/02
-
Zyprexa (Olanzapine) Has Potential in Treating Adolescent Psychosis
- Doctor's Guide, 10/28/02
-
Olanzapine Safe and Effective for Adolescent Bipolar Disorder -
Doctor's Guide, 10/25/02
-
Olanzapine Benefits Older Patients - Clinical Psychiatry News,
10/02
-
Studies Cite Links Between Olanzapine, Diabetes - Clinical
Psychiatry News, 10/02
-
Olanzapine Does Not Reduce Hallucinations In Parkinson's Disease
- Doctor's Guide, 10/17/02
-
Olanzapine Decreases Neuroleptic-induced Hyperprolactinemia in
Schizophrenic Patients - Doctor's Guide, 10/16/02
-
Olanzapine Shows Promise In Management of Tardive Dyskinesia In
Schizophrenics - Doctor's Guide, 10/15/02
-
Olanzapine Decreases Neuroleptic-Induced Hyperprolactinemia in
Schizophrenic Patients - Doctor's Guide, 10/14/02
-
Olanzapine Reduces Tardive Dyskinesia Symptoms - Doctor's Guide,
10/9/02
-
Olanzapine/Fluoxetine Combination for Treatment-Resistant and
Psychotic Depression Raises No New Safety Issues - Doctor's
Guide, 10/9/02
-
Schizophrenia Drugs [Zyprexa and Seroquel] Treat Bipolar -
WebMD, 9/18/02
-
New Data Suggest Zyprexa (Olanzapine) Superior To Standard Of Care
(Lithium) For Preventing Mania Relapse In Bipolar Disorder -
Doctor's Guide, 9/16/02
-
Reduction of Psychotic Symptoms by Olanzapine in Patients with
Probable Lewy Body Dementia - Doctor's Guide, 9/2/02
-
Olanzapine-Fluoxetine for Treatment-Resistant Depression -
Doctor's Guide, 9/2/02
-
Olanzapine Versus Risperidone: A Comparison Of Hospital Length Of
Stay In Adult Inpatients With Schizophrenia - Doctor's Guide,
9/2/02
-
Olanzapine Effective For Chronic Headache But Should Be Used With
Caution - Doctor's Guide, 8/30/02
-
Olanzapine-Fluoxetine Better Than Olanzapine Alone For Psychotic
Depression - Doctor's Guide, 8/29/02
-
Olanzapine Appears More Effective Than Divalproex In Treatment Of
Bipolar Mania - Doctor's Guide, 8/29/02
-
Schizophrenics Taking Olanzapine Have Increased Diabetes Risk -
Doctor's Guide, 8/5/02
-
Rapid-Acting Olanzapine Effective in Acutely Agitated Patients with
Dementia - Doctor's Guide, 7/22/02
- Warning About
Antipsychotic Drug [Zyprexa] - Doctor's Guide, 7/1/02
-
Olanzapine for Developmental Stuttering - Clinical Psychiatry
News, 7/02
- Olanzapine
Linked to Increased Risk of Diabetes - Doctor's Guide, 6/27/02
- Amisulpride
Found Efficacious in Schizophrenia with Less Weight Gain than
Olanzapine - Doctor's Guide, 6/26/02
- Olanzapine and
Fluoxetine Improve Quality of Life in Bipolar Patients -
Doctor's Guide, 6/25/02
- Olanzapine
Reduces Need for Anticholinergics in Elderly Schizophrenics -
Doctor's Guide, 6/24/02
-
News - Possible Genetic Linkage Cited in Antipsychotic Drug Weight
Gain - Doctor's Guide, 6/13/02
-
Olanzapine Effective Treatment For Mania In Non-Responders To
Earlier Mood Stabilisers - Doctor's Guide, 5/30/02
- Olanzapine
Effective for the Treatment of Bipolar Depression - Doctor's
Guide, 5/27/02
-
Olanzapine May Improve Social Cognition in Patients with
Schizophrenia - Doctor's Guide, 5/23/02
-
Lamotrigine, Olanzapine Stabilize Mood in Bipolar Disorder -
Medscape, 5/23/02
-
Olanzapine-Fluoxetine Combination Shows Promise for Psychotic Major
Depression - Doctor's Guide, 5/22/02
-
Olanzapine Plus Lithium or Valproate Effective for Bipolar Relapse
Prevention - Doctor's Guide, 5/22/02
-
Olanzapine Proves Useful in Managing Psychocutaneous Disorders -
Clinical Psychiatry News, 5/02
-
Optimal Management of Psychosis & Agitation in the Elderly -
Medscape, 3/20/02
-
Olanzapine Curbs Tardive Dyskinesia - Clinical Psychiatry News,
3/02
-
Divalproex Enhances Efficacy of Antipsychotics - Clinical
Psychiatry News, 3/02
-
Risperidone and Olanzapine May Reduce Risk of Extrapyramidal
Symptoms - Doctor's Guide, 1/17/02
- Newer
Antipsychotics Linked to Weight Gain - Doctor's Guide, 11/19/01
- Olanzapine May
Reduce Symptoms Associated With Antipsychotic Therapies -
Doctor's Guide, 11/19/01
- High Doses of
Olanzapine do not Increase Prolactin Levels - Doctor's Guide,
11/18/01
- Zyprexa
(Olanzapine) IntraMuscular Rapidly Controls Acute Agitation in
Bipolar Mania - Doctor's Guide, 8/2/01
- Ziprasidone Has
Less Effect Than Olanzapine on Weight, Lipids, Insulin Levels in
Schizophrenia - Doctor's Guide, 7/23/01
- Olanzapine
Reduces Alzheimer Agitation And Psychosis - Doctor's Guide,
6/18/01
- Olanzapine Has
No Anticholinergic Effects in Elderly Patients With Dementia -
Doctor's Guide, 5/11/01
- Geodon
(Ziprasidone HCl) Better Tolerated Than Zyprexa (Olanzapine) In
Schizophrenia and Schizoaffective Disorders - Doctor's Guide,
5/8/01
- Axid
(Nizatidine) Cuts Weight Gain During Zyprexa (Olanzapine) Treatment
For Schizophrenia - Doctor's Guide, 5/3/01
- Seroquel
(Quetiapine): First-choice Treatment for Young People With Psychotic
Illness - Doctor's Guide, 5/1/01
-
Olanzapine's And Clozapine's Effect On Weight Gain Related To
Insulin And Leptin - Doctor's Guide, 3/26/01 -
"the median insulin level was significantly
higher in olanzapine patients ... In the clozapine group, insulin
levels were positively correlated to the drug serum concentration"
- Intramuscular
Zyprexa (Olanzapine) Controls Agitation In Elderly With Dementia
- Doctor's Guide, 2/27/01
- Fewer Side
Effects With Depakote (Divalproex) Than With Olanzapine For Acute
Mania - Doctor's Guide, 12/12/00 -
"The following adverse events showed a
statistically significant difference: edema (0 percent vs. 14
percent), somnolence (29 percent vs. 47 percent), speech disorder (0
percent vs. 7 percent), rhinitis (3 percent vs. 14 percent) and
weight gain (10 percent vs. 25 percent), in the Depakote- and
olanzapine-treated groups respectively ... Depakote patients had
significantly less weight gain than olanzapine patients ... Cases of
life-threatening pancreatitis, some rapidly progressing to death,
have been reported in both adults and children receiving valproate.
The frequency of adverse effects, particularly elevated liver
enzymes and thrombocytopenia may be dose-related. Valproate may
produce teratogenic effects in the offspring of women receiving the
drug during pregnancy. Depakote (divalproex sodium) is a derivative
of valproic acid"
-
Fatal Reaction Linked To Olanzapine Use - Doctor's Guide,
11/16/00
- FDA Approves
Zyprexa (Olanzapine) For Long-Term Treatment Of Schizophrenia -
Doctor's Guide, 11/13/00
- Orally
Disintegrating Formulation Of Antipsychotic Zyprexa (Olanzapine) Now
Available - Doctor's Guide, 9/18/00
- Zyprexa
(Olanzapine) Superior To Depakote (Valproate) For Acute Mania In
Bipolar Disorder - Doctor's Guide, 9/11/00
- Intramuscular
Zyprexa (Olanzapine) More Rapid, Effective Than Haloperidol -
Doctor's Guide, 7/12/00
- Maximizing
Functional Outcome in Psychotic Patients - Doctor's Guide,
5/23/00
- Olanzapine
Effective for Juvenile Bipolar Disorder - Doctor's Guide,
5/18/00
- Olanzapine
Reduces Behavioral and Psychotic Symptoms in Alzheimer's Patients
- Doctor's Guide, 5/16/00
- Zyprexa
(Olanzapine) Has Superior Benefits to Risperdal (Risperidone) in
Treating Schizophrenia
- Doctor's Guide, 5/12/00
- Olanzapine
Appears To Aggravate Parkinsonism - Doctor's Guide, 5/8/00
- Olanzapine may
reduce psychotic symtoms in patients with dementia - Doctor's
Guide, 5/3/00
- Risperdal
(Risperidone) For Schizophrenia More Cost-effective Than Olanzapine
- Doctor's Guide, 4/27/00
- FDA Approves
Zyprexa (Olanzapine) For Manic Episodes In Bipolar Disorder -
Doctor's Guide, 3/20/00
- Zyprexa Receives
Approvable Letter For Treatment Of Acute Mania In Bipolar Disorder
- Doctor's Guide, 10/28/99
- Risperidone More
Cost Effective Than Olanzapine - Doctor's Guide, 9/24/99
- Olanzapine
Highly Effective In Bipolar Disorder - Doctor's Guide, 9/22/99
- Zyprexa Reduces
Hyperprolactinemia Prevalence In Schizophrenia Patients -
Doctor's Guide, 8/2/99
- Zyprexa Reduces
Symptoms Of Mania, Severe Depression In Bipolar Disorder -
Doctor's Guide, 6/18/99
- Cognitive
Improvement Associated With Olanzapine - Doctor's Guide, 5/28/99
-
"olanzapine produces more significant
reduction in cognitive dysfunction in patients with early stage
schizophrenia over a one-year treatment period than do risperidone
and haloperidol"
- Combination
Treatment Often Necessary For Bipolar Disorder - Doctor's Guide,
5/27/99
- Zyprexa Reduces
Behavioural, Psychiatric Symptoms Related To Alzheimer's -
Doctor's Guide, 12/15/98
- Olanzapine More
Tolerable, As Effective As Clozaril For Treatment-Resistant Patients
- Doctor's Guide, 10/30/98
- Zyprexa Reduces
Symptoms In Alzheimer’s Patients - Doctor's Guide, 9/22/98
- Antipsychotic
Olanzapine Doesn’t Increase Prolactin Levels - Doctor's Guide,
6/3/98
- Atypical
Antipsychotics May Be Used In First-Line Treatment Of Brain
Disorders - Doctor's Guide, 12/1/97
- Study Shows New
Schizophrenia Drug is Safer, More Effective - Doctor's Guide,
4/23/97
- Zyprexa Cleared by
the FDA for Treatment of Psychotic Disorders - Doctor's Guide,
10/1/96
Abstracts:
-
Metformin as an adjunctive treatment to control body weight and
metabolic dysfunction during olanzapine administration: A
multicentric, double-blind, placebo-controlled trial - Schizophr
Res. 2007 Jul;93(1-3):99-108 -
"Metformin may safely assist
olanzapine-treated patients in body weight and carbohydrate
metabolism control"
-
Life-threatening hyperglycemia and acidosis related to olanzapine: a
case report and review of the literature - J Intensive Care Med.
2007 Jan-Feb;22(1):52-5 - "The authors
postulate that treatment with olanzapine precipitated hyperglycemia,
an elevated creatine kinase level, and a high amylase level"
-
Risk of diabetes mellitus associated with atypical antipsychotic use
among medicaid patients with bipolar disorder: a nested case-control
study - Pharmacotherapy. 2007 Jan;27(1):27-35 -
"the risk of diabetes was greatest among patients
taking risperidone (hazard ratio [HR] 3.8, 95% confidence interval
[CI] 2.7-5.3), olanzapine (3.7, 95% CI 2.5-5.3), and quetiapine
(2.5, 95% CI 1.4-4.3). The risk for developing diabetes was also
associated with weight gain (HR 2.5, 95% CI 1.9-3.4), hypertension
(HR 1.6, 95% CI 1.2-2.2), and substance abuse (HR 1.5"
-
Effect of Olanzapine on Body Composition and Energy Expenditure in
Adults With First-Episode Psychosis - Am J Psychiatry
162:118-123, January 2005 -
"After approximately 12 weeks of olanzapine
therapy, the median increase in body weight was 4.7 kg, a
significant increase of 7.3% from first observation ... Olanzapine
appears to have induced an increase in central body fat deposition,
insulin, and triglyceride levels, suggesting the possible
development of insulin resistance. The decrease in fat oxidation may
be secondary or predispose patients to olanzapine-induced weight
gain"
-
Attenuation of Olanzapine-Induced Weight Gain With Reboxetine in
Patients With Schizophrenia: A Double-Blind, Placebo-Controlled
Study
- Am J Psychiatry 160:297-302, 2/03
-
An Assessment of the Independent Effects of Olanzapine and
Risperidone Exposure on the Risk of Hyperlipidemia in Schizophrenic
Patients - Archives of General Psychiatry, 11/02 -
"Olanzapine use was associated with nearly a
5-fold increase in the odds of developing hyperlipidemia compared
with no antipsychotic exposure"
-
A Double-blind, Placebo-Controlled Dose-Response Comparison of
Intramuscular Olanzapine and Haloperidol in the Treatment of Acute
Agitation in Schizophrenia - Archives of General Psychiatry,
5/02
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